Chr	ORF	Gene	Observations	Best log(e)	EC	Description
A	YAL001C	TFC3	358	-384.2	4	Largest of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauB domain of TFIIIC that binds DNA at the BoxB promoter sites of tRNA and similar genes; cooperates with Tfc6p in DNA binding [Source:SGD;Acc:S000000001]
A	YAL002W	VPS8	188	-199	4	Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif [Source:SGD;Acc:S000000002]
A	YAL003W	EFB1	3974	-702.3	4	Translation elongation factor 1 beta; stimulates nucleotide exchange to regenerate EF-1 alpha-GTP for the next elongation cycle; part of the EF-1 complex, which facilitates binding of aminoacyl-tRNA to the ribosomal A site [Source:SGD;Acc:S000000003]
A	YAL004W	YAL004W	6	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C [Source:SGD;Acc:S000002136]
A	YAL005C	SSA1	8381	-4346.6	4	ATPase involved in protein folding and nuclear localization signal (NLS)-directed nuclear transport; member of heat shock protein 70 (HSP70) family; forms a chaperone complex with Ydj1p; localized to the nucleus, cytoplasm, and cell wall; 98% identi  th Ssa2p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes [Source:SGD;Acc:S000000004]
A	YAL007C	ERP2	1030	-216.4	4	Protein that forms a heterotrimeric complex with Erp1p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles [Source:SGD;Acc:S000000005]
A	YAL008W	FUN14	188	-45.7	4	Mitochondrial protein of unknown function [Source:SGD;Acc:S000000006]
A	YAL009W	SPO7	43	-45.2	4	Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation [Source:SGD;Acc:S000000007]
A	YAL010C	MDM10	175	-277	4	Subunit of both the ERMES complex that links the ER to mitochondria, and of the mitochondrial sorting and assembly machinery (SAM complex) that functions in import and assembly of outer membrane beta-barrel proteins [Source:SGD;Acc:S000000008]
A	YAL011W	SWC3	189	-2304	4	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for formation of nuclear-associated array of smooth endoplasmic reticulum known as karmellae [Source:SGD;Acc:S000000009]
A	YAL012W	CYS3	3332	-787	4	Cystathionine gamma-lyase, catalyzes one of the two reactions involved in the transsulfuration pathway that yields cysteine from homocysteine with the intermediary formation of cystathionine [Source:SGD;Acc:S000000010]
A	YAL013W	DEP1	362	-204.3	4	Transcriptional modulator involved in regulation of structural phospholipid biosynthesis genes and metabolically unrelated genes, as well as maintenance of telomeres, mating efficiency, and sporulation [Source:SGD;Acc:S000000011]
A	YAL014C	SYN8	210	-164.9	4	Endosomal SNARE related to mammalian syntaxin 8 [Source:SGD;Acc:S000000012]
A	YAL015C	NTG1	112	-102.9	4	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress [Source:SGD;Acc:S000000013]
A	YAL016C-A	YAL016C-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028728]
A	YAL016C-B	YAL016C-B	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028528]
A	YAL016W	TPD3	1686	-646.9	4	Regulatory subunit A of the heterotrimeric protein phosphatase 2A (PP2A), which also contains regulatory subunit Cdc55p and either catalytic subunit Pph21p or Pph22p; required for cell morphogenesis and transcription by RNA polymerase III [Source:SGD;Acc:S000000014]
A	YAL017W	PSK1	997	-2914.9	4	One of two (see also PSK2) PAS domain containing S/T protein kinases; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status [Source:SGD;Acc:S000000015]
A	YAL018C	LDS1	12	-28.7	2	Putative protein of unknown function [Source:SGD;Acc:S000000016]
A	YAL019W	FUN30	1146	-529.2	4	Conserved member of the Snf2p family with ATP-dependent chromatin remodeling activity; has a role in silencing; potential Cdc28p substrate; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000017]
A	YAL019W-A	YAL019W-A	14	-7.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028729]
A	YAL020C	ATS1	117	-88.1	4	Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle [Source:SGD;Acc:S000000018]
A	YAL021C	CCR4	1321	-580.1	4	Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening [Source:SGD;Acc:S000000019]
A	YAL022C	FUN26	305	-119.3	4	Vacuolar membrane transporter with broad nucleoside selectivity; may regulate balance of nicotinamide riboside (NmR) levels between cytosol and vacuole, contributing to salvage of NmR for use in cytosolic NAD+ synthesis [Source:SGD;Acc:S000000020]
A	YAL023C	PMT2	1895	-543.7	4	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein Ser/Thr residues; involved in ER quality control; acts in a complex with Pmt1p, can instead interact with Pmt5; target for new antifungal [Source:SGD;Acc:S000000021]
A	YAL024C	LTE1	410	-436.1	4	Protein similar to GDP/GTP exchange factors but without detectable GEF activity; required for asymmetric localization of Bfa1p at daughter-directed spindle pole bodies and for mitotic exit at low temperatures [Source:SGD;Acc:S000000022]
A	YAL025C	MAK16	883	-114.7	4	Essential nuclear protein, constituent of 66S pre-ribosomal particles; required for maturation of 25S and 5.8S rRNAs; required for maintenance of M1 satellite double-stranded RNA of the L-A virus [Source:SGD;Acc:S000000023]
A	YAL026C	DRS2	561	-640.9	4	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; contributes to clathrin-coated vesicle formation and endocytosis; mutations in human homolog ATP8B1 result in liver disease [Source:SGD;Acc:S000000024]
A	YAL026C-A	YAL026C-A	6	-2.8	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAL027W and the verified gene DRS2 [Source:SGD;Acc:S000028730]
A	YAL027W	SAW1	66	-47	4	Protein involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during double-strand break repair via single-strand annealing; green fluorescent protein (GFP)-fusion protein localizes to the nucleus [Source:SGD;Acc:S000000025]
A	YAL028W	FRT2	57	-56.3	4	Tail-anchored ER membrane protein, interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate [Source:SGD;Acc:S000000026]
A	YAL029C	MYO4	1004	-676.8	4	One of two type V myosin motors (along with MYO2) involved in actin-based transport of cargos; required for mRNA transport, including ASH1 mRNA, and facilitating the growth and movement of ER tubules into the growing bud along with She3p [Source:SGD;Acc:S000000027]
A	YAL030W	SNC1	531	-89.7	4	Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins [Source:SGD;Acc:S000000028]
A	YAL031C	GIP4	452	-198.6	4	Cytoplasmic Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; potential Cdc28p substrate [Source:SGD;Acc:S000000029]
A	YAL031W-A	YAL031W-A	2	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028731]
A	YAL032C	PRP45	200	-227	4	Protein required for pre-mRNA splicing; associates with the spliceosome and interacts with splicing factors Prp22p and Prp46p; orthologous to human transcriptional coactivator SKIP and can activate transcription of a reporter gene [Source:SGD;Acc:S000000030]
A	YAL033W	POP5	196	-96.9	4	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs [Source:SGD;Acc:S000000031]
A	YAL034C	FUN19	164	-228.5	4	Non-essential protein of unknown function; expression induced in response to heat stress [Source:SGD;Acc:S000002134]
A	YAL034C-B	YAL034C-B	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002137]
A	YAL034W-A	MTW1	130	-136	4	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; critical to kinetochore assembly [Source:SGD;Acc:S000000032]
A	YAL035W	FUN12	3063	-1002.7	4	GTPase, required for general translation initiation by promoting Met-tRNAiMet binding to ribosomes and ribosomal subunit joining; homolog of bacterial IF2 [Source:SGD;Acc:S000000033]
A	YAL036C	RBG1	1743	-360.6	4	Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid [Source:SGD;Acc:S000000034]
A	YAL037C-A	YAL037C-A	3	-5.4	2	Putative protein of unknown function [Source:SGD;Acc:S000028732]
A	YAL037C-B	YAL037C-B	0	nf	1	Dubious open reading frame unlikely to encode a protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028592]
A	YAL037W	YAL037W	19	-4.9	2	Putative protein of unknown function [Source:SGD;Acc:S000000035]
A	YAL038W	CDC19	7059	-3661.3	4	Pyruvate kinase, functions as a homotetramer in glycolysis to convert phosphoenolpyruvate to pyruvate, the input for aerobic (TCA cycle) or anaerobic (glucose fermentation) respiration [Source:SGD;Acc:S000000036]
A	YAL039C	CYC3	301	-132.4	4	Cytochrome c heme lyase (holocytochrome c synthase), attaches heme to apo-cytochrome c (Cyc1p or Cyc7p) in the mitochondrial intermembrane space; human ortholog may have a role in microphthalmia with linear skin defects (MLS) [Source:SGD;Acc:S000000037]
A	YAL040C	CLN3	18	-557	4	G1 cyclin involved in cell cycle progression; activates Cdc28p kinase to promote the G1 to S phase transition; plays a role in regulating transcription of the other G1 cyclins, CLN1 and CLN2; regulated by phosphorylation and proteolysis [Source:SGD;Acc:S000000038]
A	YAL041W	CDC24	663	-1332.6	4	Guanine nucleotide exchange factor (GEF or GDP-release factor) for Cdc42p; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing [Source:SGD;Acc:S000000039]
A	YAL042C-A	YAL042C-A	8	-2.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ERV46/YAL042W; YAL042C-A is a non-essential gene [Source:SGD;Acc:S000002138]
A	YAL042W	ERV46	1332	-318.1	4	Protein localized to COPII-coated vesicles, forms a complex with Erv41p; involved in the membrane fusion stage of transport [Source:SGD;Acc:S000000040]
A	YAL043C	PTA1	820	-500.9	4	Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII [Source:SGD;Acc:S000000041]
A	YAL044C	GCV3	1468	-193.6	4	H subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; also required for all protein lipoylation; expression is regulated by levels of 5,10-methylene-THF [Source:SGD;Acc:S000000042]
A	YAL044W-A	YAL044W-A	259	-56.4	4	Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein [Source:SGD;Acc:S000007586]
A	YAL045C	YAL045C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps YAL044W-A [Source:SGD;Acc:S000000043]
A	YAL046C	AIM1	274	-86.1	4	Protein involved in mitochondrial function or organization; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000000044]
A	YAL047C	SPC72	200	-381.2	4	Component of the cytoplasmic Tub4p (gamma-tubulin) complex, binds spindle pole bodies and links them to microtubules; has roles in astral microtubule formation and stabilization [Source:SGD;Acc:S000000045]
A	YAL047W-A	YAL047W-A	2	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028733]
A	YAL048C	GEM1	295	-173.4	4	Evolutionarily-conserved tail-anchored outer mitochondrial membrane GTPase which regulates mitochondrial morphology; cells lacking Gem1p contain collapsed, globular, or grape-like mitochondria; not required for pheromone-induced cell death [Source:SGD;Acc:S000000046]
A	YAL049C	AIM2	923	-413.2	4	Cytoplasmic protein involved in mitochondrial function or organization; null mutant displays reduced frequency of mitochondrial genome loss; potential Hsp82p interactor [Source:SGD;Acc:S000000047]
A	YAL051W	OAF1	299	-156.8	4	Oleate-activated transcription factor, acts alone and as a heterodimer with Pip2p; activates genes involved in beta-oxidation of fatty acids and peroxisome organization and biogenesis [Source:SGD;Acc:S000000048]
A	YAL053W	FLC2	701	-309.1	4	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance [Source:SGD;Acc:S000000049]
A	YAL054C	ACS1	958	-1545.8	4	Acetyl-coA synthetase isoform which, along with Acs2p, is the nuclear source of acetyl-coA for histone acetylation; expressed during growth on nonfermentable carbon sources and under aerobic conditions [Source:SGD;Acc:S000000050]
A	YAL055W	PEX22	128	-86.3	4	Putative peroxisomal membrane protein required for import of peroxisomal proteins, functionally complements a Pichia pastoris pex22 mutation [Source:SGD;Acc:S000000051]
A	YAL056C-A	YAL056C-A	8	-10.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002139]
A	YAL056W	GPB2	224	-214.6	4	Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; inhibits Ras activity through direct interactions with Ira1p/2p; regulated by G-alpha protein Gpa2p; homolog of Gpb1p [Source:SGD;Acc:S000000052]
A	YAL058W	CNE1	171	-156.2	4	Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast [Source:SGD;Acc:S000000054]
A	YAL059C-A	YAL059C-A	5	-2.5	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene ECM1/YAL059W [Source:SGD;Acc:S000028734]
A	YAL059W	ECM1	542	-125.1	4	Pre-ribosomal factor involved in 60S ribosomal protein subunit export; associates with the pre-60S particle; shuttles between the nucleus and cytoplasm [Source:SGD;Acc:S000000055]
A	YAL060W	BDH1	1071	-539.7	4	NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source [Source:SGD;Acc:S000000056]
A	YAL061W	BDH2	231	-411.2	4	Putative medium-chain alcohol dehydrogenase with similarity to BDH1; transcription induced by constitutively active PDR1 and PDR3 [Source:SGD;Acc:S000000057]
A	YAL062W	GDH3	2680	-875.9	4	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh1p; expression regulated by nitrogen and carbon sources [Source:SGD;Acc:S000000058]
A	YAL063C	FLO9	11	-9.3	2	Lectin-like protein with similarity to Flo1p, thought to be expressed and involved in flocculation [Source:SGD;Acc:S000000059]
A	YAL063C-A	YAL063C-A	5	-3.3	2	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028813]
A	YAL064C-A	TDA8	0	nf	1	Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene [Source:SGD;Acc:S000002140]
A	YAL064W	YAL064W	1	-1.1	1	Protein of unknown function; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000000060]
A	YAL064W-B	YAL064W-B	1	-1	1	Fungal-specific protein of unknown function [Source:SGD;Acc:S000002141]
A	YAL065C	YAL065C	3	-2.2	2	Putative protein of unknown function; has homology to FLO1; possible pseudogene [Source:SGD;Acc:S000001817]
A	YAL066W	YAL066W	18	-28	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000061]
A	YAL067C	SEO1	26	-22.9	4	Putative permease, member of the allantoate transporter subfamily of the major facilitator superfamily; mutation confers resistance to ethionine sulfoxide [Source:SGD;Acc:S000000062]
A	YAL067W-A	YAL067W-A	15	-14.8	2	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028593]
A	YAL068C	PAU8	2	-1.1	1	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions [Source:SGD;Acc:S000002142]
A	YAL068W-A	YAL068W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028594]
A	YAL069W	YAL069W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002143]
A	YAR002C-A	ERP1	1452	-249.1	4	Protein that forms a heterotrimeric complex with Erp2p, Emp24p, and Erv25p; member, along with Emp24p and Erv25p, of the p24 family involved in ER to Golgi transport and localized to COPII-coated vesicles [Source:SGD;Acc:S000002129]
A	YAR002W	NUP60	1799	-681	4	Subunit of the nuclear pore complex (NPC), functions to anchor Nup2p to the NPC in a process controlled by the nucleoplasmic concentration of Gsp1p-GTP; involved in nuclear export and cytoplasmic localization of specific mRNAs such as ASH1 [Source:SGD;Acc:S000000063]
A	YAR003W	SWD1	156	-158.9	4	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member with similarity to mammalian Rbbp7 [Source:SGD;Acc:S000000064]
A	YAR007C	RFA1	1646	-604.2	4	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination [Source:SGD;Acc:S000000065]
A	YAR008W	SEN34	72	-68.3	4	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen34p contains the active site for tRNA 3' splice site cleavage and has similarity to Sen2p and to Archaeal tRNA splicing endonuclease [Source:SGD;Acc:S000000066]
A	YAR009C	YAR009C	2889	-956.5	4	Retrotransposon TYA Gag and TYB Pol genes; in YARCTY1-1 TYB is mutant and probably non-functional [Source:SGD;Acc:S000000067]
A	YAR010C	YAR010C	4694	-1783.9	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; in YARCTY1-1 TYB is mutant and probably non-functional [Source:SGD;Acc:S000000068]
A	YAR014C	BUD14	686	-532.3	4	Protein involved in bud-site selection, Bud14p-Glc7p complex is a cortical regulator of dynein; inhibitor of the actin assembly factor Bnr1p (formin); diploid mutants display a random budding pattern instead of the wild-type bipolar pattern [Source:SGD;Acc:S000000069]
A	YAR015W	ADE1	1988	-562.6	4	N-succinyl-5-aminoimidazole-4-carboxamide ribotide (SAICAR) synthetase, required for 'de novo' purine nucleotide biosynthesis; red pigment accumulates in mutant cells deprived of adenine [Source:SGD;Acc:S000000070]
A	YAR018C	KIN3	163	-1223.3	4	Nonessential serine/threonine protein kinase; possible role in DNA damage response [Source:SGD;Acc:S000000071]
A	YAR019C	CDC15	305	-245.5	4	Protein kinase of the Mitotic Exit Network that is localized to the spindle pole bodies at late anaphase; promotes mitotic exit by directly switching on the kinase activity of Dbf2p; required for spindle disassembly after meiosis II [Source:SGD;Acc:S000000072]
A	YAR019W-A	YAR019W-A	2	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028735]
A	YAR020C	PAU7	7	-2.2	2	Member of the seripauperin multigene family, active during alcoholic fermentation, regulated by anaerobiosis, inhibited by oxygen, repressed by heme [Source:SGD;Acc:S000000073]
A	YAR023C	YAR023C	3	-11.3	2	Putative integral membrane protein, member of DUP240 gene family [Source:SGD;Acc:S000000074]
A	YAR027W	UIP3	258	-88.2	4	Putative integral membrane protein of unknown function; interacts with Ulp1p at the nuclear periphery; member of DUP240 gene family [Source:SGD;Acc:S000000075]
A	YAR028W	YAR028W	293	-73.6	4	Putative integral membrane protein, member of DUP240 gene family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000000076]
A	YAR029W	YAR029W	0	nf	1	Member of DUP240 gene family but contains no transmembrane domains; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000000077]
A	YAR030C	YAR030C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YAR029W and the verified gene PRM9 [Source:SGD;Acc:S000001821]
A	YAR031W	PRM9	118	-78.1	4	Pheromone-regulated protein with 3 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; member of DUP240 gene family [Source:SGD;Acc:S000000078]
A	YAR033W	MST28	150	-109.9	4	Putative integral membrane protein, involved in vesicle formation; forms complex with Mst27p; member of DUP240 gene family; binds COPI and COPII vesicles [Source:SGD;Acc:S000000079]
A	YAR035C-A	YAR035C-A	2	-2.6	2	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis [Source:SGD;Acc:S000028595]
A	YAR035W	YAT1	357	-1063.7	4	Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated [Source:SGD;Acc:S000000080]
A	YAR042W	SWH1	1311	-730.7	4	Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction [Source:SGD;Acc:S000000081]
A	YAR047C	YAR047C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000083]
A	YAR050W	FLO1	35	-45.4	3	Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p [Source:SGD;Acc:S000000084]
A	YAR053W	YAR053W	4	-5.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000085]
A	YAR060C	YAR060C	5	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000086]
A	YAR064W	YAR064W	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000000089]
A	YAR066W	YAR066W	23	-15.2	4	Putative GPI protein [Source:SGD;Acc:S000002144]
A	YAR068W	YAR068W	7	-2.1	2	Fungal-specific protein of unknown function; induced in respiratory-deficient cells [Source:SGD;Acc:S000000091]
A	YAR069C	YAR069C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000092]
A	YAR070C	YAR070C	1	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000093]
A	YAR071W	PHO11	839	-543.6	4	One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 [Source:SGD;Acc:S000000094]
A	YAR073W	IMD1	2974	-449.7	4	Nonfunctional protein with homology to IMP dehydrogenase; probable pseudogene, located close to the telomere; is not expressed at detectable levels; YAR073W and YAR075W comprise a continuous reading frame in some strains of S. cerevisiae [Source:SGD;Acc:S000000095]
A	YAR075W	YAR075W	1849	-337.2	4	Non-functional protein with homology IMP dehydrogenase; YAR073W/IMD1 and YAR075W comprise a continuous reading frame in some strains of S. cerevisiae. [Source:SGD;Acc:S000002145]
B	YBL001C	ECM15	274	-214	4	Non-essential protein of unknown function, likely exists as tetramer, may be regulated by the binding of small-molecule ligands (possibly sulfate ions), may have a role in yeast cell-wall biogenesis [Source:SGD;Acc:S000000097]
B	YBL002W	HTB2	3706	-428.2	4	Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB1; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation [Source:SGD;Acc:S000000098]
B	YBL003C	HTA2	2834	-485.5	4	Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical (see also HTA1) subtypes; DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p [Source:SGD;Acc:S000000099]
B	YBL004W	UTP20	1333	-1433	4	Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA [Source:SGD;Acc:S000000100]
B	YBL005W	PDR3	77	-97.4	4	Transcriptional activator of the pleiotropic drug resistance network, regulates expression of ATP-binding cassette (ABC) transporters through binding to cis-acting sites known as PDREs (PDR responsive elements); post-translationally up-regulated in   lacking a functional mitochondrial genome [Source:SGD;Acc:S000000101]
B	YBL005W-A	YBL005W-A	2672	-512.7	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000002146]
B	YBL005W-B	YBL005W-B	3777	-1398.5	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000002147]
B	YBL006C	LDB7	286	-96.6	4	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions [Source:SGD;Acc:S000000102]
B	YBL006W-A	YBL006W-A	2	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene LDB7/YBL006C [Source:SGD;Acc:S000028596]
B	YBL007C	SLA1	2271	-725.1	4	Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains [Source:SGD;Acc:S000000103]
B	YBL008W	HIR1	280	-137.3	4	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores [Source:SGD;Acc:S000000104]
B	YBL008W-A	YBL008W-A	47	-4.5	2	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028529]
B	YBL009W	ALK2	141	-1348.7	4	Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk1p and to mammalian haspins [Source:SGD;Acc:S000000105]
B	YBL010C	YBL010C	135	-102.8	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles [Source:SGD;Acc:S000000106]
B	YBL011W	SCT1	506	-295.7	4	Glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase of the glycerolipid biosynthesis pathway, prefers 16-carbon fatty acids, similar to Gpt2p, gene is constitutively transcribed [Source:SGD;Acc:S000000107]
B	YBL012C	YBL012C	2	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000108]
B	YBL013W	FMT1	152	-149.3	4	Methionyl-tRNA formyltransferase, catalyzes the formylation of initiator Met-tRNA in mitochondria; potential Cdc28p substrate [Source:SGD;Acc:S000000109]
B	YBL014C	RRN6	66	-61.5	3	Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p [Source:SGD;Acc:S000000110]
B	YBL015W	ACH1	1484	-1121.3	4	Protein with CoA transferase activity, particularly for CoASH transfer from succinyl-CoA to acetate; has minor acetyl-CoA-hydrolase activity; phosphorylated; required for acetate utilization and for diploid pseudohyphal growth [Source:SGD;Acc:S000000111]
B	YBL016W	FUS3	545	-893.6	4	Mitogen-activated serine/threonine protein kinase involved in mating; phosphoactivated by Ste7p; substrates include Ste12p, Far1p, Bni1p, Sst2p; inhibits invasive growth during mating by phosphorylating Tec1p, promoting its degradation [Source:SGD;Acc:S000000112]
B	YBL017C	PEP1	1656	-1263.7	4	Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments [Source:SGD;Acc:S000000113]
B	YBL018C	POP8	143	-134.1	4	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs [Source:SGD;Acc:S000000114]
B	YBL019W	APN2	81	-55.9	4	Class II abasic (AP) endonuclease involved in repair of DNA damage; homolog of human HAP1 and E. coli exoIII [Source:SGD;Acc:S000000115]
B	YBL020W	RFT1	172	-102.5	4	Essential integral membrane protein that is required for translocation of Man5GlcNac2-PP-Dol from the cytoplasmic side to the lumenal side of the ER membrane but is not the flippase; mutation is suppressed by expression of human p53 protein [Source:SGD;Acc:S000000116]
B	YBL021C	HAP3	47	-34.3	4	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding [Source:SGD;Acc:S000000117]
B	YBL022C	PIM1	1573	-1039.9	4	ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria [Source:SGD;Acc:S000000118]
B	YBL023C	MCM2	822	-709.5	4	Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex [Source:SGD;Acc:S000000119]
B	YBL024W	NCL1	2546	-797.7	4	S-adenosyl-L-methionine-dependent tRNA: m5C-methyltransferase, methylates cytosine to m5C at several positions in tRNAs and intron-containing pre-tRNAs; similar to Nop2p and human proliferation associated nucleolar protein p120 [Source:SGD;Acc:S000000120]
B	YBL025W	RRN10	63	-84.5	4	Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I [Source:SGD;Acc:S000000121]
B	YBL026W	LSM2	1385	-234.6	4	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA [Source:SGD;Acc:S000000122]
B	YBL027W	RPL19B	4494	-597.3	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Ap and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal [Source:SGD;Acc:S000000123]
B	YBL028C	YBL028C	196	-119.6	4	Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000000124]
B	YBL029C-A	YBL029C-A	264	-78.3	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; has potential orthologs in Saccharomyces species and in Yarrowia lipolytica [Source:SGD;Acc:S000007591]
B	YBL029W	YBL029W	18	-67.9	2	Non-essential protein of unknown function [Source:SGD;Acc:S000000125]
B	YBL030C	PET9	3696	-1098.4	4	Major ADP/ATP carrier of the mitochondrial inner membrane, exchanges cytosolic ADP for mitochondrially synthesized ATP; also imports heme and ATP; phosphorylated; required for viability in many lab strains that carry a sal1 mutation [Source:SGD;Acc:S000000126]
B	YBL031W	SHE1	154	-59.7	4	Mitotic spindle protein that interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure [Source:SGD;Acc:S000000127]
B	YBL032W	HEK2	1597	-235.1	4	RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K [Source:SGD;Acc:S000000128]
B	YBL033C	RIB1	711	-206.7	4	GTP cyclohydrolase II; catalyzes the first step of the riboflavin biosynthesis pathway [Source:SGD;Acc:S000000129]
B	YBL034C	STU1	363	-403.6	4	Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles [Source:SGD;Acc:S000000130]
B	YBL035C	POL12	648	-296	4	B subunit of DNA polymerase alpha-primase complex, required for initiation of DNA replication during mitotic and premeiotic DNA synthesis; also functions in telomere capping and length regulation [Source:SGD;Acc:S000000131]
B	YBL036C	YBL036C	1399	-276.6	4	Putative non-specific single-domain racemase based on structural similarity; binds pyridoxal 5'-phosphate; expression of GFP-fusion protein induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000000132]
B	YBL037W	APL3	897	-488.6	4	Alpha-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport [Source:SGD;Acc:S000000133]
B	YBL038W	MRPL16	239	-56.4	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000000134]
B	YBL039C	URA7	2614	-923.3	4	Major CTP synthase isozyme (see also URA8), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis [Source:SGD;Acc:S000000135]
B	YBL039C-A	YBL039C-A	1	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF URA7; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028814]
B	YBL039W-B	YBL039W-B	24	-12.6	4	Putative protein of unknown function [Source:SGD;Acc:S000028517]
B	YBL040C	ERD2	163	-49.9	4	HDEL receptor, an integral membrane protein that binds to the HDEL motif in proteins destined for retention in the endoplasmic reticulum; has a role in maintenance of normal levels of ER-resident proteins [Source:SGD;Acc:S000000136]
B	YBL041W	PRE7	1588	-250.6	4	Beta 6 subunit of the 20S proteasome [Source:SGD;Acc:S000000137]
B	YBL042C	FUI1	332	-179	4	High affinity uridine permease, localizes to the plasma membrane; also mediates low but significant transport of the cytotoxic nucleoside analog 5-fluorouridine; not involved in uracil transport [Source:SGD;Acc:S000000138]
B	YBL043W	ECM13	9	-14.6	2	Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000000139]
B	YBL044W	YBL044W	5	-2	1	Putative protein of unknown function; YBL044W is not an essential protein [Source:SGD;Acc:S000000140]
B	YBL045C	COR1	2353	-1071.1	4	Core subunit of the ubiquinol-cytochrome c reductase complex (bc1 complex), which is a component of the mitochondrial inner membrane electron transport chain [Source:SGD;Acc:S000000141]
B	YBL046W	PSY4	324	-195.3	4	Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recover   the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2 [Source:SGD;Acc:S000000142]
B	YBL047C	EDE1	2966	-2118.2	4	Key endocytic protein involved in a network of interactions with other endocytic proteins, binds membranes in a ubiquitin-dependent manner, may also bind ubiquitinated membrane-associated proteins [Source:SGD;Acc:S000000143]
B	YBL048W	RRT1	5	-1.9	1	Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000000144]
B	YBL049W	MOH1	42	-33.5	4	Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase [Source:SGD;Acc:S000000145]
B	YBL050W	SEC17	1790	-304.8	4	Peripheral membrane protein required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, and autophagy; stimulates the ATPase activity of Sec18p; has similarity to mammalian alpha-SNAP [Source:SGD;Acc:S000000146]
B	YBL051C	PIN4	1232	-557.4	4	Protein involved in G2/M phase progression and response to DNA damage, interacts with Rad53p; contains an RNA recognition motif, a nuclear localization signal, and several SQ/TQ cluster domains; hyperphosphorylated in response to DNA damage [Source:SGD;Acc:S000000147]
B	YBL052C	SAS3	171	-91.9	4	Histone acetyltransferase catalytic subunit of NuA3 complex that acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal [Source:SGD;Acc:S000000148]
B	YBL053W	YBL053W	1	-1.7	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000149]
B	YBL054W	TOD6	455	-150.1	4	PAC motif binding protein involved in rRNA and ribosome biogenesis; subunit of the RPD3L histone deacetylase complex; Myb-like HTH transcription factor, similar to Dot6p; hypophosphorylated by rapamycin treatment in a Sch9p-dependent manne [Source:SGD;Acc:S000000150]
B	YBL055C	YBL055C	469	-268.9	4	3'-->5' exonuclease and endonuclease with a possible role in apoptosis; has similarity to mammalian and C. elegans apoptotic nucleases [Source:SGD;Acc:S000000151]
B	YBL056W	PTC3	1148	-475.2	4	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p (see also Ptc2p) to limit maximal kinase activity induced by osmotic stress; dephosphorylates T169 phosphorylated Cdc28p (see also Ptc2p); role in DNA damage checkpoint inactivation [Source:SGD;Acc:S000000152]
B	YBL057C	PTH2	786	-136.8	4	One of two (see also PTH1) mitochondrially-localized peptidyl-tRNA hydrolases; negatively regulates the ubiquitin-proteasome pathway via interactions with ubiquitin-like ubiquitin-associated proteins; dispensable for cell growth [Source:SGD;Acc:S000000153]
B	YBL058W	SHP1	2161	-383.1	4	UBX (ubiquitin regulatory X) domain-containing protein that regulates Glc7p phosphatase activity and interacts with Cdc48p; interacts with ubiquitylated proteins in vivo and is required for degradation of a ubiquitylated model substrate [Source:SGD;Acc:S000000154]
B	YBL059C-A	CMC2	297	-171.1	4	Protein of the mitochondrial intermembrane space with a role in respiratory chain complex assembly or maintenance; contains twin Cx9C motifs that can form coiled coil-helix-coiled-coil helix fold [Source:SGD;Acc:S000007488]
B	YBL059W	YBL059W	70	-107.4	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000155]
B	YBL060W	YEL1	169	-123.7	4	Guanine nucleotide exchange factor specific for Arf3p; localized to the bud neck and tip; required for localization of Arf3p to the bud neck and tip [Source:SGD;Acc:S000000156]
B	YBL061C	SKT5	567	-281.1	4	Activator of Chs3p (chitin synthase III), recruits Chs3p to the bud neck via interaction with Bni4p; has similarity to Shc1p, which activates Chs3p during sporulation [Source:SGD;Acc:S000000157]
B	YBL062W	YBL062W	4	-1.5	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000158]
B	YBL063W	KIP1	155	-137.7	4	Kinesin-related motor protein required for mitotic spindle assembly, chromosome segregation, and 2 micron plasmid partitioning; functionally redundant with Cin8p for chromosomal but not plasmid functions [Source:SGD;Acc:S000000159]
B	YBL064C	PRX1	1572	-322.4	4	Mitochondrial peroxiredoxin (1-Cys Prx) with thioredoxin peroxidase activity, has a role in reduction of hydroperoxides; reactivation requires Trr2p and glutathione; induced during respiratory growth and oxidative stress; phosphorylated [Source:SGD;Acc:S000000160]
B	YBL065W	YBL065W	4	-2.7	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene [Source:SGD;Acc:S000000161]
B	YBL066C	SEF1	513	-733.6	4	Putative transcription factor, has homolog in Kluyveromyces lactis [Source:SGD;Acc:S000000162]
B	YBL067C	UBP13	465	-268.1	4	Putative ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions [Source:SGD;Acc:S000000163]
B	YBL068W	PRS4	1088	-301.9	4	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes [Source:SGD;Acc:S000000164]
B	YBL068W-A	YBL068W-A	194	-43.6	4	Dubious open reading frame unlikely to encode a protein; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028530]
B	YBL069W	AST1	505	-221.4	4	Peripheral membrane protein that interacts with the plasma membrane ATPase Pma1p and has a role in its targeting to the plasma membrane, possibly by influencing its incorporation into lipid rafts [Source:SGD;Acc:S000000165]
B	YBL070C	YBL070C	4	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000166]
B	YBL071C	YBL071C	3	-2.2	2	Dubious open reading frame, predicted protein contains a peroxisomal targeting signal [Source:SGD;Acc:S000000167]
B	YBL071C-B	YBL071C-B	2	-1.2	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028597]
B	YBL071W-A	KTI11	32	-37.9	4	Zn-ribbon protein that co-purifies with Dph1 and Dph2 in a complex required for synthesis of diphthamide on translation factor eEF2 and with Elongator subunits Iki3p, Elp2p, and Elp3p involved in modification of wobble nucleosides in tRNAs [Source:SGD;Acc:S000007587]
B	YBL072C	RPS8A	4280	-680.1	4	Protein component of the small (40S) ribosomal subunit; identical to Rps8Bp and has similarity to rat S8 ribosomal protein [Source:SGD;Acc:S000000168]
B	YBL073W	YBL073W	10	-2.5	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene AAR2/YBL074C [Source:SGD;Acc:S000000169]
B	YBL074C	AAR2	121	-140.1	4	Component of the U5 snRNP, required for splicing of U3 precursors; originally described as a splicing factor specifically required for splicing pre-mRNA of the MATa1 cistron [Source:SGD;Acc:S000000170]
B	YBL075C	SSA3	6628	-1520.9	4	ATPase involved in protein folding and the response to stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm [Source:SGD;Acc:S000000171]
B	YBL076C	ILS1	3474	-1967.8	4	Cytoplasmic isoleucine-tRNA synthetase, target of the G1-specific inhibitor reveromycin A [Source:SGD;Acc:S000000172]
B	YBL077W	YBL077W	5	-2.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ILS1/YBL076C [Source:SGD;Acc:S000000173]
B	YBL078C	ATG8	308	-132.4	4	Component of autophagosomes and Cvt vesicles; undergoes conjugation to phosphatidylethanolamine (PE); Atg8p-PE is anchored to membranes, is involved in phagophore expansion, and may mediate membrane fusion during autophagosome formation [Source:SGD;Acc:S000000174]
B	YBL079W	NUP170	1381	-2183	4	Subunit of the nuclear pore complex (NPC), required for NPC localization of specific nucleoporins; involved in nuclear envelope permeability and chromosome segregation; has similar to Nup157p; essential role, with Nup157p, in NPC assembly [Source:SGD;Acc:S000000175]
B	YBL080C	PET112	163	-177.1	4	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; mutation is functionally complemented by the bacterial GatB ortholog [Source:SGD;Acc:S000000176]
B	YBL081W	YBL081W	128	-47.8	4	Non-essential protein of unknown function; null mutation results in a decrease in plasma membrane electron transport [Source:SGD;Acc:S000000177]
B	YBL082C	ALG3	97	-84.9	4	Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins [Source:SGD;Acc:S000000178]
B	YBL083C	YBL083C	2	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified ORF ALG3 [Source:SGD;Acc:S000000179]
B	YBL084C	CDC27	211	-361.8	4	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [Source:SGD;Acc:S000000180]
B	YBL085W	BOI1	1077	-485.9	4	Protein implicated in polar growth, functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain [Source:SGD;Acc:S000000181]
B	YBL086C	YBL086C	404	-221.4	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000000182]
B	YBL087C	RPL23A	3793	-481.5	4	Protein component of the large (60S) ribosomal subunit, identical to Rpl23Bp and has similarity to E. coli L14 and rat L23 ribosomal proteins [Source:SGD;Acc:S000000183]
B	YBL088C	TEL1	93	-561.3	4	Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; homolog of human ataxia telangiectasia (ATM) gene [Source:SGD;Acc:S000000184]
B	YBL089W	AVT5	25	-30.1	4	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters [Source:SGD;Acc:S000000185]
B	YBL090W	MRP21	307	-100	4	Mitochondrial ribosomal protein of the small subunit; MRP21 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences [Source:SGD;Acc:S000000186]
B	YBL091C	MAP2	1950	-644	4	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p [Source:SGD;Acc:S000000187]
B	YBL091C-A	SCS22	57	-32.2	4	Protein involved in regulation of phospholipid metabolism; homolog of Scs2p; similar to D. melanogaster inturned protein [Source:SGD;Acc:S000007228]
B	YBL092W	RPL32	3475	-322.8	4	Protein component of the large (60S) ribosomal subunit, has similarity to rat L32 ribosomal protein; overexpression disrupts telomeric silencing [Source:SGD;Acc:S000000188]
B	YBL093C	ROX3	67	-46.5	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme [Source:SGD;Acc:S000000189]
B	YBL094C	YBL094C	3	-1.7	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YBL095W [Source:SGD;Acc:S000000190]
B	YBL095W	YBL095W	152	-117.5	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000191]
B	YBL096C	YBL096C	1	-2.1	2	Non-essential protein of unknown function [Source:SGD;Acc:S000000192]
B	YBL097W	BRN1	286	-277.3	4	Subunit of the condensin complex; required for chromosome condensation and for clustering of tRNA genes at the nucleolus; may influence multiple aspects of chromosome transmission [Source:SGD;Acc:S000000193]
B	YBL098W	BNA4	538	-465.6	4	Kynurenine 3-mono oxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p; putative therapeutic target for Huntington disease [Source:SGD;Acc:S000000194]
B	YBL099W	ATP1	4389	-1781.2	4	Alpha subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated [Source:SGD;Acc:S000000195]
B	YBL100C	YBL100C	2	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the 5' end of ATP1 [Source:SGD;Acc:S000000196]
B	YBL100W-A	YBL100W-A	980	-342.4	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000002148]
B	YBL100W-B	YBL100W-B	2252	-709.6	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000002149]
B	YBL100W-C	YBL100W-C	1	-1.1	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028598]
B	YBL101C	ECM21	1122	-652.3	4	Protein involved in regulating the endocytosis of plasma membrane proteins; identified as a substrate for ubiquitination by Rsp5p and deubiquitination by Ubp2p; promoter contains several Gcn4p binding elements [Source:SGD;Acc:S000000197]
B	YBL102W	SFT2	705	-111	4	Non-essential tetra-spanning membrane protein found mostly in the late Golgi, can suppress some sed5 alleles; may be part of the transport machinery, but precise function is unknown; similar to mammalian syntaxin 5 [Source:SGD;Acc:S000000198]
B	YBL103C	RTG3	502	-1781.5	4	Basic helix-loop-helix-leucine zipper (bHLH/Zip) transcription factor that forms a complex with another bHLH/Zip protein, Rtg1p, to activate the retrograde (RTG) and TOR pathways [Source:SGD;Acc:S000000199]
B	YBL104C	SEA4	564	-449	4	Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has an N-terminal beta-propeller fold and a C-terminal RING motif; promoter contains multiple GCN4 binding sites [Source:SGD;Acc:S000000200]
B	YBL105C	PKC1	1000	-1787.1	4	Protein serine/threonine kinase essential for cell wall remodeling during growth; localized to sites of polarized growth and the mother-daughter bud neck; homolog of the alpha, beta, and gamma isoforms of mammalian protein kinase C (PKC) [Source:SGD;Acc:S000000201]
B	YBL106C	SRO77	327	-56.5	4	Protein with roles in exocytosis and cation homeostasis; functions in docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro7p and Drosophila lethal giant larvae tumor suppressor; interacts with SNARE protein Sec9p [Source:SGD;Acc:S000000202]
B	YBL107C	MIX23	249	-121.6	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YBL107C is not an essential gene [Source:SGD;Acc:S000000203]
B	YBL107W-A	YBL107W-A	2	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the Ty2 LTR YBLWdelta2 [Source:SGD;Acc:S000007229]
B	YBL108C-A	PAU9	2	-1.1	1	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions [Source:SGD;Acc:S000007592]
B	YBL108W	YBL108W	8	-3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000204]
B	YBL109W	YBL109W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000002150]
B	YBL111C	YBL111C	256	-197.9	4	Helicase-like protein encoded within the telomeric Y' element [Source:SGD;Acc:S000002151]
B	YBL112C	YBL112C	71	-17.2	4	Putative protein of unknown function; YBL112C is contained within TEL02L [Source:SGD;Acc:S000002152]
B	YBL113C	YBL113C	174	-118.9	4	Helicase-like protein encoded within the telomeric Y' element [Source:SGD;Acc:S000002153]
B	YBL113W-A	YBL113W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028599]
B	YBR001C	NTH2	559	-346.5	4	Putative neutral trehalase, required for thermotolerance and may mediate resistance to other cellular stresses [Source:SGD;Acc:S000000205]
B	YBR002C	RER2	235	-138.6	4	Cis-prenyltransferase involved in dolichol synthesis; participates in endoplasmic reticulum (ER) protein sorting [Source:SGD;Acc:S000000206]
B	YBR003W	COQ1	681	-331.2	4	Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis [Source:SGD;Acc:S000000207]
B	YBR004C	GPI18	25	-52	4	Functional ortholog of human PIG-V, which is a mannosyltransferase that transfers the second mannose in glycosylphosphatidylinositol biosynthesis; the authentic, non-tagged protein was localized to mitochondria [Source:SGD;Acc:S000000208]
B	YBR005W	RCR1	219	-78.4	4	Protein of the ER membrane involved in cell wall chitin deposition; may function in the endosomal-vacuolar trafficking pathway, helping determine whether plasma membrane proteins are degraded or routed to the plasma membrane [Source:SGD;Acc:S000000209]
B	YBR006W	UGA2	724	-419	4	Succinate semialdehyde dehydrogenase involved in the utilization of gamma-aminobutyrate (GABA) as a nitrogen source; part of the 4-aminobutyrate and glutamate degradation pathways; localized to the cytoplasm [Source:SGD;Acc:S000000210]
B	YBR007C	DSF2	351	-85.1	4	Deletion suppressor of mpt5 mutation [Source:SGD;Acc:S000000211]
B	YBR008C	FLR1	7	-59.7	2	Plasma membrane multidrug transporter of the major facilitator superfamily, involved in efflux of fluconazole, diazaborine, benomyl, methotrexate, and other drugs; expression induced in cells treated with the mycotoxin patulin [Source:SGD;Acc:S000000212]
B	YBR009C	HHF1	3472	-385.3	4	Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF2); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity [Source:SGD;Acc:S000000213]
B	YBR010W	HHT1	1860	-246.2	4	Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT2); regulated by acetylation, methylation, and phosphorylation [Source:SGD;Acc:S000000214]
B	YBR011C	IPP1	3730	-714.7	4	Cytoplasmic inorganic pyrophosphatase (PPase), homodimer that catalyzes the rapid exchange of oxygens from Pi with water, highly expressed and essential for viability, active-site residues show identity to those from E. coli PPase [Source:SGD;Acc:S000000215]
B	YBR012C	YBR012C	0	nf	1	Dubious open reading frame, unlikely to encode a functional protein; expression induced by iron-regulated transcriptional activator Aft2p [Source:SGD;Acc:S000000216]
B	YBR012W-A	YBR012W-A	4510	-1569.9	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000002154]
B	YBR012W-B	YBR012W-B	4853	-2165.1	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000002155]
B	YBR013C	YBR013C	2	-5.2	2	Putative protein of unknown function, haploid deletion mutant exhibits synthetic phenotype with alpha-synuclein [Source:SGD;Acc:S000000217]
B	YBR014C	GRX7	433	-176.6	4	Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; functional overlap with GRX6 [Source:SGD;Acc:S000000218]
B	YBR015C	MNN2	1199	-589.9	4	Alpha-1,2-mannosyltransferase, responsible for addition of the first alpha-1,2-linked mannose to form the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment [Source:SGD;Acc:S000000219]
B	YBR016W	YBR016W	346	-218.3	4	Tail-anchored plasma membrane protein containing a conserved CYSTM module; predicted to be palmitoylated; has similarity to hydrophilins, which are involved in the adaptive response to hyperosmotic conditions [Source:SGD;Acc:S000000220]
B	YBR017C	KAP104	1379	-555.4	4	Transportin or cytosolic karyopherin beta 2; functions in the rg-nuclear localization signal-mediated nuclear import/reimport of mRNA-binding proteins Nab2p and Hrp1p; regulates asymmetric protein synthesis in daughter cells during mitosis [Source:SGD;Acc:S000000221]
B	YBR018C	GAL7	91	-608.5	4	Galactose-1-phosphate uridyl transferase, synthesizes glucose-1-phosphate and UDP-galactose from UDP-D-glucose and alpha-D-galactose-1-phosphate in the second step of galactose catabolism [Source:SGD;Acc:S000000222]
B	YBR019C	GAL10	298	-2009.9	4	UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers [Source:SGD;Acc:S000000223]
B	YBR020W	GAL1	364	-1694.7	4	Galactokinase, phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p [Source:SGD;Acc:S000000224]
B	YBR021W	FUR4	59	-44.4	4	Uracil permease, localized to the plasma membrane; expression is tightly regulated by uracil levels and environmental cues [Source:SGD;Acc:S000000225]
B	YBR022W	POA1	211	-74.8	4	Phosphatase that is highly specific for ADP-ribose 1''-phosphate, a tRNA splicing metabolite; may have a role in regulation of tRNA splicing [Source:SGD;Acc:S000000226]
B	YBR023C	CHS3	719	-324.8	4	Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan [Source:SGD;Acc:S000000227]
B	YBR024W	SCO2	272	-237.8	4	Protein anchored to the mitochondrial inner membrane, similar to Sco1p and may have a redundant function with Sco1p in delivery of copper to cytochrome c oxidase; interacts with Cox2p [Source:SGD;Acc:S000000228]
B	YBR025C	OLA1	3662	-1290.3	4	P-loop ATPase with similarity to human OLA1 and bacterial YchF; identified as specifically interacting with the proteasome; protein levels are induced by hydrogen peroxide [Source:SGD;Acc:S000000229]
B	YBR026C	ETR1	1396	-364.5	4	2-enoyl thioester reductase, member of the medium chain dehydrogenase/reductase family; localized to in mitochondria, where it has a probable role in fatty acid synthesis [Source:SGD;Acc:S000000230]
B	YBR027C	YBR027C	3	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000231]
B	YBR028C	YPK3	477	-856.5	4	An AGC kinase phosphorylated by cAMP-dependent protein kinase (PKA) in a TORC1-dependent manner [Source:SGD;Acc:S000000232]
B	YBR029C	CDS1	1014	-187.9	4	Phosphatidate cytidylyltransferase (CDP-diglyceride synthetase); an enzyme that catalyzes that conversion of CTP + phosphate into diphosphate + CDP-diaclglyerol, a critical step in the synthesis of all major yeast phospholipids [Source:SGD;Acc:S000000233]
B	YBR030W	RKM3	184	-144.6	4	Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 40); nuclear SET domain containing protein [Source:SGD;Acc:S000000234]
B	YBR031W	RPL4A	5575	-1953	4	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Bp and has similarity to E. coli L4 and rat L4 ribosomal proteins [Source:SGD;Acc:S000000235]
B	YBR032W	YBR032W	1	-1.7	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000000236]
B	YBR033W	EDS1	33	-136.9	4	Putative zinc cluster protein; YBR033W is not an essential gene [Source:SGD;Acc:S000000237]
B	YBR034C	HMT1	888	-287.7	4	Nuclear SAM-dependent mono- and asymmetric arginine dimethylating methyltransferase that modifies hnRNPs, including Npl3p and Hrp1p, affecting their activity and nuclear export; methylates U1 snRNP protein Snp1p and ribosomal protein Rps2p [Source:SGD;Acc:S000000238]
B	YBR035C	PDX3	1630	-350.5	4	Pyridoxine (pyridoxamine) phosphate oxidase, has homologs in E. coli and Myxococcus xanthus; transcription is under the general control of nitrogen metabolism [Source:SGD;Acc:S000000239]
B	YBR036C	CSG2	330	-103.4	4	Endoplasmic reticulum membrane protein, required for mannosylation of inositolphosphorylceramide and for growth at high calcium concentrations [Source:SGD;Acc:S000000240]
B	YBR037C	SCO1	369	-233.3	4	Copper-binding protein of the mitochondrial inner membrane, required for cytochrome c oxidase activity and respiration; may function to deliver copper to cytochrome c oxidase; has similarity to thioredoxins [Source:SGD;Acc:S000000241]
B	YBR038W	CHS2	377	-231.1	4	Chitin synthase II; catalyzes transfer of N-acetylglucosamine (GlcNAc) to chitin upon activation of zymogenic form; required for chitin synthesis in the primary septum during cytokinesis; localization regulated by Cdk1p during mitosis [Source:SGD;Acc:S000000242]
B	YBR039W	ATP3	2262	-514.9	4	Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis [Source:SGD;Acc:S000000243]
B	YBR040W	FIG1	38	-16.6	3	Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating [Source:SGD;Acc:S000000244]
B	YBR041W	FAT1	746	-363.4	4	Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids [Source:SGD;Acc:S000000245]
B	YBR042C	CST26	394	-149.3	4	Protein required for incorporation of stearic acid into phosphatidylinositol; affects chromosome stability when overexpressed [Source:SGD;Acc:S000000246]
B	YBR043C	QDR3	170	-66.6	4	Multidrug transporter of the major facilitator superfamily, has a role in polyamine homeostasis; expression is upregulated under polyamine stress; required for resistance to quinidine, barban, cisplatin, and bleomycin [Source:SGD;Acc:S000000247]
B	YBR044C	TCM62	228	-269.7	4	Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; putative chaperone [Source:SGD;Acc:S000000248]
B	YBR045C	GIP1	9	-9	2	Meiosis-specific regulatory subunit of the Glc7p protein phosphatase, regulates spore wall formation and septin organization, required for expression of some late meiotic genes and for normal localization of Glc7p [Source:SGD;Acc:S000000249]
B	YBR046C	ZTA1	825	-557.7	4	NADPH-dependent quinone reductase, GFP-tagged protein localizes to the cytoplasm and nucleus; has similarity to E. coli quinone oxidoreductase and to human zeta-crystallin [Source:SGD;Acc:S000000250]
B	YBR047W	FMP23	41	-34.5	4	Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000251]
B	YBR048W	RPS11B	4408	-391.3	4	Protein component of the small (40S) ribosomal subunit; identical to Rps11Ap and has similarity to E. coli S17 and rat S11 ribosomal proteins [Source:SGD;Acc:S000000252]
B	YBR049C	REB1	1264	-613.6	4	RNA polymerase I enhancer binding protein; DNA binding protein which binds to genes transcribed by both RNA polymerase I and RNA polymerase II; required for termination of RNA polymerase I transcription [Source:SGD;Acc:S000000253]
B	YBR050C	REG2	23	-86.3	4	Regulatory subunit of the Glc7p type-1 protein phosphatase; involved with Reg1p, Glc7p, and Snf1p in regulation of glucose-repressible genes, also involved in glucose-induced proteolysis of maltose permease [Source:SGD;Acc:S000000254]
B	YBR051W	YBR051W	8	-2.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partiallly overlaps the REG2/YBR050C regulatory subunit of the Glc7p type-1 protein phosphatase [Source:SGD;Acc:S000000255]
B	YBR052C	RFS1	1091	-246.2	4	Protein of unknown function; member of a flavodoxin-like fold protein family that includes Pst2p and Ycp4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000000256]
B	YBR053C	YBR053C	926	-332	4	Putative protein of unknown function; induced by cell wall perturbation [Source:SGD;Acc:S000000257]
B	YBR054W	YRO2	1504	-202.5	4	Protein of unknown function with similarity to archaeal rhodopsins; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies; transcriptionally regulated by Haa1p [Source:SGD;Acc:S000000258]
B	YBR055C	PRP6	302	-330.3	4	Splicing factor, component of the U4/U6-U5 snRNP complex [Source:SGD;Acc:S000000259]
B	YBR056C-B	YBR056C-B	2	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the dubious ORF YBR056W-A [Source:SGD;Acc:S000087087]
B	YBR056W	YBR056W	1012	-473.3	4	Putative cytoplasmic protein of unknown function [Source:SGD;Acc:S000000260]
B	YBR056W-A	YBR056W-A	3	-22.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR056C-B [Source:SGD;Acc:S000028736]
B	YBR057C	MUM2	248	-119.2	4	Cytoplasmic protein essential for meiotic DNA replication and sporulation; interacts with Orc2p, which is a component of the origin recognition complex [Source:SGD;Acc:S000000261]
B	YBR058C	UBP14	944	-498.2	4	Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T [Source:SGD;Acc:S000000262]
B	YBR058C-A	TSC3	209	-26.3	4	Protein that stimulates the activity of serine palmitoyltransferase (Lcb1p, Lcb2p) several-fold; involved in sphingolipid biosynthesis [Source:SGD;Acc:S000007521]
B	YBR059C	AKL1	1370	-2122.8	4	Ser-Thr protein kinase, member (with Ark1p and Prk1p) of the Ark kinase family; involved in endocytosis and actin cytoskeleton organization [Source:SGD;Acc:S000000263]
B	YBR060C	ORC2	362	-148	4	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; interacts with Spp1p and with trimethylated histone H3; phosphorylated by Cdc28p [Source:SGD;Acc:S000000264]
B	YBR061C	TRM7	412	-199.2	4	2'-O-ribose methyltransferase, methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop [Source:SGD;Acc:S000000265]
B	YBR062C	YBR062C	195	-86.2	4	Protein of unknown function that interacts with Msb2p; may play a role in activation of the filamentous growth pathway. [Source:SGD;Acc:S000000266]
B	YBR063C	YBR063C	17	-3.7	2	Putative protein of unknown function; YBR063C is not an essential gene [Source:SGD;Acc:S000000267]
B	YBR064W	YBR064W	3	-1.6	1	Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YBR063C [Source:SGD;Acc:S000000268]
B	YBR065C	ECM2	327	-194.6	4	Pre-mRNA splicing factor, facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome, function may be regulated by Slu7p [Source:SGD;Acc:S000000269]
B	YBR066C	NRG2	49	-26	4	Transcriptional repressor that mediates glucose repression and negatively regulates filamentous growth; has similarity to Nrg1p [Source:SGD;Acc:S000000270]
B	YBR067C	TIP1	21	-40.3	4	Major cell wall mannoprotein with possible lipase activity; transcription is induced by heat- and cold-shock; member of the Srp1p/Tip1p family of serine-alanine-rich proteins [Source:SGD;Acc:S000000271]
B	YBR068C	BAP2	580	-129.3	4	High-affinity leucine permease, functions as a branched-chain amino acid permease involved in the uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains [Source:SGD;Acc:S000000272]
B	YBR069C	TAT1	777	-122	4	Amino acid transport protein for valine, leucine, isoleucine, and tyrosine, low-affinity tryptophan and histidine transporter; overexpression confers FK506 and FTY720 resistance [Source:SGD;Acc:S000000273]
B	YBR070C	ALG14	54	-38.6	4	Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases [Source:SGD;Acc:S000000274]
B	YBR071W	YBR071W	126	-33.7	4	Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking [Source:SGD;Acc:S000000275]
B	YBR072C-A	YBR072C-A	13	-16.7	2	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028532]
B	YBR072W	HSP26	3054	-1028.4	4	Small heat shock protein (sHSP) with chaperone activity; forms hollow, sphere-shaped oligomers that suppress unfolded proteins aggregation; oligomer activation requires heat-induced conformational change; also has mRNA binding activity [Source:SGD;Acc:S000000276]
B	YBR073W	RDH54	624	-280.5	4	DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in recombinational repair of DNA double-strand breaks during mitosis and meiosis; proposed to be involved in crossover interference [Source:SGD;Acc:S000000277]
B	YBR074W	PFF1	641	-297.3	4	Putative metalloprotease [Source:SGD;Acc:S000000278]
B	YBR076C-A	YBR076C-A	0	nf	1	Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene ECM8; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028533]
B	YBR076W	ECM8	9	-5.2	2	Non-essential protein of unknown function [Source:SGD;Acc:S000000280]
B	YBR077C	SLM4	407	-96.5	4	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; gene exhibits synthetic genetic interaction with MSS4 [Source:SGD;Acc:S000000281]
B	YBR078W	ECM33	3107	-486.8	4	GPI-anchored protein of unknown function, has a possible role in apical bud growth; GPI-anchoring on the plasma membrane crucial to function; phosphorylated in mitochondria; similar to Sps2p and Pst1p [Source:SGD;Acc:S000000282]
B	YBR079C	RPG1	3333	-1173.9	4	eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation [Source:SGD;Acc:S000000283]
B	YBR080C	SEC18	1985	-653.5	4	ATPase required for vesicular transport between ER and Golgi, the 'priming' step in homotypic vacuole fusion, autophagy, and protein secretion; releases Sec17p from SNAP complexes; has similarity to mammalian NSF [Source:SGD;Acc:S000000284]
B	YBR081C	SPT7	773	-2203.4	4	Subunit of the SAGA transcriptional regulatory complex, involved in proper assembly of the complex; also present as a C-terminally truncated form in the SLIK/SALSA transcriptional regulatory complex [Source:SGD;Acc:S000000285]
B	YBR082C	UBC4	1451	-277.5	4	Ubiquitin-conjugating enzyme (E2), mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response [Source:SGD;Acc:S000000286]
B	YBR083W	TEC1	174	-260.8	4	Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upst  f filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member [Source:SGD;Acc:S000000287]
B	YBR084C-A	RPL19A	4494	-597.3	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl19Bp and has similarity to rat L19 ribosomal protein; rpl19a and rpl19b single null mutations result in slow growth, while the double null mutation is lethal [Source:SGD;Acc:S000002156]
B	YBR084W	MIS1	2593	-911.6	4	Mitochondrial C1-tetrahydrofolate synthase, involved in interconversion between different oxidation states of tetrahydrofolate (THF); provides activities of formyl-THF synthetase, methenyl-THF cyclohydrolase, and methylene-THF dehydrogenase [Source:SGD;Acc:S000000288]
B	YBR085C-A	YBR085C-A	1220	-147.7	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus [Source:SGD;Acc:S000007522]
B	YBR085W	AAC3	2790	-382.7	4	Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Pet9p and Aac1p; has roles in maintenance of viability and in respiration [Source:SGD;Acc:S000000289]
B	YBR086C	IST2	2501	-595.6	4	Plasma membrane protein that may be involved in osmotolerance, localizes to the mother cell in small-budded cells and to the bud in medium- and large-budded cells; mRNA is transported to the bud tip by an actomyosin-driven process [Source:SGD;Acc:S000000290]
B	YBR087W	RFC5	868	-361.9	4	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon [Source:SGD;Acc:S000000291]
B	YBR088C	POL30	1937	-322.7	4	Proliferating cell nuclear antigen (PCNA), functions as the sliding clamp for DNA polymerase delta; may function as a docking site for other proteins required for mitotic and meiotic chromosomal DNA replication and for DNA repair [Source:SGD;Acc:S000000292]
B	YBR089C-A	NHP6B	1010	-130.4	4	High-mobility group (HMG) protein that binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2 [Source:SGD;Acc:S000002157]
B	YBR089W	YBR089W	12	-3.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30 [Source:SGD;Acc:S000000293]
B	YBR090C	YBR090C	9	-2.2	2	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000000294]
B	YBR091C	TIM12	214	-61.7	4	Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins [Source:SGD;Acc:S000000295]
B	YBR092C	PHO3	1107	-714.7	4	Constitutively expressed acid phosphatase similar to Pho5p; brought to the cell surface by transport vesicles; hydrolyzes thiamin phosphates in the periplasmic space, increasing cellular thiamin uptake; expression is repressed by thiamin [Source:SGD;Acc:S000000296]
B	YBR093C	PHO5	739	-627	4	Repressible acid phosphatase (1 of 3) that also mediates extracellular nucleotide-derived phosphate hydrolysis; secretory pathway derived cell surface glycoprotein; induced by phosphate starvation and coordinately regulated by PHO4 and PHO2 [Source:SGD;Acc:S000000297]
B	YBR094W	PBY1	826	-407.7	4	Putative tubulin tyrosine ligase associated with P-bodies [Source:SGD;Acc:S000000298]
B	YBR095C	RXT2	459	-1088.9	4	Subunit of the histone deacetylase Rpd3L complex; possibly involved in cell fusion and invasive growth [Source:SGD;Acc:S000000299]
B	YBR096W	YBR096W	678	-194.9	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER [Source:SGD;Acc:S000000300]
B	YBR097W	VPS15	267	-342.5	4	Myristoylated serine/threonine protein kinase involved in vacuolar protein sorting; functions as a membrane-associated complex with Vps34p; active form recruits Vps34p to the Golgi membrane; interacts with the GDP-bound form of Gpa1p [Source:SGD;Acc:S000000301]
B	YBR098W	MMS4	170	-93.5	4	Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination [Source:SGD;Acc:S000000302]
B	YBR099C	YBR099C	1	-1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4 [Source:SGD;Acc:S000000303]
B	YBR101C	FES1	1436	-415.4	4	Hsp70 (Ssa1p) nucleotide exchange factor, cytosolic homolog of Sil1p, which is the nucleotide exchange factor for BiP (Kar2p) in the endoplasmic reticulum [Source:SGD;Acc:S000000305]
B	YBR102C	EXO84	827	-398.8	4	Essential protein with dual roles in spliceosome assembly and exocytosis; the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p) mediates polarized targeting of secretory vesicles to active sites of exocytosis [Source:SGD;Acc:S000000306]
B	YBR103C-A	YBR103C-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; identified by homology to related yeast [Source:SGD;Acc:S000007593]
B	YBR103W	SIF2	457	-388.2	4	WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus [Source:SGD;Acc:S000000307]
B	YBR104W	YMC2	171	-127.3	4	Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc1p [Source:SGD;Acc:S000000308]
B	YBR105C	VID24	228	-404.1	4	Peripheral membrane protein located at Vid (vacuole import and degradation) vesicles; regulates fructose-1,6-bisphosphatase (FBPase) targeting to the vacuole; promotes proteasome-dependent catabolite degradation of FBPase [Source:SGD;Acc:S000000309]
B	YBR106W	PHO88	2309	-276.1	4	Probable membrane protein, involved in phosphate transport; pho88 pho86 double null mutant exhibits enhanced synthesis of repressible acid phosphatase at high inorganic phosphate concentrations [Source:SGD;Acc:S000000310]
B	YBR107C	IML3	23	-52.6	4	Protein with a role in kinetochore function, localizes to the outer kinetochore in a Ctf19p-dependent manner, interacts with Chl4p and Ctf19p [Source:SGD;Acc:S000000311]
B	YBR108W	AIM3	750	-260.1	4	Protein interacting with Rvs167p; null mutant is viable and displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000000312]
B	YBR109C	CMD1	2356	-310.8	4	Calmodulin; Ca++ binding protein that regulates Ca++ independent processes (mitosis, bud growth, actin organization, endocytosis, etc.) and Ca++ dependent processes (stress-activated pathways), targets include Nuf1p, Myo2p and calcineurin [Source:SGD;Acc:S000000313]
B	YBR109W-A	YBR109W-A	4	-3.8	2	Putative protein of unknown function; questionable ORF from MIPS [Source:SGD;Acc:S000028737]
B	YBR110W	ALG1	341	-170	4	Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog [Source:SGD;Acc:S000000314]
B	YBR111C	YSA1	1281	-147.9	4	Nudix hydrolase family member with ADP-ribose pyrophosphatase activity; shown to metabolize O-acetyl-ADP-ribose to AMP and acetylated ribose 5'-phosphate [Source:SGD;Acc:S000000315]
B	YBR111W-A	SUS1	422	-455.4	4	Component of both the SAGA histone acetylase and TREX-2 complexes; interacts with RNA polymerase II; involved in mRNA export coupled transcription activation and elongation; involved in post-transcriptional tethering of active genes to the nuclear p  ry and to non-nascent mRNP [Source:SGD;Acc:S000028510]
B	YBR112C	CYC8	1809	-961.9	4	General transcriptional co-repressor, acts together with Tup1p; also acts as part of a transcriptional co-activator complex that recruits the SWI/SNF and SAGA complexes to promoters; can form the prion [OCT+] [Source:SGD;Acc:S000000316]
B	YBR113W	YBR113W	5	-16.5	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CYC8 [Source:SGD;Acc:S000000317]
B	YBR114W	RAD16	314	-90.2	4	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad7p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex [Source:SGD;Acc:S000000318]
B	YBR115C	LYS2	1363	-3167.6	4	Alpha aminoadipate reductase, catalyzes the reduction of alpha-aminoadipate to alpha-aminoadipate 6-semialdehyde, which is the fifth step in biosynthesis of lysine; activation requires posttranslational phosphopantetheinylation by Lys5p [Source:SGD;Acc:S000000319]
B	YBR116C	YBR116C	10	-2.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TKL2 [Source:SGD;Acc:S000000320]
B	YBR117C	TKL2	774	-681.6	4	Transketolase, similar to Tkl1p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids [Source:SGD;Acc:S000000321]
B	YBR118W	TEF2	7994	-2657.5	4	Translational elongation factor EF-1 alpha; also encoded by TEF1; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus [Source:SGD;Acc:S000000322]
B	YBR119W	MUD1	204	-317.5	4	U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing [Source:SGD;Acc:S000000323]
B	YBR120C	CBP6	452	-176.5	4	Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly   sized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex [Source:SGD;Acc:S000000324]
B	YBR121C	GRS1	3508	-1937.1	4	Cytoplasmic and mitochondrial glycyl-tRNA synthase that ligates glycine to the cognate anticodon bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation [Source:SGD;Acc:S000000325]
B	YBR121C-A	YBR121C-A	1	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely contianed within the verified gene GRS1; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028815]
B	YBR122C	MRPL36	336	-140.4	4	Mitochondrial ribosomal protein of the large subunit; overproduction suppresses mutations in the COX2 leader peptide-encoding region [Source:SGD;Acc:S000000326]
B	YBR123C	TFC1	502	-323.8	4	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes; human homolog is TFIIIC-63 [Source:SGD;Acc:S000000327]
B	YBR124W	YBR124W	8	-3.5	2	Putative protein of unknown function [Source:SGD;Acc:S000000328]
B	YBR125C	PTC4	398	-1028.8	4	Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity [Source:SGD;Acc:S000000329]
B	YBR126C	TPS1	2230	-1191.9	4	Synthase subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; also found in a monomeric form; expression is induced by the stress response and repressed by the Ras-cAMP pathway [Source:SGD;Acc:S000000330]
B	YBR126W-A	YBR126W-A	323	-101.4	4	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-B; identified by gene-trapping, microarray analysis, and genome-wide homology searches [Source:SGD;Acc:S000028600]
B	YBR126W-B	YBR126W-B	1	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YBR126W-A; Identified by SAGE [Source:SGD;Acc:S000028738]
B	YBR127C	VMA2	4493	-988.3	4	Subunit B of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; contains nucleotide binding sites; also detected in the cytoplasm [Source:SGD;Acc:S000000331]
B	YBR128C	ATG14	27	-27.2	4	Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; homolog of human Barkor [Source:SGD;Acc:S000000332]
B	YBR129C	OPY1	360	-207.4	4	Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000333]
B	YBR130C	SHE3	1037	-257.3	4	Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance [Source:SGD;Acc:S000000334]
B	YBR131C-A	YBR131C-A	2	-1.3	1	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR131W. Identified by gene-trapping, microarray analysis, and genome-wide homology searches [Source:SGD;Acc:S000028601]
B	YBR131W	CCZ1	99	-140	4	Protein involved in vacuolar assembly, essential for autophagy and the cytoplasm-to-vacuole pathway [Source:SGD;Acc:S000000335]
B	YBR132C	AGP2	134	-88.4	4	High affinity polyamine permease, preferentially uses spermidine over putrescine; expression is down-regulated by osmotic stress; plasma membrane carnitine transporter, also functions as a low-affinity amino acid permease [Source:SGD;Acc:S000000336]
B	YBR133C	HSL7	301	-265.4	4	Protein arginine N-methyltransferase that exhibits septin and Hsl1p-dependent bud neck localization and periodic Hsl1p-dependent phosphorylation; required along with Hsl1p for bud neck recruitment, phosphorylation, and degradation of Swe1p [Source:SGD;Acc:S000000337]
B	YBR134W	YBR134W	1	-1.1	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000338]
B	YBR135W	CKS1	480	-151.4	4	Cyclin-dependent protein kinase regulatory subunit and adaptor; modulates proteolysis of M-phase targets through interactions with the proteasome; role in transcriptional regulation, recruiting proteasomal subunits to target gene promoters [Source:SGD;Acc:S000000339]
B	YBR136W	MEC1	343	-1250.2	4	Genome integrity checkpoint protein and PI kinase superfamily member; signal transducer required for cell cycle arrest and transcriptional responses prompted by damaged or unreplicated DNA; monitors and participates in meiotic recombination [Source:SGD;Acc:S000000340]
B	YBR137W	YBR137W	530	-197.2	4	Protein of unknown function; localized to the cytoplasm; binds to Replication Protein A (RPA); also interacts with Sgt2p; YBR137W is not an essential gene [Source:SGD;Acc:S000000341]
B	YBR138C	YBR138C	54	-26.2	2	Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene [Source:SGD;Acc:S000000342]
B	YBR139W	YBR139W	692	-370.9	4	Putative serine type carboxypeptidase with a role in phytochelatin synthesis; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner [Source:SGD;Acc:S000000343]
B	YBR140C	IRA1	607	-986.8	4	GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, mediates membrane association of adenylate cyclase [Source:SGD;Acc:S000000344]
B	YBR141C	BMT2	79	-55.2	4	Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YBR141C is not an essential gene [Source:SGD;Acc:S000000345]
B	YBR141W-A	YBR141W-A	2	-2.8	2	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YBR141C; identified by gene-trapping, microarray analysis, and genome-wide homology searching [Source:SGD;Acc:S000028602]
B	YBR142W	MAK5	1401	-480.1	4	Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits [Source:SGD;Acc:S000000346]
B	YBR143C	SUP45	2728	-663.3	4	Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin [Source:SGD;Acc:S000000347]
B	YBR144C	YBR144C	7	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR144C is not an essential gene [Source:SGD;Acc:S000000348]
B	YBR145W	ADH5	3271	-393.1	4	Alcohol dehydrogenase isoenzyme V; involved in ethanol production [Source:SGD;Acc:S000000349]
B	YBR146W	MRPS9	628	-164.7	4	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000000350]
B	YBR147W	RTC2	3	-5.4	2	Protein of unknown function; mutant produces large lipid droplets, is resistant to fluconazole, has decreased levels of rDNA transcription, growth defects on minimal media, and suppresses cdc13-1; detected in highly purified mitochondria; similar to  rotein coupled receptor from S. pombe [Source:SGD;Acc:S000000351]
B	YBR148W	YSW1	39	-22.6	3	Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane [Source:SGD;Acc:S000000352]
B	YBR149W	ARA1	2042	-587.6	4	NADP+ dependent arabinose dehydrogenase, involved in carbohydrate metabolism; purified as homodimer; naturally occurs with a N-terminus degradation product [Source:SGD;Acc:S000000353]
B	YBR150C	TBS1	128	-202	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000354]
B	YBR151W	APD1	955	-293.7	4	Protein of unknown function, required for normal localization of actin patches and for normal tolerance of sodium ions and hydrogen peroxide; localizes to both cytoplasm and nucleus [Source:SGD;Acc:S000000355]
B	YBR152W	SPP381	142	-87.8	4	mRNA splicing factor, component of U4/U6.U5 tri-snRNP; interacts genetically and physically with Prp38p [Source:SGD;Acc:S000000356]
B	YBR153W	RIB7	72	-66.2	4	Diaminohydroxyphoshoribosylaminopyrimidine deaminase; catalyzes the second step of the riboflavin biosynthesis pathway [Source:SGD;Acc:S000000357]
B	YBR154C	RPB5	1586	-163.6	4	RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation [Source:SGD;Acc:S000000358]
B	YBR155W	CNS1	748	-222.8	4	TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion [Source:SGD;Acc:S000000359]
B	YBR156C	SLI15	182	-274.3	4	Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates kinetochore-microtubule attachments, activation of the spindle tension checkpoint, and mitotic spindle disassembly [Source:SGD;Acc:S000000360]
B	YBR157C	ICS2	197	-65.6	4	Protein of unknown function; null mutation does not confer any obvious defects in growth, spore germination, viability, or carbohydrate utilization [Source:SGD;Acc:S000000361]
B	YBR158W	AMN1	96	-44.8	4	Protein required for daughter cell separation, multiple mitotic checkpoints, and chromosome stability; contains 12 degenerate leucine-rich repeat motifs; expression is induced by the Mitotic Exit Network (MEN) [Source:SGD;Acc:S000000362]
B	YBR159W	IFA38	1421	-375.9	4	Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides [Source:SGD;Acc:S000000363]
B	YBR160W	CDC28	1439	-375.3	4	Catalytic subunit of the main cell cycle cyclin-dependent kinase (CDK); alternately associates with G1 cyclins (CLNs) and G2/M cyclins (CLBs) which direct the CDK to specific substrates [Source:SGD;Acc:S000000364]
B	YBR161W	CSH1	42	-21.8	4	Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p [Source:SGD;Acc:S000000365]
B	YBR162C	TOS1	1069	-200.3	4	Covalently-bound cell wall protein of unknown function; identified as a cell cycle regulated SBF target gene; deletion mutants are highly resistant to treatment with beta-1,3-glucanase; has sequence similarity to YJL171C [Source:SGD;Acc:S000000366]
B	YBR162W-A	YSY6	23	-10.1	4	Protein whose expression suppresses a secretory pathway mutation in E. coli; has similarity to the mammalian RAMP4 protein involved in secretion [Source:SGD;Acc:S000002158]
B	YBR163W	EXO5	61	-192.4	4	Mitochondrial 5'-3' exonuclease and sliding exonuclease, required for mitochondrial genome maintenance; distantly related to the RecB nuclease domain of bacterial RecBCD recombinases; may be regulated by the transcription factor Ace2 [Source:SGD;Acc:S000000367]
B	YBR164C	ARL1	980	-217.2	4	Soluble GTPase with a role in regulation of membrane traffic; regulates potassium influx; G protein of the Ras superfamily, similar to ADP-ribosylation factor [Source:SGD;Acc:S000000368]
B	YBR165W	UBS1	4	-5.6	2	Ubiquitin-conjugating enzyme suppressor that functions as a general positive regulator of Cdc34p activity; nuclear protein that may represent a link between nucleocytoplasmic transport and ubiquitin ligase activity [Source:SGD;Acc:S000000369]
B	YBR166C	TYR1	596	-267.6	4	Prephenate dehydrogenase involved in tyrosine biosynthesis, expression is dependent on phenylalanine levels [Source:SGD;Acc:S000000370]
B	YBR167C	POP7	84	-42.6	4	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs [Source:SGD;Acc:S000000371]
B	YBR168W	PEX32	23	-65.4	4	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p [Source:SGD;Acc:S000000372]
B	YBR169C	SSE2	3905	-958.4	4	Member of the heat shock protein 70 (HSP70) family; may be involved in protein folding; localized to the cytoplasm; highly homologous to the heat shock protein Sse1p [Source:SGD;Acc:S000000373]
B	YBR170C	NPL4	772	-435	4	Ubiquitin-binding protein involved in protein degradation; Cdc48p-Npl4p-Ufd1p complex participates in ER-associated degradation (ERAD) while Cdc48p-Npl4p-Vms1p complex participates in mitochondria-associated degradation (MAD) [Source:SGD;Acc:S000000374]
B	YBR171W	SEC66	497	-170.4	4	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER [Source:SGD;Acc:S000000375]
B	YBR172C	SMY2	1223	-489.5	4	Protein of unknown function involved in COPII vesicle formation; interacts with the Sec23p/Sec24p subcomplex; overexpression suppresses the temperature sensitivity of a myo2 mutant; has similarity to S. pombe Mpd2 [Source:SGD;Acc:S000000376]
B	YBR173C	UMP1	118	-78.7	4	Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly [Source:SGD;Acc:S000000377]
B	YBR174C	YBR174C	1	-1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YBR175W; null mutant is viable and sporulation defective [Source:SGD;Acc:S000000378]
B	YBR175W	SWD3	120	-123.5	4	Essential subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres; WD40 beta propeller superfamily member and ortholog of mammalian WDR5 [Source:SGD;Acc:S000000379]
B	YBR176W	ECM31	370	-115.5	4	Ketopantoate hydroxymethyltransferase, required for pantothenic acid biosynthesis, converts 2-oxoisovalerate into 2-dehydropantoate [Source:SGD;Acc:S000000380]
B	YBR177C	EHT1	1582	-966.8	4	Acyl-coenzymeA:ethanol O-acyltransferase that plays a minor role in medium-chain fatty acid ethyl ester biosynthesis; possesses short-chain esterase activity; localizes to lipid particles and the mitochondrial outer membrane [Source:SGD;Acc:S000000381]
B	YBR178W	YBR178W	1	-0.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR177C [Source:SGD;Acc:S000000382]
B	YBR179C	FZO1	386	-451.4	4	Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for dest  n by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system [Source:SGD;Acc:S000000383]
B	YBR180W	DTR1	14	-2.4	2	Putative dityrosine transporter, required for spore wall synthesis; expressed during sporulation; member of the major facilitator superfamily (DHA1 family) of multidrug resistance transporters [Source:SGD;Acc:S000000384]
B	YBR181C	RPS6B	4957	-768	4	Protein component of the small (40S) ribosomal subunit; identical to Rps6Ap and has similarity to rat S6 ribosomal protein [Source:SGD;Acc:S000000385]
B	YBR182C	SMP1	18	-24.2	2	Putative transcription factor involved in regulating the response to osmotic stress; member of the MADS-box family of transcription factors [Source:SGD;Acc:S000000386]
B	YBR182C-A	YBR182C-A	4	0	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028603]
B	YBR183W	YPC1	85	-55.1	4	Alkaline ceramidase that also has reverse (CoA-independent) ceramide synthase activity, catalyzes both breakdown and synthesis of phytoceramide; overexpression confers fumonisin B1 resistance [Source:SGD;Acc:S000000387]
B	YBR184W	YBR184W	29	-12.6	2	Putative protein of unknown function; YBR184W is not an essential gene [Source:SGD;Acc:S000000388]
B	YBR185C	MBA1	195	-92.5	4	Membrane-associated mitochondrial ribosome receptor; forms a complex with Mdm38p that may facilitate recruitment of mRNA-specific translational activators to ribosomes; possible role in protein export from the matrix to inner membrane [Source:SGD;Acc:S000000389]
B	YBR186W	PCH2	30	-13.6	2	Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA [Source:SGD;Acc:S000000390]
B	YBR187W	GDT1	286	-118.7	4	Putative protein of unknown function; expression is reduced in a gcr1 null mutant; GFP-fusion protein localizes to the vacuole; expression pattern and physical interactions suggest a possible role in ribosome biogenesis [Source:SGD;Acc:S000000391]
B	YBR188C	NTC20	221	-78	4	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs [Source:SGD;Acc:S000000392]
B	YBR189W	RPS9B	4344	-440.5	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Ap and has similarity to E. coli S4 and rat S9 ribosomal proteins [Source:SGD;Acc:S000000393]
B	YBR190W	YBR190W	6	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ribosomal protein gene RPL21A/YBR191W [Source:SGD;Acc:S000000394]
B	YBR191W	RPL21A	3991	-539.8	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Bp and has similarity to rat L21 ribosomal protein [Source:SGD;Acc:S000000395]
B	YBR191W-A	YBR191W-A	2	-2.8	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007594]
B	YBR192W	RIM2	326	-132	4	Mitochondrial pyrimidine nucleotide transporter; imports pyrimidine nucleoside triphosphates and exports pyrimidine nucleoside monophosphates; member of the mitochondrial carrier family [Source:SGD;Acc:S000000396]
B	YBR193C	MED8	263	-163.6	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation [Source:SGD;Acc:S000000397]
B	YBR194W	AIM4	70	-25.8	4	Protein proposed to be associated with the nuclear pore complex; null mutant is viable, displays elevated frequency of mitochondrial genome loss and is sensitive to freeze-thaw stress [Source:SGD;Acc:S000000398]
B	YBR195C	MSI1	226	-137.7	4	Subunit of chromatin assembly factor I (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the DNA damage checkp  fter DNA repair; and chromatin dynamics during transcription; Msi1p localizes to both nucleus and cytoplasm and has an independent role as a negative regulator of the RAS/cAMP pathway via sequestration of Npr1p kinase [Source:SGD;Acc:S000000399]
B	YBR196C	PGI1	4375	-2975.4	4	Glycolytic enzyme phosphoglucose isomerase, catalyzes the interconversion of glucose-6-phosphate and fructose-6-phosphate; required for cell cycle progression and completion of the gluconeogenic events of sporulation [Source:SGD;Acc:S000000400]
B	YBR196C-A	YBR196C-A	1	-2	2	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028534]
B	YBR196C-B	YBR196C-B	5	-5.9	2	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028816]
B	YBR197C	YBR197C	218	-93	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR197C is not an essential gene [Source:SGD;Acc:S000000401]
B	YBR198C	TAF5	1448	-3029.6	4	Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification [Source:SGD;Acc:S000000402]
B	YBR199W	KTR4	751	-422.8	4	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family [Source:SGD;Acc:S000000403]
B	YBR200W	BEM1	636	-221.5	4	Protein containing SH3-domains, involved in establishing cell polarity and morphogenesis; functions as a scaffold protein for complexes that include Cdc24p, Ste5p, Ste20p, and Rsr1p [Source:SGD;Acc:S000000404]
B	YBR200W-A	YBR200W-A	2	-1.2	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028535]
B	YBR201C-A	YBR201C-A	2	-13.9	2	Putative protein of unknown function [Source:SGD;Acc:S000087085]
B	YBR201W	DER1	33	-27.9	4	Endoplasmic reticulum membrane protein, required for ER-associated protein degradation of misfolded or unassembled proteins; N- and C- termini protrude into the cytoplasm, has similarity to Dfm1p [Source:SGD;Acc:S000000405]
B	YBR202W	MCM7	800	-1269.3	4	Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex [Source:SGD;Acc:S000000406]
B	YBR203W	COS111	41	-242.2	4	Protein required for resistance to the antifungal drug ciclopirox olamine; not related to the subtelomerically-encoded COS family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000407]
B	YBR204C	LDH1	260	-232.3	4	Serine hydrolase; exhibits active esterase plus weak triacylglycerol lipase activities; proposed role in lipid homeostasis, regulating phospholipid and non-polar lipid levels and required for mobilization of LD-stored lipids; localizes to the lipid   t (LD) surface; contains a classical serine containing catalytic triad (GxSxG motif) [Source:SGD;Acc:S000000408]
B	YBR205W	KTR3	1003	-403.2	4	Putative alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family; Svp26p mediates uptake of Ktr3p into COPII vesicles [Source:SGD;Acc:S000000409]
B	YBR206W	YBR206W	2	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KTR3 [Source:SGD;Acc:S000000410]
B	YBR207W	FTH1	307	-112.8	4	Putative high affinity iron transporter involved in transport of intravacuolar stores of iron; forms complex with Fet5p; expression is regulated by iron; proposed to play indirect role in endocytosis [Source:SGD;Acc:S000000411]
B	YBR208C	DUR1,2	1281	-986.2	4	DUR1,2, Urea amidolyase, contains both urea carboxylase and allophanate hydrolase activities, degrades urea to CO2 and NH3; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation [Source:SGD;Acc:S000000412]
B	YBR209W	YBR209W	2	-12	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR209W is not an essential gene [Source:SGD;Acc:S000000413]
B	YBR210W	ERV15	69	-21.5	4	Protein involved in export of proteins from the endoplasmic reticulum, has similarity to Erv14p [Source:SGD;Acc:S000000414]
B	YBR211C	AME1	191	-128.2	4	Essential kinetochore protein associated with microtubules and spindle pole bodies; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance [Source:SGD;Acc:S000000415]
B	YBR212W	NGR1	855	-234	4	RNA binding protein that negatively regulates growth rate; interacts with the 3' UTR of the mitochondrial porin (POR1) mRNA and enhances its degradation; overexpression impairs mitochondrial function; interacts with Dhh1p to mediate POR1 mRNA decay;  ssed in stationary phase [Source:SGD;Acc:S000000416]
B	YBR213W	MET8	207	-104.4	4	Bifunctional dehydrogenase and ferrochelatase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis [Source:SGD;Acc:S000000417]
B	YBR214W	SDS24	1341	-477.2	4	One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding; may play an indirect role in fluid-phase endocytosis [Source:SGD;Acc:S000000418]
B	YBR215W	HPC2	594	-180.3	4	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; mutants display synthetic defects with subunits of FACT, a complex that allows passage of RNA Pol II through nucleosomes [Source:SGD;Acc:S000000419]
B	YBR216C	YBP1	366	-391.9	4	Protein required for oxidation of specific cysteine residues of the transcription factor Yap1p, resulting in the nuclear localization of Yap1p in response to stress [Source:SGD;Acc:S000000420]
B	YBR217W	ATG12	13	-18.8	4	Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation [Source:SGD;Acc:S000000421]
B	YBR218C	PYC2	3457	-1924	4	Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc1p but differentially regulated; mutations in the human homolog are associated with lactic acidosis [Source:SGD;Acc:S000000422]
B	YBR219C	YBR219C	15	-7.9	4	Putative protein of unknown function; YBR219C is not an essential gene [Source:SGD;Acc:S000000423]
B	YBR220C	YBR220C	109	-143.9	4	Putative protein of unknown function; YBR220C is not an essential gene [Source:SGD;Acc:S000000424]
B	YBR221C	PDB1	2921	-1475.3	4	E1 beta subunit of the pyruvate dehydrogenase (PDH) complex, which is an evolutionarily-conserved multi-protein complex found in mitochondria [Source:SGD;Acc:S000000425]
B	YBR221W-A	YBR221W-A	2	-1.3	1	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028817]
B	YBR222C	PCS60	1346	-759	4	Peroxisomal protein that binds AMP and mRNA, localizes to both the peroxisomal peripheral membrane and matrix, expression is highly inducible by oleic acid, similar to E. coli long chain acyl-CoA synthetase [Source:SGD;Acc:S000000426]
B	YBR223C	TDP1	75	-96.1	4	Tyrosyl-DNA Phosphodiesterase I, hydrolyzes 3' and 5'-phosphotyrosyl bonds, involved in the repair of DNA lesions created by topoisomerase I and topoisomerase II; mutations in human homolog result in the neurodegenerative disease SCANI [Source:SGD;Acc:S000000427]
B	YBR223W-A	YBR223W-A	0	nf	1	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps YBR223C; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028604]
B	YBR224W	YBR224W	3	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TDP1 [Source:SGD;Acc:S000000428]
B	YBR225W	YBR225W	518	-404.6	4	Putative protein of unknown function; non-essential gene identified in a screen for mutants affected in mannosylphophorylation of cell wall components [Source:SGD;Acc:S000000429]
B	YBR226C	YBR226C	4	-2.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YBR225W [Source:SGD;Acc:S000000430]
B	YBR227C	MCX1	700	-249.6	4	Mitochondrial matrix protein; putative ATP-binding chaperone with non-proteolytic function; similar to bacterial ClpX proteins [Source:SGD;Acc:S000000431]
B	YBR228W	SLX1	8	-39	2	Subunit of a complex, with Slx4p, that hydrolyzes 5' branches from duplex DNA in response to stalled or converging replication forks; function overlaps with that of Sgs1p-Top3p [Source:SGD;Acc:S000000432]
B	YBR229C	ROT2	689	-456	4	Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations [Source:SGD;Acc:S000000433]
B	YBR230C	OM14	600	-206.2	4	Integral mitochondrial outer membrane protein; abundance is decreased in cells grown in glucose relative to other carbon sources; appears to contain 3 alpha-helical transmembrane segments; ORF encodes a 97-basepair intron [Source:SGD;Acc:S000000434]
B	YBR230W-A	YBR230W-A	54	-33.9	4	Putative protein of unknown function [Source:SGD;Acc:S000029722]
B	YBR231C	SWC5	216	-442.4	4	Protein of unknown function, component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A [Source:SGD;Acc:S000000435]
B	YBR232C	YBR232C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000436]
B	YBR233W	PBP2	465	-100.7	4	RNA binding protein with similarity to mammalian heterogeneous nuclear RNP K protein, involved in the regulation of telomere position effect and telomere length [Source:SGD;Acc:S000000437]
B	YBR233W-A	DAD3	298	-69.5	4	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis [Source:SGD;Acc:S000007595]
B	YBR234C	ARC40	1383	-373.2	4	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches [Source:SGD;Acc:S000000438]
B	YBR235W	VHC1	230	-101.4	4	Putative ion transporter, similar to mammalian electroneutral Na(+)-(K+)-C1- cotransporter family; YBR235W is not an essential gene [Source:SGD;Acc:S000000439]
B	YBR236C	ABD1	514	-218.8	4	Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA [Source:SGD;Acc:S000000440]
B	YBR237W	PRP5	174	-193.5	4	RNA helicase in the DEAD-box family, necessary for prespliceosome formation, bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA [Source:SGD;Acc:S000000441]
B	YBR238C	YBR238C	285	-281.1	4	Mitochondrial membrane protein with similarity to Rmd9p; not required for respiratory growth but causes a synthetic respiratory defect in combination with rmd9 mutations; transcriptionally up-regulated by TOR; deletion increases life span [Source:SGD;Acc:S000000442]
B	YBR239C	ERT1	75	-49.4	4	Transcriptional regulator of nonfermentable carbon utilization; GFP-fusion protein localizes to cytoplasm, nucleus; null mutation affects periodicity of transcriptional and metabolic oscillation; plays role in restricting Ty1 transposition [Source:SGD;Acc:S000000443]
B	YBR240C	THI2	8	-6.6	2	Transcriptional activator of thiamine biosynthetic genes; interacts with regulatory factor Thi3p to control expression of thiamine biosynthetic genes with respect to thiamine availability; acts together with Pdc2p to respond to thiaminediphosphate d   possibly as related to carbon source availability; zinc finger protein of the Zn(II)2Cys6 type [Source:SGD;Acc:S000000444]
B	YBR241C	YBR241C	143	-113	4	Putative transporter, member of the sugar porter family; green fluorescent protein (GFP)-fusion protein localizes to the vacuolar membrane; YBR241C is not an essential gene [Source:SGD;Acc:S000000445]
B	YBR242W	YBR242W	249	-135.4	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YBR242W is not an essential gene [Source:SGD;Acc:S000000446]
B	YBR243C	ALG7	45	-20.1	4	UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin [Source:SGD;Acc:S000000447]
B	YBR244W	GPX2	1454	-217.6	4	Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress [Source:SGD;Acc:S000000448]
B	YBR245C	ISW1	1618	-749.8	4	Member of the imitation-switch (ISWI) class of ATP-dependent chromatin remodeling complexes; ATPase that forms a complex with Ioc2p and Ioc4p to regulate transcription elongation, and a complex with Ioc3p to repress transcription initiation [Source:SGD;Acc:S000000449]
B	YBR246W	RRT2	233	-257	4	WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with   sed levels of rDNA transcription; null mutants display a weak carboxypeptidase Y missorting/secretion phenotype; human ortholog is WDR85 [Source:SGD;Acc:S000000450]
B	YBR247C	ENP1	1387	-298.8	4	Protein associated with U3 and U14 snoRNAs, required for pre-rRNA processing and 40S ribosomal subunit synthesis; localized in the nucleus and concentrated in the nucleolus [Source:SGD;Acc:S000000451]
B	YBR248C	HIS7	1965	-748.5	4	Imidazole glycerol phosphate synthase (glutamine amidotransferase:cyclase), catalyzes the fifth and sixth steps of histidine biosynthesis and also produces 5-aminoimidazole-4-carboxamide ribotide (AICAR), a purine precursor [Source:SGD;Acc:S000000452]
B	YBR249C	ARO4	3244	-654.2	4	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan [Source:SGD;Acc:S000000453]
B	YBR250W	SPO23	21	-12.3	2	Protein of unknown function; associates with meiosis-specific protein Spo1p [Source:SGD;Acc:S000000454]
B	YBR251W	MRPS5	459	-155.5	4	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000000455]
B	YBR252W	DUT1	823	-141	4	deoxyuridine triphosphate diphosphatase (dUTPase); catalyzes hydrolysis of dUTP to dUMP and PPi, thereby preventing incorporation of uracil into DNA during replication; critical for the maintenance of genetic stability; also has diphosphatase activi  deoxyinosine triphosphate [Source:SGD;Acc:S000000456]
B	YBR253W	SRB6	189	-58.4	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation [Source:SGD;Acc:S000000457]
B	YBR254C	TRS20	98	-50	4	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; mutations in the human homolog cause the spondyloepiphyseal dysplasia tarda (SEDL) disorder [Source:SGD;Acc:S000000458]
B	YBR255C-A	YBR255C-A	138	-55.5	4	Putative protein of unknown function; may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase); identified by sequence comparison with hemiascomycetous yeast species [Source:SGD;Acc:S000007649]
B	YBR255W	MTC4	290	-200.2	4	Protein of unknown function, required for normal growth rate at 15 degrees C; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; mtc4 is synthetically sick with cdc13-1 [Source:SGD;Acc:S000000459]
B	YBR256C	RIB5	965	-274.2	4	Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway [Source:SGD;Acc:S000000460]
B	YBR257W	POP4	88	-92.5	4	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P [Source:SGD;Acc:S000000461]
B	YBR258C	SHG1	157	-71	4	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lysine 4 and is required in transcriptional silencing near telomeres [Source:SGD;Acc:S000000462]
B	YBR259W	YBR259W	38	-15.7	2	Putative protein of unknown function; YBR259W is not an essential gene [Source:SGD;Acc:S000000463]
B	YBR260C	RGD1	550	-433	4	GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization [Source:SGD;Acc:S000000464]
B	YBR261C	TAE1	679	-137.6	4	AdoMet-dependent proline methyltransferase; catalyzes the dimethylation of ribosomal proteins Rpl12 and Rps25 at N-terminal proline residues; has a role in protein synthesis; fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000000465]
B	YBR262C	MIC12	355	-125.8	4	Mitochondrial inner membrane protein; subunit of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of cris  ctions and inner membrane architecture [Source:SGD;Acc:S000000466]
B	YBR263W	SHM1	2849	-858.1	4	Mitochondrial serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis; reverse reaction generates serine [Source:SGD;Acc:S000000467]
B	YBR264C	YPT10	394	-178.5	4	Rab family GTP-binding protein that contains the PEST signal sequence specific for proteolytic enzymes; may be involved in vesicular transport; overexpression leads to accumulation of Golgi-like cisternae with budding vesicles [Source:SGD;Acc:S000000468]
B	YBR265W	TSC10	474	-154.8	4	3-ketosphinganine reductase, catalyzes the second step in phytosphingosine synthesis, essential for growth in the absence of exogenous dihydrosphingosine or phytosphingosine, member of short chain dehydrogenase/reductase protein family [Source:SGD;Acc:S000000469]
B	YBR266C	SLM6	0	nf	1	Protein with a potential role in actin cytoskeleton organization; gene exhibits synthetic genetic interaction with MSS4 encoding phosphatidylinositol 4-phosphate kinase [Source:SGD;Acc:S000000470]
B	YBR267W	REI1	642	-181.7	4	Cytoplasmic pre-60S factor; required for the correct recycling of shuttling factors Alb1, Arx1 and Tif6 at the end of the ribosomal large subunit biogenesis; involved in bud growth in the mitotic signaling network [Source:SGD;Acc:S000000471]
B	YBR268W	MRPL37	239	-79.2	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000000472]
B	YBR269C	SDH8	480	-155.6	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000473]
B	YBR270C	BIT2	38	-82.1	3	Subunit of TORC2, a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; interacts with Slm1p and Slm2p, homologous PH domain-containing TORC2 substrates; similar to Bit61p [Source:SGD;Acc:S000000474]
B	YBR271W	EFM2	116	-162.6	4	S-adenosylmethionine-dependent methyltransferase; belongs to the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000000475]
B	YBR272C	HSM3	317	-177.2	4	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); involved in DNA mismatch repair during slow growth; weak similarity to Msh1p; related to human 19S subunit S5b [Source:SGD;Acc:S000000476]
B	YBR273C	UBX7	709	-236.5	4	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p [Source:SGD;Acc:S000000477]
B	YBR274W	CHK1	225	-1392	4	Serine/threonine kinase and DNA damage checkpoint effector, mediates cell cycle arrest via phosphorylation of Pds1p; phosphorylated by checkpoint signal transducer Mec1p; homolog of S. pombe and mammalian Chk1 checkpoint kinase [Source:SGD;Acc:S000000478]
B	YBR275C	RIF1	460	-372.8	4	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif2p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation [Source:SGD;Acc:S000000479]
B	YBR276C	PPS1	138	-253.9	4	Protein phosphatase with specificity for serine, threonine, and tyrosine residues; has a role in the DNA synthesis phase of the cell cycle [Source:SGD;Acc:S000000480]
B	YBR277C	YBR277C	1	0	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR278W [Source:SGD;Acc:S000000481]
B	YBR278W	DPB3	196	-47.5	4	Third-largest subunit of DNA polymerase II (DNA polymerase epsilon), required to maintain fidelity of chromosomal replication and also for inheritance of telomeric silencing; mRNA abundance peaks at the G1/S boundary of the cell cycle [Source:SGD;Acc:S000000482]
B	YBR279W	PAF1	1217	-611.7	4	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cell cycle-regulated genes; involved in SER3 repression by   g to maintain SRG1 transcription-dependent nucleosome occupancy; homolog of human PD2/hPAF1 [Source:SGD;Acc:S000000483]
B	YBR280C	SAF1	308	-289.2	4	F-Box protein involved in proteasome-dependent degradation of Aah1p during entry of cells into quiescence; interacts with Skp1 [Source:SGD;Acc:S000000484]
B	YBR281C	DUG2	633	-300.1	4	Probable di- and tri-peptidase; forms a complex with Dug1p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) [Source:SGD;Acc:S000000485]
B	YBR282W	MRPL27	332	-80.6	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000000486]
B	YBR283C	SSH1	1616	-320	4	Subunit of the Ssh1 translocon complex; Sec61p homolog involved in co-translational pathway of protein translocation; not essential [Source:SGD;Acc:S000000487]
B	YBR284W	YBR284W	17	-10.1	2	Putative protein of unknown function; YBR284W is not an essential gene; null mutant exhibits decreased resistance to rapamycin and wortmannin and synthetic phenotype with alpha-synuclein [Source:SGD;Acc:S000000488]
B	YBR285W	YBR285W	82	-26.6	4	Putative protein of unknown function; YBR285W is not an essential gene [Source:SGD;Acc:S000000489]
B	YBR286W	APE3	2538	-749.4	4	Vacuolar aminopeptidase Y, processed to mature form by Prb1p [Source:SGD;Acc:S000000490]
B	YBR287W	YBR287W	566	-94.8	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the ER; YBR287W is not an essential gene [Source:SGD;Acc:S000000491]
B	YBR288C	APM3	765	-271.4	4	Mu3-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway [Source:SGD;Acc:S000000492]
B	YBR289W	SNF5	550	-190.3	4	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf6p [Source:SGD;Acc:S000000493]
B	YBR290W	BSD2	99	-52.6	4	Heavy metal ion homeostasis protein, facilitates trafficking of Smf1p and Smf2p metal transporters to the vacuole where they are degraded, controls metal ion transport, prevents metal hyperaccumulation, functions in copper detoxification [Source:SGD;Acc:S000000494]
B	YBR291C	CTP1	386	-77.4	4	Mitochondrial inner membrane citrate transporter, member of the mitochondrial carrier family [Source:SGD;Acc:S000000495]
B	YBR292C	YBR292C	1	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YBR292C is not an essential gene [Source:SGD;Acc:S000000496]
B	YBR293W	VBA2	8	-10.6	2	Permease of basic amino acids in the vacuolar membrane [Source:SGD;Acc:S000000497]
B	YBR294W	SUL1	64	-70.3	2	High affinity sulfate permease of the SulP anion transporter family; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates [Source:SGD;Acc:S000000498]
B	YBR295W	PCA1	42	-21.1	2	Cadmium transporting P-type ATPase; may also have a role in copper and iron homeostasis; stabilized by Cd binding, which prevents ubiquitination; S288C and other lab strains contain a G970R mutation which eliminates Cd transport function [Source:SGD;Acc:S000000499]
B	YBR296C	PHO89	74	-26.7	4	Na+/Pi cotransporter, active in early growth phase; similar to phosphate transporters of Neurospora crassa; transcription regulated by inorganic phosphate concentrations and Pho4p [Source:SGD;Acc:S000000500]
B	YBR296C-A	YBR296C-A	0	nf	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028605]
B	YBR297W	MAL33	20	-79.3	4	MAL-activator protein, part of complex locus MAL3; nonfunctional in genomic reference strain S288C [Source:SGD;Acc:S000000501]
B	YBR298C	MAL31	37	-18.7	2	Maltose permease, high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL3 complex locus; member of the 12 transmembrane domain superfamily of sugar transporters; functional in genomic reference strain S288C [Source:SGD;Acc:S000000502]
B	YBR298C-A	YBR298C-A	8	-2.1	2	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028606]
B	YBR299W	MAL32	213	-268.4	4	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL3 complex locus; functional in genomic reference strain S288C; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose [Source:SGD;Acc:S000000503]
B	YBR300C	YBR300C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YBR301W; YBR300C is not an essential gene [Source:SGD;Acc:S000000504]
B	YBR301W	PAU24	2	-1.1	1	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth [Source:SGD;Acc:S000000505]
B	YBR302C	COS2	226	-76.9	4	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000000506]
C	YCL001W	RER1	387	-95.1	4	Protein involved in retention of membrane proteins, including Sec12p, in the ER; localized to Golgi; functions as a retrieval receptor in returning membrane proteins to the ER [Source:SGD;Acc:S000000507]
C	YCL001W-A	YCL001W-A	2	-0.1	1	Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III [Source:SGD;Acc:S000007221]
C	YCL001W-B	YCL001W-B	0	nf	1	Putative protein of unknown function; YCL001W-B gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III [Source:SGD;Acc:S000007596]
C	YCL002C	YCL002C	7	-2.2	2	Putative protein of unknown function; YCL002C is not an essential gene [Source:SGD;Acc:S000000508]
C	YCL004W	PGS1	66	-233.4	4	Phosphatidylglycerolphosphate synthase, catalyzes the synthesis of phosphatidylglycerolphosphate from CDP-diacylglycerol and sn-glycerol 3-phosphate in the first committed and rate-limiting step of cardiolipin biosynthesis [Source:SGD;Acc:S000000510]
C	YCL005W	LDB16	120	-43.8	4	Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria [Source:SGD;Acc:S000000511]
C	YCL005W-A	VMA9	48	-43.5	2	Vacuolar H+ ATPase subunit e of the V-ATPase V0 subcomplex; essential for vacuolar acidification; interacts with the V-ATPase assembly factor Vma21p in the ER; involved in V0 biogenesis [Source:SGD;Acc:S000028508]
C	YCL007C	YCL007C	0	nf	1	Dubious ORF unlikely to encode a protein; overlaps verified ORF YCL005W-A; mutations in YCL007C were thought to confer sensitivity to calcofluor white, but this phenotype was later shown to be due to the defect in YCL005W-A [Source:SGD;Acc:S000000513]
C	YCL008C	STP22	144	-98.8	4	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype [Source:SGD;Acc:S000000514]
C	YCL009C	ILV6	2758	-590.5	4	Regulatory subunit of acetolactate synthase, which catalyzes the first step of branched-chain amino acid biosynthesis; enhances activity of the Ilv2p catalytic subunit, localizes to mitochondria [Source:SGD;Acc:S000000515]
C	YCL010C	SGF29	478	-306.6	4	Component of the HAT/Core module of the SAGA, SLIK, and ADA complexes; HAT/Core module also contains Gcn5p, Ngg1p, and Ada2p; binds methylated histone H3K4; involved in transcriptional regulation through SAGA recruitment to target promoters and H3 a  tion [Source:SGD;Acc:S000000516]
C	YCL011C	GBP2	1448	-322.6	4	Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Hrb1p and Npl3p; also binds single-stranded telomeric repeat sequence in vitro [Source:SGD;Acc:S000000517]
C	YCL012C	YCL012C	445	-112.4	4	Putative protein of unknown function; orthologs are present in S. bayanus, S. paradoxus and Ashbya gossypii; YCL012C is not an essential gene [Source:SGD;Acc:S000029705]
C	YCL014W	BUD3	1127	-590.2	4	Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding [Source:SGD;Acc:S000000520]
C	YCL016C	DCC1	229	-118.3	4	Subunit of a complex with Ctf8p and Ctf18p that shares some components with Replication Factor C, required for sister chromatid cohesion and telomere length maintenance [Source:SGD;Acc:S000000521]
C	YCL017C	NFS1	1270	-586.7	4	Cysteine desulfurase involved in iron-sulfur cluster (Fe/S) biogenesis and in thio-modification of mitochondrial and cytoplasmic tRNAs; essential protein located predominantly in mitochondria [Source:SGD;Acc:S000000522]
C	YCL018W	LEU2	944	-777.6	4	Beta-isopropylmalate dehydrogenase (IMDH), catalyzes the third step in the leucine biosynthesis pathway [Source:SGD;Acc:S000000523]
C	YCL019W	YCL019W	2420	-811.5	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000000524]
C	YCL020W	YCL020W	1069	-427.5	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000000525]
C	YCL021W-A	YCL021W-A	7	-2.1	2	Putative protein of unknown function [Source:SGD;Acc:S000007549]
C	YCL022C	YCL022C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene KCC4/YCL024W [Source:SGD;Acc:S000000527]
C	YCL023C	YCL023C	2	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF KCC4 [Source:SGD;Acc:S000000528]
C	YCL024W	KCC4	399	-1853.3	4	Protein kinase of the bud neck involved in the septin checkpoint, associates with septin proteins, negatively regulates Swe1p by phosphorylation, shows structural homology to bud neck kinases Gin4p and Hsl1p [Source:SGD;Acc:S000000529]
C	YCL025C	AGP1	544	-173.7	4	Low-affinity amino acid permease with broad substrate range, involved in uptake of asparagine, glutamine, and other amino acids; expression is regulated by the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p) [Source:SGD;Acc:S000000530]
C	YCL026C-A	FRM2	55	-521.2	4	Protein of unknown function, involved in the integration of lipid signaling pathways with cellular homeostasis; expression induced in cells treated with the mycotoxin patulin; has similarity to bacterial nitroreductases [Source:SGD;Acc:S000000589]
C	YCL026C-B	HBN1	492	-159.5	4	Putative protein of unknown function; similar to bacterial nitroreductases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein becomes insoluble upon intracellular iron depletion [Source:SGD;Acc:S000007548]
C	YCL027W	FUS1	77	-30.8	4	Membrane protein localized to the shmoo tip, required for cell fusion; expression regulated by mating pheromone; proposed to coordinate signaling, fusion, and polarization events required for fusion; potential Cdc28p substrate [Source:SGD;Acc:S000000532]
C	YCL028W	RNQ1	1752	-827.6	4	[PIN(+)] prion, an infectious protein conformation that is generally an ordered protein aggregate [Source:SGD;Acc:S000000533]
C	YCL029C	BIK1	354	-171.2	4	Microtubule-associated protein, component of the interface between microtubules and kinetochore, involved in sister chromatid separation; essential in polyploid cells but not in haploid or diploid cells; ortholog of mammalian CLIP-170 [Source:SGD;Acc:S000000534]
C	YCL030C	HIS4	3083	-1323.2	4	Multifunctional enzyme containing phosphoribosyl-ATP pyrophosphatase, phosphoribosyl-AMP cyclohydrolase, and histidinol dehydrogenase activities; catalyzes the second, third, ninth and tenth steps in histidine biosynthesis [Source:SGD;Acc:S000000535]
C	YCL031C	RRP7	549	-176	4	Essential protein involved in rRNA processing and ribosome biogenesis [Source:SGD;Acc:S000000536]
C	YCL032W	STE50	298	-83.6	4	Protein involved in mating response, invasive/filamentous growth, and osmotolerance, acts as an adaptor that links G protein-associated Cdc42p-Ste20p complex to the effector Ste11p to modulate signal transduction [Source:SGD;Acc:S000000537]
C	YCL033C	MXR2	389	-107.5	4	Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan [Source:SGD;Acc:S000000538]
C	YCL034W	LSB5	926	-199.1	4	Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat [Source:SGD;Acc:S000000539]
C	YCL035C	GRX1	1677	-184.7	4	Hydroperoxide and superoxide-radical responsive heat-stable glutathione-dependent disulfide oxidoreductase with active site cysteine pair; protects cells from oxidative damage [Source:SGD;Acc:S000000540]
C	YCL036W	GFD2	52	-34.8	3	Protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation [Source:SGD;Acc:S000000541]
C	YCL037C	SRO9	3387	-1106.9	4	Cytoplasmic RNA-binding protein that associates with translating ribosomes; involved in heme regulation of Hap1p as a component of the HMC complex, also involved in the organization of actin filaments; contains a La motif [Source:SGD;Acc:S000000542]
C	YCL038C	ATG22	103	-114.6	4	Vacuolar integral membrane protein required for efflux of amino acids during autophagic body breakdown in the vacuole; null mutation causes a gradual loss of viability during starvation [Source:SGD;Acc:S000000543]
C	YCL039W	GID7	360	-977.2	4	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains six WD40 repeats; computational analysis suggests that Gid7p and Moh1p have similar functions [Source:SGD;Acc:S000000544]
C	YCL040W	GLK1	3090	-1615.4	4	Glucokinase, catalyzes the phosphorylation of glucose at C6 in the first irreversible step of glucose metabolism; one of three glucose phosphorylating enzymes; expression regulated by non-fermentable carbon sources [Source:SGD;Acc:S000000545]
C	YCL041C	YCL041C	1	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps both the verified gene PDI1/YCL043C and the uncharacterized gene YCL042W [Source:SGD;Acc:S000000546]
C	YCL042W	YCL042W	72	-13	2	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm [Source:SGD;Acc:S000000547]
C	YCL043C	PDI1	3799	-1193.7	4	Protein disulfide isomerase; multifunctional protein resident in the endoplasmic reticulum lumen, essential for the formation of disulfide bonds in secretory and cell-surface proteins, unscrambles non-native disulfide bonds; forms a complex with Mnl  t has exomannosidase activity, processing unfolded protein-bound Man8GlcNAc2 oligosaccharides to Man7GlcNAc2 which promotes degradation in the unfolded protein response [Source:SGD;Acc:S000000548]
C	YCL044C	MGR1	515	-302.8	4	Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr3p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA [Source:SGD;Acc:S000000549]
C	YCL045C	EMC1	972	-528.7	4	Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; interacts with Gal80p [Source:SGD;Acc:S000000550]
C	YCL046W	YCL046W	6	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YCL045C [Source:SGD;Acc:S000000551]
C	YCL047C	POF1	271	-102.6	4	Protein involved in the filamentation pathway; interacts physically with Kss1p and suppresses the filamentation defect of a kss1 deletion [Source:SGD;Acc:S000000552]
C	YCL048W	SPS22	23	-4.6	2	Protein of unknown function, redundant with Sps2p for the organization of the beta-glucan layer of the spore wall [Source:SGD;Acc:S000000553]
C	YCL048W-A	YCL048W-A	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000087203]
C	YCL049C	YCL049C	34	-30.9	4	Protein of unknown function; localizes to membrane fraction; YCL049C is not an essential gene [Source:SGD;Acc:S000000554]
C	YCL050C	APA1	2750	-798.6	4	Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase I (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa2p [Source:SGD;Acc:S000000555]
C	YCL051W	LRE1	251	-113.4	4	Protein involved in control of cell wall structure and stress response; overproduction confers resistance to cell-wall degrading enzymes; exhibits genetic interactions with genes involved in the cell wall integrity pathway [Source:SGD;Acc:S000000556]
C	YCL052C	PBN1	270	-231.3	4	Essential component of glycosylphosphatidylinositol-mannosyltransferase I, required for the autocatalytic post-translational processing of the protease B precursor Prb1p, localizes to ER in lumenal orientation; homolog of mammalian PIG-X [Source:SGD;Acc:S000000557]
C	YCL054W	SPB1	1195	-441.3	4	AdoMet-dependent methyltransferase involved in rRNA processing and 60S ribosomal subunit maturation; methylates G2922 in the tRNA docking site of the large subunit rRNA and in the absence of snR52, U2921; suppressor of PAB1 mutants [Source:SGD;Acc:S000000559]
C	YCL055W	KAR4	77	-52.5	4	Transcription factor required for gene regulation in response to pheromones; also required during meiosis; exists in two forms, a slower-migrating form more abundant during vegetative growth and a faster-migrating form induced by pheromone [Source:SGD;Acc:S000000560]
C	YCL056C	PEX34	16	-14.8	2	Peroxisomal integral membrane protein that regulates peroxisome populations; interacts with Pex11p, Pex25p, and Pex27p to control both constitutive peroxisome division and peroxisome morphology and abundance during peroxisome proliferation [Source:SGD;Acc:S000000561]
C	YCL057C-A	MIC10	1115	-141.7	4	Mitochondrial protein essential for proper inner membrane organization; conserved component of the mitochondrial inner membrane organizing system (MICOS, MINOS, or MitOS), a scaffold-like structure on the intermembrane space side of the inner membra  ch has a role in the maintenance of crista junctions and inner membrane architecture; ortholog of human MINOS1 [Source:SGD;Acc:S000007547]
C	YCL057W	PRD1	1696	-578	4	Zinc metalloendopeptidase, found in the cytoplasm and intermembrane space of mitochondria; with Cym1p, involved in degradation of mitochondrial proteins and of presequence peptides cleaved from imported proteins [Source:SGD;Acc:S000000562]
C	YCL058C	FYV5	3	0	1	Protein involved in regulation of the mating pathway; binds with Matalpha2p to promoters of haploid-specific genes; required for survival upon exposure to K1 killer toxin; involved in ion homeostasis [Source:SGD;Acc:S000000563]
C	YCL058W-A	ADF1	74	-22.4	3	Transcriptional repressor encoded by the antisense strand of the FYV5 gene; negatively regulates transcription of FYV5 by binding to the promoter on the sense strand [Source:SGD;Acc:S000028518]
C	YCL059C	KRR1	1215	-313.2	4	Essential nucleolar protein required for the synthesis of 18S rRNA and for the assembly of 40S ribosomal subunit [Source:SGD;Acc:S000000564]
C	YCL061C	MRC1	551	-284.6	4	S-phase checkpoint protein required for DNA replication; interacts with and stabilizes Pol2p at stalled replication forks during stress, where it forms a pausing complex with Tof1p and is phosphorylated by Mec1p; protects uncapped telomeres [Source:SGD;Acc:S000000566]
C	YCL063W	VAC17	46	-18.1	4	Phosphoprotein involved in vacuole inheritance; degraded in late M phase of the cell cycle; acts as a vacuole-specific receptor for myosin Myo2p [Source:SGD;Acc:S000000568]
C	YCL064C	CHA1	1132	-282.4	4	Catabolic L-serine (L-threonine) deaminase, catalyzes the degradation of both L-serine and L-threonine; required to use serine or threonine as the sole nitrogen source, transcriptionally induced by serine and threonine [Source:SGD;Acc:S000000569]
C	YCL065W	YCL065W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps HMLALPHA1 [Source:SGD;Acc:S000000570]
C	YCL066W	HMLALPHA1	3	-1.2	1	Silenced copy of ALPHA1 at HML, encoding a transcriptional coactivator involved in the regulation of mating-type alpha-specific gene expression [Source:SGD;Acc:S000000571]
C	YCL067C	HMLALPHA2	74	-93.4	4	Silenced copy of ALPHA2 at HML; homeobox-domain protein that associates with Mcm1p in haploid cells to repress a-specific gene expression and interacts with a1p in diploid cells to repress haploid-specific gene expression [Source:SGD;Acc:S000000572]
C	YCL068C	YCL068C	7	-12.7	2	Putative protein of unknown function [Source:SGD;Acc:S000000573]
C	YCL069W	VBA3	20	-23.7	2	Permease of basic amino acids in the vacuolar membrane [Source:SGD;Acc:S000000574]
C	YCL073C	GEX1	10	-3.6	2	Proton:glutathione antiporter localized to the vacuolar and plasma membranes; imports glutathione from the vacuole and exports it through the plasma membrane; has a role in resistance to oxidative stress and modulation of the PKA pathway [Source:SGD;Acc:S000000575]
C	YCL076W	YCL076W	3	-5.6	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000581]
C	YCR001W	YCR001W	5	-2.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR001W is not an essential gene [Source:SGD;Acc:S000000594]
C	YCR002C	CDC10	1872	-1261.7	4	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds f  ruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; N-terminus contributes septin interaction with phosphatidylinositol-4,5-bisphosphate [Source:SGD;Acc:S000000595]
C	YCR003W	MRPL32	201	-55.7	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000000596]
C	YCR004C	YCP4	1944	-396.3	4	Protein of unknown function, has sequence and structural similarity to flavodoxins; predicted to be palmitoylated; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000597]
C	YCR005C	CIT2	1189	-872.3	4	Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors [Source:SGD;Acc:S000000598]
C	YCR006C	YCR006C	8	-2.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000599]
C	YCR007C	YCR007C	19	-13.1	4	Putative integral membrane protein, member of DUP240 gene family; YCR007C is not an essential gene [Source:SGD;Acc:S000000600]
C	YCR008W	SAT4	257	-1132.5	4	Ser/Thr protein kinase involved in salt tolerance; funtions in regulation of Trk1p-Trk2p potassium transporter; partially redundant with Hal5p; has similarity to Npr1p [Source:SGD;Acc:S000000601]
C	YCR009C	RVS161	2065	-279.5	4	Amphiphysin-like lipid raft protein; interacts with Rvs167p and regulates polarization of the actin cytoskeleton, endocytosis, cell polarity, cell fusion and viability following starvation or osmotic stress [Source:SGD;Acc:S000000602]
C	YCR010C	ADY2	214	-114.7	4	Acetate transporter required for normal sporulation; phosphorylated in mitochondria [Source:SGD;Acc:S000000603]
C	YCR011C	ADP1	870	-334.6	4	Putative ATP-dependent permease of the ABC transporter family of proteins [Source:SGD;Acc:S000000604]
C	YCR012W	PGK1	6596	-2841.5	4	3-phosphoglycerate kinase, catalyzes transfer of high-energy phosphoryl groups from the acyl phosphate of 1,3-bisphosphoglycerate to ADP to produce ATP; key enzyme in glycolysis and gluconeogenesis [Source:SGD;Acc:S000000605]
C	YCR013C	YCR013C	11	-7.6	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YCR013C and the overlapping essential gene PGK1 is reduced in a gcr1 null mutant [Source:SGD;Acc:S000000606]
C	YCR014C	POL4	31	-134.7	4	DNA polymerase IV, undergoes pair-wise interactions with Dnl4p-Lif1p and Rad27p to mediate repair of DNA double-strand breaks by non-homologous end joining (NHEJ); homologous to mammalian DNA polymerase beta [Source:SGD;Acc:S000000607]
C	YCR015C	YCR015C	218	-95.6	4	Putative protein of unknown function; YCR015C is not an essential gene [Source:SGD;Acc:S000000608]
C	YCR016W	YCR016W	917	-192.8	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus and nucleus; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000000609]
C	YCR017C	CWH43	603	-236.1	4	Putative sensor/transporter protein involved in cell wall biogenesis; contains 14-16 transmembrane segments and several putative glycosylation and phosphorylation sites; null mutation is synthetically lethal with pkc1 deletion [Source:SGD;Acc:S000000610]
C	YCR018C	SRD1	33	-22.6	3	Protein involved in the processing of pre-rRNA to mature rRNA; contains a C2/C2 zinc finger motif; srd1 mutation suppresses defects caused by the rrp1-1 mutation [Source:SGD;Acc:S000000611]
C	YCR018C-A	YCR018C-A	0	nf	1	Putative protein of unknown function; encoded opposite a Ty1 LTR [Source:SGD;Acc:S000007230]
C	YCR019W	MAK32	116	-180.2	4	Protein necessary for structural stability of L-A double-stranded RNA-containing particles [Source:SGD;Acc:S000000612]
C	YCR020C	PET18	69	-204	4	Protein of unknown function, has weak similarity to proteins involved in thiamin metabolism; expression is induced in the absence of thiamin [Source:SGD;Acc:S000000613]
C	YCR020C-A	MAK31	51	-66.9	4	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus; member of the Sm protein family [Source:SGD;Acc:S000000614]
C	YCR020W-B	HTL1	369	-53	4	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance [Source:SGD;Acc:S000006439]
C	YCR021C	HSP30	461	-208.4	4	Hydrophobic plasma membrane localized, stress-responsive protein that negatively regulates the H(+)-ATPase Pma1p; induced by heat shock, ethanol treatment, weak organic acid, glucose limitation, and entry into stationary phase [Source:SGD;Acc:S000000615]
C	YCR022C	YCR022C	15	-1.9	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR022C is not an essential gene [Source:SGD;Acc:S000000616]
C	YCR023C	YCR023C	96	-100.4	4	Vacuolar membrane protein of unknown function; member of the multidrug resistance family; YCR023C is not an essential gene [Source:SGD;Acc:S000000617]
C	YCR024C	SLM5	205	-141.4	4	Mitochondrial asparaginyl-tRNA synthetase [Source:SGD;Acc:S000000618]
C	YCR024C-A	PMP1	0	nf	1	Small single-membrane span proteolipid that functions as a regulatory subunit of the plasma membrane H(+)-ATPase Pma1p, forms unique helix and positively charged cytoplasmic domain that is able to specifically segregate phosphatidylserines [Source:SGD;Acc:S000000619]
C	YCR024C-B	YCR024C-B	1	-1.4	1	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028818]
C	YCR025C	YCR025C	3	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YCR025C is not an essential gene [Source:SGD;Acc:S000000620]
C	YCR026C	NPP1	219	-188.9	4	Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation [Source:SGD;Acc:S000000621]
C	YCR027C	RHB1	343	-136.1	4	Putative Rheb-related GTPase involved in regulating canavanine resistance and arginine uptake; member of the Ras superfamily of G-proteins [Source:SGD;Acc:S000000622]
C	YCR028C	FEN2	22	-14.6	3	Plasma membrane H+-pantothenate symporter; confers sensitivity to the antifungal agent fenpropimorph [Source:SGD;Acc:S000000623]
C	YCR028C-A	RIM1	2135	-220.9	4	Single-stranded DNA-binding protein essential for mitochondrial genome maintenance; involved in mitochondrial DNA replication [Source:SGD;Acc:S000007222]
C	YCR030C	SYP1	1970	-688.3	4	Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization [Source:SGD;Acc:S000000626]
C	YCR031C	RPS14A	4962	-607.9	4	Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Bp and similar to E. coli S11 and rat S14 ribosomal proteins [Source:SGD;Acc:S000000627]
C	YCR032W	BPH1	144	-463.7	4	PProtein homologous to human Chediak-Higashi syndrome and murine Beige proteins, which are implicated in disease syndromes due to defective lysosomal trafficking; mutant phenotype and genetic interactions suggest a role in protein sorting [Source:SGD;Acc:S000000628]
C	YCR033W	SNT1	498	-283	4	Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000000629]
C	YCR034W	ELO2	937	-145.4	4	Fatty acid elongase, involved in sphingolipid biosynthesis; acts on fatty acids of up to 24 carbons in length; mutations have regulatory effects on 1,3-beta-glucan synthase, vacuolar ATPase, and the secretory pathway [Source:SGD;Acc:S000000630]
C	YCR035C	RRP43	569	-423.6	4	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp43p (OIP2, EXOSC8) [Source:SGD;Acc:S000000631]
C	YCR036W	RBK1	512	-174.6	4	Putative ribokinase [Source:SGD;Acc:S000000632]
C	YCR037C	PHO87	263	-195.9	4	Low-affinity inorganic phosphate (Pi) transporter, involved in activation of PHO pathway; expression is independent of Pi concentration and Pho4p activity; contains 12 membrane-spanning segments [Source:SGD;Acc:S000000633]
C	YCR038C	BUD5	31	-61.1	4	GTP/GDP exchange factor for Rsr1p (Bud1p) required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types [Source:SGD;Acc:S000000634]
C	YCR038W-A	YCR038W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene BUD5/YCR038C; identified by homology with hemiascomycetous yeast species [Source:SGD;Acc:S000007597]
C	YCR039C	MATALPHA2	74	-93.4	4	Homeobox-domain protein that, with Mcm1p, represses a-specific genes in haploids; acts with A1p to repress transcription of haploid-specific genes in diploids; one of two genes encoded by the MATalpha mating type cassette [Source:SGD;Acc:S000000635]
C	YCR040W	MATALPHA1	3	-1.2	1	Transcriptional co-activator involved in regulation of mating-type-specific gene expression; targets the transcription factor Mcm1p to the promoters of alpha-specific genes; one of two genes encoded by the MATalpha mating type cassette [Source:SGD;Acc:S000000636]
C	YCR041W	YCR041W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000637]
C	YCR042C	TAF2	424	-487.9	4	TFIID subunit (150 kDa), involved in RNA polymerase II transcription initiation [Source:SGD;Acc:S000000638]
C	YCR043C	YCR043C	212	-117.6	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi apparatus; YCR043C is not an essential gene [Source:SGD;Acc:S000000639]
C	YCR044C	PER1	57	-59.8	4	Protein of the endoplasmic reticulum, required for GPI-phospholipase A2 activity that remodels the GPI anchor as a prerequisite for association of GPI-anchored proteins with lipid rafts; functionally complemented by human ortholog PERLD1 [Source:SGD;Acc:S000000640]
C	YCR045C	RRT12	41	-18.9	4	Probable subtilisin-family protease with a role in formation of the dityrosine layer of spore walls; localizes to the spore wall and also the nuclear envelope and ER region in mature spores [Source:SGD;Acc:S000000641]
C	YCR045W-A	YCR045W-A	8	-4.6	2	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with YCR045C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028607]
C	YCR046C	IMG1	647	-165.3	4	Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome [Source:SGD;Acc:S000000642]
C	YCR047C	BUD23	481	-146	4	Methyltransferase, methylates residue G1575 of 18S rRNA; required for rRNA processing and nuclear export of 40S ribosomal subunits independently of methylation activity; diploid mutant displays random budding pattern [Source:SGD;Acc:S000000643]
C	YCR047W-A	YCR047W-A	2	-1.6	1	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with YCR047C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028608]
C	YCR048W	ARE1	314	-101.9	4	Acyl-CoA:sterol acyltransferase, isozyme of Are2p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the absence of oxygen [Source:SGD;Acc:S000000644]
C	YCR049C	YCR049C	4	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000645]
C	YCR050C	YCR050C	1	-1.4	1	Non-essential protein of unknown function; deletion mutant is synthetically sick or lethal with alpha-synuclein [Source:SGD;Acc:S000000646]
C	YCR051W	YCR051W	1032	-271.5	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; contains ankyrin (Ank) repeats; YCR051W is not an essential gene [Source:SGD;Acc:S000000647]
C	YCR052W	RSC6	991	-236.3	4	Component of the RSC chromatin remodeling complex; essential for mitotic growth; homolog of SWI/SNF subunit Swp73p [Source:SGD;Acc:S000000648]
C	YCR053W	THR4	3076	-1514.9	4	Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway [Source:SGD;Acc:S000000649]
C	YCR054C	CTR86	428	-321.4	4	Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at lo  ls [Source:SGD;Acc:S000000650]
C	YCR057C	PWP2	1270	-370.1	4	Conserved 90S pre-ribosomal component essential for proper endonucleolytic cleavage of the 35 S rRNA precursor at A0, A1, and A2 sites; contains eight WD-repeats; PWP2 deletion leads to defects in cell cycle and bud morphogenesis [Source:SGD;Acc:S000000653]
C	YCR059C	YIH1	227	-114.3	4	Protein that inhibits activation of Gcn2p, an eIF2 alpha subunit protein kinase, by competing for Gcn1p binding, thus impacting gene expression in response to starvation; has sequence and functional similarity to the mouse IMPACT gene [Source:SGD;Acc:S000000655]
C	YCR060W	TAH1	274	-83	4	HSP90 cofactor; interacts with Hsp82p, Pih1p, Rvb1 and Rvb2, contains a single TPR domain with at least two TPR motifs [Source:SGD;Acc:S000000656]
C	YCR061W	YCR061W	297	-153.5	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000000657]
C	YCR063W	BUD31	112	-74.9	4	Component of the SF3b subcomplex of the U2 snRNP; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern [Source:SGD;Acc:S000000659]
C	YCR064C	YCR064C	3	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31 [Source:SGD;Acc:S000000660]
C	YCR065W	HCM1	171	-113.8	4	Forkhead transcription factor that drives S-phase specific expression of genes involved in chromosome segregation, spindle dynamics, and budding; suppressor of calmodulin mutants with specific SPB assembly defects; telomere maintenance role [Source:SGD;Acc:S000000661]
C	YCR066W	RAD18	309	-163.8	4	E3 ubiqutin ligase, forms heterodimer with Rad6p to monoubiquitinate PCNA-K164; heterodimer binds single-stranded DNA and has single-stranded DNA dependent ATPase activity; required for postreplication repair [Source:SGD;Acc:S000000662]
C	YCR067C	SED4	300	-211.3	4	Integral endoplasmic reticulum membrane protein that stimulates Sar1p GTPase activity; involved in COPII vesicle budding through disassociation of coat proteins from membranes onto liposomes; binds Sec16p; similar to Sec12p [Source:SGD;Acc:S000000663]
C	YCR068W	ATG15	136	-139	4	Lipase required for intravacuolar lysis of autophagic bodies and Cvt bodies; targeted to intravacuolar vesicles during autophagy via the multivesicular body (MVB) pathway [Source:SGD;Acc:S000000664]
C	YCR069W	CPR4	236	-84	4	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway [Source:SGD;Acc:S000000665]
C	YCR071C	IMG2	312	-81.5	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000000667]
C	YCR072C	RSA4	785	-245	4	WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus [Source:SGD;Acc:S000000668]
C	YCR073C	SSK22	86	-1416.1	4	MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; functionally redundant with, and homologous to, Ssk2p; interacts with and is activated by Ssk1p; phosphorylates Pbs2p [Source:SGD;Acc:S000000669]
C	YCR073W-A	SOL2	969	-226.6	4	Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol1p, Sol3p, and Sol4p [Source:SGD;Acc:S000000718]
C	YCR075C	ERS1	10	-5.8	2	Protein with similarity to human cystinosin, which is a H(+)-driven transporter involved in L-cystine export from lysosomes and implicated in the disease cystinosis; contains seven transmembrane domains [Source:SGD;Acc:S000000671]
C	YCR075W-A	YCR075W-A	187	-53.6	4	Putative protein of unknown function; identified by homology to Ashbya gossypii [Source:SGD;Acc:S000028519]
C	YCR076C	FUB1	246	-97.5	4	Putative protein of unknown function; YCR076C is not an essential gene [Source:SGD;Acc:S000000672]
C	YCR077C	PAT1	1423	-1037.7	4	Topoisomerase II-associated deadenylation-dependent mRNA-decapping factor; also required for faithful chromosome transmission, maintenance of rDNA locus stability, and protection of mRNA 3'-UTRs from trimming; functionally linked to Pab1p [Source:SGD;Acc:S000000673]
C	YCR079W	PTC6	99	-851.1	4	Mitochondrial type 2C protein phosphatase (PP2C) with similarity to mammalian PP1Ks; involved in mitophagy; null mutant is sensitive to rapamycin and has decreased phosphorylation of the Pda1 subunit of pyruvate dehydrogenase [Source:SGD;Acc:S000002133]
C	YCR081C-A	YCR081C-A	1	-1.1	1	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with SRB8/YCR081W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028609]
C	YCR081W	SRB8	130	-258.2	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression [Source:SGD;Acc:S000000677]
C	YCR082W	AHC2	76	-58.7	4	Component of the ADA histone acetyltransferase complex; Ach2p and Ach1p are unique to the ADA complex and not shared with the related SAGA and SLIK complexes; may tether Ach1p to the complex [Source:SGD;Acc:S000000678]
C	YCR083W	TRX3	688	-143.3	4	Mitochondrial thioredoxin, highly conserved oxidoreductase required to maintain the redox homeostasis of the cell, forms the mitochondrial thioredoxin system with Trr2p, redox state is maintained by both Trr2p and Glr1p [Source:SGD;Acc:S000000679]
C	YCR084C	TUP1	2173	-640.6	4	General repressor of transcription, forms complex with Cyc8p, involved in the establishment of repressive chromatin structure through interactions with histones H3 and H4, appears to enhance expression of some genes [Source:SGD;Acc:S000000680]
C	YCR085W	YCR085W	2	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000681]
C	YCR086W	CSM1	317	-118.4	4	Nucleolar protein that forms a complex with Lrs4p and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation [Source:SGD;Acc:S000000682]
C	YCR087C-A	YCR087C-A	878	-104.6	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; YCR087C-A is not an essential gene [Source:SGD;Acc:S000007223]
C	YCR087W	YCR087W	8	-10	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene [Source:SGD;Acc:S000000683]
C	YCR088W	ABP1	3437	-931	4	Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization [Source:SGD;Acc:S000000684]
C	YCR089W	FIG2	8	-10.6	2	Cell wall adhesin, expressed specifically during mating; may be involved in maintenance of cell wall integrity during mating [Source:SGD;Acc:S000000685]
C	YCR090C	YCR090C	573	-109.1	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YCR090C is not an essential gene [Source:SGD;Acc:S000000686]
C	YCR091W	KIN82	261	-1202.1	4	Putative serine/threonine protein kinase implicated in the regulation of phospholipid asymmetry through the activation of phospholipid translocases (flippases) Lem3p-Dnf1p/Dnf2p; similar to Fpk1p [Source:SGD;Acc:S000000687]
C	YCR092C	MSH3	215	-251.8	4	Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability [Source:SGD;Acc:S000000688]
C	YCR093W	CDC39	1844	-1303.1	4	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor [Source:SGD;Acc:S000000689]
C	YCR094W	CDC50	162	-179.2	4	Endosomal protein that interacts with phospholipid flippase Drs2p; interaction with Cdc50p is essential for Drs2p catalytic activity; mutations affect cell polarity and polarized growth; similar to Ynr048wp and Lem3p [Source:SGD;Acc:S000000690]
C	YCR095C	OCA4	242	-244.7	4	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts [Source:SGD;Acc:S000000691]
C	YCR095W-A	YCR095W-A	22	-4.7	2	Putative protein of unknown function [Source:SGD;Acc:S000029724]
C	YCR096C	HMRA2	52	-60.6	4	Silenced copy of a2 at HMR; similarity to Alpha2p; required along with a1p for inhibiting expression of the HO endonuclease in a/alpha HO/HO diploid cells with an active mating-type interconversion system [Source:SGD;Acc:S000000692]
C	YCR097W	HMRA1	9	-5.2	2	Silenced copy of a1 at HMR; homeobox corepressor that interacts with Alpha2p to repress haploid-specific gene transcription in diploid cells [Source:SGD;Acc:S000000694]
C	YCR097W-A	YCR097W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by homology to a hemiascomycetous yeast protein [Source:SGD;Acc:S000007632]
C	YCR098C	GIT1	101	-59.1	4	Plasma membrane permease, mediates uptake of glycerophosphoinositol and glycerophosphocholine as sources of the nutrients inositol and phosphate; expression and transport rate are regulated by phosphate and inositol availability [Source:SGD;Acc:S000000695]
C	YCR099C	YCR099C	7	-4.6	2	Putative protein of unknown function [Source:SGD;Acc:S000000696]
C	YCR100C	YCR100C	26	-8.8	4	Putative protein of unknown function [Source:SGD;Acc:S000000697]
C	YCR101C	YCR101C	11	-10.9	2	Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene [Source:SGD;Acc:S000000698]
C	YCR102C	YCR102C	366	-159.6	4	Putative protein of unknown function, involved in copper metabolism; similar to C. carbonum toxD gene; member of the quinone oxidoreductase family [Source:SGD;Acc:S000000699]
C	YCR102W-A	YCR102W-A	1	-2.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007231]
C	YCR104W	PAU3	8	-2.3	2	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme [Source:SGD;Acc:S000000701]
C	YCR105W	ADH7	55	-110.1	4	NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance [Source:SGD;Acc:S000000702]
C	YCR106W	RDS1	37	-25.2	2	Zinc cluster transcription factor involved in conferring resistance to cycloheximide [Source:SGD;Acc:S000000703]
C	YCR107W	AAD3	14	-9.9	2	Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role [Source:SGD;Acc:S000000704]
C	YCR108C	YCR108C	4	-1.4	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028536]
D	YDL001W	RMD1	252	-177	4	Cytoplasmic protein required for sporulation [Source:SGD;Acc:S000002159]
D	YDL002C	NHP10	407	-664.8	4	Protein related to mammalian high mobility group proteins; preferentially binds DNA ends, protecting them from exonucleatic cleavage; likely component of the chromatin-remodeling complex INO80 complex; proposed to be involved in DNA repair [Source:SGD;Acc:S000002160]
D	YDL003W	MCD1	352	-201.9	4	Essential subunit of the cohesin complex required for sister chromatid cohesion in mitosis and meiosis; apoptosis induces cleavage and translocation of a C-terminal fragment to mitochondria; expression peaks in S phase [Source:SGD;Acc:S000002161]
D	YDL004W	ATP16	975	-331.9	4	Delta subunit of the central stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated [Source:SGD;Acc:S000002162]
D	YDL005C	MED2	472	-188	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation [Source:SGD;Acc:S000002163]
D	YDL006W	PTC1	393	-285.8	4	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation [Source:SGD;Acc:S000002164]
D	YDL007C-A	YDL007C-A	1	-2.2	2	Putative protein of unknown function [Source:SGD;Acc:S000113557]
D	YDL007W	RPT2	2158	-628.5	4	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle [Source:SGD;Acc:S000002165]
D	YDL008W	APC11	73	-1728.8	4	Catalytic core subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; contains a RING-H2    that is required for activity [Source:SGD;Acc:S000002166]
D	YDL009C	YDL009C	15	-10.5	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YDL010W; YDL009C is not an essential gene [Source:SGD;Acc:S000002167]
D	YDL010W	GRX6	330	-153.7	4	Cis-golgi localized monothiol glutaredoxin that binds an iron-sulfur cluster; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; functional overlap with GRX7 [Source:SGD;Acc:S000002168]
D	YDL011C	YDL011C	3	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORF YDL010W [Source:SGD;Acc:S000002169]
D	YDL012C	YDL012C	284	-68.1	4	Tail-anchored plasma membrane protein containing a conserved CYSTM module, possibly involved in response to stress; may contribute to non-homologous end-joining (NHEJ) based on ydl012c htz1 double null phenotype [Source:SGD;Acc:S000002170]
D	YDL013W	SLX5	62	-229.3	4	Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex, stimulated by SUMO-modified substrates; contains a RING domain and two SIMs (SUMO-interacting motifs); forms SUMO-dependent nuclear foci, including DNA repair centers [Source:SGD;Acc:S000002171]
D	YDL014W	NOP1	3302	-545.1	4	Nucleolar protein, component of the small subunit processome complex, which is required for processing of pre-18S rRNA; has similarity to mammalian fibrillarin [Source:SGD;Acc:S000002172]
D	YDL015C	TSC13	784	-156.3	4	Enoyl reductase that catalyzes the last step in each cycle of very long chain fatty acid elongation, localizes to the ER, highly enriched in a structure marking nuclear-vacuolar junctions, coimmunoprecipitates with elongases Fen1p and Sur4p [Source:SGD;Acc:S000002173]
D	YDL016C	YDL016C	6	-2.5	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CDC7/YDL153C, the catalytic subunit of a complex that regulates DNA replication [Source:SGD;Acc:S000002174]
D	YDL017W	CDC7	111	-1567.9	4	DDK (Dbf4-dependent kinase) catalytic subunit required for firing origins and replication fork progression in S phase through phosphorylation of Mcm2-7p complexes and Cdc45p; kinase activity correlates with cyclical DBF4 expression [Source:SGD;Acc:S000002175]
D	YDL018C	ERP3	210	-83.8	4	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport [Source:SGD;Acc:S000002176]
D	YDL019C	OSH2	1520	-803.6	4	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability [Source:SGD;Acc:S000002177]
D	YDL020C	RPN4	26	-25.7	3	Transcription factor that stimulates expression of proteasome genes; Rpn4p levels are in turn regulated by the 26S proteasome in a negative feedback control mechanism; RPN4 is transcriptionally regulated by various stress responses [Source:SGD;Acc:S000002178]
D	YDL021W	GPM2	678	-259	4	Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event [Source:SGD;Acc:S000002179]
D	YDL022C-A	YDL022C-A	1	-8.2	2	Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene DIA3; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028537]
D	YDL022W	GPD1	3014	-505.5	4	NAD-dependent glycerol-3-phosphate dehydrogenase, key enzyme of glycerol synthesis, essential for growth under osmotic stress; expression regulated by high-osmolarity glycerol response pathway; homolog of Gpd2p [Source:SGD;Acc:S000002180]
D	YDL023C	YDL023C	1	-2.3	2	Dubious open reading frame, unlikely to encode a protein; not conserved in other Saccharomyces species; overlaps the verified gene GPD1; deletion confers sensitivity to GSAO; deletion in cyr1 mutant results in loss of stress resistance [Source:SGD;Acc:S000002181]
D	YDL024C	DIA3	23	-27	2	Protein of unknown function, involved in invasive and pseudohyphal growth [Source:SGD;Acc:S000002182]
D	YDL025C	RTK1	934	-1881.1	4	Putative protein kinase, potentially phosphorylated by Cdc28p; interacts with ribosome biogenesis factors, Cka2, Gus1 and Arc1 [Source:SGD;Acc:S000002183]
D	YDL025W-A	YDL025W-A	0	nf	1	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the ORF YDL025C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028610]
D	YDL026W	YDL026W	0	nf	1	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002184]
D	YDL027C	YDL027C	176	-94.3	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL027C is not an essential gene [Source:SGD;Acc:S000002185]
D	YDL028C	MPS1	104	-2272	4	Dual-specificity kinase required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, and checkpoint protein Mad1p [Source:SGD;Acc:S000002186]
D	YDL029W	ARP2	2101	-462.7	4	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity [Source:SGD;Acc:S000002187]
D	YDL030W	PRP9	377	-365.4	4	Subunit of the SF3a splicing factor complex, required for spliceosome assembly; acts after the formation of the U1 snRNP-pre-mRNA complex [Source:SGD;Acc:S000002188]
D	YDL031W	DBP10	1392	-657.7	4	Putative ATP-dependent RNA helicase of the DEAD-box protein family, constituent of 66S pre-ribosomal particles; essential protein involved in ribosome biogenesis [Source:SGD;Acc:S000002189]
D	YDL032W	YDL032W	3	-2.6	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene SLM3/YDL033C; YDL032W is not an essential gene [Source:SGD;Acc:S000002190]
D	YDL033C	SLM3	125	-188	4	tRNA-specific 2-thiouridylase, responsible for 2-thiolation of the wobble base of mitochondrial tRNAs; human ortholog is implicated in myoclonus epilepsy associated with ragged red fibers (MERRF) [Source:SGD;Acc:S000002191]
D	YDL034W	YDL034W	1	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps with verified gene GPR1/YDL035C; YDL034W is not an essential gene [Source:SGD;Acc:S000002192]
D	YDL035C	GPR1	180	-148.9	4	Plasma membrane G protein coupled receptor (GPCR) that interacts with the heterotrimeric G protein alpha subunit, Gpa2p, and with Plc1p; sensor that integrates nutritional signals with the modulation of cell fate via PKA and cAMP synthesis [Source:SGD;Acc:S000002193]
D	YDL036C	PUS9	105	-67.9	4	Mitochondrial tRNA:pseudouridine synthase, catalyzes the formation of pseudouridine at position 32 in mitochondrial tRNAs; contains an N-terminal mitochondrial targeting sequence [Source:SGD;Acc:S000002194]
D	YDL037C	BSC1	6	-1.8	1	Protein of unconfirmed function, similar to cell surface flocculin Muc1p; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression [Source:SGD;Acc:S000002195]
D	YDL039C	PRM7	3	-11.8	2	Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements [Source:SGD;Acc:S000002197]
D	YDL040C	NAT1	2292	-1069	4	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing [Source:SGD;Acc:S000002198]
D	YDL041W	YDL041W	12	-7.6	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIR2/YDL042C [Source:SGD;Acc:S000002199]
D	YDL042C	SIR2	469	-2071.4	4	Conserved NAD+ dependent histone deacetylase of the Sirtuin family involved in regulation of lifespan; plays roles in silencing at HML, HMR, telomeres, and the rDNA locus; negatively regulates initiation of DNA replication [Source:SGD;Acc:S000002200]
D	YDL043C	PRP11	226	-119.2	4	Subunit of the SF3a splicing factor complex, required for spliceosome assembly [Source:SGD;Acc:S000002201]
D	YDL044C	MTF2	278	-257.8	4	Mitochondrial matrix protein that interacts with an N-terminal region of mitochondrial RNA polymerase (Rpo41p) and couples RNA processing and translation to transcription [Source:SGD;Acc:S000002202]
D	YDL045C	FAD1	280	-212.5	4	Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin [Source:SGD;Acc:S000002203]
D	YDL045W-A	MRP10	164	-42.1	4	Mitochondrial ribosomal protein of the small subunit; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000006430]
D	YDL046W	NPC2	639	-606	4	Functional homolog of human NPC2/He1, which is a cholesterol-binding protein whose deficiency causes Niemann-Pick type C2 disease involving retention of cholesterol in lysosomes [Source:SGD;Acc:S000002204]
D	YDL047W	SIT4	754	-557.3	4	Type 2A-related serine-threonine phosphatase that functions in the G1/S transition of the mitotic cycle; cytoplasmic and nuclear protein that modulates functions mediated by Pkc1p including cell wall and actin cytoskeleton organization [Source:SGD;Acc:S000002205]
D	YDL048C	STP4	125	-63.5	4	Protein containing a Kruppel-type zinc-finger domain; has similarity to Stp1p, Stp2p, and Stp3p [Source:SGD;Acc:S000002206]
D	YDL049C	KNH1	9	-17.4	2	Protein with similarity to Kre9p, which is involved in cell wall beta 1,6-glucan synthesis; overproduction suppresses growth defects of a kre9 null mutant; required for propionic acid resistance [Source:SGD;Acc:S000002207]
D	YDL050C	YDL050C	5	-1.7	1	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002208]
D	YDL051W	LHP1	1951	-313.8	4	RNA binding protein required for maturation of tRNA and U6 snRNA precursors; acts as a molecular chaperone for RNAs transcribed by polymerase III; homologous to human La (SS-B) autoantigen [Source:SGD;Acc:S000002209]
D	YDL052C	SLC1	1310	-339.2	4	1-acyl-sn-glycerol-3-phosphate acyltransferase, catalyzes the acylation of lysophosphatidic acid to form phosphatidic acid, a key intermediate in lipid metabolism; enzymatic activity detected in lipid particles and microsomes [Source:SGD;Acc:S000002210]
D	YDL053C	PBP4	1084	-135.3	4	Pbp1p binding protein, interacts strongly with Pab1p-binding protein 1 (Pbp1p) in the yeast two-hybrid system; also interacts with Lsm12p in a copurification assay [Source:SGD;Acc:S000002211]
D	YDL054C	MCH1	102	-40	4	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport [Source:SGD;Acc:S000002212]
D	YDL055C	PSA1	4253	-1018.7	4	GDP-mannose pyrophosphorylase (mannose-1-phosphate guanyltransferase), synthesizes GDP-mannose from GTP and mannose-1-phosphate in cell wall biosynthesis; required for normal cell wall structure [Source:SGD;Acc:S000002213]
D	YDL056W	MBP1	439	-317.2	4	Transcription factor involved in regulation of cell cycle progression from G1 to S phase, forms a complex with Swi6p that binds to MluI cell cycle box regulatory element in promoters of DNA synthesis genes [Source:SGD;Acc:S000002214]
D	YDL057W	YDL057W	130	-84	4	Putative protein of unknown function; YDL057W is not an essential gene [Source:SGD;Acc:S000002215]
D	YDL058W	USO1	1305	-1173.5	4	Essential protein involved in the vesicle-mediated ER to Golgi transport step of secretion; binds membranes and functions during vesicle docking to the Golgi; required for assembly of the ER-to-Golgi SNARE complex [Source:SGD;Acc:S000002216]
D	YDL059C	RAD59	64	-144.3	4	Protein involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; homologous to Rad52p [Source:SGD;Acc:S000002217]
D	YDL060W	TSR1	1314	-469.7	4	Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p [Source:SGD;Acc:S000002218]
D	YDL061C	RPS29B	2435	-144.7	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Ap and has similarity to rat S29 and E. coli S14 ribosomal proteins [Source:SGD;Acc:S000002219]
D	YDL062W	YDL062W	13	-5.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YDL063C; YDL062W is not essential [Source:SGD;Acc:S000002220]
D	YDL063C	SYO1	521	-286.1	4	Protein required for biogenesis of the large ribosomal subunit; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000002221]
D	YDL064W	UBC9	566	-142.8	4	SUMO-conjugating enzyme involved in the Smt3p conjugation pathway; nuclear protein required for S- and M-phase cyclin degradation and mitotic control; involved in proteolysis mediated by the anaphase-promoting complex cyclosome (APCC) [Source:SGD;Acc:S000002222]
D	YDL065C	PEX19	980	-291.6	4	Chaperone and import receptor for newly-synthesized class I peroxisomal membrane proteins (PMPs), binds PMPs in the cytoplasm and delivers them to the peroxisome for subsequent insertion into the peroxisomal membrane [Source:SGD;Acc:S000002223]
D	YDL066W	IDP1	3147	-976.1	4	Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes [Source:SGD;Acc:S000002224]
D	YDL067C	COX9	295	-66.3	4	Subunit VIIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain [Source:SGD;Acc:S000002225]
D	YDL068W	YDL068W	3	-4.2	2	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002226]
D	YDL069C	CBS1	41	-48	4	Mitochondrial translational activator of the COB mRNA; membrane protein that interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader [Source:SGD;Acc:S000002227]
D	YDL070W	BDF2	258	-115.1	4	Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf1p [Source:SGD;Acc:S000002228]
D	YDL071C	YDL071C	4	-9.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF BDF2/YDL070W [Source:SGD;Acc:S000002229]
D	YDL072C	YET3	1021	-277	4	Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein [Source:SGD;Acc:S000002230]
D	YDL073W	YDL073W	283	-96.9	4	Putative protein of unknown function; YDL073W is not an essential gene [Source:SGD;Acc:S000002231]
D	YDL074C	BRE1	847	-577.5	4	E3 ubiquitin ligase, forms heterodimer with Rad6p to monoubiquinate histone H2B-K123, which is required for the subsequent methylation of histone H3-K4 and H3-K79; required for DSBR, transcription, silencing, and checkpoint control [Source:SGD;Acc:S000002232]
D	YDL075W	RPL31A	3650	-598.7	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Bp and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality [Source:SGD;Acc:S000002233]
D	YDL076C	RXT3	277	-136	4	Subunit of the RPD3L complex; involved in histone deacetylation [Source:SGD;Acc:S000002234]
D	YDL077C	VAM6	289	-395.9	4	Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p [Source:SGD;Acc:S000002235]
D	YDL078C	MDH3	1989	-491.6	4	Peroxisomal malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the glyoxylate cycle [Source:SGD;Acc:S000002236]
D	YDL079C	MRK1	94	-639.8	4	Glycogen synthase kinase 3 (GSK-3) homolog; one of four GSK-3 homologs in S. cerevisiae that function to activate Msn2p-dependent transcription of stress responsive genes and that function in protein degradation [Source:SGD;Acc:S000002237]
D	YDL080C	THI3	1908	-353.4	4	Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis [Source:SGD;Acc:S000002238]
D	YDL081C	RPP1A	2256	-778	4	Ribosomal stalk protein P1 alpha, involved in the interaction between translational elongation factors and the ribosome; accumulation of P1 in the cytoplasm is regulated by phosphorylation and interaction with the P2 stalk component [Source:SGD;Acc:S000002239]
D	YDL082W	RPL13A	4322	-638.9	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Bp; not essential for viability; has similarity to rat L13 ribosomal protein [Source:SGD;Acc:S000002240]
D	YDL083C	RPS16B	4294	-544.6	4	Protein component of the small (40S) ribosomal subunit; identical to Rps16Ap and has similarity to E. coli S9 and rat S16 ribosomal proteins [Source:SGD;Acc:S000002241]
D	YDL084W	SUB2	3868	-814	4	Component of the TREX complex required for nuclear mRNA export; member of the DEAD-box RNA helicase superfamily and is involved in early and late steps of spliceosome assembly; homolog of the human splicing factor hUAP56 [Source:SGD;Acc:S000002242]
D	YDL085C-A	YDL085C-A	159	-56.5	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000007588]
D	YDL085W	NDE2	331	-571.2	4	Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain [Source:SGD;Acc:S000002243]
D	YDL086C-A	YDL086C-A	2	-1.3	1	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps uncharacterized ORF YDL086W; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028611]
D	YDL086W	YDL086W	1333	-443.9	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YDL086W is not an essential gene [Source:SGD;Acc:S000002244]
D	YDL087C	LUC7	199	-304.6	4	Essential protein associated with the U1 snRNP complex; splicing factor involved in recognition of 5' splice site; contains two zinc finger motifs; N-terminal zinc finger binds pre-mRNA [Source:SGD;Acc:S000002245]
D	YDL088C	ASM4	755	-491.9	4	Nuclear pore complex subunit, part of a subcomplex also containing Nup53p, Nup170p, and Pse1p [Source:SGD;Acc:S000002246]
D	YDL089W	NUR1	252	-137.2	4	Protein of unknown function; interacts with Csm1p, Lrs4p; required for rDNA repeat stability; null mutant causes increase in unequal sister-chromatid exchange; GFP-fusion protein localizes to the nuclear periphery, possible Cdc28p substrate [Source:SGD;Acc:S000002247]
D	YDL090C	RAM1	212	-154.1	4	Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit [Source:SGD;Acc:S000002248]
D	YDL091C	UBX3	276	-221.9	4	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000002249]
D	YDL092W	SRP14	1001	-124.1	4	Signal recognition particle (SRP) subunit, interacts with the RNA component of SRP to form the Alu domain, which is the region of SRP responsible for arrest of nascent chain elongation during membrane targeting; homolog of mammalian SRP14 [Source:SGD;Acc:S000002250]
D	YDL093W	PMT5	104	-93.6	4	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt3p, can instead interact with Pmt2p in some conditions; target for new antifungals [Source:SGD;Acc:S000002251]
D	YDL094C	YDL094C	5	-10.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verfied gene PMT5/YDL093W; YDL094C is not essential [Source:SGD;Acc:S000002252]
D	YDL095W	PMT1	1884	-639.3	4	Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein Ser/Thr residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control [Source:SGD;Acc:S000002253]
D	YDL096C	OPI6	5	-7.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential [Source:SGD;Acc:S000002254]
D	YDL097C	RPN6	2037	-669.9	4	Essential, non-ATPase regulatory subunit of the 26S proteasome lid required for the assembly and activity of the 26S proteasome; the human homolog (S9 protein) partially rescues Rpn6p depletion [Source:SGD;Acc:S000002255]
D	YDL098C	SNU23	188	-98	4	Component of U4/U6.U5 snRNP involved in mRNA splicing via spliceosome [Source:SGD;Acc:S000002256]
D	YDL099W	BUG1	834	-357.6	4	Cis-golgi localized protein involved in ER to Golgi transport; forms a complex with the mammalian GRASP65 homolog, Grh1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes [Source:SGD;Acc:S000002257]
D	YDL100C	GET3	2229	-482.6	4	Guanine nucleotide exchange factor for Gpa1p; amplifies G protein signaling; subunit of the GET complex, which is involved in Golgi to ER trafficking and insertion of proteins into the ER membrane; has low-level ATPase activity [Source:SGD;Acc:S000002258]
D	YDL101C	DUN1	524	-1134.8	4	Cell-cycle checkpoint serine-threonine kinase required for DNA damage-induced transcription of certain target genes, phosphorylation of Rad55p and Sml1p, and transient G2/M arrest after DNA damage; also regulates postreplicative DNA repair [Source:SGD;Acc:S000002259]
D	YDL102W	POL3	658	-420.4	4	Catalytic subunit of DNA polymerase delta; required for chromosomal DNA replication during mitosis and meiosis, intragenic recombination, repair of double strand DNA breaks, and DNA replication during nucleotide excision repair (NER) [Source:SGD;Acc:S000002260]
D	YDL103C	QRI1	1564	-546.5	4	UDP-N-acetylglucosamine pyrophosphorylase, catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis [Source:SGD;Acc:S000002261]
D	YDL104C	QRI7	133	-202.9	4	Highly conserved mitochondrial protein, essential for t6A modification of mitochondrial tRNAs that decode ANN codons; similar to Kae1p and E. coli YgjD, both of which are also required for tRNA t6A modification [Source:SGD;Acc:S000002262]
D	YDL105W	NSE4	127	-114.4	4	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair [Source:SGD;Acc:S000002263]
D	YDL106C	PHO2	283	-283	4	Homeobox transcription factor; regulatory targets include genes involved in phosphate metabolism; binds cooperatively with Pho4p to the PHO5 promoter; phosphorylation of Pho2p facilitates interaction with Pho4p [Source:SGD;Acc:S000002264]
D	YDL107W	MSS2	133	-91.8	4	Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p [Source:SGD;Acc:S000002265]
D	YDL108W	KIN28	331	-547	4	Serine/threonine protein kinase, subunit of the transcription factor TFIIH; involved in transcription initiation at RNA polymerase II promoters [Source:SGD;Acc:S000002266]
D	YDL109C	YDL109C	17	-2.3	2	Putative lipase; involved in lipid metabolism; YDL109C is not an essential gene [Source:SGD;Acc:S000002267]
D	YDL110C	TMA17	1250	-223.4	4	Protein of unknown function that associates with ribosomes; heterozygous deletion demonstrated increases in chromosome instability in a rad9 deletion background; protein abundance is decreased upon intracellular iron depletion [Source:SGD;Acc:S000002268]
D	YDL111C	RRP42	584	-255.2	4	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp42p (EXOSC7) [Source:SGD;Acc:S000002269]
D	YDL112W	TRM3	1036	-826.4	4	2'-O-ribose methyltransferase, catalyzes the ribose methylation of the guanosine nucleotide at position 18 of tRNAs [Source:SGD;Acc:S000002270]
D	YDL113C	ATG20	386	-299.9	4	Sorting nexin family member required for the cytoplasm-to-vacuole targeting (Cvt) pathway and for endosomal sorting; has a Phox homology domain that binds phosphatidylinositol-3-phosphate; interacts with Snx4p; potential Cdc28p substrate [Source:SGD;Acc:S000002271]
D	YDL114W	YDL114W	8	-9.5	1	Putative protein of unknown function with similarity to acyl-carrier-protein reductases; YDL114W is not an essential gene [Source:SGD;Acc:S000002272]
D	YDL114W-A	YDL114W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified based on homology to hemiascomycetous yeasts [Source:SGD;Acc:S000007598]
D	YDL115C	IWR1	295	-140.2	4	RNA polymerase II transport factor, conserved from yeast to humans; involved in both basal and regulated transcription from RNA polymerase II (RNAP II) promoters, but not itself a transcription factor; interacts with most of the RNAP II subunits; nu  ytoplasmic shuttling protein; deletion causes hypersensitivity to K1 killer toxin [Source:SGD;Acc:S000002273]
D	YDL116W	NUP84	962	-1034.7	4	Subunit of the nuclear pore complex (NPC); forms a subcomplex with Nup85p, Nup120p, Nup145p-C, Sec13p, and Seh1p that plays a role in nuclear mRNA export, and NPC biogenesis; required also for transcription elongation as demonstrated by the G-less-b  un-on (GLRO) assay [Source:SGD;Acc:S000002274]
D	YDL117W	CYK3	414	-227.5	4	SH3-domain protein located in the mother-bud neck and the cytokinetic actin ring; mutant phenotype and genetic interactions suggest a role in cytokinesis [Source:SGD;Acc:S000002275]
D	YDL118W	YDL118W	3	-1.2	1	Non-essential protein of unconfirmed function; mutants are defective in telomere maintenance, and are synthetically sick or lethal with alpha-synuclein [Source:SGD;Acc:S000002276]
D	YDL119C	YDL119C	124	-140.5	4	Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria [Source:SGD;Acc:S000002277]
D	YDL120W	YFH1	454	-79.2	4	Mitochondrial matrix iron chaperone; oxidizes and stores iron; interacts with Isu1p to promote Fe-S cluster assembly; mutation results in multiple Fe/S-dependent enzyme deficiencies; human frataxin homolog is mutated in Friedrich's ataxia [Source:SGD;Acc:S000002278]
D	YDL121C	YDL121C	588	-93.4	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDL121C is not an essential protein [Source:SGD;Acc:S000002279]
D	YDL122W	UBP1	1423	-509.9	4	Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains [Source:SGD;Acc:S000002280]
D	YDL123W	SNA4	89	-72.5	4	Protein of unknown function, localized to the vacuolar outer membrane; predicted to be palmitoylated [Source:SGD;Acc:S000002281]
D	YDL124W	YDL124W	2462	-638.3	4	NADPH-dependent alpha-keto amide reductase; reduces aromatic alpha-keto amides, aliphatic alpha-keto esters, and aromatic alpha-keto esters; member of the aldo-keto reductase (AKR) family [Source:SGD;Acc:S000002282]
D	YDL125C	HNT1	1894	-225	4	Adenosine 5'-monophosphoramidase; interacts physically and genetically with Kin28p, a CDK and TFIIK subunit, and genetically with CAK1; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins and similar to Hint [Source:SGD;Acc:S000002283]
D	YDL126C	CDC48	4645	-1722.9	4	ATPase involved in ubiquitin-mediated protein degradation; Cdc48p-Npl4p-Ufd1p complex participates in ER-associated degradation (ERAD) while Cdc48p-Npl4p-Vms1p complex participates in mitochondria-associated degradation (MAD); along with Npl4-Ufd1 c  , important for maintaining the cell wall integrity during heat stress to allow G1 progression; controls the proteasome-mediated degradation of Sec23p; mediates UV-induced degradation of ubiquitinated chromatin-bound Rpb1p [Source:SGD;Acc:S000002284]
D	YDL127W	PCL2	22	-12.4	2	Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth [Source:SGD;Acc:S000002285]
D	YDL128W	VCX1	826	-76.4	4	Vacuolar membrane antiporter with Ca2+/H+ and K+/H+ exchange activity, involved in control of cytosolic Ca2+ and K+ concentrations; has similarity to sodium/calcium exchangers, including the bovine Na+/Ca2+,K+ antiporter [Source:SGD;Acc:S000002286]
D	YDL129W	YDL129W	48	-48.1	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; YDL129W is not an essential gene [Source:SGD;Acc:S000002287]
D	YDL130W	RPP1B	3227	-721.4	4	Ribosomal protein P1 beta, component of the ribosomal stalk, which is involved in interaction of translational elongation factors with ribosome; accumulation is regulated by phosphorylation and interaction with the P2 stalk component [Source:SGD;Acc:S000002288]
D	YDL130W-A	STF1	328	-218.9	4	Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein [Source:SGD;Acc:S000007232]
D	YDL131W	LYS21	3433	-590.5	4	Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys20p [Source:SGD;Acc:S000002289]
D	YDL132W	CDC53	1180	-702	4	Cullin, structural protein of SCF complexes (which also contain Skp1p, Cdc34p, Hrt1p and an F-box protein) involved in ubiquitination; SCF promotes the G1-S transition by targeting G1 cyclins and the Cln-CDK inhibitor Sic1p for degradation [Source:SGD;Acc:S000002290]
D	YDL133C-A	RPL41B	0	nf	1	Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Ap and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable [Source:SGD;Acc:S000002293]
D	YDL133W	SRF1	297	-67.4	4	Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients [Source:SGD;Acc:S000002291]
D	YDL134C	PPH21	1039	-1402.1	4	Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph22p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis [Source:SGD;Acc:S000002292]
D	YDL135C	RDI1	1522	-300.4	4	Rho GDP dissociation inhibitor involved in the localization and regulation of Cdc42p and Rho1p [Source:SGD;Acc:S000002294]
D	YDL136W	RPL35B	3755	-452.7	4	Protein component of the large (60S) ribosomal subunit, identical to Rpl35Ap and has similarity to rat L35 ribosomal protein [Source:SGD;Acc:S000002295]
D	YDL137W	ARF2	2971	-427.3	4	ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated formation vesicles in intracellular trafficking within the Golgi; functionally interchangeable with Arf1p [Source:SGD;Acc:S000002296]
D	YDL138W	RGT2	19	-10.9	2	Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; highly similar to Snf3p [Source:SGD;Acc:S000002297]
D	YDL139C	SCM3	89	-55.8	4	Nonhistone component of centromeric chromatin that binds stoichiometrically to CenH3-H4 histones, required for kinetochore assembly; required for G2/M progression and localization of Cse4p; may protect Cse4p from ubiquitylation [Source:SGD;Acc:S000002298]
D	YDL140C	RPO21	2698	-5999	4	RNA polymerase II largest subunit B220, part of central core; phosphorylation of C-terminal heptapeptide repeat domain regulates association with transcription and splicing factors; similar to bacterial beta-prime [Source:SGD;Acc:S000002299]
D	YDL141W	BPL1	885	-494.6	4	Biotin:apoprotein ligase, covalently modifies proteins with the addition of biotin, required for acetyl-CoA carboxylase (Acc1p) holoenzyme formation [Source:SGD;Acc:S000002300]
D	YDL142C	CRD1	35	-37.9	4	Cardiolipin synthase; produces cardiolipin, which is a phospholipid of the mitochondrial inner membrane that is required for normal mitochondrial membrane potential and function; also required for normal vacuolar ion homeostasis [Source:SGD;Acc:S000002301]
D	YDL143W	CCT4	2662	-825.4	4	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo [Source:SGD;Acc:S000002302]
D	YDL144C	YDL144C	498	-302.3	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL144C is not an essential gene. [Source:SGD;Acc:S000002303]
D	YDL145C	COP1	3126	-1478.4	4	Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway [Source:SGD;Acc:S000002304]
D	YDL146W	LDB17	254	-153.8	4	Protein involved in the regulation of endocytosis; transiently recruited to actin cortical patches in a SLA1-dependent manner after late coat component assembly; GFP-fusion protein localizes to the periphery, cytoplasm, bud, and bud neck [Source:SGD;Acc:S000002305]
D	YDL147W	RPN5	1612	-670.9	4	Subunit of the COP9 signalosome (CSN) and non-ATPase regulatory subunit of the 26S proteasome lid, similar to mammalian p55 subunit and to another S. cerevisiae regulatory subunit, Rpn7p; Rpn5p is an essential protein [Source:SGD;Acc:S000002306]
D	YDL148C	NOP14	1165	-338.6	4	Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA [Source:SGD;Acc:S000002307]
D	YDL149W	ATG9	179	-250.4	4	Transmembrane protein involved in forming Cvt and autophagic vesicles; cycles between the phagophore assembly site (PAS) and other cytosolic punctate structures, not found in autophagosomes; may be involved in membrane delivery to the PAS [Source:SGD;Acc:S000002308]
D	YDL150W	RPC53	861	-321.2	4	RNA polymerase III subunit C53 [Source:SGD;Acc:S000002309]
D	YDL151C	BUD30	12	-3.6	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 96% of ORF overlaps the verified gene RPC53; diploid mutant displays a weak budding pattern phenotype in a systematic assay [Source:SGD;Acc:S000002310]
D	YDL152W	YDL152W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome [Source:SGD;Acc:S000002311]
D	YDL153C	SAS10	1636	-375.7	4	Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000002312]
D	YDL154W	MSH5	31	-8.9	2	Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans [Source:SGD;Acc:S000002313]
D	YDL155W	CLB3	65	-1783	4	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation [Source:SGD;Acc:S000002314]
D	YDL156W	CMR1	313	-182.8	4	Putative protein of unknown function; protein sequence contains three WD domains (WD-40 repeat); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; potential regulatory target of Mbp1p, which binds to the YDL156W   er region [Source:SGD;Acc:S000002315]
D	YDL157C	YDL157C	244	-75	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002316]
D	YDL158C	YDL158C	2	-1	1	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002317]
D	YDL159C-B	YDL159C-B	0	nf	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028612]
D	YDL159W	STE7	158	-1582.8	4	Signal transducing MAP kinase kinase involved in pheromone response, where it phosphorylates Fus3p, and in the pseudohyphal/invasive growth pathway, through phosphorylation of Kss1p; phosphorylated by Ste11p, degraded by ubiquitin pathway [Source:SGD;Acc:S000002318]
D	YDL159W-A	YDL159W-A	0	nf	1	Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species [Source:SGD;Acc:S000007599]
D	YDL160C	DHH1	2570	-801.6	4	Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p inter  ith Ngr1p and promotes POR1, but not EDC1 mRNA decay [Source:SGD;Acc:S000002319]
D	YDL160C-A	MHF2	159	-51.2	4	Putative protein of unknown function; mutant in a srs2 mutant background displays MMS hypersensitivity; ortholog of human MHF2, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability [Source:SGD;Acc:S000028520]
D	YDL161W	ENT1	1294	-441.6	4	Epsin-like protein involved in endocytosis and actin patch assembly and functionally redundant with Ent2p; binds clathrin via a clathrin-binding domain motif at C-terminus [Source:SGD;Acc:S000002320]
D	YDL162C	YDL162C	5	-3.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps ENT1/YDL161W, a verified gene involved in endocytosis and actin cortical patch assembly [Source:SGD;Acc:S000002321]
D	YDL163W	YDL163W	1	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene CDC9/YDL164C encoding DNA ligase [Source:SGD;Acc:S000002322]
D	YDL164C	CDC9	706	-439	4	DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination [Source:SGD;Acc:S000002323]
D	YDL165W	CDC36	480	-85.9	4	Component of the CCR4-NOT complex, which has multiple roles in regulating mRNA levels including regulation of transcription and destabilizing mRNAs by deadenylation; basal transcription factor [Source:SGD;Acc:S000002324]
D	YDL166C	FAP7	817	-161.1	4	Essential NTPase required for small ribosome subunit synthesis, mediates processing of the 20S pre-rRNA at site D in the cytoplasm but associates only transiently with 43S preribosomes via Rps14p, may be the endonuclease for site D [Source:SGD;Acc:S000002325]
D	YDL167C	NRP1	636	-162.6	4	Putative RNA binding protein of unknown function; localizes to stress granules induced by glucose deprivation; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000002326]
D	YDL168W	SFA1	1418	-282.7	4	Bifunctional enzyme containing both alcohol dehydrogenase and glutathione-dependent formaldehyde dehydrogenase activities, functions in formaldehyde detoxification and formation of long chain and complex alcohols, regulated by Hog1p-Sko1p [Source:SGD;Acc:S000002327]
D	YDL169C	UGX2	30	-31.3	4	Protein of unknown function, transcript accumulates in response to any combination of stress conditions [Source:SGD;Acc:S000002328]
D	YDL170W	UGA3	69	-120.9	4	Transcriptional activator necessary for gamma-aminobutyrate (GABA)-dependent induction of GABA genes (such as UGA1, UGA2, UGA4); zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type; localized to the nucleus [Source:SGD;Acc:S000002329]
D	YDL171C	GLT1	3003	-2464.2	4	NAD(+)-dependent glutamate synthase (GOGAT), synthesizes glutamate from glutamine and alpha-ketoglutarate; with Gln1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source [Source:SGD;Acc:S000002330]
D	YDL172C	YDL172C	3	-2.2	2	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002331]
D	YDL173W	PAR32	1251	-186.8	4	Putative protein of unknown function; hyperphosphorylated upon rapamycin treatment in a Tap42p-dependent manner; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; PAR32 is not an essential gene [Source:SGD;Acc:S000002332]
D	YDL174C	DLD1	1206	-878.2	4	D-lactate dehydrogenase, oxidizes D-lactate to pyruvate, transcription is heme-dependent, repressed by glucose, and derepressed in ethanol or lactate; located in the mitochondrial inner membrane [Source:SGD;Acc:S000002333]
D	YDL175C	AIR2	354	-176.1	4	Zinc knuckle protein, involved in nuclear RNA processing and degredation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air1p [Source:SGD;Acc:S000002334]
D	YDL176W	YDL176W	54	-506.7	4	Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene [Source:SGD;Acc:S000002335]
D	YDL177C	YDL177C	90	-81.3	4	Putative protein of unknown function; similar to the mouse IMPACT gene; YDL177C is not an essential gene [Source:SGD;Acc:S000002336]
D	YDL178W	DLD2	1066	-443.6	4	D-lactate dehydrogenase, located in the mitochondrial matrix [Source:SGD;Acc:S000002337]
D	YDL179W	PCL9	55	-370	4	Cyclin, forms a functional kinase complex with Pho85p cyclin-dependent kinase (Cdk), expressed in late M/early G1 phase, activated by Swi5p [Source:SGD;Acc:S000002338]
D	YDL180W	YDL180W	124	-106.2	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole [Source:SGD;Acc:S000002339]
D	YDL181W	INH1	695	-165.8	4	Protein that inhibits ATP hydrolysis by the F1F0-ATP synthase; inhibitory function is enhanced by stabilizing proteins Stf1p and Stf2p; has similarity to Stf1p; has a calmodulin-binding motif and binds calmodulin in vitro [Source:SGD;Acc:S000002340]
D	YDL182W	LYS20	3418	-580.2	4	Homocitrate synthase isozyme, catalyzes the condensation of acetyl-CoA and alpha-ketoglutarate to form homocitrate, which is the first step in the lysine biosynthesis pathway; highly similar to the other isozyme, Lys21p [Source:SGD;Acc:S000002341]
D	YDL183C	YDL183C	94	-99.4	4	Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene [Source:SGD;Acc:S000002342]
D	YDL184C	RPL41A	0	nf	1	Ribosomal protein L47 of the large (60S) ribosomal subunit, identical to Rpl41Bp and has similarity to rat L41 ribosomal protein; comprised of only 25 amino acids; rpl41a rpl41b double null mutant is viable [Source:SGD;Acc:S000002343]
D	YDL185C-A	YDL185C-A	2	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDL185W; identified by homology with hemiascomycetous yeast species [Source:SGD;Acc:S000007600]
D	YDL185W	VMA1	4684	-2284.2	4	Subunit A of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase; protein precursor undergoes self-catalyzed splicing to yield the extein Tfp1p and the intein Vde (PI-SceI), which is a site-specific endonuclease [Source:SGD;Acc:S000002344]
D	YDL186W	YDL186W	8	-2.3	2	Putative protein of unknown function; YDL186W is not an essential gene [Source:SGD;Acc:S000002345]
D	YDL187C	YDL187C	0	nf	1	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002346]
D	YDL188C	PPH22	1157	-944	4	Catalytic subunit of protein phosphatase 2A (PP2A), functionally redundant with Pph21p; methylated at C terminus; forms alternate complexes with several regulatory subunits; involved in signal transduction and regulation of mitosis [Source:SGD;Acc:S000002347]
D	YDL189W	RBS1	321	-119.8	4	Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain [Source:SGD;Acc:S000002348]
D	YDL190C	UFD2	1044	-572.8	4	Ubiquitin chain assembly factor (E4) that cooperates with a ubiquitin-activating enzyme (E1), a ubiquitin-conjugating enzyme (E2), and a ubiquitin protein ligase (E3) to conjugate ubiquitin to substrates; also functions as an E3 [Source:SGD;Acc:S000002349]
D	YDL191W	RPL35A	3755	-452.7	4	Protein component of the large (60S) ribosomal subunit, identical to Rpl35Bp and has similarity to rat L35 ribosomal protein [Source:SGD;Acc:S000002350]
D	YDL192W	ARF1	3093	-466.3	4	ADP-ribosylation factor, GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; functionally interchangeable with Arf2p [Source:SGD;Acc:S000002351]
D	YDL193W	NUS1	508	-307.1	4	Putative prenyltransferase, required for cell viability; proposed to be involved in protein trafficking because tet-repressible mutant shows accumulation of hypoglycosylated forms of CPY [Source:SGD;Acc:S000002352]
D	YDL194W	SNF3	66	-97.1	4	Plasma membrane low glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; also senses fructose and mannose; similar to Rgt2p [Source:SGD;Acc:S000002353]
D	YDL195W	SEC31	3128	-1501	4	Component of the Sec13p-Sec31p complex of the COPII vesicle coat, required for vesicle formation in ER to Golgi transport; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000002354]
D	YDL196W	YDL196W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31 [Source:SGD;Acc:S000002355]
D	YDL197C	ASF2	57	-44	4	Anti-silencing protein that causes derepression of silent loci when overexpressed [Source:SGD;Acc:S000002356]
D	YDL198C	GGC1	1622	-470.1	4	Mitochondrial GTP/GDP transporter, essential for mitochondrial genome maintenance; has a role in mitochondrial iron transport; member of the mitochondrial carrier family [Source:SGD;Acc:S000002357]
D	YDL199C	YDL199C	131	-121.1	4	Putative transporter, member of the sugar porter family [Source:SGD;Acc:S000002358]
D	YDL200C	MGT1	20	-22.7	4	DNA repair methyltransferase (6-O-methylguanine-DNA methylase) involved in protection against DNA alkylation damage [Source:SGD;Acc:S000002359]
D	YDL201W	TRM8	1159	-192.3	4	Noncatalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not boun  rm82p [Source:SGD;Acc:S000002360]
D	YDL202W	MRPL11	661	-132	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000002361]
D	YDL203C	ACK1	329	-224.2	4	Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria [Source:SGD;Acc:S000002362]
D	YDL204W	RTN2	898	-393.7	4	Protein of unknown function; has similarity to mammalian reticulon proteins; member of the RTNLA (reticulon-like A) subfamily [Source:SGD;Acc:S000002363]
D	YDL205C	HEM3	832	-259.9	4	Porphobilinogen deaminase, catalyzes the conversion of 4-porphobilinogen to hydroxymethylbilane, the third step in heme biosynthesis; localizes to the cytoplasm and nucleus; expression is regulated by Hap2p-Hap3p, but not by levels of heme [Source:SGD;Acc:S000002364]
D	YDL206W	YDL206W	59	-53.9	4	Putative protein of unknown function; YDL206W is not an essential protein [Source:SGD;Acc:S000002365]
D	YDL207W	GLE1	406	-360.8	4	Cytoplasmic nucleoporin required for polyadenylated RNA export; not essential for protein import; contains a nuclear export signal; when bound to inositol hexakisphosphate (IP6), functions as an activator for the Dbp5p ATPase activity at the nuclear  complex during mRNA export [Source:SGD;Acc:S000002366]
D	YDL208W	NHP2	1235	-156.2	4	Nuclear protein related to mammalian high mobility group (HMG) proteins, essential for function of H/ACA-type snoRNPs, which are involved in 18S rRNA processing [Source:SGD;Acc:S000002367]
D	YDL209C	CWC2	266	-236	4	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2 [Source:SGD;Acc:S000002368]
D	YDL210W	UGA4	16	-12.8	4	Permease that serves as a gamma-aminobutyrate (GABA) transport protein involved in the utilization of GABA as a nitrogen source; catalyzes the transport of putrescine and delta-aminolevulinic acid (ALA); localized to the vacuolar membrane [Source:SGD;Acc:S000002369]
D	YDL211C	YDL211C	18	-16.1	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole [Source:SGD;Acc:S000002370]
D	YDL212W	SHR3	313	-42.4	4	Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface [Source:SGD;Acc:S000002371]
D	YDL213C	NOP6	1317	-203.5	4	rRNA-binding protein required for 40S ribosomal subunit biogenesis; contains an RNA recognition motif (RRM) and has similarity to hydrophilins; NOP6 may be a fungal-specific gene as no homologs have been yet identified in higher eukaryotes [Source:SGD;Acc:S000002372]
D	YDL214C	PRR2	18	-1802.3	4	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000002373]
D	YDL215C	GDH2	1122	-2232	4	NAD(+)-dependent glutamate dehydrogenase, degrades glutamate to ammonia and alpha-ketoglutarate; expression sensitive to nitrogen catabolite repression and intracellular ammonia levels [Source:SGD;Acc:S000002374]
D	YDL216C	RRI1	62	-40.3	4	Catalytic subunit of the COP9 signalosome (CSN) complex that acts as an isopeptidase in cleaving the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; metalloendopeptidase involved in the adaptation to pheromone signaling [Source:SGD;Acc:S000002375]
D	YDL217C	TIM22	233	-135.3	4	Essential core component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; forms the channel through which proteins are imported [Source:SGD;Acc:S000002376]
D	YDL218W	YDL218W	102	-212.3	4	Putative protein of unknown function; YDL218W transcription is regulated by Azf1p and induced by starvation and aerobic conditions; expression also induced in cells treated with the mycotoxin patulin [Source:SGD;Acc:S000002377]
D	YDL219W	DTD1	438	-134.1	4	D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes [Source:SGD;Acc:S000002378]
D	YDL220C	CDC13	149	-115.7	4	Single stranded DNA-binding protein found at TG1-3 telomere G-tails; regulates telomere replication through recruitment of specific sub-complexes, but the essential function is telomere capping [Source:SGD;Acc:S000002379]
D	YDL221W	YDL221W	3	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 3' end of essential gene CDC13 [Source:SGD;Acc:S000002380]
D	YDL222C	FMP45	439	-348.9	4	Integral membrane protein localized to mitochondria (untagged protein); required for sporulation and maintaining sphingolipid content; has sequence similarity to SUR7 and YNL194C [Source:SGD;Acc:S000002381]
D	YDL223C	HBT1	1446	-1192.4	4	Substrate of the Hub1p ubiquitin-like protein that localizes to the shmoo tip (mating projection); mutants are defective for mating projection formation, thereby implicating Hbt1p in polarized cell morphogenesis [Source:SGD;Acc:S000002382]
D	YDL224C	WHI4	582	-187.1	4	Putative RNA binding protein and partially redundant Whi3p homolog that regulates the cell size requirement for passage through Start and commitment to cell division [Source:SGD;Acc:S000002383]
D	YDL225W	SHS1	1694	-1106	4	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds f  ruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; undergoes sumoylation and phosphorylation during mitosis [Source:SGD;Acc:S000002384]
D	YDL226C	GCS1	2033	-382.1	4	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p [Source:SGD;Acc:S000002385]
D	YDL227C	HO	89	-41.1	4	Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p [Source:SGD;Acc:S000002386]
D	YDL228C	YDL228C	3	-1.5	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene SSB1 [Source:SGD;Acc:S000002387]
D	YDL229W	SSB1	6961	-2907.1	4	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in folding of newly-made polypeptide chains; member of the HSP70 family; interacts with phosphatase subunit Reg1p [Source:SGD;Acc:S000002388]
D	YDL230W	PTP1	385	-465.3	4	Phosphotyrosine-specific protein phosphatase that dephosphorylates a broad range of substrates in vivo, including Fpr3p; localized to the cytoplasm and the mitochondria; proposed to be a negative regulator of filamentation [Source:SGD;Acc:S000002389]
D	YDL231C	BRE4	76	-18.4	4	Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport [Source:SGD;Acc:S000002390]
D	YDL232W	OST4	6	-10.4	2	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes protein asparagine-linked glycosylation; type I membrane protein required for incorporation of Ost3p or Ost6p into the OST complex [Source:SGD;Acc:S000002391]
D	YDL233W	MFG1	33	-39.6	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YDL233W is not an essential gene [Source:SGD;Acc:S000002392]
D	YDL234C	GYP7	453	-296.6	4	GTPase-activating protein for yeast Rab family members including: Ypt7p (most effective), Ypt1p, Ypt31p, and Ypt32p (in vitro); involved in vesicle mediated protein trafficking [Source:SGD;Acc:S000002393]
D	YDL235C	YPD1	826	-108.2	4	Phosphorelay intermediate protein, phosphorylated by the plasma membrane sensor Sln1p in response to osmotic stress and then in turn phosphorylates the response regulators Ssk1p in the cytosol and Skn7p in the nucleus [Source:SGD;Acc:S000002394]
D	YDL236W	PHO13	1231	-275.2	4	Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity [Source:SGD;Acc:S000002395]
D	YDL237W	AIM6	971	-372.3	4	Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene [Source:SGD;Acc:S000002396]
D	YDL238C	GUD1	126	-168.4	4	Guanine deaminase, a catabolic enzyme of the guanine salvage pathway producing xanthine and ammonia from guanine; activity is low in exponentially-growing cultures but expression is increased in post-diauxic and stationary-phase cultures [Source:SGD;Acc:S000002397]
D	YDL239C	ADY3	24	-11.5	2	Protein required for spore wall formation, thought to mediate assembly of a Don1p-containing structure at the leading edge of the prospore membrane via interaction with spindle pole body components; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000002398]
D	YDL240C-A	YDL240C-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species [Source:SGD;Acc:S000007601]
D	YDL240W	LRG1	410	-386.9	4	Putative GTPase-activating protein (GAP) involved in the Pkc1p-mediated signaling pathway that controls cell wall integrity; appears to specifically regulate 1,3-beta-glucan synthesis [Source:SGD;Acc:S000002399]
D	YDL241W	YDL241W	11	-9.1	2	Putative protein of unknown function; YDL241W is not an essential gene [Source:SGD;Acc:S000002400]
D	YDL242W	YDL242W	7	-2.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002401]
D	YDL243C	AAD4	9	-3.2	2	Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin [Source:SGD;Acc:S000002402]
D	YDL244W	THI13	53	-139.4	4	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 [Source:SGD;Acc:S000002403]
D	YDL245C	HXT15	234	-22.2	2	Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose [Source:SGD;Acc:S000002404]
D	YDL246C	SOR2	43	-112.3	4	Protein of unknown function; protein sequence is 99% identical to the Sor1p sorbitol dehydrogenase; computational analysis of large-scale protein-protein interaction data also suggests a role in fructose or mannose metabolism [Source:SGD;Acc:S000002405]
D	YDL247W	MPH2	17	-8.2	2	Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph3p; encoded in a subtelomeric position in a region likely to have undergone duplication [Source:SGD;Acc:S000002406]
D	YDL247W-A	YDL247W-A	1	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by sequence comparison with hemiascomycetous yeast species [Source:SGD;Acc:S000007602]
D	YDL248W	COS7	134	-46	4	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002407]
D	YDR001C	NTH1	1603	-763.4	4	Neutral trehalase, degrades trehalose; required for thermotolerance and may mediate resistance to other cellular stresses; may be phosphorylated by Cdc28p [Source:SGD;Acc:S000002408]
D	YDR002W	YRB1	2141	-354.3	4	Ran GTPase binding protein; involved in nuclear protein import and RNA export, ubiquitin-mediated protein degradation during the cell cycle; shuttles between the nucleus and cytoplasm; is essential; homolog of human RanBP1 [Source:SGD;Acc:S000002409]
D	YDR003W	RCR2	240	-128.6	4	Vacuolar protein that presumably functions within the endosomal-vacuolar trafficking pathway, affecting events that determine whether plasma membrane proteins are degraded or routed to the plasma membrane; similar to Rcr1p [Source:SGD;Acc:S000002410]
D	YDR003W-A	YDR003W-A	0	nf	1	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028819]
D	YDR004W	RAD57	17	-7.6	2	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p [Source:SGD;Acc:S000002411]
D	YDR005C	MAF1	505	-241.2	4	Highly conserved negative regulator of RNA polymerase III; binds to the N-terminal domain of the Rpc160p subunit of Pol III to prevent closed-complex formation; localization and activity are regulated by phosphorylation, mediated by TORC1, protein k  A, and Sch9p; localizes to cytoplasm during vegetative growth and translocates to the nucleus and nucleolus under stress conditions [Source:SGD;Acc:S000002412]
D	YDR006C	SOK1	653	-465.2	4	Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13 [Source:SGD;Acc:S000002413]
D	YDR007W	TRP1	348	-119.5	4	Phosphoribosylanthranilate isomerase that catalyzes the third step in tryptophan biosynthesis; in 2004, the sequence of TRP1 from strain S228C was updated by changing the previously annotated internal STOP (TAA) to serine (TCA) [Source:SGD;Acc:S000002414]
D	YDR008C	YDR008C	3	-2.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002415]
D	YDR009W	GAL3	265	-398.2	4	Transcriptional regulator involved in activation of the GAL genes in response to galactose; forms a complex with Gal80p to relieve Gal80p inhibition of Gal4p; binds galactose and ATP but does not have galactokinase activity [Source:SGD;Acc:S000002416]
D	YDR010C	YDR010C	5	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002417]
D	YDR011W	SNQ2	1514	-760.9	4	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter involved in multidrug resistance and resistance to singlet oxygen species [Source:SGD;Acc:S000002418]
D	YDR012W	RPL4B	5542	-1930.4	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl4Ap and has similarity to E. coli L4 and rat L4 ribosomal proteins [Source:SGD;Acc:S000002419]
D	YDR013W	PSF1	101	-76.7	4	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery [Source:SGD;Acc:S000002420]
D	YDR014W	RAD61	88	-161.1	4	Subunit of a complex (Scc3p, Pds5p, Rad61p) that inhibits sister chromatid cohesion; inhibited by Eco1p-acetylated cohesin subunits Smc3p and Mcd1p; related to the human Wapl protein that controls the association of cohesin with chromatin [Source:SGD;Acc:S000002421]
D	YDR014W-A	HED1	7	-12.4	2	Meiosis-specific protein that down-regulates Rad51p-mediated mitotic recombination when the meiotic recombination machinery is impaired; early meiotic gene, transcribed specifically during meiotic prophase [Source:SGD;Acc:S000113613]
D	YDR015C	YDR015C	3	-2.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HED1/YDR014W-A [Source:SGD;Acc:S000002422]
D	YDR016C	DAD1	138	-46.2	4	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis [Source:SGD;Acc:S000002423]
D	YDR017C	KCS1	928	-387.5	4	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; generation of high energy inositol pyrophosphates by Kcs1p is required for many processes such as vacuolar biogenesis, stress response and telomere maintenance [Source:SGD;Acc:S000002424]
D	YDR018C	YDR018C	12	-10.3	2	Probable membrane protein with three predicted transmembrane domains; homologous to Ybr042cp, similar to C. elegans F55A11.5 and maize 1-acyl-glycerol-3-phosphate acyltransferase [Source:SGD;Acc:S000002425]
D	YDR019C	GCV1	1419	-525	4	T subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of levels of 5,10-methylene-THF in the cytoplasm [Source:SGD;Acc:S000002426]
D	YDR020C	DAS2	251	-84.3	4	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; weak similarity with uridine kinases and with phosphoribokinases [Source:SGD;Acc:S000002427]
D	YDR021W	FAL1	466	-212.2	4	Nucleolar protein required for maturation of 18S rRNA, member of the eIF4A subfamily of DEAD-box ATP-dependent RNA helicases [Source:SGD;Acc:S000002428]
D	YDR022C	ATG31	67	-47.3	4	Autophagy-specific protein required for autophagosome formation; may form a complex with Atg17p and Atg29p that localizes other proteins to the pre-autophagosomal structure; high-copy suppressor of CIK1 deletion [Source:SGD;Acc:S000002429]
D	YDR023W	SES1	3384	-1117.6	4	Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p [Source:SGD;Acc:S000002430]
D	YDR024W	FYV1	6	-2.4	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; mutation decreases survival upon exposure to K1 killer toxin [Source:SGD;Acc:S000002431]
D	YDR025W	RPS11A	4408	-391.3	4	Protein component of the small (40S) ribosomal subunit; identical to Rps11Bp and has similarity to E. coli S17 and rat S11 ribosomal proteins [Source:SGD;Acc:S000002432]
D	YDR026C	NSI1	188	-200.7	4	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; Myb-like DNA-binding protein that may bind to the Ter region of rDNA; interacts physically with Fob1p [Source:SGD;Acc:S000002433]
D	YDR027C	VPS54	372	-269.6	4	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000002434]
D	YDR028C	REG1	1543	-697.1	4	Regulatory subunit of type 1 protein phosphatase Glc7p, involved in negative regulation of glucose-repressible genes [Source:SGD;Acc:S000002435]
D	YDR029W	YDR029W	6	-2.3	2	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002436]
D	YDR030C	RAD28	32	-19.8	4	Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair [Source:SGD;Acc:S000002437]
D	YDR031W	MIX14	420	-196.5	4	Mitochondrial intermembrane space protein, required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000002438]
D	YDR032C	PST2	2317	-429.1	4	Protein with similarity to members of a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002439]
D	YDR033W	MRH1	2386	-219.8	4	Protein that localizes primarily to the plasma membrane, also found at the nuclear envelope; the authentic, non-tagged protein is detected in mitochondria in a phosphorylated state; has similarity to Hsp30p and Yro2p [Source:SGD;Acc:S000002440]
D	YDR034C	LYS14	156	-97.3	4	Transcriptional activator involved in regulation of genes of the lysine biosynthesis pathway; requires 2-aminoadipate semialdehyde as co-inducer [Source:SGD;Acc:S000002441]
D	YDR034C-A	YDR034C-A	0	nf	1	Putative protein of unknown function; contained within the solo Ty1 LTR element YDRWdelta7 [Source:SGD;Acc:S000007233]
D	YDR034C-C	YDR034C-C	1043	-357.3	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007344]
D	YDR034C-D	YDR034C-D	2324	-724.8	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007345]
D	YDR034W-B	YDR034W-B	14	-11.9	4	Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000007234]
D	YDR035W	ARO3	2326	-581.6	4	3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase, catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by phenylalanine or high concentration of tyrosine or tryptophan [Source:SGD;Acc:S000002442]
D	YDR036C	EHD3	774	-375.7	4	3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis [Source:SGD;Acc:S000002443]
D	YDR037W	KRS1	3408	-1459.6	4	Lysyl-tRNA synthetase [Source:SGD;Acc:S000002444]
D	YDR038C	ENA5	1051	-365.3	4	Protein with similarity to P-type ATPase sodium pumps, member of the Na+ efflux ATPase family [Source:SGD;Acc:S000002445]
D	YDR039C	ENA2	1061	-401.7	4	P-type ATPase sodium pump, involved in Na+ efflux to allow salt tolerance; likely not involved in Li+ efflux [Source:SGD;Acc:S000002446]
D	YDR040C	ENA1	1089	-358	4	P-type ATPase sodium pump, involved in Na+ and Li+ efflux to allow salt tolerance [Source:SGD;Acc:S000002447]
D	YDR041W	RSM10	453	-91.9	4	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S10 ribosomal protein; essential for viability, unlike most other mitoribosomal proteins [Source:SGD;Acc:S000002448]
D	YDR042C	YDR042C	7	-1.6	1	Putative protein of unknown function; expression is increased in ssu72-ts69 mutant [Source:SGD;Acc:S000002449]
D	YDR043C	NRG1	170	-62.4	4	Transcriptional repressor that recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response [Source:SGD;Acc:S000002450]
D	YDR044W	HEM13	1055	-363.5	4	Coproporphyrinogen III oxidase, an oxygen requiring enzyme that catalyzes the sixth step in the heme biosynthetic pathway; transcription is repressed by oxygen and heme (via Rox1p and Hap1p) [Source:SGD;Acc:S000002451]
D	YDR045C	RPC11	341	-80.2	4	RNA polymerase III subunit C11; mediates pol III RNA cleavage activity and is important for termination of transcription; homologous to TFIIS [Source:SGD;Acc:S000002452]
D	YDR046C	BAP3	175	-94.9	4	Amino acid permease involved in the uptake of cysteine, leucine, isoleucine and valine [Source:SGD;Acc:S000002453]
D	YDR047W	HEM12	558	-316.7	4	Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda [Source:SGD;Acc:S000002454]
D	YDR048C	YDR048C	3	-2	1	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002455]
D	YDR049W	VMS1	550	-207.7	4	Component of a Cdc48p-complex involved in protein quality control; exhibits cytosolic and ER-membrane localization, with Cdc48p, during normal growth, and contributes to ER-associated degradation (ERAD) of specific substrates at a step after their u  ination; forms a mitochondrially-associated complex with Cdc48p and Npl4p under oxidative stress that is required for ubiquitin-mediated mitochondria-associated protein degradation (MAD); conserved in C. elegans and humans [Source:SGD;Acc:S000002456]
D	YDR050C	TPI1	4458	-1541.4	4	Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activi  PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease [Source:SGD;Acc:S000002457]
D	YDR051C	DET1	620	-218.2	4	Acid phosphatase involved in the non-vesicular transport of sterols in both directions between the endoplasmic reticulum and plasma membrane; deletion confers sensitivity to nickel [Source:SGD;Acc:S000002458]
D	YDR052C	DBF4	89	-96.6	4	Regulatory subunit of Cdc7p-Dbf4p kinase complex, required for Cdc7p kinase activity and initiation of DNA replication; phosphorylates the Mcm2-7 family of proteins; cell cycle regulated [Source:SGD;Acc:S000002459]
D	YDR053W	YDR053W	0	nf	1	Putative protein of unknown function; open reading frame overlaps 5' end of essential DBF4 gene encoding the regulatory subunit of the Cdc7p-Dbf4p kinase complex [Source:SGD;Acc:S000002460]
D	YDR054C	CDC34	696	-294.3	4	Ubiquitin-conjugating enzyme (E2) and catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation [Source:SGD;Acc:S000002461]
D	YDR055W	PST1	850	-301.3	4	Cell wall protein that contains a putative GPI-attachment site; secreted by regenerating protoplasts; up-regulated by activation of the cell integrity pathway, as mediated by Rlm1p; upregulated by cell wall damage via disruption of FKS1 [Source:SGD;Acc:S000002462]
D	YDR056C	YDR056C	357	-151.3	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein [Source:SGD;Acc:S000002463]
D	YDR057W	YOS9	352	-199.1	4	ER quality-control lectin; integral subunit of the HRD ligase; binds to glycans with terminal alpha-1,6 linked mannose on misfolded N-glycosylated proteins and participates in targeting proteins to ERAD; member of the OS-9 protein family [Source:SGD;Acc:S000002464]
D	YDR058C	TGL2	72	-143.6	4	Triacylglycerol lipase that is localized to the mitochondria; has lipolytic activity towards triacylglycerols and diacylglycerols when expressed in E. coli [Source:SGD;Acc:S000002465]
D	YDR059C	UBC5	931	-112.5	4	Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived, abnormal, or excess proteins, including histone H3; central component of the cellular stress response; expression is heat inducible [Source:SGD;Acc:S000002466]
D	YDR060W	MAK21	2153	-587	4	Constituent of 66S pre-ribosomal particles, required for large (60S) ribosomal subunit biogenesis; involved in nuclear export of pre-ribosomes; required for maintenance of dsRNA virus; homolog of human CAATT-binding protein [Source:SGD;Acc:S000002467]
D	YDR061W	YDR061W	571	-439.9	4	Protein with similarity to ATP-binding cassette (ABC) transporter family members; lacks predicted membrane-spanning regions; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance [Source:SGD;Acc:S000002468]
D	YDR062W	LCB2	1220	-523.4	4	Component of serine palmitoyltransferase, responsible along with Lcb1p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine [Source:SGD;Acc:S000002469]
D	YDR063W	AIM7	700	-107.7	4	Protein that interacts with Arp2/3 complex to stimulate actin filament debranching and inhibit actin nucleation; has similarity to Cof1p and also to human glia maturation factor (GMF); null mutant displays elevated mitochondrial genome loss [Source:SGD;Acc:S000002470]
D	YDR064W	RPS13	4140	-453.4	4	Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S15 and rat S13 ribosomal proteins [Source:SGD;Acc:S000002471]
D	YDR065W	RRG1	43	-51.3	4	Protein of unknown function, required for vacuolar acidification and mitochondrial genome maintenance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002472]
D	YDR066C	RTR2	37	-27.7	2	Protein of unknown function with high similarity to Rtr1p; exhibits genetic interactions with Rtr1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YDR066C is not an essential gene [Source:SGD;Acc:S000002473]
D	YDR067C	OCA6	184	-111	4	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying positive-strand RNA virus replication; null mutation confers sensitivity to tunicamycin and DTT [Source:SGD;Acc:S000002474]
D	YDR068W	DOS2	715	-283.9	4	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000002475]
D	YDR069C	DOA4	203	-206	4	Ubiquitin isopeptidase, required for recycling ubiquitin from proteasome-bound ubiquitinated intermediates, acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole [Source:SGD;Acc:S000002476]
D	YDR070C	FMP16	266	-113.2	4	Putative protein of unknown function; proposed to be involved in responding to conditions of stress; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002477]
D	YDR071C	PAA1	2355	-400.1	4	Polyamine acetyltransferase; acetylates polyamines (e.g. putrescine, spermidine, spermine) and also aralkylamines (e.g. tryptamine, phenylethylamine); may be involved in transcription and/or DNA replication [Source:SGD;Acc:S000002478]
D	YDR072C	IPT1	106	-112.5	4	Inositolphosphotransferase, involved in synthesis of mannose-(inositol-P)2-ceramide (M(IP)2C), the most abundant sphingolipid;, can mutate to resistance to the antifungals syringomycin E and DmAMP1 and to K. lactis zymocin [Source:SGD;Acc:S000002479]
D	YDR073W	SNF11	74	-97.8	4	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; interacts with a highly conserved 40-residue sequence of Snf2p [Source:SGD;Acc:S000002480]
D	YDR074W	TPS2	2184	-2547.3	4	Phosphatase subunit of the trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway [Source:SGD;Acc:S000002481]
D	YDR075W	PPH3	104	-99.1	4	Catalytic subunit of protein phosphatase PP4 complex; active complex is composed of Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also the gene   sion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; involved in activation of Gln3p to alleviate nitrogen catabolite repression; Pph3p and Psy2p localize to foci on meiotic chromosomes [Source:SGD;Acc:S000002482]
D	YDR076W	RAD55	25	-36	2	Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p [Source:SGD;Acc:S000002483]
D	YDR077W	SED1	112	-30.6	4	Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites [Source:SGD;Acc:S000002484]
D	YDR078C	SHU2	39	-16.8	2	Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function [Source:SGD;Acc:S000002485]
D	YDR079C-A	TFB5	145	-44	4	Component of the RNA polymerase II general transcription and DNA repair factor TFIIH; involved in transcription initiation and in nucleotide-excision repair; homolog of Chlamydomonas reinhardtii REX1-S protein involved in DNA repair [Source:SGD;Acc:S000007603]
D	YDR079W	PET100	101	-77.6	4	Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme [Source:SGD;Acc:S000002486]
D	YDR080W	VPS41	370	-304.7	4	Vacuolar membrane protein that is a subunit of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex; essential for membrane docking and fusion at the Golgi-to-endosome and endosome-to-vacuole stages of protein transport [Source:SGD;Acc:S000002487]
D	YDR081C	PDC2	506	-230.1	4	Putative transcription factor for thiamine-regulated genes; required for expression of the two isoforms of pyruvate decarboxylase (PDC1 and PDC5) along with thiamine biosynthetic genes; mutant fails to grow on 2% glucose and thus is scored as inviab  er standard conditions [Source:SGD;Acc:S000002488]
D	YDR082W	STN1	17	-20.2	2	Telomere end-binding and capping protein, plays a key role with Pol12p in linking telomerase action with completion of lagging strand synthesis, and in a regulatory step required for telomere capping [Source:SGD;Acc:S000002489]
D	YDR083W	RRP8	724	-265.5	4	Nucleolar protein involved in rRNA processing, pre-rRNA cleavage at site A2; also involved in telomere maintenance; mutation is synthetically lethal with a gar1 mutation [Source:SGD;Acc:S000002490]
D	YDR084C	TVP23	243	-85.9	4	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000002491]
D	YDR085C	AFR1	60	-39.9	4	Protein required for pheromone-induced projection (shmoo) formation; regulates septin architecture during mating; has an RVXF motif that mediates targeting of Glc7p to mating projections; interacts with Cdc12p [Source:SGD;Acc:S000002492]
D	YDR086C	SSS1	1265	-94	4	Subunit of the Sec61p translocation complex (Sec61p-Sss1p-Sbh1p) that forms a channel for passage of secretory proteins through the endoplasmic reticulum membrane, and of the Ssh1p complex (Ssh1p-Sbh2p-Sss1p); interacts with Ost4p and Wbp1p [Source:SGD;Acc:S000002493]
D	YDR087C	RRP1	1093	-210.2	4	Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles [Source:SGD;Acc:S000002494]
D	YDR088C	SLU7	267	-157.2	4	RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain [Source:SGD;Acc:S000002495]
D	YDR089W	YDR089W	717	-403.5	4	Protein of unknown function; deletion confers resistance to Nickel [Source:SGD;Acc:S000002496]
D	YDR090C	YDR090C	72	-27.1	4	Putative protein of unknown function [Source:SGD;Acc:S000002497]
D	YDR091C	RLI1	2529	-599.4	4	Essential iron-sulfur protein required for ribosome biogenesis and translation initiation and termination; facilitates binding of a multifactor complex (MFC) of initiation factors to the small ribosomal subunit; predicted ABC family ATPase [Source:SGD;Acc:S000002498]
D	YDR092W	UBC13	740	-120.3	4	Ubiquitin-conjugating enzyme involved in the error-free DNA postreplication repair pathway; interacts with Mms2p to assemble ubiquitin chains at the Ub Lys-63 residue; DNA damage triggers redistribution from the cytoplasm to the nucleus [Source:SGD;Acc:S000002499]
D	YDR093W	DNF2	840	-560.9	4	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase [Source:SGD;Acc:S000002500]
D	YDR094W	YDR094W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2 [Source:SGD;Acc:S000002501]
D	YDR095C	YDR095C	7	-2.2	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002502]
D	YDR096W	GIS1	700	-415.1	4	JmjC domain-containing histone demethylase and transcription factor; involved in expression of genes during nutrient limitation; negatively regulates DPP1 and PHR1; activity is modulated by limited proteasome-mediated proteolysis; has a JmjC and a J  main in the N-terminal region that interact, promoting Gis1p stability and proper transcriptional activity; contains transactivating domains TAD1 and TAD2 downstream of the Jmj domains and a C-terminal DNA binding domain [Source:SGD;Acc:S000002503]
D	YDR097C	MSH6	1257	-538.9	4	Protein required for mismatch repair in mitosis and meiosis, forms a complex with Msh2p to repair both single-base & insertion-deletion mispairs; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000002504]
D	YDR098C	GRX3	1426	-171.5	4	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage [Source:SGD;Acc:S000002505]
D	YDR098C-A	YDR098C-A	4610	-1602.6	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007390]
D	YDR098C-B	YDR098C-B	4910	-2216.3	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007391]
D	YDR099W	BMH2	4451	-844.3	4	14-3-3 protein, minor isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling [Source:SGD;Acc:S000002506]
D	YDR100W	TVP15	90	-35.4	4	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p [Source:SGD;Acc:S000002507]
D	YDR101C	ARX1	1940	-491.2	4	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex [Source:SGD;Acc:S000002508]
D	YDR102C	YDR102C	4	-2.2	2	Dubious open reading frame; homozygous diploid deletion strain exhibits high budding index [Source:SGD;Acc:S000002509]
D	YDR103W	STE5	361	-115.4	4	Pheromone-response scaffold protein that controls the mating decision; binds Ste11p, Ste7p, and Fus3p kinases, forming a MAPK cascade complex that interacts with the plasma membrane and Ste4p-Ste18p; allosteric activator of Fus3p [Source:SGD;Acc:S000002510]
D	YDR104C	SPO71	88	-146.1	4	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis [Source:SGD;Acc:S000002511]
D	YDR105C	TMS1	18	-81.2	4	Vacuolar membrane protein of unknown function that is conserved in mammals; predicted to contain eleven transmembrane helices; interacts with Pdr5p, a protein involved in multidrug resistance [Source:SGD;Acc:S000002512]
D	YDR106W	ARP10	10	-19.7	2	Component of the dynactin complex, localized to the pointed end of the Arp1p filament; may regulate membrane association of the complex [Source:SGD;Acc:S000002513]
D	YDR107C	TMN2	431	-190.9	4	Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn3p; member of the evolutionarily conserved Transmembrane Nine family of proteins with nine membrane-spanning segments [Source:SGD;Acc:S000002514]
D	YDR108W	TRS85	214	-212.9	4	Subunit of TRAPPIII (transport protein particle), a multimeric guanine nucleotide-exchange factor for Ypt1p, required for membrane expansion during autophagy and the CVT pathway; directs Ypt1p to the PAS; late post-replication meiotic role [Source:SGD;Acc:S000002515]
D	YDR109C	YDR109C	236	-294.7	4	Putative kinase [Source:SGD;Acc:S000002516]
D	YDR110W	FOB1	295	-192.7	4	Nucleolar protein that binds the rDNA replication fork barrier (RFB) site; required for replication fork blocking, recombinational hotspot activity, condensin recruitment to RFB and rDNA repeat segregation; related to retroviral integrases [Source:SGD;Acc:S000002517]
D	YDR111C	ALT2	177	-177.6	4	Putative alanine transaminase (glutamic pyruvic transaminase) [Source:SGD;Acc:S000002518]
D	YDR112W	IRC2	4	-2.9	2	Dubious open reading frame, unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR111C; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000002519]
D	YDR113C	PDS1	107	-102.2	4	Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation [Source:SGD;Acc:S000002520]
D	YDR114C	YDR114C	3	-1.2	1	Putative protein of unknown function; deletion mutant exhibits poor growth at elevated pH and calcium [Source:SGD;Acc:S000002521]
D	YDR115W	YDR115W	70	-25.5	4	Putative mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L34 ribosomal protein; required for respiratory growth, as are most mitochondrial ribosomal proteins [Source:SGD;Acc:S000002522]
D	YDR116C	MRPL1	637	-256.7	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000002523]
D	YDR117C	TMA64	849	-281.3	4	Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity [Source:SGD;Acc:S000002524]
D	YDR118W	APC4	116	-490.6	4	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain o  APC/C, based on structural analysis [Source:SGD;Acc:S000002525]
D	YDR118W-A	YDR118W-A	1	0	1	Dubious open reading frame; identified using a combination of expression profiling and mass spectrometry [Source:SGD;Acc:S000028820]
D	YDR119W	VBA4	719	-222.6	4	Protein of unknown function with proposed role as a basic amino acid permease based on phylogeny; GFP-fusion protein localizes to vacuolar membrane; physical interaction with Atg27p suggests a possible role in autophagy; non-essential gene [Source:SGD;Acc:S000002526]
D	YDR119W-A	COX26	130	-77.7	4	Putative protein of unknown function; may interact with respiratory chain complexes III (ubiquinol-cytochrome c reductase) or IV (cytochrome c oxidase) [Source:SGD;Acc:S000113555]
D	YDR120C	TRM1	1639	-534.9	4	tRNA methyltransferase; two forms of the protein are made by alternative translation starts; localizes to both the nucleus and mitochondrion to produce the modified base N2,N2-dimethylguanosine in tRNAs in both compartments [Source:SGD;Acc:S000002527]
D	YDR121W	DPB4	589	-203.7	4	Shared subunit of DNA polymerase (II) epsilon and of ISW2/yCHRAC chromatin accessibility complex; involved in both chromosomal DNA replication and in inheritance of telomeric silencing [Source:SGD;Acc:S000002528]
D	YDR122W	KIN1	1096	-1867	4	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p [Source:SGD;Acc:S000002529]
D	YDR123C	INO2	84	-50.8	4	Component of the heteromeric Ino2p/Ino4p basic helix-loop-helix transcription activator that binds inositol/choline-responsive elements (ICREs), required for derepression of phospholipid biosynthetic genes in response to inositol depletion [Source:SGD;Acc:S000002530]
D	YDR124W	YDR124W	12	-2.4	2	Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor [Source:SGD;Acc:S000002531]
D	YDR125C	ECM18	22	-83.3	3	Protein of unknown function, similar to Rlp24p [Source:SGD;Acc:S000002532]
D	YDR126W	SWF1	25	-14.9	2	Palmitoyltransferase that acts on transmembrane proteins, including the SNAREs Snc1p, Syn8p, Tlg1p and likely all SNAREs; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; may have a role in vacuole fusion [Source:SGD;Acc:S000002533]
D	YDR127W	ARO1	3290	-2041	4	Pentafunctional arom protein, catalyzes steps 2 through 6 in the biosynthesis of chorismate, which is a precursor to aromatic amino acids [Source:SGD;Acc:S000002534]
D	YDR128W	MTC5	345	-308.1	4	Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; has N-terminal WD-40 repeats and a C-terminal RING motif; mtc5 is synthetically sick with cdc13-1 [Source:SGD;Acc:S000002535]
D	YDR129C	SAC6	3074	-1598.6	4	Fimbrin, actin-bundling protein; cooperates with Scp1p (calponin/transgelin) in the organization and maintenance of the actin cytoskeleton [Source:SGD;Acc:S000002536]
D	YDR130C	FIN1	126	-91.8	4	Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in mother and daughter cells; localization cell-cycle dependent; involved in Glc7p localization and regulation [Source:SGD;Acc:S000002537]
D	YDR131C	YDR131C	55	-167.4	4	F-box protein, substrate-specific adaptor subunit that recruits substrates to a core ubiquitination complex [Source:SGD;Acc:S000002538]
D	YDR132C	YDR132C	69	-80.2	4	Putative protein of unknown function [Source:SGD;Acc:S000002539]
D	YDR133C	YDR133C	16	-11.3	3	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YDR134C [Source:SGD;Acc:S000002540]
D	YDR135C	YCF1	1655	-679.8	4	Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione;   r to human cystic fibrosis protein CFTR [Source:SGD;Acc:S000002542]
D	YDR136C	VPS61	20	-2.4	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 4% of ORF overlaps the verified gene RGP1; deletion causes a vacuolar protein sorting defect [Source:SGD;Acc:S000002543]
D	YDR137W	RGP1	258	-159.5	4	Subunit of a Golgi membrane exchange factor (Ric1p-Rgp1p) that catalyzes nucleotide exchange on Ypt6p [Source:SGD;Acc:S000002544]
D	YDR138W	HPR1	563	-500.4	4	Subunit of THO/TREX complexes that couple transcription elongation with mitotic recombination and with mRNA metabolism and export, subunit of an RNA Pol II complex; regulates lifespan; involved in telomere maintenance; similar to Top1p [Source:SGD;Acc:S000002545]
D	YDR139C	RUB1	134	-91.6	4	Ubiquitin-like protein with similarity to mammalian NEDD8; conjugation (neddylation) substrates include the cullins Cdc53p, Rtt101p, and Cul3p; activated by Ula1p and Uba3p (E1 enzyme pair); conjugation mediated by Ubc12p (E2 enzyme) [Source:SGD;Acc:S000002546]
D	YDR140W	MTQ2	163	-51.5	4	S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC [Source:SGD;Acc:S000002547]
D	YDR141C	DOP1	1138	-839.5	4	Golgi-localized, leucine-zipper domain containing protein; involved in endosome to Golgi transport, organization of the ER, establishing cell polarity, and morphogenesis; detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002548]
D	YDR142C	PEX7	126	-77.2	4	Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP) [Source:SGD;Acc:S000002549]
D	YDR143C	SAN1	581	-229.4	4	Ubiquitin-protein ligase; involved in the proteasome-dependent degradation of aberrant nuclear proteins; targets substrates with regions of exposed hydrophobicity containing 5 or more contiguous hydrophobic residues; contains intrinsically disordere  ons that contribute to substrate recognition [Source:SGD;Acc:S000002550]
D	YDR144C	MKC7	377	-131.6	4	GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p [Source:SGD;Acc:S000002551]
D	YDR145W	TAF12	1423	-1435.9	4	Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A [Source:SGD;Acc:S000002552]
D	YDR146C	SWI5	298	-138.5	4	Transcription factor that activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; localization to the nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase [Source:SGD;Acc:S000002553]
D	YDR147W	EKI1	177	-230	4	Ethanolamine kinase, primarily responsible for phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway; exhibits some choline kinase activity, thus contributing to phosphatidylcholine synthesis via the CDP-choline pathway [Source:SGD;Acc:S000002554]
D	YDR148C	KGD2	1841	-673.2	4	Dihydrolipoyl transsuccinylase, component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes the oxidative decarboxylation of alpha-ketoglutarate to succinyl-CoA in the TCA cycle; phosphorylated [Source:SGD;Acc:S000002555]
D	YDR149C	YDR149C	3	-1.2	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth [Source:SGD;Acc:S000002556]
D	YDR150W	NUM1	2295	-1804.4	4	Protein required for nuclear migration, localizes to the mother cell cortex and the bud tip; may mediate interactions of dynein and cytoplasmic microtubules with the cell cortex [Source:SGD;Acc:S000002557]
D	YDR151C	CTH1	25	-29.5	4	Member of the CCCH zinc finger family; has similarity to mammalian Tis11 protein, which activates transcription and also has a role in mRNA degradation; may function with Tis11p in iron homeostasis [Source:SGD;Acc:S000002558]
D	YDR152W	GIR2	690	-165.4	4	Highly-acidic cytoplasmic RWD domain-containing protein of unknown function; forms a complex with Rbg2p; interacts with Rbg1p and Gcn1p; associates with translating ribosomes; putative intrinsically unstructured protein [Source:SGD;Acc:S000002559]
D	YDR153C	ENT5	1016	-384.3	4	Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin [Source:SGD;Acc:S000002560]
D	YDR154C	YDR154C	1	-2.4	2	Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein [Source:SGD;Acc:S000002561]
D	YDR155C	CPR1	4031	-630.2	4	Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A [Source:SGD;Acc:S000002562]
D	YDR156W	RPA14	567	-81.5	4	RNA polymerase I subunit A14 [Source:SGD;Acc:S000002563]
D	YDR157W	YDR157W	3	-1.7	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002564]
D	YDR158W	HOM2	3161	-807.1	4	Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis [Source:SGD;Acc:S000002565]
D	YDR159W	SAC3	559	-1951	4	Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional t  ng of active genes to the nuclear periphery and to non-nascent mRNP; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay [Source:SGD;Acc:S000002566]
D	YDR160W	SSY1	25	-14.7	2	Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes [Source:SGD;Acc:S000002567]
D	YDR161W	YDR161W	957	-312	4	Putative protein of unknown function; non-essential gene; proposed function in rRNA and ribosome biosynthesis based on transcriptional co-regulation; genetic interactions suggest a role in ER-associated protein degradation (ERAD) [Source:SGD;Acc:S000002568]
D	YDR162C	NBP2	627	-223	4	Protein involved in the HOG (high osmolarity glycerol) pathway, negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex, found in the nucleus and cytoplasm, contains an SH3 domain that binds Pbs2p [Source:SGD;Acc:S000002569]
D	YDR163W	CWC15	227	-124.2	4	Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p [Source:SGD;Acc:S000002570]
D	YDR164C	SEC1	932	-536.6	4	Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function [Source:SGD;Acc:S000002571]
D	YDR165W	TRM82	1394	-433.1	4	Catalytic subunit of a tRNA methyltransferase complex; Trm8p and Trm82p comprise an enzyme that catalyzes a methyl-transfer from S-adenosyl-l-methionine to the N(7) atom of guanine at position 46 in tRNA; Trm8 lacks catalytic activity if not bound t  2p [Source:SGD;Acc:S000002572]
D	YDR166C	SEC5	474	-533.6	4	Essential 107kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis [Source:SGD;Acc:S000002573]
D	YDR167W	TAF10	968	-534.1	4	Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification [Source:SGD;Acc:S000002574]
D	YDR168W	CDC37	1805	-550.5	4	Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding [Source:SGD;Acc:S000002575]
D	YDR169C	STB3	848	-346.7	4	Ribosomal RNA processing element (RRPE)-binding protein involved in the glucose-induced transition from quiescence to growth; restricted to nucleus in quiescent cells, released into cytoplasm after glucose repletion; binds Sin3p [Source:SGD;Acc:S000002576]
D	YDR169C-A	YDR169C-A	5	-1.4	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028538]
D	YDR170C	SEC7	2307	-1682.1	4	Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles [Source:SGD;Acc:S000002577]
D	YDR170W-A	YDR170W-A	2971	-541.7	4	Retrotransposon TYA Gag gene; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag; YDR170W-A is part of a mutant retrotransposon [Source:SGD;Acc:S000007227]
D	YDR171W	HSP42	1994	-432.3	4	Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock [Source:SGD;Acc:S000002578]
D	YDR172W	SUP35	2944	-880.1	4	Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype [Source:SGD;Acc:S000002579]
D	YDR173C	ARG82	439	-134.8	4	Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes [Source:SGD;Acc:S000002580]
D	YDR174W	HMO1	2026	-408.6	4	Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase [Source:SGD;Acc:S000002581]
D	YDR175C	RSM24	555	-164.6	4	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000002582]
D	YDR176W	NGG1	647	-1071.3	4	Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex [Source:SGD;Acc:S000002583]
D	YDR177W	UBC1	1724	-188.2	4	Ubiquitin-conjugating enzyme that mediates selective degradation of short-lived and abnormal proteins; plays a role in vesicle biogenesis and ER-associated protein degradation (ERAD); component of the cellular stress response [Source:SGD;Acc:S000002584]
D	YDR178W	SDH4	291	-203	4	Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain [Source:SGD;Acc:S000002585]
D	YDR179C	CSN9	59	-37.3	4	Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling [Source:SGD;Acc:S000002586]
D	YDR179W-A	YDR179W-A	28	-75.8	4	Putative protein of unknown function [Source:SGD;Acc:S000002587]
D	YDR180W	SCC2	238	-2817.9	4	Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin [Source:SGD;Acc:S000002588]
D	YDR181C	SAS4	256	-187	4	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p [Source:SGD;Acc:S000002589]
D	YDR182W	CDC1	639	-284.3	4	Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution [Source:SGD;Acc:S000002590]
D	YDR182W-A	YDR182W-A	5	-3.3	2	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028539]
D	YDR183C-A	YDR183C-A	3	-1.3	1	Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028540]
D	YDR183W	PLP1	150	-127.8	4	Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators [Source:SGD;Acc:S000002591]
D	YDR184C	ATC1	70	-61.6	4	Nuclear protein, possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern [Source:SGD;Acc:S000002592]
D	YDR185C	UPS3	27	-23.2	2	Mitochondrial protein of unknown function; similar to Ups1p and Ups2p which are involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null is viable but interacts synthetically with ups1 and ups2 mutations [Source:SGD;Acc:S000002593]
D	YDR186C	YDR186C	570	-186.5	4	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000002594]
D	YDR187C	YDR187C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W [Source:SGD;Acc:S000002595]
D	YDR188W	CCT6	2150	-602.5	4	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif [Source:SGD;Acc:S000002596]
D	YDR189W	SLY1	1334	-624.6	4	Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex [Source:SGD;Acc:S000002597]
D	YDR190C	RVB1	2602	-3007.6	4	Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as pontin; member of the RUVB-like protein family [Source:SGD;Acc:S000002598]
D	YDR191W	HST4	27	-13.8	3	Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism [Source:SGD;Acc:S000002599]
D	YDR192C	NUP42	510	-221.9	4	Subunit of the nuclear pore complex (NPC) that localizes exclusively to the cytoplasmic side; involved in RNA export, most likely at a terminal step; interacts with Gle1p [Source:SGD;Acc:S000002600]
D	YDR193W	YDR193W	8	-4	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002601]
D	YDR194C	MSS116	1391	-408.6	4	DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing [Source:SGD;Acc:S000002602]
D	YDR194W-A	YDR194W-A	8	-2.2	2	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028541]
D	YDR195W	REF2	583	-302.1	4	RNA-binding protein involved in the cleavage step of mRNA 3'-end formation prior to polyadenylation, and in snoRNA maturation; part of holo-CPF subcomplex APT, which associates with 3'-ends of snoRNA- and mRNA-encoding genes [Source:SGD;Acc:S000002603]
D	YDR196C	CAB5	288	-138.9	4	Probable dephospho-CoA kinase (DPCK) that catalyzes the last step in coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaE (encoding DPCK); detected in purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002604]
D	YDR197W	CBS2	78	-78.2	4	Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader [Source:SGD;Acc:S000002605]
D	YDR198C	RKM2	102	-222.4	4	Ribosomal protein lysine methyltransferase, responsible for trimethylation of the lysine residue at position 3 of Rpl12Ap and Rpl12Bp [Source:SGD;Acc:S000002606]
D	YDR199W	YDR199W	2	-1.7	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity [Source:SGD;Acc:S000002607]
D	YDR200C	VPS64	244	-151.6	4	Protein required for cytoplasm to vacuole targeting of proteins; forms a complex with Far3p and Far7p to Far11p involved in recovery from pheromone-induced cell cycle arrest; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000002608]
D	YDR201W	SPC19	375	-104.2	4	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body [Source:SGD;Acc:S000002609]
D	YDR202C	RAV2	202	-156.9	4	Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme [Source:SGD;Acc:S000002610]
D	YDR203W	YDR203W	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002611]
D	YDR204W	COQ4	286	-133.2	4	Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex [Source:SGD;Acc:S000002612]
D	YDR205W	MSC2	153	-119	4	Member of the cation diffusion facilitator family, localizes to the endoplasmic reticulum and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids [Source:SGD;Acc:S000002613]
D	YDR206W	EBS1	240	-297.6	4	Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors [Source:SGD;Acc:S000002614]
D	YDR207C	UME6	691	-261.7	4	Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p [Source:SGD;Acc:S000002615]
D	YDR208W	MSS4	463	-1223.1	4	Phosphatidylinositol-4-phosphate 5-kinase, involved in actin cytoskeleton organization and cell morphogenesis; multicopy suppressor of stt4 mutation [Source:SGD;Acc:S000002616]
D	YDR209C	YDR209C	323	-12.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W. [Source:SGD;Acc:S000002617]
D	YDR210C-C	YDR210C-C	4415	-1558.2	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007409]
D	YDR210C-D	YDR210C-D	4801	-2185.6	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007410]
D	YDR210W	YDR210W	15	-156	4	Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000002618]
D	YDR210W-A	YDR210W-A	1018	-315.9	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007392]
D	YDR210W-B	YDR210W-B	2371	-742.1	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007393]
D	YDR211W	GCD6	1826	-720.4	4	Catalytic epsilon subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression [Source:SGD;Acc:S000002619]
D	YDR212W	TCP1	2562	-885.9	4	Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein [Source:SGD;Acc:S000002620]
D	YDR213W	UPC2	250	-123.4	4	Sterol regulatory element binding protein, induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; Ecm22p homolog; relocates from intracellular membranes to perinuclear foci on sterol depletion [Source:SGD;Acc:S000002621]
D	YDR214W	AHA1	1850	-598.6	4	Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock [Source:SGD;Acc:S000002622]
D	YDR215C	YDR215C	2	-1.9	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein [Source:SGD;Acc:S000002623]
D	YDR216W	ADR1	762	-2110.1	4	Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization [Source:SGD;Acc:S000002624]
D	YDR217C	RAD9	462	-236.2	4	DNA damage-dependent checkpoint protein, required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; potential Cdc28p substrate [Source:SGD;Acc:S000002625]
D	YDR218C	SPR28	12	-6	2	Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; meiotic septin expressed at high levels during meiotic divisions and ascospore formation [Source:SGD;Acc:S000002626]
D	YDR219C	MFB1	272	-264.4	4	Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding [Source:SGD;Acc:S000002627]
D	YDR220C	YDR220C	0	nf	1	Dubious open reading frame, null mutant exhibits synthetic phenotype with alpha-synuclein [Source:SGD;Acc:S000002628]
D	YDR221W	GTB1	421	-302.4	4	Glucosidase II beta subunit, forms a complex with alpha subunit Rot2p, involved in removal of two glucose residues from N-linked glycans during glycoprotein biogenesis in the ER [Source:SGD;Acc:S000002629]
D	YDR222W	YDR222W	166	-125.4	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000002630]
D	YDR223W	CRF1	12	-7.9	2	Transcriptional corepressor involved in repression of ribosomal protein (RP) gene transcription via the TOR signaling pathway which promotes accumulation of Crf1p in the nucleus; role in repression of RP genes varies by strain [Source:SGD;Acc:S000002631]
D	YDR224C	HTB1	3698	-391.7	4	Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation [Source:SGD;Acc:S000002632]
D	YDR225W	HTA1	2848	-485.5	4	Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p [Source:SGD;Acc:S000002633]
D	YDR226W	ADK1	3229	-588.3	4	Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence [Source:SGD;Acc:S000002634]
D	YDR227W	SIR4	590	-1661	4	Silent information regulator that, together with SIR2 and SIR3, is involved in assembly of silent chromatin domains at telomeres and the silent mating-type loci; potentially phosphorylated by Cdc28p; some alleles of SIR4 prolong lifespan [Source:SGD;Acc:S000002635]
D	YDR228C	PCF11	504	-388.7	4	mRNA 3' end processing factor, essential component of cleavage and polyadenylation factor IA (CF IA), involved in pre-mRNA 3' end processing and in transcription termination; binds C-terminal domain of largest subunit of RNA pol II (Rpo21p); require  gene looping [Source:SGD;Acc:S000002636]
D	YDR229W	IVY1	783	-282.1	4	Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase [Source:SGD;Acc:S000002637]
D	YDR230W	YDR230W	8	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20 [Source:SGD;Acc:S000002638]
D	YDR231C	COX20	525	-141.6	4	Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase [Source:SGD;Acc:S000002639]
D	YDR232W	HEM1	1230	-414.5	4	5-aminolevulinate synthase, catalyzes the first step in the heme biosynthetic pathway; an N-terminal signal sequence is required for localization to the mitochondrial matrix; expression is regulated by Hap2p-Hap3p [Source:SGD;Acc:S000002640]
D	YDR233C	RTN1	3237	-660	4	ER membrane protein that interacts with Sey1p to maintain ER morphology; interacts with exocyst subunit Sec6p, with Yip3p, and with Sbh1p; null mutant has an altered ER morphology; member of the RTNLA (reticulon-like A) subfamily [Source:SGD;Acc:S000002641]
D	YDR234W	LYS4	1679	-719.8	4	Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway [Source:SGD;Acc:S000002642]
D	YDR235W	PRP42	119	-370.4	4	U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats [Source:SGD;Acc:S000002643]
D	YDR236C	FMN1	383	-99.8	4	Riboflavin kinase, phosphorylates riboflavin to form riboflavin monophosphate (FMN), which is a necessary cofactor for many enzymes; localizes to microsomes and to the mitochondrial inner membrane [Source:SGD;Acc:S000002644]
D	YDR237W	MRPL7	569	-137.2	4	Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein [Source:SGD;Acc:S000002645]
D	YDR238C	SEC26	2645	-1127.6	4	Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP) [Source:SGD;Acc:S000002646]
D	YDR239C	YDR239C	496	-417.1	4	Protein of unknown function that may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000002647]
D	YDR240C	SNU56	203	-334.3	4	Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart; interacts with mRNA in commitment complex [Source:SGD;Acc:S000002648]
D	YDR241W	BUD26	8	-4	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 1% of ORF overlaps the verified gene SNU56; diploid mutant displays a weak budding pattern phenotype in a systematic assay [Source:SGD;Acc:S000002649]
D	YDR242W	AMD2	24	-50	3	Putative amidase [Source:SGD;Acc:S000002650]
D	YDR243C	PRP28	390	-186.3	4	RNA helicase in the DEAD-box family, involved in RNA isomerization at the 5' splice site [Source:SGD;Acc:S000002651]
D	YDR244W	PEX5	383	-374.6	4	Peroxisomal membrane signal receptor for the C-terminal tripeptide signal sequence (PTS1) of peroxisomal matrix proteins, required for peroxisomal matrix protein import; also proposed to have PTS1-receptor independent functions [Source:SGD;Acc:S000002652]
D	YDR245W	MNN10	955	-286.4	4	Subunit of a Golgi mannosyltransferase complex also containing Anp1p, Mnn9p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; membrane protein of the mannosyltransferase family [Source:SGD;Acc:S000002653]
D	YDR246W	TRS23	264	-120.6	4	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic; human homolog is TRAPPC4 [Source:SGD;Acc:S000002654]
D	YDR246W-A	YDR246W-A	1	-1.5	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028542]
D	YDR247W	VHS1	61	-892.2	4	Cytoplasmic serine/threonine protein kinase; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; homolog of Sks1p [Source:SGD;Acc:S000002655]
D	YDR248C	YDR248C	313	-136	4	Putative protein of unknown function; sequence similarity to bacterial and human gluconokinase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; upregulated by deletion of the RNAP-II associated factor, PAF1 [Source:SGD;Acc:S000002656]
D	YDR249C	YDR249C	18	-12.6	2	Putative protein of unknown function [Source:SGD;Acc:S000002657]
D	YDR250C	YDR250C	1	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000002658]
D	YDR251W	PAM1	1153	-1737.1	4	Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype [Source:SGD;Acc:S000002659]
D	YDR252W	BTT1	60	-34.2	4	Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3 [Source:SGD;Acc:S000002660]
D	YDR253C	MET32	22	-19.3	3	Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met31p [Source:SGD;Acc:S000002661]
D	YDR254W	CHL4	56	-51.3	4	Outer kinetochore protein required for chromosome stability; involved in new kinetochore assembly and sister chromatid cohesion; peripheral component of the Ctf19 kinetochore subcomplex that interacts with Ctf19p, Ctf3p, Iml3p and Mif2p [Source:SGD;Acc:S000002662]
D	YDR255C	RMD5	218	-463.4	4	Conserved protein that has an E3-like ubiquitin ligase activity necessary for polyubiquitination and degradation of the gluconeogenic enzyme fructose-1,6-bisphosphatase; also required for sporulation; has a degenerate RING finger domain [Source:SGD;Acc:S000002663]
D	YDR256C	CTA1	309	-354.5	4	Catalase A, breaks down hydrogen peroxide in the peroxisomal matrix formed by acyl-CoA oxidase (Pox1p) during fatty acid beta-oxidation [Source:SGD;Acc:S000002664]
D	YDR257C	RKM4	383	-230	4	Ribosomal lysine methyltransferase specific for monomethylation of Rpl42ap and Rpl42bp (lysine 55); nuclear SET-domain containing protein [Source:SGD;Acc:S000002665]
D	YDR258C	HSP78	1873	-962.4	4	Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates [Source:SGD;Acc:S000002666]
D	YDR259C	YAP6	53	-34.5	3	Basic leucine zipper (bZIP) transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; overexpression increases sodium and lithium tolerance; computational analysis suggests a role in regulation of expre  of genes involved in carbohydrate metabolism [Source:SGD;Acc:S000002667]
D	YDR260C	SWM1	41	-44.2	4	Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation [Source:SGD;Acc:S000002668]
D	YDR261C	EXG2	436	-191.3	4	Exo-1,3-beta-glucanase, involved in cell wall beta-glucan assembly; may be anchored to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor [Source:SGD;Acc:S000002669]
D	YDR261C-C	YDR261C-C	4708	-1803.9	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; in YDRCTY1-3 TYB is mutant and probably non-functional [Source:SGD;Acc:S000007394]
D	YDR261C-D	YDR261C-D	5016	-2483.9	4	Retrotransposon TYA Gag and TYB Pol genes; in YDRCTY1-3 TYB is mutant and probably non-functional [Source:SGD;Acc:S000007395]
D	YDR261W-A	YDR261W-A	1046	-397	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007396]
D	YDR261W-B	YDR261W-B	2229	-743.9	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007397]
D	YDR262W	YDR262W	327	-260	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment [Source:SGD;Acc:S000002670]
D	YDR263C	DIN7	21	-9.4	2	Mitochondrial nuclease functioning in DNA repair and replication, modulates the stability of the mitochondrial genome, induced by exposure to mutagens, also induced during meiosis at a time nearly coincident with commitment to recombination [Source:SGD;Acc:S000002671]
D	YDR264C	AKR1	1010	-252.7	4	Palmitoyl transferase involved in protein palmitoylation; acts as a negative regulator of pheromone response pathway; required for endocytosis of pheromone receptors; involved in cell shape control; contains ankyrin repeats [Source:SGD;Acc:S000002672]
D	YDR265W	PEX10	161	-212.8	4	Peroxisomal membrane E3 ubiquitin ligase, required for for Ubc4p-dependent Pex5p ubiquitination and peroxisomal matrix protein import; contains zinc-binding RING domain; mutations in human homolog cause various peroxisomal disorders [Source:SGD;Acc:S000002673]
D	YDR266C	HEL2	864	-335.2	4	Protein of unknown function that may interact with ribosomes, based on co-purification experiments;green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; contains a RING finger domain [Source:SGD;Acc:S000002674]
D	YDR267C	CIA1	376	-139.6	4	WD40 repeat protein involved in assembly of cytosolic and nuclear iron-sulfur proteins; similar to the human Ciao1 protein; YDR267C is an essential gene [Source:SGD;Acc:S000002675]
D	YDR268W	MSW1	398	-202.7	4	Mitochondrial tryptophanyl-tRNA synthetase [Source:SGD;Acc:S000002676]
D	YDR269C	YDR269C	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002677]
D	YDR270W	CCC2	124	-261.8	4	Cu(+2)-transporting P-type ATPase, required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases [Source:SGD;Acc:S000002678]
D	YDR271C	YDR271C	6	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W [Source:SGD;Acc:S000002679]
D	YDR272W	GLO2	1165	-242.9	4	Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate [Source:SGD;Acc:S000002680]
D	YDR273W	DON1	35	-33.3	3	Meiosis-specific component of the spindle pole body, part of the leading edge protein (LEP) coat, forms a ring-like structure at the leading edge of the prospore membrane during meiosis II [Source:SGD;Acc:S000002681]
D	YDR274C	YDR274C	3	-1.4	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002682]
D	YDR275W	BSC2	32	-50.8	4	Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression [Source:SGD;Acc:S000002683]
D	YDR276C	PMP3	14	-27	4	Small plasma membrane protein related to a family of plant polypeptides that are overexpressed under high salt concentration or low temperature, not essential for viability, deletion causes hyperpolarization of the plasma membrane potential [Source:SGD;Acc:S000002684]
D	YDR277C	MTH1	36	-30.8	4	Negative regulator of the glucose-sensing signal transduction pathway, required for repression of transcription by Rgt1p; interacts with Rgt1p and the Snf3p and Rgt2p glucose sensors; phosphorylated by Yck1p, triggering Mth1p degradation [Source:SGD;Acc:S000002685]
D	YDR278C	YDR278C	3	-1.7	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002686]
D	YDR279W	RNH202	259	-124.8	4	Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS2 that causes Aicardi-Goutieres syndrome [Source:SGD;Acc:S000002687]
D	YDR280W	RRP45	651	-454.2	4	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp45p (PM/SCL-75, EXOSC9) [Source:SGD;Acc:S000002688]
D	YDR281C	PHM6	5	-2.3	2	Protein of unknown function, expression is regulated by phosphate levels [Source:SGD;Acc:S000002689]
D	YDR282C	YDR282C	64	-49.9	4	Putative protein of unknown function [Source:SGD;Acc:S000002690]
D	YDR283C	GCN2	580	-3082.1	4	Protein kinase, phosphorylates the alpha-subunit of translation initiation factor eIF2 (Sui2p) in response to starvation; activated by uncharged tRNAs and the Gcn1p-Gcn20p complex; contributes to DNA damage checkpoint control [Source:SGD;Acc:S000002691]
D	YDR284C	DPP1	429	-122.4	4	Diacylglycerol pyrophosphate (DGPP) phosphatase, zinc-regulated vacuolar membrane-associated lipid phosphatase, dephosphorylates DGPP to phosphatidate (PA) and Pi, then PA to diacylglycerol; involved in lipid signaling and cell metabolism [Source:SGD;Acc:S000002692]
D	YDR285W	ZIP1	74	-1462.5	4	Transverse filament protein of the synaptonemal complex; required for normal levels of meiotic recombination and pairing between homologous chromosome during meiosis; potential Cdc28p substrate [Source:SGD;Acc:S000002693]
D	YDR286C	YDR286C	101	-45.3	4	Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site [Source:SGD;Acc:S000002694]
D	YDR287W	INM2	225	-76.6	4	Inositol monophosphatase, involved in biosynthesis of inositol; enzymatic activity requires magnesium ions and is inhibited by lithium and sodium ions; inm1 inm2 double mutant lacks inositol auxotrophy [Source:SGD;Acc:S000002695]
D	YDR288W	NSE3	146	-145.3	4	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair [Source:SGD;Acc:S000002696]
D	YDR289C	RTT103	778	-251.9	4	Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition [Source:SGD;Acc:S000002697]
D	YDR290W	YDR290W	3	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103 [Source:SGD;Acc:S000002698]
D	YDR291W	HRQ1	184	-246.7	4	Putative RecQ helicase; belongs to the widely conserved RecQ family of proteins which are involved in maintaining genomic integrity; similar to the human RecQ4p implicated in Rothmund-Thomson syndrome(RTS) [Source:SGD;Acc:S000002699]
D	YDR292C	SRP101	1197	-488.7	4	Signal recognition particle (SRP) receptor alpha subunit; contain GTPase domains; involved in SRP-dependent protein targeting; interacts with the beta subunit, Srp102p [Source:SGD;Acc:S000002700]
D	YDR293C	SSD1	2239	-1125.4	4	Translational repressor with a role in polar growth and wall integrity; regulated by Cbk1p phosphorylation to effect bud-specific translational control and localization of specific mRNAs; interacts with TOR pathway components; contains a functional   inal nuclear localization sequence and nucleocytoplasmic shuttling appears to be critical to Ssd1p function [Source:SGD;Acc:S000002701]
D	YDR294C	DPL1	1201	-582.6	4	Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate [Source:SGD;Acc:S000002702]
D	YDR295C	HDA2	432	-435.9	4	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex containing an Hda1p homodimer and an Hda2p-Hda3p heterodimer; involved in telomere maintenance [Source:SGD;Acc:S000002703]
D	YDR296W	MHR1	588	-159.3	4	Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress [Source:SGD;Acc:S000002704]
D	YDR297W	SUR2	387	-85.5	4	Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis [Source:SGD;Acc:S000002705]
D	YDR298C	ATP5	1913	-504.9	4	Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated [Source:SGD;Acc:S000002706]
D	YDR299W	BFR2	1644	-356.7	4	Essential protein that is a component of 90S preribosomes; may be involved in rRNA processing; multicopy suppressor of sensitivity to Brefeldin A; expression is induced during lag phase and also by cold shock [Source:SGD;Acc:S000002707]
D	YDR300C	PRO1	1388	-1520.4	4	Gamma-glutamyl kinase, catalyzes the first step in proline biosynthesis [Source:SGD;Acc:S000002708]
D	YDR301W	CFT1	438	-414.1	4	RNA-binding subunit of the mRNA cleavage and polyadenylation factor; involved in poly(A) site recognition and required for both pre-mRNA cleavage and polyadenylation, 51% sequence similarity with mammalian AAUAA-binding subunit of CPSF [Source:SGD;Acc:S000002709]
D	YDR302W	GPI11	159	-36.8	4	ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog [Source:SGD;Acc:S000002710]
D	YDR303C	RSC3	1185	-409.3	4	Component of the RSC chromatin remodeling complex; essential gene required for maintenance of proper ploidy and regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc30p [Source:SGD;Acc:S000002711]
D	YDR304C	CPR5	1546	-457	4	Peptidyl-prolyl cis-trans isomerase (cyclophilin) of the endoplasmic reticulum, catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; transcriptionally induced in response to unfolded proteins in the ER [Source:SGD;Acc:S000002712]
D	YDR305C	HNT2	338	-197.6	4	Dinucleoside triphosphate hydrolase; has similarity to the tumor suppressor FHIT and belongs to the histidine triad (HIT) superfamily of nucleotide-binding proteins [Source:SGD;Acc:S000002713]
D	YDR306C	YDR306C	22	-80.6	3	F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain [Source:SGD;Acc:S000002714]
D	YDR307W	PMT7	167	-197.4	4	Putative protein of unknown function [Source:SGD;Acc:S000002715]
D	YDR308C	SRB7	182	-94.9	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; target of the global repressor Tup1p [Source:SGD;Acc:S000002716]
D	YDR309C	GIC2	265	-50.1	4	Redundant rho-like GTPase Cdc42p effector; homolog of Gic1p; involved in initiation of budding and cellular polarization; interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain and with PI(4,5)P2 via a polybasic region [Source:SGD;Acc:S000002717]
D	YDR310C	SUM1	1196	-797.5	4	Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint [Source:SGD;Acc:S000002718]
D	YDR311W	TFB1	602	-285.9	4	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, required for nucleotide excision repair, target for transcriptional activators [Source:SGD;Acc:S000002719]
D	YDR312W	SSF2	912	-181.1	4	Protein required for ribosomal large subunit maturation, functionally redundant with Ssf1p; member of the Brix family [Source:SGD;Acc:S000002720]
D	YDR313C	PIB1	197	-109.9	4	RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain [Source:SGD;Acc:S000002721]
D	YDR314C	RAD34	56	-95.6	4	Protein involved in nucleotide excision repair (NER); homologous to RAD4 [Source:SGD;Acc:S000002722]
D	YDR315C	IPK1	21	-47.1	3	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable [Source:SGD;Acc:S000002723]
D	YDR316W	OMS1	294	-270.8	4	Protein integral to the mitochondrial membrane; has a conserved methyltransferase motif; multicopy suppressor of respiratory defects caused by OXA1 mutations [Source:SGD;Acc:S000002724]
D	YDR316W-A	YDR316W-A	4589	-1612.1	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007398]
D	YDR316W-B	YDR316W-B	4935	-2324.9	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007399]
D	YDR317W	HIM1	22	-17.8	2	Protein of unknown function involved in DNA repair [Source:SGD;Acc:S000002725]
D	YDR318W	MCM21	75	-62.7	4	Protein involved in minichromosome maintenance; component of the COMA complex (Ctf19p, Okp1p, Mcm21p, Ame1p) that bridges kinetochore subunits that are in contact with centromeric DNA and the subunits bound to microtubules [Source:SGD;Acc:S000002726]
D	YDR319C	YFT2	5	-2.6	2	Putative protein of unknown function, identified as an ortholog of the highly conserved FIT family of proteins involved in triglyceride droplet biosynthesis; interacts with Sst2p and Hsp82p in high-throughput two-hybrid screens [Source:SGD;Acc:S000002727]
D	YDR320C	SWA2	1023	-408.7	4	Auxilin-like protein involved in vesicular transport; clathrin-binding protein required for uncoating of clathrin-coated vesicles [Source:SGD;Acc:S000002728]
D	YDR320C-A	DAD4	99	-37.3	4	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis [Source:SGD;Acc:S000007604]
D	YDR320W-B	YDR320W-B	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DAD4/YDR320C-A [Source:SGD;Acc:S000028821]
D	YDR321W	ASP1	1722	-358.7	4	Cytosolic L-asparaginase, involved in asparagine catabolism [Source:SGD;Acc:S000002729]
D	YDR322C-A	TIM11	946	-189.3	4	Subunit e of mitochondrial F1F0-ATPase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; essential for the dimeric and oligomeric state of ATP synthase [Source:SGD;Acc:S000007255]
D	YDR322W	MRPL35	714	-267.3	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000002730]
D	YDR323C	PEP7	76	-134.7	4	Multivalent adaptor protein that facilitates vesicle-mediated vacuolar protein sorting by ensuring high-fidelity vesicle docking and fusion, which are essential for targeting of vesicles to the endosome; required for vacuole inheritance [Source:SGD;Acc:S000002731]
D	YDR324C	UTP4	1194	-448.8	4	Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; member of t-Utp subcomplex involved with transcription of 35S rRNA transcript [Source:SGD;Acc:S000002732]
D	YDR325W	YCG1	353	-233.7	4	Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation and chromatin binding of the condensin complex; required for clustering of tRNA genes at the nucleolus [Source:SGD;Acc:S000002733]
D	YDR326C	YSP2	536	-254.2	4	Protein involved in programmed cell death; mutant shows resistance to cell death induced by amiodarone or intracellular acidification [Source:SGD;Acc:S000002734]
D	YDR327W	YDR327W	9	-2.6	2	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SKP1 [Source:SGD;Acc:S000002735]
D	YDR328C	SKP1	1591	-221	4	Evolutionarily conserved kinetochore protein that is part of multiple protein complexes, including the SCF ubiquitin ligase complex, the CBF3 complex that binds centromeric DNA, and the RAVE complex that regulates assembly of the V-ATPase [Source:SGD;Acc:S000002736]
D	YDR329C	PEX3	197	-152.7	4	Peroxisomal membrane protein (PMP) required for proper localization and stability of PMPs; anchors peroxisome retention factor Inp1p at the peroxisomal membrane; interacts with Pex19p [Source:SGD;Acc:S000002737]
D	YDR330W	UBX5	578	-327.5	4	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p [Source:SGD;Acc:S000002738]
D	YDR331W	GPI8	163	-108.4	4	ER membrane glycoprotein subunit of the glycosylphosphatidylinositol transamidase complex that adds glycosylphosphatidylinositol (GPI) anchors to newly synthesized proteins; human PIG-K protein is a functional homolog [Source:SGD;Acc:S000002739]
D	YDR332W	IRC3	65	-116.9	4	Putative RNA helicase of the DEAH/D-box family; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion [Source:SGD;Acc:S000002740]
D	YDR333C	RQC1	601	-309.8	4	Putative protein of unknown function [Source:SGD;Acc:S000002741]
D	YDR334W	SWR1	253	-5518.7	4	Swi2/Snf2-related ATPase that is the structural component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A [Source:SGD;Acc:S000002742]
D	YDR335W	MSN5	936	-602.4	4	Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm [Source:SGD;Acc:S000002743]
D	YDR336W	YDR336W	32	-81	2	Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene [Source:SGD;Acc:S000002744]
D	YDR337W	MRPS28	427	-217.9	4	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000002745]
D	YDR338C	YDR338C	68	-37.5	4	Putative protein of unknown function, member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily [Source:SGD;Acc:S000002746]
D	YDR339C	FCF1	306	-91.4	4	Putative PINc domain nuclease required for early cleavages of 35S pre-rRNA and maturation of 18S rRNA; component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; copurifies with Faf1p [Source:SGD;Acc:S000002747]
D	YDR340W	YDR340W	6	-2.1	2	Putative protein of unknown function [Source:SGD;Acc:S000002748]
D	YDR341C	YDR341C	2977	-1565.3	4	Arginyl-tRNA synthetase, proposed to be cytoplasmic but the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002749]
D	YDR342C	HXT7	2116	-768.3	4	High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt6p, expressed at high basal levels relative to other HXTs, expression repressed by high glucose levels [Source:SGD;Acc:S000002750]
D	YDR343C	HXT6	2077	-814	4	High-affinity glucose transporter of the major facilitator superfamily, nearly identical to Hxt7p, expressed at high basal levels relative to other HXTs, repression of expression by high glucose requires SNF3 [Source:SGD;Acc:S000002751]
D	YDR344C	YDR344C	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002752]
D	YDR345C	HXT3	2085	-334.9	4	Low affinity glucose transporter of the major facilitator superfamily, expression is induced in low or high glucose conditions [Source:SGD;Acc:S000002753]
D	YDR346C	SVF1	1655	-437.5	4	Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000002754]
D	YDR347W	MRP1	1013	-235.9	4	Mitochondrial ribosomal protein of the small subunit; MRP1 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator, and with PET123, encoding a small subunit mitochondrial ribosomal protein [Source:SGD;Acc:S000002755]
D	YDR348C	PAL1	1324	-654.2	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud neck; potential Cdc28p substrate [Source:SGD;Acc:S000002756]
D	YDR349C	YPS7	160	-86	4	Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; located in the cytoplasm and endoplasmic reticulum [Source:SGD;Acc:S000002757]
D	YDR350C	ATP22	35	-102.5	4	Specific translational activator for the mitochondrial ATP6 mRNA, encoding a subunit of F1F0 ATP synthase; localized to the mitochondrial inner membrane [Source:SGD;Acc:S000002758]
D	YDR351W	SBE2	370	-109.2	4	Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth [Source:SGD;Acc:S000002759]
D	YDR352W	YPQ2	121	-116.9	4	Putative protein of unknown function [Source:SGD;Acc:S000002760]
D	YDR353W	TRR1	2827	-543.4	4	Cytoplasmic thioredoxin reductase, key regulatory enzyme that determines the redox state of the thioredoxin system, which acts as a disulfide reductase system and protects cells against both oxidative and reductive stress [Source:SGD;Acc:S000002761]
D	YDR354C-A	YDR354C-A	8	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps TRP4; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028613]
D	YDR354W	TRP4	828	-274.3	4	Anthranilate phosphoribosyl transferase of the tryptophan biosynthetic pathway, catalyzes the phosphoribosylation of anthranilate, subject to the general control system of amino acid biosynthesis [Source:SGD;Acc:S000002762]
D	YDR355C	YDR355C	2	-1.5	1	Dubious: Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified essential ORF SPC110/YDR356W [Source:SGD;Acc:S000002763]
D	YDR356W	SPC110	981	-514.6	4	Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner [Source:SGD;Acc:S000002764]
D	YDR357C	CNL1	104	-58.1	4	Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000002765]
D	YDR358W	GGA1	1138	-517.6	4	Golgi-localized protein with homology to gamma-adaptin, interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner in order to facilitate traffic through the late Golgi [Source:SGD;Acc:S000002766]
D	YDR359C	EAF1	389	-495.6	4	Component of the NuA4 histone acetyltransferase complex; acts as a platform for assembly of NuA4 subunits into the native complex; required for initiation of pre-meiotic DNA replication, likely due to its requirement for expression of IME1 [Source:SGD;Acc:S000002767]
D	YDR360W	OPI7	5	-2.8	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene VID21/YDR359C. [Source:SGD;Acc:S000002768]
D	YDR361C	BCP1	1209	-263	4	Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport [Source:SGD;Acc:S000002769]
D	YDR362C	TFC6	184	-149.6	4	One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; cooperates with Tfc3p in DNA binding; human homolog is TFIIIC-110 [Source:SGD;Acc:S000002770]
D	YDR363W	ESC2	157	-96.8	4	Sumo-like domain protein; prevents accumulation of toxic intermediates during replication-associated recombinational repair; roles in silencing, lifespan, chromatid cohesion and the intra-S-phase DNA damage checkpoint; RENi family member [Source:SGD;Acc:S000002771]
D	YDR363W-A	SEM1	876	-144.2	4	Component of the lid subcomplex of the regulatory subunit of the 26S proteasome; involved in mRNA export mediated by the TREX-2 complex (Sac3p-Thp1p); ortholog of human DSS1 [Source:SGD;Acc:S000007235]
D	YDR364C	CDC40	156	-161.8	4	Pre-mRNA splicing factor, important for catalytic step II of pre-mRNA splicing and plays a role in cell cycle progression; required for DNA synthesis during mitosis and meiosis; has WD repeats [Source:SGD;Acc:S000002772]
D	YDR365C	ESF1	1619	-359.5	4	Nucleolar protein involved in pre-rRNA processing; depletion causes severely decreased 18S rRNA levels [Source:SGD;Acc:S000002773]
D	YDR365W-A	YDR365W-A	4727	-1742.3	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007400]
D	YDR365W-B	YDR365W-B	5019	-2495.9	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007401]
D	YDR366C	YDR366C	2	-2	2	Putative protein of unknown function [Source:SGD;Acc:S000002774]
D	YDR367W	KEI1	100	-33.2	4	Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene [Source:SGD;Acc:S000002775]
D	YDR368W	YPR1	2137	-472.1	4	NADPH-dependent aldo-keto reductase, reduces multiple substrates including 2-methylbutyraldehyde and D,L-glyceraldehyde, expression is induced by osmotic and oxidative stress; functionally redundant with other aldo-keto reductases [Source:SGD;Acc:S000002776]
D	YDR369C	XRS2	260	-164.6	4	Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling [Source:SGD;Acc:S000002777]
D	YDR370C	DXO1	95	-56.6	4	Putative protein of unknown function [Source:SGD;Acc:S000002778]
D	YDR371C-A	YDR371C-A	4	-2.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completeley overlaps the uncharacterized gene CTS2/YDR371W; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028822]
D	YDR371W	CTS2	121	-167.5	4	Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect [Source:SGD;Acc:S000002779]
D	YDR372C	VPS74	1270	-324.6	4	Protein required for Golgi localization of glycosyltransferases; binds the cytosolic domains of Golgi glycosyltransferases; binding to PtdIns4P required for Golgi targeting and function; tetramer formation required for function [Source:SGD;Acc:S000002780]
D	YDR373W	FRQ1	199	-125.5	4	N-myristoylated calcium-binding protein that may have a role in intracellular signaling through its regulation of the phosphatidylinositol 4-kinase Pik1p; member of the recoverin/frequenin branch of the EF-hand superfamily [Source:SGD;Acc:S000002781]
D	YDR374C	PHO92	13	-9.5	2	Putative protein of unknown function [Source:SGD;Acc:S000002782]
D	YDR374W-A	WIP1	58	-38.9	4	Putative protein of unknown function [Source:SGD;Acc:S000113553]
D	YDR375C	BCS1	276	-205.6	4	Mitochondrial protein of the AAA ATPase family; has ATP-dependent chaperone activity; required for assembly of Rip1p and Qcr10p into cytochrome bc(1) complex; mutations in human homolog BCS1L are linked to neonatal mitochondrial diseases [Source:SGD;Acc:S000002783]
D	YDR376W	ARH1	490	-236.5	4	Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability [Source:SGD;Acc:S000002784]
D	YDR377W	ATP17	438	-133.4	4	Subunit f of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis [Source:SGD;Acc:S000002785]
D	YDR378C	LSM6	1159	-179	4	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA [Source:SGD;Acc:S000002786]
D	YDR379C-A	SDH6	154	-59.6	4	Protein involved in the assembly of the mitochondrial succinate dehydrogenase complex; mutations in human ortholog SDHAF1 are associated with infantile leukoencephalopathy [Source:SGD;Acc:S000007605]
D	YDR379W	RGA2	546	-381.6	4	GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth; regulated by Pho85p and Cdc28p [Source:SGD;Acc:S000002787]
D	YDR380W	ARO10	943	-750.9	4	Phenylpyruvate decarboxylase, catalyzes decarboxylation of phenylpyruvate to phenylacetaldehyde, which is the first specific step in the Ehrlich pathway [Source:SGD;Acc:S000002788]
D	YDR381C-A	YDR381C-A	208	-75.8	4	Protein of unknown function, localized to the mitochondrial outer membrane [Source:SGD;Acc:S000007650]
D	YDR381W	YRA1	2646	-346.5	4	RNA binding protein required for export of poly(A)+ mRNA from the nucleus; proposed to couple mRNA export with 3' end processing via its interactions with Mex67p and Pcf11p; functionally redundant with Yra2p, another REF family member [Source:SGD;Acc:S000002789]
D	YDR382W	RPP2B	4063	-1231.7	4	Ribosomal protein P2 beta, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm [Source:SGD;Acc:S000002790]
D	YDR383C	NKP1	149	-92.6	4	Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p) [Source:SGD;Acc:S000002791]
D	YDR384C	ATO3	347	-70.9	4	Plasma membrane protein, regulation pattern suggests a possible role in export of ammonia from the cell; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family of putative transporters [Source:SGD;Acc:S000002792]
D	YDR385W	EFT2	6190	-3703.6	4	Elongation factor 2 (EF-2), also encoded by EFT1; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin [Source:SGD;Acc:S000002793]
D	YDR386W	MUS81	77	-104.5	4	Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein [Source:SGD;Acc:S000002794]
D	YDR387C	YDR387C	26	-20.2	2	Putative transporter, member of the sugar porter family; YDR387C is not an essential gene [Source:SGD;Acc:S000002795]
D	YDR388W	RVS167	1989	-489.1	4	Actin-associated protein with roles in endocytosis and exocytosis; interacts with Rvs161p to regulate actin cytoskeleton, endocytosis, and viability following starvation or osmotic stress; recruited to bud tips by Gyl1p and Gyp5p during polarized gr  homolog of mammalian amphiphysin [Source:SGD;Acc:S000002796]
D	YDR389W	SAC7	588	-240	4	GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate [Source:SGD;Acc:S000002797]
D	YDR390C	UBA2	871	-385.5	4	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Aos1p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability [Source:SGD;Acc:S000002798]
D	YDR391C	YDR391C	463	-107.3	4	Putative protein of unknown function, possibly involved in zinc homeostasis; Bdf1p-dependent transcription induced by salt stress; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000002799]
D	YDR392W	SPT3	419	-424.2	4	Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters [Source:SGD;Acc:S000002800]
D	YDR393W	SHE9	111	-187.4	4	Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex [Source:SGD;Acc:S000002801]
D	YDR394W	RPT3	2324	-383.2	4	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; substrate of N-acetyltransferase B [Source:SGD;Acc:S000002802]
D	YDR395W	SXM1	1591	-727.6	4	Nuclear transport factor (karyopherin) involved in protein transport between the cytoplasm and nucleoplasm; similar to Nmd5p, Cse1p, Lph2p, and the human cellular apoptosis susceptibility protein, CAS1 [Source:SGD;Acc:S000002803]
D	YDR396W	YDR396W	2	-1.8	1	Dubious open reading frame unlikely to encode a functional protein; extensively overlaps essential NCB2 gene encoding the beta subunit of the NC2 dimeric histone-fold complex [Source:SGD;Acc:S000002804]
D	YDR397C	NCB2	677	-85.9	4	Subunit of a heterodimeric NC2 transcription regulator complex with Bur6p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2beta [Source:SGD;Acc:S000002805]
D	YDR398W	UTP5	815	-320.3	4	Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit [Source:SGD;Acc:S000002806]
D	YDR399W	HPT1	1632	-439.6	4	Dimeric hypoxanthine-guanine phosphoribosyltransferase, catalyzes the formation of both inosine monophosphate and guanosine monophosphate; mutations in the human homolog HPRT1 can cause Lesch-Nyhan syndrome and Kelley-Seegmiller syndrome [Source:SGD;Acc:S000002807]
D	YDR400W	URH1	236	-69.8	4	Uridine nucleosidase (uridine-cytidine N-ribohydrolase), cleaves N-glycosidic bonds in nucleosides; involved in the pyrimidine salvage and nicotinamide riboside salvage pathways [Source:SGD;Acc:S000002808]
D	YDR401W	YDR401W	6	-1.9	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002809]
D	YDR402C	DIT2	15	-3.4	2	N-formyltyrosine oxidase, sporulation-specific microsomal enzyme involved in the production of N,N-bisformyl dityrosine required for spore wall maturation, homologous to cytochrome P-450s [Source:SGD;Acc:S000002810]
D	YDR403W	DIT1	18	-8.1	2	Sporulation-specific enzyme required for spore wall maturation, involved in the production of a soluble LL-dityrosine-containing precursor of the spore wall; transcripts accumulate at the time of prospore enclosure [Source:SGD;Acc:S000002811]
D	YDR404C	RPB7	619	-201.7	4	RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved  anslation initiation [Source:SGD;Acc:S000002812]
D	YDR405W	MRP20	497	-99.7	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000002813]
D	YDR406W	PDR15	1673	-860.1	4	Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element [Source:SGD;Acc:S000002814]
D	YDR406W-A	YDR406W-A	1	-1.4	1	Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028543]
D	YDR407C	TRS120	671	-362.8	4	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic [Source:SGD;Acc:S000002815]
D	YDR408C	ADE8	753	-404.7	4	Phosphoribosyl-glycinamide transformylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway [Source:SGD;Acc:S000002816]
D	YDR409W	SIZ1	269	-238	4	SUMO/Smt3 ligase that promotes the attachment of sumo (Smt3p; small ubiquitin-related modifier) to proteins; binds Ubc9p and may bind septins; specifically required for sumoylation of septins in vivo; localized to the septin ring [Source:SGD;Acc:S000002817]
D	YDR410C	STE14	40	-34.4	4	Farnesyl cysteine-carboxyl methyltransferase, mediates the carboxyl methylation step during C-terminal CAAX motif processing of a-factor and RAS proteins in the endoplasmic reticulum, localizes to the ER membrane [Source:SGD;Acc:S000002818]
D	YDR411C	DFM1	703	-166.6	4	Endoplasmic reticulum (ER) localized protein involved in ER-associated protein degradation (ERAD), ER stress and homeostasis; interacts with components of ERAD-L and ERAD-C and Cdc48p; derlin-like family member similar to Der1p [Source:SGD;Acc:S000002819]
D	YDR412W	RRP17	263	-120.9	4	Component of the pre-60S pre-ribosomal particle; required for cell viability under standard (aerobic) conditions but not under anaerobic conditions; exonuclease required for 5′ end processing of pre-60S ribosomal RNA [Source:SGD;Acc:S000002820]
D	YDR413C	YDR413C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the essential uncharacterized ORF YDR412W that is implicated in rRNA processing [Source:SGD;Acc:S000002821]
D	YDR414C	ERD1	25	-28.7	4	Predicted membrane protein required for the retention of lumenal endoplasmic reticulum proteins; mutants secrete the endogenous ER protein, BiP (Kar2p) [Source:SGD;Acc:S000002822]
D	YDR415C	YDR415C	104	-119.5	4	Putative protein of unknown function [Source:SGD;Acc:S000002823]
D	YDR416W	SYF1	194	-466.7	4	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; null mutant has splicing defect and arrests in G2/M; homologs in human and C. elegans [Source:SGD;Acc:S000002824]
D	YDR417C	YDR417C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W [Source:SGD;Acc:S000002825]
D	YDR418W	RPL12B	4915	-458.3	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Ap; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins [Source:SGD;Acc:S000002826]
D	YDR419W	RAD30	87	-80.9	4	DNA polymerase eta, involved in translesion synthesis during post-replication repair; catalyzes the synthesis of DNA opposite cyclobutane pyrimidine dimers and other lesions; mutations in human pol eta are responsible for XPV [Source:SGD;Acc:S000002827]
D	YDR420W	HKR1	27	-36.3	2	Mucin family member that functions as an osmosensor in the Sho1p-mediated HOG pathway with Msb2p; proposed to be a negative regulator of filamentous growth; mutant displays defects in beta-1,3 glucan synthesis and bud site selection [Source:SGD;Acc:S000002828]
D	YDR421W	ARO80	137	-212.3	4	Zinc finger transcriptional activator of the Zn2Cys6 family; activates transcription of aromatic amino acid catabolic genes in the presence of aromatic amino acids [Source:SGD;Acc:S000002829]
D	YDR422C	SIP1	629	-798.6	4	Alternate beta-subunit of the Snf1p kinase complex, may confer substrate specificity; vacuolar protein containing KIS (Kinase-Interacting Sequence) and ASC (Association with Snf1 kinase Complex) domains involved in protein interactions [Source:SGD;Acc:S000002830]
D	YDR423C	CAD1	120	-95.6	4	AP-1-like basic leucine zipper (bZIP) transcriptional activator involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA [Source:SGD;Acc:S000002831]
D	YDR424C	DYN2	562	-224.3	4	Cytoplasmic light chain dynein, microtubule motor protein; proposed to be involved in the assembly of the nuclear pore complex [Source:SGD;Acc:S000002832]
D	YDR425W	SNX41	246	-219.2	4	Sorting nexin, involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p [Source:SGD;Acc:S000002833]
D	YDR426C	YDR426C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SNX41 [Source:SGD;Acc:S000002834]
D	YDR427W	RPN9	1436	-551.9	4	Non-ATPase regulatory subunit of the 26S proteasome, has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects [Source:SGD;Acc:S000002835]
D	YDR428C	BNA7	682	-207.1	4	Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine [Source:SGD;Acc:S000002836]
D	YDR429C	TIF35	2423	-388.5	4	eIF3g subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates resumption of ribosomal scanning during translation reinitiation [Source:SGD;Acc:S000002837]
D	YDR430C	CYM1	1049	-827.4	4	Lysine-specific metalloprotease of the mitochondrial intermembrane space, member of the pitrilysin family; degrades proteins and presequence peptides cleaved from imported proteins; required for normal mitochondrial morphology [Source:SGD;Acc:S000002838]
D	YDR431W	YDR431W	1	-1	1	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002839]
D	YDR432W	NPL3	3145	-430.3	4	RNA-binding protein that promotes elongation, regulates termination, and carries poly(A) mRNA from nucleus to cytoplasm; required for pre-mRNA splicing; dissociation from mRNAs promoted by Mtr10p; phosphorylated by Sky1p in the cytoplasm [Source:SGD;Acc:S000002840]
D	YDR433W	YDR433W	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002841]
D	YDR434W	GPI17	919	-247.1	4	Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Sp homolog [Source:SGD;Acc:S000002842]
D	YDR435C	PPM1	419	-218	4	Carboxyl methyltransferase, methylates the C terminus of the protein phosphatase 2A catalytic subunit (Pph21p or Pph22p), which is important for complex formation with regulatory subunits [Source:SGD;Acc:S000002843]
D	YDR436W	PPZ2	1234	-873.4	4	Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance [Source:SGD;Acc:S000002844]
D	YDR437W	GPI19	6	-7.3	2	Subunit of GPI-GlcNAc transferase involved in synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), which is the first intermediate in glycosylphosphatidylinositol (GPI) anchor synthesis, shares similarity with mammalian PIG-P [Source:SGD;Acc:S000002845]
D	YDR438W	THI74	3	-3	2	Mitochondrial transporter repressible by thiamine [Source:SGD;Acc:S000002846]
D	YDR439W	LRS4	274	-134.4	4	Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation [Source:SGD;Acc:S000002847]
D	YDR440W	DOT1	228	-196.7	4	Nucleosomal histone H3-Lys79 methylase; methylation is required for telomeric silencing, meiotic checkpoint control, and DNA damage response [Source:SGD;Acc:S000002848]
D	YDR441C	APT2	283	-62.4	4	Apparent pseudogene, not transcribed or translated under normal conditions; encodes a protein with similarity to adenine phosphoribosyltransferase, but artificially expressed protein exhibits no enzymatic activity [Source:SGD;Acc:S000002849]
D	YDR442W	YDR442W	1	0	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002850]
D	YDR443C	SSN2	433	-230.1	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for stable association of Srb10p-Srb11p kinase; essential for transcriptional regulation [Source:SGD;Acc:S000002851]
D	YDR444W	YDR444W	169	-197	4	Putative protein of unknown function [Source:SGD;Acc:S000002852]
D	YDR445C	YDR445C	5	-4.7	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002853]
D	YDR446W	ECM11	16	-133.9	4	Non-essential protein apparently involved in meiosis, GFP fusion protein is present in discrete clusters in the nucleus throughout mitosis; may be involved in maintaining chromatin structure [Source:SGD;Acc:S000002854]
D	YDR447C	RPS17B	4627	-651.9	4	Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Ap and has similarity to rat S17 ribosomal protein [Source:SGD;Acc:S000002855]
D	YDR448W	ADA2	458	-448.7	4	Transcription coactivator, component of the ADA and SAGA transcriptional adaptor/HAT (histone acetyltransferase) complexes [Source:SGD;Acc:S000002856]
D	YDR449C	UTP6	730	-240.3	4	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [Source:SGD;Acc:S000002857]
D	YDR450W	RPS18A	5038	-513.7	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Bp and has similarity to E. coli S13 and rat S18 ribosomal proteins [Source:SGD;Acc:S000002858]
D	YDR451C	YHP1	39	-24.1	2	One of two homeobox transcriptional repressors (see also Yox1p), that bind to Mcm1p and to early cell cycle box (ECB) elements of cell cycle regulated genes, thereby restricting ECB-mediated transcription to the M/G1 interval [Source:SGD;Acc:S000002859]
D	YDR452W	PPN1	824	-323.1	4	Vacuolar endopolyphosphatase with a role in phosphate metabolism; functions as a homodimer [Source:SGD;Acc:S000002860]
D	YDR453C	TSA2	2017	-244.2	4	Stress inducible cytoplasmic thioredoxin peroxidase; cooperates with Tsa1p in the removal of reactive oxygen, nitrogen and sulfur species using thioredoxin as hydrogen donor; deletion enhances the mutator phenotype of tsa1 mutants [Source:SGD;Acc:S000002861]
D	YDR454C	GUK1	2298	-377	4	Guanylate kinase, converts GMP to GDP; required for growth and mannose outer chain elongation of cell wall N-linked glycoproteins [Source:SGD;Acc:S000002862]
D	YDR455C	YDR455C	8	-2.7	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W [Source:SGD;Acc:S000002863]
D	YDR456W	NHX1	214	-92.2	4	Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion [Source:SGD;Acc:S000002864]
D	YDR457W	TOM1	1561	-1511.4	4	E3 ubiquitin ligase of the hect-domain class; has a role in mRNA export from the nucleus and may regulate transcriptional coactivators; involved in degradation of excess histones [Source:SGD;Acc:S000002865]
D	YDR458C	HEH2	695	-420.3	4	Inner nuclear membrane (INM) protein; contains helix-extension-helix (HEH) motif, nuclear localization signal sequence; targeting to the INM requires the Srp1p-Kap95p karyopherins and the Ran cycle [Source:SGD;Acc:S000002866]
D	YDR459C	PFA5	13	-4.1	2	Palmitoyltransferase with autoacylation activity; likely functions in pathway(s) outside Ras; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain [Source:SGD;Acc:S000002867]
D	YDR460W	TFB3	499	-156.1	4	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair; ring finger protein similar to mammalian CAK and TFIIH subunit [Source:SGD;Acc:S000002868]
D	YDR461C-A	YDR461C-A	93	-32.8	4	Putative protein of unknown function [Source:SGD;Acc:S000087209]
D	YDR461W	MFA1	10	-9.4	2	Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA2 [Source:SGD;Acc:S000002869]
D	YDR462W	MRPL28	337	-80.2	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000002870]
D	YDR463W	STP1	101	-40.5	4	Transcription factor, undergoes proteolytic processing by SPS (Ssy1p-Ptr3p-Ssy5p)-sensor component Ssy5p in response to extracellular amino acids; activates transcription of amino acid permease genes and may have a role in tRNA processing [Source:SGD;Acc:S000002871]
D	YDR464C-A	YDR464C-A	32	-4	2	Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028614]
D	YDR464W	SPP41	699	-348.6	4	Protein involved in negative regulation of expression of spliceosome components PRP4 and PRP3 [Source:SGD;Acc:S000002872]
D	YDR465C	RMT2	829	-181.3	4	Arginine N5 methyltransferase; methylates ribosomal protein Rpl12 (L12) on Arg67 [Source:SGD;Acc:S000002873]
D	YDR466W	PKH3	490	-1754.9	4	Protein kinase with similarity to mammalian phosphoinositide-dependent kinase 1 (PDK1) and yeast Pkh1p and Pkh2p, two redundant upstream activators of Pkc1p; identified as a multicopy suppressor of a pkh1 pkh2 double mutant [Source:SGD;Acc:S000002874]
D	YDR467C	YDR467C	1	-1.2	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002875]
D	YDR468C	TLG1	273	-154.6	4	Essential t-SNARE that forms a complex with Tlg2p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds the docking complex VFT (Vps fifty-three) through interaction with Vps51p [Source:SGD;Acc:S000002876]
D	YDR469W	SDC1	504	-105.1	4	Subunit of the COMPASS (Set1C) complex, which methylates lysine 4 of histone H3 and is required in chromatin silencing at telomeres; contains a Dpy-30 domain that mediates interaction with Bre2p; similar to C. elegans and human DPY-30 [Source:SGD;Acc:S000002877]
D	YDR470C	UGO1	364	-232.6	4	Outer membrane component of the mitochondrial fusion machinery; binds directly to Fzo1p and Mgm1p and thus links these two GTPases during mitochondrial fusion; involved in fusion of both the outer and inner membranes; facilitates dimerization of Fzo  ing fusion; import into the outer membrane is mediated by Tom70p and Mim1p; has similarity to carrier proteins but is not likely to function as a transmembrane transporter [Source:SGD;Acc:S000002878]
D	YDR471W	RPL27B	4174	-542.5	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Ap and has similarity to rat L27 ribosomal protein [Source:SGD;Acc:S000002879]
D	YDR472W	TRS31	587	-198.2	4	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic [Source:SGD;Acc:S000002880]
D	YDR473C	PRP3	223	-179.3	4	Splicing factor, component of the U4/U6-U5 snRNP complex [Source:SGD;Acc:S000002881]
D	YDR475C	JIP4	542	-274	4	Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence [Source:SGD;Acc:S000002883]
D	YDR476C	YDR476C	524	-98.4	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR476C is not an essential gene [Source:SGD;Acc:S000002884]
D	YDR477W	SNF1	1739	-1160.9	4	AMP-activated serine/threonine protein kinase found in a complex containing Snf4p and members of the Sip1p/Sip2p/Gal83p family; required for transcription of glucose-repressed genes, thermotolerance, sporulation, and peroxisome biogenesis [Source:SGD;Acc:S000002885]
D	YDR478W	SNM1	90	-38.3	4	Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP [Source:SGD;Acc:S000002886]
D	YDR479C	PEX29	146	-314	4	Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p [Source:SGD;Acc:S000002887]
D	YDR480W	DIG2	457	-355.8	4	MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p [Source:SGD;Acc:S000002888]
D	YDR481C	PHO8	1203	-323.4	4	Repressible vacuolar alkaline phosphatase; regulated by levels of Pi and by Pho4p, Pho9p, Pho80p, Pho81p and Pho85p; dephosphorylates phosphotyrosyl peptides; contributes to NAD+ metabolism by producing nicotinamide riboside from NMN [Source:SGD;Acc:S000002889]
D	YDR482C	CWC21	105	-67.6	4	Protein involved in RNA splicing by the spliceosome; component of a complex containing Cef1p; interacts genetically with ISY1 and BUD13; may bind RNA; has similarity to S. pombe Cwf21p [Source:SGD;Acc:S000002890]
D	YDR483W	KRE2	1910	-441.8	4	Alpha1,2-mannosyltransferase of the Golgi involved in protein mannosylation [Source:SGD;Acc:S000002891]
D	YDR484W	VPS52	255	-280.2	4	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; involved in localization of actin and chitin [Source:SGD;Acc:S000002892]
D	YDR485C	VPS72	207	-2478.2	4	Htz1p-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting [Source:SGD;Acc:S000002893]
D	YDR486C	VPS60	494	-76.4	4	Cytoplasmic and vacuolar membrane protein involved in late endosome to vacuole transport; required for normal filament maturation during pseudohyphal growth; may function in targeting cargo proteins for degradation; interacts with Vta1p [Source:SGD;Acc:S000002894]
D	YDR487C	RIB3	1639	-326.2	4	3,4-dihydroxy-2-butanone-4-phosphate synthase (DHBP synthase), required for riboflavin biosynthesis from ribulose-5-phosphate, also has an unrelated function in mitochondrial respiration [Source:SGD;Acc:S000002895]
D	YDR488C	PAC11	119	-69.4	4	Dynein intermediate chain, acts in the cytoplasmic dynein pathway, forms cortical cytoplasmic microtubule capture site with Num1p; null mutant is defective in nuclear migration, essential in the absence of CIN8 [Source:SGD;Acc:S000002896]
D	YDR489W	SLD5	199	-209.1	4	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery [Source:SGD;Acc:S000002897]
D	YDR490C	PKH1	662	-1439.1	4	Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh2p [Source:SGD;Acc:S000002898]
D	YDR491C	YDR491C	3	-1.4	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002899]
D	YDR492W	IZH1	43	-28.4	4	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc [Source:SGD;Acc:S000002900]
D	YDR493W	MZM1	352	-74.6	4	Protein required for assembly of the cytochrome bc(1) complex; facilitates insertion of Rip1p into the complex at a late stage of assembly; localized to the mitochondrial matrix; null mutant exhibits a respiratory growth defect and reduced mitochond  inc levels, which is characteristic of mutations affecting bc(1) complex assembly; conserved in metazoans [Source:SGD;Acc:S000002901]
D	YDR494W	RSM28	556	-373.4	4	Mitochondrial ribosomal protein of the small subunit; genetic interactions suggest a possible role in promoting translation initiation [Source:SGD;Acc:S000002902]
D	YDR495C	VPS3	213	-355.3	4	Component of CORVET tethering complex; cytoplasmic protein required for the sorting and processing of soluble vacuolar proteins, acidification of the vacuolar lumen, and assembly of the vacuolar H+-ATPase [Source:SGD;Acc:S000002903]
D	YDR496C	PUF6	1622	-258.4	4	Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis [Source:SGD;Acc:S000002904]
D	YDR497C	ITR1	903	-127.2	4	Myo-inositol transporter with strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p [Source:SGD;Acc:S000002905]
D	YDR498C	SEC20	198	-128.8	4	Membrane glycoprotein v-SNARE involved in retrograde transport from the Golgi to the ER; required for N- and O-glycosylation in the Golgi but not in the ER; interacts with the Dsl1p complex through Tip20p [Source:SGD;Acc:S000002906]
D	YDR499W	LCD1	206	-237.2	4	Essential protein required for the DNA integrity checkpoint pathways; interacts physically with Mec1p; putative homolog of S. pombe Rad26 and human ATRIP [Source:SGD;Acc:S000002907]
D	YDR500C	RPL37B	1457	-144.8	4	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Ap and to rat L37 ribosomal protein [Source:SGD;Acc:S000002908]
D	YDR501W	PLM2	72	-159.3	4	Forkhead Associated domain containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; induced in response to DNA damaging agents and deletion of telomerase; similar to TOS4 [Source:SGD;Acc:S000002909]
D	YDR502C	SAM2	4417	-1098.8	4	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) [Source:SGD;Acc:S000002910]
D	YDR503C	LPP1	32	-60.8	4	Lipid phosphate phosphatase, catalyzes Mg(2+)-independent dephosphorylation of phosphatidic acid (PA), lysophosphatidic acid, and diacylglycerol pyrophosphate; involved in control of the cellular levels of phosphatidylinositol and PA [Source:SGD;Acc:S000002911]
D	YDR504C	SPG3	0	nf	1	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources [Source:SGD;Acc:S000002912]
D	YDR505C	PSP1	842	-428.9	4	Asn and gln rich protein of unknown function; high-copy suppressor of POL1 (DNA polymerase alpha) and partial suppressor of CDC2 (polymerase delta) and CDC6 (pre-RC loading factor) mutations; overexpression results in growth inhibition [Source:SGD;Acc:S000002913]
D	YDR506C	GMC1	63	-97.9	4	Possible membrane-localized protein [Source:SGD;Acc:S000002914]
D	YDR507C	GIN4	1388	-1380.1	4	Protein kinase involved in bud growth and assembly of the septin ring, proposed to have kinase-dependent and kinase-independent activities; undergoes autophosphorylation; similar to Kcc4p and Hsl1p [Source:SGD;Acc:S000002915]
D	YDR508C	GNP1	1304	-226.3	4	High-affinity glutamine permease, also transports Leu, Ser, Thr, Cys, Met and Asn; expression is fully dependent on Grr1p and modulated by the Ssy1p-Ptr3p-Ssy5p (SPS) sensor of extracellular amino acids [Source:SGD;Acc:S000002916]
D	YDR509W	YDR509W	3	-1.6	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002917]
D	YDR510C-A	YDR510C-A	0	nf	1	Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028615]
D	YDR510W	SMT3	1913	-205	4	Ubiquitin-like protein of the SUMO family, conjugated to lysine residues of target proteins; regulates chromatid cohesion, chromosome segregation, APC-mediated proteolysis, DNA replication and septin ring dynamics; phosphorylated at Ser2 [Source:SGD;Acc:S000002918]
D	YDR511W	SDH7	378	-102	4	Protein of the mitochondrial intermembrane space, required for acetate utilization and gluconeogenesis; has orthologs in higher eukaryotes [Source:SGD;Acc:S000002919]
D	YDR512C	EMI1	142	-64.1	4	Non-essential protein required for transcriptional induction of the early meiotic-specific transcription factor IME1, also required for sporulation; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000002920]
D	YDR513W	GRX2	2008	-273.7	4	Cytoplasmic glutaredoxin, thioltransferase, glutathione-dependent disulfide oxidoreductase involved in maintaining redox state of target proteins, also exhibits glutathione peroxidase activity, expression induced in response to stress [Source:SGD;Acc:S000002921]
D	YDR514C	YDR514C	173	-106	4	Protein of unknown function that localizes to mitochondria; overexpression of YDR514C affects endocytic protein trafficking [Source:SGD;Acc:S000002922]
D	YDR515W	SLF1	672	-274.5	4	RNA binding protein that associates with polysomes; proposed to be involved in regulating mRNA translation; involved in the copper-dependent mineralization of copper sulfide complexes on cell surface in cells cultured in copper salts [Source:SGD;Acc:S000002923]
D	YDR516C	EMI2	1894	-793.3	4	Non-essential protein of unknown function required for transcriptional induction of the early meiotic-specific transcription factor IME1; required for sporulation; expression is regulated by glucose-repression transcription factors Mig1/2p [Source:SGD;Acc:S000002924]
D	YDR517W	GRH1	894	-233.8	4	Acetylated, cis-golgi localized protein involved in ER to Golgi transport; homolog of human GRASP65; forms a complex with the coiled-coil protein Bug1p; mutants are compromised for the fusion of ER-derived vesicles with Golgi membranes [Source:SGD;Acc:S000002925]
D	YDR518W	EUG1	897	-195.3	4	Protein disulfide isomerase of the endoplasmic reticulum lumen, function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER [Source:SGD;Acc:S000002926]
D	YDR519W	FPR2	1019	-146.9	4	Membrane-bound peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; expression pattern suggests possible involvement in ER protein trafficking [Source:SGD;Acc:S000002927]
D	YDR520C	URC2	120	-77.2	4	Putative Zn(II)2Cys6 motif containing transcription factor; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; similar to S. kluyveri Urc2p involved in uracil catabolism [Source:SGD;Acc:S000002928]
D	YDR521W	YDR521W	0	nf	1	Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol [Source:SGD;Acc:S000002929]
D	YDR522C	SPS2	40	-81.9	4	Protein expressed during sporulation, redundant with Sps22p for organization of the beta-glucan layer of the spore wall; S. pombe ortholog is a spore wall component [Source:SGD;Acc:S000002930]
D	YDR523C	SPS1	13	-844.7	4	Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis [Source:SGD;Acc:S000002931]
D	YDR524C	AGE1	138	-74.6	4	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in the secretory and endocytic pathways; contains C2C2H2 cysteine/histidine motif [Source:SGD;Acc:S000002932]
D	YDR524C-A	YDR524C-A	1	-1.1	1	Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028616]
D	YDR524C-B	YDR524C-B	11	-8	3	Putative protein of unknown function [Source:SGD;Acc:S000028739]
D	YDR524W-C	YDR524W-C	0	nf	1	Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin [Source:SGD;Acc:S000028740]
D	YDR525W	API2	3	-2.9	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 26% of ORF overlaps the dubious ORF YDR524C-A; insertion mutation in a cdc34-2 mutant background causes altered bud morphology [Source:SGD;Acc:S000002933]
D	YDR525W-A	SNA2	172	-44.7	4	Protein of unknown function, has similarity to Pmp3p, which is involved in cation transport; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000007236]
D	YDR526C	YDR526C	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002934]
D	YDR527W	RBA50	450	-298.9	4	Protein involved in transcription; interacts with RNA polymerase II subunits Rpb2p, Rpb3, and Rpb11p; has similarity to human RPAP1 [Source:SGD;Acc:S000002935]
D	YDR528W	HLR1	94	-56.2	4	Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A [Source:SGD;Acc:S000002936]
D	YDR529C	QCR7	1227	-277.8	4	Subunit 7 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the mitochondrial matrix; N-terminus appears to play a role in complex assembly [Source:SGD;Acc:S000002937]
D	YDR530C	APA2	397	-172.4	4	Diadenosine 5',5''-P1,P4-tetraphosphate phosphorylase II (AP4A phosphorylase), involved in catabolism of bis(5'-nucleosidyl) tetraphosphates; has similarity to Apa1p [Source:SGD;Acc:S000002938]
D	YDR531W	CAB1	500	-195.8	4	Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element [Source:SGD;Acc:S000002939]
D	YDR532C	KRE28	149	-77.8	4	Subunit of a kinetochore-microtubule binding complex with Spc105p that bridges centromeric heterochromatin and kinetochore MAPs and motors, and is also required for sister chromatid bi-orientation and kinetochore binding of SAC components [Source:SGD;Acc:S000002940]
D	YDR533C	HSP31	1336	-374.5	4	Possible chaperone and cysteine protease with similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site [Source:SGD;Acc:S000002941]
D	YDR534C	FIT1	6	-2.2	2	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall [Source:SGD;Acc:S000002942]
D	YDR535C	YDR535C	5	-2.7	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YDR535C is not an essential gene. [Source:SGD;Acc:S000002943]
D	YDR536W	STL1	36	-57.5	4	Glycerol proton symporter of the plasma membrane, subject to glucose-induced inactivation, strongly but transiently induced when cells are subjected to osmotic shock [Source:SGD;Acc:S000002944]
D	YDR537C	YDR537C	5	-3	2	Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W [Source:SGD;Acc:S000002945]
D	YDR538W	PAD1	122	-91.6	4	Phenylacrylic acid decarboxylase, confers resistance to cinnamic acid, decarboxylates aromatic carboxylic acids to the corresponding vinyl derivatives; also has mRNA binding activity; homolog of E. coli UbiX [Source:SGD;Acc:S000002946]
D	YDR539W	FDC1	536	-331	4	Putative phenylacrylic acid decarboxylase; essential for the decarboxylation of aromatic carboxylic acids to the corresponding vinyl derivatives; homolog of E. coli UbiD; GFP-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000002947]
D	YDR540C	IRC4	15	-51.4	4	Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000002948]
D	YDR541C	YDR541C	88	-73.2	4	Putative dihydrokaempferol 4-reductase [Source:SGD;Acc:S000002949]
D	YDR542W	PAU10	5	-1.1	1	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions [Source:SGD;Acc:S000002950]
D	YDR543C	YDR543C	1	-1.6	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002951]
D	YDR544C	YDR544C	1	-1.4	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002952]
D	YDR545C-A	YDR545C-A	1	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YRF1-1/YDR545W [Source:SGD;Acc:S000028617]
D	YDR545W	YRF1-1	432	-490.2	4	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000002953]
E	YEL001C	IRC22	400	-117.3	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000000727]
E	YEL002C	WBP1	1799	-424.2	4	Beta subunit of the oligosaccharyl transferase (OST) glycoprotein complex; required for N-linked glycosylation of proteins in the endoplasmic reticulum [Source:SGD;Acc:S000000728]
E	YEL003W	GIM4	410	-76.1	4	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it [Source:SGD;Acc:S000000729]
E	YEL004W	YEA4	11	-12.8	2	Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) transporter required for cell wall chitin synthesis; localized to the ER [Source:SGD;Acc:S000000730]
E	YEL005C	VAB2	46	-42.6	4	Protein with a potential role in vacuolar function, as suggested by its ability to bind Vac8p; likely member of BLOC complex involved in endosomal cargo sorting; Vab2p-GFP-fusion localizes to cytoplasm in punctate patter [Source:SGD;Acc:S000000731]
E	YEL006W	YEA6	81	-58.4	4	Putative mitochondrial NAD+ transporter, member of the mitochondrial carrier subfamily (see also YIA6); has putative human ortholog [Source:SGD;Acc:S000000732]
E	YEL007W	MIT1	692	-187	4	Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1 [Source:SGD;Acc:S000000733]
E	YEL008C-A	YEL008C-A	1	-1.4	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028618]
E	YEL008W	YEL008W	1	0	1	Hypothetical protein predicted to be involved in metabolism [Source:SGD;Acc:S000000734]
E	YEL009C	GCN4	132	-85.2	4	Basic leucine zipper (bZIP) transcriptional activator of amino acid biosynthetic genes in response to amino acid starvation; expression is tightly regulated at both the transcriptional and translational levels [Source:SGD;Acc:S000000735]
E	YEL009C-A	YEL009C-A	15	-14.1	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028741]
E	YEL010W	YEL010W	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000736]
E	YEL011W	GLC3	914	-844.5	4	Glycogen branching enzyme, involved in glycogen accumulation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000000737]
E	YEL012W	UBC8	221	-102.8	4	Ubiquitin-conjugating enzyme that negatively regulates gluconeogenesis by mediating the glucose-induced ubiquitination of fructose-1,6-bisphosphatase (FBPase); cytoplasmic enzyme that catalyzes the ubiquitination of histones in vitro [Source:SGD;Acc:S000000738]
E	YEL013W	VAC8	1658	-734.4	4	Phosphorylated and palmitoylated vacuolar membrane protein that interacts with Atg13p, required for the cytoplasm-to-vacuole targeting (Cvt) pathway; interacts with Nvj1p to form nucleus-vacuole junctions [Source:SGD;Acc:S000000739]
E	YEL014C	YEL014C	2	-0.9	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000740]
E	YEL015W	EDC3	1076	-350.3	4	Non-essential conserved protein of unknown function, plays a role in mRNA decapping by specifically affecting the function of the decapping enzyme Dcp1p; localizes to cytoplasmic mRNA processing bodies [Source:SGD;Acc:S000000741]
E	YEL016C	NPP2	20	-11.8	2	Nucleotide pyrophosphatase/phosphodiesterase family member; mediates extracellular nucleotide phosphate hydrolysis along with Npp1p and Pho5p; activity and expression enhanced during conditions of phosphate starvation [Source:SGD;Acc:S000000742]
E	YEL017C-A	PMP2	2	-2.5	2	Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; nearly identical to PMP1 [Source:SGD;Acc:S000002103]
E	YEL017W	GTT3	488	-285.1	4	Protein of unknown function with a possible role in glutathione metabolism, as suggested by computational analysis of large-scale protein-protein interaction data; GFP-fusion protein localizes to the nuclear periphery [Source:SGD;Acc:S000000743]
E	YEL018C-A	YEL018C-A	10	-2.3	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028742]
E	YEL018W	EAF5	205	-95.8	4	Esa1p-associated factor, non-essential subunit of the NuA4 acetyltransferase complex [Source:SGD;Acc:S000000744]
E	YEL019C	MMS21	62	-39.4	4	SUMO ligase and component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; mutants are sensitive to methyl methanesulfonate and   ncreased spontaneous mutation and mitotic recombination [Source:SGD;Acc:S000000745]
E	YEL020C	YEL020C	345	-260.6	4	Hypothetical protein with low sequence identity to Pdc1p [Source:SGD;Acc:S000000746]
E	YEL020C-B	YEL020C-B	0	nf	1	Dubious open reading frame unlikely to encode a protein; partially overlaps verified gene YEL020W-A; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028544]
E	YEL020W-A	TIM9	1176	-272.6	4	Essential protein of the mitochondrial intermembrane space, forms a complex with Tim10p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane [Source:SGD;Acc:S000007256]
E	YEL021W	URA3	985	-413.7	4	Orotidine-5'-phosphate (OMP) decarboxylase, catalyzes the sixth enzymatic step in the de novo biosynthesis of pyrimidines, converting OMP into uridine monophosphate (UMP); converts 5-FOA into 5-fluorouracil, a toxic compound [Source:SGD;Acc:S000000747]
E	YEL022W	GEA2	1085	-911.6	4	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea1p [Source:SGD;Acc:S000000748]
E	YEL023C	YEL023C	12	-2.4	2	Putative protein of unknown function; expression is increased greatly during sporulation; YEL023C is not an essential gene [Source:SGD;Acc:S000000749]
E	YEL024W	RIP1	1143	-487	4	Ubiquinol-cytochrome-c reductase, a Rieske iron-sulfur protein of the mitochondrial cytochrome bc1 complex; transfers electrons from ubiquinol to cytochrome c1 during respiration [Source:SGD;Acc:S000000750]
E	YEL025C	YEL025C	33	-61.8	2	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000000751]
E	YEL026W	SNU13	2265	-311.8	4	RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein [Source:SGD;Acc:S000000752]
E	YEL027W	VMA3	312	-126.2	4	Proteolipid subunit of the vacuolar H(+)-ATPase V0 sector (subunit c; dicyclohexylcarbodiimide binding subunit); required for vacuolar acidification and important for copper and iron metal ion homeostasis [Source:SGD;Acc:S000000753]
E	YEL028W	YEL028W	6	-9.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000754]
E	YEL029C	BUD16	129	-106	4	Putative pyridoxal kinase, a key enzyme involved in pyridoxal 5'-phosphate synthesis, the active form of vitamin B6; required for genome integrity; involved in bud-site selection; similarity to yeast BUD17 and human pyridoxal kinase (PDXK) [Source:SGD;Acc:S000000755]
E	YEL030C-A	YEL030C-A	2	-1.2	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028619]
E	YEL030W	ECM10	3566	-540.5	4	Heat shock protein of the Hsp70 family, localized in mitochondrial nucleoids, plays a role in protein translocation, interacts with Mge1p in an ATP-dependent manner; overexpression induces extensive mitochondrial DNA aggregations [Source:SGD;Acc:S000000756]
E	YEL031W	SPF1	2539	-979.1	4	P-type ATPase, ion transporter of the ER membrane involved in ER function and Ca2+ homeostasis; required for regulating Hmg2p degradation; confers sensitivity to a killer toxin (SMKT) produced by Pichia farinosa KK1 [Source:SGD;Acc:S000000757]
E	YEL032C-A	YEL032C-A	0	nf	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028620]
E	YEL032W	MCM3	1344	-855.9	4	Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex [Source:SGD;Acc:S000000758]
E	YEL033W	MTC7	4	-1.1	1	Predicted metabolic role based on network analysis derived from ChIP experiments, a large-scale deletion study and localization of transcription factor binding sites; null mutant is sensitive to temperature oscillation in a cdc13-1 mutant [Source:SGD;Acc:S000000759]
E	YEL034C-A	YEL034C-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; completely overlaps HYP2/YEL034W, a verified gene that encodes eiF-5A [Source:SGD;Acc:S000028743]
E	YEL034W	HYP2	4202	-740.2	4	Translation elongation factor eIF-5A that may function in translation initiation; similar to and functionally redundant with Anb1p; structural homolog of bacterial EF-P; undergoes an essential hypusination modification [Source:SGD;Acc:S000000760]
E	YEL035C	UTR5	6	-1.4	1	Protein of unknown function; transcription may be regulated by Gcr1p; essential for growth under standard (aerobic) conditions but not under anaerobic conditions [Source:SGD;Acc:S000000761]
E	YEL036C	ANP1	652	-265.1	4	Subunit of the alpha-1,6 mannosyltransferase complex; type II membrane protein; has a role in retention of glycosyltransferases in the Golgi; involved in osmotic sensitivity and resistance to aminonitrophenyl propanediol [Source:SGD;Acc:S000000762]
E	YEL037C	RAD23	2040	-411.8	4	Protein with ubiquitin-like N terminus, subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover [Source:SGD;Acc:S000000763]
E	YEL038W	UTR4	971	-145.5	4	Protein with sequence similarity to 2,3-diketo-5-methylthiopentyl-1-phosphate enolase-phosphatases, involved in methionine salvage; found in both the cytoplasm and nucleus [Source:SGD;Acc:S000000764]
E	YEL039C	CYC7	957	-165.9	4	Cytochrome c isoform 2, expressed under hypoxic conditions; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration [Source:SGD;Acc:S000000765]
E	YEL040W	UTR2	847	-107	4	Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar to and functionally redundant with Crh1; glycosylphosphatidylinositol (GPI)-anchored protein localized to bud neck [Source:SGD;Acc:S000000766]
E	YEL041W	YEF1	38	-114.7	4	ATP-NADH kinase; phosphorylates both NAD and NADH; homooctameric structure consisting of 60-kDa subunits; sequence similarity to Utr1p and Pos5p; overexpression complements certain pos5 phenotypes [Source:SGD;Acc:S000000767]
E	YEL042W	GDA1	1379	-403.3	4	Guanosine diphosphatase located in the Golgi, involved in the transport of GDP-mannose into the Golgi lumen by converting GDP to GMP after mannose is transferred its substrate [Source:SGD;Acc:S000000768]
E	YEL043W	YEL043W	736	-269.9	4	Predicted cytoskeleton protein involved in intracellular signalling based on quantitative analysis of protein-protein interaction maps; may interact with ribosomes, based on co-purification studies; contains fibronectin type III domain fold [Source:SGD;Acc:S000000769]
E	YEL044W	IES6	284	-432.9	4	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; human ortholog INO80C is a member of the human INO80 complex; implicated in DNA repair based on genetic interactions with RAD52 epistasis genes [Source:SGD;Acc:S000000770]
E	YEL045C	YEL045C	6	-1.9	1	Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; deletion gives MMS sensitivity, growth defect under alkaline conditions, less than optimal growth upon citric acid stress [Source:SGD;Acc:S000000771]
E	YEL046C	GLY1	2988	-666.2	4	Threonine aldolase, catalyzes the cleavage of L-allo-threonine and L-threonine to glycine; involved in glycine biosynthesis [Source:SGD;Acc:S000000772]
E	YEL047C	FRD1	2318	-700.8	4	Soluble fumarate reductase, required with isoenzyme Osm1p for anaerobic growth; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000773]
E	YEL048C	TCA17	78	-55.2	4	Subunit of TRAPPII, a multimeric GEF involved in intra-Golgi and endosome-to-Golgi transport; promotes association of TRAPPII-specific subunits with the core complex; sedlin related; human Sedlin mutations cause SEDT, a skeletal disorder [Source:SGD;Acc:S000000774]
E	YEL049W	PAU2	2	-1.1	1	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme [Source:SGD;Acc:S000000775]
E	YEL050C	RML2	405	-176.5	4	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor [Source:SGD;Acc:S000000776]
E	YEL050W-A	YEL050W-A	2	-1.4	1	Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028545]
E	YEL051W	VMA8	1370	-352.5	4	Subunit D of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; plays a role in the coupling of proton transport and ATP hydrolysis [Source:SGD;Acc:S000000777]
E	YEL052W	AFG1	563	-331.4	4	Conserved protein that may act as a chaperone in the degradation of misfolded or unassembled cytochrome c oxidase subunits; localized to matrix face of the mitochondrial inner membrane; member of the AAA family but lacks a protease domain [Source:SGD;Acc:S000000778]
E	YEL053C	MAK10	218	-212.1	4	Non-catalytic subunit of N-terminal acetyltransferase of the NatC type, required for replication of dsRNA virus; expression is glucose-repressible [Source:SGD;Acc:S000000779]
E	YEL053W-A	YEL053W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YEL054C [Source:SGD;Acc:S000028744]
E	YEL054C	RPL12A	4915	-458.3	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl12Bp; rpl12a rpl12b double mutant exhibits slow growth and slow translation; has similarity to E. coli L11 and rat L12 ribosomal proteins [Source:SGD;Acc:S000000780]
E	YEL055C	POL5	1478	-557.3	4	DNA Polymerase phi; has sequence similarity to the human MybBP1A and weak sequence similarity to B-type DNA polymerases, not required for chromosomal DNA replication; required for the synthesis of rRNA [Source:SGD;Acc:S000000781]
E	YEL056W	HAT2	549	-1130.8	4	Subunit of the Hat1p-Hat2p histone acetyltransferase complex; required for high affinity binding of the complex to free histone H4, thereby enhancing Hat1p activity; similar to human RbAp46 and 48; has a role in telomeric silencing [Source:SGD;Acc:S000000782]
E	YEL057C	YEL057C	8	-1.9	1	Protein of unknown function involved in telomere maintenance; target of UME6 regulation [Source:SGD;Acc:S000000783]
E	YEL058W	PCM1	1527	-608.7	4	Essential N-acetylglucosamine-phosphate mutase; converts GlcNAc-6-P to GlcNAc-1-P, which is a precursor for the biosynthesis of chitin and for the formation of N-glycosylated mannoproteins and glycosylphosphatidylinositol anchors [Source:SGD;Acc:S000000784]
E	YEL059C-A	SOM1	51	-58.6	4	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000002954]
E	YEL059W	HHY1	1	-1	1	Dubious open reading frame unlikely to encode a functional protein; mutant is hypersensitive to hygromycin B indicative of defects in vacuolar trafficking [Source:SGD;Acc:S000000785]
E	YEL060C	PRB1	2034	-594.4	4	Vacuolar proteinase B (yscB), a serine protease of the subtilisin family; involved in protein degradation in the vacuole and required for full protein degradation during sporulation; activity inhibited by Pbi2p [Source:SGD;Acc:S000000786]
E	YEL061C	CIN8	256	-215.2	4	Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation [Source:SGD;Acc:S000000787]
E	YEL062W	NPR2	321	-210.5	4	Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex  p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; Iml1p interacts primarily with phosphorylated Npr2p; homolog of human NPRL2; target of Grr1p; required for growth on urea and proline [Source:SGD;Acc:S000000788]
E	YEL063C	CAN1	353	-99.1	4	Plasma membrane arginine permease, requires phosphatidyl ethanolamine (PE) for localization, exclusively associated with lipid rafts; mutation confers canavanine resistance [Source:SGD;Acc:S000000789]
E	YEL064C	AVT2	81	-37.2	4	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters [Source:SGD;Acc:S000000790]
E	YEL065W	SIT1	65	-67.9	4	Ferrioxamine B transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; transcription is induced during iron deprivation and diauxic shift; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000000791]
E	YEL066W	HPA3	268	-57.4	4	D-Amino acid N-acetyltransferase, catalyzes N-acetylation of D-amino acids through ordered bi-bi mechanism in which acetyl-CoA is first substrate bound and CoA is last product liberated; similar to Hpa2p, acetylates histones weakly in vitro [Source:SGD;Acc:S000000792]
E	YEL067C	YEL067C	9	-5.8	2	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000793]
E	YEL068C	YEL068C	9	-12.8	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000794]
E	YEL069C	HXT13	230	-25.7	2	Hexose transporter, induced in the presence of non-fermentable carbon sources, induced by low levels of glucose, repressed by high levels of glucose [Source:SGD;Acc:S000000795]
E	YEL070W	DSF1	116	-356.6	4	Deletion suppressor of mpt5 mutation [Source:SGD;Acc:S000000796]
E	YEL071W	DLD3	2691	-1074.7	4	D-lactate dehydrogenase, part of the retrograde regulon which consists of genes whose expression is stimulated by damage to mitochondria and reduced in cells grown with glutamate as the sole nitrogen source, located in the cytoplasm [Source:SGD;Acc:S000000797]
E	YEL072W	RMD6	6	-28.1	2	Protein required for sporulation [Source:SGD;Acc:S000000798]
E	YEL073C	YEL073C	15	-15.2	3	Putative protein of unknown function; located adjacent to ARS503 and the telomere on the left arm of chromosome V; regulated by inositol/choline [Source:SGD;Acc:S000000799]
E	YEL074W	YEL074W	1	-0.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large scale expression analysis showed an increase in mRNA accumulation in strains mutant for exosome components. [Source:SGD;Acc:S000000800]
E	YEL075C	YEL075C	64	-26	4	Putative protein of unknown function [Source:SGD;Acc:S000000801]
E	YEL075W-A	YEL075W-A	10	-2.7	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000002956]
E	YEL076C	YEL076C	71	-71.3	4	Putative protein of unknown function [Source:SGD;Acc:S000000802]
E	YEL076C-A	YEL076C-A	69	-54.1	4	Putative protein of unknown function [Source:SGD;Acc:S000002955]
E	YEL077C	YEL077C	313	-304.2	4	Helicase-like protein encoded within the telomeric Y' element [Source:SGD;Acc:S000006409]
E	YEL077W-A	YEL077W-A	1	-1.8	1	Dubious open reading frame, unlike to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028621]
E	YER001W	MNN1	790	-457.4	4	Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family [Source:SGD;Acc:S000000803]
E	YER002W	NOP16	786	-175.4	4	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis [Source:SGD;Acc:S000000804]
E	YER003C	PMI40	2361	-561.8	4	Mannose-6-phosphate isomerase, catalyzes the interconversion of fructose-6-P and mannose-6-P; required for early steps in protein mannosylation [Source:SGD;Acc:S000000805]
E	YER004W	FMP52	1056	-242.4	4	Protein of unknown function, localized to the mitochondrial outer membrane; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000000806]
E	YER005W	YND1	221	-172.7	4	Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity [Source:SGD;Acc:S000000807]
E	YER006C-A	YER006C-A	2	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PAC2 [Source:SGD;Acc:S000028745]
E	YER006W	NUG1	2363	-584.5	4	GTPase that associates with nuclear 60S pre-ribosomes, required for export of 60S ribosomal subunits from the nucleus [Source:SGD;Acc:S000000808]
E	YER007C-A	TMA20	1379	-152.5	4	Protein of unknown function that associates with ribosomes and has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1 [Source:SGD;Acc:S000002957]
E	YER007W	PAC2	37	-72.6	4	Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl [Source:SGD;Acc:S000000809]
E	YER008C	SEC3	1023	-806.6	4	Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, Exo84p) which mediates targeting of post-Golgi vesicles to sites of active exocytosis; Sec3p specifically is a spatial landmark for secretion [Source:SGD;Acc:S000000810]
E	YER009W	NTF2	1791	-323.1	4	Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport [Source:SGD;Acc:S000000811]
E	YER010C	YER010C	328	-69.8	4	Protein of unknown function, forms a ring-shaped homotrimer; has similarity to members of the prokaryotic rraA family; possibly involved in a phosphotransfer reaction [Source:SGD;Acc:S000000812]
E	YER011W	TIR1	24	-15.3	4	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expression is downregulated at acidic pH and induced by cold shock and anaerobiosis; abundance is increased in cells cultured without shaking [Source:SGD;Acc:S000000813]
E	YER012W	PRE1	1486	-164.2	4	Beta 4 subunit of the 20S proteasome; localizes to the nucleus throughout the cell cycle [Source:SGD;Acc:S000000814]
E	YER013W	PRP22	323	-421.5	4	DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes [Source:SGD;Acc:S000000815]
E	YER014C-A	BUD25	1	-1.1	1	Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern [Source:SGD;Acc:S000007590]
E	YER014W	HEM14	650	-435.6	4	Protoporphyrinogen oxidase, a mitochondrial enzyme that catalyzes the seventh step in the heme biosynthetic pathway, converting protoporphyrinogen IX to protoporphyrin IX; inhibited by diphenyl ether-type herbicides [Source:SGD;Acc:S000000816]
E	YER015W	FAA2	359	-390.6	4	Medium chain fatty acyl-CoA synthetase, activates imported fatty acids; accepts a wide range of fatty acid chain lengths with a preference for medium chains, C9:0-C13:0; localized to the peroxisome [Source:SGD;Acc:S000000817]
E	YER016W	BIM1	549	-206	4	Microtubule-binding protein that together with Kar9p makes up the cortical microtubule capture site and delays the exit from mitosis when the spindle is oriented abnormally [Source:SGD;Acc:S000000818]
E	YER017C	AFG3	717	-411.5	4	Component, with Yta12p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes [Source:SGD;Acc:S000000819]
E	YER018C	SPC25	178	-62	4	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering [Source:SGD;Acc:S000000820]
E	YER019C-A	SBH2	681	-56.1	4	Ssh1p-Sss1p-Sbh2p complex component, involved in protein translocation into the endoplasmic reticulum; homologous to Sbh1p [Source:SGD;Acc:S000002127]
E	YER019W	ISC1	362	-148.6	4	Mitochondrial membrane localized inositol phosphosphingolipid phospholipase C, hydrolyzes complex sphingolipids to produce ceramide; activated by phosphatidylserine, cardiolipin, and phosphatidylglycerol; mediates Na+ and Li+ halotolerance [Source:SGD;Acc:S000000821]
E	YER020W	GPA2	667	-453.3	4	Nucleotide binding alpha subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p, has signaling role in response to nutrients; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000000822]
E	YER021W	RPN3	1688	-547.5	4	Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control [Source:SGD;Acc:S000000823]
E	YER022W	SRB4	508	-372.6	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; homozygosity of the human MED17 L371P mutation is associated with infanti  ebral and cerebellar atrophy with poor myelination [Source:SGD;Acc:S000000824]
E	YER023C-A	YER023C-A	0	nf	1	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene PRO3; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028622]
E	YER023W	PRO3	2228	-384.3	4	Delta 1-pyrroline-5-carboxylate reductase, catalyzes the last step in proline biosynthesis [Source:SGD;Acc:S000000825]
E	YER024W	YAT2	490	-966.9	4	Carnitine acetyltransferase; has similarity to Yat1p, which is a carnitine acetyltransferase associated with the mitochondrial outer membrane [Source:SGD;Acc:S000000826]
E	YER025W	GCD11	3178	-574.1	4	Gamma subunit of the translation initiation factor eIF2, involved in the identification of the start codon; binds GTP when forming the ternary complex with GTP and tRNAi-Met [Source:SGD;Acc:S000000827]
E	YER026C	CHO1	1015	-291.5	4	Phosphatidylserine synthase, functions in phospholipid biosynthesis; catalyzes the reaction CDP-diaclyglycerol + L-serine = CMP + L-1-phosphatidylserine, transcriptionally repressed by myo-inositol and choline [Source:SGD;Acc:S000000828]
E	YER027C	GAL83	731	-936	4	One of three possible beta-subunits of the Snf1 kinase complex, allows nuclear localization of the Snf1 kinase complex in the presence of a nonfermentable carbon source; contains glycogen-binding domain [Source:SGD;Acc:S000000829]
E	YER028C	MIG3	26	-57.9	3	Probable transcriptional repressor involved in response to toxic agents such as hydroxyurea that inhibit ribonucleotide reductase; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes [Source:SGD;Acc:S000000830]
E	YER029C	SMB1	677	-197.2	4	Core Sm protein Sm B; part of heteroheptameric complex (with Smd1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm B and Sm B' [Source:SGD;Acc:S000000831]
E	YER030W	CHZ1	639	-249.3	4	Histone chaperone for Htz1p/H2A-H2B dimer; required for the stabilization of the Chz1p-Htz1-H2B complex; has overlapping function with Nap1p; null mutant displays weak sensitivity to MMS and benomyl; contains a highly conserved CHZ motif [Source:SGD;Acc:S000000832]
E	YER031C	YPT31	2184	-438.7	4	Rab family GTPase, very similar to Ypt32p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi [Source:SGD;Acc:S000000833]
E	YER032W	FIR1	188	-94.5	4	Protein involved in 3' mRNA processing, interacts with Ref2p; potential Cdc28p substrate [Source:SGD;Acc:S000000834]
E	YER033C	ZRG8	453	-123.7	4	Protein of unknown function; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; GFP-fusion protein is localized to the cytoplasm; transcription induced under conditions of zinc deficiency [Source:SGD;Acc:S000000835]
E	YER034W	YER034W	357	-125.1	4	Putative protein of unknown function; non-essential gene; expression induced upon calcium shortage [Source:SGD;Acc:S000000836]
E	YER035W	EDC2	9	-12.7	2	RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress [Source:SGD;Acc:S000000837]
E	YER036C	ARB1	3033	-742.4	4	ATPase of the ATP-binding cassette (ABC) family involved in 40S and 60S ribosome biogenesis, has similarity to Gcn20p; shuttles from nucleus to cytoplasm, physically interacts with Tif6p, Lsg1p [Source:SGD;Acc:S000000838]
E	YER037W	PHM8	47	-35.6	4	Lysophosphatidic acid (LPA) phosphatase involved in LPA hydrolysis in response to phosphate starvation; phosphatase activity is soluble and Mg2+ dependent; expression is induced by low phosphate levels and by inactivation of Pho85p [Source:SGD;Acc:S000000839]
E	YER038C	KRE29	77	-65.3	4	Subunit of the SMC5-SMC6 complex; this complex is involved in removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance [Source:SGD;Acc:S000000840]
E	YER038W-A	YER038W-A	3	-2	1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 99% of ORF overlaps the verified gene HVG1; protein product detected in mitochondria [Source:SGD;Acc:S000028746]
E	YER039C	HVG1	113	-26.1	4	Protein of unknown function, has homology to Vrg4p [Source:SGD;Acc:S000000841]
E	YER039C-A	YER039C-A	1	-2.4	2	Putative protein of unknown function; YER039C-A is not an essential gene [Source:SGD;Acc:S000007226]
E	YER040W	GLN3	545	-228.2	4	Transcriptional activator of genes regulated by nitrogen catabolite repression (NCR), localization and activity regulated by quality of nitrogen source [Source:SGD;Acc:S000000842]
E	YER041W	YEN1	86	-119.9	4	Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p [Source:SGD;Acc:S000000843]
E	YER042W	MXR1	976	-211.3	4	Methionine-S-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR2; involved in the regulation of lifespan [Source:SGD;Acc:S000000844]
E	YER043C	SAH1	4432	-1677.3	4	S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor [Source:SGD;Acc:S000000845]
E	YER044C	ERG28	751	-73.5	4	Endoplasmic reticulum membrane protein, may facilitate protein-protein interactions between the Erg26p dehydrogenase and the Erg27p 3-ketoreductase and/or tether these enzymes to the ER, also interacts with Erg6p [Source:SGD;Acc:S000000846]
E	YER044C-A	MEI4	4	-2.3	2	Meiosis-specific protein involved in double-strand break formation during meiotic recombination; required for chromosome synapsis and production of viable spores [Source:SGD;Acc:S000001954]
E	YER045C	ACA1	17	-27.8	4	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, may regulate transcription of genes involved in utilization of non-optimal carbon sources [Source:SGD;Acc:S000000847]
E	YER046W	SPO73	39	-42.8	4	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensible for both nuclear divisions during meiosis [Source:SGD;Acc:S000000848]
E	YER046W-A	YER046W-A	1	-2.6	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028747]
E	YER047C	SAP1	423	-369.1	4	Putative ATPase of the AAA family, interacts with the Sin1p transcriptional repressor in the two-hybrid system [Source:SGD;Acc:S000000849]
E	YER048C	CAJ1	1683	-544.2	4	Nuclear type II J heat shock protein of the E. coli dnaJ family, contains a leucine zipper-like motif, binds to non-native substrates for presentation to Ssa3p, may function during protein translocation, assembly and disassembly [Source:SGD;Acc:S000000850]
E	YER048W-A	ISD11	678	-116	4	Cysteine desulfurase (Nfs1p) activator; essential for the formation of the persulfide intermediate at the desulfurase active site during pyridoxal phosphate-dependent desulfuration of cysteine; required for mitochondrial iron-sulfur cluster biosynthesis [Source:SGD;Acc:S000007237]
E	YER049W	TPA1	1592	-601.3	4	Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate [Source:SGD;Acc:S000000851]
E	YER050C	RSM18	246	-65.8	4	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein [Source:SGD;Acc:S000000852]
E	YER051W	JHD1	38	-52.3	4	JmjC domain family histone demethylase specific for H3-K36, similar to proteins found in human, mouse, drosophila, X. laevis, C. elegans, and S. pombe [Source:SGD;Acc:S000000853]
E	YER052C	HOM3	2240	-678.6	4	Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis [Source:SGD;Acc:S000000854]
E	YER053C	PIC2	426	-215	4	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Mir1p but less abundant than Mir1p under normal conditions; expression is induced at high temperature [Source:SGD;Acc:S000000855]
E	YER053C-A	YER053C-A	2	-2.8	2	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum [Source:SGD;Acc:S000007523]
E	YER054C	GIP2	395	-284.4	4	Putative regulatory subunit of the protein phosphatase Glc7p, involved in glycogen metabolism; contains a conserved motif (GVNK motif) that is also found in Gac1p, Pig1p, and Pig2p [Source:SGD;Acc:S000000856]
E	YER055C	HIS1	2328	-473.5	4	ATP phosphoribosyltransferase, a hexameric enzyme, catalyzes the first step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control [Source:SGD;Acc:S000000857]
E	YER056C	FCY2	508	-113.6	4	Purine-cytosine permease, mediates purine (adenine, guanine, and hypoxanthine) and cytosine accumulation [Source:SGD;Acc:S000000858]
E	YER056C-A	RPL34A	2859	-281	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Bp and has similarity to rat L34 ribosomal protein [Source:SGD;Acc:S000002135]
E	YER057C	HMF1	1976	-302.2	4	Member of the p14.5 protein family with similarity to Mmf1p, functionally complements Mmf1p function when targeted to mitochondria; heat shock inducible; high-dosage growth inhibitor; forms a homotrimer in vitro [Source:SGD;Acc:S000000859]
E	YER058W	PET117	159	-112.7	4	Protein required for assembly of cytochrome c oxidase [Source:SGD;Acc:S000000860]
E	YER059W	PCL6	500	-787.9	4	Pho85p cyclin of the Pho80p subfamily; forms the major Glc8p kinase together with Pcl7p and Pho85p; involved in the control of glycogen storage by Pho85p; stabilized by Elongin C binding [Source:SGD;Acc:S000000861]
E	YER060W	FCY21	60	-24.5	4	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function [Source:SGD;Acc:S000000862]
E	YER060W-A	FCY22	8	-13.3	2	Putative purine-cytosine permease, very similar to Fcy2p but cannot substitute for its function [Source:SGD;Acc:S000002958]
E	YER061C	CEM1	421	-296.9	4	Mitochondrial beta-keto-acyl synthase with possible role in fatty acid synthesis; required for mitochondrial respiration [Source:SGD;Acc:S000000863]
E	YER062C	GPP2	3637	-374.5	4	One of two redundant DL-glycerol-3-phosphatases (RHR2/GPP1 encodes the other) involved in glycerol biosynthesis; induced in response to hyperosmotic stress and oxidative stress, and during the diauxic transition [Source:SGD;Acc:S000000864]
E	YER063W	THO1	1283	-308.3	4	Conserved nuclear RNA-binding protein; specifically binds to transcribed chromatin in a THO- and RNA-dependent manner, genetically interacts with shuttling hnRNP NAB2; overproduction suppresses transcriptional defect caused by hpr1 mutation [Source:SGD;Acc:S000000865]
E	YER064C	VHR2	184	-189.2	4	Non-essential nuclear protein; null mutation has global effects on transcription [Source:SGD;Acc:S000000866]
E	YER065C	ICL1	603	-1661.3	4	Isocitrate lyase, catalyzes the formation of succinate and glyoxylate from isocitrate, a key reaction of the glyoxylate cycle; expression of ICL1 is induced by growth on ethanol and repressed by growth on glucose [Source:SGD;Acc:S000000867]
E	YER066C-A	YER066C-A	4	-4.7	2	Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER067W [Source:SGD;Acc:S000002959]
E	YER066W	RRT13	7	-16.2	3	Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription [Source:SGD;Acc:S000000868]
E	YER067C-A	YER067C-A	9	-1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER067W [Source:SGD;Acc:S000028748]
E	YER067W	RGI1	812	-259.4	4	Protein of unknown function involved in energy metabolism under respiratory conditions; protein abundance is increased upon intracellular iron depletion [Source:SGD;Acc:S000000869]
E	YER068C-A	YER068C-A	1	-1.7	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028749]
E	YER068W	MOT2	1136	-306	4	Subunit of the CCR4-NOT complex, which has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p [Source:SGD;Acc:S000000870]
E	YER069W	ARG5,6	1667	-1056	4	ARG5,6, Protein that is processed in the mitochondrion to yield acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase, which catalyze the 2nd and 3rd steps in arginine biosynthesis; enzymes form a complex with Arg2p [Source:SGD;Acc:S000000871]
E	YER070W	RNR1	2415	-977.3	4	Major isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits [Source:SGD;Acc:S000000872]
E	YER071C	TDA2	166	-64	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele [Source:SGD;Acc:S000000873]
E	YER072W	VTC1	551	-72.8	4	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion; also has mRNA binding activity [Source:SGD;Acc:S000000874]
E	YER073W	ALD5	2154	-703.4	4	Mitochondrial aldehyde dehydrogenase, involved in regulation or biosynthesis of electron transport chain components and acetate formation; activated by K+; utilizes NADP+ as the preferred coenzyme; constitutively expressed [Source:SGD;Acc:S000000875]
E	YER074W	RPS24A	4154	-592	4	Protein component of the small (40S) ribosomal subunit; identical to Rps24Bp and has similarity to rat S24 ribosomal protein [Source:SGD;Acc:S000000876]
E	YER074W-A	YOS1	344	-45.2	4	Integral membrane protein required for ER to Golgi transport; localized to the Golgi, the ER, and COPII vesicles; interacts with Yip1p and Yif1p [Source:SGD;Acc:S000007651]
E	YER075C	PTP3	225	-905.4	4	Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the cytoplasm [Source:SGD;Acc:S000000877]
E	YER076C	YER076C	5	-3.7	2	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; analysis of HA-tagged protein suggests a membrane localization [Source:SGD;Acc:S000000878]
E	YER076W-A	YER076W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YER076C [Source:SGD;Acc:S000028750]
E	YER077C	YER077C	145	-191.8	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport [Source:SGD;Acc:S000000879]
E	YER078C	ICP55	306	-199.8	4	Mitochondrial aminopeptidase; cleaves the N termini of at least 38 imported proteins after cleavage by the mitochondrial processing peptidase (MPP), thereby increasing their stability; member of the aminopeptidase P family [Source:SGD;Acc:S000000880]
E	YER078W-A	YER078W-A	1	-1.3	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028546]
E	YER079C-A	YER079C-A	1	-6.6	2	Dubious open reading frame unlikely to encode a protein, partially overlaps uncharacterized ORF YER080W [Source:SGD;Acc:S000028751]
E	YER079W	YER079W	549	-142	4	Putative protein of unknown function [Source:SGD;Acc:S000000881]
E	YER080W	AIM9	1558	-607.5	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000000882]
E	YER081W	SER3	2295	-837.1	4	3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser33p [Source:SGD;Acc:S000000883]
E	YER082C	UTP7	1215	-241.2	4	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [Source:SGD;Acc:S000000884]
E	YER083C	GET2	950	-168.6	4	Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for meiotic nuclear division [Source:SGD;Acc:S000000885]
E	YER084W	YER084W	10	-11	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000886]
E	YER084W-A	YER084W-A	2	-5.4	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028752]
E	YER085C	YER085C	3	-1	1	Putative protein of unknown function [Source:SGD;Acc:S000000887]
E	YER086W	ILV1	2522	-770.8	4	Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation [Source:SGD;Acc:S000000888]
E	YER087C-A	YER087C-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; overlaps the uncharacterized gene YER087W, a putative tRNA synthetase [Source:SGD;Acc:S000028753]
E	YER087C-B	SBH1	581	-45.1	4	Beta subunit of the Sec61p ER translocation complex (Sec61p-Sss1p-Sbh1p); involved in protein translocation into the endoplasmic reticulum; interacts with the exocyst complex and also with Rtn1p; homologous to Sbh2p [Source:SGD;Acc:S000002128]
E	YER087W	AIM10	478	-339.6	4	Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000000889]
E	YER088C	DOT6	1068	-342.8	4	Protein involved in rRNA and ribosome biogenesis; binds polymerase A and C motif; subunit of the RPD3L histone deacetylase complex; similar to Tod6p; has chromatin specific SANT domain; involved in telomeric gene silencing and filamentation [Source:SGD;Acc:S000000890]
E	YER088C-A	YER088C-A	74	-14.7	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028754]
E	YER088W-B	YER088W-B	1	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the ORF PTC2/YER089C; identified by gene-trapping, expression analysis, and homology searching [Source:SGD;Acc:S000028623]
E	YER089C	PTC2	1427	-753.1	4	Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p to limit maximal osmostress induced kinase activity; dephosphorylates Ire1p to downregulate the unfolded protein response; dephosphorylates Cdc28p; inactivates the DNA damage checkpoint [Source:SGD;Acc:S000000891]
E	YER090C-A	YER090C-A	5	-1.1	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000029725]
E	YER090W	TRP2	2253	-552.5	4	Anthranilate synthase, catalyzes the initial step of tryptophan biosynthesis, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp3p [Source:SGD;Acc:S000000892]
E	YER091C	MET6	4156	-2018.5	4	Cobalamin-independent methionine synthase, involved in methionine biosynthesis and regeneration; requires a minimum of two glutamates on the methyltetrahydrofolate substrate, similar to bacterial metE homologs [Source:SGD;Acc:S000000893]
E	YER091C-A	YER091C-A	5	-3.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007238]
E	YER092W	IES5	233	-526.8	4	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions [Source:SGD;Acc:S000000894]
E	YER093C	TSC11	330	-250.3	4	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p), a membrane-associated complex that regulates actin cytoskeletal dynamics during polarized growth and cell wall integrity; involved in sphingolipid metabolism; contains a RasGEFN domain [Source:SGD;Acc:S000000895]
E	YER093C-A	AIM11	89	-47.6	4	Protein of unknown function; null mutant is viable but shows increased loss of mitochondrial genome and synthetic interaction with prohibitin (phb1); contains an intron [Source:SGD;Acc:S000002960]
E	YER094C	PUP3	1636	-194.5	4	Beta 3 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit C10 [Source:SGD;Acc:S000000896]
E	YER095W	RAD51	368	-973.9	4	Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein [Source:SGD;Acc:S000000897]
E	YER096W	SHC1	26	-11.6	2	Sporulation-specific activator of Chs3p (chitin synthase III), required for the synthesis of the chitosan layer of ascospores; has similarity to Skt5p, which activates Chs3p during vegetative growth; transcriptionally induced at alkaline pH [Source:SGD;Acc:S000000898]
E	YER097W	YER097W	6	-2.4	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000000899]
E	YER098W	UBP9	131	-109	4	Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease that cleaves ubiquitin-protein fusions [Source:SGD;Acc:S000000900]
E	YER099C	PRS2	904	-297.3	4	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes [Source:SGD;Acc:S000000901]
E	YER100W	UBC6	589	-150.5	4	Ubiquitin-conjugating enzyme involved in ER-associated protein degradation; located at the cytosolic side of the ER membrane; tail region contains a transmembrane segment at the C-terminus; substrate of the ubiquitin-proteasome pathway [Source:SGD;Acc:S000000902]
E	YER101C	AST2	368	-229.3	4	Protein that may have a role in targeting of plasma membrane [H+]ATPase (Pma1p) to the plasma membrane, as suggested by analysis of genetic interactions [Source:SGD;Acc:S000000903]
E	YER102W	RPS8B	4280	-680.1	4	Protein component of the small (40S) ribosomal subunit; identical to Rps8Ap and has similarity to rat S8 ribosomal protein [Source:SGD;Acc:S000000904]
E	YER103W	SSA4	6796	-1972.9	4	Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation [Source:SGD;Acc:S000000905]
E	YER104W	RTT105	47	-35.6	3	Protein with a role in regulation of Ty1 transposition [Source:SGD;Acc:S000000906]
E	YER105C	NUP157	1238	-1484.5	4	Abundant subunit of the nuclear pore complex (NPC), present on both sides of the NPC; has similarity to Nup170p; essential role, with Nup170p, in NPC assembly [Source:SGD;Acc:S000000907]
E	YER106W	MAM1	8	-10.6	2	Monopolin, kinetochore associated protein involved in chromosome attachment to meiotic spindle [Source:SGD;Acc:S000000908]
E	YER107C	GLE2	1021	-447.2	4	Component of the Nup82 subcomplex of the nuclear pore complex; required for polyadenylated RNA export but not for protein import; homologous to S. pombe Rae1p [Source:SGD;Acc:S000000909]
E	YER107W-A	YER107W-A	6	-1.8	1	Dubious open reading frame unlikely to encode a protein, partially overlaps verified ORF GLE2/YER107C [Source:SGD;Acc:S000028755]
E	YER109C	FLO8	77	-61.7	4	Transcription factor required for flocculation, diploid filamentous growth, and haploid invasive growth; genome reference strain S288C and most laboratory strains have a mutation in this gene [Source:SGD;Acc:S000000911]
E	YER110C	KAP123	3645	-1898.6	4	Karyopherin beta, mediates nuclear import of ribosomal proteins prior to assembly into ribosomes and import of histones H3 and H4; localizes to the nuclear pore, nucleus, and cytoplasm; exhibits genetic interactions with RAI1 [Source:SGD;Acc:S000000912]
E	YER111C	SWI4	562	-580.2	4	DNA binding component of the SBF complex (Swi4p-Swi6p), a transcriptional activator that in concert with MBF (Mbp1-Swi6p) regulates late G1-specific transcription of targets including cyclins and genes required for DNA synthesis and repair [Source:SGD;Acc:S000000913]
E	YER112W	LSM4	1159	-212.7	4	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA [Source:SGD;Acc:S000000914]
E	YER113C	TMN3	241	-160	4	Protein with a role in cellular adhesion and filamentous growth; similar to Emp70p and Tmn2p; member of Transmembrane Nine family with 9 transmembrane segments; localizes to Golgi; induced by 8-methoxypsoralen plus UVA irradiation [Source:SGD;Acc:S000000915]
E	YER114C	BOI2	1214	-478.4	4	Protein implicated in polar growth, functionally redundant with Boi1p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain [Source:SGD;Acc:S000000916]
E	YER115C	SPR6	8	-2.4	2	Protein of unknown function, expressed during sporulation; not required for sporulation, but gene exhibits genetic interactions with other genes required for sporulation [Source:SGD;Acc:S000000917]
E	YER116C	SLX8	158	-29.5	4	Subunit of the Slx5-Slx8 SUMO-targeted ubiquitin ligase (STUbL) complex; stimulated by prior attachment of SUMO to the substrate; contains a C-terminal RING domain [Source:SGD;Acc:S000000918]
E	YER117W	RPL23B	3793	-481.5	4	Protein component of the large (60S) ribosomal subunit, identical to Rpl23Ap and has similarity to E. coli L14 and rat L23 ribosomal proteins [Source:SGD;Acc:S000000919]
E	YER118C	SHO1	199	-71.7	4	Transmembrane osmosensor involved in activation of the Cdc42p- and MAP kinase-dependent filamentous growth pathway and the high-osmolarity glycerol response pathway; phosphorylated by Hog1p; interacts with Pbs2p, Msb2p, Hkr1p, and Ste11p [Source:SGD;Acc:S000000920]
E	YER119C	AVT6	95	-90	4	Vacuolar aspartate and glutamate exporter; member of a family of seven genes (AVT1-7) related to vesicular GABA-glycine transporters; involved in compartmentalizing acidic amino acids in response to nitrogen starvation [Source:SGD;Acc:S000000921]
E	YER119C-A	YER119C-A	0	nf	1	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene SCS2 [Source:SGD;Acc:S000002961]
E	YER120W	SCS2	2652	-614.6	4	Integral ER membrane protein that regulates phospholipid metabolism via an interaction with the FFAT motif of Opi1p, also involved in telomeric silencing, disruption causes inositol auxotrophy above 34 degrees C, VAP homolog [Source:SGD;Acc:S000000922]
E	YER121W	YER121W	2	-5.4	2	Putative protein of unknown function; may be involved in phosphatase regulation and/or generation of precursor metabolites and energy [Source:SGD;Acc:S000000923]
E	YER122C	GLO3	1919	-479.2	4	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Gcs1p [Source:SGD;Acc:S000000924]
E	YER123W	YCK3	625	-1163.1	4	Palmitoylated, vacuolar membrane-localized casein kinase I isoform; negatively regulates vacuole fusion during hypertonic stress via phosphorylation of Vps41p; shares essential functions with Hrr25p; regulates vesicle fusion in AP-3 pathway [Source:SGD;Acc:S000000925]
E	YER124C	DSE1	130	-117.8	4	Daughter cell-specific protein, may regulate cross-talk between the mating and filamentation pathways; deletion affects cell separation after division and sensitivity to alpha-factor and drugs affecting the cell wall [Source:SGD;Acc:S000000926]
E	YER125W	RSP5	2142	-3538.2	4	E3 ubiquitin ligase of the NEDD4 family; involved in regulating many cellular processes including MVB sorting, heat shock response, transcription, endocytosis, and ribosome stability; human homolog is involved in Liddle syndrome; mutant tolerates an  dy; ubiquitylates Sec23p [Source:SGD;Acc:S000000927]
E	YER126C	NSA2	970	-187.1	4	Protein constituent of 66S pre-ribosomal particles, contributes to processing of the 27S pre-rRNA [Source:SGD;Acc:S000000928]
E	YER127W	LCP5	547	-175.7	4	Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus [Source:SGD;Acc:S000000929]
E	YER128W	VFA1	173	-68.7	4	Protein that interacts with Vps4p and has a role in vacuolar sorting; localizes to endosomes in a Vps4-dependent manner; overexpression causes canavanine sensitivity and confers a partial class D vacuole morphology [Source:SGD;Acc:S000000930]
E	YER129W	SAK1	414	-1443.7	4	Upstream serine/threonine kinase for the SNF1 complex; partially redundant with Elm1p and Tos3p; members of this family have functional orthology with LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome [Source:SGD;Acc:S000000931]
E	YER130C	COM2	24	-21.9	4	Protein of unknown function; transcription is regulated by Haa1p, Sok2p and Zap1p transcriptional activators; the C. Albicans homolog (MNL1) plays a role in adaptation to stress [Source:SGD;Acc:S000000932]
E	YER131W	RPS26B	3228	-334.8	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Ap and has similarity to rat S26 ribosomal protein [Source:SGD;Acc:S000000933]
E	YER132C	PMD1	474	-410.8	4	Protein with an N-terminal kelch-like domain, putative negative regulator of early meiotic gene expression; required, with Mds3p, for growth under alkaline conditions [Source:SGD;Acc:S000000934]
E	YER133W	GLC7	2442	-644.4	4	Type 1 serine/threonine protein phosphatase catalytic subunit, involved in many processes (eg: glycogen metabolism, sporulation, mitosis); accumulates at mating projections by interaction with Afr1p; interacts with many regulatory subunits [Source:SGD;Acc:S000000935]
E	YER133W-A	YER133W-A	1	-1.9	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YER134C. [Source:SGD;Acc:S000028756]
E	YER134C	YER134C	673	-141.6	4	Magnesium-dependent acid phosphatase, member of the haloacid dehalogenase superfamily; non-essential gene [Source:SGD;Acc:S000000936]
E	YER135C	YER135C	1	-1.2	1	Dubious open reading frame unlikely to encode a protein; YER135C is not an essential gene [Source:SGD;Acc:S000000937]
E	YER136W	GDI1	2082	-612.7	4	GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins [Source:SGD;Acc:S000000938]
E	YER137C	YER137C	67	-61.7	4	Putative protein of unknown function [Source:SGD;Acc:S000000939]
E	YER137C-A	YER137C-A	4727	-1742.3	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007402]
E	YER137W-A	YER137W-A	2	-2.1	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028757]
E	YER138C	YER138C	5029	-2523.1	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000000940]
E	YER138W-A	YER138W-A	4	-1.3	1	Putative protein of unknown function [Source:SGD;Acc:S000007239]
E	YER139C	RTR1	424	-162.1	4	CTD phosphatase; dephosphorylates S5-P in the C-terminal domain of Rpo21p; has a cysteine-rich motif required for function and conserved in eukaryotes; shuttles between the nucleus and cytoplasm [Source:SGD;Acc:S000000941]
E	YER140W	EMP65	58	-62.8	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; genetic interactions suggest a role in folding of ER membrane proteins [Source:SGD;Acc:S000000942]
E	YER141W	COX15	753	-228.2	4	Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase [Source:SGD;Acc:S000000943]
E	YER142C	MAG1	147	-204	4	3-methyl-adenine DNA glycosylase involved in protecting DNA against alkylating agents; initiates base excision repair by removing damaged bases to create abasic sites that are subsequently repaired [Source:SGD;Acc:S000000944]
E	YER143W	DDI1	1014	-376.5	4	DNA damage-inducible v-SNARE binding protein with a role in suppression of protein secretion; may play a role in S-phase checkpoint control; has ubiquitin-associated (UBA), ubiquitin-like (UBL), and retroviral-like proteinase (RVP) domains [Source:SGD;Acc:S000000945]
E	YER144C	UBP5	135	-182.1	4	Putative ubiquitin-specific protease, closest paralog of Doa4p but has no functional overlap; concentrates at the bud neck [Source:SGD;Acc:S000000946]
E	YER145C	FTR1	498	-107.8	4	High affinity iron permease involved in the transport of iron across the plasma membrane; forms complex with Fet3p; expression is regulated by iron [Source:SGD;Acc:S000000947]
E	YER145C-A	YER145C-A	5	-12	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF LSM5/YER146W [Source:SGD;Acc:S000028758]
E	YER146W	LSM5	1012	-104.1	4	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA [Source:SGD;Acc:S000000948]
E	YER147C	SCC4	102	-810.1	4	Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for the loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during double-strand break repair via phosphorylated histone H2AX [Source:SGD;Acc:S000000949]
E	YER147C-A	YER147C-A	5	-1.7	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028759]
E	YER148W	SPT15	616	-154	4	TATA-binding protein, general transcription factor that interacts with other factors to form the preinitiation complex at promoters, essential for viability [Source:SGD;Acc:S000000950]
E	YER148W-A	YER148W-A	2	-1.6	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028760]
E	YER149C	PEA2	630	-144.7	4	Coiled-coil polarisome protein required for polarized morphogenesis, cell fusion, and low affinity Ca2+ influx; forms polarisome complex with Bni1p, Bud6p, and Spa2p; localizes to sites of polarized growth [Source:SGD;Acc:S000000951]
E	YER150W	SPI1	12	-13.7	2	GPI-anchored cell wall protein involved in weak acid resistance; basal expression requires Msn2p/Msn4p; expression is induced under conditions of stress and during the diauxic shift; similar to Sed1p [Source:SGD;Acc:S000000952]
E	YER151C	UBP3	2001	-600.5	4	Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phospho  on at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity [Source:SGD;Acc:S000000953]
E	YER152C	YER152C	472	-271.4	4	Protein with 2-aminoadipate transaminase activity; shares amino acid similarity with the aminotransferases Aro8p and Aro9p; YER152C is not an essential gene [Source:SGD;Acc:S000000954]
E	YER152W-A	YER152W-A	8	-2.6	2	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028761]
E	YER153C	PET122	56	-100.9	4	Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet494p; located in the mitochondrial inner membrane [Source:SGD;Acc:S000000955]
E	YER154W	OXA1	465	-180.2	4	Mitochondrial inner membrane insertase, mediates the insertion of both mitochondrial- and nuclear-encoded proteins from the matrix into the inner membrane, interacts with mitochondrial ribosomes; conserved from bacteria to animals [Source:SGD;Acc:S000000956]
E	YER155C	BEM2	1955	-1480.9	4	Rho GTPase activating protein (RhoGAP) involved in the control of cytoskeleton organization and cellular morphogenesis; required for bud emergence [Source:SGD;Acc:S000000957]
E	YER156C	YER156C	1724	-295.4	4	Putative protein of unknown function; interacts with Hsp82p and copurifies with Ipl1p; expression is copper responsive and downregulated in strains deleted for MAC1, a copper-responsive transcription factor; similarity to mammalian MYG1 [Source:SGD;Acc:S000000958]
E	YER157W	COG3	479	-362.7	4	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000000959]
E	YER158C	YER158C	66	-86.2	4	Protein of unknown function, has similarity to Afr1p; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000000960]
E	YER158W-A	YER158W-A	2	-2.9	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028624]
E	YER159C	BUR6	570	-114	4	Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha [Source:SGD;Acc:S000000961]
E	YER159C-A	YER159C-A	4589	-1612.1	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007403]
E	YER160C	YER160C	4905	-2170.4	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000000962]
E	YER161C	SPT2	227	-119.8	4	Protein involved in negative regulation of transcription; required for RNA polyadenylation; exhibits regulated interactions with both histones and SWI-SNF components, has similarity to mammalian HMG1 proteins [Source:SGD;Acc:S000000963]
E	YER162C	RAD4	158	-197.7	4	Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins [Source:SGD;Acc:S000000964]
E	YER163C	GCG1	237	-77.2	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; periodically expressed during the metabolic cycle; weak similarity to bacterial cation transport protein [Source:SGD;Acc:S000000965]
E	YER164W	CHD1	1394	-1649.2	4	Chromatin remodeler that regulates various aspects of transcription; contains a chromo domain, a helicase domain and a DNA-binding domain; component of both the SAGA and SLIK complexes [Source:SGD;Acc:S000000966]
E	YER165C-A	YER165C-A	1	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DNF1/YER166W [Source:SGD;Acc:S000028762]
E	YER165W	PAB1	4692	-1211.2	4	Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G [Source:SGD;Acc:S000000967]
E	YER166W	DNF1	1094	-707.2	4	Aminophospholipid translocase (flippase) that localizes primarily to the plasma membrane; contributes to endocytosis, protein transport and cell polarity; type 4 P-type ATPase [Source:SGD;Acc:S000000968]
E	YER167W	BCK2	238	-1216.2	4	Protein rich in serine and threonine residues involved in protein kinase C signaling pathway, which controls cell integrity; overproduction suppresses pkc1 mutations [Source:SGD;Acc:S000000969]
E	YER168C	CCA1	753	-319.3	4	ATP (CTP):tRNA-specific tRNA nucleotidyltransferase; different forms targeted to the nucleus, cytosol, and mitochondrion are generated via the use of multiple transcriptional and translational start sites [Source:SGD;Acc:S000000970]
E	YER169W	RPH1	596	-345.9	4	JmjC domain-containing histone demethylase; specifically demethylates H3K36 tri- and dimethyl modification states; associates with actively transcribed (RNA polymerase II) regions in vivo and specifically targets H3K36 in its trimethylation state as  ubstrate; transcriptional repressor of PHR1; Rph1p phosphorylation during DNA damage is under control of the MEC1-RAD53 pathway [Source:SGD;Acc:S000000971]
E	YER170W	ADK2	105	-164.1	4	Mitochondrial adenylate kinase, catalyzes the reversible synthesis of GTP and AMP from GDP and ADP; may serve as a back-up for synthesizing GTP or ADP depending on metabolic conditions; 3' sequence of ADK2 varies with strain background [Source:SGD;Acc:S000000972]
E	YER171W	RAD3	354	-322.1	4	5' to 3' DNA helicase, involved in nucleotide excision repair and transcription; subunit of RNA polII initiation factor TFIIH and of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPD protein; mutant has aneuploidy tolerance [Source:SGD;Acc:S000000973]
E	YER172C	BRR2	727	-1015.7	4	RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD [Source:SGD;Acc:S000000974]
E	YER172C-A	YER172C-A	4	-1.4	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028763]
E	YER173W	RAD24	28	-47.2	4	Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; subunit of a clamp loader that loads Rad17p-Mec3p-Ddc1p onto DNA; homolog of human and S. pombe Rad17 protein [Source:SGD;Acc:S000000975]
E	YER174C	GRX4	1062	-126.8	4	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx3p and Grx5p; protects cells from oxidative damage; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000000976]
E	YER175C	TMT1	472	-211.8	4	Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle [Source:SGD;Acc:S000000977]
E	YER175W-A	YER175W-A	5	-8	4	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028625]
E	YER176W	ECM32	707	-401.4	4	DNA dependent ATPase/DNA helicase belonging to the Dna2p- and Nam7p-like family of helicases that is involved in modulating translation termination; interacts with the translation termination factors, localized to polysomes [Source:SGD;Acc:S000000978]
E	YER177W	BMH1	4656	-935.1	4	14-3-3 protein, major isoform; controls proteome at post-transcriptional level, binds proteins and DNA, involved in regulation of many processes including exocytosis, vesicle transport, Ras/MAPK signaling, and rapamycin-sensitive signaling [Source:SGD;Acc:S000000979]
E	YER178W	PDA1	3243	-1179.3	4	E1 alpha subunit of the pyruvate dehydrogenase (PDH) complex, catalyzes the direct oxidative decarboxylation of pyruvate to acetyl-CoA; phosphorylated; regulated by glucose [Source:SGD;Acc:S000000980]
E	YER179W	DMC1	38	-109.8	4	Meiosis-specific protein required for repair of double-strand breaks and pairing between homologous chromosomes; homolog of Rad51p and the bacterial RecA protein [Source:SGD;Acc:S000000981]
E	YER180C	ISC10	10	-2.1	2	Protein required for sporulation, transcript is induced 7.5 hours after induction of meiosis, expected to play significant role in the formation of reproductive cells [Source:SGD;Acc:S000000982]
E	YER180C-A	SLO1	276	-60.9	4	Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO [Source:SGD;Acc:S000028437]
E	YER181C	YER181C	36	-13.7	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative data; extensively overlaps a Ty1 LTR; protein product is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000983]
E	YER182W	FMP10	586	-201.4	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000000984]
E	YER183C	FAU1	267	-62.1	4	5,10-methenyltetrahydrofolate synthetase, involved in folic acid biosynthesis [Source:SGD;Acc:S000000985]
E	YER184C	TOG1	32	-11.8	2	Putative zinc cluster protein; deletion confers sensitivity to Calcufluor white, and prevents growth on glycerol or lactate as sole carbon source [Source:SGD;Acc:S000000986]
E	YER185W	PUG1	16	-5.9	3	Plasma membrane protein with roles in the uptake of protoprophyrin IX and the efflux of heme; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of proteins [Source:SGD;Acc:S000000987]
E	YER186C	YER186C	16	-36.2	2	Putative protein of unknown function [Source:SGD;Acc:S000000988]
E	YER187W	YER187W	7	-11.5	2	Putative protein of unknown function; induced in respiratory-deficient cells [Source:SGD;Acc:S000000989]
E	YER188C-A	YER188C-A	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000028764]
E	YER188W	YER188W	27	-28.3	4	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; large-scale analyses show mRNA expression increases under anaerobic conditions and two-hybrid interactions with Sst2p [Source:SGD;Acc:S000000990]
E	YER189W	YER189W	63	-26	4	Putative protein of unknown function [Source:SGD;Acc:S000000991]
E	YER190C-A	YER190C-A	14	-25.7	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YRF1-2/YER190W; identified by gene-trapping, expression analysis, and homology [Source:SGD;Acc:S000028626]
E	YER190C-B	YER190C-B	1	-1.8	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028627]
E	YER190W	YRF1-2	404	-417.5	4	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000000992]
F	YFL001W	DEG1	368	-246	4	tRNA:pseudouridine synthase, introduces pseudouridines at position 38 or 39 in tRNA, important for maintenance of translation efficiency and normal cell growth, localizes to both the nucleus and cytoplasm; non-essential for viability [Source:SGD;Acc:S000001895]
F	YFL002C	SPB4	590	-304.4	4	Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients [Source:SGD;Acc:S000001894]
F	YFL002W-A	YFL002W-A	2367	-922.5	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000002962]
F	YFL002W-B	YFL002W-B	1046	-394.9	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007404]
F	YFL003C	MSH4	23	-285	4	Protein involved in meiotic recombination, required for normal levels of crossing over, colocalizes with Zip2p to discrete foci on meiotic chromosomes, has homology to bacterial MutS protein [Source:SGD;Acc:S000001891]
F	YFL004W	VTC2	2188	-674.2	4	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion [Source:SGD;Acc:S000001890]
F	YFL005W	SEC4	2399	-322.1	4	Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane [Source:SGD;Acc:S000001889]
F	YFL007W	BLM10	1123	-972.8	4	Proteasome activator subunit; found in association with core particles, with and without the 19S regulatory particle; required for resistance to bleomycin, may be involved in protecting against oxidative damage; similar to mammalian PA200 [Source:SGD;Acc:S000001887]
F	YFL008W	SMC1	854	-621.3	4	Subunit of the multiprotein cohesin complex, essential protein involved in chromosome segregation and in double-strand DNA break repair; SMC chromosomal ATPase family member, binds DNA with a preference for DNA with secondary structure [Source:SGD;Acc:S000001886]
F	YFL009W	CDC4	267	-104.5	4	F-box protein required for G1/S and G2/M transition, associates with Skp1p and Cdc53p to form a complex, SCFCdc4, which acts as ubiquitin-protein ligase directing ubiquitination of the phosphorylated CDK inhibitor Sic1p [Source:SGD;Acc:S000001885]
F	YFL010C	WWM1	1388	-321.8	4	WW domain containing protein of unknown function; binds to Mca1p, a caspase-related protease that regulates H2O2-induced apoptosis; overexpression causes G1 phase growth arrest and clonal death that is suppressed by overexpression of MCA1 [Source:SGD;Acc:S000001884]
F	YFL010W-A	AUA1	1	-1.4	1	Protein required for the negative regulation by ammonia of Gap1p, which is a general amino acid permease [Source:SGD;Acc:S000001955]
F	YFL011W	HXT10	126	-33	3	Putative hexose transporter, expressed at low levels and expression is repressed by glucose [Source:SGD;Acc:S000001883]
F	YFL012W	YFL012W	1	-2.6	2	Putative protein of unknown function; transcribed during sporulation; null mutant exhibits increased resistance to rapamycin [Source:SGD;Acc:S000001882]
F	YFL012W-A	YFL012W-A	5	-18.9	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene IES1/YFL013C [Source:SGD;Acc:S000002964]
F	YFL013C	IES1	632	-1939.8	4	Subunit of the INO80 chromatin remodeling complex [Source:SGD;Acc:S000001881]
F	YFL013W-A	YFL013W-A	5	-2.7	2	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps IES1/YFL013C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028628]
F	YFL014W	HSP12	2470	-615.7	4	Plasma membrane protein involved in maintaining membrane organization in stress conditions; induced by heat shock, oxidative stress, osmostress, stationary phase, glucose depletion, oleate and alcohol; regulated by HOG and Ras-Pka pathways [Source:SGD;Acc:S000001880]
F	YFL015C	YFL015C	1	-1.2	1	Dubious open reading frame unlikely to encode a protein; partially overlaps dubious ORF YFL015W-A; YFL015C is not an essential gene [Source:SGD;Acc:S000001879]
F	YFL015W-A	YFL015W-A	9	-3.4	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028765]
F	YFL016C	MDJ1	1175	-522.9	4	Co-chaperone that stimulates the ATPase activity of the HSP70 protein Ssc1p; involved in protein folding/refolding in the mitochodrial matrix; required for proteolysis of misfolded proteins; member of the HSP40 (DnaJ) family of chaperones [Source:SGD;Acc:S000001878]
F	YFL017C	GNA1	894	-283.6	4	Evolutionarily conserved glucosamine-6-phosphate acetyltransferase required for multiple cell cycle events including passage through START, DNA synthesis, and mitosis; involved in UDP-N-acetylglucosamine synthesis, forms GlcNAc6P from AcCoA [Source:SGD;Acc:S000001877]
F	YFL017W-A	SMX2	97	-23	3	Core Sm protein Sm G; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx3p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm G [Source:SGD;Acc:S000002965]
F	YFL018C	LPD1	2585	-1343.8	4	Dihydrolipoamide dehydrogenase, the lipoamide dehydrogenase component (E3) of the pyruvate dehydrogenase and 2-oxoglutarate dehydrogenase multi-enzyme complexes [Source:SGD;Acc:S000001876]
F	YFL019C	YFL019C	8	-7	2	Dubious open reading frame unlikely to encode a protein; YFL019C is not an essential gene [Source:SGD;Acc:S000001875]
F	YFL020C	PAU5	7	-2.2	2	Member of the seripauperin multigene family encoded mainly in subtelomeric regions; induced during alcoholic fermentation; induced by low temperature and also by anaerobic conditions; negatively regulated by oxygen and repressed by heme [Source:SGD;Acc:S000001874]
F	YFL021C-A	YFL021C-A	23	-11.5	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028766]
F	YFL021W	GAT1	550	-175.1	4	Transcriptional activator of genes involved in nitrogen catabolite repression; contains a GATA-1-type zinc finger DNA-binding motif; activity and localization regulated by nitrogen limitation and Ure2p [Source:SGD;Acc:S000001873]
F	YFL022C	FRS2	2743	-874.8	4	Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar [Source:SGD;Acc:S000001872]
F	YFL023W	BUD27	819	-393.5	4	Unconventional prefoldin protein involved in translation initiation; mutants have inappropriate expression of nutrient sensitive genes due to translational derepression of Gcn4p transcription factor; diploid mutants show random budding [Source:SGD;Acc:S000001871]
F	YFL024C	EPL1	366	-463.3	4	Subunit of NuA4, an essential histone H4/H2A acetyltransferase complex; conserved region at N-terminus is essential for interaction with the NPC (nucleosome core particle); homologous to Drosophila Enhancer of Polycomb [Source:SGD;Acc:S000001870]
F	YFL025C	BST1	124	-132.2	4	GPI inositol deacylase of the ER that negatively regulates COPII vesicle formation, prevents production of vesicles with defective subunits, required for proper discrimination between resident ER proteins and Golgi-bound cargo molecules [Source:SGD;Acc:S000001869]
F	YFL026W	STE2	753	-168.3	4	Receptor for alpha-factor pheromone; seven transmembrane-domain GPCR that interacts with both pheromone and a heterotrimeric G protein to initiate the signaling response that leads to mating between haploid a and alpha cells [Source:SGD;Acc:S000001868]
F	YFL027C	GYP8	117	-140.7	4	GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport [Source:SGD;Acc:S000001867]
F	YFL028C	CAF16	931	-236.6	4	Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator [Source:SGD;Acc:S000001866]
F	YFL029C	CAK1	179	-669.6	4	Cyclin-dependent kinase-activating kinase required for passage through the cell cycle, phosphorylates and activates Cdc28p; nucleotide-binding pocket differs significantly from those of most other protein kinases [Source:SGD;Acc:S000001865]
F	YFL030W	AGX1	493	-717.6	4	Alanine:glyoxylate aminotransferase (AGT), catalyzes the synthesis of glycine from glyoxylate, which is one of three pathways for glycine biosynthesis in yeast; has similarity to mammalian and plant alanine:glyoxylate aminotransferases [Source:SGD;Acc:S000001864]
F	YFL031C-A	YFL031C-A	3	-1.4	1	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps HAC1/YFL031W; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028629]
F	YFL031W	HAC1	59	-29	4	Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog) that regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis [Source:SGD;Acc:S000001863]
F	YFL032W	YFL032W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HAC1/YFL031W; YFL032W is not an essential gene [Source:SGD;Acc:S000001862]
F	YFL033C	RIM15	697	-2312.7	4	Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase [Source:SGD;Acc:S000001861]
F	YFL034C-A	RPL22B	1467	-121.8	4	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Ap and to rat L22 ribosomal protein [Source:SGD;Acc:S000006436]
F	YFL034C-B	MOB2	395	-143.3	4	Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; simi   Mob1p [Source:SGD;Acc:S000001859]
F	YFL034W	YFL034W	382	-331.2	4	Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk [Source:SGD;Acc:S000001860]
F	YFL036W	RPO41	408	-509	4	Mitochondrial RNA polymerase; single subunit enzyme similar to those of T3 and T7 bacteriophages; requires a specificity subunit encoded by MTF1 for promoter recognition; binding of Mtf1p to the Rpo41p-promoter complex stabilizes the binding and ind  NA bending [Source:SGD;Acc:S000001858]
F	YFL037W	TUB2	3265	-566.8	4	Beta-tubulin; associates with alpha-tubulin (Tub1p and Tub3p) to form tubulin dimer, which polymerizes to form microtubules [Source:SGD;Acc:S000001857]
F	YFL038C	YPT1	2392	-428.4	4	Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p) [Source:SGD;Acc:S000001856]
F	YFL039C	ACT1	6040	-2370.9	4	Actin, structural protein involved in cell polarization, endocytosis, and other cytoskeletal functions [Source:SGD;Acc:S000001855]
F	YFL040W	YFL040W	5	-9.1	2	Putative transporter, member of the sugar porter family; YFL040W is not an essential gene [Source:SGD;Acc:S000001854]
F	YFL041W	FET5	681	-295.7	4	Multicopper oxidase, integral membrane protein with similarity to Fet3p; may have a role in iron transport [Source:SGD;Acc:S000001853]
F	YFL041W-A	YFL041W-A	3	-1.5	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028547]
F	YFL042C	YFL042C	462	-304.8	4	Putative protein of unknown function; YFL042C is not an essential gene [Source:SGD;Acc:S000001852]
F	YFL044C	OTU1	534	-205.8	4	Deubiquitylation enzyme that binds to the chaperone-ATPase Cdc48p; may contribute to regulation of protein degradation by deubiquitylating substrates that have been ubiquitylated by Ufd2p; member of the Ovarian Tumor (OTU) family [Source:SGD;Acc:S000001850]
F	YFL045C	SEC53	3347	-508	4	Phosphomannomutase, involved in synthesis of GDP-mannose and dolichol-phosphate-mannose; required for folding and glycosylation of secretory proteins in the ER lumen [Source:SGD;Acc:S000001849]
F	YFL046W	FMP32	102	-130.8	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001848]
F	YFL047W	RGD2	649	-346.9	4	GTPase-activating protein (RhoGAP) for Cdc42p and Rho5p [Source:SGD;Acc:S000001847]
F	YFL048C	EMP47	1375	-509.9	4	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport [Source:SGD;Acc:S000001846]
F	YFL049W	SWP82	303	-270.8	4	Member of the SWI/SNF chromatin remodeling complex in which it plays an as yet unidentified role; has identifiable counterparts in closely related yeast species; abundantly expressed in many growth conditions; paralog of Npl6p [Source:SGD;Acc:S000001845]
F	YFL050C	ALR2	164	-37.4	3	Probable Mg(2+) transporter; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions; plays a role in regulating Ty1 transposition [Source:SGD;Acc:S000001844]
F	YFL051C	YFL051C	0	nf	1	Putative protein of unknown function; YFL051C is not an essential gene [Source:SGD;Acc:S000001843]
F	YFL052W	YFL052W	19	-14.6	2	Putative zinc cluster protein that contains a DNA binding domain; null mutant sensitive to calcofluor white, low osmolarity and heat, suggesting a role for YFL052Wp in cell wall integrity [Source:SGD;Acc:S000001842]
F	YFL053W	DAK2	72	-1759.8	4	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation [Source:SGD;Acc:S000001841]
F	YFL054C	YFL054C	69	-44.7	4	Putative channel-like protein; similar to Fps1p; mediates passive diffusion of glycerol in the presence of ethanol [Source:SGD;Acc:S000001840]
F	YFL055W	AGP3	29	-8.8	2	Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition [Source:SGD;Acc:S000001839]
F	YFL056C	AAD6	21	-11.6	4	Putative aryl-alcohol dehydrogenase; involved in oxidative stress response; similar to P. chrysosporium aryl-alcohol dehydrogenase; expression induced in cells treated with the mycotoxin patulin [Source:SGD;Acc:S000001838]
F	YFL057C	AAD16	8	-17.5	2	Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role [Source:SGD;Acc:S000001837]
F	YFL058W	THI5	55	-139.4	4	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 [Source:SGD;Acc:S000001836]
F	YFL059W	SNZ3	488	-145.7	4	Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO3 [Source:SGD;Acc:S000001835]
F	YFL060C	SNO3	79	-51.6	4	Protein of unknown function, nearly identical to Sno2p; expression is induced before the diauxic shift and also in the absence of thiamin [Source:SGD;Acc:S000001834]
F	YFL061W	DDI2	17	-27.9	4	Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants [Source:SGD;Acc:S000001833]
F	YFL062W	COS4	217	-76.9	4	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000001832]
F	YFL063W	YFL063W	0	nf	1	Dubious open reading frame, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001831]
F	YFL064C	YFL064C	110	-61.9	4	Putative protein of unknown function [Source:SGD;Acc:S000001830]
F	YFL065C	YFL065C	51	-21.4	4	Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000001829]
F	YFL066C	YFL066C	182	-132.9	4	Helicase-like protein encoded within the telomeric Y' element; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000001828]
F	YFL067W	YFL067W	20	-15.6	2	Protein of unknown function, down-regulated at low calcium levels [Source:SGD;Acc:S000001827]
F	YFL068W	YFL068W	43	-1.6	1	Putative protein of unknown function [Source:SGD;Acc:S000001826]
F	YFR001W	LOC1	905	-170.8	4	Nuclear protein involved in asymmetric localization of ASH1 mRNA; binds double-stranded RNA in vitro; constituent of 66S pre-ribosomal particles [Source:SGD;Acc:S000001897]
F	YFR002W	NIC96	1348	-1282.7	4	Component of the nuclear pore complex, required for nuclear pore formation; forms a subcomplex with Nsp1p, Nup57p, and Nup49p [Source:SGD;Acc:S000001898]
F	YFR003C	YPI1	608	-156.4	4	Inhibitor of the type I protein phosphatase Glc7p, which is involved in regulation of a variety of metabolic processes; overproduction causes decreased cellular content of glycogen [Source:SGD;Acc:S000001899]
F	YFR004W	RPN11	1675	-212	4	Metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; couples the deubiquitination and degradation of proteasome substrates; involved, independent of catalytic activity, in fission of mitochondria and peroxisomes [Source:SGD;Acc:S000001900]
F	YFR005C	SAD1	213	-180.7	4	Conserved zinc-finger domain protein involved in pre-mRNA splicing, required for assembly of U4 snRNA into the U4/U6 particle [Source:SGD;Acc:S000001901]
F	YFR006W	YFR006W	1226	-468.9	4	Putative X-Pro aminopeptidase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YFR006W is not an essential gene [Source:SGD;Acc:S000001902]
F	YFR007W	YFH7	364	-340.3	4	Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases [Source:SGD;Acc:S000001903]
F	YFR008W	FAR7	84	-83.8	4	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far8p, Far9p, Far10p, and Far11p [Source:SGD;Acc:S000001904]
F	YFR009W	GCN20	1768	-752.2	4	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn1p; proposed to stimulate Gcn2p activation by an uncharged tRNA [Source:SGD;Acc:S000001905]
F	YFR009W-A	YFR009W-A	3	-1.8	1	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YFR009W; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028823]
F	YFR010W	UBP6	2048	-829.6	4	Ubiquitin-specific protease situated in the base subcomplex of the 26S proteasome, releases free ubiquitin from branched polyubiquitin chains; works in opposition to Hul5p polyubiquitin elongation activity; mutant has aneuploidy tolerance [Source:SGD;Acc:S000001906]
F	YFR010W-A	YFR010W-A	1	-4.4	2	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YFR011C; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028824]
F	YFR011C	MIC19	573	-237	4	Mitochondrial protein peripheral to the inner membrane; component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the  enance of crista junctions and inner membrane architecture [Source:SGD;Acc:S000001907]
F	YFR012W	DCV1	4	-1.6	1	Protein of unknown function; deletion mutant shows strong genetic interaction with cdc28-as1 mutant in the presence of 1-NM-PP1 [Source:SGD;Acc:S000001908]
F	YFR012W-A	YFR012W-A	0	nf	1	Putative protein of unknown function; identified by homology [Source:SGD;Acc:S000007606]
F	YFR013W	IOC3	500	-484.5	4	Member of a complex (Isw1a) with Isw1p that has nucleosome-stimulated ATPase activity and represses transcription initiation by specific positioning of a promoter proximal dinucleosome; has homology to Esc8p, which is involved in silencing [Source:SGD;Acc:S000001909]
F	YFR014C	CMK1	1047	-512.6	4	Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk2p and mammalian Cam Kinase II [Source:SGD;Acc:S000001910]
F	YFR015C	GSY1	1160	-1155.9	4	Glycogen synthase with similarity to Gsy2p, the more highly expressed yeast homolog; expression induced by glucose limitation, nitrogen starvation, environmental stress, and entry into stationary phase [Source:SGD;Acc:S000001911]
F	YFR016C	YFR016C	1228	-1104.1	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and bud; interacts with Spa2p; YFL016C is not an essential gene [Source:SGD;Acc:S000001912]
F	YFR017C	IGD1	568	-196.2	4	Cytoplasmic protein that inhibits Gdb1p glycogen debranching activity; required for normal intracellular accumulation of glycogen; phosphorylated in vivo; expression increases during wine fermentation [Source:SGD;Acc:S000001913]
F	YFR018C	YFR018C	121	-100.2	4	Putative protein of unknown function [Source:SGD;Acc:S000001914]
F	YFR019W	FAB1	501	-359.4	4	1-phosphatidylinositol-3-phosphate 5-kinase; vacuolar membrane kinase that generates phosphatidylinositol (3,5)P2, which is involved in vacuolar sorting and homeostasis [Source:SGD;Acc:S000001915]
F	YFR020W	YFR020W	12	-20.9	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001916]
F	YFR021W	ATG18	272	-157.5	4	Phosphoinositide binding protein required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein [Source:SGD;Acc:S000001917]
F	YFR022W	ROG3	111	-79.3	4	Protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; has similarity to Rod1p; mutation suppresses the temperature sensitivity of an mck1 rim11 double mutant; proposed to regulate the endocytosis of plasma membrane proteins [Source:SGD;Acc:S000001918]
F	YFR023W	PES4	34	-25.4	2	Poly(A) binding protein, suppressor of DNA polymerase epsilon mutation, similar to Mip6p [Source:SGD;Acc:S000001919]
F	YFR024C-A	LSB3	1880	-395.6	4	Protein containing a C-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization [Source:SGD;Acc:S000002968]
F	YFR025C	HIS2	316	-127.1	4	Histidinolphosphatase, catalyzes the eighth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control [Source:SGD;Acc:S000001921]
F	YFR026C	ULI1	4	-2.1	2	Putative protein of unknown function involved in and induced by the endoplasmic reticulum unfolded protein response [Source:SGD;Acc:S000001922]
F	YFR027W	ECO1	35	-12	2	Acetyltransferase required for establishment of sister chromatid cohesion; modifies Smc3p at replication forks and Mcd1p in response to ds DNA breaks; has a C2H2-type zinc finger; mutations in human homolog ESCO2 cause Roberts syndrome [Source:SGD;Acc:S000001923]
F	YFR028C	CDC14	1264	-1577.2	4	Protein phosphatase required for mitotic exit; located in the nucleolus until liberated by the FEAR and Mitotic Exit Network in anaphase, enabling it to act on key substrates to effect a decrease in CDK/B-cyclin activity and mitotic exit; required f  osis I spindle disassembly; released from nucleolus upon entry into anaphase I of meiosis, resequestered in metaphase II, then released again upon entry into anaphase II; maintained in nucleolus by Cdc55p in early meiosis [Source:SGD;Acc:S000001924]
F	YFR029W	PTR3	117	-68	4	Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes [Source:SGD;Acc:S000001925]
F	YFR030W	MET10	1077	-727.4	4	Subunit alpha of assimilatory sulfite reductase, which converts sulfite into sulfide [Source:SGD;Acc:S000001926]
F	YFR031C	SMC2	374	-375.6	4	Subunit of the condensin complex; essential SMC chromosomal ATPase family member that forms a complex with Smc4p to form the active ATPase; Smc2p/Smc4p complex binds DNA; required for clustering of tRNA genes at the nucleolus [Source:SGD;Acc:S000001927]
F	YFR031C-A	RPL2A	4418	-1495.4	4	Protein component of the large (60S) ribosomal subunit, identical to Rpl2Bp and has similarity to E. coli L2 and rat L8 ribosomal proteins [Source:SGD;Acc:S000002104]
F	YFR032C	RRT5	2	-1.1	1	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; expressed at high levels during sporulation [Source:SGD;Acc:S000001928]
F	YFR032C-A	RPL29	855	-79.6	4	Protein component of the large (60S) ribosomal subunit, has similarity to rat L29 ribosomal protein; not essential for translation, but required for proper joining of the large and small ribosomal subunits and for normal translation rate [Source:SGD;Acc:S000006437]
F	YFR032C-B	YFR032C-B	1	-1.2	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028630]
F	YFR033C	QCR6	516	-314.1	4	Subunit 6 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; highly acidic protein; required for maturation of cytochrome c1 [Source:SGD;Acc:S000001929]
F	YFR034C	PHO4	314	-95.6	4	Basic helix-loop-helix (bHLH) transcription factor of the myc-family; activates transcription cooperatively with Pho2p in response to phosphate limitation; binding to 'CACGTG' motif is regulated by chromatin restriction, competitive binding of Cbf1p  e same DNA binding motif and cooperation with Pho2p,; function is regulated by phosphorylation at multiple sites and by phosphate availability [Source:SGD;Acc:S000001930]
F	YFR034W-A	YFR034W-A	0	nf	1	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps YFR035C; identified by gene-trapping, microarray expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028631]
F	YFR035C	YFR035C	4	-1.4	1	Putative protein of unknown function, deletion mutant exhibits synthetic phenotype with alpha-synuclein [Source:SGD;Acc:S000001931]
F	YFR036W	CDC26	55	-60	4	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [Source:SGD;Acc:S000001932]
F	YFR036W-A	YFR036W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene RSC8 [Source:SGD;Acc:S000028767]
F	YFR037C	RSC8	1711	-494.9	4	Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters [Source:SGD;Acc:S000001933]
F	YFR038W	IRC5	294	-170	4	Putative ATPase containing the DEAD/H helicase-related sequence motif; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000001934]
F	YFR039C	OSW7	243	-250.1	4	Putative protein of unknown function; may be involved in response to high salt and changes in carbon source; deletion mutant has decreased spore survival in Drosophila feces [Source:SGD;Acc:S000001935]
F	YFR040W	SAP155	874	-766.8	4	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap185p, and Sap190p [Source:SGD;Acc:S000001936]
F	YFR041C	ERJ5	548	-173.5	4	Type I membrane protein with a J domain is required to preserve the folding capacity of the endoplasmic reticulum; loss of the non-essential ERJ5 gene leads to a constitutively induced unfolded protein response [Source:SGD;Acc:S000001937]
F	YFR042W	KEG1	28	-30	4	Integral membrane protein of the ER; physically interacts with Kre6p; has a role in the synthesis of beta-1,6-glucan in the cell wall; required for cell viability [Source:SGD;Acc:S000001938]
F	YFR043C	IRC6	104	-68.6	4	Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000001939]
F	YFR044C	DUG1	2703	-632.5	4	Cys-Gly metallo-di-peptidase; forms a complex with Dug2p and Dug3p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) [Source:SGD;Acc:S000001940]
F	YFR045W	YFR045W	192	-124	4	Putative mitochondrial transport protein; null mutant is viable, exhibits decreased levels of chitin and normal resistance to calcofluor white [Source:SGD;Acc:S000001941]
F	YFR046C	CNN1	47	-30.7	4	Kinetochore protein of unknown function; associated with the essential kinetochore proteins Nnf1p and Spc24p; phosphorylated by both Clb5-Cdk1 and, to a lesser extent, Clb2-Cdk1. [Source:SGD;Acc:S000001942]
F	YFR047C	BNA6	783	-348	4	Quinolinate phosphoribosyl transferase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p [Source:SGD;Acc:S000001943]
F	YFR048W	RMD8	285	-158.9	4	Cytosolic protein required for sporulation [Source:SGD;Acc:S000001944]
F	YFR049W	YMR31	814	-149.1	4	Mitochondrial ribosomal protein of the small subunit, has similarity to human mitochondrial ribosomal protein MRP-S36 [Source:SGD;Acc:S000001945]
F	YFR050C	PRE4	1101	-233.9	4	Beta 7 subunit of the 20S proteasome [Source:SGD;Acc:S000001946]
F	YFR051C	RET2	1677	-499.1	4	Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER [Source:SGD;Acc:S000001947]
F	YFR052C-A	YFR052C-A	7	-2.7	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028768]
F	YFR052W	RPN12	1660	-268.3	4	Subunit of the 19S regulatory particle of the 26S proteasome lid; synthetically lethal with RPT1, which is an ATPase component of the 19S regulatory particle; physically interacts with Nob1p and Rpn3p [Source:SGD;Acc:S000001948]
F	YFR053C	HXK1	3880	-2099.3	4	Hexokinase isoenzyme 1, a cytosolic protein that catalyzes phosphorylation of glucose during glucose metabolism; expression is highest during growth on non-glucose carbon sources; glucose-induced repression involves the hexokinase Hxk2p [Source:SGD;Acc:S000001949]
F	YFR054C	YFR054C	8	-7.3	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001950]
F	YFR055W	IRC7	26	-10.4	2	Beta-lyase involved in the production of thiols; null mutant displays increased levels of spontaneous Rad52p foci; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner and by copper levels in a Mac1-dependent manner [Source:SGD;Acc:S000001952]
F	YFR056C	YFR056C	0	nf	1	Dubious open reading frame unlikely to encode a protein based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YFR055W [Source:SGD;Acc:S000001951]
F	YFR057W	YFR057W	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000001953]
G	YGL001C	ERG26	1292	-576.6	4	C-3 sterol dehydrogenase, catalyzes the second of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis [Source:SGD;Acc:S000002969]
G	YGL002W	ERP6	83	-84.3	4	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000002970]
G	YGL003C	CDH1	116	-131.5	4	Cell-cycle regulated activator of the anaphase-promoting complex/cyclosome (APC/C), which directs ubiquitination of cyclins resulting in mitotic exit; targets the APC/C to specific substrates including Cdc20p, Ase1p, Cin8p and Fin1p [Source:SGD;Acc:S000002971]
G	YGL004C	RPN14	290	-250.5	4	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p [Source:SGD;Acc:S000002972]
G	YGL005C	COG7	426	-149.3	4	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000002973]
G	YGL006W	PMC1	870	-718.2	4	Vacuolar Ca2+ ATPase involved in depleting cytosol of Ca2+ ions; prevents growth inhibition by activation of calcineurin in the presence of elevated concentrations of calcium; similar to mammalian PMCA1a [Source:SGD;Acc:S000002974]
G	YGL006W-A	YGL006W-A	0	nf	1	Putative protein of unknown function; identified by SAGE [Source:SGD;Acc:S000028769]
G	YGL007C-A	YGL007C-A	1	-1.5	1	Putative protein of unknown function, identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; deletion exhibits slow-growth phenotype; computationally predicted to have a role in cell budding [Source:SGD;Acc:S000028632]
G	YGL007W	BRP1	13	-3.3	2	Dubious ORF located in the upstream region of PMA1, deletion leads to polyamine resistance due to downregulation of PMA1 [Source:SGD;Acc:S000002975]
G	YGL008C	PMA1	5315	-2209.7	4	Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+] [Source:SGD;Acc:S000002976]
G	YGL009C	LEU1	3755	-2161.2	4	Isopropylmalate isomerase, catalyzes the second step in the leucine biosynthesis pathway [Source:SGD;Acc:S000002977]
G	YGL010W	MPO1	57	-24.2	3	Putative protein of unknown function; YGL010W is not an essential gene [Source:SGD;Acc:S000002978]
G	YGL011C	SCL1	2181	-378.3	4	Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria [Source:SGD;Acc:S000002979]
G	YGL012W	ERG4	800	-156.9	4	C-24(28) sterol reductase, catalyzes the final step in ergosterol biosynthesis; mutants are viable, but lack ergosterol [Source:SGD;Acc:S000002980]
G	YGL013C	PDR1	538	-320.4	4	Zinc cluster protein that is a master regulator involved in recruiting other zinc cluster proteins to pleiotropic drug response elements (PDREs) to fine tune the regulation of multidrug resistance genes [Source:SGD;Acc:S000002981]
G	YGL014C-A	YGL014C-A	0	nf	1	Dubious open reading frame, unlikely to encode a functional protein; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028825]
G	YGL014W	PUF4	1129	-271.8	4	Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding nucleolar ribosomal RNA-processing factors [Source:SGD;Acc:S000002982]
G	YGL015C	YGL015C	2	-2.5	2	Putative protein of unknown function; null mutants accumulate cargo in the Golgi [Source:SGD;Acc:S000002983]
G	YGL016W	KAP122	852	-451	4	Karyopherin beta, responsible for import of the Toa1p-Toa2p complex into the nucleus; binds to nucleoporins Nup1p and Nup2p; may play a role in regulation of pleiotropic drug resistance [Source:SGD;Acc:S000002984]
G	YGL017W	ATE1	261	-254.3	4	Arginyl-tRNA-protein transferase, catalyzes post-translational conjugation of arginine to the amino termini of acceptor proteins which are then subject to degradation via the N-end rule pathway [Source:SGD;Acc:S000002985]
G	YGL018C	JAC1	294	-103.2	4	Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix [Source:SGD;Acc:S000002986]
G	YGL019W	CKB1	1130	-451	4	Beta regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases [Source:SGD;Acc:S000002987]
G	YGL020C	GET1	798	-200.7	4	Subunit of the GET complex; involved in insertion of proteins into the ER membrane; required for the retrieval of HDEL proteins from the Golgi to the ER in an ERD2 dependent fashion and for normal mitochondrial morphology and inheritance [Source:SGD;Acc:S000002988]
G	YGL021W	ALK1	302	-87.4	4	Protein kinase; accumulation and phosphorylation are periodic during the cell cycle; phosphorylated in response to DNA damage; contains characteristic motifs for degradation via the APC pathway; similar to Alk2p and to mammalian haspins [Source:SGD;Acc:S000002989]
G	YGL022W	STT3	1239	-289.7	4	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; forms a subcomplex with Ost3p and Ost4p and is directly involved in catalysis [Source:SGD;Acc:S000002990]
G	YGL023C	PIB2	757	-287.7	4	Protein binding phosphatidylinositol 3-phosphate, involved in telomere-proximal repression of gene expression; similar to Fab1 and Vps27 [Source:SGD;Acc:S000002991]
G	YGL024W	YGL024W	6	-12	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF PGD1/YGL025C [Source:SGD;Acc:S000002992]
G	YGL025C	PGD1	413	-126.5	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for basal and activated transcription; direct target of Cyc8p-Tup1p transcriptional corepressor [Source:SGD;Acc:S000002993]
G	YGL026C	TRP5	3470	-1392.6	4	Tryptophan synthase, catalyzes the last step of tryptophan biosynthesis; regulated by the general control system of amino acid biosynthesis [Source:SGD;Acc:S000002994]
G	YGL027C	CWH41	1168	-598.1	4	Processing alpha glucosidase I, ER type II integral membrane N-glycoprotein involved in assembly of cell wall beta 1,6 glucan and asparagine-linked protein glycosylation; also involved in ER protein quality control and sensing of ER stress [Source:SGD;Acc:S000002995]
G	YGL028C	SCW11	279	-201.5	4	Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on its regulation by Ste12p [Source:SGD;Acc:S000002996]
G	YGL029W	CGR1	52	-45.8	2	Protein involved in nucleolar integrity and processing of the pre-rRNA for the 60S ribosome subunit; transcript is induced in response to cytotoxic stress but not genotoxic stress [Source:SGD;Acc:S000002997]
G	YGL030W	RPL30	4048	-385.4	4	Protein component of the large (60S) ribosomal subunit, has similarity to rat L30 ribosomal protein; involved in pre-rRNA processing in the nucleolus; autoregulates splicing of its transcript [Source:SGD;Acc:S000002998]
G	YGL031C	RPL24A	3603	-332.3	4	Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Bp and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate [Source:SGD;Acc:S000002999]
G	YGL032C	AGA2	28	-8.6	4	Adhesion subunit of a-agglutinin of a-cells, C-terminal sequence acts as a ligand for alpha-agglutinin (Sag1p) during agglutination, modified with O-linked oligomannosyl chains, linked to anchorage subunit Aga1p via two disulfide bonds [Source:SGD;Acc:S000003000]
G	YGL033W	HOP2	3	-11.8	2	Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair [Source:SGD;Acc:S000003001]
G	YGL034C	YGL034C	6	-2.4	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003002]
G	YGL035C	MIG1	685	-270.1	4	Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase [Source:SGD;Acc:S000003003]
G	YGL036W	YGL036W	267	-288.2	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YGL036W is not an essential gene [Source:SGD;Acc:S000003004]
G	YGL037C	PNC1	2467	-396.9	4	Nicotinamidase that converts nicotinamide to nicotinic acid as part of the NAD(+) salvage pathway, required for life span extension by calorie restriction; PNC1 expression responds to all known stimuli that extend replicative life span [Source:SGD;Acc:S000003005]
G	YGL038C	OCH1	533	-285	4	Mannosyltransferase of the cis-Golgi apparatus, initiates the polymannose outer chain elongation of N-linked oligosaccharides of glycoproteins [Source:SGD;Acc:S000003006]
G	YGL039W	YGL039W	907	-230.6	4	Oxidoreductase shown to reduce carbonyl compounds to chiral alcohols [Source:SGD;Acc:S000003007]
G	YGL040C	HEM2	1330	-658	4	Aminolevulinate dehydratase, a homo-octameric enzyme, catalyzes the conversion of 5-aminolevulinate to porphobilinogen, the second step in heme biosynthesis; enzymatic activity is zinc-dependent; localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000003008]
G	YGL041C	YGL041C	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003009]
G	YGL041C-B	YGL041C-B	1	-1.2	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028548]
G	YGL041W-A	YGL041W-A	282	-74.2	4	Putative protein of unknown function, conserved in fungi; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028826]
G	YGL042C	YGL042C	0	nf	1	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation blocks replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene DST1 [Source:SGD;Acc:S000003010]
G	YGL043W	DST1	1510	-301.9	4	General transcription elongation factor TFIIS, enables RNA polymerase II to read through blocks to elongation by stimulating cleavage of nascent transcripts stalled at transcription arrest sites [Source:SGD;Acc:S000003011]
G	YGL044C	RNA15	421	-86.2	4	Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; interacts with the A-rich polyadenylation signa  omplex with Rna14p and Hrp1p; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping [Source:SGD;Acc:S000003012]
G	YGL045W	RIM8	202	-189.5	4	Protein involved in proteolytic activation of Rim101p in response to alkaline pH; interacts with ESCRT-1 subunits Stp22p and Vps28p; essential for anaerobic growth; member of the arrestin-related trafficking adaptor family [Source:SGD;Acc:S000003013]
G	YGL047W	ALG13	250	-141.8	4	Catalytic component of UDP-GlcNAc transferase, required for the second step of dolichyl-linked oligosaccharide synthesis; anchored to the ER membrane via interaction with Alg14p; similar to bacterial and human glycosyltransferases [Source:SGD;Acc:S000003015]
G	YGL048C	RPT6	2417	-414	4	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; bound by ubiquitin-protein ligases Ubr1p and Ufd4p; localized mainly to the nucleus throughout the cell cycle [Source:SGD;Acc:S000003016]
G	YGL049C	TIF4632	2240	-552.9	4	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); associates with the poly(A)-binding protein Pab1p, also interacts with eIF4A (Tif1p); homologous to Tif4631p [Source:SGD;Acc:S000003017]
G	YGL050W	TYW3	430	-130.2	4	tRNA methyltransferase required for synthesis of wybutosine, a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticodon interactions [Source:SGD;Acc:S000003018]
G	YGL051W	MST27	130	-100.5	4	Putative integral membrane protein, involved in vesicle formation; forms complex with Mst28p; member of DUP240 gene family; binds COPI and COPII vesicles [Source:SGD;Acc:S000003019]
G	YGL052W	YGL052W	4	-10.8	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MST27 [Source:SGD;Acc:S000003020]
G	YGL053W	PRM8	125	-115	4	Pheromone-regulated protein with 2 predicted transmembrane segments and an FF sequence, a motif involved in COPII binding; forms a complex with Prp9p in the ER; member of DUP240 gene family [Source:SGD;Acc:S000003021]
G	YGL054C	ERV14	666	-47.3	4	Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo; required for the delivery of bud-site selection protein Axl2p to cell surface; related to Drosophila cornichon [Source:SGD;Acc:S000003022]
G	YGL055W	OLE1	1836	-480.2	4	Delta(9) fatty acid desaturase, required for monounsaturated fatty acid synthesis and for normal distribution of mitochondria [Source:SGD;Acc:S000003023]
G	YGL056C	SDS23	1138	-475.2	4	One of two S. cerevisiae homologs (Sds23p and Sds24p) of the S. pombe Sds23 protein, which is implicated in APC/cyclosome regulation; involved in cell separation during budding [Source:SGD;Acc:S000003024]
G	YGL057C	GEP7	197	-138.9	4	Protein of unknown function; null mutant exhibits a respiratory growth defect and synthetic interactions with prohibitin (phb1) and gem1; authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003025]
G	YGL058W	RAD6	214	-93.6	4	Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p [Source:SGD;Acc:S000003026]
G	YGL059W	PKP2	114	-397.8	4	Mitochondrial protein kinase that negatively regulates activity of the pyruvate dehydrogenase complex by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp1p and phosphatases Ptc5p and Ptc6p [Source:SGD;Acc:S000003027]
G	YGL060W	YBP2	139	-280.4	4	Central kinetochore associated protein that mediates mitotic progression; interacts with several central kinetochore proteins and the centromeric histone Cse4p; role in resistance to oxidative stress; similarity to Ybp1p and Slk19p [Source:SGD;Acc:S000003028]
G	YGL061C	DUO1	315	-113.1	4	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis [Source:SGD;Acc:S000003029]
G	YGL062W	PYC1	3387	-1853.7	4	Pyruvate carboxylase isoform, cytoplasmic enzyme that converts pyruvate to oxaloacetate; highly similar to isoform Pyc2p but differentially regulated; mutations in the human homolog are associated with lactic acidosis [Source:SGD;Acc:S000003030]
G	YGL063C-A	YGL063C-A	2	-1.8	1	Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028633]
G	YGL063W	PUS2	61	-66.4	4	Mitochondrial tRNA:pseudouridine synthase; acts at positions 27 and 28, but not at position 72; efficiently and rapidly targeted to mitochondria, specifically dedicated to mitochondrial tRNA modification [Source:SGD;Acc:S000003031]
G	YGL064C	MRH4	366	-345.7	4	Mitochondrial ATP-dependent RNA helicase of the DEAD-box family, plays an essential role in mitochondrial function [Source:SGD;Acc:S000003032]
G	YGL065C	ALG2	683	-269.9	4	Mannosyltransferase that catalyzes two consecutive steps in the N-linked glycosylation pathway; alg2 mutants exhibit temperature-sensitive growth and abnormal accumulation of the lipid-linked oligosaccharide Man2GlcNAc2-PP-Dol [Source:SGD;Acc:S000003033]
G	YGL066W	SGF73	741	-870.7	4	SAGA complex subunit; has a role in anchoring the deubiquitination module into SAGA and SLIK complexes; involved in preinitiation complex assembly at promoters; human ortholog ataxin-7 is associated with spinocerebellar ataxia diseases; mutant displ  duced transcription elongation in the G-less-based run-on (GLRO) assay [Source:SGD;Acc:S000003034]
G	YGL067W	NPY1	635	-140.1	4	NADH diphosphatase (pyrophosphatase), hydrolyzes the pyrophosphate linkage in NADH and related nucleotides; localizes to peroxisomes [Source:SGD;Acc:S000003035]
G	YGL068W	MNP1	1502	-178.3	4	Protein associated with the mitochondrial nucleoid; putative mitochondrial ribosomal protein with similarity to E. coli L7/L12 ribosomal protein; required for normal respiratory growth [Source:SGD;Acc:S000003036]
G	YGL069C	YGL069C	7	-47.2	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 92% of ORF overlaps the uncharacterized ORF YGL068W; deletion in cyr1 mutant results in loss of stress resistance [Source:SGD;Acc:S000003037]
G	YGL070C	RPB9	472	-160.3	4	RNA polymerase II subunit B12.6; contacts DNA; mutations affect transcription start site selection and fidelity of transcription [Source:SGD;Acc:S000003038]
G	YGL071W	AFT1	139	-132.7	4	Transcription factor involved in iron utilization and homeostasis; binds the consensus site PyPuCACCCPu and activates the expression of target genes in response to changes in iron availability [Source:SGD;Acc:S000003039]
G	YGL072C	YGL072C	3	-1.4	1	Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HSF1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 [Source:SGD;Acc:S000003040]
G	YGL073W	HSF1	682	-424.1	4	Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated [Source:SGD;Acc:S000003041]
G	YGL074C	YGL074C	2	-2.5	2	Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential HSF1 gene encoding heat shock transcription factor [Source:SGD;Acc:S000003042]
G	YGL075C	MPS2	103	-128.3	4	Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000003043]
G	YGL076C	RPL7A	4831	-784.8	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Bp and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2) [Source:SGD;Acc:S000003044]
G	YGL077C	HNM1	412	-99.7	4	Choline/ethanolamine transporter; involved in the uptake of nitrogen mustard and the uptake of glycine betaine during hypersaline stress; co-regulated with phospholipid biosynthetic genes and negatively regulated by choline and myo-inositol [Source:SGD;Acc:S000003045]
G	YGL078C	DBP3	2190	-444.3	4	Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis [Source:SGD;Acc:S000003046]
G	YGL079W	KXD1	75	-53.2	4	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome [Source:SGD;Acc:S000003047]
G	YGL080W	MPC1	178	-115.6	4	Putative protein of unknown function; highly conserved across species and orthologous to human gene BRP44L; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003048]
G	YGL081W	YGL081W	12	-24.3	2	Putative protein of unknown function; non-essential gene; interacts genetically with CHS5, a gene involved in chitin biosynthesis [Source:SGD;Acc:S000003049]
G	YGL082W	YGL082W	950	-376.3	4	Putative protein of unknown function; predicted prenylation/proteolysis target of Afc1p and Rce1p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YGL082W is not an essential gene [Source:SGD;Acc:S000003050]
G	YGL083W	SCY1	585	-1158.3	4	Putative kinase, suppressor of GTPase mutant, similar to bovine rhodopsin kinase [Source:SGD;Acc:S000003051]
G	YGL084C	GUP1	627	-183	4	Plasma membrane protein involved in remodeling GPI anchors; member of the MBOAT family of putative membrane-bound O-acyltransferases; proposed to be involved in glycerol transport [Source:SGD;Acc:S000003052]
G	YGL085W	LCL3	17	-48.5	4	Putative protein of unknown function; mutant has long chronological lifespan; has homology to Staphylococcus aureus nuclease; GFP-fusion protein localizes to mitochondria; is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000003053]
G	YGL086W	MAD1	607	-431.5	4	Coiled-coil protein involved in the spindle-assembly checkpoint; phosphorylated by Mps1p upon checkpoint activation which leads to inhibition of the activity of the anaphase promoting complex; forms a complex with Mad2p [Source:SGD;Acc:S000003054]
G	YGL087C	MMS2	827	-157.5	4	Ubiquitin-conjugating enzyme variant involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p [Source:SGD;Acc:S000003055]
G	YGL088W	YGL088W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps snR10, a snoRNA required for preRNA processing [Source:SGD;Acc:S000003056]
G	YGL089C	MF(ALPHA)2	11	-16.2	4	MF(ALPHA)2, Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2 [Source:SGD;Acc:S000003057]
G	YGL090W	LIF1	70	-164.2	4	Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein [Source:SGD;Acc:S000003058]
G	YGL091C	NBP35	236	-95.8	4	Essential iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Cfd1p that is involved in iron-sulfur protein assembly in the cytosol; similar to P-loop NTPases [Source:SGD;Acc:S000003059]
G	YGL092W	NUP145	1823	-1634.8	4	Essential nucleoporin, subunit of the Nup84p subcomplex; catalyzes its own cleavage in vivo to generate a C-terminal fragment that assembles into the Nup84p subcomplex of the nuclear pore complex, and an N-terminal fragment of unknown function that   ologous to Nup100p; the Nup84 subcomplex has a role in transcription elongation [Source:SGD;Acc:S000003060]
G	YGL093W	SPC105	262	-238.3	4	Subunit of a kinetochore-microtubule binding complex with Kre28p that bridges centromeric heterochromatin and kinetochore MAPs and motors; required for sister chromatid bi-orientation and kinetochore binding of SAC components [Source:SGD;Acc:S000003061]
G	YGL094C	PAN2	394	-339.9	4	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes [Source:SGD;Acc:S000003062]
G	YGL095C	VPS45	609	-305.6	4	Protein of the Sec1p/Munc-18 family, essential for vacuolar protein sorting; required for the function of Pep12p and the early endosome/late Golgi SNARE Tlg2p; essential for fusion of Golgi-derived vesicles with the prevacuolar compartment [Source:SGD;Acc:S000003063]
G	YGL096W	TOS8	13	-30.8	2	Homeodomain-containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; induced during meiosis and under cell-damaging conditions; similar to Cup9p transcription factor [Source:SGD;Acc:S000003064]
G	YGL097W	SRM1	1859	-333.3	4	Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000003065]
G	YGL098W	USE1	227	-150.2	4	Essential SNARE protein localized to the ER, involved in retrograde traffic from the Golgi to the ER; forms a complex with the SNAREs Sec22p, Sec20p and Ufe1p [Source:SGD;Acc:S000003066]
G	YGL099W	LSG1	1645	-513.7	4	Putative GTPase involved in 60S ribosomal subunit biogenesis; required for the release of Nmd3p from 60S subunits in the cytoplasm [Source:SGD;Acc:S000003067]
G	YGL100W	SEH1	1140	-486.9	4	Nuclear pore protein of the conserved Nup84p complex (Nup84p, Nup85p, Nup120p, Nup145p, and Seh1p); part of the SEA (Seh1-associated) complex, a coatamer-related complex that associates dynamically with the vacuole; homologous to Sec13p; the Nup84 s  lex has a role in transcription elongation [Source:SGD;Acc:S000003068]
G	YGL101W	YGL101W	440	-153.3	4	Putative protein of unknown function; non-essential gene with similarity to YBR242W; interacts with the DNA helicase Hpr5p [Source:SGD;Acc:S000003069]
G	YGL102C	YGL102C	0	nf	1	Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential RPL28 gene encoding a large subunit ribosomal protein [Source:SGD;Acc:S000003070]
G	YGL103W	RPL28	4072	-486.8	4	Ribosomal protein of the large (60S) ribosomal subunit, has similarity to E. coli L15 and rat L27a ribosomal proteins; may have peptidyl transferase activity; can mutate to cycloheximide resistance [Source:SGD;Acc:S000003071]
G	YGL104C	VPS73	75	-53.1	4	Mitochondrial protein; mutation affects vacuolar protein sorting; putative transporter; member of the sugar porter family [Source:SGD;Acc:S000003072]
G	YGL105W	ARC1	2832	-739.1	4	Protein that binds tRNA and methionyl- and glutamyl-tRNA synthetases (Mes1p and Gus1p), delivering tRNA to them, stimulating catalysis, and ensuring their localization to the cytoplasm; also binds quadruplex nucleic acids [Source:SGD;Acc:S000003073]
G	YGL106W	MLC1	1917	-394.1	4	Essential light chain for Myo1p, light chain for Myo2p; stabilizes Myo2p by binding to the neck region; interacts with Myo1p, Iqg1p, and Myo2p to coordinate formation and contraction of the actomyosin ring with targeted membrane deposition [Source:SGD;Acc:S000003074]
G	YGL107C	RMD9	604	-484.9	4	Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes [Source:SGD;Acc:S000003075]
G	YGL108C	YGL108C	103	-42.8	4	Protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000003076]
G	YGL109W	YGL109W	2	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized gene YGL108C [Source:SGD;Acc:S000003077]
G	YGL110C	CUE3	329	-200.6	4	Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination [Source:SGD;Acc:S000003078]
G	YGL111W	NSA1	981	-329.4	4	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis [Source:SGD;Acc:S000003079]
G	YGL112C	TAF6	1053	-1806.2	4	Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4 [Source:SGD;Acc:S000003080]
G	YGL113W	SLD3	66	-64.5	4	Protein involved in the initiation of DNA replication, required for proper assembly of replication proteins at the origins of replication; interacts with Cdc45p [Source:SGD;Acc:S000003081]
G	YGL114W	YGL114W	183	-113.1	4	Putative protein of unknown function; predicted member of the oligopeptide transporter (OPT) family of membrane transporters [Source:SGD;Acc:S000003082]
G	YGL115W	SNF4	1216	-431	4	Activating gamma subunit of the AMP-activated Snf1p kinase complex (contains Snf1p and a Sip1p/Sip2p/Gal83p family member); activates glucose-repressed genes, represses glucose-induced genes; role in sporulation, and peroxisome biogenesis [Source:SGD;Acc:S000003083]
G	YGL116W	CDC20	80	-16.8	3	Cell-cycle regulated activator of anaphase-promoting complex/cyclosome (APC/C), which is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; potential Cdc28p substrate [Source:SGD;Acc:S000003084]
G	YGL117W	YGL117W	168	-175.8	4	Putative protein of unknown function [Source:SGD;Acc:S000003085]
G	YGL118C	YGL118C	4	-2.4	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003086]
G	YGL119W	COQ8	343	-1257.3	4	Protein required for ubiquinone (coenzyme Q) biosynthesis and for respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis [Source:SGD;Acc:S000003087]
G	YGL120C	PRP43	2332	-543.6	4	RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome [Source:SGD;Acc:S000003088]
G	YGL121C	GPG1	246	-44	4	Proposed gamma subunit of the heterotrimeric G protein that interacts with the receptor Gpr1p; involved in regulation of pseudohyphal growth; requires Gpb1p or Gpb2p to interact with Gpa2p; overproduction causes prion curing [Source:SGD;Acc:S000003089]
G	YGL122C	NAB2	1020	-357	4	Nuclear polyadenylated RNA-binding protein required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p [Source:SGD;Acc:S000003090]
G	YGL123C-A	YGL123C-A	1	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPS2/YGL123W [Source:SGD;Acc:S000028634]
G	YGL123W	RPS2	4552	-1087.6	4	Protein component of the small (40S) subunit, essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p [Source:SGD;Acc:S000003091]
G	YGL124C	MON1	168	-139.5	4	Protein required for fusion of cvt-vesicles and autophagosomes with the vacuole; associates, as a complex with Ccz1p, with a perivacuolar compartment; potential Cdc28p substrate [Source:SGD;Acc:S000003092]
G	YGL125W	MET13	921	-478.8	4	Major isozyme of methylenetetrahydrofolate reductase, catalyzes the reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate in the methionine biosynthesis pathway [Source:SGD;Acc:S000003093]
G	YGL126W	SCS3	165	-101	4	Protein required for inositol prototrophy, identified as an ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis; disputed role in the synthesis of inositol phospholipids from inositol [Source:SGD;Acc:S000003094]
G	YGL127C	SOH1	74	-34.9	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; involved in telomere maintenance; conserved with other metazoan MED31 subunits [Source:SGD;Acc:S000003095]
G	YGL128C	CWC23	84	-46.5	4	Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to E. coli DnaJ and other DnaJ-like proteins and to S. pombe Cwf23p [Source:SGD;Acc:S000003096]
G	YGL129C	RSM23	583	-327.4	4	Mitochondrial ribosomal protein of the small subunit, has similarity to mammalian apoptosis mediator proteins; null mutation prevents induction of apoptosis by overproduction of metacaspase Mca1p [Source:SGD;Acc:S000003097]
G	YGL130W	CEG1	619	-355.3	4	Alpha (guanylyltransferase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CET1, an RNA 5'-triphosphatase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide [Source:SGD;Acc:S000003098]
G	YGL131C	SNT2	72	-47.1	3	DNA binding protein with similarity to the S. pombe Snt2 protein; computational analysis suggests a role in regulation of expression of genes encoding amine transporters [Source:SGD;Acc:S000003099]
G	YGL132W	YGL132W	2	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SNT2/YGL131C [Source:SGD;Acc:S000003100]
G	YGL133W	ITC1	488	-511	4	Subunit of the ATP-dependent Isw2p-Itc1p chromatin remodeling complex, required for repression of a-specific genes, repression of early meiotic genes during mitotic growth, and repression of INO1; similar to mammalian Acf1p, the regulatory subunit o  mammalian ATP-utilizing chromatin assembly and modifying factor (ACF) complex [Source:SGD;Acc:S000003101]
G	YGL134W	PCL10	65	-788	4	Pho85p cyclin; recruits, activates, and targets Pho85p cyclin-dependent protein kinase to its substrate [Source:SGD;Acc:S000003102]
G	YGL135W	RPL1B	4240	-655.3	4	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Ap and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal [Source:SGD;Acc:S000003103]
G	YGL136C	MRM2	50	-84.1	4	Mitochondrial 2' O-ribose methyltransferase, required for methylation of U(2791) in 21S rRNA; MRM2 deletion confers thermosensitive respiration and loss of mitochondrial DNA; has similarity to Spb1p and Trm7p, and to E. coli FtsJ/RrmJ [Source:SGD;Acc:S000003104]
G	YGL137W	SEC27	3012	-1114.6	4	Essential beta'-coat protein of the COPI coatomer, involved in ER-to-Golgi and Golgi-to-ER transport; contains WD40 domains that mediate cargo selective interactions; 45% sequence identity to mammalian beta'-COP [Source:SGD;Acc:S000003105]
G	YGL138C	YGL138C	3	-10.9	2	Putative protein of unknown function; has no significant sequence similarity to any known protein [Source:SGD;Acc:S000003106]
G	YGL139W	FLC3	714	-140.3	4	Putative FAD transporter, similar to Flc1p and Flc2p; localized to the ER [Source:SGD;Acc:S000003107]
G	YGL140C	YGL140C	511	-258.1	4	Putative protein of unknown function; non-essential gene; contains multiple predicted transmembrane domains [Source:SGD;Acc:S000003108]
G	YGL141W	HUL5	340	-369.9	4	Multiubiquitin chain assembly factor (E4); proteasome processivity factor that elongates polyUb chains on substrates, opposing Ubp6p, a branched polyubiquitin protease; required for retrograde transport of misfolded proteins during ERAD [Source:SGD;Acc:S000003109]
G	YGL142C	GPI10	58	-128.1	4	Integral membrane protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; putative alpha 1,2 mannosyltransferase required for addition of the third mannose onto the GPI core structure; human PIG-Bp is a functional homolog [Source:SGD;Acc:S000003110]
G	YGL143C	MRF1	168	-137.1	4	Mitochondrial translation release factor, involved in stop codon recognition and hydrolysis of the peptidyl-tRNA bond during mitochondrial translation; lack of MRF1 causes mitochondrial genome instability [Source:SGD;Acc:S000003111]
G	YGL144C	ROG1	82	-66.9	4	Protein with putative serine active lipase domain [Source:SGD;Acc:S000003112]
G	YGL145W	TIP20	476	-447.6	4	Peripheral membrane protein required for fusion of COPI vesicles with the ER; prohibits back-fusion of COPII vesicles with the ER; forms a tethering complex with Sec39p and Dsl1p that interacts with ER SNAREs Sec20p and Use1p [Source:SGD;Acc:S000003113]
G	YGL146C	RRT6	14	-43.5	3	Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins [Source:SGD;Acc:S000003114]
G	YGL147C	RPL9A	4322	-695	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Bp and has similarity to E. coli L6 and rat L9 ribosomal proteins [Source:SGD;Acc:S000003115]
G	YGL148W	ARO2	2694	-509.5	4	Bifunctional chorismate synthase and flavin reductase, catalyzes the conversion of 5-enolpyruvylshikimate 3-phosphate (EPSP) to form chorismate, which is a precursor to aromatic amino acids [Source:SGD;Acc:S000003116]
G	YGL149W	YGL149W	2	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF INO80/YGL150C. [Source:SGD;Acc:S000003117]
G	YGL150C	INO80	955	-3842.8	4	ATPase and nucleosome spacing factor, subunit of complex containing actin and actin-related proteins that has chromatin remodeling activity and 3' to 5' DNA helicase activity in vitro; has a role in modulating stress gene transcription [Source:SGD;Acc:S000003118]
G	YGL151W	NUT1	779	-507.3	4	Component of the RNA polymerase II mediator complex, which is required for transcriptional activation and also has a role in basal transcription [Source:SGD;Acc:S000003119]
G	YGL152C	YGL152C	10	-19.6	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF PEX14/YGL153W [Source:SGD;Acc:S000003120]
G	YGL153W	PEX14	921	-1592.3	4	Peroxisomal membrane peroxin that is a central component of the peroxisomal protein import machinery; interacts with both PTS1 (Pex5p) and PTS2 (Pex7p), peroxisomal matrix protein signal recognition factors and membrane receptor Pex13p [Source:SGD;Acc:S000003121]
G	YGL154C	LYS5	11	-16.8	3	Phosphopantetheinyl transferase involved in lysine biosynthesis; converts inactive apo-form of Lys2p (alpha-aminoadipate reductase) into catalytically active holo-form by posttranslational addition of phosphopantetheine [Source:SGD;Acc:S000003122]
G	YGL155W	CDC43	132	-158.9	4	Beta subunit of geranylgeranyltransferase type I, catalyzes geranylgeranylation to the cysteine residue in proteins containing a C-terminal CaaX sequence ending in Leu or Phe; has substrates important for morphogenesis [Source:SGD;Acc:S000003123]
G	YGL156W	AMS1	943	-681.3	4	Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway [Source:SGD;Acc:S000003124]
G	YGL157W	ARI1	1534	-311.7	4	NADPH-dependent aldehyde reductase, utilizes aromatic and alophatic aldehyde substrates; member of the short-chain dehydrogenase/reductase superfamily [Source:SGD;Acc:S000003125]
G	YGL158W	RCK1	30	-892.7	4	Protein kinase involved in the response to oxidative stress; identified as suppressor of S. pombe cell cycle checkpoint mutations [Source:SGD;Acc:S000003126]
G	YGL159W	YGL159W	314	-201.2	4	Putative protein of unknown function; deletion mutant has no detectable phenotype [Source:SGD;Acc:S000003127]
G	YGL160W	AIM14	185	-113.8	4	Protein with similarity to iron/copper reductases (FRE1-8), possibly involved in iron homeostasis; may interact with ribosomes; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000003128]
G	YGL161C	YIP5	441	-96.7	4	Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport [Source:SGD;Acc:S000003129]
G	YGL162W	SUT1	38	-33.7	4	Transcription factor of the Zn[II]2Cys6 family involved in sterol uptake; involved in induction of hypoxic gene expression [Source:SGD;Acc:S000003130]
G	YGL163C	RAD54	74	-62.9	4	DNA-dependent ATPase, stimulates strand exchange by modifying the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family [Source:SGD;Acc:S000003131]
G	YGL164C	YRB30	313	-207.4	4	RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes [Source:SGD;Acc:S000003132]
G	YGL165C	YGL165C	3	-2.6	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W [Source:SGD;Acc:S000003133]
G	YGL166W	CUP2	71	-56.7	4	Copper-binding transcription factor; activates transcription of the metallothionein genes CUP1-1 and CUP1-2 in response to elevated copper concentrations [Source:SGD;Acc:S000003134]
G	YGL167C	PMR1	1368	-734.7	4	High affinity Ca2+/Mn2+ P-type ATPase required for Ca2+ and Mn2+ transport into Golgi; involved in Ca2+ dependent protein sorting and processing; mutations in human homolog ATP2C1 cause acantholytic skin condition Hailey-Hailey disease [Source:SGD;Acc:S000003135]
G	YGL168W	HUR1	0	nf	1	Protein of unknown function; reported null mutant phenotype of hydroxyurea sensitivity may be due to effects on overlapping PMR1 gene [Source:SGD;Acc:S000003136]
G	YGL169W	SUA5	380	-181	4	Single-stranded telomeric DNA-binding protein, required for normal telomere length; null mutant lacks N6-threonylcarbamoyl adenosine (t6A) modification in the anticodon loop of ANN-decoding tRNA; member of conserved YrdC/Sua5 family [Source:SGD;Acc:S000003137]
G	YGL170C	SPO74	13	-3.1	2	Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation [Source:SGD;Acc:S000003138]
G	YGL171W	ROK1	1065	-302.7	4	ATP-dependent RNA helicase of the DEAD box family; required for 18S rRNA synthesis [Source:SGD;Acc:S000003139]
G	YGL172W	NUP49	603	-411.5	4	Subunit of the Nsp1p-Nup57p-Nup49p-Nic96p subcomplex of the nuclear pore complex (NPC), required for nuclear export of ribosomes [Source:SGD;Acc:S000003140]
G	YGL173C	XRN1	3030	-1644.7	4	Evolutionarily-conserved 5'-3' exonuclease component of cytoplasmic processing (P) bodies involved in mRNA decay; plays a role in microtubule-mediated processes, filamentous growth, ribosomal RNA maturation, and telomere maintenance [Source:SGD;Acc:S000003141]
G	YGL174W	BUD13	234	-194.1	4	Subunit of the RES complex, which is required for nuclear pre-mRNA retention and splicing; involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern [Source:SGD;Acc:S000003142]
G	YGL175C	SAE2	40	-63.8	4	Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents [Source:SGD;Acc:S000003143]
G	YGL176C	YGL176C	30	-19.1	3	Putative protein of unknown function; deletion mutant is viable and has no detectable phenotype [Source:SGD;Acc:S000003144]
G	YGL177W	YGL177W	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003145]
G	YGL178W	MPT5	470	-192	4	Member of the Puf family of RNA-binding proteins; binds to mRNAs encoding chromatin modifiers and spindle pole body components; involved in longevity, maintenance of cell wall integrity, and sensitivity to and recovery from pheromone arrest [Source:SGD;Acc:S000003146]
G	YGL179C	TOS3	27	-1577.8	4	Protein kinase, related to and functionally redundant with Elm1p and Sak1p for the phosphorylation and activation of Snf1p; functionally orthologous to LKB1, a mammalian kinase associated with Peutz-Jeghers cancer-susceptibility syndrome [Source:SGD;Acc:S000003147]
G	YGL180W	ATG1	442	-1585.7	4	Protein ser/thr kinase required for vesicle formation in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; structurally required for phagophore assembly site formation; during autophagy forms a complex with Atg13p and Atg17p [Source:SGD;Acc:S000003148]
G	YGL181W	GTS1	704	-159.5	4	Protein involved in Arf3p regulation and in transcription regulation; localizes to the nucleus and to endocytic patches; contains an N-terminal Zn-finger and ArfGAP homology domain, a C-terminal glutamine-rich region, and a UBA (ubiquitin associated  in; gts1 mutations affect budding, cell size, heat tolerance, sporulation, life span, ultradian rhythms, endocytosis; expression oscillates in a pattern similar to metabolic oscillations [Source:SGD;Acc:S000003149]
G	YGL182C	YGL182C	5	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MND1/YGL183C [Source:SGD;Acc:S000003150]
G	YGL183C	MND1	7	-11.2	2	Protein required for recombination and meiotic nuclear division; forms a complex with Hop2p, which is involved in chromosome pairing and repair of meiotic double-strand breaks [Source:SGD;Acc:S000003151]
G	YGL184C	STR3	365	-166.1	4	Peroxisomal cystathionine beta-lyase, converts cystathionine into homocysteine; may be redox regulated by Gto1p [Source:SGD;Acc:S000003152]
G	YGL185C	YGL185C	282	-245.9	4	Putative protein with sequence similarity to hydroxyacid dehydrogenases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003153]
G	YGL186C	TPN1	105	-39.6	4	Plasma membrane pyridoxine (vitamin B6) transporter; member of the purine-cytosine permease subfamily within the major facilitator superfamily; proton symporter with similarity to Fcy21p, Fcy2p, and Fcy22p [Source:SGD;Acc:S000003154]
G	YGL187C	COX4	1502	-307	4	Subunit IV of cytochrome c oxidase, the terminal member of the mitochondrial inner membrane electron transport chain; precursor N-terminal 25 residues are cleaved during mitochondrial import; phosphorylated; spermidine enhances translation [Source:SGD;Acc:S000003155]
G	YGL188C	YGL188C	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003156]
G	YGL188C-A	YGL188C-A	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000028635]
G	YGL189C	RPS26A	3274	-371.1	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps26Bp and has similarity to rat S26 ribosomal protein [Source:SGD;Acc:S000003157]
G	YGL190C	CDC55	973	-1331.9	4	Non-essential regulatory subunit B of protein phosphatase 2A (PP2A); involved in regulation of mitotic exit; required for correct nuclear division and chromosome segregation in meiosis; maintains sequestration of the phosphatase Cdc14p in nucleolus    early meiosis, which is essential for meiosis I spindle assembly; limits formation of PP2A-Rts1p holocomplexes to ensure timely dissolution of sister chromosome cohesion; found in nucleus, bud neck and bud of most cells [Source:SGD;Acc:S000003158]
G	YGL191W	COX13	711	-168.4	4	Subunit VIa of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP [Source:SGD;Acc:S000003159]
G	YGL192W	IME4	10	-28	2	Probable mRNA N6-adenosine methyltransferase required for entry into meiosis; transcribed in diploid cells; haploids repress IME4 transcription via production of antisense IME4 transcripts; antisense transcription is repressed in diploids [Source:SGD;Acc:S000003160]
G	YGL193C	YGL193C	2	-2.6	2	Haploid-specific gene repressed by a1-alpha2, turned off in sir3 null strains, absence enhances the sensitivity of rad52-327 cells to campothecin almost 100-fold [Source:SGD;Acc:S000003161]
G	YGL194C	HOS2	159	-135	4	Histone deacetylase required for gene activation via specific deacetylation of lysines in H3 and H4 histone tails; subunit of the Set3 complex, a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity [Source:SGD;Acc:S000003162]
G	YGL194C-A	YGL194C-A	9	-10.2	4	Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species [Source:SGD;Acc:S000087160]
G	YGL195W	GCN1	3066	-2793.7	4	Positive regulator of the Gcn2p kinase activity, forms a complex with Gcn20p; proposed to stimulate Gcn2p activation by an uncharged tRNA [Source:SGD;Acc:S000003163]
G	YGL196W	DSD1	626	-426.8	4	D-serine dehydratase (aka D-serine ammonia-lyase); converts D-serine to pyruvate and ammonia by a reaction dependent on pyridoxal 5'-phosphate and zinc; may play a role in D-serine detoxification; L-serine is not a substrate [Source:SGD;Acc:S000003164]
G	YGL197W	MDS3	939	-608.6	4	Putative component of the TOR regulatory pathway; negative regulator of early meiotic gene expression; required, with Pmd1p, for growth under alkaline conditions; has an N-terminal kelch-like domain [Source:SGD;Acc:S000003165]
G	YGL198W	YIP4	294	-86.1	4	Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport [Source:SGD;Acc:S000003166]
G	YGL199C	YGL199C	4	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W [Source:SGD;Acc:S000003167]
G	YGL200C	EMP24	1180	-309.4	4	Component of the p24 complex; binds to GPI anchor proteins and mediates their efficient transport from the ER to the Golgi; integral membrane protein that associates with endoplasmic reticulum-derived COPII-coated vesicles [Source:SGD;Acc:S000003168]
G	YGL201C	MCM6	1341	-925.3	4	Protein involved in DNA replication; component of the Mcm2-7 hexameric complex that binds chromatin as a part of the pre-replicative complex; forms a subcomplex with Mcm4p and Mcm7p [Source:SGD;Acc:S000003169]
G	YGL202W	ARO8	3172	-1020.8	4	Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis [Source:SGD;Acc:S000003170]
G	YGL203C	KEX1	767	-410.3	4	Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins [Source:SGD;Acc:S000003171]
G	YGL204C	YGL204C	12	-20.3	4	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003172]
G	YGL205W	POX1	353	-565.3	4	Fatty-acyl coenzyme A oxidase, involved in the fatty acid beta-oxidation pathway; localized to the peroxisomal matrix [Source:SGD;Acc:S000003173]
G	YGL206C	CHC1	3614	-2661.1	4	Clathrin heavy chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; two heavy chains form the clathrin triskelion structural component; the light chain (CLC1) is thought to regulate function [Source:SGD;Acc:S000003174]
G	YGL207W	SPT16	2586	-892.6	4	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases [Source:SGD;Acc:S000003175]
G	YGL208W	SIP2	354	-955.6	4	One of three beta subunits of the Snf1 serine/threonine protein kinase complex involved in the response to glucose starvation; null mutants exhibit accelerated aging; N-myristoylprotein localized to the cytoplasm and the plasma membrane [Source:SGD;Acc:S000003176]
G	YGL209W	MIG2	42	-46.3	3	Protein containing zinc fingers, involved in repression, along with Mig1p, of SUC2 (invertase) expression by high levels of glucose; binds to Mig1p-binding sites in SUC2 promoter [Source:SGD;Acc:S000003177]
G	YGL210W	YPT32	1899	-256	4	Rab family GTPase, very similar to Ypt31p; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi [Source:SGD;Acc:S000003178]
G	YGL211W	NCS6	321	-120.2	4	Protein required for thiolation of the uridine at the wobble position of Gln, Lys, and Glu tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae [Source:SGD;Acc:S000003179]
G	YGL212W	VAM7	363	-148.5	4	Vacuolar SNARE protein that functions with Vam3p in vacuolar protein trafficking; has an N-terminal PX domain (phosphoinositide-binding module) that binds PtdIns-3-P and mediates membrane binding; SNAP-25 homolog [Source:SGD;Acc:S000003180]
G	YGL213C	SKI8	423	-152.5	4	Ski complex component and WD-repeat protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; also required for meiotic double-strand break recombination; null mutants have superkiller phenotype [Source:SGD;Acc:S000003181]
G	YGL214W	YGL214W	2	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion mutation phenotype is likely due to the overlapping verified ORF SKI8/YGL213C [Source:SGD;Acc:S000003182]
G	YGL215W	CLG1	17	-1287.1	4	Cyclin-like protein that interacts with Pho85p; has sequence similarity to G1 cyclins PCL1 and PCL2 [Source:SGD;Acc:S000003183]
G	YGL216W	KIP3	190	-119.3	4	Kinesin-related motor protein involved in mitotic spindle positioning [Source:SGD;Acc:S000003184]
G	YGL217C	YGL217C	8	-5	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W [Source:SGD;Acc:S000003185]
G	YGL218W	YGL218W	7	-2.5	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 93% of ORF overlaps the verified gene MDM34; deletion in cyr1 mutant results in loss of stress resistance [Source:SGD;Acc:S000003186]
G	YGL219C	MDM34	143	-109.1	4	Mitochondrial component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth [Source:SGD;Acc:S000003187]
G	YGL220W	FRA2	360	-62	4	Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; null mutant fails to repress iron regulon and is sensitive to nickel [Source:SGD;Acc:S000003188]
G	YGL221C	NIF3	1337	-398.3	4	Protein of unknown function, similar to Listeria monocytogenes major sigma factor (rpoD gene product); the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003189]
G	YGL222C	EDC1	215	-78.9	4	RNA-binding protein, activates mRNA decapping directly by binding to the mRNA substrate and enhancing the activity of the decapping proteins Dcp1p and Dcp2p; has a role in translation during heat stress [Source:SGD;Acc:S000003190]
G	YGL223C	COG1	288	-173.9	4	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000003191]
G	YGL224C	SDT1	317	-156.3	4	Pyrimidine nucleotidase; overexpression suppresses the 6-AU sensitivity of transcription elongation factor S-II, as well as resistance to other pyrimidine derivatives [Source:SGD;Acc:S000003192]
G	YGL225W	VRG4	326	-129.2	4	Golgi GDP-mannose transporter; regulates Golgi function and glycosylation in Golgi [Source:SGD;Acc:S000003193]
G	YGL226C-A	OST5	161	-48.6	4	Zeta subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins [Source:SGD;Acc:S000003194]
G	YGL226W	MTC3	57	-63.4	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; mtc3 is synthetically sick with cdc13-1 [Source:SGD;Acc:S000003195]
G	YGL227W	VID30	662	-1543.5	4	Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); binds FBPase; shifts the balance of nitrogen metabolism toward glutamate production; localizes to the nucleus and the cytoplasm [Source:SGD;Acc:S000003196]
G	YGL228W	SHE10	1262	-506.7	4	Putative glycosylphosphatidylinositol (GPI)-anchored protein of unknown function; overexpression causes growth arrest [Source:SGD;Acc:S000003197]
G	YGL229C	SAP4	140	-1095.9	4	Protein required for function of the Sit4p protein phosphatase, member of a family of similar proteins that form complexes with Sit4p, including Sap155p, Sap185p, and Sap190p [Source:SGD;Acc:S000003198]
G	YGL230C	YGL230C	11	-2.6	2	Putative protein of unknown function; non-essential gene [Source:SGD;Acc:S000003199]
G	YGL231C	EMC4	714	-190.3	4	Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response; human ortholog TMEM85 may function in apoptosis [Source:SGD;Acc:S000003200]
G	YGL232W	TAN1	861	-289.7	4	Putative tRNA acetyltransferase, RNA-binding protein required for the formation of the modified nucleoside N(4)-acetylcytidine in serine and leucine tRNAs but not required for the same modification in 18S rRNA [Source:SGD;Acc:S000003201]
G	YGL233W	SEC15	341	-453.3	4	Essential 113kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which mediates polarized targeting of vesicles to active sites of exocytosis; Sec15p associates with Sec4p and vesicles [Source:SGD;Acc:S000003202]
G	YGL234W	ADE5,7	3259	-1797.2	4	ADE5,7, Bifunctional enzyme of the 'de novo' purine nucleotide biosynthetic pathway, contains aminoimidazole ribotide synthetase and glycinamide ribotide synthetase activities [Source:SGD;Acc:S000003203]
G	YGL235W	YGL235W	4	-2.1	2	Putative protein of unknown function; potential Cdc28p substrate; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 [Source:SGD;Acc:S000003204]
G	YGL236C	MTO1	180	-156.7	4	Mitochondrial protein, forms a heterodimer complex with Mss1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; required for respiration in paromomycin-resistant 15S rRNA mutants [Source:SGD;Acc:S000003205]
G	YGL237C	HAP2	173	-128.4	4	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding [Source:SGD;Acc:S000003206]
G	YGL238W	CSE1	1369	-591.7	4	Nuclear envelope protein that mediates the nuclear export of importin alpha (Srp1p), homolog of metazoan CAS protein, required for accurate chromosome segregation [Source:SGD;Acc:S000003207]
G	YGL239C	YGL239C	3	-2.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene CSE1 [Source:SGD;Acc:S000003208]
G	YGL240W	DOC1	53	-91.4	4	Processivity factor required for the ubiquitination activity of the anaphase promoting complex (APC), mediates the activity of the APC by contributing to substrate recognition; involved in cyclin proteolysis; contains a conserved DOC1 homology domain [Source:SGD;Acc:S000003209]
G	YGL241W	KAP114	421	-355.2	4	Karyopherin, responsible for nuclear import of Spt15p, Sua7p, histones H2A and H2B, and Nap1p; amino terminus shows similarity to those of other importins, particularly Cse1p; localization is primarily nuclear [Source:SGD;Acc:S000003210]
G	YGL242C	YGL242C	1147	-242	4	Putative protein of unknown function; deletion mutant is viable [Source:SGD;Acc:S000003211]
G	YGL243W	TAD1	118	-202.8	4	tRNA-specific adenosine deaminase, deaminates adenosine-37 to inosine in tRNA-Ala [Source:SGD;Acc:S000003212]
G	YGL244W	RTF1	1016	-548.5	4	Subunit of RNAPII-associated chromatin remodeling Paf1 complex; regulates gene expression by directing cotranscriptional histone modification, influences transcription and chromatin structure through several independent functional domains; directly   irectly regulates DNA-binding properties of Spt15p and relative activities of different TATA elements; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay [Source:SGD;Acc:S000003213]
G	YGL245W	GUS1	3802	-1419.4	4	Glutamyl-tRNA synthetase (GluRS), forms a complex with methionyl-tRNA synthetase (Mes1p) and Arc1p; complex formation increases the catalytic efficiency of both tRNA synthetases and ensures their correct localization to the cytoplasm [Source:SGD;Acc:S000003214]
G	YGL246C	RAI1	717	-287.6	4	Nuclear protein with decapping endonuclease activity targeted toward mRNAs with unmethylated 7-methylguanosine cap structures; binds to and stabilizes the exoribonuclease Rat1p; required for pre-rRNA processing; homologous to human DOM3Z [Source:SGD;Acc:S000003215]
G	YGL247W	BRR6	34	-27.9	4	Essential nuclear envelope integral membrane protein required for nuclear envelope morphology, nuclear pore complex localization, nuclear export; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism [Source:SGD;Acc:S000003216]
G	YGL248W	PDE1	310	-155.4	4	Low-affinity cyclic AMP phosphodiesterase, controls glucose and intracellular acidification-induced cAMP signaling, target of the cAMP-protein kinase A (PKA) pathway; glucose induces transcription and inhibits translation [Source:SGD;Acc:S000003217]
G	YGL249W	ZIP2	65	-2.3	2	Meiosis-specific protein involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis [Source:SGD;Acc:S000003218]
G	YGL250W	RMR1	86	-96.6	4	Protein required for meiotic recombination and gene conversion; null mutant displays reduced PIS1 expression and growth defects on non-fermentable carbon sources and minimal media; GFP-fusion protein localizes to both cytoplasm and nucleus [Source:SGD;Acc:S000003219]
G	YGL251C	HFM1	36	-26	2	Meiosis specific DNA helicase involved in the conversion of double-stranded breaks to later recombination intermediates and in crossover control; catalyzes the unwinding of Holliday junctions; has ssDNA and dsDNA stimulated ATPase activity [Source:SGD;Acc:S000003220]
G	YGL252C	RTG2	1067	-506.7	4	Sensor of mitochondrial dysfunction; regulates the subcellular location of Rtg1p and Rtg3p, transcriptional activators of the retrograde (RTG) and TOR pathways; Rtg2p is inhibited by the phosphorylated form of Mks1p [Source:SGD;Acc:S000003221]
G	YGL253W	HXK2	4182	-1277.8	4	Hexokinase isoenzyme 2 that catalyzes phosphorylation of glucose in the cytosol; predominant hexokinase during growth on glucose; functions in the nucleus to repress expression of HXK1 and GLK1 and to induce expression of its own gene [Source:SGD;Acc:S000003222]
G	YGL254W	FZF1	94	-86.4	4	Transcription factor involved in sulfite metabolism, sole identified regulatory target is SSU1, overexpression suppresses sulfite-sensitivity of many unrelated mutants due to hyperactivation of SSU1, contains five zinc fingers [Source:SGD;Acc:S000003223]
G	YGL255W	ZRT1	583	-362.8	4	High-affinity zinc transporter of the plasma membrane, responsible for the majority of zinc uptake; transcription is induced under low-zinc conditions by the Zap1p transcription factor [Source:SGD;Acc:S000003224]
G	YGL256W	ADH4	502	-922.6	4	Alcohol dehydrogenase isoenzyme type IV, dimeric enzyme demonstrated to be zinc-dependent despite sequence similarity to iron-activated alcohol dehydrogenases; transcription is induced in response to zinc deficiency [Source:SGD;Acc:S000003225]
G	YGL257C	MNT2	70	-123.6	4	Mannosyltransferase involved in adding the 4th and 5th mannose residues of O-linked glycans [Source:SGD;Acc:S000003226]
G	YGL258W	VEL1	8	-33.4	4	Protein of unknown function; highly induced in zinc-depleted conditions and has increased expression in NAP1 deletion mutants [Source:SGD;Acc:S000003227]
G	YGL258W-A	YGL258W-A	7	-7.7	2	Putative protein of unknown function [Source:SGD;Acc:S000007607]
G	YGL259W	YPS5	2	-2.4	2	Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p [Source:SGD;Acc:S000003228]
G	YGL260W	YGL260W	9	-3	2	Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium [Source:SGD;Acc:S000003229]
G	YGL261C	PAU11	2	-1.1	1	Putative protein of unknown function and member of the seripauperin multigene family encoded mainly in subtelomeric regions; mRNA expression appears to be regulated by SUT1 and UPC2 [Source:SGD;Acc:S000003230]
G	YGL262W	YGL262W	4	-1.8	1	Putative protein of unknown function; null mutant displays elevated sensitivity to expression of a mutant huntingtin fragment or of alpha-synuclein; YGL262W is not an essential gene [Source:SGD;Acc:S000003231]
G	YGL263W	COS12	17	-14.1	2	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000003232]
G	YGR001C	AML1	1071	-178	4	Putative protein of unknown function with similarity to methyltransferase family members; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; required for replication of Brome mosaic virus in S. cerevisiae [Source:SGD;Acc:S000003233]
G	YGR002C	SWC4	377	-1886.4	4	Component of the Swr1p complex that incorporates Htz1p into chromatin; component of the NuA4 histone acetyltransferase complex [Source:SGD;Acc:S000003234]
G	YGR003W	CUL3	167	-230.4	4	Ubiquitin-protein ligase, forms a complex with Elc1p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; cullin family member with similarity to Cdc53p and human CUL3 [Source:SGD;Acc:S000003235]
G	YGR004W	PEX31	160	-164.9	4	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome size; partially functionally redundant with Pex30p and Pex32p; probably acts at a step downstream of steps mediated by Pex28p and Pex29p [Source:SGD;Acc:S000003236]
G	YGR005C	TFG2	759	-268.2	4	TFIIF (Transcription Factor II) middle subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP30 [Source:SGD;Acc:S000003237]
G	YGR006W	PRP18	173	-150.6	4	Splicing factor involved in the positioning of the 3' splice site during the second catalytic step of splicing, part of snRNP U5, interacts with Slu7p [Source:SGD;Acc:S000003238]
G	YGR007W	ECT1	332	-114.8	4	Ethanolamine-phosphate cytidylyltransferase, catalyzes the second step of phosphatidylethanolamine biosynthesis; involved in the maintenance of plasma membrane; similar to mammalian CTP: phosphocholine cytidylyl-transferases [Source:SGD;Acc:S000003239]
G	YGR008C	STF2	506	-130.6	4	Protein involved in regulation of the mitochondrial F1F0-ATP synthase; Stf1p and Stf2p may act as stabilizing factors that enhance inhibitory action of the Inh1p protein [Source:SGD;Acc:S000003240]
G	YGR009C	SEC9	935	-505.1	4	t-SNARE protein important for fusion of secretory vesicles with the plasma membrane; similar to but not functionally redundant with Spo20p; SNAP-25 homolog [Source:SGD;Acc:S000003241]
G	YGR010W	NMA2	444	-206.2	4	Nicotinic acid mononucleotide adenylyltransferase, involved in de novo and salvage synthesis of NAD(+) [Source:SGD;Acc:S000003242]
G	YGR011W	YGR011W	1	-2.4	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003243]
G	YGR012W	YGR012W	747	-373	4	Putative cysteine synthase, localized to the mitochondrial outer membrane [Source:SGD;Acc:S000003244]
G	YGR013W	SNU71	356	-537	4	Component of U1 snRNP required for mRNA splicing via spliceosome; yeast specific, no metazoan counterpart [Source:SGD;Acc:S000003245]
G	YGR014W	MSB2	131	-51.4	4	Mucin family member involved in the Cdc42p- and MAP kinase-dependent filamentous growth signaling pathway; also functions as an osmosensor in parallel to the Sho1p-mediated pathway; potential Cdc28p substrate [Source:SGD;Acc:S000003246]
G	YGR015C	YGR015C	18	-68.7	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion [Source:SGD;Acc:S000003247]
G	YGR016W	YGR016W	27	-21.4	4	Putative protein of unknown function [Source:SGD;Acc:S000003248]
G	YGR017W	YGR017W	491	-135.3	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm [Source:SGD;Acc:S000003249]
G	YGR018C	YGR018C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR017W [Source:SGD;Acc:S000003250]
G	YGR019W	UGA1	1147	-776.3	4	Gamma-aminobutyrate (GABA) transaminase (4-aminobutyrate aminotransferase) involved in the 4-aminobutyrate and glutamate degradation pathways; required for normal oxidative stress tolerance and nitrogen utilization [Source:SGD;Acc:S000003251]
G	YGR020C	VMA7	970	-227.7	4	Subunit F of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane [Source:SGD;Acc:S000003252]
G	YGR021W	YGR021W	184	-99.7	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003253]
G	YGR022C	YGR022C	2	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W [Source:SGD;Acc:S000003254]
G	YGR023W	MTL1	67	-57.8	4	Putative plasma membrane sensor, involved in cell integrity signaling and stress response during glucose starvation and oxidative stress; has structural and functional similarity to Mid2p [Source:SGD;Acc:S000003255]
G	YGR024C	THG1	179	-132.1	4	tRNAHis guanylyltransferase, adds a guanosine residue to the 5' end of tRNAHis after transcription and RNase P cleavage; couples nuclear division and migration to cell budding and cytokinesis; essential enzyme conserved among eukaryotes [Source:SGD;Acc:S000003256]
G	YGR025W	YGR025W	4	-2.1	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003257]
G	YGR026W	YGR026W	234	-98.8	3	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000003258]
G	YGR027C	RPS25A	3333	-333.4	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Bp and has similarity to rat S25 ribosomal protein [Source:SGD;Acc:S000003259]
G	YGR027W-A	YGR027W-A	4662	-1713.4	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007405]
G	YGR027W-B	YGR027W-B	4973	-2384.6	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007406]
G	YGR028W	MSP1	354	-263.8	4	Mitochondrial protein involved in sorting of proteins in the mitochondria; putative membrane-spanning ATPase [Source:SGD;Acc:S000003260]
G	YGR029W	ERV1	509	-137.8	4	Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR) [Source:SGD;Acc:S000003261]
G	YGR030C	POP6	157	-50.8	4	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs [Source:SGD;Acc:S000003262]
G	YGR031C-A	NAG1	2	-1.6	1	Protein involved in yeast cell wall biogenesis; localizes to the cell periphery; production of Nag1p is dependent upon the presence of Slt2p and Rlm1p; gene is nested within and antisense to IMO32 [Source:SGD;Acc:S000028636]
G	YGR031W	IMO32	330	-184.6	4	Conserved mitochondrial protein of unknown function; processed by both mitochondrial processing peptidase and mitochondrial octapeptidyl aminopeptidase; gene contains the nested antisense gene NAG1 [Source:SGD;Acc:S000003263]
G	YGR032W	GSC2	2704	-1151.8	4	Catalytic subunit of 1,3-beta-glucan synthase, involved in formation of the inner layer of the spore wall; activity positively regulated by Rho1p and negatively by Smk1p; has similarity to an alternate catalytic subunit, Fks1p (Gsc1p) [Source:SGD;Acc:S000003264]
G	YGR033C	TIM21	350	-81.6	4	Nonessential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); interacts with the Translocase of the Outer Mitochondrial membrane (TOM complex) and with respiratory enzymes; may regulate TIM23 complex activity [Source:SGD;Acc:S000003265]
G	YGR034W	RPL26B	3816	-419.2	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Ap and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA [Source:SGD;Acc:S000003266]
G	YGR035C	YGR035C	10	-10.1	2	Putative protein of unknown function, potential Cdc28p substrate; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance [Source:SGD;Acc:S000003267]
G	YGR035W-A	YGR035W-A	3	-2.7	2	Putative protein of unknown function [Source:SGD;Acc:S000028827]
G	YGR036C	CAX4	12	-30.3	4	Dolichyl pyrophosphate (Dol-P-P) phosphatase with a luminally oriented active site in the ER, cleaves the anhydride linkage in Dol-P-P, required for Dol-P-P-linked oligosaccharide intermediate synthesis and protein N-glycosylation [Source:SGD;Acc:S000003268]
G	YGR037C	ACB1	1739	-221.7	4	Acyl-CoA-binding protein, transports newly synthesized acyl-CoA esters from fatty acid synthetase (Fas1p-Fas2p) to acyl-CoA-consuming processes; subject to starvation-induced, Grh1p-mediated unconventional secretion [Source:SGD;Acc:S000003269]
G	YGR038C-A	YGR038C-A	4604	-1660.2	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007407]
G	YGR038C-B	YGR038C-B	4910	-2337.9	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007408]
G	YGR038W	ORM1	577	-129.7	4	Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control [Source:SGD;Acc:S000003270]
G	YGR039W	YGR039W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722 [Source:SGD;Acc:S000003271]
G	YGR040W	KSS1	492	-958.4	4	Mitogen-activated protein kinase (MAPK) involved in signal transduction pathways that control filamentous growth and pheromone response; the KSS1 gene is nonfunctional in S288C strains and functional in W303 strains [Source:SGD;Acc:S000003272]
G	YGR041W	BUD9	105	-128.9	4	Protein involved in bud-site selection; mutant has increased aneuploidy tolerance; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the distal pole [Source:SGD;Acc:S000003273]
G	YGR042W	YGR042W	54	-59.9	4	Putative protein of unknown function; involved in maintenance of proper telomere length; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000003274]
G	YGR043C	NQM1	1086	-354.3	4	Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift [Source:SGD;Acc:S000003275]
G	YGR044C	RME1	140	-57.7	4	Zinc finger protein involved in control of meiosis; prevents meiosis by repressing IME1 expression and promotes mitosis by activating CLN2 expression; directly repressed by a1-alpha2 regulator; mediates cell type control of sporulation [Source:SGD;Acc:S000003276]
G	YGR045C	YGR045C	4	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003277]
G	YGR046W	TAM41	88	-232.4	4	Mitochondrial protein involved in protein import into the mitochondrial matrix; maintains the functional integrity of the TIM23 protein translocator complex; viability of null mutant is strain-dependent; mRNA is targeted to the bud [Source:SGD;Acc:S000003278]
G	YGR047C	TFC4	351	-354.8	4	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102 [Source:SGD;Acc:S000003279]
G	YGR048W	UFD1	742	-257.4	4	Protein that interacts with Cdc48p and Npl4p, involved in recognition of polyubiquitinated proteins and their presentation to the 26S proteasome for degradation; involved in transporting proteins from the ER to the cytosol [Source:SGD;Acc:S000003280]
G	YGR049W	SCM4	272	-53	4	Mitochondrial outer membrane protein of unknown function; predicted to have 4 transmembrane segments; import is mediated by Tom70p and Mim1p; interacts genetically with a cdc4 mutation [Source:SGD;Acc:S000003281]
G	YGR050C	YGR050C	7	-3.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003282]
G	YGR051C	YGR051C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YGR051C is not an essential gene [Source:SGD;Acc:S000003283]
G	YGR052W	FMP48	17	-881.9	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000003284]
G	YGR053C	YGR053C	34	-82.3	4	Putative protein of unknown function [Source:SGD;Acc:S000003285]
G	YGR054W	YGR054W	2562	-689.7	4	Eukaryotic initiation factor (eIF) 2A; associates specifically with both 40S subunits and 80 S ribosomes, and interacts genetically with both eIF5b and eIF4E; homologous to mammalian eIF2A [Source:SGD;Acc:S000003286]
G	YGR055W	MUP1	438	-104.5	4	High affinity methionine permease, integral membrane protein with 13 putative membrane-spanning regions; also involved in cysteine uptake [Source:SGD;Acc:S000003287]
G	YGR056W	RSC1	436	-258.4	4	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook [Source:SGD;Acc:S000003288]
G	YGR057C	LST7	36	-77	4	Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface [Source:SGD;Acc:S000003289]
G	YGR058W	PEF1	176	-174.8	4	Penta-EF-hand protein required for polar bud growth and cell wall abscission; binds calcium and zinc with different affinity; localizes to bud site in G1, bud neck in G2 [Source:SGD;Acc:S000003290]
G	YGR059W	SPR3	29	-21.9	2	Sporulation-specific homolog of the yeast CDC3/10/11/12 family of bud neck microfilament genes; septin protein involved in sporulation; regulated by ABFI [Source:SGD;Acc:S000003291]
G	YGR060W	ERG25	648	-206.6	4	C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol [Source:SGD;Acc:S000003292]
G	YGR061C	ADE6	3025	-2751.9	4	Formylglycinamidine-ribonucleotide (FGAM)-synthetase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway [Source:SGD;Acc:S000003293]
G	YGR062C	COX18	12	-38.2	2	Mitochondrial integral inner membrane protein required for membrane insertion of C-terminus of Cox2p; interacts genetically and physically with Mss2p and Pnt1p; similar to S. cerevisiae Oxa1, N. crassa Oxa2p, and E. coli YidC [Source:SGD;Acc:S000003294]
G	YGR063C	SPT4	339	-80.3	4	Protein involved in the regulating Pol I and Pol II transcription, pre-mRNA processing, kinetochore function, and gene silencing; forms a complex with Spt5p [Source:SGD;Acc:S000003295]
G	YGR064W	YGR064W	1	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SPT4/YGR063C [Source:SGD;Acc:S000003296]
G	YGR065C	VHT1	197	-215.3	4	High-affinity plasma membrane H+-biotin (vitamin H) symporter; mutation results in fatty acid auxotrophy; 12 transmembrane domain containing major facilitator subfamily member; mRNA levels negatively regulated by iron deprivation and biotin [Source:SGD;Acc:S000003297]
G	YGR066C	YGR066C	5	-2.2	2	Putative protein of unknown function [Source:SGD;Acc:S000003298]
G	YGR067C	YGR067C	59	-172.6	4	Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p [Source:SGD;Acc:S000003299]
G	YGR068C	ART5	327	-507.8	4	Protein proposed to regulate the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target in the plasma membrane [Source:SGD;Acc:S000003300]
G	YGR068W-A	YGR068W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with the uncharacterized ORF YGR068C [Source:SGD;Acc:S000028637]
G	YGR069W	YGR069W	2	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003301]
G	YGR070W	ROM1	216	-102.4	4	GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP [Source:SGD;Acc:S000003302]
G	YGR071C	ENV11	114	-184.4	4	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein loc   to the nucleus [Source:SGD;Acc:S000003303]
G	YGR072W	UPF3	456	-157.8	4	Component of the nonsense-mediated mRNA decay (NMD) pathway, along with Nam7p and Nmd2p; involved in decay of mRNA containing nonsense codons; involved in telomere maintenance [Source:SGD;Acc:S000003304]
G	YGR073C	YGR073C	2	-11.3	2	Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein [Source:SGD;Acc:S000003305]
G	YGR074W	SMD1	487	-88	4	Core Sm protein Sm D1; part of heteroheptameric complex (with Smb1p, Smd2p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D1 [Source:SGD;Acc:S000003306]
G	YGR075C	PRP38	113	-76.2	4	Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly [Source:SGD;Acc:S000003307]
G	YGR076C	MRPL25	293	-102.1	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000003308]
G	YGR077C	PEX8	122	-170.9	4	Intraperoxisomal organizer of the peroxisomal import machinery, tightly associated with the lumenal face of the peroxisomal membrane, essential for peroxisome biogenesis, binds PTS1-signal receptor Pex5p [Source:SGD;Acc:S000003309]
G	YGR078C	PAC10	737	-104.7	4	Part of the heteromeric co-chaperone GimC/prefoldin complex, which promotes efficient protein folding [Source:SGD;Acc:S000003310]
G	YGR079W	YGR079W	17	-4.9	2	Putative protein of unknown function; YGR079W is not an essential gene [Source:SGD;Acc:S000003311]
G	YGR080W	TWF1	1196	-758.6	4	Twinfilin, highly conserved actin monomer-sequestering protein involved in regulation of the cortical actin cytoskeleton, composed of two cofilin-like regions, localizes actin monomers to sites of rapid filament assembly [Source:SGD;Acc:S000003312]
G	YGR081C	SLX9	434	-115.7	4	Protein required for pre-rRNA processing; associated with the 90S pre-ribosome and 43S small ribosomal subunit precursor; interacts with U3 snoRNA; deletion mutant has synthetic fitness defect with an sgs1 deletion mutant [Source:SGD;Acc:S000003313]
G	YGR082W	TOM20	1656	-188.4	4	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins [Source:SGD;Acc:S000003314]
G	YGR083C	GCD2	1155	-515.8	4	Delta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression [Source:SGD;Acc:S000003315]
G	YGR084C	MRP13	572	-311.7	4	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000003316]
G	YGR085C	RPL11B	4477	-409.9	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl11Ap; involved in ribosomal assembly; depletion causes degradation of proteins and RNA of the 60S subunit; has similarity to E. coli L5 and rat L11 [Source:SGD;Acc:S000003317]
G	YGR086C	PIL1	3800	-1254.1	4	Primary component of eisosomes, which are large immobile cell cortex structures associated with endocytosis; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; detected in phosphorylated state in mitochondria; member of the BAR    family [Source:SGD;Acc:S000003318]
G	YGR087C	PDC6	4680	-1322.6	4	Minor isoform of pyruvate decarboxylase, decarboxylates pyruvate to acetaldehyde, involved in amino acid catabolism; transcription is glucose- and ethanol-dependent, and is strongly induced during sulfur limitation [Source:SGD;Acc:S000003319]
G	YGR088W	CTT1	991	-748.5	4	Cytosolic catalase T, has a role in protection from oxidative damage by hydrogen peroxide [Source:SGD;Acc:S000003320]
G	YGR089W	NNF2	289	-184.9	4	Protein that exhibits physical and genetic interactions with Rpb8p, which is a subunit of RNA polymerases I, II, and III; computational analysis of large-scale protein-protein interaction data suggests a role in chromosome segregation [Source:SGD;Acc:S000003321]
G	YGR090W	UTP22	2239	-857.1	4	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data [Source:SGD;Acc:S000003322]
G	YGR091W	PRP31	178	-190.1	4	Splicing factor, component of the U4/U6-U5 snRNP complex [Source:SGD;Acc:S000003323]
G	YGR092W	DBF2	408	-1414.2	4	Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis [Source:SGD;Acc:S000003324]
G	YGR093W	DRN1	287	-170.5	4	Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus [Source:SGD;Acc:S000003325]
G	YGR094W	VAS1	3425	-2109.9	4	Mitochondrial and cytoplasmic valyl-tRNA synthetase [Source:SGD;Acc:S000003326]
G	YGR095C	RRP46	582	-439.5	4	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp46p (EXOSC5) [Source:SGD;Acc:S000003327]
G	YGR096W	TPC1	44	-99	4	Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family [Source:SGD;Acc:S000003328]
G	YGR097W	ASK10	1016	-3492.7	4	Component of RNA polymerase II holoenzyme, phosphorylated in response to oxidative stress; has a role in destruction of Ssn8p; proposed to function in activation of the glycerol channel Fps1p; paralogous to Rgc1p [Source:SGD;Acc:S000003329]
G	YGR098C	ESP1	91	-48.9	4	Separase, a caspase-like cysteine protease that promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p [Source:SGD;Acc:S000003330]
G	YGR099W	TEL2	141	-165	4	Essential DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect [Source:SGD;Acc:S000003331]
G	YGR100W	MDR1	692	-400.2	4	Cytoplasmic GTPase-activating protein for Ypt/Rab transport GTPases Ypt6p, Ypt31p and Sec4p; involved in recycling of internalized proteins and regulation of Golgi secretory function [Source:SGD;Acc:S000003332]
G	YGR101W	PCP1	32	-23	3	Mitochondrial serine protease required for the processing of various mitochondrial proteins and maintenance of mitochondrial DNA and morphology; belongs to the rhomboid-GlpG superfamily of intramembrane peptidases [Source:SGD;Acc:S000003333]
G	YGR102C	GTF1	89	-92.2	4	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria [Source:SGD;Acc:S000003334]
G	YGR103W	NOP7	2094	-422.3	4	Component of several different pre-ribosomal particles; forms a complex with Ytm1p and Erb1p that is required for maturation of the large ribosomal subunit; required for exit from G<sub>0</sub> and the initiation of cell proliferation [Source:SGD;Acc:S000003335]
G	YGR104C	SRB5	243	-164.8	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; required for proper termination of transcription for some genes; involved  lomere maintenance [Source:SGD;Acc:S000003336]
G	YGR105W	VMA21	20	-16.2	3	Integral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) [Source:SGD;Acc:S000003337]
G	YGR106C	VOA1	247	-82.5	4	Endoplasmic reticulum protein that functions, together with other assembly factors, in assembly of the V0 sector of the vacuolar ATPase (V-ATPase); null mutation enhances the V-ATPase deficiency of a vma21 mutant impaired in ER retrieval [Source:SGD;Acc:S000003338]
G	YGR107W	YGR107W	3	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003339]
G	YGR108W	CLB1	46	-143.8	2	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome [Source:SGD;Acc:S000003340]
G	YGR109C	CLB6	50	-774.7	4	B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 [Source:SGD;Acc:S000003341]
G	YGR109W-A	YGR109W-A	118	-112	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007346]
G	YGR109W-B	YGR109W-B	193	-134.1	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007347]
G	YGR110W	CLD1	57	-234	4	Mitochondrial cardiolipin-specific phospholipase; functions upstream of Taz1p to generate monolyso-cardiolipin; transcription increases upon genotoxic stress; involved in restricting Ty1 transposition; has homology to mammalian CGI-58 [Source:SGD;Acc:S000003342]
G	YGR111W	YGR111W	636	-326.8	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000003343]
G	YGR112W	SHY1	238	-295.2	4	Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome [Source:SGD;Acc:S000003344]
G	YGR113W	DAM1	197	-180.8	4	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; Ipl1p target for regulating kinetochore-MT attachments [Source:SGD;Acc:S000003345]
G	YGR114C	YGR114C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps 5' end of the essential gene SPT6 [Source:SGD;Acc:S000003346]
G	YGR115C	YGR115C	3	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified and essential ORF SPT6/YGR115C [Source:SGD;Acc:S000003347]
G	YGR116W	SPT6	2327	-1104.3	4	Nucleosome remodeling protein; functions in various aspects of transcription, chromatin maintenance, and RNA processing; required for the maintenance of chromatin structure during transcription in order to inhibit transcription from promoters within  oding region [Source:SGD;Acc:S000003348]
G	YGR117C	YGR117C	554	-196	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003349]
G	YGR118W	RPS23A	3313	-300	4	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Bp and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal [Source:SGD;Acc:S000003350]
G	YGR119C	NUP57	1198	-594.2	4	Nucleoporin, essential subunit of the nuclear pore complex (NPC), functions as the organizing center of an NPC subcomplex containing Nsp1p, Nup49p, Nup57p, and Nic96p [Source:SGD;Acc:S000003351]
G	YGR120C	COG2	232	-175.4	4	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000003352]
G	YGR121C	MEP1	71	-32	3	Ammonium permease; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation [Source:SGD;Acc:S000003353]
G	YGR121W-A	YGR121W-A	1	0	1	Putative protein of unknown function [Source:SGD;Acc:S000028550]
G	YGR122C-A	YGR122C-A	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, similar to YLR334C and YOL106W [Source:SGD;Acc:S000007240]
G	YGR122W	YGR122W	233	-178	4	Probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic [Source:SGD;Acc:S000003354]
G	YGR123C	PPT1	948	-694	4	Protein serine/threonine phosphatase with similarity to human phosphatase PP5; present in both the nucleus and cytoplasm; expressed during logarithmic growth; computational analyses suggest roles in phosphate metabolism and rRNA processing [Source:SGD;Acc:S000003355]
G	YGR124W	ASN2	3471	-1031.2	4	Asparagine synthetase, isozyme of Asn1p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway [Source:SGD;Acc:S000003356]
G	YGR125W	YGR125W	643	-275	4	Putative protein of unknown function; deletion mutant has decreased rapamycin resistance but normal wormannin resistance; green fluorescent protein (GFP)-fusion protein localizes to the vacuole [Source:SGD;Acc:S000003357]
G	YGR126W	YGR126W	308	-100.1	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000003358]
G	YGR127W	YGR127W	290	-238.8	4	Putative protein of unknown function; expression is regulated by Msn2p/Msn4p, indicating a possible role in stress response [Source:SGD;Acc:S000003359]
G	YGR128C	UTP8	1447	-360.4	4	Nucleolar protein required for export of tRNAs from the nucleus; also copurifies with the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [Source:SGD;Acc:S000003360]
G	YGR129W	SYF2	244	-101.3	4	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; isy1 syf2 cells have defective spindles activiating cell cycle arrest [Source:SGD;Acc:S000003361]
G	YGR130C	YGR130C	2014	-836.7	4	Component of the eisosome with unknown function; GFP-fusion protein localizes to the cytoplasm; specifically phosphorylated in vitro by mammalian diphosphoinositol pentakisphosphate (IP7) [Source:SGD;Acc:S000003362]
G	YGR131W	FHN1	10	-11.3	2	Protein of unknown function; induced by ketoconazole; promoter region contains sterol regulatory element motif, which has been identified as a Upc2p-binding site; overexpression complements function of Nce102p in NCE102 deletion strain [Source:SGD;Acc:S000003363]
G	YGR132C	PHB1	1622	-364.7	4	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation [Source:SGD;Acc:S000003364]
G	YGR133W	PEX4	111	-42.1	4	Peroxisomal ubiquitin conjugating enzyme required for peroxisomal matrix protein import and peroxisome biogenesis [Source:SGD;Acc:S000003365]
G	YGR134W	CAF130	181	-231.9	4	Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation [Source:SGD;Acc:S000003366]
G	YGR135W	PRE9	1920	-380.1	4	Alpha 3 subunit of the 20S proteasome, the only nonessential 20S subunit; may be replaced by the alpha 4 subunit (Pre6p) under stress conditions to create a more active proteasomal isoform [Source:SGD;Acc:S000003367]
G	YGR136W	LSB1	797	-172.9	4	Protein containing an N-terminal SH3 domain; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization [Source:SGD;Acc:S000003368]
G	YGR137W	YGR137W	1	-2.2	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003369]
G	YGR138C	TPO2	334	-65.6	4	Polyamine transport protein specific for spermine; localizes to the plasma membrane; transcription of TPO2 is regulated by Haa1p; member of the major facilitator superfamily [Source:SGD;Acc:S000003370]
G	YGR139W	YGR139W	1	-2.9	2	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003371]
G	YGR140W	CBF2	280	-292.1	4	Essential kinetochore protein, component of the CBF3 multisubunit complex that binds to the CDEIII region of the centromere; Cbf2p also binds to the CDEII region possibly forming a different multimeric complex, ubiquitinated in vivo [Source:SGD;Acc:S000003372]
G	YGR141W	VPS62	79	-87.3	4	Vacuolar protein sorting (VPS) protein required for cytoplasm to vacuole targeting of proteins [Source:SGD;Acc:S000003373]
G	YGR142W	BTN2	112	-161	4	v-SNARE binding protein that facilitates specific protein retrieval from a late endosome to the Golgi; modulates arginine uptake, possible role in mediating pH homeostasis between the vacuole and plasma membrane H(+)-ATPase [Source:SGD;Acc:S000003374]
G	YGR143W	SKN1	473	-217.6	4	Protein involved in sphingolipid biosynthesis; type II membrane protein with similarity to Kre6p [Source:SGD;Acc:S000003375]
G	YGR144W	THI4	97	-252.2	4	Thiazole synthase, abundant protein involved in the formation of the thiazole moiety of thiamine during thiamine biosynthesis; acts more as a co-substrate rather than an enzyme by providing the sulphur source for thiazole formation; undergoes a sing  nover only; required for mitochondrial genome stability in response to DNA damaging agents [Source:SGD;Acc:S000003376]
G	YGR145W	ENP2	1285	-244	4	Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p [Source:SGD;Acc:S000003377]
G	YGR146C	ECL1	37	-12.1	2	Protein of unknown function, affects chronological lifespan; induced by iron homeostasis transcription factor Aft2p; multicopy suppressor of temperature sensitive hsf1 mutant; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000003378]
G	YGR146C-A	YGR146C-A	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000028638]
G	YGR147C	NAT2	286	-101.3	4	Protein with an apparent role in acetylation of N-terminal methionine residues [Source:SGD;Acc:S000003379]
G	YGR148C	RPL24B	3582	-346.7	4	Ribosomal protein L30 of the large (60S) ribosomal subunit, nearly identical to Rpl24Ap and has similarity to rat L24 ribosomal protein; not essential for translation but may be required for normal translation rate [Source:SGD;Acc:S000003380]
G	YGR149W	YGR149W	310	-110.6	4	Putative protein of unknown function; predicted to be an integal membrane protein [Source:SGD;Acc:S000003381]
G	YGR150C	CCM1	172	-241	4	Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport [Source:SGD;Acc:S000003382]
G	YGR151C	YGR151C	3	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF RSR1/BUD1/YGR152C [Source:SGD;Acc:S000003383]
G	YGR152C	RSR1	706	-106.3	4	GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases [Source:SGD;Acc:S000003384]
G	YGR153W	YGR153W	13	-2.1	2	Putative protein of unknown function [Source:SGD;Acc:S000003385]
G	YGR154C	GTO1	93	-172.7	4	Omega-class glutathione transferase; induced under oxidative stress; putative peroxisomal localization [Source:SGD;Acc:S000003386]
G	YGR155W	CYS4	4062	-1146.8	4	Cystathionine beta-synthase, catalyzes synthesis of cystathionine from serine and homocysteine, the first committed step in cysteine biosynthesis; responsible for hydrogen sulfide generation; mutations in human ortholog cause homocystinuria [Source:SGD;Acc:S000003387]
G	YGR156W	PTI1	633	-96	4	Essential protein that is a component of CPF (cleavage and polyadenylation factor); involved in 3' end formation of snoRNA and mRNA; interacts directly with Pta1p; has similarity to mammalian Cleavage-Stimulation Factor CstF-64 [Source:SGD;Acc:S000003388]
G	YGR157W	CHO2	1440	-349.3	4	Phosphatidylethanolamine methyltransferase (PEMT), catalyzes the first step in the conversion of phosphatidylethanolamine to phosphatidylcholine during the methylation pathway of phosphatidylcholine biosynthesis [Source:SGD;Acc:S000003389]
G	YGR158C	MTR3	415	-350.1	4	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hMtr3p (EXOSC6) [Source:SGD;Acc:S000003390]
G	YGR159C	NSR1	3236	-572.7	4	Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis [Source:SGD;Acc:S000003391]
G	YGR160W	YGR160W	3	-2	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003392]
G	YGR161C	RTS3	190	-355.1	4	Putative component of the protein phosphatase type 2A complex [Source:SGD;Acc:S000003393]
G	YGR161C-C	YGR161C-C	4589	-1612.1	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007367]
G	YGR161C-D	YGR161C-D	4917	-2253.3	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007368]
G	YGR161W-A	YGR161W-A	1045	-394.9	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007369]
G	YGR161W-B	YGR161W-B	2366	-922.5	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007370]
G	YGR161W-C	YGR161W-C	1	-6.7	2	Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species [Source:SGD;Acc:S000029726]
G	YGR162W	TIF4631	3088	-917	4	Translation initiation factor eIF4G, subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit [Source:SGD;Acc:S000003394]
G	YGR163W	GTR2	275	-89.7	4	Putative GTP binding protein that negatively regulates Ran/Tc4 GTPase cycle; activates transcription; subunit of EGO and GSE complexes; required for sorting of Gap1p; localizes to cytoplasm and to chromatin; homolog of human RagC and RagD [Source:SGD;Acc:S000003395]
G	YGR164W	YGR164W	1	-2.5	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003396]
G	YGR165W	MRPS35	532	-233.7	4	Mitochondrial ribosomal protein of the small subunit; null mutant does not grow on glycerol, is sensitive to 2,4-dichlorophenol, and accumulates large lipid droplets [Source:SGD;Acc:S000003397]
G	YGR166W	TRS65	198	-127.4	4	Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response [Source:SGD;Acc:S000003398]
G	YGR167W	CLC1	1357	-405.2	4	Clathrin light chain, subunit of the major coat protein involved in intracellular protein transport and endocytosis; thought to regulate clathrin function; two Clathrin heavy chains (CHC1) form the clathrin triskelion structural component [Source:SGD;Acc:S000003399]
G	YGR168C	YGR168C	166	-58.1	3	Putative protein of unknown function; YGR168C is not an essential gene [Source:SGD;Acc:S000003400]
G	YGR169C	PUS6	102	-181.8	4	tRNA:pseudouridine synthase, catalyzes the conversion of uridine to pseudouridine at position 31 in cytoplasmic and mitochondrial tRNAs; mutation of Asp168 to Ala abolishes enzyme activity; not essential for viability [Source:SGD;Acc:S000003401]
G	YGR169C-A	LSO2	921	-146.7	4	Putative protein of unknown function [Source:SGD;Acc:S000028521]
G	YGR170W	PSD2	313	-219.8	4	Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine [Source:SGD;Acc:S000003402]
G	YGR171C	MSM1	215	-241	4	Mitochondrial methionyl-tRNA synthetase (MetRS), functions as a monomer in mitochondrial protein synthesis; functions similarly to cytoplasmic MetRS although the cytoplasmic form contains a zinc-binding domain not found in Msm1p [Source:SGD;Acc:S000003403]
G	YGR172C	YIP1	153	-112.4	4	Integral membrane protein required for the biogenesis of ER-derived COPII transport vesicles; interacts with Yif1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF4 [Source:SGD;Acc:S000003404]
G	YGR173W	RBG2	1577	-303.1	4	Protein with a role in translation; forms a complex with Gir2p; has similarity to mammalian developmentally regulated GTP-binding protein [Source:SGD;Acc:S000003405]
G	YGR174C	CBP4	329	-118.4	4	Mitochondrial protein required for assembly of cytochrome bc1 complex; interacts with the Cbp3p-Cbp6p complex and newly synthesized cytochrome b (Cobp) to promote assembly of Cobp into the cytochrome bc1 complex [Source:SGD;Acc:S000003406]
G	YGR174W-A	YGR174W-A	0	nf	1	Putative protein of unknown function; predicted to have a role in cell budding based on computational guilt by association analysis [Source:SGD;Acc:S000028639]
G	YGR175C	ERG1	1822	-659.2	4	Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine [Source:SGD;Acc:S000003407]
G	YGR176W	YGR176W	2	-0.1	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003408]
G	YGR177C	ATF2	263	-206	4	Alcohol acetyltransferase, may play a role in steroid detoxification; forms volatile esters during fermentation, which is important for brewing and winemaking [Source:SGD;Acc:S000003409]
G	YGR178C	PBP1	2157	-546.5	4	Component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly; similar to human ataxin-2; interacts with Pab1p to regulate mRNA polyadenylation; interacts with Mkt1p to regulate HO translation [Source:SGD;Acc:S000003410]
G	YGR179C	OKP1	166	-177	4	Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly [Source:SGD;Acc:S000003411]
G	YGR180C	RNR4	3238	-948.2	4	Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits [Source:SGD;Acc:S000003412]
G	YGR181W	TIM13	1021	-160.3	4	Mitochondrial intermembrane space protein, forms a complex with Tim8p that delivers a subset of hydrophobic proteins to the TIM22 complex for insertion into the inner membrane [Source:SGD;Acc:S000003413]
G	YGR182C	YGR182C	31	-2.7	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TIM13/YGR181W [Source:SGD;Acc:S000003414]
G	YGR183C	QCR9	277	-68.3	4	Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex [Source:SGD;Acc:S000003415]
G	YGR184C	UBR1	951	-796.6	4	E3 ubiquitin ligase (N-recognin), forms heterodimer with Rad6p to ubiquitinate substrates in the N-end rule pathway; regulates peptide transport via Cup9p ubiquitination; mutation in human UBR1 causes Johansson-Blizzard Syndrome (JBS) [Source:SGD;Acc:S000003416]
G	YGR185C	TYS1	2840	-848.8	4	Cytoplasmic tyrosyl-tRNA synthetase, required for cytoplasmic protein synthesis; interacts with positions 34 and 35 of the tRNATyr anticodon; mutations in human ortholog YARS are associated with Charcot-Marie-Tooth (CMT) neuropathies [Source:SGD;Acc:S000003417]
G	YGR186W	TFG1	1418	-413.6	4	TFIIF (Transcription Factor II) largest subunit; involved in both transcription initiation and elongation of RNA polymerase II; homologous to human RAP74 [Source:SGD;Acc:S000003418]
G	YGR187C	HGH1	1159	-288.9	4	Nonessential protein of unknown function; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; similar to mammalian BRP16 (Brain protein 16) [Source:SGD;Acc:S000003419]
G	YGR188C	BUB1	101	-212.8	4	Protein kinase involved in the cell cycle checkpoint into anaphase; forms complex with Mad1p and Bub3p crucial to preventing cell cycle progression into anaphase in the presence of spindle damage; CDC28-mediated phosphorylation at Bub1p-T566 is impo  for its degradation in anaphase and adaptation of the checkpoint to prolonged mitotic arrest, but not to its kinase activity or chromosome segregation function; associates with centromere DNA via Skp1p [Source:SGD;Acc:S000003420]
G	YGR189C	CRH1	942	-183.7	4	Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress [Source:SGD;Acc:S000003421]
G	YGR190C	YGR190C	2	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene HIP1/YGR191W [Source:SGD;Acc:S000003422]
G	YGR191W	HIP1	411	-88.9	4	High-affinity histidine permease, also involved in the transport of manganese ions [Source:SGD;Acc:S000003423]
G	YGR192C	TDH3	7813	-3614.7	4	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 3, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall [Source:SGD;Acc:S000003424]
G	YGR193C	PDX1	1561	-439	4	Dihydrolipoamide dehydrogenase (E3)-binding protein (E3BP) of the mitochondrial pyruvate dehydrogenase (PDH) complex, plays a structural role in the complex by binding and positioning E3 to the dihydrolipoamide acetyltransferase (E2) core [Source:SGD;Acc:S000003425]
G	YGR194C	XKS1	555	-332.7	4	Xylulokinase, converts D-xylulose and ATP to xylulose 5-phosphate and ADP; rate limiting step in fermentation of xylulose; required for xylose fermentation by recombinant S. cerevisiae strains [Source:SGD;Acc:S000003426]
G	YGR195W	SKI6	419	-263.8	4	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase PH and to human hRrp41p (EXOSC4) [Source:SGD;Acc:S000003427]
G	YGR196C	FYV8	578	-425.7	4	Protein of unknown function, required for survival upon exposure to K1 killer toxin [Source:SGD;Acc:S000003428]
G	YGR197C	SNG1	223	-72.9	4	Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance [Source:SGD;Acc:S000003429]
G	YGR198W	YPP1	506	-356.7	4	Cargo-transport protein involved in endocytosis; interacts with phosphatidylinositol-4-kinase Stt4; GFP-fusion protein localizes to the cytoplasm; YGR198W is an essential gene [Source:SGD;Acc:S000003430]
G	YGR199W	PMT6	362	-301.6	4	Protein O-mannosyltransferase, transfers mannose from dolichyl phosphate-D-mannose to protein serine/threonine residues of secretory proteins; reaction is essential for cell wall rigidity; member of a family of mannosyltransferases [Source:SGD;Acc:S000003431]
G	YGR200C	ELP2	1208	-438.3	4	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; target of Kluyveromyces lactis zymocin [Source:SGD;Acc:S000003432]
G	YGR201C	YGR201C	287	-128.8	4	Putative protein of unknown function [Source:SGD;Acc:S000003433]
G	YGR202C	PCT1	892	-195.9	4	Cholinephosphate cytidylyltransferase, also known as CTP:phosphocholine cytidylyltransferase, rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding [Source:SGD;Acc:S000003434]
G	YGR203W	YCH1	289	-219.2	4	Phosphatase with sequence similarity to Cdc25p, Arr2p and Mih1p; member of the single-domain rhodanese homology superfamily; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000003435]
G	YGR204C-A	YGR204C-A	0	nf	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028640]
G	YGR204W	ADE3	3448	-1618.7	4	Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine [Source:SGD;Acc:S000003436]
G	YGR205W	TDA10	792	-185.5	4	ATP-binding protein of unknown function; crystal structure resembles that of E.coli pantothenate kinase and other small kinases; null mutant is sensitive to expression of the top1-T722A allele [Source:SGD;Acc:S000003437]
G	YGR206W	MVB12	108	-32.9	4	ESCRT-I subunit required to stabilize oligomers of the ESCRT-I core complex (Stp22p, Vps28p, Srn2p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; deletion mutant is sensitive to rapamycin and nystatin [Source:SGD;Acc:S000003438]
G	YGR207C	CIR1	1325	-250.1	4	Mitochondrial protein that interacts with frataxin (Yfh1p); putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-beta; may have a role in oxidative stress response [Source:SGD;Acc:S000003439]
G	YGR208W	SER2	1039	-205.3	4	Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source [Source:SGD;Acc:S000003440]
G	YGR209C	TRX2	2966	-310.4	4	Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance [Source:SGD;Acc:S000003441]
G	YGR210C	YGR210C	895	-313.5	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003442]
G	YGR211W	ZPR1	2007	-874.1	4	Essential protein with two zinc fingers, present in the nucleus of growing cells but relocates to the cytoplasm in starved cells via a process mediated by Cpr1p; binds to translation elongation factor eEF-1 (Tef1p) [Source:SGD;Acc:S000003443]
G	YGR212W	SLI1	26	-90.5	3	N-acetyltransferase, confers resistance to the sphingolipid biosynthesis inhibitor myriocin (ISP-1) by converting it into N-acetyl-myriocin, co-operates with Ypk1p in mediating resistance to myriocin [Source:SGD;Acc:S000003444]
G	YGR213C	RTA1	14	-4.2	2	Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein [Source:SGD;Acc:S000003445]
G	YGR214W	RPS0A	4294	-956.5	4	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Bp; required for maturation of 18S rRNA along with Rps0Bp; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal [Source:SGD;Acc:S000003446]
G	YGR215W	RSM27	428	-59.4	4	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000003447]
G	YGR216C	GPI1	48	-88.1	4	Membrane protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; human and mouse GPI1p are functional homologs [Source:SGD;Acc:S000003448]
G	YGR217W	CCH1	260	-336	4	Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together [Source:SGD;Acc:S000003449]
G	YGR218W	CRM1	2231	-1229	4	Major karyopherin, involved in export of proteins, RNAs, and ribosomal subunits from the nucleus; exportin [Source:SGD;Acc:S000003450]
G	YGR219W	YGR219W	3	-2.6	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRPL9/YGR220C [Source:SGD;Acc:S000003451]
G	YGR220C	MRPL9	331	-141.1	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000003452]
G	YGR221C	TOS2	39	-23.5	4	Protein involved in localization of Cdc24p to the site of bud growth; may act as a membrane anchor; localizes to the bud neck and bud tip; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000003453]
G	YGR222W	PET54	181	-179.1	4	Mitochondrial inner membrane protein; binds to the 5' UTR of the COX3 mRNA to activate its translation together with Pet122p and Pet494p; also binds to the COX1 Group I intron AI5 beta to facilitate exon ligation during splicing [Source:SGD;Acc:S000003454]
G	YGR223C	HSV2	191	-145.2	4	Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization [Source:SGD;Acc:S000003455]
G	YGR224W	AZR1	5	-2.2	2	Plasma membrane transporter of the major facilitator superfamily, involved in resistance to azole drugs such as ketoconazole and fluconazole [Source:SGD;Acc:S000003456]
G	YGR225W	AMA1	36	-17.6	2	Activator of meiotic anaphase promoting complex (APC/C); Cdc20p family member; required for initiation of spore wall assembly; required for Clb1p degradation during meiosis [Source:SGD;Acc:S000003457]
G	YGR226C	YGR226C	7	-2.2	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; overlaps significantly with a verified ORF, AMA1/YGR225W [Source:SGD;Acc:S000003458]
G	YGR227W	DIE2	72	-74	4	Dolichyl-phosphoglucose-dependent alpha-1,2 glucosyltransferase of the ER, functions in the pathway that synthesizes the dolichol-linked oligosaccharide precursor for N-linked protein glycosylation, has a role in regulation of ITR1 and INO1 [Source:SGD;Acc:S000003459]
G	YGR228W	YGR228W	3	-1.9	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SMI1/YGR229C [Source:SGD;Acc:S000003460]
G	YGR229C	SMI1	1216	-343	4	Protein involved in the regulation of cell wall synthesis; proposed to be involved in coordinating cell cycle progression with cell wall integrity [Source:SGD;Acc:S000003461]
G	YGR230W	BNS1	9	-4.9	2	Protein with some similarity to Spo12p; overexpression bypasses need for Spo12p, but not required for meiosis [Source:SGD;Acc:S000003462]
G	YGR231C	PHB2	1556	-277.9	4	Subunit of the prohibitin complex (Phb1p-Phb2p), a 1.2 MDa ring-shaped inner mitochondrial membrane chaperone that stabilizes newly synthesized proteins; determinant of replicative life span; involved in mitochondrial segregation [Source:SGD;Acc:S000003463]
G	YGR232W	NAS6	1057	-245.5	4	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); ortholog of human oncoprotein gankyrin, which interacts with the Rb tumor suppressor and CDK4/6 [Source:SGD;Acc:S000003464]
G	YGR233C	PHO81	1098	-586.6	4	Cyclin-dependent kinase (CDK) inhibitor, regulates Pho80p-Pho85p and Pcl7p-Pho85p cyclin-CDK complexes in response to phosphate levels; inhibitory activity for Pho80p-Pho85p requires myo-D-inositol heptakisphosphate (IP7) generated by Vip1p [Source:SGD;Acc:S000003465]
G	YGR234W	YHB1	3347	-1252.6	4	Nitric oxide oxidoreductase, flavohemoglobin involved in nitric oxide detoxification; plays a role in the oxidative and nitrosative stress responses [Source:SGD;Acc:S000003466]
G	YGR235C	MIC26	558	-229.4	4	Mitochondrial inner membrane protein; non-essential component of the mitochondrial inner membrane organizing system (MINOS, MitOS, or MICOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the mai  ce of crista junctions and inner membrane architecture [Source:SGD;Acc:S000003467]
G	YGR236C	SPG1	104	-143.7	4	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003468]
G	YGR237C	YGR237C	472	-356.3	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003469]
G	YGR238C	KEL2	326	-332.7	4	Protein that functions in a complex with Kel1p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate [Source:SGD;Acc:S000003470]
G	YGR239C	PEX21	20	-17.8	2	Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex18p [Source:SGD;Acc:S000003471]
G	YGR240C	PFK1	4559	-2711.3	4	Alpha subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes [Source:SGD;Acc:S000003472]
G	YGR240C-A	YGR240C-A	0	nf	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028551]
G	YGR241C	YAP1802	398	-287.9	4	Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1801p, member of the AP180 protein family [Source:SGD;Acc:S000003473]
G	YGR242W	YGR242W	5	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YAP1802/YGR241C [Source:SGD;Acc:S000003474]
G	YGR243W	MPC3	141	-52.2	4	Putative protein of unknown function; expression regulated by osmotic and alkaline stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003475]
G	YGR244C	LSC2	1611	-619.8	4	Beta subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate [Source:SGD;Acc:S000003476]
G	YGR245C	SDA1	1417	-332	4	Highly conserved nuclear protein required for actin cytoskeleton organization and passage through Start, plays a critical role in G1 events, binds Nap1p, also involved in 60S ribosome biogenesis [Source:SGD;Acc:S000003477]
G	YGR246C	BRF1	299	-220.8	4	TFIIIB B-related factor, one of three subunits of RNA polymerase III transcription initiation factor TFIIIB, binds TFIIIC and TBP and recruits RNA pol III to promoters, amino-terminal half is homologous to TFIIB [Source:SGD;Acc:S000003478]
G	YGR247W	CPD1	238	-142.7	4	Cyclic nucleotide phosphodiesterase, hydrolyzes ADP-ribose 1'', 2''-cyclic phosphate to ADP-ribose 1''-phosphate; may have a role in tRNA splicing; no detectable phenotype is conferred by null mutation or by overexpression [Source:SGD;Acc:S000003479]
G	YGR248W	SOL4	572	-249.8	4	6-phosphogluconolactonase with similarity to Sol3p [Source:SGD;Acc:S000003480]
G	YGR249W	MGA1	38	-12.2	2	Protein similar to heat shock transcription factor; multicopy suppressor of pseudohyphal growth defects of ammonium permease mutants [Source:SGD;Acc:S000003481]
G	YGR250C	YGR250C	1095	-565.1	4	Putative RNA binding protein; localizes to stress granules induced by glucose deprivation; interacts with Rbg1p in a two-hybrid [Source:SGD;Acc:S000003482]
G	YGR251W	NOP19	221	-69.1	4	Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for   oration of Utp25p into preribosomes [Source:SGD;Acc:S000003483]
G	YGR252W	GCN5	507	-479.5	4	Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase comple  ounding member of the Gcn5p-related N-acetyltransferase superfamily; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay [Source:SGD;Acc:S000003484]
G	YGR253C	PUP2	2288	-339	4	Alpha 5 subunit of the 20S proteasome involved in ubiquitin-dependent catabolism; human homolog is subunit zeta [Source:SGD;Acc:S000003485]
G	YGR254W	ENO1	7738	-2671.2	4	Enolase I, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is repressed in response to glucose [Source:SGD;Acc:S000003486]
G	YGR255C	COQ6	491	-238.4	4	Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast   utant and is implicated in steroid-resistant nephrotic syndrome (SRNS) [Source:SGD;Acc:S000003487]
G	YGR256W	GND2	2874	-660.9	4	6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone [Source:SGD;Acc:S000003488]
G	YGR257C	MTM1	115	-113.4	4	Mitochondrial protein of the mitochondrial carrier family, involved in activating mitochondrial Sod2p probably by facilitating insertion of an essential manganese cofactor [Source:SGD;Acc:S000003489]
G	YGR258C	RAD2	247	-201	4	Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein [Source:SGD;Acc:S000003490]
G	YGR259C	YGR259C	1	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF TNA1/YGR260W [Source:SGD;Acc:S000003491]
G	YGR260W	TNA1	259	-182.8	4	High affinity nicotinic acid plasma membrane permease, responsible for uptake of low levels of nicotinic acid; expression of the gene increases in the absence of extracellular nicotinic acid or para-aminobenzoate (PABA) [Source:SGD;Acc:S000003492]
G	YGR261C	APL6	1211	-572.4	4	Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools [Source:SGD;Acc:S000003493]
G	YGR262C	BUD32	281	-345.9	4	Protein kinase, component of the EKC/KEOPS complex with Kae1p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription [Source:SGD;Acc:S000003494]
G	YGR263C	SAY1	184	-193.4	4	Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum [Source:SGD;Acc:S000003495]
G	YGR264C	MES1	3009	-1128.7	4	Methionyl-tRNA synthetase, forms a complex with glutamyl-tRNA synthetase (Gus1p) and Arc1p, which increases the catalytic efficiency of both tRNA synthetases; also has a role in nuclear export of tRNAs [Source:SGD;Acc:S000003496]
G	YGR265W	YGR265W	5	-9.5	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase [Source:SGD;Acc:S000003497]
G	YGR266W	YGR266W	780	-489.4	4	Protein of unknown function, predicted to contain a single transmembrane domain; mutant has increased aneuploidy tolerance; localized to both the mitochondrial outer membrane and the plasma membrane [Source:SGD;Acc:S000003498]
G	YGR267C	FOL2	1409	-361.9	4	GTP-cyclohydrolase I, catalyzes the first step in the folic acid biosynthetic pathway [Source:SGD;Acc:S000003499]
G	YGR268C	HUA1	129	-107.1	4	Cytoplasmic protein containing a zinc finger domain with sequence similarity to that of Type I J-proteins; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly [Source:SGD;Acc:S000003500]
G	YGR269W	YGR269W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF HUA1/YGR268C [Source:SGD;Acc:S000003501]
G	YGR270C-A	YGR270C-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF YTA7/YGR270W [Source:SGD;Acc:S000028641]
G	YGR270W	YTA7	1138	-1171.9	4	Protein that localizes to chromatin and has a role in regulation of histone gene expression; has a bromodomain-like region that interacts with the N-terminal tail of histone H3, and an ATPase domain; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000003502]
G	YGR271C-A	EFG1	438	-152	4	Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus [Source:SGD;Acc:S000007608]
G	YGR271W	SLH1	640	-733.3	4	Putative RNA helicase related to Ski2p, involved in translation inhibition of non-poly(A) mRNAs; required for repressing propagation of dsRNA viruses [Source:SGD;Acc:S000003503]
G	YGR273C	YGR273C	2	-9	2	Putative protein of unknown function; expression downregulated by treatment with 8-methoxypsoralen plus UVA irradiation; YGR273C is not an essential gene [Source:SGD;Acc:S000003505]
G	YGR274C	TAF1	687	-1925.4	4	TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression [Source:SGD;Acc:S000003506]
G	YGR275W	RTT102	719	-114.5	4	Component of both the SWI/SNF and RSC chromatin remodeling complexes, suggested role in chromosome maintenance; possible weak regulator of Ty1 transposition [Source:SGD;Acc:S000003507]
G	YGR276C	RNH70	462	-204.3	4	3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts [Source:SGD;Acc:S000003508]
G	YGR277C	CAB4	734	-213	4	Probable pantetheine-phosphate adenylyltransferase (PPAT), which catalyzes the fourth step in the biosynthesis of coenzyme A from pantothenate; null mutant lethality is complemented by E. coli coaD (encoding PPAT); widely conserved [Source:SGD;Acc:S000003509]
G	YGR278W	CWC22	244	-221.4	4	Spliceosome-associated protein that is required for pre-mRNA splicing; necessary for Prp2p function at the first catalytic step of splicing; has similarity to S. pombe Cwf22p; CWC22 is an essential protein [Source:SGD;Acc:S000003510]
G	YGR279C	SCW4	1746	-311	4	Cell wall protein with similarity to glucanases; scw4 scw10 double mutants exhibit defects in mating [Source:SGD;Acc:S000003511]
G	YGR280C	PXR1	653	-131.6	4	Essential protein involved in rRNA and snoRNA maturation; competes with TLC1 RNA for binding to Est2p, suggesting a role in negative regulation of telomerase; human homolog inhibits telomerase; contains a G-patch RNA interacting domain [Source:SGD;Acc:S000003512]
G	YGR281W	YOR1	792	-562	4	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter mediates export of many different organic anions including oligomycin; similar to human cystic fibrosis transmembrane receptor (CFTR) [Source:SGD;Acc:S000003513]
G	YGR282C	BGL2	2568	-442.9	4	Endo-beta-1,3-glucanase, major protein of the cell wall, involved in cell wall maintenance [Source:SGD;Acc:S000003514]
G	YGR283C	YGR283C	393	-96.6	4	Putative S-adenosylmethionine-dependent methyltransferase; may interact with ribosomes, based on co-purification experiments; predicted to be involved in ribosome biogenesis; null mutant is resistant to fluconazole; GFP-fusion protein localizes to t  leolus [Source:SGD;Acc:S000003515]
G	YGR284C	ERV29	1333	-238.7	4	Protein localized to COPII-coated vesicles, involved in vesicle formation and incorporation of specific secretory cargo [Source:SGD;Acc:S000003516]
G	YGR285C	ZUO1	3309	-700.5	4	Ribosome-associated chaperone, functions in ribosome biogenesis and, in partnership with Ssz1p and SSb1/2, as a chaperone for nascent polypeptide chains; contains a DnaJ domain and functions as a J-protein partner for Ssb1p and Ssb2p [Source:SGD;Acc:S000003517]
G	YGR286C	BIO2	466	-209.4	4	Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant [Source:SGD;Acc:S000003518]
G	YGR287C	IMA1	178	-306.5	4	Major isomaltase (alpha-1,6-glucosidase) required for isomaltose utilization; has specificity for isomaltose, palatinose, and methyl-alpha-glucoside; member of the IMA isomaltase family [Source:SGD;Acc:S000003519]
G	YGR288W	MAL13	24	-51.8	4	MAL-activator protein, part of complex locus MAL1; nonfunctional in genomic reference strain S288C [Source:SGD;Acc:S000003520]
G	YGR289C	MAL11	8	-6.2	2	Inducible high-affinity maltose transporter (alpha-glucoside transporter); encoded in the MAL1 complex locus; broad substrate specificity that includes maltotriose; required for isomaltose utilization [Source:SGD;Acc:S000003521]
G	YGR290W	YGR290W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; putative HLH protein; partially overlaps the verified ORF MAL11/YGR289C (a high-affinity maltose transporter) [Source:SGD;Acc:S000003522]
G	YGR291C	YGR291C	6	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003523]
G	YGR292W	MAL12	208	-268.4	4	Maltase (alpha-D-glucosidase), inducible protein involved in maltose catabolism; encoded in the MAL1 complex locus; hydrolyzes the disaccharides maltose, turanose, maltotriose, and sucrose [Source:SGD;Acc:S000003524]
G	YGR293C	YGR293C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YGR294W [Source:SGD;Acc:S000003525]
G	YGR294W	PAU12	2	-1.1	1	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions [Source:SGD;Acc:S000003526]
G	YGR295C	COS6	186	-76.9	4	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000003527]
G	YGR296C-A	YGR296C-A	14	-25.7	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL07R [Source:SGD;Acc:S000028642]
G	YGR296C-B	YGR296C-B	1	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; contained completely within TEL07R [Source:SGD;Acc:S000028643]
G	YGR296W	YRF1-3	445	-454.8	4	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000003528]
H	YHL001W	RPL14B	3722	-345.8	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Ap and has similarity to rat L14 ribosomal protein [Source:SGD;Acc:S000000993]
H	YHL002C-A	YHL002C-A	2	-1.7	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028770]
H	YHL002W	HSE1	792	-302.4	4	Subunit of the endosomal Vps27p-Hse1p complex required for sorting of ubiquitinated membrane proteins into intralumenal vesicles prior to vacuolar degradation, as well as for recycling of Golgi proteins and formation of lumenal membranes [Source:SGD;Acc:S000000994]
H	YHL003C	LAG1	530	-151.8	4	Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p [Source:SGD;Acc:S000000995]
H	YHL004W	MRP4	707	-206.4	4	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000000996]
H	YHL005C	YHL005C	1	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YHL004W [Source:SGD;Acc:S000000997]
H	YHL006C	SHU1	32	-36.3	4	Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function [Source:SGD;Acc:S000000998]
H	YHL006W-A	YHL006W-A	3	-1.2	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028771]
H	YHL007C	STE20	1531	-750.4	4	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family; involved in pheromone response, pseudohyphal/invasive growth, vacuole inheritance, down-regulation of sterol uptake; GBB motif binds Ste4p [Source:SGD;Acc:S000000999]
H	YHL008C	YHL008C	199	-52.5	4	Putative protein of unknown function, may be involved in the uptake of chloride ions; does not appear to be involved in monocarboxylic acid transport; green fluorescent protein (GFP)-fusion protein localizes to the vacuole [Source:SGD;Acc:S000001000]
H	YHL009C	YAP3	344	-112.8	4	Basic leucine zipper (bZIP) transcription factor [Source:SGD;Acc:S000001001]
H	YHL009W-A	YHL009W-A	13	-11.4	2	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007371]
H	YHL009W-B	YHL009W-B	40	-27.7	2	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007372]
H	YHL010C	ETP1	232	-266.3	4	Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences [Source:SGD;Acc:S000001002]
H	YHL011C	PRS3	1920	-483.7	4	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes [Source:SGD;Acc:S000001003]
H	YHL012W	YHL012W	22	-18.1	2	Putative protein of unknown function, has some homology to Ugp1p, which encodes UDP-glucose pyrophosphorylase [Source:SGD;Acc:S000001004]
H	YHL013C	OTU2	665	-246.5	4	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; member of the ovarian tumor-like (OTU) superfamily of predicted cysteine proteases; shows cytoplasmic localization [Source:SGD;Acc:S000001005]
H	YHL014C	YLF2	225	-259.2	4	Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001006]
H	YHL015W	RPS20	4288	-348.5	4	Protein component of the small (40S) ribosomal subunit; overproduction suppresses mutations affecting RNA polymerase III-dependent transcription; has similarity to E. coli S10 and rat S20 ribosomal proteins [Source:SGD;Acc:S000001007]
H	YHL015W-A	YHL015W-A	4	-2.4	2	Putative protein of unknown function [Source:SGD;Acc:S000028828]
H	YHL016C	DUR3	21	-36.4	4	Plasma membrane transporter for both urea and polyamines, expression is highly sensitive to nitrogen catabolite repression and induced by allophanate, the last intermediate of the allantoin degradative pathway [Source:SGD;Acc:S000001008]
H	YHL017W	YHL017W	140	-84	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein co-localizes with clathrin-coated vesicles [Source:SGD;Acc:S000001009]
H	YHL018W	YHL018W	83	-59.3	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000001010]
H	YHL019C	APM2	126	-103.6	4	Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport [Source:SGD;Acc:S000001011]
H	YHL019W-A	YHL019W-A	3	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene APM2/YHL019C [Source:SGD;Acc:S000028772]
H	YHL020C	OPI1	420	-163.1	4	Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance [Source:SGD;Acc:S000001012]
H	YHL021C	AIM17	1344	-817.8	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000001013]
H	YHL022C	SPO11	15	-2	1	Meiosis-specific protein that initiates meiotic recombination by catalyzing the formation of double-strand breaks in DNA via a transesterification reaction; required for homologous chromosome pairing and synaptonemal complex formation [Source:SGD;Acc:S000001014]
H	YHL023C	NPR3	393	-288.7	4	Subunit of SEA (Seh1-associated), Npr2/3, and Iml1p complexes; Npr2/3 complex mediates downregulation of TORC1 activity upon amino acid limitation; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex  p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy; required for Npr2p phosphorylation and Iml1p-Npr2p interaction; null mutant shows delayed meiotic DNA replication and double-strand break repair [Source:SGD;Acc:S000001015]
H	YHL024W	RIM4	218	-215.5	4	Putative RNA-binding protein required for the expression of early and middle sporulation genes [Source:SGD;Acc:S000001016]
H	YHL025W	SNF6	250	-130.5	4	Subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; functions interdependently in transcriptional activation with Snf2p and Snf5p [Source:SGD;Acc:S000001017]
H	YHL026C	YHL026C	8	-11.2	2	Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; YHL026C is not an essential gene; in 2005 the start site was moved 141 nt upstream (see Locus History) [Source:SGD;Acc:S000001018]
H	YHL027W	RIM101	143	-79.6	4	Transcriptional repressor involved in response to pH and in cell wall construction; required for alkaline pH-stimulated haploid invasive growth and sporulation; activated by proteolytic processing; similar to A. nidulans PacC [Source:SGD;Acc:S000001019]
H	YHL028W	WSC4	36	-16.9	4	ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3 [Source:SGD;Acc:S000001020]
H	YHL029C	OCA5	211	-117	4	Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts [Source:SGD;Acc:S000001021]
H	YHL030W	ECM29	1349	-1272.2	4	Scaffold protein that assists in association of the proteasome core particle with the regulatory particle; degraded by the mature proteasome after assembly; contains HEAT-like repeats [Source:SGD;Acc:S000001022]
H	YHL030W-A	YHL030W-A	1	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene GOS1/YHL031C [Source:SGD;Acc:S000028773]
H	YHL031C	GOS1	808	-295	4	v-SNARE protein involved in Golgi transport, homolog of the mammalian protein GOS-28/GS28 [Source:SGD;Acc:S000001023]
H	YHL032C	GUT1	384	-1465.1	4	Glycerol kinase, converts glycerol to glycerol-3-phosphate; glucose repression of expression is mediated by Adr1p and Ino2p-Ino4p; derepression of expression on non-fermentable carbon sources is mediated by Opi1p and Rsf1p [Source:SGD;Acc:S000001024]
H	YHL033C	RPL8A	4756	-1196.8	4	Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Bp and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits [Source:SGD;Acc:S000001025]
H	YHL034C	SBP1	2684	-855.6	4	Putative RNA binding protein; involved in translational repression and found in cytoplasmic P bodies; found associated with small nucleolar RNAs snR10 and snR11 [Source:SGD;Acc:S000001026]
H	YHL034W-A	YHL034W-A	53	-2.3	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028774]
H	YHL035C	VMR1	534	-43.7	4	Vacuolar membrane protein involved in multiple drug resistance and metal sensitivity; ATP-binding cassette (ABC) family member involved in drug transport; potential Cdc28p substrate; induced under respiratory conditions [Source:SGD;Acc:S000001027]
H	YHL036W	MUP3	16	-10.8	2	Low affinity methionine permease, similar to Mup1p [Source:SGD;Acc:S000001028]
H	YHL037C	YHL037C	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001029]
H	YHL038C	CBP2	246	-276.2	4	Mitochondrial protein required for splicing of the group I intron aI5 of the COB pre-mRNA, binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene [Source:SGD;Acc:S000001030]
H	YHL039W	EFM1	797	-436.5	4	Probable lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001031]
H	YHL040C	ARN1	40	-93.4	4	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to ferrirubin, ferrirhodin, and related siderophores [Source:SGD;Acc:S000001032]
H	YHL041W	YHL041W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000001033]
H	YHL042W	YHL042W	14	-3.7	2	Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000001034]
H	YHL043W	ECM34	4	-2.8	2	Putative protein of unknown function; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000001035]
H	YHL044W	YHL044W	5	-3.3	2	Putative integral membrane protein, member of DUP240 gene family; green fluorescent protein (GFP)-fusion protein localizes to the plasma membrane in a punctate pattern [Source:SGD;Acc:S000001036]
H	YHL045W	YHL045W	0	nf	1	Putative protein of unknown function; not an essential gene [Source:SGD;Acc:S000001037]
H	YHL046C	PAU13	1	-0.1	1	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression is induced after ethanol shock [Source:SGD;Acc:S000001038]
H	YHL046W-A	YHL046W-A	7	-2.5	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028775]
H	YHL047C	ARN2	24	-63.4	4	Transporter, member of the ARN family of transporters that specifically recognize siderophore-iron chelates; responsible for uptake of iron bound to the siderophore triacetylfusarinine C [Source:SGD;Acc:S000001039]
H	YHL048C-A	YHL048C-A	1	-1.2	1	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028829]
H	YHL048W	COS8	167	-94	4	Nuclear membrane protein, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins; regulation suggests a potential role in the unfolded protein response [Source:SGD;Acc:S000001040]
H	YHL049C	YHL049C	139	-78.2	4	Putative protein of unknown function [Source:SGD;Acc:S000001041]
H	YHL050C	YHL050C	216	-172.5	4	Putative protein of unknown function, potential Cdc28p substrate [Source:SGD;Acc:S000001042]
H	YHL050W-A	YHL050W-A	43	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028644]
H	YHR001W	OSH7	1181	-421.6	4	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability [Source:SGD;Acc:S000001043]
H	YHR001W-A	QCR10	399	-133.3	4	Subunit of the ubiqunol-cytochrome c oxidoreductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p and comprises part of the mitochondrial respiratory chain [Source:SGD;Acc:S000003529]
H	YHR002W	LEU5	37	-103.1	4	Mitochondrial carrier protein involved in the accumulation of CoA in the mitochondrial matrix; homolog of human Graves disease protein; does not encode an isozyme of Leu4p, as first hypothesized [Source:SGD;Acc:S000001044]
H	YHR003C	TCD1	522	-228.8	4	Protein of unknown function, localized to the mitochondrial outer membrane [Source:SGD;Acc:S000001045]
H	YHR004C	NEM1	64	-79.5	4	Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard [Source:SGD;Acc:S000001046]
H	YHR005C	GPA1	738	-385.3	4	GTP-binding alpha subunit of the heterotrimeric G protein that couples to pheromone receptors; negatively regulates the mating pathway by sequestering G(beta)gamma and by triggering an adaptive response; activates Vps34p at the endosome [Source:SGD;Acc:S000001047]
H	YHR005C-A	TIM10	1173	-471.1	4	Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner membrane [Source:SGD;Acc:S000003530]
H	YHR006W	STP2	112	-82.2	4	Transcription factor, activated by proteolytic processing in response to signals from the SPS sensor system for external amino acids; activates transcription of amino acid permease genes [Source:SGD;Acc:S000001048]
H	YHR007C	ERG11	2009	-542.4	4	Lanosterol 14-alpha-demethylase; catalyzes the C-14 demethylation of lanosterol to form 4,4''-dimethyl cholesta-8,14,24-triene-3-beta-ol in the ergosterol biosynthesis pathway; member of the cytochrome P450 family; associated and coordinately regula  th the P450 reductase Ncp1p [Source:SGD;Acc:S000001049]
H	YHR007C-A	YHR007C-A	0	nf	1	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028830]
H	YHR008C	SOD2	1901	-668	4	Mitochondrial manganese superoxide dismutase, protects cells against oxygen toxicity; phosphorylated [Source:SGD;Acc:S000001050]
H	YHR009C	TDA3	1111	-363.8	4	Putative oxidoreductase involved in late endosome to Golgi transport; physical and genetical interactions with Btn2p; null mutant is viable, has extended S phase, and sensitive to expression of top1-T722A allele; similar to human FOXRED1 [Source:SGD;Acc:S000001051]
H	YHR010W	RPL27A	4196	-574.2	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl27Bp and has similarity to rat L27 ribosomal protein [Source:SGD;Acc:S000001052]
H	YHR011W	DIA4	206	-170.1	4	Probable mitochondrial seryl-tRNA synthetase, mutant displays increased invasive and pseudohyphal growth [Source:SGD;Acc:S000001053]
H	YHR012W	VPS29	842	-171.7	4	Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval [Source:SGD;Acc:S000001054]
H	YHR013C	ARD1	1098	-212.6	4	Subunit of N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); acetylates many proteins and thus affects telomeric silencing, cell cycle, heat-shock resistance, mating, and sporulation; human Ard1p levels are elevated in cancer cells [Source:SGD;Acc:S000001055]
H	YHR014W	SPO13	6	-46.8	4	Meiosis-specific protein, involved in maintaining sister chromatid cohesion during meiosis I as well as promoting proper attachment of kinetochores to the spindle during meiosis I and meiosis II [Source:SGD;Acc:S000001056]
H	YHR015W	MIP6	28	-14.5	2	Putative RNA-binding protein, interacts with Mex67p, which is a component of the nuclear pore involved in nuclear mRNA export [Source:SGD;Acc:S000001057]
H	YHR016C	YSC84	1347	-306.8	4	Actin-binding protein involved in bundling of actin filaments and endocytosis of actin cortical patches; activity stimulated by Las17p; contains SH3 domain similar to Rvs167p [Source:SGD;Acc:S000001058]
H	YHR017W	YSC83	198	-160.9	4	Non-essential mitochondrial protein of unknown function; mRNA induced during meiosis, peaking between mid to late prophase of meiosis I; similar to S. douglasii YSD83 [Source:SGD;Acc:S000001059]
H	YHR018C	ARG4	1981	-815.4	4	Argininosuccinate lyase, catalyzes the final step in the arginine biosynthesis pathway [Source:SGD;Acc:S000001060]
H	YHR019C	DED81	3244	-1210.1	4	Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA [Source:SGD;Acc:S000001061]
H	YHR020W	YHR020W	3448	-1032.2	4	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; has similarity to proline-tRNA ligase; YHR020W is an essential gene [Source:SGD;Acc:S000001062]
H	YHR021C	RPS27B	2975	-268.6	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Ap and has similarity to rat S27 ribosomal protein [Source:SGD;Acc:S000001063]
H	YHR021W-A	ECM12	1	-1.1	1	Putative protein of unknown function; may contribute to cell wall biosynthesis, mutants display zymolyase hypersensitivity [Source:SGD;Acc:S000003531]
H	YHR022C	YHR022C	12	-34.8	2	Putative protein of unknown function; YHR022C is not an essential gene [Source:SGD;Acc:S000001064]
H	YHR022C-A	YHR022C-A	0	nf	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028645]
H	YHR023W	MYO1	717	-880.7	4	Type II myosin heavy chain, required for wild-type cytokinesis and cell separation; localizes to the actomyosin ring; binds to myosin light chains Mlc1p and Mlc2p through its IQ1 and IQ2 motifs respectively [Source:SGD;Acc:S000001065]
H	YHR024C	MAS2	1020	-319.7	4	Larger subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins [Source:SGD;Acc:S000001066]
H	YHR025W	THR1	2217	-1297.9	4	Homoserine kinase, conserved protein required for threonine biosynthesis; expression is regulated by the GCN4-mediated general amino acid control pathway [Source:SGD;Acc:S000001067]
H	YHR026W	VMA16	85	-51.6	4	Subunit c'' of the vacuolar ATPase, which functions in acidification of the vacuole; one of three proteolipid subunits of the V0 domain [Source:SGD;Acc:S000001068]
H	YHR027C	RPN1	2844	-1784.1	4	Non-ATPase base subunit of the 19S regulatory particle of the 26S proteasome; may participate in the recognition of several ligands of the proteasome; contains a leucine-rich repeat (LRR) domain, a site for protein-protein interactions [Source:SGD;Acc:S000001069]
H	YHR028C	DAP2	635	-283.9	4	Dipeptidyl aminopeptidase, synthesized as a glycosylated precursor; localizes to the vacuolar membrane; similar to Ste13p [Source:SGD;Acc:S000001070]
H	YHR028W-A	YHR028W-A	4	-1.4	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028776]
H	YHR029C	YHI9	975	-233.1	4	Protein of unknown function; null mutant is defective in unfolded protein response; possibly involved in a membrane regulation metabolic pathway; member of the PhzF superfamily, though most likely not involved in phenazine production [Source:SGD;Acc:S000001071]
H	YHR030C	SLT2	1090	-1492.7	4	Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the ph  re assembly site (PAS); regulated by the PKC1-mediated signaling pathway [Source:SGD;Acc:S000001072]
H	YHR031C	RRM3	135	-133.2	4	DNA helicase involved in rDNA replication and Ty1 transposition; relieves replication fork pauses at telomeric regions; structurally and functionally related to Pif1p [Source:SGD;Acc:S000001073]
H	YHR032C-A	YHR032C-A	2	-2.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032W-A [Source:SGD;Acc:S000028646]
H	YHR032W	ERC1	27	-19.3	4	Member of the multi-drug and toxin extrusion (MATE) family of the multidrug/oligosaccharidyl-lipid/polysaccharide (MOP) exporter superfamily; overproduction confers ethionine resistance and accumulation of S-adenosylmethionine [Source:SGD;Acc:S000001074]
H	YHR032W-A	YHR032W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YHR032C-A [Source:SGD;Acc:S000028831]
H	YHR033W	YHR033W	187	-165.5	4	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm [Source:SGD;Acc:S000001075]
H	YHR034C	PIH1	523	-187.6	4	Protein of unresolved function; may function in protein folding and/or rRNA processing, interacts with a chaperone (Hsp82p), two chromatin remodeling factors (Rvb1p, Rvb2p) and two rRNA processing factors (Rrp43p, Nop58p) [Source:SGD;Acc:S000001076]
H	YHR035W	NEL1	23	-20.7	2	Putative protein of unknown function; not an essential gene [Source:SGD;Acc:S000001077]
H	YHR036W	BRL1	187	-150.2	4	Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export [Source:SGD;Acc:S000001078]
H	YHR037W	PUT2	1373	-499.6	4	Delta-1-pyrroline-5-carboxylate dehydrogenase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; deficiency of the human homolog causes HPII, an autosomal recessive inborn error of metabolism [Source:SGD;Acc:S000001079]
H	YHR038W	RRF1	314	-97.3	4	Mitochondrial ribosome recycling factor, essential for mitochondrial protein synthesis and for the maintenance of the respiratory function of mitochondria [Source:SGD;Acc:S000001080]
H	YHR039C	MSC7	1446	-657.3	4	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; msc7 mutants are defective in directing meiotic recombination events to homologous chromatids [Source:SGD;Acc:S000001081]
H	YHR039C-A	VMA10	1853	-250.7	4	Subunit G of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; involved in vacuolar acidification [Source:SGD;Acc:S000002100]
H	YHR040W	BCD1	396	-141.1	4	Essential protein required for the accumulation of box C/D snoRNA [Source:SGD;Acc:S000001082]
H	YHR041C	SRB2	345	-133.2	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; general transcription factor involved in telomere maintenance [Source:SGD;Acc:S000001083]
H	YHR042W	NCP1	2470	-934.4	4	NADP-cytochrome P450 reductase; involved in ergosterol biosynthesis; associated and coordinately regulated with Erg11p [Source:SGD;Acc:S000001084]
H	YHR043C	DOG2	715	-143.8	4	2-deoxyglucose-6-phosphate phosphatase, member of a family of low molecular weight phosphatases, similar to Dog1p, induced by oxidative and osmotic stress, confers 2-deoxyglucose resistance when overexpressed [Source:SGD;Acc:S000001085]
H	YHR044C	DOG1	624	-89.8	4	2-deoxyglucose-6-phosphate phosphatase, similar to Dog2p, member of a family of low molecular weight phosphatases; confers 2-deoxyglucose resistance when overexpressed, in vivo substrate has not yet been identified [Source:SGD;Acc:S000001086]
H	YHR045W	YHR045W	474	-311.7	4	Putative protein of unknown function; possible role in iron metabolism and/or amino acid and carbohydrate metabolism; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum [Source:SGD;Acc:S000001087]
H	YHR046C	INM1	508	-126.6	4	Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate [Source:SGD;Acc:S000001088]
H	YHR047C	AAP1	1788	-920.4	4	Arginine/alanine aminopeptidase, overproduction stimulates glycogen accumulation [Source:SGD;Acc:S000001089]
H	YHR048W	YHK8	27	-25.4	2	Presumed antiporter of the DHA1 family of multidrug resistance transporters; contains 12 predicted transmembrane spans; expression of gene is up-regulated in cells exhibiting reduced susceptibility to azoles [Source:SGD;Acc:S000001090]
H	YHR049C-A	YHR049C-A	2	-2.1	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003532]
H	YHR049W	FSH1	1748	-423.9	4	Putative serine hydrolase that localizes to both the nucleus and cytoplasm; sequence is similar to S. cerevisiae Fsh2p and Fsh3p and the human candidate tumor suppressor OVCA2 [Source:SGD;Acc:S000001091]
H	YHR050W	SMF2	78	-136	4	Divalent metal ion transporter involved in manganese homeostasis; has broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins [Source:SGD;Acc:S000001092]
H	YHR050W-A	YHR050W-A	3	-1.5	1	Protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028832]
H	YHR051W	COX6	1278	-288.4	4	Subunit VI of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; expression is regulated by oxygen levels [Source:SGD;Acc:S000001093]
H	YHR052W	CIC1	1702	-298.2	4	Essential protein that interacts with proteasome components and has a potential role in proteasome substrate specificity; also copurifies with 66S pre-ribosomal particles [Source:SGD;Acc:S000001094]
H	YHR052W-A	YHR052W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-1 [Source:SGD;Acc:S000028647]
H	YHR053C	CUP1-1	654	-137.6	4	Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C [Source:SGD;Acc:S000001095]
H	YHR054C	YHR054C	386	-121	4	Putative protein of unknown function [Source:SGD;Acc:S000001096]
H	YHR054W-A	YHR054W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CUP1-2 [Source:SGD;Acc:S000028648]
H	YHR055C	YHR055C	654	-137.6	4	Metallothionein, binds copper and mediates resistance to high concentrations of copper and cadmium; locus is variably amplified in different strains, with two copies, CUP1-1 and CUP1-2, in the genomic sequence reference strain S288C [Source:SGD;Acc:S000001097]
H	YHR056C	RSC30	823	-247.1	4	Component of the RSC chromatin remodeling complex; non-essential gene required for regulation of ribosomal protein genes and the cell wall/stress response; highly similar to Rsc3p; null mutants are osmosensitive [Source:SGD;Acc:S000001098]
H	YHR056W-A	YHR056W-A	10	-5.6	2	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028777]
H	YHR057C	CPR2	209	-80.5	4	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; has a potential role in the secretory pathway [Source:SGD;Acc:S000001099]
H	YHR058C	MED6	494	-266.9	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation [Source:SGD;Acc:S000001100]
H	YHR059W	FYV4	108	-50.6	4	Protein of unknown function, required for survival upon exposure to K1 killer toxin [Source:SGD;Acc:S000001101]
H	YHR060W	VMA22	529	-81.8	4	Peripheral membrane protein that is required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the yeast endoplasmic reticulum (ER) [Source:SGD;Acc:S000001102]
H	YHR061C	GIC1	32	-38.9	4	Protein of unknown function involved in initiation of budding and cellular polarization, interacts with Cdc42p via the Cdc42/Rac-interactive binding (CRIB) domain [Source:SGD;Acc:S000001103]
H	YHR062C	RPP1	396	-207.5	4	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs [Source:SGD;Acc:S000001104]
H	YHR063C	PAN5	1614	-408.7	4	2-dehydropantoate 2-reductase, part of the pantothenic acid pathway, structurally homologous to E. coli panE [Source:SGD;Acc:S000001105]
H	YHR063W-A	YHR063W-A	9	-11.1	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028778]
H	YHR064C	SSZ1	3962	-959.1	4	Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP [Source:SGD;Acc:S000001106]
H	YHR065C	RRP3	1262	-377.4	4	Protein involved in rRNA processing; required for maturation of the 35S primary transcript of pre-rRNA and for cleavage leading to mature 18S rRNA; homologous to eIF-4a, which is a DEAD box RNA-dependent ATPase with helicase activity [Source:SGD;Acc:S000001107]
H	YHR066W	SSF1	1088	-194.6	4	Constituent of 66S pre-ribosomal particles, required for ribosomal large subunit maturation; functionally redundant with Ssf2p; member of the Brix family [Source:SGD;Acc:S000001108]
H	YHR067W	HTD2	61	-135.5	4	Mitochondrial 3-hydroxyacyl-thioester dehydratase involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology [Source:SGD;Acc:S000001109]
H	YHR068W	DYS1	2590	-766.2	4	Deoxyhypusine synthase, catalyzes formation of deoxyhypusine, the first step in hypusine biosynthesis; triggers posttranslational hypusination of translation elongation factor eIF-5A and regulates its intracellular levels; tetrameric [Source:SGD;Acc:S000001110]
H	YHR069C	RRP4	978	-520	4	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain RNA binding domains; has similarity to human hRrp4p (EXOSC2) [Source:SGD;Acc:S000001111]
H	YHR069C-A	YHR069C-A	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028779]
H	YHR070C-A	YHR070C-A	8	-2.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene TRM5/YHR070W [Source:SGD;Acc:S000028780]
H	YHR070W	TRM5	784	-331.3	4	tRNA(m(1)G37)methyltransferase, methylates a tRNA base adjacent to the anticodon that has a role in prevention of frameshifting; highly conserved across Archaea, Bacteria, and Eukarya [Source:SGD;Acc:S000001112]
H	YHR071C-A	YHR071C-A	3	-2.5	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ERG7/YHR072W [Source:SGD;Acc:S000028781]
H	YHR071W	PCL5	4	-118.8	2	Cyclin, interacts with and phosphorylated by Pho85p cyclin-dependent kinase (Cdk), induced by Gcn4p at level of transcription, specifically required for Gcn4p degradation, may be sensor of cellular protein biosynthetic capacity [Source:SGD;Acc:S000001113]
H	YHR072W	ERG7	572	-578.9	4	Lanosterol synthase, an essential enzyme that catalyzes the cyclization of squalene 2,3-epoxide, a step in ergosterol biosynthesis [Source:SGD;Acc:S000001114]
H	YHR072W-A	NOP10	1021	-92	4	Constituent of small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs, which are required for pseudouridylation and processing of pre-18S rRNA [Source:SGD;Acc:S000007455]
H	YHR073C-B	YHR073C-B	3	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028833]
H	YHR073W	OSH3	912	-626	4	Member of an oxysterol-binding protein family with seven members in S. cerevisiae; family members have overlapping, redundant functions in sterol metabolism and collectively perform a function essential for viability [Source:SGD;Acc:S000001115]
H	YHR073W-A	YHR073W-A	7	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF YHR073W; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028834]
H	YHR074W	QNS1	1526	-662.3	4	Glutamine-dependent NAD(+) synthetase, essential for the formation of NAD(+) from nicotinic acid adenine dinucleotide [Source:SGD;Acc:S000001116]
H	YHR075C	PPE1	126	-145.8	4	Protein with carboxyl methyl esterase activity that may have a role in demethylation of the phosphoprotein phosphatase catalytic subunit; also identified as a small subunit mitochondrial ribosomal protein [Source:SGD;Acc:S000001117]
H	YHR076W	PTC7	681	-1201.9	4	Type 2C protein phosphatase (PP2C); alternatively spliced to create two mRNA isoforms; protein from spliced form localizes to the mitochondria while the one from the unspliced form is localized to the nuclear envelope [Source:SGD;Acc:S000001118]
H	YHR077C	NMD2	581	-446.1	4	Protein involved in the nonsense-mediated mRNA decay (NMD) pathway; interacts with Nam7p and Upf3p; involved in telomere maintenance [Source:SGD;Acc:S000001119]
H	YHR078W	YHR078W	57	-119.4	4	High osmolarity-regulated gene of unknown function [Source:SGD;Acc:S000001120]
H	YHR079C	IRE1	188	-930.7	4	Serine-threonine kinase and endoribonuclease; transmembrane protein that mediates the unfolded protein response (UPR) by regulating Hac1p synthesis through HAC1 mRNA splicing; Kar2p binds inactive Ire1p and releases from it upon ER stress [Source:SGD;Acc:S000001121]
H	YHR079C-A	SAE3	1	0	1	Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Mei5p; proposed to be an assembly factor for Dmc1p [Source:SGD;Acc:S000001957]
H	YHR080C	YHR080C	230	-392.5	4	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001122]
H	YHR081W	LRP1	526	-141.4	4	Nuclear exosome-associated nucleic acid binding protein; involved in RNA processing, surveillance, degradation, tethering, and export; homolog of mammalian nuclear matrix protein C1D involved in regulation of DNA repair and recombination [Source:SGD;Acc:S000001123]
H	YHR082C	KSP1	903	-2553.1	4	Ser/thr protein kinase; nuclear translocation required for haploid filamentous growth; regulates filamentous growth induced nuclear translocation of Bcy1p, Fus3p, and Sks1p; overproduction causes allele-specific suppression of prp20-10 [Source:SGD;Acc:S000001124]
H	YHR083W	SAM35	299	-232.5	4	Essential component of the sorting and assembly machinery (SAM complex or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their insertion into the outer membrane [Source:SGD;Acc:S000001125]
H	YHR084W	STE12	716	-1516.7	4	Transcription factor that is activated by a MAP kinase signaling cascade, activates genes involved in mating or pseudohyphal/invasive growth pathways; cooperates with Tec1p transcription factor to regulate genes specific for invasive growth [Source:SGD;Acc:S000001126]
H	YHR085W	IPI1	359	-113.5	4	Essential component of the Rix1 complex (with Rix1p and Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles [Source:SGD;Acc:S000001127]
H	YHR086W	NAM8	374	-287.1	4	RNA binding protein, component of the U1 snRNP protein; mutants are defective in meiotic recombination and in formation of viable spores, involved in the formation of DSBs through meiosis-specific splicing of REC107 pre-mRNA; Nam8p regulon embraces   iotic pre-mRNAs of REC107, HFM1, AMA1 SPO22 and PCH2; the putative RNA binding domains RRM2 and RRM3 are required for Nam8p meiotic function [Source:SGD;Acc:S000001128]
H	YHR086W-A	YHR086W-A	1	-1.1	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028552]
H	YHR087W	RTC3	1155	-168.8	4	Protein of unknown function involved in RNA metabolism; has structural similarity to SBDS, the human protein mutated in Shwachman-Diamond Syndrome (the yeast SBDS ortholog = SDO1); null mutation suppresses cdc13-1 temperature sensitivity [Source:SGD;Acc:S000001129]
H	YHR088W	RPF1	942	-226.4	4	Nucleolar protein involved in the assembly and export of the large ribosomal subunit; constituent of 66S pre-ribosomal particles; contains a sigma(70)-like motif, which is thought to bind RNA [Source:SGD;Acc:S000001130]
H	YHR089C	GAR1	2166	-259.9	4	Protein component of the H/ACA snoRNP pseudouridylase complex, involved in the modification and cleavage of the 18S pre-rRNA [Source:SGD;Acc:S000001131]
H	YHR090C	YNG2	268	-84.5	4	Subunit of NuA4, an essential histone acetyltransferase complex; positions Piccolo NuA4 for efficient acetylation of histone H4 or histone H2A; has similarity to the human tumor suppressor ING1 and its isoforms ING4 and ING5 [Source:SGD;Acc:S000001132]
H	YHR091C	MSR1	959	-312.7	4	Mitochondrial arginyl-tRNA synthetase [Source:SGD;Acc:S000001133]
H	YHR092C	HXT4	583	-327.8	4	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose [Source:SGD;Acc:S000001134]
H	YHR093W	AHT1	4	-4.8	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; multicopy suppressor of glucose transport defects, likely due to the presence of an HXT4 regulatory element in the region [Source:SGD;Acc:S000001135]
H	YHR094C	HXT1	1332	-281.4	4	Low-affinity glucose transporter of the major facilitator superfamily, expression is induced by Hxk2p in the presence of glucose and repressed by Rgt1p when glucose is limiting [Source:SGD;Acc:S000001136]
H	YHR095W	YHR095W	55	-3.2	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001137]
H	YHR096C	HXT5	848	-414.1	4	Hexose transporter with moderate affinity for glucose, induced in the presence of non-fermentable carbon sources, induced by a decrease in growth rate, contains an extended N-terminal domain relative to other HXTs [Source:SGD;Acc:S000001138]
H	YHR097C	YHR097C	1256	-306.6	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus [Source:SGD;Acc:S000001139]
H	YHR098C	SFB3	1583	-682.1	4	Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p [Source:SGD;Acc:S000001140]
H	YHR099W	TRA1	1332	-4475.4	4	Subunit of SAGA and NuA4 histone acetyltransferase complexes; interacts with acidic activators (e.g., Gal4p) which leads to transcription activation; similar to human TRRAP, which is a cofactor for c-Myc mediated oncogenic transformation [Source:SGD;Acc:S000001141]
H	YHR100C	GEP4	142	-72.8	4	Mitochondrial phosphatidylglycerophosphatase (PGP phosphatase), dephosphorylates phosphatidylglycerolphosphate to generate phosphatidylglycerol, an essential step during cardiolipin biosynthesis; null mutant is sensitive to tunicamycin, DTT [Source:SGD;Acc:S000001142]
H	YHR101C	BIG1	155	-51.5	4	Integral membrane protein of the endoplasmic reticulum, required for normal content of cell wall beta-1,6-glucan [Source:SGD;Acc:S000001143]
H	YHR102W	KIC1	559	-2387.8	4	Protein kinase of the PAK/Ste20 family, required for cell integrity; physically interacts with Cdc31p (centrin), which is a component of the spindle pole body; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000001144]
H	YHR103W	SBE22	576	-300.5	4	Protein involved in the transport of cell wall components from the Golgi to the cell surface; similar in structure and functionally redundant with Sbe2p; involved in bud growth [Source:SGD;Acc:S000001145]
H	YHR104W	GRE3	2027	-553.3	4	Aldose reductase involved in methylglyoxal, d-xylose, arabinose, and galactose metabolism; stress induced (osmotic, ionic, oxidative, heat shock, starvation and heavy metals); regulated by the HOG pathway [Source:SGD;Acc:S000001146]
H	YHR105W	YPT35	76	-83.8	4	Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport [Source:SGD;Acc:S000001147]
H	YHR106W	TRR2	1350	-249.1	4	Mitochondrial thioredoxin reductase involved in protection against oxidative stress, required with Glr1p to maintain the redox state of Trx3p; contains active-site motif (CAVC) present in prokaryotic orthologs; binds NADPH and FAD [Source:SGD;Acc:S000001148]
H	YHR107C	CDC12	2353	-1201.4	4	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds f  ruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells; [Source:SGD;Acc:S000001149]
H	YHR108W	GGA2	1815	-483	4	Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin [Source:SGD;Acc:S000001150]
H	YHR109W	CTM1	109	-134.7	4	Cytochrome c lysine methyltransferase, trimethylates residue 72 of apo-cytochrome c (Cyc1p) in the cytosol; not required for normal respiratory growth [Source:SGD;Acc:S000001151]
H	YHR110W	ERP5	135	-67.9	4	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport [Source:SGD;Acc:S000001152]
H	YHR111W	UBA4	654	-239.5	4	Protein that activates Urm1p before its conjugation to proteins (urmylation); also acts in thiolation of the wobble base of cytoplasmic tRNAs by adenylating and then thiolating Urm1p; receives sulfur from Tum1p [Source:SGD;Acc:S000001153]
H	YHR112C	YHR112C	615	-377.9	4	Protein of unknown function; localizes to the cytoplasm and nucleus; overexpression affects protein trafficking through the endocytic pathway [Source:SGD;Acc:S000001154]
H	YHR113W	APE4	956	-565.2	4	Cytoplasmic aspartyl aminopeptidase that may also function in the vacuole; CVT pathway cargo protein; cleaves unblocked N-terminal acidic amino acids from peptide substrates; forms a 12-subunit homo-oligomer; M18 metalloprotease family [Source:SGD;Acc:S000001155]
H	YHR114W	BZZ1	1135	-353.2	4	SH3 domain protein implicated in the regulation of actin polymerization, able to recruit actin polymerization machinery through its SH3 domains, colocalizes with cortical actin patches and Las17p, interacts with type I myosins [Source:SGD;Acc:S000001156]
H	YHR115C	DMA1	414	-143.8	4	Protein involved in ubiquitin ligation; plays a role in regulating spindle position and orientation; functionally redundant with Dma2p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr. [Source:SGD;Acc:S000001157]
H	YHR116W	COX23	216	-70.3	4	Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000001158]
H	YHR117W	TOM71	903	-390.7	4	Mitochondrial outer membrane protein with similarity to Tom70p; probable minor component of the TOM (translocase of outer membrane) complex responsible for recognition and import of mitochondrially directed proteins [Source:SGD;Acc:S000001159]
H	YHR118C	ORC6	236	-181.6	4	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; phosphorylated by Cdc28p [Source:SGD;Acc:S000001160]
H	YHR119W	SET1	605	-275.8	4	Histone methyltransferase, subunit of the COMPASS (Set1C) complex; COMPASS methylates histone H3K4; Set1p-dependent H3K4 trimethylation recruits Nrd1p, allowing efficient termination of snoRNAs and cryptic unstable transcripts (CUTs) by Nrd1p-Nab3p-  pathway; modulates histone acetylation levels in promoter proximal regions to ensure efficient Nrd1p-dependent termination; required in transcriptional silencing near telomeres and at silent mating type loci; has a SET domain [Source:SGD;Acc:S000001161]
H	YHR120W	MSH1	93	-167.4	4	DNA-binding protein of the mitochondria involved in repair of mitochondrial DNA, has ATPase activity and binds to DNA mismatches; has homology to E. coli MutS; transcription is induced during meiosis [Source:SGD;Acc:S000001162]
H	YHR121W	LSM12	1072	-182.1	4	Protein of unknown function that may function in RNA processing; interacts with Pbp1p and Pbp4p and associates with ribosomes; contains an RNA-binding LSM domain and an AD domain; GFP-fusion protein is induced by the DNA-damaging agent MMS [Source:SGD;Acc:S000001163]
H	YHR122W	CIA2	353	-94.3	4	Protein of unknown function required for establishment of sister chromatid cohesion; synthetically lethal with RFC5, an RF-C subunit that links replication to cohesion establishment; YHR122W is an essential gene [Source:SGD;Acc:S000001164]
H	YHR123W	EPT1	179	-49.5	4	sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability [Source:SGD;Acc:S000001165]
H	YHR124W	NDT80	33	-14.2	2	Meiosis-specific transcription factor required for exit from pachytene and for full meiotic recombination; activates middle sporulation genes; competes with Sum1p for binding to promoters containing middle sporulation elements (MSE) [Source:SGD;Acc:S000001166]
H	YHR125W	YHR125W	1	-0.1	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001167]
H	YHR126C	ANS1	2	0	1	Putative protein of unknown function; transcription dependent upon Azf1p [Source:SGD;Acc:S000001168]
H	YHR127W	YHR127W	585	-181.4	4	Protein of unknown function; localizes to the nucleus; required for asymmetric localization of Kar9p during mitosis [Source:SGD;Acc:S000001169]
H	YHR128W	FUR1	2129	-289.2	4	Uracil phosphoribosyltransferase, synthesizes UMP from uracil; involved in the pyrimidine salvage pathway [Source:SGD;Acc:S000001170]
H	YHR129C	ARP1	68	-87	4	Actin-related protein of the dynactin complex; required for spindle orientation and nuclear migration; putative ortholog of mammalian centractin [Source:SGD;Acc:S000001171]
H	YHR130C	YHR130C	2	-1.3	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001172]
H	YHR131C	YHR131C	129	-78.4	4	Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; overexpression causes cell cycle delay or arrest; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study [Source:SGD;Acc:S000001173]
H	YHR131W-A	YHR131W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YHR131C [Source:SGD;Acc:S000028782]
H	YHR132C	ECM14	999	-507.4	4	Putative metalloprotease with similarity to the zinc carboxypeptidase family, required for normal cell wall assembly [Source:SGD;Acc:S000001174]
H	YHR132W-A	IGO2	750	-160.3	4	Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo1p [Source:SGD;Acc:S000007496]
H	YHR133C	NSG1	603	-147.7	4	Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins [Source:SGD;Acc:S000001175]
H	YHR134W	WSS1	10	-510.4	4	Sumoylated protein that localizes to a single spot on the nuclear periphery of mother cells but not daughters; interacts genetically with SMT3; UV-sensitive mutant phenotype and genetic interactions suggest a role in the DNA damage response [Source:SGD;Acc:S000001176]
H	YHR135C	YCK1	1427	-1933.9	4	Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck2p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck2p [Source:SGD;Acc:S000001177]
H	YHR136C	SPL2	66	-43.5	4	Protein with similarity to cyclin-dependent kinase inhibitors; downregulates low-affinity phosphate transport during phosphate limitation; overproduction suppresses a plc1 null mutation; GFP-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001178]
H	YHR137C-A	YHR137C-A	27	-2	2	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene ARO9/YHR137W; identified by gene-trapping, expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028649]
H	YHR137W	ARO9	1161	-730.5	4	Aromatic aminotransferase II, catalyzes the first step of tryptophan, phenylalanine, and tyrosine catabolism [Source:SGD;Acc:S000001179]
H	YHR138C	YHR138C	446	-135.9	4	Putative protein of unknown function; has similarity to Pbi2p; double null mutant lacking Pbi2p and Yhr138p exhibits highly fragmented vacuoles [Source:SGD;Acc:S000001180]
H	YHR139C	SPS100	176	-184.5	4	Protein required for spore wall maturation; expressed during sporulation; may be a component of the spore wall; expression also induced in cells treated with the mycotoxin patulin [Source:SGD;Acc:S000001181]
H	YHR139C-A	YHR139C-A	11	-2.5	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003533]
H	YHR140W	YHR140W	13	-9.6	4	Putative integral membrane protein of unknown function [Source:SGD;Acc:S000001182]
H	YHR141C	RPL42B	1508	-94.2	4	Protein component of the large (60S) ribosomal subunit, identical to Rpl42Ap and has similarity to rat L44; required for propagation of the killer toxin-encoding M1 double-stranded RNA satellite of the L-A double-stranded RNA virus [Source:SGD;Acc:S000001183]
H	YHR142W	CHS7	142	-31.5	4	Protein of unknown function, involved in chitin biosynthesis by regulating Chs3p export from the ER [Source:SGD;Acc:S000001184]
H	YHR143W	DSE2	15	-11.7	3	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother; expression is repressed by cAMP [Source:SGD;Acc:S000001186]
H	YHR143W-A	RPC10	1192	-92.4	4	RNA polymerase subunit ABC10-alpha, found in RNA polymerase complexes I, II, and III [Source:SGD;Acc:S000001185]
H	YHR144C	DCD1	235	-133.1	4	Deoxycytidine monophosphate (dCMP) deaminase required for dCTP and dTTP synthesis; expression is NOT cell cycle regulated [Source:SGD;Acc:S000001187]
H	YHR145C	YHR145C	3	-1.2	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001188]
H	YHR146W	CRP1	2468	-698.1	4	Protein that binds to cruciform DNA structures [Source:SGD;Acc:S000001189]
H	YHR147C	MRPL6	399	-123.3	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000001190]
H	YHR148W	IMP3	862	-141.2	4	Component of the SSU processome, which is required for pre-18S rRNA processing, essential protein that interacts with Mpp10p and mediates interactions of Imp4p and Mpp10p with U3 snoRNA [Source:SGD;Acc:S000001191]
H	YHR149C	SKG6	588	-273.2	4	Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p [Source:SGD;Acc:S000001192]
H	YHR150W	PEX28	100	-199.7	4	Peroxisomal integral membrane peroxin, involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p [Source:SGD;Acc:S000001193]
H	YHR151C	MTC6	27	-33.2	4	Protein of unknown function; mtc6 is synthetically sick with cdc13-1 [Source:SGD;Acc:S000001194]
H	YHR152W	SPO12	45	-13.8	4	Nucleolar protein of unknown function, positive regulator of mitotic exit; involved in regulating release of Cdc14p from the nucleolus in early anaphase, may play similar role in meiosis [Source:SGD;Acc:S000001195]
H	YHR153C	SPO16	0	nf	1	Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation [Source:SGD;Acc:S000001196]
H	YHR154W	RTT107	596	-426	4	Protein implicated in Mms22-dependent DNA repair during S phase; involved in recruiting the SMC5/6 complex to double-strand breaks; DNA damage induces phosphorylation by Mec1p at one or more SQ/TQ motifs; interacts with Mms22p and Slx4p; has four BR  ains; has a role in regulation of Ty1 transposition [Source:SGD;Acc:S000001197]
H	YHR155W	YSP1	150	-260.6	4	Mitochondrial protein with a potential role in promoting mitochondrial fragmentation during programmed cell death in response to high levels of alpha-factor mating pheromone or the drug amiodarone [Source:SGD;Acc:S000001198]
H	YHR156C	LIN1	116	-146.5	4	Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication [Source:SGD;Acc:S000001199]
H	YHR157W	REC104	5	-2.8	2	Protein involved in early stages of meiotic recombination; required for meiotic crossing over; forms a complex with Rec102p and Spo11p necessary during the initiation of recombination [Source:SGD;Acc:S000001200]
H	YHR158C	KEL1	1535	-1184.6	4	Protein required for proper cell fusion and cell morphology; functions in a complex with Kel2p to negatively regulate mitotic exit, interacts with Tem1p and Lte1p; localizes to regions of polarized growth; potential Cdc28p substrate [Source:SGD;Acc:S000001201]
H	YHR159W	TDA11	366	-175.3	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; potential Cdc28p substrate; null mutant is sensitive to expression of the top1-T722A allele [Source:SGD;Acc:S000001202]
H	YHR160C	PEX18	4	-6	2	Peroxin required for targeting of peroxisomal matrix proteins containing PTS2; interacts with Pex7p; partially redundant with Pex21p [Source:SGD;Acc:S000001203]
H	YHR161C	YAP1801	262	-150.3	4	Protein involved in clathrin cage assembly; binds Pan1p and clathrin; homologous to Yap1802p, member of the AP180 protein family [Source:SGD;Acc:S000001204]
H	YHR162W	MPC2	99	-88.9	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion [Source:SGD;Acc:S000001205]
H	YHR163W	SOL3	1588	-225.7	4	6-phosphogluconolactonase, catalyzes the second step of the pentose phosphate pathway; weak multicopy suppressor of los1-1 mutation; homologous to Sol2p and Sol1p [Source:SGD;Acc:S000001206]
H	YHR164C	DNA2	253	-290.8	4	Tripartite DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, and helicase activities; required for Okazaki fragment processing; involved in DNA repair; cell-cycle dependent localization [Source:SGD;Acc:S000001207]
H	YHR165C	PRP8	596	-1251.6	4	Component of the U4/U6-U5 snRNP complex, involved in the second catalytic step of splicing; mutations of human Prp8 cause retinitis pigmentosa [Source:SGD;Acc:S000001208]
H	YHR165W-A	YHR165W-A	8	-9.8	1	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028783]
H	YHR166C	CDC23	152	-297.3	4	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [Source:SGD;Acc:S000001209]
H	YHR167W	THP2	290	-135.3	4	Subunit of the THO complex, which connects transcription elongation and mitotic recombination, and of the TREX complex, which is recruited to activated genes and couples transcription to mRNA export; involved in telomere maintenance [Source:SGD;Acc:S000001210]
H	YHR168W	MTG2	133	-98	4	Putative GTPase, member of the Obg family; peripheral protein of the mitochondrial inner membrane that associates with the large ribosomal subunit; required for mitochondrial translation, possibly via a role in ribosome assembly [Source:SGD;Acc:S000001211]
H	YHR169W	DBP8	678	-251.6	4	ATPase, putative RNA helicase of the DEAD-box family; component of 90S preribosome complex involved in production of 18S rRNA and assembly of 40S small ribosomal subunit; ATPase activity stimulated by association with Esf2p [Source:SGD;Acc:S000001212]
H	YHR170W	NMD3	1609	-399.7	4	Protein involved in nuclear export of the large ribosomal subunit; acts as a Crm1p-dependent adapter protein for export of nascent ribosomal subunits through the nuclear pore complex [Source:SGD;Acc:S000001213]
H	YHR171W	ATG7	241	-269.4	4	Autophagy-related protein and dual specificity member of the E1 family of ubiquitin-activating enzymes; mediates the conjugation of Atg12p with Atg5p and Atg8p with phosphatidylethanolamine, required steps in autophagosome formation [Source:SGD;Acc:S000001214]
H	YHR172W	SPC97	203	-288.9	4	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque [Source:SGD;Acc:S000001215]
H	YHR173C	YHR173C	0	nf	1	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001216]
H	YHR174W	ENO2	7956	-3168.7	4	Enolase II, a phosphopyruvate hydratase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate during glycolysis and the reverse reaction during gluconeogenesis; expression is induced in response to glucose [Source:SGD;Acc:S000001217]
H	YHR175W	CTR2	7	-11.7	2	Putative low-affinity copper transporter of the vacuolar membrane; mutation confers resistance to toxic copper concentrations, while overexpression confers resistance to copper starvation [Source:SGD;Acc:S000001218]
H	YHR175W-A	YHR175W-A	0	nf	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028553]
H	YHR176W	FMO1	135	-141.1	4	Flavin-containing monooxygenase, localized to the cytoplasmic face of the ER membrane; catalyzes oxidation of biological thiols to maintain the ER redox buffer ratio for correct folding of disulfide-bonded proteins [Source:SGD;Acc:S000001219]
H	YHR177W	YHR177W	41	-71.6	4	Putative protein of unknown function; overexpression causes a cell cycle delay or arrest [Source:SGD;Acc:S000001220]
H	YHR178W	STB5	96	-113.3	4	Transcription factor, involved in regulating multidrug resistance and oxidative stress response; forms a heterodimer with Pdr1p; contains a Zn(II)2Cys6 zinc finger domain that interacts with a pleiotropic drug resistance element in vitro [Source:SGD;Acc:S000001221]
H	YHR179W	OYE2	2910	-1085.8	4	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye3p with different ligand binding and catalytic properties; may be involved in sterol metabolism, oxidative stress response, and programmed cell death [Source:SGD;Acc:S000001222]
H	YHR180C-B	YHR180C-B	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YHR180W-A [Source:SGD;Acc:S000028554]
H	YHR180W	YHR180W	2	-5.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001223]
H	YHR180W-A	YHR180W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious ORF YHR180C-B and long terminal repeat YHRCsigma3 [Source:SGD;Acc:S000028555]
H	YHR181W	SVP26	317	-97.9	4	Integral membrane protein of the early Golgi apparatus and endoplasmic reticulum, involved in COP II vesicle transport; may also function to promote retention of proteins in the early Golgi compartment [Source:SGD;Acc:S000001224]
H	YHR182C-A	YHR182C-A	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028784]
H	YHR182W	YHR182W	214	-167.1	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and cytoplasm [Source:SGD;Acc:S000001225]
H	YHR183W	GND1	4055	-2030.4	4	6-phosphogluconate dehydrogenase (decarboxylating), catalyzes an NADPH regenerating reaction in the pentose phosphate pathway; required for growth on D-glucono-delta-lactone and adaptation to oxidative stress [Source:SGD;Acc:S000001226]
H	YHR184W	SSP1	46	-24.3	4	Protein involved in the control of meiotic nuclear division and coordination of meiosis with spore formation; transcription is induced midway through meiosis [Source:SGD;Acc:S000001227]
H	YHR185C	PFS1	3	-1.2	1	Sporulation protein required for prospore membrane formation at selected spindle poles, ensures functionality of all four spindle pole bodies during meiosis II; not required for meiotic recombination or meiotic chromosome segregation [Source:SGD;Acc:S000001228]
H	YHR186C	KOG1	723	-685	4	Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors [Source:SGD;Acc:S000001229]
H	YHR187W	IKI1	396	-227.4	4	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; iki1 mutations confer resistance to the K. lactis toxin zymocin [Source:SGD;Acc:S000001230]
H	YHR188C	GPI16	635	-239.1	4	Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-Tp homolog [Source:SGD;Acc:S000001231]
H	YHR189W	PTH1	61	-58.5	4	One of two (see also PTH2) mitochondrially-localized peptidyl-tRNA hydrolases; dispensable for respiratory growth on rich medium, but required for respiratory growth on minimal medium [Source:SGD;Acc:S000001232]
H	YHR190W	ERG9	1806	-652.5	4	Farnesyl-diphosphate farnesyl transferase (squalene synthase), joins two farnesyl pyrophosphate moieties to form squalene in the sterol biosynthesis pathway [Source:SGD;Acc:S000001233]
H	YHR191C	CTF8	113	-54.7	4	Subunit of a complex with Ctf18p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion [Source:SGD;Acc:S000001234]
H	YHR192W	LNP1	388	-162.7	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000001235]
H	YHR193C	EGD2	3202	-737.9	4	Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes [Source:SGD;Acc:S000001236]
H	YHR193C-A	YHR193C-A	13	-4.9	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified ORF MDM31 [Source:SGD;Acc:S000028785]
H	YHR194W	MDM31	26	-70.6	4	Mitochondrial inner membrane protein with similarity to Mdm32p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34 [Source:SGD;Acc:S000001237]
H	YHR195W	NVJ1	364	-201.8	4	Nuclear envelope protein, anchored to the nuclear inner membrane, that interacts with the vacuolar membrane protein Vac8p to promote formation of nucleus-vacuole junctions during piecemeal microautophagy of the nucleus (PMN) [Source:SGD;Acc:S000001238]
H	YHR196W	UTP9	1161	-370.6	4	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [Source:SGD;Acc:S000001239]
H	YHR197W	RIX1	1096	-457.8	4	Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles [Source:SGD;Acc:S000001240]
H	YHR198C	AIM18	400	-148.9	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000001241]
H	YHR199C	AIM46	762	-204.8	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000001242]
H	YHR199C-A	NBL1	52	-28.7	4	Subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates mitotic chromosome segregation; not required for the kinase activity of the complex; mediates the interaction of Sli15p and Bir1p [Source:SGD;Acc:S000029704]
H	YHR200W	RPN10	1625	-287.1	4	Non-ATPase base subunit of the 19S regulatory particle (RP) of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the RP; binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein [Source:SGD;Acc:S000001243]
H	YHR201C	PPX1	992	-330	4	Exopolyphosphatase, hydrolyzes inorganic polyphosphate (poly P) into Pi residues; located in the cytosol, plasma membrane, and mitochondrial matrix [Source:SGD;Acc:S000001244]
H	YHR202W	YHR202W	120	-205.7	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole, while HA-tagged protein is found in the soluble fraction, suggesting cytoplasmic localization [Source:SGD;Acc:S000001245]
H	YHR203C	RPS4B	4641	-1051.6	4	Protein component of the small (40S) ribosomal subunit; identical to Rps4Ap and has similarity to rat S4 ribosomal protein [Source:SGD;Acc:S000001246]
H	YHR204W	MNL1	100	-152.9	4	Alpha-1,2-specific exomannosidase of the endoplasmic reticulum; in complex with Pdi1p, generates a Man7GlcNac2 oligosaccharide signal on glycoproteins destined for ubiquitin-proteasome degradation [Source:SGD;Acc:S000001247]
H	YHR205W	SCH9	1050	-1352.5	4	Protein kinase involved in transcriptional activation of osmostress-responsive genes; regulates G1 progression, cAPK activity, nitrogen activation of the FGM pathway; involved in life span regulation; homologous to mammalian Akt/PKB [Source:SGD;Acc:S000001248]
H	YHR206W	SKN7	450	-140.2	4	Nuclear response regulator and transcription factor; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; part of a branched two-component signaling system; required for optimal induction of heat-shock genes in response  idative stress; involved in osmoregulation [Source:SGD;Acc:S000001249]
H	YHR207C	SET5	365	-311.2	4	Putative S-adenosylmethionine-dependent methyltransferase; zinc-finger protein, contains one canonical and two unusual fingers in unusual arrangements; deletion enhances replication of positive-strand RNA virus [Source:SGD;Acc:S000001250]
H	YHR208W	BAT1	3096	-949.7	4	Mitochondrial branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA biosynthesis; homolog of murine ECA39; highly expressed during logarithmic phase and repressed during stationary phase [Source:SGD;Acc:S000001251]
H	YHR209W	CRG1	264	-195.3	4	S-AdoMet-dependent methyltransferase involved in lipid homeostasis; mediates resistance to a drug cantharidin [Source:SGD;Acc:S000001252]
H	YHR210C	YHR210C	17	-15.1	2	Putative protein of unknown function; non-essential gene; highly expressed under anaeorbic conditions; sequence similarity to aldose 1-epimerases such as GAL10 [Source:SGD;Acc:S000001253]
H	YHR211W	FLO5	35	-39.2	3	Lectin-like cell wall protein (flocculin) involved in flocculation, binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin resistant but heat labile; similar to Flo1p [Source:SGD;Acc:S000001254]
H	YHR212C	YHR212C	5	-2.1	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001255]
H	YHR212W-A	YHR212W-A	0	nf	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028650]
H	YHR213W	YHR213W	0	nf	1	Possible pseudogene; has similarity to Flo1p, which is a lectin-like protein involved in flocculation [Source:SGD;Acc:S000001256]
H	YHR213W-A	YHR213W-A	6	-11.1	2	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028651]
H	YHR213W-B	YHR213W-B	0	nf	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028652]
H	YHR214C-B	YHR214C-B	4908	-2145.1	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000003534]
H	YHR214C-C	YHR214C-C	4579	-1515.7	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007421]
H	YHR214C-D	YHR214C-D	0	nf	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028653]
H	YHR214C-E	YHR214C-E	1	-2.1	2	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028654]
H	YHR214W	YHR214W	23	-15.2	4	Putative protein of unknown function; predicted to be a glycosylphosphatidylinositol-modified (GPI) protein [Source:SGD;Acc:S000001257]
H	YHR214W-A	YHR214W-A	6	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; similar to the fungal specific protein encoded by YAR068W; induced by zinc deficiency [Source:SGD;Acc:S000003535]
H	YHR215W	PHO12	801	-562.8	4	One of three repressible acid phosphatases, a glycoprotein that is transported to the cell surface by the secretory pathway; nearly identical to Pho11p; upregulated by phosphate starvation [Source:SGD;Acc:S000001258]
H	YHR216W	IMD2	3433	-1472.8	4	Inosine monophosphate dehydrogenase, catalyzes the rate-limiting step in GTP biosynthesis, expression is induced by mycophenolic acid resulting in resistance to the drug, expression is repressed by nutrient limitatio [Source:SGD;Acc:S000001259]
H	YHR217C	YHR217C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; located in the telomeric region TEL08R. [Source:SGD;Acc:S000001260]
H	YHR218W	YHR218W	240	-188.2	4	Helicase-like protein encoded within the telomeric Y' element [Source:SGD;Acc:S000001261]
H	YHR218W-A	YHR218W-A	71	-17.2	4	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028786]
H	YHR219C-A	YHR219C-A	43	-1.6	1	Dubious open reading frame unlikely to encode a functional protein; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028655]
H	YHR219W	YHR219W	169	-118.9	4	Putative protein of unknown function with similarity to helicases; located in the telomere region on the right arm of chromosome VIII [Source:SGD;Acc:S000001262]
I	YIL001W	YIL001W	57	-130.5	4	Putative protein of unknown function; contains a BTB/POZ domain which generally function in protein interactions; deletion slightly improved competitive fitness in rich media; GFP-tagged protein is localized to the cytoplasm [Source:SGD;Acc:S000001263]
I	YIL002C	INP51	234	-1266.9	4	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, synaptojanin-like protein with an N-terminal Sac1 domain, plays a role in phosphatidylinositol 4,5-bisphosphate homeostasis and in endocytosis; null mutation confers cold-tolerant growth [Source:SGD;Acc:S000001264]
I	YIL002W-A	YIL002W-A	675	-114.2	4	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028835]
I	YIL003W	CFD1	255	-149.1	4	Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol [Source:SGD;Acc:S000001265]
I	YIL004C	BET1	307	-158.5	4	Type II membrane protein required for vesicular transport between the endoplasmic reticulum and Golgi complex; v-SNARE with similarity to synaptobrevins [Source:SGD;Acc:S000001266]
I	YIL005W	EPS1	760	-554.8	4	ER protein with chaperone and co-chaperone activity, involved in retention of resident ER proteins; has a role in recognizing proteins targeted for ER-associated degradation (ERAD), member of the protein disulfide isomerase family [Source:SGD;Acc:S000001267]
I	YIL006W	YIA6	11	-113.6	3	Mitochondrial NAD+ transporter, involved in the transport of NAD+ into the mitochondria (see also YEA6); member of the mitochondrial carrier subfamily; disputed role as a pyruvate transporter; has putative mouse and human orthologs [Source:SGD;Acc:S000001268]
I	YIL007C	NAS2	333	-104.6	4	Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasomal regulatory particle (RP); similar to mammalian proteasomal modulator subunit; non-essential gene; interacts with Rpn4p [Source:SGD;Acc:S000001269]
I	YIL008W	URM1	370	-70	4	Ubiquitin-like protein involved in thiolation of cytoplasmic tRNAs; receives sulfur from the E1-like enzyme Uba4p and transfers it to tRNA; also functions as a protein tag with roles in nutrient sensing and oxidative stress response [Source:SGD;Acc:S000001270]
I	YIL009C-A	EST3	4	-4.3	2	Component of the telomerase holoenzyme, involved in telomere replication [Source:SGD;Acc:S000006432]
I	YIL009W	FAA3	1179	-1040.8	4	Long chain fatty acyl-CoA synthetase, activates imported fatty acids; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000001271]
I	YIL010W	DOT5	824	-229.7	4	Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth [Source:SGD;Acc:S000001272]
I	YIL011W	TIR3	20	-22.8	4	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth [Source:SGD;Acc:S000001273]
I	YIL012W	YIL012W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001274]
I	YIL013C	PDR11	60	-44.5	4	ATP-binding cassette (ABC) transporter, multidrug transporter involved in multiple drug resistance; mediates sterol uptake when sterol biosynthesis is compromisedregulated by Pdr1p; required for anaerobic growth [Source:SGD;Acc:S000001275]
I	YIL014C-A	YIL014C-A	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000003536]
I	YIL014W	MNT3	216	-159.6	4	Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation [Source:SGD;Acc:S000001276]
I	YIL015W	BAR1	700	-405.2	4	Aspartyl protease secreted into the periplasmic space of mating type a cells, helps cells find mating partners, cleaves and inactivates alpha factor allowing cells to recover from alpha-factor-induced cell cycle arrest [Source:SGD;Acc:S000001277]
I	YIL016W	SNL1	673	-92.9	4	Protein of unknown function proposed to be involved in nuclear pore complex biogenesis and maintenance as well as protein folding; has similarity to the mammalian BAG-1 protein [Source:SGD;Acc:S000001278]
I	YIL017C	VID28	201	-803.6	4	Protein involved in proteasome-dependent catabolite degradation of fructose-1,6-bisphosphatase (FBPase); localized to the nucleus and the cytoplasm [Source:SGD;Acc:S000001279]
I	YIL018W	RPL2B	4418	-1495.4	4	Protein component of the large (60S) ribosomal subunit, identical to Rpl2Ap and has similarity to E. coli L2 and rat L8 ribosomal proteins; expression is upregulated at low temperatures [Source:SGD;Acc:S000001280]
I	YIL019W	FAF1	157	-146.6	4	Protein required for pre-rRNA processing and 40S ribosomal subunit assembly [Source:SGD;Acc:S000001281]
I	YIL020C	HIS6	542	-164.7	4	Phosphoribosyl-5-amino-1-phosphoribosyl-4-imidazolecarboxiamide isomerase, catalyzes the fourth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts [Source:SGD;Acc:S000001282]
I	YIL020C-A	YIL020C-A	4	-1.6	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028787]
I	YIL021C-A	YIL021C-A	3	-2.4	2	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene RPB3/YIL021W; identified by gene-trapping, expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028656]
I	YIL021W	RPB3	976	-309.2	4	RNA polymerase II third largest subunit B44, part of central core; similar to prokaryotic alpha subunit [Source:SGD;Acc:S000001283]
I	YIL022W	TIM44	1640	-337	4	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); tethers the import motor and regulatory factors (PAM complex) to the translocation channel (Tim23p-Tim17p core complex) [Source:SGD;Acc:S000001284]
I	YIL023C	YKE4	5	-19.7	2	Zinc transporter; localizes to the ER; null mutant is sensitive to calcofluor white, leads to zinc accumulation in cytosol; ortholog of the mouse KE4 and member of the ZIP (ZRT, IRT-like Protein) family [Source:SGD;Acc:S000001285]
I	YIL024C	YIL024C	33	-25.7	4	Putative protein of unknown function; non-essential gene; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p [Source:SGD;Acc:S000001286]
I	YIL025C	YIL025C	5	-1.7	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001287]
I	YIL026C	IRR1	545	-355.3	4	Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability [Source:SGD;Acc:S000001288]
I	YIL027C	EMC5	674	-103.1	4	Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response, and also shows K1 killer toxin resistance [Source:SGD;Acc:S000001289]
I	YIL028W	YIL028W	1	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001290]
I	YIL029C	YIL029C	2	-1.8	1	Putative protein of unknown function; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) [Source:SGD;Acc:S000001291]
I	YIL029W-A	YIL029W-A	4	-1.9	1	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028788]
I	YIL030C	SSM4	972	-522.2	4	Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation [Source:SGD;Acc:S000001292]
I	YIL030W-A	YIL030W-A	2	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIL031W. [Source:SGD;Acc:S000028789]
I	YIL031W	ULP2	257	-161.9	4	Peptidase that deconjugates Smt3/SUMO-1 peptides from proteins, plays a role in chromosome cohesion at centromeric regions and recovery from checkpoint arrest induced by DNA damage or DNA replication defects; potential Cdc28p substrate [Source:SGD;Acc:S000001293]
I	YIL032C	YIL032C	1	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001294]
I	YIL033C	BCY1	1900	-800.8	4	Regulatory subunit of the cyclic AMP-dependent protein kinase (PKA), a component of a signaling pathway that controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation [Source:SGD;Acc:S000001295]
I	YIL034C	CAP2	1460	-291	4	Beta subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches [Source:SGD;Acc:S000001296]
I	YIL035C	CKA1	753	-733.2	4	Alpha catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerases [Source:SGD;Acc:S000001297]
I	YIL036W	CST6	831	-297.6	4	Basic leucine zipper (bZIP) transcription factor of the ATF/CREB family, proposed to be a regulator of oleate responsive genes; involved in utilization of non-optimal carbon sources and chromosome stability [Source:SGD;Acc:S000001298]
I	YIL037C	PRM2	13	-11.4	2	Pheromone-regulated protein, predicted to have 4 transmembrane segments and a coiled coil domain; regulated by Ste12p; required for efficient nuclear fusion [Source:SGD;Acc:S000001299]
I	YIL038C	NOT3	1651	-533.9	4	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation [Source:SGD;Acc:S000001300]
I	YIL039W	TED1	461	-190	4	Conserved phosphoesterase domain-containing protein that acts together with Emp24p/Erv25p in cargo exit from the ER; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) [Source:SGD;Acc:S000001301]
I	YIL040W	APQ12	116	-84.3	4	Protein required for nuclear envelope morphology, nuclear pore complex localization, mRNA export from the nucleus; exhibits synthetic lethal genetic interactions with genes involved in lipid metabolism [Source:SGD;Acc:S000001302]
I	YIL041W	GVP36	2896	-537	4	BAR domain-containing protein that localizes to both early and late Golgi vesicles; required for adaptation to varying nutrient concentrations, fluid-phase endocytosis, polarization of the actin cytoskeleton, and vacuole biogenesis [Source:SGD;Acc:S000001303]
I	YIL042C	PKP1	160	-724.1	4	Mitochondrial protein kinase involved in negative regulation of pyruvate dehydrogenase complex activity by phosphorylating the ser-133 residue of the Pda1p subunit; acts in concert with kinase Pkp2p and phosphatases Ptc5p and Ptc6p [Source:SGD;Acc:S000001304]
I	YIL043C	CBR1	2084	-537	4	Microsomal cytochrome b reductase, not essential for viability; also detected in mitochondria; mutation in conserved NADH binding domain of the human ortholog results in type I methemoglobinemia [Source:SGD;Acc:S000001305]
I	YIL044C	AGE2	875	-162.3	4	ADP-ribosylation factor (ARF) GTPase activating protein (GAP) effector, involved in Trans-Golgi-Network (TGN) transport; contains C2C2H2 cysteine/histidine motif [Source:SGD;Acc:S000001306]
I	YIL045W	PIG2	226	-1109.7	4	Putative type-1 protein phosphatase targeting subunit that tethers Glc7p type-1 protein phosphatase to Gsy2p glycogen synthase [Source:SGD;Acc:S000001307]
I	YIL046W	MET30	219	-200.4	4	F-box protein containing five copies of the WD40 motif, controls cell cycle function, sulfur metabolism, and methionine biosynthesis as part of the ubiquitin ligase complex; interacts with and regulates Met4p, localizes within the nucleus [Source:SGD;Acc:S000001308]
I	YIL046W-A	YIL046W-A	0	nf	1	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028836]
I	YIL047C	SYG1	409	-234.4	4	Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency [Source:SGD;Acc:S000001309]
I	YIL047C-A	YIL047C-A	7	-5.2	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028790]
I	YIL048W	NEO1	576	-353.5	4	Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus [Source:SGD;Acc:S000001310]
I	YIL049W	DFG10	15	-32.2	3	Probable polyprenol reductase that catalyzes conversion of polyprenol to dolichol, the precursor for N-glycosylation; involved in filamentous growth; mutations in human ortholog SRD5A3 confer CDG (Congenital Disorders of Glycosylation) [Source:SGD;Acc:S000001311]
I	YIL050W	PCL7	193	-351.5	4	Pho85p cyclin of the Pho80p subfamily, forms a functional kinase complex with Pho85p which phosphorylates Mmr1p and is regulated by Pho81p; involved in glycogen metabolism, expression is cell-cycle regulated [Source:SGD;Acc:S000001312]
I	YIL051C	MMF1	2733	-339.6	4	Mitochondrial protein required for transamination of isoleucine but not of valine or leucine; may regulate specificity of branched-chain transaminases Bat1p and Bat2p; interacts genetically with mitochondrial ribosomal protein genes [Source:SGD;Acc:S000001313]
I	YIL052C	RPL34B	2863	-281	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl34Ap and has similarity to rat L34 ribosomal protein [Source:SGD;Acc:S000001314]
I	YIL053W	GPP1	4049	-579.7	4	Constitutively expressed isoform of DL-glycerol-3-phosphatase; involved in glycerol biosynthesis, induced in response to both anaerobic and, along with the Hor2p/Gpp2p isoform, osmotic stress [Source:SGD;Acc:S000001315]
I	YIL054W	YIL054W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001316]
I	YIL055C	YIL055C	244	-149	4	Putative protein of unknown function [Source:SGD;Acc:S000001317]
I	YIL056W	VHR1	179	-125.3	4	Transcriptional activator, required for the vitamin H-responsive element (VHRE) mediated induction of VHT1 (Vitamin H transporter) and BIO5 (biotin biosynthesis intermediate transporter) in response to low biotin concentrations [Source:SGD;Acc:S000001318]
I	YIL057C	RGI2	198	-243.5	4	Protein of unknown function involved in energy metabolism under respiratory conditions; expression induced under carbon limitation and repressed under high glucose [Source:SGD;Acc:S000001319]
I	YIL058W	YIL058W	5	-1.3	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001320]
I	YIL059C	YIL059C	8	-7.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YIL060W [Source:SGD;Acc:S000001321]
I	YIL060W	YIL060W	12	-4.3	2	Putative protein of unknown function; mutant accumulates less glycogen than does wild type; null mutation results in a decrease in plasma membrane electron transport; YIL060W is not an essential gene [Source:SGD;Acc:S000001322]
I	YIL061C	SNP1	195	-469.4	4	Component of U1 snRNP required for mRNA splicing via spliceosome; substrate of the arginine methyltransferase Hmt1p; may interact with poly(A) polymerase to regulate polyadenylation; homolog of human U1 70K protein [Source:SGD;Acc:S000001323]
I	YIL062C	ARC15	1340	-219.9	4	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity [Source:SGD;Acc:S000001324]
I	YIL063C	YRB2	1263	-247	4	Protein of unknown function involved in nuclear processes of the Ran-GTPase cycle; involved in nuclear protein export; contains Ran Binding Domain and FxFG repeats; interacts with Srm1p, GTP-Gsp1p, Rna1p and Crm1p; is not essential [Source:SGD;Acc:S000001325]
I	YIL064W	EFM4	436	-149.9	4	Probable lysine methyltransferase involved in the dimethylation of eEF1A (Tef1p/Tef2p); sequence similarity to S-adenosylmethionine-dependent methyltransferases of the seven beta-strand family; role in vesicular transport [Source:SGD;Acc:S000001326]
I	YIL065C	FIS1	670	-235	4	Protein involved in mitochondrial membrane fission and peroxisome abundance; required for localization of Dnm1p and Mdv1p during mitochondrial division; mediates ethanol-induced apoptosis and ethanol-induced mitochondrial fragmentation [Source:SGD;Acc:S000001327]
I	YIL066C	RNR3	1357	-495.7	4	Minor isoform of the large subunit of ribonucleotide-diphosphate reductase; the RNR complex catalyzes rate-limiting step in dNTP synthesis, regulated by DNA replication and DNA damage checkpoint pathways via localization of small subunits [Source:SGD;Acc:S000001328]
I	YIL066W-A	YIL066W-A	5	-3.6	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028791]
I	YIL067C	YIL067C	61	-120.7	4	Uncharacterized protein of unknown function [Source:SGD;Acc:S000001329]
I	YIL068C	SEC6	271	-417.6	4	Essential 88kDa subunit of the exocyst complex, which mediates polarized targeting of secretory vesicles to active sites of exocytosis; dimeric form of Sec6p interacts with Sec9p in vitro and inhibits t-SNARE assembly [Source:SGD;Acc:S000001330]
I	YIL068W-A	YIL068W-A	6	-3.1	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028792]
I	YIL069C	RPS24B	4154	-592	4	Protein component of the small (40S) ribosomal subunit; identical to Rps24Ap and has similarity to rat S24 ribosomal protein [Source:SGD;Acc:S000001331]
I	YIL070C	MAM33	1299	-422.3	4	Acidic protein of the mitochondrial matrix involved in oxidative phosphorylation; related to the human complement receptor gC1q-R [Source:SGD;Acc:S000001332]
I	YIL071C	PCI8	28	-55.3	4	Possible shared subunit of Cop9 signalosome (CSN) and eIF3, binds eIF3b subunit Prt1p, has possible dual functions in transcriptional and translational control, contains a PCI (Proteasome-COP9 signalosome (CSN)-eIF3) domain [Source:SGD;Acc:S000001333]
I	YIL071W-A	YIL071W-A	1	-3.6	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028793]
I	YIL072W	HOP1	33	-16.8	4	Meiosis-specific DNA binding protein that displays Red1p dependent localization to the unsynapsed axial-lateral elements of the synaptonemal complex; required for homologous chromosome synapsis and chiasma formation [Source:SGD;Acc:S000001334]
I	YIL073C	SPO22	21	-5.3	2	Meiosis-specific protein essential for chromosome synapsis, involved in completion of nuclear divisions during meiosis; induced early in meiosis [Source:SGD;Acc:S000001335]
I	YIL074C	SER33	2504	-565.4	4	3-phosphoglycerate dehydrogenase, catalyzes the first step in serine and glycine biosynthesis; isozyme of Ser3p [Source:SGD;Acc:S000001336]
I	YIL075C	RPN2	2913	-897.8	4	Subunit of the 26S proteasome, substrate of the N-acetyltransferase Nat1p [Source:SGD;Acc:S000001337]
I	YIL076W	SEC28	1637	-267.9	4	Epsilon-COP subunit of the coatomer; regulates retrograde Golgi-to-ER protein traffic; stabilizes Cop1p, the alpha-COP and the coatomer complex; non-essential for cell growth [Source:SGD;Acc:S000001338]
I	YIL077C	YIL077C	206	-213	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) [Source:SGD;Acc:S000001339]
I	YIL078W	THS1	3659	-1869.2	4	Threonyl-tRNA synthetase, essential cytoplasmic protein [Source:SGD;Acc:S000001340]
I	YIL079C	AIR1	300	-179	4	Zinc knuckle protein, involved in nuclear RNA processing and degradation as a component of the TRAMP complex; stimulates the poly(A) polymerase activity of Pap2p in vitro; functionally redundant with Air2p [Source:SGD;Acc:S000001341]
I	YIL082W	YIL082W	118	-112	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000001344]
I	YIL082W-A	YIL082W-A	195	-134.1	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000003537]
I	YIL083C	CAB2	857	-373.1	4	Probable phosphopantothenoylcysteine synthetase (PPCS), which catalyzes the second step of coenzyme A biosynthesis from pantothenate; null mutant lethality is complemented by E. coli coaBC (encoding a bifunctional enzyme with PPCS activity) [Source:SGD;Acc:S000001345]
I	YIL084C	SDS3	385	-149	4	Component of the Rpd3p/Sin3p deacetylase complex required for its structural integrity and catalytic activity, involved in transcriptional silencing and required for sporulation; cells defective in SDS3 display pleiotropic phenotypes [Source:SGD;Acc:S000001346]
I	YIL085C	KTR7	149	-132.2	4	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family [Source:SGD;Acc:S000001347]
I	YIL086C	YIL086C	1	-1.1	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001348]
I	YIL087C	AIM19	264	-137	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth [Source:SGD;Acc:S000001349]
I	YIL088C	AVT7	295	-141.2	4	Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters [Source:SGD;Acc:S000001350]
I	YIL089W	YIL089W	2	-1.2	1	Protein of unknown function found in the ER and vacuole lumen; overexpression of YIL089W affects endocytic protein trafficking [Source:SGD;Acc:S000001351]
I	YIL090W	ICE2	254	-70.9	4	Integral ER membrane protein with type-III transmembrane domains; mutations cause defects in cortical ER morphology in both the mother and daughter cells [Source:SGD;Acc:S000001352]
I	YIL091C	UTP25	1060	-301.3	4	Nucleolar protein required for 35S pre-RNA processing and 40S ribosomal subunit biogenesis; contains a DEAD-box RNA helicase-like motif [Source:SGD;Acc:S000001353]
I	YIL092W	YIL092W	18	-24.6	2	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus [Source:SGD;Acc:S000001354]
I	YIL093C	RSM25	449	-227.7	4	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000001355]
I	YIL094C	LYS12	2381	-528.6	4	Homo-isocitrate dehydrogenase, an NAD-linked mitochondrial enzyme required for the fourth step in the biosynthesis of lysine, in which homo-isocitrate is oxidatively decarboxylated to alpha-ketoadipate [Source:SGD;Acc:S000001356]
I	YIL095W	PRK1	532	-2093.7	4	Protein serine/threonine kinase; regulates the organization and function of the actin cytoskeleton and reduces endocytic ability of cell through the phosphorylation of the Pan1p-Sla1p-End3p protein complex [Source:SGD;Acc:S000001357]
I	YIL096C	BMT5	194	-90.4	4	Putative S-adenosylmethionine-dependent methyltransferase; associates with precursors of the 60S ribosomal subunit; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000001358]
I	YIL097W	FYV10	210	-485.3	4	Protein of unknown function, required for survival upon exposure to K1 killer toxin; involved in proteasome-dependent catabolite inactivation of FBPase; contains CTLH domain; plays role in anti-apoptosis [Source:SGD;Acc:S000001359]
I	YIL098C	FMC1	267	-96.9	4	Mitochondrial matrix protein, required for assembly or stability at high temperature of the F1 sector of mitochondrial F1F0 ATP synthase; null mutant temperature sensitive growth on glycerol is suppressed by multicopy expression of Odc1p [Source:SGD;Acc:S000001360]
I	YIL099W	SGA1	27	-88.6	3	Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation [Source:SGD;Acc:S000001361]
I	YIL100C-A	YIL100C-A	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028794]
I	YIL100W	YIL100W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the dubious ORF YIL100C-A [Source:SGD;Acc:S000001362]
I	YIL101C	XBP1	81	-106	4	Transcriptional repressor that binds to promoter sequences of the cyclin genes, CYS3, and SMF2; expression is induced by stress or starvation during mitosis, and late in meiosis; member of the Swi4p/Mbp1p family; potential Cdc28p substrate [Source:SGD;Acc:S000001363]
I	YIL102C	YIL102C	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000001364]
I	YIL102C-A	YIL102C-A	0	nf	1	Putative protein of unknown function, identified based on comparisons of the genome sequences of six Saccharomyces species [Source:SGD;Acc:S000113587]
I	YIL103W	DPH1	481	-185.8	4	Protein required, along with Dph2p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph2p and Kti11p [Source:SGD;Acc:S000001365]
I	YIL104C	SHQ1	409	-251.2	4	Chaperone protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Naf1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; homology with known Hsp90p cochaperones [Source:SGD;Acc:S000001366]
I	YIL105C	SLM1	1011	-285.7	4	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm2p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex [Source:SGD;Acc:S000001367]
I	YIL105W-A	YIL105W-A	0	nf	1	Dubious open reading frame; completely overlaps the verified gene SLM1; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028657]
I	YIL106W	MOB1	826	-788.7	4	Component of the mitotic exit network; associates with and is required for the activation and Cdc15p-dependent phosphorylation of the Dbf2p kinase; required for cytokinesis and cell separation; component of the CCR4 transcriptional complex [Source:SGD;Acc:S000001368]
I	YIL107C	PFK26	918	-437	4	6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A [Source:SGD;Acc:S000001369]
I	YIL108W	YIL108W	1071	-492.2	4	Putative metalloprotease [Source:SGD;Acc:S000001370]
I	YIL109C	SEC24	2322	-716.2	4	Component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sfb2p and Sfb3p [Source:SGD;Acc:S000001371]
I	YIL110W	HPM1	418	-190.6	4	AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance [Source:SGD;Acc:S000001372]
I	YIL111W	COX5B	830	-181.8	4	Subunit Vb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth [Source:SGD;Acc:S000001373]
I	YIL112W	HOS4	620	-313.2	4	Subunit of the Set3 complex, which is a meiotic-specific repressor of sporulation specific genes that contains deacetylase activity; potential Cdc28p substrate [Source:SGD;Acc:S000001374]
I	YIL113W	SDP1	34	-625.9	4	Stress-inducible dual-specificity MAP kinase phosphatase, negatively regulates Slt2p MAP kinase by direct dephosphorylation, diffuse localization under normal conditions shifts to punctate localization after heat shock [Source:SGD;Acc:S000001375]
I	YIL114C	POR2	126	-111.9	4	Putative mitochondrial porin (voltage-dependent anion channel), related to Por1p but not required for mitochondrial membrane permeability or mitochondrial osmotic stability [Source:SGD;Acc:S000001376]
I	YIL115C	NUP159	1856	-2018.8	4	Nucleoporin, subunit of the Nup82 subcomplex of the nuclear pore; part of the nuclear pore that is found exclusively on the cytoplasmic side; required for mRNA export; regulates ADP release from the ATP-dependent RNA helicase Dbp5p [Source:SGD;Acc:S000001377]
I	YIL115W-A	YIL115W-A	1	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene NUP159/YIL115C [Source:SGD;Acc:S000028795]
I	YIL116W	HIS5	1142	-449.9	4	Histidinol-phosphate aminotransferase, catalyzes the seventh step in histidine biosynthesis; responsive to general control of amino acid biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts [Source:SGD;Acc:S000001378]
I	YIL117C	PRM5	248	-64.5	4	Pheromone-regulated protein, predicted to have 1 transmembrane segment; induced during cell integrity signaling [Source:SGD;Acc:S000001379]
I	YIL118W	RHO3	1647	-194.6	4	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins involved in the establishment of cell polarity; GTPase activity positively regulated by the GTPase activating protein (GAP) Rgd1p [Source:SGD;Acc:S000001380]
I	YIL119C	RPI1	136	-111.7	4	Putative transcriptional regulator; overexpression suppresses the heat shock sensitivity of wild-type RAS2 overexpression and also suppresses the cell lysis defect of an mpk1 mutation [Source:SGD;Acc:S000001381]
I	YIL120W	QDR1	27	-14.8	2	Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, ketoconazole, fluconazole, and barban [Source:SGD;Acc:S000001382]
I	YIL121W	QDR2	644	-124.2	4	Multidrug transporter of the major facilitator superfamily, required for resistance to quinidine, barban, cisplatin, and bleomycin; may have a role in potassium uptake [Source:SGD;Acc:S000001383]
I	YIL122W	POG1	239	-84.4	4	Nuclear chromatin-associated protein of unknown function; overexpression promotes recovery from pheromone induced arrest and suppresses the stress sensitivity caused by a mutation in the E3 ubiquitin ligase Rsp5p; binds upstream of BAR1 and cell cyc  ated genes; potential Cdc28p substrate; SBF regulated [Source:SGD;Acc:S000001384]
I	YIL123W	SIM1	480	-283.5	4	Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated [Source:SGD;Acc:S000001385]
I	YIL124W	AYR1	1143	-403.4	4	NADPH-dependent 1-acyl dihydroxyacetone phosphate reductase found in lipid particles, ER, and mitochondrial outer membrane; involved in phosphatidic acid biosynthesis; required for spore germination; capable of metabolizing steroid hormones [Source:SGD;Acc:S000001386]
I	YIL125W	KGD1	2428	-1941.9	4	Component of the mitochondrial alpha-ketoglutarate dehydrogenase complex, which catalyzes a key step in the tricarboxylic acid (TCA) cycle, the oxidative decarboxylation of alpha-ketoglutarate to form succinyl-CoA [Source:SGD;Acc:S000001387]
I	YIL126W	STH1	1385	-766.1	4	ATPase component of the RSC chromatin remodeling complex; required for expression of early meiotic genes; essential helicase-related protein homologous to Snf2p [Source:SGD;Acc:S000001388]
I	YIL127C	RRT14	338	-61.5	4	Putative protein of unknown function; identified in a screen for mutants with decreased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000001389]
I	YIL128W	MET18	542	-597.3	4	DNA repair and TFIIH regulator, required for both nucleotide excision repair (NER) and RNA polymerase II (RNAP II) transcription; involved in telomere maintenance [Source:SGD;Acc:S000001390]
I	YIL129C	TAO3	611	-658.6	4	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p [Source:SGD;Acc:S000001391]
I	YIL130W	ASG1	814	-357.9	4	Zinc cluster protein proposed to function as a transcriptional regulator involved in the stress response; null mutants have a respiratory deficiency, calcofluor white sensitivity and slightly increased cycloheximide resistance [Source:SGD;Acc:S000001392]
I	YIL131C	FKH1	282	-139.4	4	Forkhead family transcription factor with a minor role in the expression of G2/M phase genes; negatively regulates transcriptional elongation; positive role in chromatin silencing at HML and HMR; regulates donor preference during switching [Source:SGD;Acc:S000001393]
I	YIL132C	CSM2	21	-55.6	4	Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; required for accurate chromosome segregation during meiosis [Source:SGD;Acc:S000001394]
I	YIL133C	RPL16A	3681	-488.7	4	N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Bp, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p [Source:SGD;Acc:S000001395]
I	YIL134C-A	YIL134C-A	13	-10.7	2	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028556]
I	YIL134W	FLX1	17	-52	2	Protein required for transport of flavin adenine dinucleotide (FAD), a synthesis product of riboflavin, across the mitochondrial membrane [Source:SGD;Acc:S000001396]
I	YIL135C	VHS2	702	-209.6	4	Cytoplasmic protein of unknown function; identified as a high-copy suppressor of the synthetic lethality of a sis2 sit4 double mutant, suggesting a role in G1/S phase progression; similar to Mlf3p [Source:SGD;Acc:S000001397]
I	YIL136W	OM45	1392	-833.7	4	Protein of unknown function, major constituent of the mitochondrial outer membrane; located on the outer (cytosolic) face of the outer membrane [Source:SGD;Acc:S000001398]
I	YIL137C	TMA108	1444	-882	4	Protein that associates with ribosomes and is involved in ribosome biogenesis; putative metalloprotease [Source:SGD;Acc:S000001399]
I	YIL138C	TPM2	1573	-340.8	4	Minor isoform of tropomyosin, binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; appears to have distinct and also overlapping functions with Tpm1p [Source:SGD;Acc:S000001400]
I	YIL139C	REV7	4	-16.1	2	Accessory subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair [Source:SGD;Acc:S000001401]
I	YIL140W	AXL2	396	-160.4	4	Integral plasma membrane protein required for axial budding in haploid cells, localizes to the incipient bud site and bud neck; glycosylated by Pmt4p; potential Cdc28p substrate [Source:SGD;Acc:S000001402]
I	YIL141W	YIL141W	3	-1.6	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001403]
I	YIL142C-A	YIL142C-A	4	-1.5	1	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028796]
I	YIL142W	CCT2	2736	-865.2	4	Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo [Source:SGD;Acc:S000001404]
I	YIL143C	SSL2	336	-221.5	4	Component of RNA polymerase transcription factor TFIIH holoenzyme; has DNA-dependent ATPase/helicase activity and is required, with Rad3p, for unwinding promoter DNA; interacts functionally with TFIIB and has roles in transcription start site select  d in gene looping to juxtapose initiation and termination regions; involved in DNA repair; homolog of human ERCC3 [Source:SGD;Acc:S000001405]
I	YIL144W	NDC80	289	-1293.7	4	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); conserved coiled-coil protein involved in chromosome segregation, spindle checkpoint activity, kinetochore assembly and clustering [Source:SGD;Acc:S000001406]
I	YIL145C	PAN6	757	-289.7	4	Pantothenate synthase, also known as pantoate-beta-alanine ligase, required for pantothenic acid biosynthesis, deletion causes pantothenic acid auxotrophy, homologous to E. coli panC [Source:SGD;Acc:S000001407]
I	YIL146C	ATG32	106	-82.1	4	Mitochondrial-anchored transmembrane receptor that interacts with the autophagy adaptor protein, Atg11p, and is essential for mitophagy, the selective vacuolar degradation of mitochondria in response to starvation [Source:SGD;Acc:S000001408]
I	YIL147C	SLN1	455	-1778	4	Histidine kinase osmosensor that regulates a MAP kinase cascade; transmembrane protein with an intracellular kinase domain that signals to Ypd1p and Ssk1p, thereby forming a phosphorelay system similar to bacterial two-component regulators [Source:SGD;Acc:S000001409]
I	YIL148W	RPL40A	4750	-555.2	4	Fusion protein, identical to Rpl40Bp, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes [Source:SGD;Acc:S000001410]
I	YIL149C	MLP2	865	-1326.2	4	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved in the Tel1p pathway that controls telomere length [Source:SGD;Acc:S000001411]
I	YIL150C	MCM10	177	-94.7	4	Essential chromatin-associated protein involved in the initiation of DNA replication; required for the association of the MCM2-7 complex with replication origins [Source:SGD;Acc:S000001412]
I	YIL151C	ESL1	194	-143.6	4	Putative protein of unknown function, predicted to contain a PINc domain [Source:SGD;Acc:S000001413]
I	YIL152W	YIL152W	4	-2.1	2	Putative protein of unknown function [Source:SGD;Acc:S000001414]
I	YIL153W	RRD1	251	-129.2	4	Peptidyl-prolyl cis/trans-isomerase; activator of the phosphotyrosyl phosphatase activity of PP2A; involved in G1 phase progression, microtubule dynamics, bud morphogenesis and DNA repair; required for rapid reduction of Sgs1p levels in response to   cin; subunit of the Tap42p-Sit4p-Rrd1p complex [Source:SGD;Acc:S000001415]
I	YIL154C	IMP2'	482	-87.4	4	IMP2', Transcriptional activator involved in maintenance of ion homeostasis and protection against DNA damage caused by bleomycin and other oxidants, contains a C-terminal leucine-rich repeat [Source:SGD;Acc:S000001416]
I	YIL155C	GUT2	1240	-1085.8	4	Mitochondrial glycerol-3-phosphate dehydrogenase; expression is repressed by both glucose and cAMP and derepressed by non-fermentable carbon sources in a Snf1p, Rsf1p, Hap2/3/4/5 complex dependent manner [Source:SGD;Acc:S000001417]
I	YIL156W	UBP7	372	-273.1	4	Ubiquitin-specific protease that cleaves ubiquitin-protein fusions [Source:SGD;Acc:S000001418]
I	YIL156W-A	YIL156W-A	3	-1.7	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028797]
I	YIL156W-B	YIL156W-B	165	-47.5	4	Putative protein of unknown function, originally identified based on homology to <i>Ashbya gossypii</i> and other related yeasts [Source:SGD;Acc:S000028511]
I	YIL157C	COA1	240	-104.6	4	Mitochondrial inner membrane protein required for assembly of the cytochrome c oxidase complex (complex IV); interacts with complex IV assembly factor Shy1p during the early stages of assembly [Source:SGD;Acc:S000001419]
I	YIL158W	AIM20	31	-32.1	4	Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000001420]
I	YIL159W	BNR1	207	-142.7	4	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNI1 [Source:SGD;Acc:S000001421]
I	YIL160C	POT1	367	-330.8	4	3-ketoacyl-CoA thiolase with broad chain length specificity, cleaves 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA during beta-oxidation of fatty acids [Source:SGD;Acc:S000001422]
I	YIL161W	YIL161W	229	-104.7	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene [Source:SGD;Acc:S000001423]
I	YIL162W	SUC2	698	-393.2	4	Invertase, sucrose hydrolyzing enzyme; a secreted, glycosylated form is regulated by glucose repression, and an intracellular, nonglycosylated enzyme is produced constitutively [Source:SGD;Acc:S000001424]
I	YIL163C	YIL163C	12	-2.1	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001425]
I	YIL164C	NIT1	14	-21.2	2	Nitrilase, member of the nitrilase branch of the nitrilase superfamily; in closely related species and other S. cerevisiae strain backgrounds YIL164C and adjacent ORF, YIL165C, likely constitute a single ORF encoding a nitrilase gene [Source:SGD;Acc:S000001426]
I	YIL165C	YIL165C	1	0	1	Putative protein of unknown function; mutant exhibits mitophagy defects; in closely related species and other S. cerevisiae strain backgrounds YIL165C and adjacent ORF, YIL164C, likely constitute a single ORF encoding a nitrilase gene [Source:SGD;Acc:S000001427]
I	YIL166C	YIL166C	15	-3.8	2	Putative protein with similarity to the allantoate permease (Dal5p) subfamily of the major facilitator superfamily; mRNA expression is elevated by sulfur limitation; YIL166C is a non-essential gene [Source:SGD;Acc:S000001428]
I	YIL169C	YIL169C	141	-126.7	4	Putative protein of unknown function; serine/threonine rich and highly similar to YOL155C, a putative glucan alpha-1,4-glucosidase; transcript is induced in both high and low pH environments; YIL169C is a non-essential gene [Source:SGD;Acc:S000001431]
I	YIL171W-A	YIL171W-A	3	-2.1	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028798]
I	YIL172C	IMA3	220	-333.3	4	Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima3p overexpression allows the ima1 null mutant to grow on isomaltose [Source:SGD;Acc:S000001434]
I	YIL173W	VTH1	559	-353.4	4	Putative membrane glycoprotein with strong similarity to Vth2p and Pep1p/Vps10p, may be involved in vacuolar protein sorting [Source:SGD;Acc:S000001435]
I	YIL176C	PAU14	2	-1.1	1	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau1p [Source:SGD;Acc:S000001438]
I	YIL177C	YIL177C	413	-366.5	4	Putative protein of unknown function; similarity to DNA helicases that are encoded within subtelomeric Y' elements and induced in telomerase deficient survivors [Source:SGD;Acc:S000001439]
I	YIL177W-A	YIL177W-A	1	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YIL177C [Source:SGD;Acc:S000028658]
I	YIR001C	SGN1	567	-132.9	4	Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation [Source:SGD;Acc:S000001440]
I	YIR002C	MPH1	204	-196.1	4	Member of the DEAH family of helicases, functions in an error-free DNA damage bypass pathway that involves homologous recombination, binds to flap DNA and stimulates activity of Rad27p and Dna2p; mutations confer a mutator phenotype [Source:SGD;Acc:S000001441]
I	YIR003W	AIM21	1177	-787.6	4	Protein of unknown function involved in mitochondrial migration along actin filament; may interact with ribosomes; GFP-fusion protein colocalizes with Sac1p to the actin cytoskeleton [Source:SGD;Acc:S000001442]
I	YIR004W	DJP1	820	-287.8	4	Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ [Source:SGD;Acc:S000001443]
I	YIR005W	IST3	85	-52.3	4	Component of the U2 snRNP, required for the first catalytic step of splicing and for spliceosomal assembly; interacts with Rds3p and is required for Mer1p-activated splicing [Source:SGD;Acc:S000001444]
I	YIR006C	PAN1	2178	-921.2	4	Part of actin cytoskeleton-regulatory complex Pan1p-Sla1p-End3p, associates with actin patches on the cell cortex; promotes protein-protein interactions essential for endocytosis; binds to and activates the Arp2/3 complex in vitro; previously though  e a subunit of poly(A) ribonuclease [Source:SGD;Acc:S000001445]
I	YIR007W	YIR007W	349	-290.9	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YIR007W is a non-essential gene [Source:SGD;Acc:S000001446]
I	YIR008C	PRI1	573	-211.6	4	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair [Source:SGD;Acc:S000001447]
I	YIR009W	MSL1	149	-62.2	4	U2B component of U2 snRNP, involved in splicing, binds the U2 snRNA stem-loop IV in vitro but requires association of Lea1p for in vivo binding; does not contain the conserved C-terminal RNA binding domain found in other family members [Source:SGD;Acc:S000001448]
I	YIR010W	DSN1	207	-148.5	4	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; important for chromosome segregation [Source:SGD;Acc:S000001449]
I	YIR011C	STS1	15	-16.2	2	Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation [Source:SGD;Acc:S000001450]
I	YIR012W	SQT1	841	-217.2	4	Essential protein involved in a late step of 60S ribosomal subunit assembly or modification; contains multiple WD repeats; interacts with Qsr1p in a two-hybrid assay [Source:SGD;Acc:S000001451]
I	YIR013C	GAT4	5	-9	2	Protein containing GATA family zinc finger motifs [Source:SGD;Acc:S000001452]
I	YIR014W	YIR014W	32	-49.6	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene [Source:SGD;Acc:S000001453]
I	YIR015W	RPR2	29	-20.1	4	Subunit of nuclear RNase P; nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; not shared between RNase MRP and RNase P, in contrast to all other RNase P protein subunits [Source:SGD;Acc:S000001454]
I	YIR016W	YIR016W	9	-9.3	2	Putative protein of unknown function; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; overexpression causes a cell cycle delay or arrest; YIR016W is a non-essential gene [Source:SGD;Acc:S000001455]
I	YIR017C	MET28	36	-44.1	4	Basic leucine zipper (bZIP) transcriptional activator in the Cbf1p-Met4p-Met28p complex, participates in the regulation of sulfur metabolism [Source:SGD;Acc:S000001456]
I	YIR017W-A	YIR017W-A	2	-2.1	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028799]
I	YIR018C-A	YIR018C-A	1	-2.5	2	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028837]
I	YIR018W	YAP5	31	-58.5	4	Basic leucine zipper (bZIP) iron-sensing transcription factor [Source:SGD;Acc:S000001457]
I	YIR019C	FLO11	20	-19.5	2	GPI-anchored cell surface glycoprotein (flocculin); required for pseudohyphal formation, invasive growth, flocculation, and biofilms; transcriptionally regulated by the MAPK pathway (via Ste12p and Tec1p) and the cAMP pathway (via Flo8p); required f   formation of fibrous interconnections between cells in a colony of a wild S. cerevisiae strain [Source:SGD;Acc:S000001458]
I	YIR020C	YIR020C	6	-2.8	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001459]
I	YIR020C-B	YIR020C-B	2	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF MRS1 [Source:SGD;Acc:S000028800]
I	YIR020W-A	YIR020W-A	5	-8.6	2	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000007241]
I	YIR021W	MRS1	211	-218.2	4	Protein required for the splicing of two mitochondrial group I introns (BI3 in COB and AI5beta in COX1); forms a splicing complex, containing four subunits of Mrs1p and two subunits of the BI3-encoded maturase, that binds to the BI3 RNA [Source:SGD;Acc:S000001460]
I	YIR021W-A	YIR021W-A	12	-3.2	2	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028838]
I	YIR022W	SEC11	673	-113.2	4	18kDa catalytic subunit of the Signal Peptidase Complex (SPC; Spc1p, Spc2p, Spc3p, and Sec11p) which cleaves the signal sequence of proteins targeted to the endoplasmic reticulum [Source:SGD;Acc:S000001461]
I	YIR023C-A	YIR023C-A	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028801]
I	YIR023W	DAL81	585	-428.4	4	Positive regulator of genes in multiple nitrogen degradation pathways; contains DNA binding domain but does not appear to bind the dodecanucleotide sequence present in the promoter region of many genes involved in allantoin catabolism [Source:SGD;Acc:S000001462]
I	YIR024C	INA22	141	-74.3	4	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; interacts with Arh1p, a mitochondrial oxidoreductase; deletion mutant has a respiratory growth defect [Source:SGD;Acc:S000001463]
I	YIR025W	MND2	63	-133.4	4	Subunit of the anaphase-promoting complex (APC); necessary for maintaining sister chromatid cohesion in prophase I of meiosis by inhibiting premature ubiquitination and subsequent degradation of substrates by the APC(Ama1) ubiquitin ligase [Source:SGD;Acc:S000001464]
I	YIR026C	YVH1	663	-943.2	4	Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases [Source:SGD;Acc:S000001465]
I	YIR027C	DAL1	51	-31.3	3	Allantoinase, converts allantoin to allantoate in the first step of allantoin degradation; expression sensitive to nitrogen catabolite repression [Source:SGD;Acc:S000001466]
I	YIR028W	DAL4	19	-9.2	2	Allantoin permease; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation [Source:SGD;Acc:S000001467]
I	YIR029W	DAL2	84	-46.7	4	Allantoicase, converts allantoate to urea and ureidoglycolate in the second step of allantoin degradation; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation [Source:SGD;Acc:S000001468]
I	YIR030C	DCG1	68	-71.4	4	Protein of unknown function, expression is sensitive to nitrogen catabolite repression and regulated by Dal80p; contains transmembrane domain [Source:SGD;Acc:S000001469]
I	YIR030W-A	YIR030W-A	5	-3.4	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028802]
I	YIR031C	DAL7	549	-550.8	4	Malate synthase, role in allantoin degradation unknown; expression sensitive to nitrogen catabolite repression and induced by allophanate, an intermediate in allantoin degradation [Source:SGD;Acc:S000001470]
I	YIR032C	DAL3	142	-73.6	4	Ureidoglycolate hydrolase, converts ureidoglycolate to glyoxylate and urea in the third step of allantoin degradation; expression sensitive to nitrogen catabolite repression [Source:SGD;Acc:S000001471]
I	YIR033W	MGA2	478	-242.6	4	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Spt23p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting [Source:SGD;Acc:S000001472]
I	YIR034C	LYS1	1386	-376.4	4	Saccharopine dehydrogenase (NAD+, L-lysine-forming), catalyzes the conversion of saccharopine to L-lysine, which is the final step in the lysine biosynthesis pathway; also has mRNA binding activity [Source:SGD;Acc:S000001473]
I	YIR035C	YIR035C	742	-191.5	4	Putative cytoplasmic protein of unknown function [Source:SGD;Acc:S000001474]
I	YIR036C	IRC24	1092	-302.6	4	Putative benzil reductase;(GFP)-fusion protein localizes to the cytoplasm and is induced by the DNA-damaging agent MMS; sequence similarity with short-chain dehydrogenase/reductases; null mutant has increased spontaneous Rad52p foci [Source:SGD;Acc:S000001475]
I	YIR036W-A	YIR036W-A	5	-2.3	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028803]
I	YIR037W	HYR1	1660	-307.4	4	Thiol peroxidase that functions as a hydroperoxide receptor to sense intracellular hydroperoxide levels and transduce a redox signal to the Yap1p transcription factor [Source:SGD;Acc:S000001476]
I	YIR038C	GTT1	1312	-264.1	4	ER associated glutathione S-transferase capable of homodimerization; expression induced during the diauxic shift and throughout stationary phase; functional overlap with Gtt2p, Grx1p, and Grx2p [Source:SGD;Acc:S000001477]
I	YIR039C	YPS6	29	-39.6	4	Putative GPI-anchored aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance [Source:SGD;Acc:S000001478]
I	YIR040C	YIR040C	6	-3	2	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000001479]
I	YIR041W	PAU15	12	-9.3	2	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions [Source:SGD;Acc:S000001480]
I	YIR042C	YIR042C	5	-2.1	2	Putative protein of unknown function; YIR042C is a non-essential gene [Source:SGD;Acc:S000001481]
J	YJL001W	PRE3	1456	-223.2	4	Beta 1 subunit of the 20S proteasome, responsible for cleavage after acidic residues in peptides [Source:SGD;Acc:S000003538]
J	YJL002C	OST1	1132	-388	4	Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins [Source:SGD;Acc:S000003539]
J	YJL003W	COX16	60	-50.9	4	Mitochondrial inner membrane protein, required for assembly of cytochrome c oxidase [Source:SGD;Acc:S000003540]
J	YJL004C	SYS1	60	-24.5	4	Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation [Source:SGD;Acc:S000003541]
J	YJL005W	CYR1	1408	-1086.6	4	Adenylate cyclase, required for cAMP production and cAMP-dependent protein kinase signaling; the cAMP pathway controls a variety of cellular processes, including metabolism, cell cycle, stress response, stationary phase, and sporulation [Source:SGD;Acc:S000003542]
J	YJL006C	CTK2	148	-326.5	4	Beta subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity [Source:SGD;Acc:S000003543]
J	YJL007C	YJL007C	4	-1.6	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003544]
J	YJL008C	CCT8	3103	-877.3	4	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo [Source:SGD;Acc:S000003545]
J	YJL009W	YJL009W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex [Source:SGD;Acc:S000003546]
J	YJL010C	NOP9	947	-350.4	4	Essential subunit of U3-containing 90S preribosome involved in production of 18S rRNA and assembly of small ribosomal subunit; also part of pre-40S ribosome and required for its export into cytoplasm; binds RNA and contains pumilio domain [Source:SGD;Acc:S000003547]
J	YJL011C	RPC17	380	-96	4	RNA polymerase III subunit C17; physically interacts with C31, C11, and TFIIIB70; may be involved in the recruitment of pol III by the preinitiation complex [Source:SGD;Acc:S000003548]
J	YJL012C	VTC4	2088	-508.1	4	Vacuolar membrane polyphosphate polymerase; subunit of the vacuolar transporter chaperone (VTC) complex involved in synthesis and transfer of polyP to the vacuole; regulates membrane trafficking; role in non-autophagic vacuolar fusion [Source:SGD;Acc:S000003549]
J	YJL013C	MAD3	115	-85	4	Subunit of the spindle-assembly checkpoint complex, which delays anaphase onset in cells with defects in mitotic spindle assembly; pseudosubstrate inhibitor of APC(Cdc20), the anaphase promoting complex involved in securin (Pds1p) turnover [Source:SGD;Acc:S000003550]
J	YJL014W	CCT3	2688	-1081.8	4	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo [Source:SGD;Acc:S000003551]
J	YJL015C	YJL015C	2	-0.1	1	Dubious open reading frame unlikely to encode a functional protein; expression if heat-inducible; located in promoter region of essential CCT3 gene encoding a subunit of the cytosolic chaperonin Cct ring complex, overlaps ORF YJL016W [Source:SGD;Acc:S000003552]
J	YJL016W	YJL016W	208	-134.8	4	Putative protein of unknown function; GFP-fusion protein localizes to the cytoplasm; conserved in closely related Saccharomyces species [Source:SGD;Acc:S000003553]
J	YJL019W	MPS3	255	-205.5	4	Nuclear envelope protein required for SPB duplication and nuclear fusion; localizes to the SPB half bridge and at telomeres during meiosis; required with Ndj1p and Csm4p for meiotic bouquet formation and telomere-led rapid prophase movement [Source:SGD;Acc:S000003556]
J	YJL020C	BBC1	2426	-1189.3	4	Protein possibly involved in assembly of actin patches; interacts with an actin assembly factor Las17p and with the SH3 domains of Type I myosins Myo3p and Myo5p; localized predominantly to cortical actin patches [Source:SGD;Acc:S000003557]
J	YJL020W-A	YJL020W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL020C/BBC1 [Source:SGD;Acc:S000028659]
J	YJL022W	YJL022W	2	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130 [Source:SGD;Acc:S000003559]
J	YJL023C	PET130	38	-56.4	4	Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003560]
J	YJL024C	APS3	391	-64.1	4	Small subunit of the clathrin-associated adaptor complex AP-3, which is involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function [Source:SGD;Acc:S000003561]
J	YJL025W	RRN7	22	-23.7	4	Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p [Source:SGD;Acc:S000003562]
J	YJL026C-A	YJL026C-A	4	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL026W/RNR2 [Source:SGD;Acc:S000028660]
J	YJL026W	RNR2	3104	-980	4	Ribonucleotide-diphosphate reductase (RNR), small subunit; the RNR complex catalyzes the rate-limiting step in dNTP synthesis and is regulated by DNA replication and DNA damage checkpoint pathways via localization of the small subunits [Source:SGD;Acc:S000003563]
J	YJL027C	YJL027C	4	-1.3	1	Putative protein of unknown function [Source:SGD;Acc:S000003564]
J	YJL028W	YJL028W	0	nf	1	Protein of unknown function; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000003565]
J	YJL029C	VPS53	413	-513.4	4	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; required for vacuolar protein sorting [Source:SGD;Acc:S000003566]
J	YJL030W	MAD2	214	-206.4	4	Component of the spindle-assembly checkpoint complex; delays the onset of anaphase in cells with defects in mitotic spindle assembly; forms a complex with Mad1p; regulates APC/C activity during prometaphase and metaphase of meiosis I [Source:SGD;Acc:S000003567]
J	YJL031C	BET4	356	-247.5	4	Alpha subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p [Source:SGD;Acc:S000003568]
J	YJL032W	YJL032W	2	-1.5	1	Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential BET4 gene encoding the alpha subunit of Type II geranylgeranyltransferase [Source:SGD;Acc:S000003569]
J	YJL033W	HCA4	1157	-345	4	Putative nucleolar DEAD box RNA helicase; high-copy number suppression of a U14 snoRNA processing mutant suggests an involvement in 18S rRNA synthesis [Source:SGD;Acc:S000003570]
J	YJL034W	KAR2	5740	-5999	4	ATPase involved in protein import into the ER, also acts as a chaperone to mediate protein folding in the ER and may play a role in ER export of soluble proteins; regulates the unfolded protein response via interaction with Ire1p [Source:SGD;Acc:S000003571]
J	YJL035C	TAD2	39	-53.5	4	Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad3p that converts adenosine to inosine at the wobble position of several tRNAs [Source:SGD;Acc:S000003572]
J	YJL036W	SNX4	665	-344.7	4	Sorting nexin, involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network and in cytoplasm to vacuole transport; contains a PX phosphoinositide-binding domain; forms complexes with Snx41p and with Atg20p [Source:SGD;Acc:S000003573]
J	YJL037W	IRC18	5	-2.9	2	Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000003574]
J	YJL038C	LOH1	5	-3.3	2	Protein of unknown function with proposed roles in maintenance of genome integrity and also in spore wall assembly; induced during sporulation; repressed during vegetative growth by Sum1p and Hst1p; sequence similar to IRC1 [Source:SGD;Acc:S000003575]
J	YJL039C	NUP192	1087	-2020.7	4	Essential structural subunit of the nuclear pore complex (NPC), localizes to the nuclear periphery of nuclear pores, homologous to human p205 [Source:SGD;Acc:S000003576]
J	YJL041W	NSP1	2357	-1401.1	4	Essential component of the nuclear pore complex, which mediates nuclear import and export, found in both the Nup82 and Nic96 complexes [Source:SGD;Acc:S000003577]
J	YJL042W	MHP1	1284	-789.3	4	Microtubule-associated protein involved in assembly and stabilization of microtubules; overproduction results in cell cycle arrest at G2 phase; similar to Drosophila protein MAP and to mammalian MAP4 proteins [Source:SGD;Acc:S000003578]
J	YJL043W	YJL043W	8	-1.5	1	Putative protein of unknown function; YJL043W is a non-essential gene [Source:SGD;Acc:S000003579]
J	YJL044C	GYP6	294	-205.5	4	GTPase-activating protein (GAP) for the yeast Rab family member, Ypt6p; involved in vesicle mediated protein transport [Source:SGD;Acc:S000003580]
J	YJL045W	YJL045W	1140	-447	4	Minor succinate dehydrogenase isozyme; homologous to Sdh1p, the major isozyme reponsible for the oxidation of succinate and transfer of electrons to ubiquinone; induced during the diauxic shift in a Cat8p-dependent manner [Source:SGD;Acc:S000003581]
J	YJL046W	AIM22	173	-194.7	4	Putative lipoate-protein ligase, required along with Lip2 and Lip5 for lipoylation of Lat1p and Kgd2p; similar to E. coli LplA; null mutant displays reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000003582]
J	YJL047C	RTT101	223	-244.9	4	Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p [Source:SGD;Acc:S000003583]
J	YJL047C-A	YJL047C-A	4	-1.1	1	Putative protein of unknown function [Source:SGD;Acc:S000028804]
J	YJL048C	UBX6	93	-211.8	4	UBX (ubiquitin regulatory X) domain-containing protein that interacts with Cdc48p, transcription is repressed when cells are grown in media containing inositol and choline [Source:SGD;Acc:S000003584]
J	YJL049W	YJL049W	195	-216	4	Putative protein of unknown function; YJL049W is a non-essential gene [Source:SGD;Acc:S000003585]
J	YJL050W	MTR4	1886	-732.5	4	ATP-dependent 3'-5' RNA helicase of the Dead-box family, involved in nuclear RNA processing and degradation both as a component of the TRAMP complex and in TRAMP independent processes; has a KOW domain that shows RNA binding activity [Source:SGD;Acc:S000003586]
J	YJL051W	IRC8	151	-60.5	4	Bud tip localized protein of unknown function; mRNA is targeted to the bud by a She2p dependent transport system; mRNA is cell cycle regulated via Fkh2p, peaking in G2/M phase; null mutant displays increased levels of spontaneous Rad52p foc [Source:SGD;Acc:S000003587]
J	YJL052C-A	YJL052C-A	0	nf	1	Putative protein of unknown function, identified based on comparison to related yeast species [Source:SGD;Acc:S000007610]
J	YJL052W	TDH1	7140	-2838	4	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 1, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall [Source:SGD;Acc:S000003588]
J	YJL053W	PEP8	549	-242.1	4	Vacuolar protein sorting protein that forms part of the multimeric membrane-associated retromer complex along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport [Source:SGD;Acc:S000003589]
J	YJL054W	TIM54	588	-554.9	4	Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane [Source:SGD;Acc:S000003590]
J	YJL055W	YJL055W	1195	-249.1	4	Putative protein of unknown function, proposed to be involved in the metabolism of purine and pyrimidine base analogues; deletion mutants are sensitive to HAP and AHA; overexpression confers resistance to 5-FOA and 5-FU [Source:SGD;Acc:S000003591]
J	YJL056C	ZAP1	153	-169.8	4	Zinc-regulated transcription factor; binds to zinc-responsive promoters to induce transcription of certain genes in presence of zinc, represses other genes in low zinc; regulates its own transcription; contains seven zinc-finger domains [Source:SGD;Acc:S000003592]
J	YJL057C	IKS1	167	-487.1	4	Putative serine/threonine kinase; expression is induced during mild heat stress; deletion mutants are hypersensitive to copper sulphate and resistant to sorbate; interacts with an N-terminal fragment of Sst2p [Source:SGD;Acc:S000003593]
J	YJL058C	BIT61	103	-65.2	4	Subunit of TORC2 (Tor2p-Lst8p-Avo1-Avo2-Tsc11p-Bit61p-Slm1p-Slm2p), a membrane-associated complex that regulates cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity [Source:SGD;Acc:S000003594]
J	YJL059W	YHC3	13	-13.8	3	Vacuolar membrane protein involved in the ATP-dependent transport of arginine into the vacuole and possibly in balancing ion homeostasis; homolog of human CLN3 involved in Batten disease (juvenile onset neuronal ceroid lipofuscinosis) [Source:SGD;Acc:S000003595]
J	YJL060W	BNA3	1102	-286.3	4	Kynurenine aminotransferase, catalyzes formation of kynurenic acid from kynurenine; potential Cdc28p substrate [Source:SGD;Acc:S000003596]
J	YJL061W	NUP82	807	-778.2	4	Nucleoporin, subunit of the nuclear pore complex (NPC); forms a subcomplex with Gle2p, Nup159p, Nsp1p, and Nup116p and is required for proper localization of Nup116p in the NPC [Source:SGD;Acc:S000003597]
J	YJL062W	LAS21	147	-102.4	4	Integral plasma membrane protein involved in the synthesis of the glycosylphosphatidylinositol (GPI) core structure; mutations affect cell wall integrity [Source:SGD;Acc:S000003598]
J	YJL062W-A	COA3	135	-38.2	4	Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly [Source:SGD;Acc:S000007611]
J	YJL063C	MRPL8	470	-190.7	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000003599]
J	YJL064W	YJL064W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL065C/DLS1 [Source:SGD;Acc:S000003600]
J	YJL065C	DLS1	139	-51.2	4	Subunit of ISW2/yCHRAC chromatin accessibility complex along with Itc1p, Isw2p, and Dpb4p; involved in inheritance of telomeric silencing [Source:SGD;Acc:S000003601]
J	YJL066C	MPM1	883	-238.1	4	Mitochondrial membrane protein of unknown function, contains no hydrophobic stretches [Source:SGD;Acc:S000003602]
J	YJL067W	YJL067W	2	-2.6	2	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003603]
J	YJL068C	YJL068C	1188	-251.7	4	Non-essential intracellular esterase that can function as an S-formylglutathione hydrolase; may be involved in the detoxification of formaldehyde, which can be metabolized to S-formylglutathione; similar to human esterase D [Source:SGD;Acc:S000003604]
J	YJL069C	UTP18	833	-201.9	4	Possible U3 snoRNP protein involved in maturation of pre-18S rRNA, based on computational analysis of large-scale protein-protein interaction data [Source:SGD;Acc:S000003605]
J	YJL070C	YJL070C	555	-310.6	4	Putative protein of unknown function with similarity to AMP deaminases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YJL070C is a non-essential gene [Source:SGD;Acc:S000003606]
J	YJL071W	ARG2	188	-132.5	4	Acetylglutamate synthase (glutamate N-acetyltransferase), mitochondrial enzyme that catalyzes the first step in the biosynthesis of the arginine precursor ornithine; forms a complex with Arg5,6p [Source:SGD;Acc:S000003607]
J	YJL072C	PSF2	154	-74.3	4	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery [Source:SGD;Acc:S000003608]
J	YJL073W	JEM1	285	-229.7	4	DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2 [Source:SGD;Acc:S000003609]
J	YJL074C	SMC3	915	-741.6	4	Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member [Source:SGD;Acc:S000003610]
J	YJL075C	APQ13	0	nf	1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene NET1; null mutant is sensitive to sorbate [Source:SGD;Acc:S000003611]
J	YJL076W	NET1	2222	-1900	4	Core subunit of the RENT complex, which is a complex involved in nucleolar silencing and telophase exit; stimulates transcription by RNA polymerase I and regulates nucleolar structure [Source:SGD;Acc:S000003612]
J	YJL077C	ICS3	7	-3	2	Protein of unknown function; may play a role in vacuolar sorting, null mutants are hypersensitive to sortin2 [Source:SGD;Acc:S000003613]
J	YJL077W-A	YJL077W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL077C/ICS3 [Source:SGD;Acc:S000028661]
J	YJL077W-B	YJL077W-B	2	-1.5	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028662]
J	YJL078C	PRY3	87	-36.6	4	Cell wall protein with a role in mating efficiency; expression of full-length transcript is daughter cell-specific; in response to alpha factor, a short transcript starting at +452 is expressed and the long form is repressed by Ste12p [Source:SGD;Acc:S000003614]
J	YJL079C	PRY1	99	-43.1	3	Protein of unknown function [Source:SGD;Acc:S000003615]
J	YJL080C	SCP160	3797	-2248	4	Essential RNA-binding G protein effector of mating response pathway, mainly associated with nuclear envelope and ER, interacts in mRNA-dependent manner with translating ribosomes via multiple KH domains, similar to vertebrate vigilins [Source:SGD;Acc:S000003616]
J	YJL081C	ARP4	912	-1388.8	4	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes [Source:SGD;Acc:S000003617]
J	YJL082W	IML2	866	-518	4	Protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003618]
J	YJL083W	TAX4	145	-196.6	4	EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS [Source:SGD;Acc:S000003619]
J	YJL084C	ALY2	849	-427.5	4	Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; phosphorylated by Npr1p and also by cyclin-CDK complex Pcl7p-Pho85p; promotes endocytosis of plasma membrane proteins [Source:SGD;Acc:S000003620]
J	YJL085W	EXO70	468	-442.3	4	Subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which directs secretory vesicles to active sites of exocytosis; acts with Sec3p in membrane targeting of the exocyst via PI(4,5)P2 binding [Source:SGD;Acc:S000003621]
J	YJL086C	YJL086C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL085W/EXO70 and YJL087C/TRL1 [Source:SGD;Acc:S000003622]
J	YJL087C	TRL1	959	-416	4	tRNA ligase, required for tRNA splicing and for both splicing and translation of HAC1 mRNA in the UPR; has phosphodiesterase, polynucleotide kinase, and ligase activities; localized at the inner nuclear envelope and partially to polysomes [Source:SGD;Acc:S000003623]
J	YJL088W	ARG3	707	-416.4	4	Ornithine carbamoyltransferase (carbamoylphosphate:L-ornithine carbamoyltransferase), catalyzes the sixth step in the biosynthesis of the arginine precursor ornithine [Source:SGD;Acc:S000003624]
J	YJL089W	SIP4	54	-62.3	4	C6 zinc cluster transcriptional activator that binds to the carbon source-responsive element (CSRE) of gluconeogenic genes; involved in the positive regulation of gluconeogenesis; regulated by Snf1p protein kinase; localized to the nucleus [Source:SGD;Acc:S000003625]
J	YJL090C	DPB11	78	-74.5	4	Replication initiation protein that loads DNA pol epsilon onto pre-replication complexes at origins; checkpoint sensor recruited to stalled replication forks by the checkpoint clamp complex where it activates Mec1p; ortholog of human TopBP1 [Source:SGD;Acc:S000003626]
J	YJL091C	GWT1	66	-54.4	4	Protein involved in the inositol acylation of glucosaminyl phosphatidylinositol (GlcN-PI) to form glucosaminyl(acyl)phosphatidylinositol (GlcN(acyl)PI), an intermediate in the biosynthesis of glycosylphosphatidylinositol (GPI) anchors [Source:SGD;Acc:S000003627]
J	YJL092W	SRS2	179	-148.5	4	DNA helicase and DNA-dependent ATPase involved in DNA repair, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability [Source:SGD;Acc:S000003628]
J	YJL093C	TOK1	13	-11.6	2	Outward-rectifier potassium channel of the plasma membrane with two pore domains in tandem, each of which forms a functional channel permeable to potassium; carboxy tail functions to prevent inner gate closures; target of K1 toxin [Source:SGD;Acc:S000003629]
J	YJL094C	KHA1	157	-102.4	4	Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003630]
J	YJL095W	BCK1	590	-2412.6	4	Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p [Source:SGD;Acc:S000003631]
J	YJL096W	MRPL49	417	-122.1	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000003632]
J	YJL097W	PHS1	203	-54.2	4	Essential 3-hydroxyacyl-CoA dehydratase of the ER membrane, involved in elongation of very long-chain fatty acids; evolutionarily conserved, similar to mammalian PTPLA and PTPLB; involved in sphingolipid biosynthesis and protein trafficking [Source:SGD;Acc:S000003633]
J	YJL098W	SAP185	526	-2081.6	4	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap190p [Source:SGD;Acc:S000003634]
J	YJL099W	CHS6	216	-228.3	4	Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane [Source:SGD;Acc:S000003635]
J	YJL100W	LSB6	93	-253.1	4	Type II phosphatidylinositol 4-kinase that binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization [Source:SGD;Acc:S000003636]
J	YJL101C	GSH1	782	-315.9	4	Gamma glutamylcysteine synthetase catalyzes the first step in glutathione (GSH) biosynthesis; expression induced by oxidants, cadmium, and mercury [Source:SGD;Acc:S000003637]
J	YJL102W	MEF2	264	-296.7	4	Mitochondrial elongation factor involved in translational elongation [Source:SGD;Acc:S000003638]
J	YJL103C	GSM1	80	-157.8	4	Putative zinc cluster protein of unknown function; proposed to be involved in the regulation of energy metabolism, based on patterns of expression and sequence analysis [Source:SGD;Acc:S000003639]
J	YJL104W	PAM16	646	-153.8	4	Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain [Source:SGD;Acc:S000003640]
J	YJL105W	SET4	14	-10.1	2	Protein of unknown function, contains a SET domain [Source:SGD;Acc:S000003641]
J	YJL106W	IME2	83	-934.4	4	Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p [Source:SGD;Acc:S000003642]
J	YJL107C	YJL107C	17	-13	2	Putative protein of unknown function; expression is induced by activation of the HOG1 mitogen-activated signaling pathway and this induction is Hog1p/Pbs2p dependent; YJL107C and adjacent ORF, YJL108C are merged in related fungi [Source:SGD;Acc:S000003643]
J	YJL108C	PRM10	5	-1.6	1	Pheromone-regulated protein, proposed to be involved in mating; predicted to have 5 transmembrane segments; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000003644]
J	YJL109C	UTP10	1805	-1073.4	4	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000003645]
J	YJL110C	GZF3	250	-83.5	4	GATA zinc finger protein and Dal80p homolog that negatively regulates nitrogen catabolic gene expression by competing with Gat1p for GATA site binding; function requires a repressive carbon source; dimerizes with Dal80p and binds to Tor1p [Source:SGD;Acc:S000003646]
J	YJL111W	CCT7	2573	-811.5	4	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000003647]
J	YJL112W	MDV1	481	-481.3	4	Peripheral protein of the cytosolic face of the mitochondrial outer membrane, required for mitochondrial fission; interacts with Fis1p and with the dynamin-related GTPase Dnm1p; contains WD repeats [Source:SGD;Acc:S000003648]
J	YJL113W	YJL113W	41	-27.7	3	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000003649]
J	YJL114W	YJL114W	61	-4.2	2	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000003650]
J	YJL115W	ASF1	833	-173.6	4	Nucleosome assembly factor, involved in chromatin assembly and disassembly, anti-silencing protein that causes derepression of silent loci when overexpressed; plays a role in regulating Ty1 transposition [Source:SGD;Acc:S000003651]
J	YJL116C	NCA3	138	-43.4	4	Protein that functions with Nca2p to regulate mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p ) of the Fo-F1 ATP synthase; member of the SUN family; expression induced in cells treated with the mycotoxin patulin [Source:SGD;Acc:S000003652]
J	YJL117W	PHO86	1128	-203.9	4	Endoplasmic reticulum (ER) resident protein required for ER exit of the high-affinity phosphate transporter Pho84p, specifically required for packaging of Pho84p into COPII vesicles [Source:SGD;Acc:S000003653]
J	YJL118W	YJL118W	6	-10	2	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; YJL18W is a non-essential gene; deletion enhances the toxicity of heterologously expressed human alpha-synuclein [Source:SGD;Acc:S000003654]
J	YJL119C	YJL119C	6	-2.8	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003655]
J	YJL120W	YJL120W	9	-3.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL121C/RPE1; deletion confers sensitivity to GSAO [Source:SGD;Acc:S000003656]
J	YJL121C	RPE1	1168	-5999	4	D-ribulose-5-phosphate 3-epimerase, catalyzes a reaction in the non-oxidative part of the pentose-phosphate pathway; mutants are sensitive to oxidative stress [Source:SGD;Acc:S000003657]
J	YJL122W	ALB1	606	-157.8	4	Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit; interacts directly with Arx1p; responsible for Tif6p recycling defects in absence of Rei1p [Source:SGD;Acc:S000003658]
J	YJL123C	MTC1	2194	-363.7	4	Protein of unknown function that may interact with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to COPI-coated vesicles (early Golgi); mtc1 is synthetically lethal with cdc13-1 [Source:SGD;Acc:S000003659]
J	YJL124C	LSM1	757	-583.7	4	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs [Source:SGD;Acc:S000003660]
J	YJL125C	GCD14	527	-218.1	4	Subunit of tRNA (1-methyladenosine) methyltransferase, with Gcd10p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression [Source:SGD;Acc:S000003661]
J	YJL126W	NIT2	165	-117.2	4	Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member [Source:SGD;Acc:S000003662]
J	YJL127C	SPT10	69	-129.3	4	Putative histone acetylase with a role in transcriptional silencing, sequence-specific activator of histone genes, binds specifically and cooperatively to pairs of UAS elements in core histone promoters, functions at or near the TATA box [Source:SGD;Acc:S000003663]
J	YJL127C-B	YJL127C-B	27	-16.6	4	Putative protein of unknown function; identified based on homology to the filamentous fungus, <i>Ashbya gossypii</i> [Source:SGD;Acc:S000028522]
J	YJL127W-A	YJL127W-A	9	-2.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007612]
J	YJL128C	PBS2	1018	-898.9	4	MAP kinase kinase of the HOG signaling pathway; activated under severe osmotic stress; mitophagy-specific regulator; plays a role in regulating Ty1 transposition [Source:SGD;Acc:S000003664]
J	YJL129C	TRK1	164	-101.6	4	Component of the Trk1p-Trk2p potassium transport system; 180 kDa high affinity potassium transporter; phosphorylated in vivo and interacts physically with the phosphatase Ppz1p, suggesting Trk1p acitivy is regulated by phosphorylation [Source:SGD;Acc:S000003665]
J	YJL130C	URA2	4480	-4769.9	4	Bifunctional carbamoylphosphate synthetase (CPSase)-aspartate transcarbamylase (ATCase), catalyzes the first two enzymatic steps in the de novo biosynthesis of pyrimidines; both activities are subject to feedback inhibition by UTP [Source:SGD;Acc:S000003666]
J	YJL131C	AIM23	205	-181.5	4	Putative protein of unknown function; the authentic non-tagged protein is detected in highly purified mitochondria; null mutant is viable, displays severe respiratory growth defect and elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000003667]
J	YJL132W	YJL132W	75	-193.2	4	Putative protein of unknown function; localizes to the membrane fraction; possible Zap1p-regulated target gene induced by zinc deficiency; YJL132W is a non-essential gene [Source:SGD;Acc:S000003668]
J	YJL133C-A	YJL133C-A	318	-94	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000028805]
J	YJL133W	MRS3	107	-112.2	4	Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs4p; active under low-iron conditions; may transport other cations [Source:SGD;Acc:S000003669]
J	YJL134W	LCB3	317	-60.6	4	Long-chain base-1-phosphate phosphatase with specificity for dihydrosphingosine-1-phosphate, regulates ceramide and long-chain base phosphates levels, involved in incorporation of exogenous long chain bases in sphingolipids [Source:SGD;Acc:S000003670]
J	YJL135W	YJL135W	3	-10.9	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified genes YJL134W/LCB3 [Source:SGD;Acc:S000003671]
J	YJL136C	RPS21B	3576	-273.7	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Ap and has similarity to rat S21 ribosomal protein [Source:SGD;Acc:S000003672]
J	YJL136W-A	YJL136W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by SAGE [Source:SGD;Acc:S000028806]
J	YJL137C	GLG2	139	-179.3	4	Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin [Source:SGD;Acc:S000003673]
J	YJL138C	TIF2	4901	-1563.8	4	Translation initiation factor eIF4A, identical to Tif1p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G [Source:SGD;Acc:S000003674]
J	YJL139C	YUR1	78	-146.7	4	Mannosyltransferase of the KTR1 family, involved in protein N-glycosylation; located in the Golgi apparatus [Source:SGD;Acc:S000003675]
J	YJL140W	RPB4	949	-254	4	RNA polymerase II subunit B32; forms two subunit dissociable complex with Rpb7p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved  anslation initiation [Source:SGD;Acc:S000003676]
J	YJL141C	YAK1	660	-3019.6	4	Serine-threonine protein kinase; component of a glucose-sensing system that inhibits growth in response to glucose availability; upon nutrient deprivation Yak1p phosphorylates Pop2p to regulate mRNA deadenylation, the co-repressor Crf1p to inhibit t  iption of ribosomal genes, and the stress-responsive transcription factors Hsf1p and Msn2p; nuclear localization negatively regulated by the Ras/PKA signaling pathway in the presence of glucose [Source:SGD;Acc:S000003677]
J	YJL142C	IRC9	3	-11.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YJL141C; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000003678]
J	YJL143W	TIM17	262	-118.9	4	Essential subunit of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); with Tim23p, contributes to the architecture and function of the import channel; may link the import motor to the core TIM23 complex [Source:SGD;Acc:S000003679]
J	YJL144W	YJL144W	3	-7.3	2	Cytoplasmic hydrophilin with a role in dessication resistance; expression induced by osmotic stress, starvation and during stationary phase; GFP-fusion protein is induced by the DNA-damaging agent MMS [Source:SGD;Acc:S000003680]
J	YJL145W	SFH5	848	-355.1	4	Non-classical phosphatidylinositol transfer protein (PITP); exhibits PI- but not PC-transfer activity; localizes to the peripheral endoplasmic reticulum, cytosol and microsomes; similar to Sec14p [Source:SGD;Acc:S000003681]
J	YJL146W	IDS2	434	-272.9	4	Protein involved in modulation of Ime2p activity during meiosis, appears to act indirectly to promote Ime2p-mediated late meiotic functions; found in growing cells and degraded during sporulation [Source:SGD;Acc:S000003682]
J	YJL147C	YJL147C	27	-140.9	4	Mitochondrial protein of unknown function; homozygous diploid deletion strain has a sporulation defect characterized by elevated dityrosine in the soluble fraction; expression induced by calcium shortage; YJL147W is a non-essential gene [Source:SGD;Acc:S000003683]
J	YJL148W	RPA34	950	-172.4	4	RNA polymerase I subunit A34.5 [Source:SGD;Acc:S000003684]
J	YJL149W	DAS1	247	-234.3	4	Putative SCF ubiquitin ligase F-box protein; interacts physically with both Cdc53p and Skp1 and genetically with CDC34; similar to putative F-box protein YDR131C [Source:SGD;Acc:S000003685]
J	YJL150W	YJL150W	1	-1.5	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003686]
J	YJL151C	SNA3	174	-179	4	Integral membrane protein localized to vacuolar intralumenal vesicles, computational analysis of large-scale protein-protein interaction data suggests a possible role in either cell wall synthesis or protein-vacuolar targeting [Source:SGD;Acc:S000003687]
J	YJL152W	YJL152W	1	-1.3	1	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003688]
J	YJL153C	INO1	1072	-1289.8	4	Inositol-3-phosphate synthase, involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element [Source:SGD;Acc:S000003689]
J	YJL154C	VPS35	739	-515.4	4	Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval [Source:SGD;Acc:S000003690]
J	YJL155C	FBP26	526	-391.7	4	Fructose-2,6-bisphosphatase, required for glucose metabolism [Source:SGD;Acc:S000003691]
J	YJL156C	SSY5	113	-44	4	Serine protease of SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p); contains an inhibitory domain that dissociates in response to extracellular amino acids, freeing a catalytic domain to activate transcription factor Stp1p [Source:SGD;Acc:S000003692]
J	YJL156W-A	YJL156W-A	1	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007613]
J	YJL157C	FAR1	217	-2917.5	4	Cyclin-dependent kinase inhibitor that mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate [Source:SGD;Acc:S000003693]
J	YJL158C	CIS3	934	-123.9	4	Mannose-containing glycoprotein constituent of the cell wall; member of the PIR (proteins with internal repeats) family [Source:SGD;Acc:S000003694]
J	YJL159W	HSP150	1234	-202.4	4	O-mannosylated heat shock protein that is secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation [Source:SGD;Acc:S000003695]
J	YJL160C	YJL160C	685	-50.5	4	Putative protein of unknown function; member of the PIR (proteins with internal repeats) family of cell wall proteins; non-essential gene that is required for sporulation; mRNA is weakly cell cycle regulated, peaking in mitosis [Source:SGD;Acc:S000003696]
J	YJL161W	FMP33	74	-71.6	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003697]
J	YJL162C	JJJ2	177	-136.8	4	Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein [Source:SGD;Acc:S000003698]
J	YJL163C	YJL163C	25	-24.8	2	Putative protein of unknown function [Source:SGD;Acc:S000003699]
J	YJL164C	TPK1	640	-485.7	4	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; inhibited by regulatory subunit Bcy1p in the absence of cAMP; partially redundant with Tpk2p and Tpk3p [Source:SGD;Acc:S000003700]
J	YJL165C	HAL5	1050	-368.9	4	Putative protein kinase; overexpression increases sodium and lithium tolerance, whereas gene disruption increases cation and low pH sensitivity and impairs potassium uptake, suggesting a role in regulation of Trk1p and/or Trk2p transporters [Source:SGD;Acc:S000003701]
J	YJL166W	QCR8	448	-116.8	4	Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p [Source:SGD;Acc:S000003702]
J	YJL167W	ERG20	2864	-907.9	4	Farnesyl pyrophosphate synthetase, has both dimethylallyltranstransferase and geranyltranstransferase activities; catalyzes the formation of C15 farnesyl pyrophosphate units for isoprenoid and sterol biosynthesis [Source:SGD;Acc:S000003703]
J	YJL168C	SET2	790	-313.9	4	Histone methyltransferase with a role in transcriptional elongation, methylates a lysine residue of histone H3; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p [Source:SGD;Acc:S000003704]
J	YJL169W	YJL169W	4	-2.6	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL168C/SET2 [Source:SGD;Acc:S000003705]
J	YJL170C	ASG7	51	-24.7	4	Protein that regulates signaling from a G protein beta subunit Ste4p and its relocalization within the cell; specific to a-cells and induced by alpha-factor [Source:SGD;Acc:S000003706]
J	YJL171C	YJL171C	1098	-211.6	4	GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein [Source:SGD;Acc:S000003707]
J	YJL172W	CPS1	2103	-425.1	4	Vacuolar carboxypeptidase yscS; expression is induced under low-nitrogen conditions [Source:SGD;Acc:S000003708]
J	YJL173C	RFA3	1174	-110.6	4	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination [Source:SGD;Acc:S000003709]
J	YJL174W	KRE9	254	-60.1	4	Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects [Source:SGD;Acc:S000003710]
J	YJL175W	YJL175W	2	-9.9	2	Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor [Source:SGD;Acc:S000003711]
J	YJL176C	SWI3	998	-647.4	4	Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2 [Source:SGD;Acc:S000003712]
J	YJL177W	RPL17B	4347	-828	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Ap and has similarity to E. coli L22 and rat L17 ribosomal proteins [Source:SGD;Acc:S000003713]
J	YJL178C	ATG27	833	-187.9	4	Type I membrane protein involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; may be involved in membrane delivery to the phagophore assembly site [Source:SGD;Acc:S000003714]
J	YJL179W	PFD1	519	-136.7	4	Subunit of heterohexameric prefoldin, which binds cytosolic chaperonin and transfers target proteins to it; involved in the biogenesis of actin and of alpha- and gamma-tubulin [Source:SGD;Acc:S000003715]
J	YJL180C	ATP12	457	-266.6	4	Conserved protein required for assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase; mutation of human ATP12 reduces active ATP synthase levels and is associated with the disorder ATPAF2 deficiency [Source:SGD;Acc:S000003716]
J	YJL181W	YJL181W	16	-7.2	2	Putative protein of unknown function; expression is cell-cycle regulated as shown by microarray analysis; potential regulatory target of Mbp1p, which binds to the YJL181W promoter region [Source:SGD;Acc:S000003717]
J	YJL182C	YJL182C	1	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized ORF YJL181W [Source:SGD;Acc:S000003718]
J	YJL183W	MNN11	1200	-300.2	4	Subunit of a Golgi mannosyltransferase complex that also contains Anp1p, Mnn9p, Mnn10p, and Hoc1p, and mediates elongation of the polysaccharide mannan backbone; has homology to Mnn10p [Source:SGD;Acc:S000003719]
J	YJL184W	GON7	630	-141.1	4	Component of the EKC/KEOPS protein complex with Kae1p, Cgi121p, Pcc1p, and Bud32p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; implicated in osmotic stress response [Source:SGD;Acc:S000003720]
J	YJL185C	ATG36	19	-45.5	4	Putative protein of unknown function; mRNA is weakly cell cycle regulated, peaking in G2 phase; YJL185C is a non-essential gene [Source:SGD;Acc:S000003721]
J	YJL186W	MNN5	1122	-456.4	4	Alpha-1,2-mannosyltransferase, responsible for addition of the second alpha-1,2-linked mannose of the branches on the mannan backbone of oligosaccharides, localizes to an early Golgi compartment [Source:SGD;Acc:S000003722]
J	YJL187C	SWE1	138	-2638.8	4	Protein kinase that regulates the G2/M transition by inhibition of Cdc28p kinase activity; localizes to the nucleus and to the daughter side of the mother-bud neck; homolog of S. pombe Wee1p; potential Cdc28p substrate [Source:SGD;Acc:S000003723]
J	YJL188C	BUD19	87	-4.3	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay [Source:SGD;Acc:S000003724]
J	YJL189W	RPL39	1230	-65.2	4	Protein component of the large (60S) ribosomal subunit, has similarity to rat L39 ribosomal protein; required for ribosome biogenesis; loss of both Rpl31p and Rpl39p confers lethality; also exhibits genetic interactions with SIS1 and PAB1 [Source:SGD;Acc:S000003725]
J	YJL190C	RPS22A	4168	-653.3	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Bp and has similarity to E. coli S8 and rat S15a ribosomal proteins [Source:SGD;Acc:S000003726]
J	YJL191W	RPS14B	4951	-621.6	4	Ribosomal protein 59 of the small subunit, required for ribosome assembly and 20S pre-rRNA processing; mutations confer cryptopleurine resistance; nearly identical to Rps14Ap and similar to E. coli S11 and rat S14 ribosomal proteins [Source:SGD;Acc:S000003727]
J	YJL192C	SOP4	400	-95.7	4	ER-membrane protein; suppressor of pma1-7, deletion of SOP4 slows down the export of wild-type Pma1p and Pma1-7 from the ER [Source:SGD;Acc:S000003728]
J	YJL193W	YJL193W	133	-56.7	4	Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect [Source:SGD;Acc:S000003729]
J	YJL194W	CDC6	58	-17.8	2	Essential ATP-binding protein required for DNA replication, component of the pre-replicative complex (pre-RC) which requires ORC to associate with chromatin and is in turn required for Mcm2-7p DNA association; homologous to S. pombe Cdc18p [Source:SGD;Acc:S000003730]
J	YJL195C	YJL195C	7	-7.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL194W/CDC6 [Source:SGD;Acc:S000003731]
J	YJL196C	ELO1	235	-64.9	4	Elongase I, medium-chain acyl elongase, catalyzes carboxy-terminal elongation of unsaturated C12-C16 fatty acyl-CoAs to C16-C18 fatty acids [Source:SGD;Acc:S000003732]
J	YJL197C-A	YJL197C-A	1	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene YJL197C/UBP12 [Source:SGD;Acc:S000028839]
J	YJL197W	UBP12	696	-621.7	4	Ubiquitin carboxyl-terminal hydrolase, ubiquitin-specific protease present in the nucleus and cytoplasm that cleaves ubiquitin from ubiquitinated proteins [Source:SGD;Acc:S000003733]
J	YJL198W	PHO90	260	-128.6	4	Low-affinity phosphate transporter; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth [Source:SGD;Acc:S000003734]
J	YJL199C	MBB1	19	-20.1	3	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; protein detected in large-scale protein-protein interaction studies [Source:SGD;Acc:S000003735]
J	YJL200C	ACO2	1849	-968.1	4	Putative mitochondrial aconitase isozyme; similarity to Aco1p, an aconitase required for the TCA cycle; expression induced during growth on glucose, by amino acid starvation via Gcn4p, and repressed on ethanol [Source:SGD;Acc:S000003736]
J	YJL201W	ECM25	464	-195.1	4	Non-essential protein of unknown function; promoter contains a consensus binding sequence for factor Abf1p [Source:SGD;Acc:S000003737]
J	YJL202C	YJL202C	1	0	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 3' end of essential PRP21 gene encoding a subunit of the SF3a splicing factor complex [Source:SGD;Acc:S000003738]
J	YJL203W	PRP21	229	-217.8	4	Subunit of the SF3a splicing factor complex, required for spliceosome assembly [Source:SGD;Acc:S000003739]
J	YJL204C	RCY1	341	-423.1	4	F-box protein involved in recycling plasma membrane proteins internalized by endocytosis; localized to sites of polarized growth [Source:SGD;Acc:S000003740]
J	YJL205C	NCE101	14	-22.2	2	Protein of unknown function, involved in secretion of proteins that lack classical secretory signal sequences [Source:SGD;Acc:S000003742]
J	YJL206C	YJL206C	73	-92.5	4	Putative protein of unknown function; similar to transcriptional regulators from the Zn[2]-Cys[6] binuclear cluster protein family; mRNA is weakly cell cycle regulated, peaking in S phase; induced rapidly upon MMS treatment [Source:SGD;Acc:S000003741]
J	YJL207C	LAA1	676	-750.6	4	AP-1 accessory protein; colocalizes with clathrin to the late-Golgi apparatus; involved in TGN-endosome transport; physically interacts with AP-1; similar to the mammalian p200; may interact with ribosomes; YJL207C is a non-essential gene [Source:SGD;Acc:S000003743]
J	YJL208C	NUC1	644	-276.9	4	Major mitochondrial nuclease, has RNAse and DNA endo- and exonucleolytic activities; has roles in mitochondrial recombination, apoptosis and maintenance of polyploidy [Source:SGD;Acc:S000003744]
J	YJL209W	CBP1	56	-142.3	4	Mitochondrial protein that interacts with the 5'-untranslated region of the COB mRNA and has a role in its stability and translation; found in a complex at the inner membrane along with Pet309p [Source:SGD;Acc:S000003745]
J	YJL210W	PEX2	119	-81.5	4	RING-finger peroxin and E3 ubiquitin ligase, peroxisomal membrane protein with a C-terminal zinc-binding RING domain, forms translocation subcomplex with Pex10p and Pex12p which functions in peroxisomal matrix protein import [Source:SGD;Acc:S000003746]
J	YJL211C	YJL211C	2	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL210W/PEX2 [Source:SGD;Acc:S000003747]
J	YJL212C	OPT1	139	-62	4	Proton-coupled oligopeptide transporter of the plasma membrane; also transports glutathione and phytochelatin; member of the OPT family [Source:SGD;Acc:S000003748]
J	YJL213W	YJL213W	44	-57.8	4	Protein of unknown function that may interact with ribosomes; periodically expressed during the yeast metabolic cycle; phosphorylated in vitro by the mitotic exit network (MEN) kinase complex, Dbf2p/Mob1p [Source:SGD;Acc:S000003749]
J	YJL214W	HXT8	129	-22.1	3	Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose [Source:SGD;Acc:S000003750]
J	YJL215C	YJL215C	2	-2.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003751]
J	YJL216C	IMA5	108	-140.6	2	Alpha-glucosidase with specificity for isomaltose, maltose, and palatinose; member of the IMA isomaltase family; not required for isomaltose utilization, but Ima5p overexpression allows the ima1 null mutant to grow on isomaltose [Source:SGD;Acc:S000003752]
J	YJL217W	REE1	1131	-261.1	4	Cytoplasmic protein involved in the regulation of enolase (ENO1); mRNA expression is induced by calcium shortage, copper deficiency (via Mac1p) and the presence of galactose (via Gal4p); mRNA expression is also regulated by the cell cycle [Source:SGD;Acc:S000003753]
J	YJL218W	YJL218W	93	-46	4	Putative protein of unknown function, similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene [Source:SGD;Acc:S000003754]
J	YJL219W	HXT9	259	-39.7	4	Putative hexose transporter that is nearly identical to Hxt11p, has similarity to major facilitator superfamily (MFS) transporters, expression of HXT9 is regulated by transcription factors Pdr1p and Pdr3p [Source:SGD;Acc:S000003755]
J	YJL220W	YJL220W	3	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YJL221C/FSP2 [Source:SGD;Acc:S000003756]
J	YJL221C	IMA4	220	-333.3	4	Alpha-glucosidase with broad substrate specificity for alpha-1,4- and alpha-1,6-glucosides; member of IMA isomaltase family; not required for isomaltose utilization, but Ima4p overexpression allows the ima1 null mutant to grow on isomaltose [Source:SGD;Acc:S000003757]
J	YJL222W	VTH2	563	-353	4	Putative membrane glycoprotein with strong similarity to Vth1p and Pep1p/Vps10p, may be involved in vacuolar protein sorting [Source:SGD;Acc:S000003758]
J	YJL222W-A	YJL222W-A	24	-14.8	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028663]
J	YJL222W-B	YJL222W-B	1	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028664]
J	YJL223C	PAU1	2	-1.1	1	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme; identical to Pau14p [Source:SGD;Acc:S000003759]
J	YJL225C	YJL225C	410	-357	4	Putative protein of unknown function; similarity to DNA helicases that are also encoded within subtelomeric Y' elements and induced in telomerase deficient survivors [Source:SGD;Acc:S000003760]
J	YJL225W-A	YJL225W-A	1	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized gene YJL225C [Source:SGD;Acc:S000028665]
J	YJR001W	AVT1	684	-135.9	4	Vacuolar transporter, imports large neutral amino acids into the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters [Source:SGD;Acc:S000003761]
J	YJR002W	MPP10	1563	-515.8	4	Component of the SSU processome and 90S preribosome, required for pre-18S rRNA processing, interacts with and controls the stability of Imp3p and Imp4p, essential for viability; similar to human Mpp10p [Source:SGD;Acc:S000003762]
J	YJR003C	YJR003C	306	-216.5	4	Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000003763]
J	YJR004C	SAG1	92	-209.4	4	Alpha-agglutinin of alpha-cells, binds to Aga1p during agglutination, N-terminal half is homologous to the immunoglobulin superfamily and contains binding site for a-agglutinin, C-terminal half is highly glycosylated and contains GPI anchor [Source:SGD;Acc:S000003764]
J	YJR005C-A	LSO1	4	-7	2	Putative protein of unknown function, originally identified as a syntenic homolog of an <i>Ashbya gossypii</i> gene [Source:SGD;Acc:S000028523]
J	YJR005W	APL1	402	-242.5	4	Beta-adaptin, large subunit of the clathrin associated protein complex (AP-2); involved in vesicle mediated transport; similar to mammalian beta-chain of the clathrin associated protein complex [Source:SGD;Acc:S000003765]
J	YJR006W	POL31	397	-198.5	4	Subunit of DNA polymerase delta (polymerase III); essential for cell viability; involved in DNA replication and DNA repair [Source:SGD;Acc:S000003766]
J	YJR007W	SUI2	2631	-460.2	4	Alpha subunit of the translation initiation factor eIF2, involved in the identification of the start codon; phosphorylation of Ser51 is required for regulation of translation by inhibiting the exchange of GDP for GTP [Source:SGD;Acc:S000003767]
J	YJR008W	MHO1	398	-331.2	4	Putative protein of unknown function; expression repressed by inosine and choline in an Opi1p-dependent manner; expression induced by mild heat-stress on a non-fermentable carbon source. [Source:SGD;Acc:S000003768]
J	YJR009C	TDH2	7613	-3039.9	4	Glyceraldehyde-3-phosphate dehydrogenase, isozyme 2, involved in glycolysis and gluconeogenesis; tetramer that catalyzes the reaction of glyceraldehyde-3-phosphate to 1,3 bis-phosphoglycerate; detected in the cytoplasm and cell wall [Source:SGD;Acc:S000003769]
J	YJR010C-A	SPC1	325	-44.7	4	Subunit of the signal peptidase complex (SPC), which cleaves the signal sequence from proteins targeted to the endoplasmic reticulum (ER), homolog of the SPC12 subunit of mammalian signal peptidase complex [Source:SGD;Acc:S000003770]
J	YJR010W	MET3	872	-400.5	4	ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism [Source:SGD;Acc:S000003771]
J	YJR011C	YJR011C	115	-119.2	4	Putative protein of unknown function; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000003772]
J	YJR012C	YJR012C	134	-136.7	4	Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W [Source:SGD;Acc:S000003773]
J	YJR013W	GPI14	62	-51	4	Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M [Source:SGD;Acc:S000003774]
J	YJR014W	TMA22	1716	-181.6	4	Protein of unknown function; associates with ribosomes and has a putative RNA binding domain; interacts with Tma20p; similar to human GRAP and human DRP1, which interacts with human Tma20p homolog MCT-1 [Source:SGD;Acc:S000003775]
J	YJR015W	YJR015W	76	-35.7	4	Putative protein of unknown function; localizes to the endoplasmic reticulum and cytoplasm; predicted to encode a membrane transporter based on phylogenetic analysis; YJR015W is a non-essential gene [Source:SGD;Acc:S000003776]
J	YJR016C	ILV3	3418	-5999	4	Dihydroxyacid dehydratase, catalyzes third step in the common pathway leading to biosynthesis of branched-chain amino acids [Source:SGD;Acc:S000003777]
J	YJR017C	ESS1	924	-169.9	4	Peptidylprolyl-cis/trans-isomerase (PPIase) specific for phosphorylated serine and threonine residues N-terminal to proline; regulates phosphorylation of the RNA polymerase II large subunit (Rpo21p) C-terminal domain [Source:SGD;Acc:S000003778]
J	YJR018W	YJR018W	7	-2.1	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003779]
J	YJR019C	TES1	370	-251.5	4	Peroxisomal acyl-CoA thioesterase likely to be involved in fatty acid oxidation rather than fatty acid synthesis; conserved protein also found in human peroxisomes; TES1 mRNA levels increase during growth on fatty acids [Source:SGD;Acc:S000003780]
J	YJR020W	YJR020W	3	-2.2	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003781]
J	YJR021C	REC107	20	-36.6	4	Protein involved in early stages of meiotic recombination; involved in coordination between the initiation of recombination and the first division of meiosis; part of a complex (Rec107p-Mei4p-Rec114p) required for ds break formation [Source:SGD;Acc:S000003782]
J	YJR022W	LSM8	270	-53.6	4	Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) that is part of spliceosomal U6 snRNP and is also implicated in processing of pre-tRNA, pre-snoRNA, and pre-rRNA [Source:SGD;Acc:S000003783]
J	YJR023C	YJR023C	1	-1.4	1	Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing [Source:SGD;Acc:S000003784]
J	YJR024C	MDE1	504	-170.1	4	5'-methylthioribulose-1-phosphate dehydratase; acts in the methionine salvage pathway; potential Smt3p sumoylation substrate; expression downregulated by caspofungin and deletion mutant is caspofungin resistant [Source:SGD;Acc:S000003785]
J	YJR025C	BNA1	1430	-338.6	4	3-hydroxyanthranilic acid dioxygenase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p [Source:SGD;Acc:S000003786]
J	YJR026W	YJR026W	4675	-1737.6	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000003787]
J	YJR027W	YJR027W	4986	-2501.6	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000003788]
J	YJR028W	YJR028W	4638	-1756.8	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000003789]
J	YJR029W	YJR029W	4989	-2454.6	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000003790]
J	YJR030C	YJR030C	16	-7.5	2	Putative protein of unknown function; expression repressed in carbon limited vs carbon replete chemostat cultures; YJR030C is a non-essential gene [Source:SGD;Acc:S000003791]
J	YJR031C	GEA1	497	-473.8	4	Guanine nucleotide exchange factor for ADP ribosylation factors (ARFs), involved in vesicular transport between the Golgi and ER, Golgi organization, and actin cytoskeleton organization; similar to but not functionally redundant with Gea2p [Source:SGD;Acc:S000003792]
J	YJR032W	CPR7	526	-203.9	4	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity [Source:SGD;Acc:S000003793]
J	YJR033C	RAV1	717	-611.1	4	Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate [Source:SGD;Acc:S000003794]
J	YJR034W	PET191	337	-114.3	4	Protein required for assembly of cytochrome c oxidase; exists as an oligomer that is integral to the mitochondrial inner membrane and faces the intermembrane space; contains a twin Cx9C motif [Source:SGD;Acc:S000003795]
J	YJR035W	RAD26	140	-278.7	4	Protein involved in transcription-coupled nucleotide excision repair of UV-induced DNA lesions; recruitment to DNA lesions is dependent on an elongating RNA polymerase II; homolog of human CSB protein [Source:SGD;Acc:S000003796]
J	YJR036C	HUL4	42	-36.6	2	Protein with similarity to hect domain E3 ubiquitin-protein ligases, not essential for viability [Source:SGD;Acc:S000003797]
J	YJR037W	YJR037W	3	-1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene HUL4/YJR036C; deletion mutant has decreased spore survival in Drosophila feces [Source:SGD;Acc:S000003798]
J	YJR038C	YJR038C	11	-2.7	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003799]
J	YJR039W	YJR039W	44	-150.1	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003800]
J	YJR040W	GEF1	291	-233.7	4	Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels [Source:SGD;Acc:S000003801]
J	YJR041C	URB2	790	-499.4	4	Nucleolar protein required for normal metabolism of the rRNA primary transcript, proposed to be involved in ribosome biogenesis [Source:SGD;Acc:S000003802]
J	YJR042W	NUP85	924	-935.4	4	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); required for assembly of the subcomplex and also for formation of the nucleocytoplasmic Gsp1p concentration gradient that plays a role in nuclear trafficking; the Nup84 subcomplex h  ole in transcription elongation [Source:SGD;Acc:S000003803]
J	YJR043C	POL32	195	-89.8	4	Third subunit of DNA polymerase delta, involved in chromosomal DNA replication; required for error-prone DNA synthesis in the presence of DNA damage and processivity; interacts with Hys2p, PCNA (Pol30p), and Pol1p [Source:SGD;Acc:S000003804]
J	YJR044C	VPS55	3	-11.7	2	Late endosomal protein involved in late endosome to vacuole trafficking; functional homolog of human obesity receptor gene-related protein (OB-RGRP) [Source:SGD;Acc:S000003805]
J	YJR045C	SSC1	5170	-2073.6	4	Hsp70 family ATPase, constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease [Source:SGD;Acc:S000003806]
J	YJR046W	TAH11	302	-266.7	4	DNA replication licensing factor, required for pre-replication complex assembly [Source:SGD;Acc:S000003807]
J	YJR047C	ANB1	2040	-197.5	4	Translation elongation factor eIF-5A, previously thought to function in translation initiation; similar to and functionally redundant with Hyp2p; undergoes an essential hypusination modification; expressed under anaerobic conditions [Source:SGD;Acc:S000003808]
J	YJR048W	CYC1	1272	-370.7	4	Cytochrome c, isoform 1; electron carrier of the mitochondrial intermembrane space that transfers electrons from ubiquinone-cytochrome c oxidoreductase to cytochrome c oxidase during cellular respiration [Source:SGD;Acc:S000003809]
J	YJR049C	UTR1	510	-265.6	4	ATP-NADH kinase; phosphorylates both NAD and NADH; active as a hexamer; enhances the activity of ferric reductase (Fre1p) [Source:SGD;Acc:S000003810]
J	YJR050W	ISY1	123	-123.5	4	Member of NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of spliceosome containing U2, U5, and U6 snRNAs, interacts with Prp16p to modulate splicing fidelity; isy1 syf2 cells have defective spindles [Source:SGD;Acc:S000003811]
J	YJR051W	OSM1	964	-514.6	4	Fumarate reductase, catalyzes the reduction of fumarate to succinate, required for the reoxidation of intracellular NADH under anaerobic conditions; mutations cause osmotic sensitivity [Source:SGD;Acc:S000003812]
J	YJR052W	RAD7	273	-201	4	Protein that recognizes and binds damaged DNA in an ATP-dependent manner (with Rad16p) during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 4 (NEF4) and the Elongin-Cullin-Socs (ECS) ligase complex [Source:SGD;Acc:S000003813]
J	YJR053W	BFA1	127	-136.6	4	Component of the GTPase-activating Bfa1p-Bub2p complex involved in multiple cell cycle checkpoint pathways that control exit from mitosis [Source:SGD;Acc:S000003814]
J	YJR054W	KCH1	64	-53.6	4	Vacuolar protein of unknown function; potential Cdc28p substrate [Source:SGD;Acc:S000003815]
J	YJR055W	HIT1	125	-58.3	4	Protein of unknown function, required for growth at high temperature [Source:SGD;Acc:S000003816]
J	YJR056C	YJR056C	54	-23.2	2	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000003817]
J	YJR057W	CDC8	327	-721.7	4	Thymidylate and uridylate kinase, functions in de novo biosynthesis of pyrimidine deoxyribonucleotides; converts dTMP to dTDP and dUMP to dUTP; essential for mitotic and meiotic DNA replication; homologous to S. pombe Tmp1p [Source:SGD;Acc:S000003818]
J	YJR058C	APS2	83	-45.3	4	Small subunit of the clathrin-associated adaptor complex AP-2, which is involved in protein sorting at the plasma membrane; related to the sigma subunit of the mammalian plasma membrane clathrin-associated protein (AP-2) complex [Source:SGD;Acc:S000003819]
J	YJR059W	PTK2	1828	-1211.4	4	Putative serine/threonine protein kinase involved in regulation of ion transport across plasma membrane; enhances spermine uptake [Source:SGD;Acc:S000003820]
J	YJR060W	CBF1	1533	-357.3	4	Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such   4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation [Source:SGD;Acc:S000003821]
J	YJR061W	YJR061W	38	-163.9	4	Putative protein of unknown function; non-essential gene with similarity to Mnn4, a putative membrane protein involved in glycosylation; transcription repressed by Rm101p [Source:SGD;Acc:S000003822]
J	YJR062C	NTA1	432	-222.7	4	Amidase, removes the amide group from N-terminal asparagine and glutamine residues to generate proteins with N-terminal aspartate and glutamate residues that are targets of ubiquitin-mediated degradation [Source:SGD;Acc:S000003823]
J	YJR063W	RPA12	877	-87.8	4	RNA polymerase I subunit A12.2; contains two zinc binding domains, and the N terminal domain is responsible for anchoring to the RNA pol I complex [Source:SGD;Acc:S000003824]
J	YJR064W	CCT5	2224	-634.6	4	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo [Source:SGD;Acc:S000003825]
J	YJR065C	ARP3	2228	-931.2	4	Essential component of the Arp2/3 complex, which is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity [Source:SGD;Acc:S000003826]
J	YJR066W	TOR1	777	-1435.9	4	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis [Source:SGD;Acc:S000003827]
J	YJR067C	YAE1	218	-67.2	4	Protein of unknown function, essential for growth under standard (aerobic) conditions but not under anaerobic conditions [Source:SGD;Acc:S000003828]
J	YJR068W	RFC2	1174	-350.4	4	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon [Source:SGD;Acc:S000003829]
J	YJR069C	HAM1	1668	-156.8	4	Conserved protein with deoxyribonucleoside triphosphate pyrophosphohydrolase activity, mediates exclusion of noncanonical purines from deoxyribonucleoside triphosphate pools; mutant is sensitive to the base analog 6-N-hydroxylaminopurine [Source:SGD;Acc:S000003830]
J	YJR070C	LIA1	2399	-567.1	4	Deoxyhypusine hydroxylase, a HEAT-repeat containing metalloenzyme that catalyzes hypusine formation; binds to and is required for the modification of Hyp2p (eIF5A); complements S. pombe mmd1 mutants defective in mitochondrial positioning [Source:SGD;Acc:S000003831]
J	YJR071W	YJR071W	17	-4.9	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003832]
J	YJR072C	NPA3	1693	-271.4	4	Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kina  plex; human homolog XAB1 interacts with human RNA polymerase II [Source:SGD;Acc:S000003833]
J	YJR073C	OPI3	520	-231.2	4	Phospholipid methyltransferase (methylene-fatty-acyl-phospholipid synthase), catalyzes the last two steps in phosphatidylcholine biosynthesis [Source:SGD;Acc:S000003834]
J	YJR074W	MOG1	553	-155.2	4	Conserved nuclear protein that interacts with GTP-Gsp1p, which is a Ran homolog of the Ras GTPase family, and stimulates nucleotide release, involved in nuclear protein import, nucleotide release is inhibited by Yrb1p [Source:SGD;Acc:S000003835]
J	YJR075W	HOC1	716	-243.7	4	Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele [Source:SGD;Acc:S000003836]
J	YJR076C	CDC11	1592	-1083.3	4	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds f  ruiting cell division factors and as barriers to prevent diffusion of specific proteins between mother and daughter cells [Source:SGD;Acc:S000003837]
J	YJR077C	MIR1	2861	-1151.7	4	Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated [Source:SGD;Acc:S000003838]
J	YJR078W	BNA2	207	-268.4	4	Putative tryptophan 2,3-dioxygenase or indoleamine 2,3-dioxygenase, required for de novo biosynthesis of NAD from tryptophan via kynurenine; interacts genetically with telomere capping gene CDC13; regulated by Hst1p and Aftp [Source:SGD;Acc:S000003839]
J	YJR079W	YJR079W	0	nf	1	Putative protein of unknown function; mutation results in impaired mitochondrial respiration [Source:SGD;Acc:S000003840]
J	YJR080C	AIM24	774	-527	4	Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000003841]
J	YJR082C	EAF6	93	-37.3	4	Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3 [Source:SGD;Acc:S000003842]
J	YJR083C	ACF4	572	-175.6	4	Protein of unknown function, computational analysis of large-scale protein-protein interaction data suggests a possible role in actin cytoskeleton organization; potential Cdc28p substrate [Source:SGD;Acc:S000003843]
J	YJR084W	YJR084W	203	-181.9	4	Protein that forms a complex with Thp3p; may have a role in transcription elongation and/or mRNA splicing; identified as a COP9 signalosome component but phenotype and interactions suggest it may not be involved with the signalosome [Source:SGD;Acc:S000003844]
J	YJR085C	YJR085C	399	-234.3	4	Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003845]
J	YJR086W	STE18	417	-60.7	4	G protein gamma subunit, forms a dimer with Ste4p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste4p to dampen signaling; C-terminus is palmitoylated and farnesylated, which are required for normal signaling [Source:SGD;Acc:S000003846]
J	YJR087W	YJR087W	20	-5.1	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2 [Source:SGD;Acc:S000003847]
J	YJR088C	EMC2	899	-151.2	4	Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response [Source:SGD;Acc:S000003848]
J	YJR089W	BIR1	396	-372.9	4	Subunit of chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), which regulates chromosome segregation; required for chromosome bi-orientation and for spindle assembly checkpoint activation upon reduced sister kinetochore tension [Source:SGD;Acc:S000003849]
J	YJR090C	GRR1	361	-1811.8	4	F-box protein component of the SCF ubiquitin-ligase complex; involved in carbon catabolite repression, glucose-dependent divalent cation transport, high-affinity glucose transport, morphogenesis, and sulfite detoxification [Source:SGD;Acc:S000003850]
J	YJR091C	JSN1	805	-324.1	4	Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl [Source:SGD;Acc:S000003851]
J	YJR092W	BUD4	755	-1105.5	4	Involved in bud-site selection and required for the axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding; required for the formation of a double septin ring, and generall  the organization of septin structures; potential Cdc28p substrate [Source:SGD;Acc:S000003852]
J	YJR093C	FIP1	662	-125.4	4	Subunit of cleavage polyadenylation factor (CPF), interacts directly with poly(A) polymerase (Pap1p) to regulate its activity; bridging factor that links Pap1p and the CPF complex via Yth1p [Source:SGD;Acc:S000003853]
J	YJR094C	IME1	3	-3	2	Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p [Source:SGD;Acc:S000003854]
J	YJR094W-A	RPL43B	3055	-346.7	4	Protein component of the large (60S) ribosomal subunit, identical to Rpl43Ap and has similarity to rat L37a ribosomal protein [Source:SGD;Acc:S000003855]
J	YJR095W	SFC1	428	-535.2	4	Mitochondrial succinate-fumarate transporter, transports succinate into and fumarate out of the mitochondrion; required for ethanol and acetate utilization [Source:SGD;Acc:S000003856]
J	YJR096W	YJR096W	750	-324.8	4	Putative xylose and arabinose reductase; member of the aldo-keto reductase (AKR) family; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000003857]
J	YJR097W	JJJ3	93	-55.3	4	Protein of unknown function, contains a J-domain, which is a region with homology to the E. coli DnaJ protein [Source:SGD;Acc:S000003858]
J	YJR098C	YJR098C	163	-148.6	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000003859]
J	YJR099W	YUH1	474	-111.2	4	Ubiquitin C-terminal hydrolase that cleaves ubiquitin-protein fusions to generate monomeric ubiquitin; hydrolyzes the peptide bond at the C-terminus of ubiquitin; also the major processing enzyme for the ubiquitin-like protein Rub1p [Source:SGD;Acc:S000003860]
J	YJR100C	AIM25	161	-139.7	4	Putative protein of unknown function; non-tagged protein is detected in purified mitochondria in high-throughput studies; similar to murine NOR1; null mutant is viable and displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000003861]
J	YJR101W	RSM26	549	-196.4	4	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000003862]
J	YJR102C	VPS25	139	-94	4	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome [Source:SGD;Acc:S000003863]
J	YJR103W	URA8	1464	-581	4	Minor CTP synthase isozyme (see also URA7), catalyzes the ATP-dependent transfer of the amide nitrogen from glutamine to UTP, forming CTP, the final step in de novo biosynthesis of pyrimidines; involved in phospholipid biosynthesis [Source:SGD;Acc:S000003864]
J	YJR104C	SOD1	3315	-1308.6	4	Cytosolic copper-zinc superoxide dismutase; some mutations are analogous to those that cause ALS (amyotrophic lateral sclerosis) in humans [Source:SGD;Acc:S000003865]
J	YJR105W	ADO1	3168	-653	4	Adenosine kinase, required for the utilization of S-adenosylmethionine (AdoMet); may be involved in recycling adenosine produced through the methyl cycle [Source:SGD;Acc:S000003866]
J	YJR106W	ECM27	17	-62.8	4	Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p [Source:SGD;Acc:S000003867]
J	YJR107W	YJR107W	18	-28.8	2	Putative protein of unknown function; has sequence or structural similarity to lipases [Source:SGD;Acc:S000003868]
J	YJR108W	ABM1	4	-2.4	2	Protein of unknown function, required for normal microtubule organization [Source:SGD;Acc:S000003869]
J	YJR109C	CPA2	3401	-1848.4	4	Large subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor [Source:SGD;Acc:S000003870]
J	YJR110W	YMR1	126	-1743.2	4	Phosphatidylinositol 3-phosphate (PI3P) phosphatase; involved in various protein sorting pathways, including CVT targeting and endosome to vacuole transport; has similarity to the conserved myotubularin dual specificity phosphatase family [Source:SGD;Acc:S000003871]
J	YJR111C	YJR111C	375	-145.3	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria [Source:SGD;Acc:S000003872]
J	YJR112W	NNF1	179	-96.6	4	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation [Source:SGD;Acc:S000003873]
J	YJR112W-A	YJR112W-A	3	-18.8	2	Putative protein of unknown function; identified based on homology to <i>Ashbya gossypii</i> [Source:SGD;Acc:S000028513]
J	YJR113C	RSM7	544	-152.3	4	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S7 ribosomal protein [Source:SGD;Acc:S000003874]
J	YJR114W	YJR114W	4	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSM7/YJR113C [Source:SGD;Acc:S000003875]
J	YJR115W	YJR115W	2	-2.3	2	Putative protein of unknown function [Source:SGD;Acc:S000003876]
J	YJR116W	TDA4	19	-29.5	3	Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele [Source:SGD;Acc:S000003877]
J	YJR117W	STE24	1346	-313	4	Highly conserved zinc metalloprotease that functions in two steps of a-factor maturation, C-terminal CAAX proteolysis and the first step of N-terminal proteolytic processing; contains multiple transmembrane spans [Source:SGD;Acc:S000003878]
J	YJR118C	ILM1	291	-214.1	4	Protein of unknown function; may be involved in mitochondrial DNA maintenance; required for slowed DNA synthesis-induced filamentous growth [Source:SGD;Acc:S000003879]
J	YJR119C	JHD2	67	-248	4	JmjC domain family histone demethylase specific for H3-K4 (histone H3 Lys4); removes methyl groups specifically added by Set1p methyltransferase; protein levels regulated by Not4p (E3 ubiquitin ligase) polyubiquitin-mediated degradation [Source:SGD;Acc:S000003880]
J	YJR120W	YJR120W	2	-11.7	2	Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p [Source:SGD;Acc:S000003881]
J	YJR121W	ATP2	4356	-1792.5	4	Beta subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated [Source:SGD;Acc:S000003882]
J	YJR122W	IBA57	237	-161.4	4	Mitochondrial matrix protein involved in the incorporation of iron-sulfur clusters into mitochondrial aconitase-type proteins; activates the radical-SAM family members Bio2p and Lip5p; interacts with Ccr4p in the two-hybrid system [Source:SGD;Acc:S000003883]
J	YJR123W	RPS5	5212	-657.8	4	Protein component of the small (40S) ribosomal subunit, the least basic of the non-acidic ribosomal proteins; phosphorylated in vivo; essential for viability; has similarity to E. coli S7 and rat S5 ribosomal proteins [Source:SGD;Acc:S000003884]
J	YJR124C	YJR124C	92	-34.8	4	Putative protein of unknown function; expression induced under calcium shortage [Source:SGD;Acc:S000003885]
J	YJR125C	ENT3	1669	-452.5	4	Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p [Source:SGD;Acc:S000003886]
J	YJR126C	VPS70	510	-362	4	Protein of unknown function involved in vacuolar protein sorting [Source:SGD;Acc:S000003887]
J	YJR127C	RSF2	265	-376.8	4	Zinc-finger protein involved in transcriptional control of both nuclear and mitochondrial genes, many of which specify products required for glycerol-based growth, respiration, and other functions [Source:SGD;Acc:S000003888]
J	YJR128W	YJR128W	5	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSF2 [Source:SGD;Acc:S000003889]
J	YJR129C	EFM3	124	-114.8	4	Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003890]
J	YJR130C	STR2	312	-242.4	4	Cystathionine gamma-synthase, converts cysteine into cystathionine [Source:SGD;Acc:S000003891]
J	YJR131W	MNS1	433	-379.9	4	Alpha-1,2-mannosidase involved in ER quality control; catalyzes the removal of one mannose residue from Man9GlcNAc to produce a single isomer of Man8GlcNAc in N-linked oligosaccharide biosynthesis; integral to ER membrane [Source:SGD;Acc:S000003892]
J	YJR132W	NMD5	741	-439	4	Karyopherin, a carrier protein involved in nuclear import of proteins; importin beta homolog [Source:SGD;Acc:S000003893]
J	YJR133W	XPT1	818	-184.6	4	Xanthine-guanine phosphoribosyl transferase, required for xanthine utilization and for optimal utilization of guanine [Source:SGD;Acc:S000003894]
J	YJR134C	SGM1	570	-477.8	4	Protein of unknown function, required for wild-type growth rate on galactose and mannose; localizes to COPI coated vesicles and the Golgi apparatus [Source:SGD;Acc:S000003895]
J	YJR135C	MCM22	55	-141.5	4	Protein involved in minichromosome maintenance; component of the kinetochore; binds to centromeric DNA in a Ctf19p-dependent manner [Source:SGD;Acc:S000003896]
J	YJR135W-A	TIM8	930	-194.1	4	Mitochondrial intermembrane space protein, forms a complex with Tim13p that delivers a subset of hydrophobic proteins to the TIM22 complex for inner membrane insertion; homolog of human TIMM8A, implicated in Mohr-Tranebjaerg syndrome [Source:SGD;Acc:S000007348]
J	YJR136C	TTI2	91	-118.9	4	Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti2p; may interact with Rsm23p; GFP-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003897]
J	YJR137C	MET5	1397	-1247.5	4	Sulfite reductase beta subunit, involved in amino acid biosynthesis, transcription repressed by methionine [Source:SGD;Acc:S000003898]
J	YJR138W	IML1	647	-484.4	4	Subunit of both the SEA (Seh1-associated) and Iml1p complexes; SEA complex is a coatomer-related complex that associates dynamically with the vacuole; Iml1p complex (Iml1p-Npr2p-Npr3p) is required for non-nitrogen-starvation (NNS)-induced autophagy;  ized to either pre-autophagosomal structures (PAS) or non-PAS structures during NNS-induced autophagy; has an N-terminal CDC48-like domain (RANS) required for NNS-induced autophagy and a C-terminal DEP domain [Source:SGD;Acc:S000003899]
J	YJR139C	HOM6	3069	-995.6	4	Homoserine dehydrogenase (L-homoserine:NADP oxidoreductase), dimeric enzyme that catalyzes the third step in the common pathway for methionine and threonine biosynthesis; enzyme has nucleotide-binding, dimerization and catalytic regions [Source:SGD;Acc:S000003900]
J	YJR140C	HIR3	230	-378.4	4	Subunit of the HIR complex; a nucleosome assembly complex involved in regulation of histone gene transcription; involved in position-dependent gene silencing and nucleosome reassembly; ortholog of human CABIN1 protein [Source:SGD;Acc:S000003901]
J	YJR140W-A	YJR140W-A	0	nf	1	Dubious open reading frame; completely overlaps the verified gene HIR3; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028666]
J	YJR141W	YJR141W	12	-51	2	Essential protein of unknown function [Source:SGD;Acc:S000003902]
J	YJR142W	YJR142W	449	-179.4	4	Putative protein of unknown function; GST fusion protein is a Dbf2-Mob1 phosphoylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition [Source:SGD;Acc:S000003903]
J	YJR143C	PMT4	1155	-399.7	4	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; appears to form homodimers in vivo and does not complex with other Pmt proteins; target for new antifungals [Source:SGD;Acc:S000003904]
J	YJR144W	MGM101	1513	-468.1	4	Protein with a role in mitochondrial DNA recombinational repair; binds to and catalyzes the annealing of single-stranded mtDNA; oligomerizes to form rings and filaments; related to Rad52-type recombination proteins, with limited overall similarity b  ring conserved functionally important residues; component of the mitochondrial nucleoid, required for the repair of oxidative mtDNA damage [Source:SGD;Acc:S000003905]
J	YJR145C	RPS4A	4641	-1051.6	4	Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; identical to Rps4Bp and has similarity to rat S4 ribosomal protein [Source:SGD;Acc:S000003906]
J	YJR146W	YJR146W	2	-2.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene HMS2 [Source:SGD;Acc:S000003907]
J	YJR147W	HMS2	62	-42.6	4	Protein with similarity to heat shock transcription factors; overexpression suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant [Source:SGD;Acc:S000003908]
J	YJR148W	BAT2	2475	-669.1	4	Cytosolic branched-chain amino acid (BCAA) aminotransferase, preferentially involved in BCAA catabolism; homolog of murine ECA39; highly expressed during stationary phase and repressed during logarithmic phase [Source:SGD;Acc:S000003909]
J	YJR149W	YJR149W	100	-163.6	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003910]
J	YJR150C	DAN1	8	-4.7	2	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth [Source:SGD;Acc:S000003911]
J	YJR151C	DAN4	11	-11	2	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; expressed under anaerobic conditions, completely repressed during aerobic growth [Source:SGD;Acc:S000003912]
J	YJR151W-A	YJR151W-A	1	-1.5	1	Putative protein of unknown function; identified by fungal homology and RT-PCR; predicted to have a role in transcription based on computational guilt by association analysis [Source:SGD;Acc:S000028557]
J	YJR152W	DAL5	59	-82.1	4	Allantoate permease; ureidosuccinate permease; also transports dipeptides, though with lower affinity than for allantoate and ureidosuccinate; expression is constitutive but sensitive to nitrogen catabolite repression [Source:SGD;Acc:S000003913]
J	YJR153W	PGU1	13	-93.1	3	Endo-polygalacturonase, pectolytic enzyme that hydrolyzes the alpha-1,4-glycosidic bonds in the rhamnogalacturonan chains in pectins [Source:SGD;Acc:S000003914]
J	YJR154W	YJR154W	75	-207.2	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000003915]
J	YJR155W	AAD10	7	-3.2	2	Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role [Source:SGD;Acc:S000003916]
J	YJR156C	THI11	130	-139.4	4	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 [Source:SGD;Acc:S000003917]
J	YJR157W	YJR157W	4	-4.4	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003918]
J	YJR158W	HXT16	234	-22.2	2	Protein of unknown function with similarity to hexose transporter family members, expression is repressed by high levels of glucose [Source:SGD;Acc:S000003919]
J	YJR159W	SOR1	42	-113	4	Sorbitol dehydrogenase; expression is induced in the presence of sorbitol or xylose [Source:SGD;Acc:S000003920]
J	YJR160C	MPH3	18	-8.2	2	Alpha-glucoside permease, transports maltose, maltotriose, alpha-methylglucoside, and turanose; identical to Mph2p; encoded in a subtelomeric position in a region likely to have undergone duplication [Source:SGD;Acc:S000003921]
J	YJR161C	COS5	202	-58.5	4	Protein of unknown function, member the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000003922]
J	YJR162C	YJR162C	1	-1.7	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003923]
K	YKL001C	MET14	807	-179.3	4	Adenylylsulfate kinase, required for sulfate assimilation and involved in methionine metabolism [Source:SGD;Acc:S000001484]
K	YKL002W	DID4	482	-105	4	Class E Vps protein of the ESCRT-III complex, required for sorting of integral membrane proteins into lumenal vesicles of multivesicular bodies, and for delivery of newly synthesized vacuolar enzymes to the vacuole, involved in endocytosis [Source:SGD;Acc:S000001485]
K	YKL003C	MRP17	275	-74	4	Mitochondrial ribosomal protein of the small subunit; MRP17 exhibits genetic interactions with PET122, encoding a COX3-specific translational activator [Source:SGD;Acc:S000001486]
K	YKL004W	AUR1	173	-51.7	4	Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance [Source:SGD;Acc:S000001487]
K	YKL005C	BYE1	299	-209.8	4	Negative regulator of transcription elongation, contains a TFIIS-like domain and a PHD finger, multicopy suppressor of temperature-sensitive ess1 mutations, probably binds RNA polymerase II large subunit [Source:SGD;Acc:S000001488]
K	YKL006C-A	SFT1	242	-82.2	4	Intra-Golgi v-SNARE, required for transport of proteins between an early and a later Golgi compartment [Source:SGD;Acc:S000002101]
K	YKL006W	RPL14A	3757	-361.9	4	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl14Bp and has similarity to rat L14 ribosomal protein; rpl14a csh5 double null mutant exhibits synthetic slow growth [Source:SGD;Acc:S000001489]
K	YKL007W	CAP1	1287	-232.8	4	Alpha subunit of the capping protein (CP) heterodimer (Cap1p and Cap2p) which binds to the barbed ends of actin filaments preventing further polymerization; localized predominantly to cortical actin patches [Source:SGD;Acc:S000001490]
K	YKL008C	LAC1	715	-103.8	4	Ceramide synthase component, involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lag1p [Source:SGD;Acc:S000001491]
K	YKL009W	MRT4	1918	-340.3	4	Protein involved in mRNA turnover and ribosome assembly, localizes to the nucleolus [Source:SGD;Acc:S000001492]
K	YKL010C	UFD4	907	-681.4	4	Ubiquitin-protein ligase (E3) that interacts with Rpt4p and Rpt6p, two subunits of the 19S particle of the 26S proteasome; cytoplasmic E3 involved in the degradation of ubiquitin fusion proteins [Source:SGD;Acc:S000001493]
K	YKL011C	CCE1	126	-146.5	4	Mitochondrial cruciform cutting endonuclease, cleaves Holliday junctions formed during recombination of mitochondrial DNA [Source:SGD;Acc:S000001494]
K	YKL012W	PRP40	248	-548	4	U1 snRNP protein involved in splicing, interacts with the branchpoint-binding protein during the formation of the second commitment complex [Source:SGD;Acc:S000001495]
K	YKL013C	ARC19	1259	-179.1	4	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches [Source:SGD;Acc:S000001496]
K	YKL014C	URB1	1249	-919.8	4	Nucleolar protein required for the normal accumulation of 25S and 5.8S rRNAs, associated with the 27SA2 pre-ribosomal particle; proposed to be involved in the biogenesis of the 60S ribosomal subunit [Source:SGD;Acc:S000001497]
K	YKL015W	PUT3	98	-54.3	4	Transcriptional activator of proline utilization genes, constitutively binds PUT1 and PUT2 promoter sequences as a dimer and undergoes a conformational change to form the active state; differentially phosphorylated in the presence of different nitog  rces; has a Zn(2)-Cys(6) binuclear cluster domain [Source:SGD;Acc:S000001498]
K	YKL016C	ATP7	1583	-317.8	4	Subunit d of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis [Source:SGD;Acc:S000001499]
K	YKL017C	HCS1	254	-194.5	4	Hexameric DNA polymerase alpha-associated DNA helicase A involved in lagging strand DNA synthesis; contains single-stranded DNA stimulated ATPase and dATPase activities; replication protein A stimulates helicase and ATPase activities [Source:SGD;Acc:S000001500]
K	YKL018C-A	YKL018C-A	46	-32.3	4	Putative protein of unknown function; identified by homology; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000007615]
K	YKL018W	SWD2	530	-188.1	4	Subunit of the COMPASS (Set1C) complex, which methylates histone H3 on lys 4 and is involved in telomeric silencing; subunit of CPF (cleavage and polyadenylation factor), a complex involved in RNAP II transcription termination [Source:SGD;Acc:S000001501]
K	YKL019W	RAM2	347	-156.6	4	Alpha subunit of both the farnesyltransferase and type I geranylgeranyltransferase that catalyze prenylation of proteins containing a CAAX consensus motif; essential protein required for membrane localization of Ras proteins and a-factor [Source:SGD;Acc:S000001502]
K	YKL020C	SPT23	292	-219.1	4	ER membrane protein involved in regulation of OLE1 transcription, acts with homolog Mga2p; inactive ER form dimerizes and one subunit is then activated by ubiquitin/proteasome-dependent processing followed by nuclear targeting [Source:SGD;Acc:S000001503]
K	YKL021C	MAK11	1232	-269	4	Protein involved in an early, nucleolar step of 60S ribosomal subunit biogenesis; essential for cell growth and replication of killer M1 dsRNA virus; contains four beta-transducin repeats [Source:SGD;Acc:S000001504]
K	YKL022C	CDC16	353	-596.5	4	Subunit of the anaphase-promoting complex/cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; required for sporulation [Source:SGD;Acc:S000001505]
K	YKL023C-A	YKL023C-A	27	-16.8	4	Putative protein of unknown function [Source:SGD;Acc:S000113559]
K	YKL023W	YKL023W	339	-182.5	4	Putative protein of unknown function, predicted by computational methods to be involved in mRNA degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001506]
K	YKL024C	URA6	1424	-223.7	4	Uridylate kinase, catalyzes the seventh enzymatic step in the de novo biosynthesis of pyrimidines, converting uridine monophosphate (UMP) into uridine-5'-diphosphate (UDP) [Source:SGD;Acc:S000001507]
K	YKL025C	PAN3	491	-216.8	4	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes [Source:SGD;Acc:S000001508]
K	YKL026C	GPX1	97	-138.5	4	Phospholipid hydroperoxide glutathione peroxidase induced by glucose starvation that protects cells from phospholipid hydroperoxides and nonphospholipid peroxides during oxidative stress [Source:SGD;Acc:S000001509]
K	YKL027W	TCD2	765	-410.8	4	Protein of unknown function, localized to the mitochondrial outer membrane [Source:SGD;Acc:S000001510]
K	YKL028W	TFA1	571	-427.9	4	TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening [Source:SGD;Acc:S000001511]
K	YKL029C	MAE1	2193	-1223.8	4	Mitochondrial malic enzyme, catalyzes the oxidative decarboxylation of malate to pyruvate, which is a key intermediate in sugar metabolism and a precursor for synthesis of several amino acids [Source:SGD;Acc:S000001512]
K	YKL030W	YKL030W	4	-1.7	1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene MAE1 [Source:SGD;Acc:S000001513]
K	YKL031W	YKL031W	1	-1.8	1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species [Source:SGD;Acc:S000001514]
K	YKL032C	IXR1	405	-182.2	4	Protein that binds DNA containing intrastrand cross-links formed by cisplatin, contains two HMG (high mobility group box) domains, which confer the ability to bend cisplatin-modified DNA; mediates aerobic transcriptional repression of COX5b [Source:SGD;Acc:S000001515]
K	YKL033W	TTI1	243	-165.4	4	Putative protein of unknown function; subunit of the ASTRA complex which is part of the chromatin remodeling machinery; similar to S. pombe Tti1p; detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001516]
K	YKL033W-A	YKL033W-A	1193	-303.9	4	Putative protein of unknown function; similar to uncharacterized proteins from other fungi [Source:SGD;Acc:S000007242]
K	YKL034W	TUL1	90	-97.8	4	Golgi-localized RING-finger ubiquitin ligase (E3), involved in ubiquitinating and sorting membrane proteins that contain polar transmembrane domains to multivesicular bodies for delivery to the vacuole for quality control purposes [Source:SGD;Acc:S000001517]
K	YKL035W	UGP1	3601	-1387.5	4	UDP-glucose pyrophosphorylase (UGPase), catalyses the reversible formation of UDP-Glc from glucose 1-phosphate and UTP, involved in a wide variety of metabolic pathways, expression modulated by Pho85p through Pho4p [Source:SGD;Acc:S000001518]
K	YKL036C	YKL036C	5	-9.1	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W [Source:SGD;Acc:S000001519]
K	YKL037W	AIM26	3	-1.7	1	Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss; null mutation confers sensitivity to tunicamycin and DTT [Source:SGD;Acc:S000001520]
K	YKL038W	RGT1	388	-198.2	4	Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose; binds to promoters and acts both as a transcriptional activator and repressor [Source:SGD;Acc:S000001521]
K	YKL039W	PTM1	560	-138.2	4	Protein of unknown function, copurifies with late Golgi vesicles containing the v-SNARE Tlg2p [Source:SGD;Acc:S000001522]
K	YKL040C	NFU1	1197	-257	4	Protein involved in iron metabolism in mitochondria; similar to NifU, which is a protein required for the maturation of the Fe/S clusters of nitrogenase in nitrogen-fixing bacteria [Source:SGD;Acc:S000001523]
K	YKL041W	VPS24	314	-137	4	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); forms an ESCRT-III subcomplex with Did4p; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway [Source:SGD;Acc:S000001524]
K	YKL042W	SPC42	529	-256.3	4	Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane [Source:SGD;Acc:S000001525]
K	YKL043W	PHD1	70	-21	4	Transcriptional activator that enhances pseudohyphal growth; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; regulates expression of FLO11, an adhesin required for pseudohyphal filament formation; similar to StuA,   nidulans developmental regulator; potential Cdc28p substrate [Source:SGD;Acc:S000001526]
K	YKL044W	YKL044W	2	-3.6	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001527]
K	YKL045W	PRI2	275	-250.6	4	Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair [Source:SGD;Acc:S000001528]
K	YKL046C	DCW1	350	-76.8	4	Putative mannosidase, GPI-anchored membrane protein required for cell wall biosynthesis in bud formation;homologous to Dfg5p [Source:SGD;Acc:S000001529]
K	YKL047W	ANR2	403	-361.1	4	Putative protein of unknown function, predicted to be palmitoylated; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001530]
K	YKL048C	ELM1	152	-173.6	4	Serine/threonine protein kinase that regulates cellular morphogenesis, septin behavior, and cytokinesis; required for the regulation of other kinases; forms part of the bud neck ring [Source:SGD;Acc:S000001531]
K	YKL049C	CSE4	34	-33.5	4	Centromere protein that resembles histone H3, required for proper kinetochore function; homolog of human CENP-A; levels are regulated by E3 ubiquitin ligase Psh1p [Source:SGD;Acc:S000001532]
K	YKL050C	YKL050C	108	-412	4	Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p [Source:SGD;Acc:S000001533]
K	YKL051W	SFK1	192	-87.3	4	Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane [Source:SGD;Acc:S000001534]
K	YKL052C	ASK1	487	-249.1	4	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; phosphorylated during the cell cycle by cyclin-dependent kinases [Source:SGD;Acc:S000001535]
K	YKL053C-A	MDM35	299	-185.2	4	Mitochondrial intermembrane space protein; mutation affects mitochondrial distribution and morphology; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000007243]
K	YKL053W	YKL053W	8	-12.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF ASK1 [Source:SGD;Acc:S000001536]
K	YKL054C	DEF1	2491	-966	4	RNAPII degradation factor, forms a complex with Rad26p in chromatin, enables ubiquitination and proteolysis of RNAPII present in an elongation complex; mutant is deficient in Zip1p loading onto chromosomes during meiosis [Source:SGD;Acc:S000001537]
K	YKL055C	OAR1	87	-77.4	4	Mitochondrial 3-oxoacyl-[acyl-carrier-protein] reductase, may comprise a type II mitochondrial fatty acid synthase along with Mct1p [Source:SGD;Acc:S000001538]
K	YKL056C	TMA19	3259	-1018.5	4	Protein that associates with ribosomes; homolog of translationally controlled tumor protein; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and relocates to the mitochondrial outer surface upon oxidative stress [Source:SGD;Acc:S000001539]
K	YKL057C	NUP120	900	-1006.6	4	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); required for even distribution of NPCs around the nuclear envelope, involved in establishment of a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; the Nup84 sub  x has a role in transcription elongation [Source:SGD;Acc:S000001540]
K	YKL058W	TOA2	593	-137.6	4	TFIIA small subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to smallest subunit of human and Drosophila TFIIA [Source:SGD;Acc:S000001541]
K	YKL059C	MPE1	358	-158.5	4	Essential conserved subunit of CPF (cleavage and polyadenylation factor), plays a role in 3' end formation of mRNA via the specific cleavage and polyadenylation of pre-mRNA, contains a putative RNA-binding zinc knuckle motif [Source:SGD;Acc:S000001542]
K	YKL060C	FBA1	6434	-3013.1	4	Fructose 1,6-bisphosphate aldolase, required for glycolysis and gluconeogenesis; catalyzes conversion of fructose 1,6 bisphosphate to glyceraldehyde-3-P and dihydroxyacetone-P; locates to mitochondrial outer surface upon oxidative stress [Source:SGD;Acc:S000001543]
K	YKL061W	BLI1	60	-67.1	4	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome [Source:SGD;Acc:S000001544]
K	YKL062W	MSN4	692	-308.9	4	Transcriptional activator related to Msn2p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression [Source:SGD;Acc:S000001545]
K	YKL063C	YKL063C	331	-149.7	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi [Source:SGD;Acc:S000001546]
K	YKL064W	MNR2	621	-335.9	4	Vacuolar membrane protein required for magnesium homeostasis; putative magnesium transporter; has similarity to Alr1p and Alr2p, which mediate influx of Mg2+ and other divalent cations [Source:SGD;Acc:S000001547]
K	YKL065C	YET1	1048	-215.1	4	Endoplasmic reticulum transmembrane protein; may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein [Source:SGD;Acc:S000001548]
K	YKL065W-A	YKL065W-A	113	-78.2	4	Putative protein of unknown function [Source:SGD;Acc:S000113563]
K	YKL066W	YKL066W	3	-2.3	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified gene YNK1 [Source:SGD;Acc:S000001549]
K	YKL067W	YNK1	2040	-289	4	Nucleoside diphosphate kinase, catalyzes the transfer of gamma phosphates from nucleoside triphosphates, usually ATP, to nucleoside diphosphates by a mechanism that involves formation of an autophosphorylated enzyme intermediate [Source:SGD;Acc:S000001550]
K	YKL068W	NUP100	1151	-812.6	4	Subunit of the nuclear pore complex (NPC) that is localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup116p [Source:SGD;Acc:S000001551]
K	YKL068W-A	YKL068W-A	14	-8.3	4	Putative protein of unknown function; identified by homology to <i>Ashbya gossypii</i> [Source:SGD;Acc:S000028524]
K	YKL069W	YKL069W	478	-75.5	4	Methionine-R-sulfoxide reductase, reduces the R enantiomer of free Met-SO, in contrast to Ycl033Cp which reduces Met-R-SO in a peptide linkage; has a role in protection against oxidative stress [Source:SGD;Acc:S000001552]
K	YKL070W	YKL070W	2	-0.1	1	Putative protein of unknown function; expression induced in cells treated with mycotoxins patulin or citrinin; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001553]
K	YKL071W	YKL071W	27	-183	4	Putative protein of unknown function; expression induced in cells treated with the mycotoxin patulin, and also the quinone methide triterpene celastrol; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001554]
K	YKL072W	STB6	58	-105.7	4	Protein that binds Sin3p in a two-hybrid assay [Source:SGD;Acc:S000001555]
K	YKL073W	LHS1	1183	-468.5	4	Molecular chaperone of the endoplasmic reticulum lumen, involved in polypeptide translocation and folding; nucleotide exchange factor for the ER lumenal Hsp70 chaperone Kar2p; regulated by the unfolded protein response pathway [Source:SGD;Acc:S000001556]
K	YKL074C	MUD2	311	-232.9	4	Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65 [Source:SGD;Acc:S000001557]
K	YKL075C	YKL075C	184	-147.4	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; proposed to be involved in resistance to streptozotocin and camptothecin [Source:SGD;Acc:S000001558]
K	YKL076C	PSY1	11	-1.5	1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C [Source:SGD;Acc:S000001559]
K	YKL077W	YKL077W	574	-148.3	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole [Source:SGD;Acc:S000001560]
K	YKL078W	DHR2	488	-282.4	4	Predominantly nucleolar DEAH-box ATP-dependent RNA helicase, required for 18S rRNA synthesis [Source:SGD;Acc:S000001561]
K	YKL079W	SMY1	677	-255.8	4	Protein that interacts with Myo2p, proposed to be involved in exocytosis; N-terminal domain is related to the motor domain of kinesins [Source:SGD;Acc:S000001562]
K	YKL080W	VMA5	2586	-683.3	4	Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane [Source:SGD;Acc:S000001563]
K	YKL081W	TEF4	4124	-982.4	4	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex [Source:SGD;Acc:S000001564]
K	YKL082C	RRP14	745	-210	4	Essential protein, constituent of 66S pre-ribosomal particles; interacts with proteins involved in ribosomal biogenesis and cell polarity; member of the SURF-6 family [Source:SGD;Acc:S000001565]
K	YKL083W	YKL083W	4	-1.4	1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified essential gene RRP14 [Source:SGD;Acc:S000001566]
K	YKL084W	HOT13	79	-49.5	4	Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc [Source:SGD;Acc:S000001567]
K	YKL085W	MDH1	2727	-926.9	4	Mitochondrial malate dehydrogenase, catalyzes interconversion of malate and oxaloacetate; involved in the tricarboxylic acid (TCA) cycle; phosphorylated [Source:SGD;Acc:S000001568]
K	YKL086W	SRX1	166	-64.4	4	Sulfiredoxin, contributes to oxidative stress resistance by reducing cysteine-sulfinic acid groups in the peroxiredoxin Tsa1p, which is formed upon exposure to oxidants; conserved in higher eukaryotes [Source:SGD;Acc:S000001569]
K	YKL087C	CYT2	199	-107.4	4	Cytochrome c1 heme lyase, involved in maturation of cytochrome c1, which is a subunit of the mitochondrial ubiquinol-cytochrome-c reductase; links heme covalently to apocytochrome c1 [Source:SGD;Acc:S000001570]
K	YKL088W	CAB3	862	-308.2	4	Subunit of a phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis; null mutant lethality is complemented by E. coli coaBC [Source:SGD;Acc:S000001571]
K	YKL089W	MIF2	148	-65.6	4	Kinetochore protein with homology to human CENP-C, required for structural integrity of the spindle during anaphase spindle elongation, interacts with histones H2A, H2B, and H4, phosphorylated by Ipl1p [Source:SGD;Acc:S000001572]
K	YKL090W	CUE2	83	-112.5	4	Protein of unknown function; has two CUE domains that bind ubiquitin, which may facilitate intramolecular monoubiquitination [Source:SGD;Acc:S000001573]
K	YKL091C	YKL091C	911	-381.7	4	Putative homolog of Sec14p, which is a phosphatidylinositol/phosphatidylcholine transfer protein involved in lipid metabolism; localizes to the nucleus; contains a CRAL/TRIO domain and binds several lipids in a large-scale study [Source:SGD;Acc:S000001574]
K	YKL092C	BUD2	398	-373.3	4	GTPase activating factor for Rsr1p/Bud1p required for both axial and bipolar budding patterns; mutants exhibit random budding in all cell types [Source:SGD;Acc:S000001575]
K	YKL093W	MBR1	209	-199.8	4	Protein involved in mitochondrial functions and stress response; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants [Source:SGD;Acc:S000001576]
K	YKL094W	YJU3	917	-353.6	4	Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family [Source:SGD;Acc:S000001577]
K	YKL095W	YJU2	215	-151.5	4	Essential protein required for pre-mRNA splicing; associates transiently with the spliceosomal NTC (nineteen complex) and acts after Prp2p to promote the first catalytic reaction of splicing [Source:SGD;Acc:S000001578]
K	YKL096C-B	YKL096C-B	1	-1	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028667]
K	YKL096W	CWP1	1192	-180.2	4	Cell wall mannoprotein that localizes specifically to birth scars of daughter cells, linked to a beta-1,3- and beta-1,6-glucan heteropolymer through a phosphodiester bond; required for propionic acid resistance [Source:SGD;Acc:S000001579]
K	YKL096W-A	CWP2	53	-33.9	4	Covalently linked cell wall mannoprotein, major constituent of the cell wall; plays a role in stabilizing the cell wall; involved in low pH resistance; precursor is GPI-anchored [Source:SGD;Acc:S000001956]
K	YKL097C	YKL097C	4	-1.7	1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species [Source:SGD;Acc:S000001580]
K	YKL098W	MTC2	59	-43.8	4	Protein of unknown function; mtc2 is synthetically sick with cdc13-1 [Source:SGD;Acc:S000001581]
K	YKL099C	UTP11	749	-93.6	4	Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit [Source:SGD;Acc:S000001582]
K	YKL100C	YKL100C	694	-247.5	4	Putative protein of unknown function with similarity to a human minor histocompatibility antigen and signal peptide peptidases; YKL100C is not an essential gene [Source:SGD;Acc:S000001583]
K	YKL100W-A	YKL100W-A	3	-1.5	1	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028840]
K	YKL101W	HSL1	621	-403.2	4	Nim1p-related protein kinase that regulates the morphogenesis and septin checkpoints; associates with the assembled septin filament; required along with Hsl7p for bud neck recruitment, phosphorylation, and degradation of Swe1p [Source:SGD;Acc:S000001584]
K	YKL102C	YKL102C	3	-2.2	2	Dubious open reading frame unlikely to encode a functional protein; deletion confers sensitivity to citric acid; predicted protein would include a thiol-disulfide oxidoreductase active site [Source:SGD;Acc:S000001585]
K	YKL103C	APE1	1868	-787.8	4	Vacuolar aminopeptidase yscI; zinc metalloproteinase that belongs to the peptidase family M18; often used as a marker protein in studies of autophagy and cytosol to vacuole targeting (CVT) pathway [Source:SGD;Acc:S000001586]
K	YKL104C	GFA1	2935	-939.4	4	Glutamine-fructose-6-phosphate amidotransferase, catalyzes the formation of glucosamine-6-P and glutamate from fructose-6-P and glutamine in the first step of chitin biosynthesis [Source:SGD;Acc:S000001587]
K	YKL105C	SEG2	684	-330.3	4	Putative protein of unknown function; similar to A. gossypii SEG gene which is important for stabilizing eisosomes [Source:SGD;Acc:S000001588]
K	YKL106C-A	YKL106C-A	1	-1.1	1	Putative protein of unknown function; identified by homology to uncharacterized proteins in other fungi [Source:SGD;Acc:S000007616]
K	YKL106W	AAT1	424	-247.8	4	Mitochondrial aspartate aminotransferase, catalyzes the conversion of oxaloacetate to aspartate in aspartate and asparagine biosynthesis [Source:SGD;Acc:S000001589]
K	YKL107W	YKL107W	111	-160.5	4	Putative protein of unknown function; proposed to be a palmitoylated membrane protein [Source:SGD;Acc:S000001590]
K	YKL108W	SLD2	92	-93.8	4	Single-stranded DNA origin-binding and annealing protein; required for the initiation of DNA replication; phosphorylated in S phase by cyclin-dependent kinases (Cdks), promoting origin binding, DNA replication and Dpb11p complex formation; component  e preloading complex; unphosphorylated or CDK-phosphorylated Sld2p binds to the MCM2-7 complex;required for the S phase checkpoint [Source:SGD;Acc:S000001591]
K	YKL109W	HAP4	33	-81.4	4	Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex [Source:SGD;Acc:S000001592]
K	YKL110C	KTI12	529	-168.8	4	Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p [Source:SGD;Acc:S000001593]
K	YKL111C	YKL111C	2	-1.4	1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related <i>Saccharomyces</i> species; partially overlaps the verified essential gene ABF1 [Source:SGD;Acc:S000001594]
K	YKL112W	ABF1	1263	-647.6	4	DNA binding protein with possible chromatin-reorganizing activity involved in transcriptional activation, gene silencing, and DNA replication and repair [Source:SGD;Acc:S000001595]
K	YKL113C	RAD27	913	-274.8	4	5' to 3' exonuclease, 5' flap endonuclease, required for Okazaki fragment processing and maturation as well as for long-patch base-excision repair; member of the S. pombe RAD2/FEN1 family [Source:SGD;Acc:S000001596]
K	YKL114C	APN1	878	-302.6	4	Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine [Source:SGD;Acc:S000001597]
K	YKL115C	YKL115C	0	nf	1	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 [Source:SGD;Acc:S000001598]
K	YKL116C	PRR1	424	-744.7	4	Serine/threonine protein kinase that inhibits pheromone induced signalling downstream of MAPK, possibly at the level of the Ste12p transcription factor [Source:SGD;Acc:S000001599]
K	YKL117W	SBA1	1810	-366	4	Co-chaperone that binds to and regulates Hsp90 family chaperones; important for pp60v-src activity in yeast; homologous to the mammalian p23 proteins and like p23 can regulate telomerase activity [Source:SGD;Acc:S000001600]
K	YKL118W	YKL118W	1	-1.7	1	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene VPH2 [Source:SGD;Acc:S000001601]
K	YKL119C	VPH2	350	-154.4	4	Integral membrane protein required for vacuolar H+-ATPase (V-ATPase) function, although not an actual component of the V-ATPase complex; functions in the assembly of the V-ATPase; localized to the endoplasmic reticulum (ER) [Source:SGD;Acc:S000001602]
K	YKL120W	OAC1	885	-637.6	4	Mitochondrial inner membrane transporter, transports oxaloacetate, sulfate, thiosulfate, and isopropylmalate; member of the mitochondrial carrier family [Source:SGD;Acc:S000001603]
K	YKL121W	DGR2	176	-189.7	4	Protein of unknown function; null mutant is resistant to 2-deoxy-D-glucose and displays abnormally elongated buds [Source:SGD;Acc:S000001604]
K	YKL122C	SRP21	860	-90.8	4	Subunit of the signal recognition particle (SRP), which functions in protein targeting to the endoplasmic reticulum membrane; not found in mammalian SRP; forms a pre-SRP structure in the nucleolus that is translocated to the cytoplasm [Source:SGD;Acc:S000001605]
K	YKL123W	YKL123W	2	-1.8	1	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene SSH4 [Source:SGD;Acc:S000001606]
K	YKL124W	SSH4	255	-84.1	4	Specificity factor required for Rsp5p-dependent ubiquitination and sorting of cargo proteins at the multivesicular body; identified as a high-copy suppressor of a SHR3 deletion, increasing steady-state levels of amino acid permeases [Source:SGD;Acc:S000001607]
K	YKL125W	RRN3	85	-62.5	4	Protein required for transcription of rDNA by RNA polymerase I; transcription factor independent of DNA template; involved in recruitment of RNA polymerase I to rDNA; structure reveals unique HEAT repeat fold and a surface serine patch; phosphorylat   serine patch impairs cell growth and reduces RNA polymerase I binding in vitro and RNA polymerase I recruitment to the rDNA gene in vivo [Source:SGD;Acc:S000001608]
K	YKL126W	YPK1	1712	-1800.5	4	Serine/threonine protein kinase that phosphorylates and downregulates flippase activator Fpk1p; mutations affect receptor-mediated endocytosis and sphingolipid-mediated and cell integrity signaling pathways; homolog of mammalian kinase SGK [Source:SGD;Acc:S000001609]
K	YKL127W	PGM1	2465	-676.7	4	Phosphoglucomutase, minor isoform; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism [Source:SGD;Acc:S000001610]
K	YKL128C	PMU1	778	-236.3	4	Putative phosphomutase, contains a region homologous to the active site of phosphomutases; overexpression suppresses the histidine auxotrophy of an ade3 ade16 ade17 triple mutant and the temperature sensitivity of a tps2 mutant [Source:SGD;Acc:S000001611]
K	YKL129C	MYO3	1832	-952.2	4	One of two type I myosins; localizes to actin cortical patches; deletion of MYO3 has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization [Source:SGD;Acc:S000001612]
K	YKL130C	SHE2	445	-135.9	4	RNA-binding protein that binds specific mRNAs and interacts with She3p; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud [Source:SGD;Acc:S000001613]
K	YKL131W	YKL131W	12	-1.8	1	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001614]
K	YKL132C	RMA1	22	-24.9	2	Putative dihydrofolate synthetase; has similarity to Fol3p and to E. coli folylpolyglutamate synthetase/dihydrofolate synthetase; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001615]
K	YKL133C	YKL133C	47	-156.2	4	Putative protein of unknown function; has similarity to Mgr3p, but unlike MGR3, is not required for growth of cells lacking the mitochondrial genome (null mutation does not confer a petite-negative phenotype) [Source:SGD;Acc:S000001616]
K	YKL134C	OCT1	290	-360.1	4	Mitochondrial intermediate peptidase, cleaves destabilizing N-terminal residues of a subset of proteins upon import, after their cleavage by mitochondrial processing peptidase (Mas1p-Mas2p); may contribute to mitochondrial iron homeostasis [Source:SGD;Acc:S000001617]
K	YKL135C	APL2	890	-534.4	4	Beta-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting [Source:SGD;Acc:S000001618]
K	YKL136W	YKL136W	1	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF APL2/YKL135C [Source:SGD;Acc:S000001619]
K	YKL137W	CMC1	372	-72.8	4	Evolutionarily conserved copper-binding protein of the mitochondrial intermembrane space, may be involved in delivering copper from the matrix to the cytochrome c oxidase complex; contains a twin CX9C motif [Source:SGD;Acc:S000001620]
K	YKL138C	MRPL31	173	-47	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000001621]
K	YKL138C-A	HSK3	88	-47.4	4	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis [Source:SGD;Acc:S000028421]
K	YKL139W	CTK1	383	-766.5	4	Catalytic (alpha) subunit of C-terminal domain kinase I (CTDK-I); phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity; similar to the Dr  la dCDK12 and human CDK12 and probably CDK13 [Source:SGD;Acc:S000001622]
K	YKL140W	TGL1	936	-303.4	4	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes [Source:SGD;Acc:S000001623]
K	YKL141W	SDH3	594	-109.1	4	Cytochrome b subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain [Source:SGD;Acc:S000001624]
K	YKL142W	MRP8	1672	-325.2	4	Protein of unknown function; undergoes sumoylation; transcription induced under cell wall stress; protein levels are reduced under anaerobic conditions; originally thought to be a mitochondrial ribosomal protein based on sequence analysis [Source:SGD;Acc:S000001625]
K	YKL143W	LTV1	612	-235.9	4	Component of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; required for ribosomal small subunit export from nucleus; required for growth at low temperature [Source:SGD;Acc:S000001626]
K	YKL144C	RPC25	260	-87.9	4	RNA polymerase III subunit C25, required for transcription initiation; forms a heterodimer with Rpc17p; paralog of Rpb7p [Source:SGD;Acc:S000001627]
K	YKL145W	RPT1	2309	-524	4	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for optimal CDC20 transcription; interacts with Rpn12p and Ubr1p; mutant has aneuploidy tolerance [Source:SGD;Acc:S000001628]
K	YKL145W-A	YKL145W-A	4	-1.3	1	Dubious open reading frame, unlikely to encode a protein; completely overlaps the verified essential gene RPT1; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028841]
K	YKL146W	AVT3	495	-133.9	4	Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters [Source:SGD;Acc:S000001629]
K	YKL147C	YKL147C	9	-2.7	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene AVT3 [Source:SGD;Acc:S000001630]
K	YKL148C	SDH1	1667	-908.7	4	Flavoprotein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain [Source:SGD;Acc:S000001631]
K	YKL149C	DBR1	124	-83.3	4	RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition [Source:SGD;Acc:S000001632]
K	YKL150W	MCR1	1741	-1237	4	Mitochondrial NADH-cytochrome b5 reductase, involved in ergosterol biosynthesis [Source:SGD;Acc:S000001633]
K	YKL151C	YKL151C	828	-467.2	4	NADHX dehydratase; converts (S)-NADHX to NADH in an ATP-dependent manner; homologous to Carkd in mammals, and the C-terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; YKL151C promoter contains STREs (stre  ponse elements) and expression is induced by heat shock or methyl methanesulfonate; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001634]
K	YKL152C	GPM1	5537	-1231.3	4	Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis [Source:SGD;Acc:S000001635]
K	YKL153W	YKL153W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant [Source:SGD;Acc:S000001636]
K	YKL154W	SRP102	566	-218.8	4	Signal recognition particle (SRP) receptor beta subunit; involved in SRP-dependent protein targeting; anchors the alpha subunit, Srp101p to the ER membrane [Source:SGD;Acc:S000001637]
K	YKL155C	RSM22	258	-269.7	4	Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase [Source:SGD;Acc:S000001638]
K	YKL156C-A	YKL156C-A	2	-1.4	1	Dubious open reading frame unlikely to encode a protein; completely overlaps the verified gene RPS27A; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028668]
K	YKL156W	RPS27A	2972	-162.4	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps27Bp and has similarity to rat S27 ribosomal protein [Source:SGD;Acc:S000001639]
K	YKL157W	APE2	2516	-1475.7	4	Aminopeptidase yscII; may have a role in obtaining leucine from dipeptide substrates; sequence coordinates have changed since RT-PCR analysis showed that the adjacent ORF YKL158W comprises the 5' exon of APE2/YKL157W [Source:SGD;Acc:S000001640]
K	YKL159C	RCN1	327	-102.8	4	Protein involved in calcineurin regulation during calcium signaling; has similarity to H. sapiens DSCR1 which is found in the Down Syndrome candidate region [Source:SGD;Acc:S000001642]
K	YKL160W	ELF1	522	-71.7	4	Transcription elongation factor that contains a conserved zinc finger domain; implicated in the maintenance of proper chromatin structure in actively transcribed regions; deletion inhibits Brome mosaic virus (BMV) gene expression [Source:SGD;Acc:S000001643]
K	YKL161C	KDX1	34	-796.4	4	Protein kinase implicated in the Slt2p mitogen-activated (MAP) kinase signaling pathway; interacts with numerous components in the mating pheromone and CWI MAPK pathways; associates with Rlm1p [Source:SGD;Acc:S000001644]
K	YKL162C	YKL162C	73	-81.1	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion [Source:SGD;Acc:S000001645]
K	YKL162C-A	YKL162C-A	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007244]
K	YKL163W	PIR3	747	-87.1	4	O-glycosylated covalently-bound cell wall protein required for cell wall stability; expression is cell cycle regulated, peaking in M/G1 and also subject to regulation by the cell integrity pathway [Source:SGD;Acc:S000001646]
K	YKL164C	PIR1	1014	-110.4	4	O-glycosylated protein required for cell wall stability; attached to the cell wall via beta-1,3-glucan; mediates mitochondrial translocation of Apn1p; expression regulated by the cell integrity pathway and by Swi5p during the cell cycle [Source:SGD;Acc:S000001647]
K	YKL165C	MCD4	701	-263.4	4	Protein involved in glycosylphosphatidylinositol (GPI) anchor synthesis; multimembrane-spanning protein that localizes to the endoplasmic reticulum; highly conserved among eukaryotes [Source:SGD;Acc:S000001648]
K	YKL165C-A	YKL165C-A	3	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007617]
K	YKL166C	TPK3	653	-697.3	4	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase [Source:SGD;Acc:S000001649]
K	YKL167C	MRP49	263	-82.3	4	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation [Source:SGD;Acc:S000001650]
K	YKL168C	KKQ8	372	-478.7	4	Putative serine/threonine protein kinase with unknown cellular role [Source:SGD;Acc:S000001651]
K	YKL169C	YKL169C	5	-3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL38 [Source:SGD;Acc:S000001652]
K	YKL170W	MRPL38	349	-152.8	4	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels [Source:SGD;Acc:S000001653]
K	YKL171W	NNK1	246	-1988.6	4	Protein kinase; implicated in proteasome function; interacts with TORC1, Ure2 and Gdh2; overexpression leads to hypersensitivity to rapamycin and nuclear accumulation of Gln3; epitope-tagged protein localizes to the cytoplasm [Source:SGD;Acc:S000001654]
K	YKL172W	EBP2	1662	-409.1	4	Required for 25S rRNA maturation and 60S ribosomal subunit assembly; localizes to the nucleolus and in foci along nuclear periphery; constituent of 66S pre-ribosomal particles; cooperates with Rrs1p and Mps3p to mediate telomere clustering by bindin  p, but is not involved in telomere tethering [Source:SGD;Acc:S000001655]
K	YKL173W	SNU114	853	-622	4	GTPase component of U5 snRNP involved in mRNA splicing via spliceosome; binds directly to U5 snRNA; proposed to be involved in conformational changes of the spliceosome; similarity to ribosomal translocation factor EF-2 [Source:SGD;Acc:S000001656]
K	YKL174C	TPO5	204	-85.3	4	Protein involved in excretion of putrescine and spermidine; putative polyamine transporter in the Golgi or post-Golgi vesicles [Source:SGD;Acc:S000001657]
K	YKL175W	ZRT3	584	-155.2	4	Vacuolar membrane zinc transporter, transports zinc from storage in the vacuole to the cytoplasm when needed; transcription is induced under conditions of zinc deficiency [Source:SGD;Acc:S000001658]
K	YKL176C	LST4	199	-164.3	4	Protein possibly involved in a post-Golgi secretory pathway; required for the transport of nitrogen-regulated amino acid permease Gap1p from the Golgi to the cell surface [Source:SGD;Acc:S000001659]
K	YKL177W	YKL177W	2	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene STE3 [Source:SGD;Acc:S000001660]
K	YKL178C	STE3	87	-54.8	4	Receptor for a factor pheromone, couples to MAP kinase cascade to mediate pheromone response; transcribed in alpha cells and required for mating by alpha cells, ligand bound receptors endocytosed and recycled to the plasma membrane; GPCR [Source:SGD;Acc:S000001661]
K	YKL179C	COY1	1128	-439.9	4	Golgi membrane protein with similarity to mammalian CASP; genetic interactions with GOS1 (encoding a Golgi snare protein) suggest a role in Golgi function [Source:SGD;Acc:S000001662]
K	YKL180W	RPL17A	4365	-830.2	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl17Bp and has similarity to E. coli L22 and rat L17 ribosomal proteins; copurifies with the Dam1 complex (aka DASH complex) [Source:SGD;Acc:S000001663]
K	YKL181W	PRS1	1779	-448	4	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes [Source:SGD;Acc:S000001664]
K	YKL182W	FAS1	4714	-5999	4	Beta subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains acetyltransacylase, dehydratase, enoyl reductase, malonyl transacylase, and palmitoyl transacylase activities [Source:SGD;Acc:S000001665]
K	YKL183C-A	YKL183C-A	0	nf	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028558]
K	YKL183W	LOT5	92	-29	4	Protein of unknown function; gene expression increases in cultures shifted to a lower temperature [Source:SGD;Acc:S000001666]
K	YKL184W	SPE1	365	-257.9	4	Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation [Source:SGD;Acc:S000001667]
K	YKL185W	ASH1	302	-286.1	4	Zinc-finger inhibitor of HO transcription; mRNA is localized and translated in the distal tip of anaphase cells, resulting in accumulation of Ash1p in daughter cell nuclei and inhibition of HO expression; potential Cdc28p substrate [Source:SGD;Acc:S000001668]
K	YKL186C	MTR2	632	-284.5	4	mRNA transport regulator, essential nuclear protein; Mex67p and Mtr2p form a mRNA export complex which binds to RNA [Source:SGD;Acc:S000001669]
K	YKL187C	FAT3	116	-236.3	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001670]
K	YKL188C	PXA2	127	-181.2	4	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins [Source:SGD;Acc:S000001671]
K	YKL189W	HYM1	172	-165.2	4	Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with Kic1p and Sog2p, localizes to sites of polarized growth during budding and during the mating response [Source:SGD;Acc:S000001672]
K	YKL190W	CNB1	802	-342.3	4	Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1 [Source:SGD;Acc:S000001673]
K	YKL191W	DPH2	686	-287.9	4	Protein required, along with Dph1p, Kti11p, Jjj3p, and Dph5p, for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); may act in a complex with Dph1p and Kti11p [Source:SGD;Acc:S000001674]
K	YKL192C	ACP1	1450	-159.9	4	Mitochondrial matrix acyl carrier protein, involved in biosynthesis of octanoate, which is a precursor to lipoic acid; activated by phosphopantetheinylation catalyzed by Ppt2p [Source:SGD;Acc:S000001675]
K	YKL193C	SDS22	1169	-466.3	4	Conserved nuclear regulatory subunit of Glc7p type 1 protein serine-threonine phosphatase (PP1), functions positively with Glc7p to promote dephosphorylation of nuclear substrates required for chromosome transmission during mitosis [Source:SGD;Acc:S000001676]
K	YKL194C	MST1	368	-278.8	4	Mitochondrial threonyl-tRNA synthetase [Source:SGD;Acc:S000001677]
K	YKL195W	MIA40	1473	-383.1	4	Essential protein of the mitochondrial intermembrane space (IMS); promotes retention of newly imported proteins; may do so by stabilizing client protein folding as part of a disulfide relay system or transferring metal to client proteins [Source:SGD;Acc:S000001678]
K	YKL196C	YKT6	1944	-586.9	4	Vesicle membrane protein (v-SNARE) with acyltransferase activity; involved in trafficking to and within the Golgi, endocytic trafficking to the vacuole, and vacuolar fusion; membrane localization due to prenylation at the carboxy-terminus [Source:SGD;Acc:S000001679]
K	YKL197C	PEX1	316	-277.3	4	AAA-peroxin that heterodimerizes with AAA-peroxin Pex6p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol; induced by oleic acid and upregulated during anaerobiosis [Source:SGD;Acc:S000001680]
K	YKL198C	PTK1	80	-293	4	Putative serine/threonine protein kinase that regulates spermine uptake; involved in polyamine transport; possible mitochondrial protein [Source:SGD;Acc:S000001681]
K	YKL201C	MNN4	152	-322	4	Putative positive regulator of mannosylphosphate transferase (Mnn6p), involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases [Source:SGD;Acc:S000001684]
K	YKL202W	YKL202W	2	-2.7	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001685]
K	YKL203C	TOR2	668	-870	4	PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis [Source:SGD;Acc:S000001686]
K	YKL204W	EAP1	1439	-487.7	4	eIF4E-associated protein, competes with eIF4G for binding to eIF4E; inhibits cap-dependent translation; functions independently of eIF4E to maintain genetic stability; plays a role in cell growth, implicated in the TOR signaling cascade [Source:SGD;Acc:S000001687]
K	YKL205W	LOS1	579	-332.1	4	Nuclear pore protein involved in nuclear export of pre-tRNA and in re-export of mature tRNAs after their retrograde import from the cytoplasm [Source:SGD;Acc:S000001688]
K	YKL206C	ADD66	367	-140.5	4	Protein involved in 20S proteasome assembly; forms a heterodimer with Pba1p that binds to proteasome precursors; similar to human PAC2 constituent of the PAC1-PAC2 complex involved in proteasome assembly [Source:SGD;Acc:S000001689]
K	YKL207W	EMC3	198	-124.5	4	Member of a transmembrane complex required for efficient folding of proteins in the ER; required for respiratory growth; null mutant displays induction of the unfolded protein response [Source:SGD;Acc:S000001690]
K	YKL208W	CBT1	33	-42.7	4	Protein involved in 5' end processing of mitochondrial COB, 15S_rRNA, and RPM1 transcripts; may also have a role in 3' end processing of the COB pre-mRNA; displays genetic interaction with cell cycle-regulated kinase Dbf2p [Source:SGD;Acc:S000001691]
K	YKL209C	STE6	188	-268.9	4	Plasma membrane ATP-binding cassette (ABC) transporter required for the export of a-factor, catalyzes ATP hydrolysis coupled to a-factor transport; contains 12 transmembrane domains and two ATP binding domains; expressed only in MATa cells [Source:SGD;Acc:S000001692]
K	YKL210W	UBA1	3152	-1521	4	Ubiquitin activating enzyme (E1), involved in ubiquitin-mediated protein degradation and essential for viability [Source:SGD;Acc:S000001693]
K	YKL211C	TRP3	1666	-544.6	4	Bifunctional enzyme exhibiting both indole-3-glycerol-phosphate synthase and anthranilate synthase activities, forms multifunctional hetero-oligomeric anthranilate synthase:indole-3-glycerol phosphate synthase enzyme complex with Trp2p [Source:SGD;Acc:S000001694]
K	YKL212W	SAC1	2445	-873.5	4	Phosphatidylinositol phosphate (PtdInsP) phosphatase involved in hydrolysis of PtdIns[4]P; transmembrane protein localizes to ER and Golgi; involved in protein trafficking and processing, secretion, and cell wall maintenance [Source:SGD;Acc:S000001695]
K	YKL213C	DOA1	1098	-758.5	4	WD repeat protein required for ubiquitin-mediated protein degradation, forms complex with Cdc48p, plays a role in controlling cellular ubiquitin concentration; also promotes efficient NHEJ in postdiauxic/stationary phase [Source:SGD;Acc:S000001696]
K	YKL214C	YRA2	685	-226.4	4	Member of the REF (RNA and export factor binding proteins) family; when overexpressed, can substitute for the function of Yra1p in export of poly(A)+ mRNA from the nucleus [Source:SGD;Acc:S000001697]
K	YKL215C	OXP1	1148	-967	4	5-oxoprolinase; enzyme is ATP-dependent and functions as a dimer; similar to mouse Oplah gene; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001698]
K	YKL216W	URA1	2353	-766.3	4	Dihydroorotate dehydrogenase, catalyzes the fourth enzymatic step in the de novo biosynthesis of pyrimidines, converting dihydroorotic acid into orotic acid [Source:SGD;Acc:S000001699]
K	YKL217W	JEN1	238	-476.2	4	Monocarboxylate/proton symporter of the plasma membrane; transport activity is dependent on the pH gradient across the membrane; mediates high-affinity uptake of carbon sources lactate, pyuvate, and acetate, and also of the micronutrient selenite, w  tructure mimics that of monocarboxylates; expression and localization are tightly regulated, with transcription repression, mRNA degradation, and protein endocytosis and degradation all occurring in the presence of glucose [Source:SGD;Acc:S000001700]
K	YKL218C	SRY1	457	-321.7	4	3-hydroxyaspartate dehydratase, deaminates L-threo-3-hydroxyaspartate to form oxaloacetate and ammonia; required in the presence of hydroxyaspartate; highly similar to mouse serine racemase (Srr) but has no serine racemase activity [Source:SGD;Acc:S000001701]
K	YKL219W	COS9	64	-102.8	4	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000001702]
K	YKL220C	FRE2	20	-28.5	4	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels [Source:SGD;Acc:S000001703]
K	YKL221W	MCH2	8	-4.2	2	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport [Source:SGD;Acc:S000001704]
K	YKL222C	YKL222C	31	-5.2	2	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine [Source:SGD;Acc:S000001705]
K	YKL223W	YKL223W	9	-3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001706]
K	YKL224C	PAU16	5	-9.3	2	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions [Source:SGD;Acc:S000001707]
K	YKL225W	YKL225W	1	-1.8	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001708]
K	YKR001C	VPS1	3221	-5999	4	Dynamin-like GTPase required for vacuolar sorting; also involved in actin cytoskeleton organization, endocytosis, late Golgi-retention of some proteins, regulation of peroxisome biogenesis [Source:SGD;Acc:S000001709]
K	YKR002W	PAP1	775	-361.3	4	Poly(A) polymerase, one of three factors required for mRNA 3'-end polyadenylation, forms multiprotein complex with polyadenylation factor I (PF I), also required for mRNA nuclear export; may also polyadenylate rRNAs; required for gene looping [Source:SGD;Acc:S000001710]
K	YKR003W	OSH6	978	-343.5	4	Member of an oxysterol-binding protein family with overlapping, redundant functions in sterol metabolism and which collectively perform a function essential for viability; GFP-fusion protein localizes to the cell periphery [Source:SGD;Acc:S000001711]
K	YKR004C	ECM9	50	-60.5	4	Non-essential protein of unknown function [Source:SGD;Acc:S000001712]
K	YKR005C	YKR005C	12	-11.9	2	Putative protein of unknown function [Source:SGD;Acc:S000001713]
K	YKR006C	MRPL13	995	-192.8	4	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation [Source:SGD;Acc:S000001714]
K	YKR007W	MEH1	368	-113.9	4	Component of the EGO complex, which is involved in the regulation of microautophagy, and of the GSE complex, which is required for proper sorting of amino acid permease Gap1p; loss results in a defect in vacuolar acidification [Source:SGD;Acc:S000001715]
K	YKR008W	RSC4	1061	-467.8	4	Component of the RSC chromatin remodeling complex; found in close proximity to nucleosomal DNA; displaced from the surface of nucleosomal DNA after chromatin remodeling; acetylated (K25) by Gcn5p, altering replication stress tolerance; contains tand  modomains that recognize histone H3 acetylated on K14 (H3K14ac) by Gcn5p [Source:SGD;Acc:S000001716]
K	YKR009C	FOX2	490	-1227	4	Multifunctional enzyme of the peroxisomal fatty acid beta-oxidation pathway; has 3-hydroxyacyl-CoA dehydrogenase and enoyl-CoA hydratase activities [Source:SGD;Acc:S000001717]
K	YKR010C	TOF2	335	-302.5	4	Protein required for rDNA silencing and mitotic rDNA condensation; stimulates Cdc14p phosphatase activity and biphasic release to promote rDNA repeat segregation; required for condensin recruitment to the replication fork barrier site [Source:SGD;Acc:S000001718]
K	YKR011C	YKR011C	37	-108	3	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus [Source:SGD;Acc:S000001719]
K	YKR012C	YKR012C	3	-1.7	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PRY2 [Source:SGD;Acc:S000001720]
K	YKR013W	PRY2	153	-40.4	4	Protein of unknown function [Source:SGD;Acc:S000001721]
K	YKR014C	YPT52	1607	-499.1	4	Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis [Source:SGD;Acc:S000001722]
K	YKR015C	YKR015C	22	-4.6	2	Putative protein of unknown function [Source:SGD;Acc:S000001723]
K	YKR016W	MIC60	1642	-636.9	4	Mitochondrial inner membrane protein, ortholog of mammalian mitofilin; involved in import of intermembrane space (IMS) proteins, probably by positioning Mia40p relative to the TOM complex to receive incoming proteins; also has an essential role in t  ntenance of crista junctions and inner membrane architecture, as a component of the mitochondrial inner membrane organizing system (MICOS, MitOS or MINOS), a scaffold-like structure on the IMS side of the inner membrane [Source:SGD;Acc:S000001724]
K	YKR017C	HEL1	36	-126.3	4	Putative protein of unknown function; contains a RING finger motif [Source:SGD;Acc:S000001725]
K	YKR018C	YKR018C	1713	-924.7	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000001726]
K	YKR019C	IRS4	200	-116.6	4	EH domain-containing protein involved in regulating phosphatidylinositol 4,5-bisphosphate levels and autophagy; Irs4p and Tax4p bind and activate the PtdIns phosphatase Inp51p; Irs4p and Tax4p are involved in localizing Atg17p to the PAS [Source:SGD;Acc:S000001727]
K	YKR020W	VPS51	205	-87.8	4	Component of the GARP (Golgi-associated retrograde protein) complex, Vps51p-Vps52p-Vps53p-Vps54p, which is required for the recycling of proteins from endosomes to the late Golgi; links the (VFT/GARP) complex to the SNARE Tlg1p [Source:SGD;Acc:S000001728]
K	YKR021W	ALY1	538	-2471.5	4	Alpha arrestin that controls nutrient-mediated intracellular sorting of permease Gap1p; interacts with AP-1 subunit Apl4p; may regulate endocytosis of plasma membrane proteins by recruiting ubiquitin ligase Rsp5p to plasma membrane targets [Source:SGD;Acc:S000001729]
K	YKR022C	NTR2	82	-58.7	4	Essential protein that forms a dimer with Ntr1p; also forms a trimer, with Ntr2p and the DExD/H-box RNA helicase Prp43p, that is involved in spliceosome disassembly [Source:SGD;Acc:S000001730]
K	YKR023W	YKR023W	456	-321.6	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001731]
K	YKR024C	DBP7	671	-327.4	4	Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions [Source:SGD;Acc:S000001732]
K	YKR025W	RPC37	566	-213.9	4	RNA polymerase III subunit C37 [Source:SGD;Acc:S000001733]
K	YKR026C	GCN3	895	-293.9	4	Alpha subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a positive regulator of GCN4 expression [Source:SGD;Acc:S000001734]
K	YKR027W	BCH2	209	-182.7	4	Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane [Source:SGD;Acc:S000001735]
K	YKR028W	SAP190	789	-683.1	4	Protein that forms a complex with the Sit4p protein phosphatase and is required for its function; member of a family of similar proteins including Sap4p, Sap155p, and Sap185p [Source:SGD;Acc:S000001736]
K	YKR029C	SET3	495	-305	4	Defining member of the SET3 histone deacetylase complex which is a meiosis-specific repressor of sporulation genes; necessary for efficient transcription by RNAPII; one of two yeast proteins that contains both SET and PHD domains [Source:SGD;Acc:S000001737]
K	YKR030W	GMH1	112	-48.8	4	Golgi membrane protein of unknown function, interacts with Gea1p and Gea2p; required for localization of Gea2p; computational analysis suggests a possible role in either cell wall synthesis or protein-vacuolar targeting [Source:SGD;Acc:S000001738]
K	YKR031C	SPO14	503	-463.1	4	Phospholipase D; catalyzes the hydrolysis of phosphatidylcholine, producing choline and phosphatidic acid; involved in Sec14p-independent secretion; required for meiosis and spore formation; differently regulated in secretion and meiosis; participat  transcription initiation and/or early elongation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions [Source:SGD;Acc:S000001739]
K	YKR032W	YKR032W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001740]
K	YKR033C	YKR033C	11	-8.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene DAL80 [Source:SGD;Acc:S000001741]
K	YKR034W	DAL80	20	-23.2	4	Negative regulator of genes in multiple nitrogen degradation pathways; expression is regulated by nitrogen levels and by Gln3p; member of the GATA-binding family, forms homodimers and heterodimers with Deh1p [Source:SGD;Acc:S000001742]
K	YKR035C	OPI8	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene DID2/YKR035W-A [Source:SGD;Acc:S000001743]
K	YKR035W-A	DID2	904	-140.6	4	Class E protein of the vacuolar protein-sorting (Vps) pathway; binds Vps4p and directs it to dissociate ESCRT-III complexes; forms a functional and physical complex with Ist1p; human ortholog may be altered in breast tumors [Source:SGD;Acc:S000006435]
K	YKR036C	CAF4	218	-192.6	4	WD40 repeat-containing protein associated with the CCR4-NOT complex, interacts in a Ccr4p-dependent manner with Ssn2p; also interacts with Fis1p, Mdv1p and Dnm1p and plays a role in mitochondrial fission [Source:SGD;Acc:S000001744]
K	YKR037C	SPC34	152	-99.6	4	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body [Source:SGD;Acc:S000001745]
K	YKR038C	KAE1	464	-231.5	4	Highly conserved ATPase of HSP70/DnaK family; component of the EKC/KEOPS complex with Bud32p, Cgi121p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription [Source:SGD;Acc:S000001746]
K	YKR039W	GAP1	464	-135.4	4	General amino acid permease; Gap1p senses the presence of amino acid substrates to regulate localization to the plasma membrane when needed [Source:SGD;Acc:S000001747]
K	YKR040C	YKR040C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W [Source:SGD;Acc:S000001748]
K	YKR041W	YKR041W	23	-20.3	2	Protein of unknown function; localizes to the mitotic spindle; overexpression of YKR041W affects endocytic protein trafficking [Source:SGD;Acc:S000001749]
K	YKR042W	UTH1	734	-348	4	Mitochondrial outer membrane and cell wall localized SUN family member involved in cell wall biogenesis and required for mitochondrial autophagy; involved in the oxidative stress response, life span during starvation, and cell death [Source:SGD;Acc:S000001750]
K	YKR043C	SHB17	1613	-330.3	4	Sedoheptulose bisphosphatase involved in riboneogenesis; dephosphorylates sedoheptulose 1,7-bisphosphate, which is converted via the nonoxidative pentose phosphate pathway to ribose-5-phosphate; facilitates the conversion of glycolytic intermediates  ntose phosphate units; also has fructose 1,6-bisphosphatase activity but this is probably not biologically relevant, since deletion does not affect FBP levels; GFP-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000001751]
K	YKR044W	UIP5	33	-41	4	Protein of unknown function that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates [Source:SGD;Acc:S000001752]
K	YKR045C	YKR045C	41	-35.1	4	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm [Source:SGD;Acc:S000001753]
K	YKR046C	PET10	1434	-1068.5	4	Protein of unknown function that co-purifies with lipid particles; expression pattern suggests a role in respiratory growth; computational analysis of large-scale protein-protein interaction data suggests a role in ATP/ADP exchange [Source:SGD;Acc:S000001754]
K	YKR047W	YKR047W	2	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NAP1 [Source:SGD;Acc:S000001755]
K	YKR048C	NAP1	2684	-734	4	Protein that interacts with mitotic cyclin Clb2p; required for the regulation of microtubule dynamics during mitosis; controls bud morphogenesis; involved in the transport of H2A and H2B histones to the nucleus; phosphorylated by CK2 [Source:SGD;Acc:S000001756]
K	YKR049C	FMP46	505	-130.7	4	Putative redox protein containing a thioredoxin fold; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001757]
K	YKR050W	TRK2	36	-8.7	2	Component of the Trk1p-Trk2p potassium transport system [Source:SGD;Acc:S000001758]
K	YKR051W	YKR051W	43	-28.6	3	Putative protein of unknown function [Source:SGD;Acc:S000001759]
K	YKR052C	MRS4	180	-81.5	4	Iron transporter that mediates Fe2+ transport across the inner mitochondrial membrane; mitochondrial carrier family member, similar to and functionally redundant with Mrs3p; active under low-iron conditions; may transport other cations [Source:SGD;Acc:S000001760]
K	YKR053C	YSR3	31	-20.7	2	Dihydrosphingosine 1-phosphate phosphatase, membrane protein involved in sphingolipid metabolism; has similarity to Lcb3p [Source:SGD;Acc:S000001761]
K	YKR054C	DYN1	355	-765.4	4	Cytoplasmic heavy chain dynein, microtubule motor protein, required for anaphase spindle elongation; involved in spindle assembly, chromosome movement, and spindle orientation during cell division, targeted to microtubule tips by Pac1p [Source:SGD;Acc:S000001762]
K	YKR055W	RHO4	291	-201.2	4	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely to be involved in the establishment of cell polarity [Source:SGD;Acc:S000001763]
K	YKR056W	TRM2	656	-329.8	4	tRNA methyltransferase, 5-methylates the uridine residue at position 54 of tRNAs and may also have a role in tRNA stabilization or maturation; endo-exonuclease with a role in DNA repair [Source:SGD;Acc:S000001764]
K	YKR057W	RPS21A	3513	-280	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps21Bp and has similarity to rat S21 ribosomal protein [Source:SGD;Acc:S000001765]
K	YKR058W	GLG1	159	-353.1	4	Self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin [Source:SGD;Acc:S000001766]
K	YKR059W	TIF1	4901	-1563.8	4	Translation initiation factor eIF4A, identical to Tif2p; DEA(D/H)-box RNA helicase that couples ATPase activity to RNA binding and unwinding; forms a dumbbell structure of two compact domains connected by a linker; interacts with eIF4G [Source:SGD;Acc:S000001767]
K	YKR060W	UTP30	463	-160.5	4	Subunit of U3-containing 90S preribosome complex involved in production of 18S rRNA and assembly of small ribosomal subunit [Source:SGD;Acc:S000001768]
K	YKR061W	KTR2	36	-61	4	Mannosyltransferase involved in N-linked protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family [Source:SGD;Acc:S000001769]
K	YKR062W	TFA2	711	-277.8	4	TFIIE small subunit, involved in RNA polymerase II transcription initiation [Source:SGD;Acc:S000001770]
K	YKR063C	LAS1	140	-204.4	4	Protein required for pre-rRNA processing at both ends of ITS2; may coordinate the action of the Rat1p-Rai1p exoRNAse; required for the G1/S transition of the cell cycle; human ortholog is Las1L; mutants require the SSD1-v allele for viability [Source:SGD;Acc:S000001771]
K	YKR064W	OAF3	82	-102.5	4	Putative transcriptional repressor with Zn(2)-Cys(6) finger; negatively regulates transcription in response to oleate levels, based on mutant phenotype and localization to oleate-responsive promoters; the authentic, non-tagged protein is detected in  y purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001772]
K	YKR065C	PAM17	630	-188.7	4	Constituent of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); proposed alternatively to be a component of the import motor (PAM complex) or to interact with and modulate the core TIM23 complex [Source:SGD;Acc:S000001773]
K	YKR066C	CCP1	1596	-770.1	4	Mitochondrial cytochrome-c peroxidase; degrades reactive oxygen species in mitochondria, involved in the response to oxidative stress [Source:SGD;Acc:S000001774]
K	YKR067W	GPT2	1141	-536.3	4	Glycerol-3-phosphate/dihydroxyacetone phosphate dual substrate-specific sn-1 acyltransferase located in lipid particles and the ER; involved in the stepwise acylation of glycerol-3-phosphate and dihydroxyacetone in lipid biosynthesis [Source:SGD;Acc:S000001775]
K	YKR068C	BET3	438	-89.3	4	Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex [Source:SGD;Acc:S000001776]
K	YKR069W	MET1	158	-184.7	4	S-adenosyl-L-methionine uroporphyrinogen III transmethylase, involved in the biosynthesis of siroheme, a prosthetic group used by sulfite reductase; required for sulfate assimilation and methionine biosynthesis [Source:SGD;Acc:S000001777]
K	YKR070W	YKR070W	628	-232.5	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000001778]
K	YKR071C	DRE2	1130	-346.2	4	Conserved component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; contains an Fe-S cluster that receives electrons from NADPH via the action of Tah18p; ortholog of human Ciapin1 [Source:SGD;Acc:S000001779]
K	YKR072C	SIS2	976	-371.5	4	Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis [Source:SGD;Acc:S000001780]
K	YKR073C	YKR073C	1	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000001781]
K	YKR074W	AIM29	578	-111.5	4	Putative protein of unknown function; epitope-tagged protein localizes to the cytoplasm; YKR074W is not an essential gene; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000001782]
K	YKR075C	YKR075C	30	-69.8	4	Protein of unknown function; similar to YOR062Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000001783]
K	YKR075W-A	YKR075W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein; completely overlaps the uncharacterized gene YKR075C; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028669]
K	YKR076W	ECM4	403	-437.1	4	Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000001784]
K	YKR077W	MSA2	180	-37.2	4	Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation [Source:SGD;Acc:S000001785]
K	YKR078W	YKR078W	104	-133.4	4	Cytoplasmic protein of unknown function, has similarity to Vps5p; potential Cdc28p substrate; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) [Source:SGD;Acc:S000001786]
K	YKR079C	TRZ1	422	-334.8	4	tRNA 3'-end processing endonuclease tRNase Z; also localized to mitochondria and interacts genetically with Rex2 exonuclease; homolog of the human candidate prostate cancer susceptibility gene ELAC2 [Source:SGD;Acc:S000001787]
K	YKR080W	MTD1	1196	-864.1	4	NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline [Source:SGD;Acc:S000001788]
K	YKR081C	RPF2	1285	-277.6	4	Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles [Source:SGD;Acc:S000001789]
K	YKR082W	NUP133	1284	-1346.4	4	Subunit of the Nup84p subcomplex of the nuclear pore complex (NPC); localizes to both sides of the NPC, required to establish a normal nucleocytoplasmic concentration gradient of the GTPase Gsp1p; required also for transcription elongation as demons   by the G-less-based run-on (GLRO) assay [Source:SGD;Acc:S000001790]
K	YKR083C	DAD2	108	-68.3	4	Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; is transferred to the kinetochore prior to mitosis [Source:SGD;Acc:S000001791]
K	YKR084C	HBS1	985	-334.4	4	GTPase with similarity to translation release factors; together with binding partner Dom34p, facilitates ribosomal subunit dissociation and peptidyl-tRNA release when translation is stalled; genetically implicated in mRNA no-go decay [Source:SGD;Acc:S000001792]
K	YKR085C	MRPL20	482	-116	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000001793]
K	YKR086W	PRP16	274	-229.3	4	DEAH-box RNA helicase involved in second catalytic step of splicing; exhibits ATP-dependent RNA unwinding activity; mediates the release of Yju2p and Cwc25p in the second step; in the absence of ATP, stabilizes the binding of Cwc25p to the spliceoso  the first catalytic step [Source:SGD;Acc:S000001794]
K	YKR087C	OMA1	210	-187.9	4	Metalloendopeptidase of the mitochondrial inner membrane, involved in turnover of membrane-embedded proteins; member of a family of predicted membrane-bound metallopeptidases in prokaryotes and higher eukaryotes [Source:SGD;Acc:S000001795]
K	YKR088C	TVP38	88	-77.1	4	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; required for asymmetric localization of Kar9p during mitosis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000001796]
K	YKR089C	TGL4	585	-358.4	4	Multifunctional triacylglycerol lipase, steryl ester hydrolase, and Ca2+-independent phospholipase A2; catalyzes acyl-CoA dependent acylation of LPA to PA; required with Tgl3p for timely bud formation; phosphorylated and activated by Cdc28p [Source:SGD;Acc:S000001797]
K	YKR090W	PXL1	573	-275.6	4	LIM domain-containing protein that localizes to sites of polarized growth, required for selection and/or maintenance of polarized growth sites, may modulate signaling by the GTPases Cdc42p and Rho1p; has similarity to metazoan paxillin [Source:SGD;Acc:S000001798]
K	YKR091W	SRL3	151	-146	4	Cytoplasmic protein that, when overexpressed, suppresses the lethality of a rad53 null mutation; potential Cdc28p substrate [Source:SGD;Acc:S000001799]
K	YKR092C	SRP40	1443	-117.7	4	Nucleolar, serine-rich protein with a role in preribosome assembly or transport; may function as a chaperone of small nucleolar ribonucleoprotein particles (snoRNPs); immunologically and structurally to rat Nopp140 [Source:SGD;Acc:S000001800]
K	YKR093W	PTR2	828	-226.2	4	Integral membrane peptide transporter, mediates transport of di- and tri-peptides; conserved protein that contains 12 transmembrane domains; PTR2 expression is regulated by the N-end rule pathway via repression by Cup9p [Source:SGD;Acc:S000001801]
K	YKR094C	RPL40B	4750	-555.2	4	Fusion protein, identical to Rpl40Ap, that is cleaved to yield ubiquitin and a ribosomal protein of the large (60S) ribosomal subunit with similarity to rat L40; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes [Source:SGD;Acc:S000001802]
K	YKR095W	MLP1	1511	-1622	4	Myosin-like protein associated with the nuclear envelope, connects the nuclear pore complex with the nuclear interior; involved with Tel1p in telomere length control; involved with Pml1p and Pml39p in nuclear retention of unspliced mRNAs [Source:SGD;Acc:S000001803]
K	YKR095W-A	PCC1	443	-75.8	4	Component of the EKC/KEOPS protein complex with Kae1p, Gon7p, Bud32p, and Cgi121p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription [Source:SGD;Acc:S000028512]
K	YKR096W	ESL2	481	-290.9	4	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; predicted to contain a PINc domain [Source:SGD;Acc:S000001804]
K	YKR097W	PCK1	718	-2743.7	4	Phosphoenolpyruvate carboxykinase, key enzyme in gluconeogenesis, catalyzes early reaction in carbohydrate biosynthesis, glucose represses transcription and accelerates mRNA degradation, regulated by Mcm1p and Cat8p, located in the cytosol [Source:SGD;Acc:S000001805]
K	YKR098C	UBP11	68	-89	4	Ubiquitin-specific protease that cleaves ubiquitin from ubiquitinated proteins [Source:SGD;Acc:S000001806]
K	YKR099W	BAS1	217	-200	4	Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes [Source:SGD;Acc:S000001807]
K	YKR100C	SKG1	412	-149.9	4	Transmembrane protein with a role in cell wall polymer composition; localizes on the inner surface of the plasma membrane at the bud and in the daughter cell [Source:SGD;Acc:S000001808]
K	YKR101W	SIR1	84	-85.1	2	Protein involved in repression of transcription at the silent mating-type loci HML and HMR; recruitment to silent chromatin requires interactions with Orc1p and with Sir4p, through a common Sir1p domain; binds to centromeric chromatin [Source:SGD;Acc:S000001809]
K	YKR102W	FLO10	19	-31.3	3	Lectin-like protein with similarity to Flo1p, thought to be involved in flocculation [Source:SGD;Acc:S000001810]
K	YKR103W	NFT1	40	-18.1	2	Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds. [Source:SGD;Acc:S000001811]
K	YKR104W	YKR104W	73	-24.2	4	Putative transporter of the multidrug resistance-associated protein (MRP) subfamily; contains a stop codon in S288C; adjacent ORFs YKR103W and YKR104W are merged in different strain backgrounds [Source:SGD;Acc:S000001812]
K	YKR105C	VBA5	12	-23.7	2	Putative transporter of the Major Facilitator Superfamily (MFS); proposed role as a basic amino acid permease based on phylogeny [Source:SGD;Acc:S000001813]
K	YKR106W	GEX2	12	-3.6	2	Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway [Source:SGD;Acc:S000001814]
L	YLL001W	DNM1	1588	-963.7	4	Dynamin-related GTPase required for mitochondrial fission and morphology; assembles on the cytoplasmic face of mitochondrial tubules at sites at which division will occur; also participates in endocytosis and regulating peroxisome abundance [Source:SGD;Acc:S000003924]
L	YLL002W	RTT109	188	-74.7	4	Histone acetyltransferase critical for cell survival in the presence of DNA damage during S phase; acetylates H3-K56 and H3-K9; involved in non-homologous end joining and in regulation of Ty1 transposition; interacts physically with Vps75p [Source:SGD;Acc:S000003925]
L	YLL003W	SFI1	111	-362.7	4	Centrin (Cdc31p)-binding protein required for spindle pole body (SPB) duplication, localizes to the half-bridge of the SPB, required for progression through G(2)-M transition, has similarity to Xenopus laevis XCAP-C [Source:SGD;Acc:S000003926]
L	YLL004W	ORC3	185	-193.5	4	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing [Source:SGD;Acc:S000003927]
L	YLL005C	SPO75	16	-11.6	2	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis [Source:SGD;Acc:S000003928]
L	YLL006W	MMM1	162	-146.3	4	ER integral membrane protein, component of the ERMES complex that links the ER to mitochondria and may promote inter-organellar calcium and phospholipid exchange as well as coordinating mitochondrial DNA replication and growth [Source:SGD;Acc:S000003929]
L	YLL006W-A	YLL006W-A	1	-1.4	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028560]
L	YLL007C	YLL007C	144	-231.1	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL007C is not an essential gene [Source:SGD;Acc:S000003930]
L	YLL008W	DRS1	1627	-438.6	4	Nucleolar DEAD-box protein required for ribosome assembly and function, including synthesis of 60S ribosomal subunits; constituent of 66S pre-ribosomal particles [Source:SGD;Acc:S000003931]
L	YLL009C	COX17	295	-74.4	4	Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000003932]
L	YLL010C	PSR1	708	-123.8	4	Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p [Source:SGD;Acc:S000003933]
L	YLL011W	SOF1	977	-233.3	4	Essential protein required for biogenesis of 40S (small) ribosomal subunit; has similarity to the beta subunit of trimeric G-proteins and the splicing factor Prp4p [Source:SGD;Acc:S000003934]
L	YLL012W	YEH1	190	-113.7	4	Steryl ester hydrolase, one of three gene products (Yeh1p, Yeh2p, Tgl1p) responsible for steryl ester hydrolase activity and involved in sterol homeostasis; localized to lipid particle membranes [Source:SGD;Acc:S000003935]
L	YLL013C	PUF3	1119	-2456.1	4	Protein of the mitochondrial outer surface, links the Arp2/3 complex with the mitochore during anterograde mitochondrial movement; also binds to and promotes degradation of mRNAs for select nuclear-encoded mitochondrial proteins [Source:SGD;Acc:S000003936]
L	YLL014W	EMC6	92	-76	4	Member of a transmembrane complex required for efficient folding of proteins in the ER; null mutant displays induction of the unfolded protein response [Source:SGD;Acc:S000003937]
L	YLL015W	BPT1	685	-384.2	4	ABC type transmembrane transporter of MRP/CFTR family, found in vacuolar membrane, involved in the transport of unconjugated bilirubin and in heavy metal detoxification via glutathione conjugates, along with Ycf1p [Source:SGD;Acc:S000003938]
L	YLL018C	DPS1	3480	-1403.4	4	Aspartyl-tRNA synthetase, primarily cytoplasmic; homodimeric enzyme that catalyzes the specific aspartylation of tRNA(Asp); class II aminoacyl tRNA synthetase; binding to its own mRNA may confer autoregulation [Source:SGD;Acc:S000003941]
L	YLL018C-A	COX19	92	-102.4	4	Protein required for cytochrome c oxidase assembly, located in the cytosol and mitochondrial intermembrane space; putative copper metallochaperone that delivers copper to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000007245]
L	YLL019C	KNS1	215	-1463.4	4	Nonessential putative protein kinase of unknown cellular role; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues [Source:SGD;Acc:S000003942]
L	YLL019W-A	YLL019W-A	4	-8.9	2	Dubious open reading frame unlikely to encode a protein; completely overlaps the verified gene KNS1 [Source:SGD;Acc:S000028670]
L	YLL020C	YLL020C	5	-3.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene KNS1 [Source:SGD;Acc:S000003943]
L	YLL021W	SPA2	1697	-937.1	4	Component of the polarisome, which functions in actin cytoskeletal organization during polarized growth; acts as a scaffold for Mkk1p and Mpk1p cell wall integrity signaling components; potential Cdc28p substrate [Source:SGD;Acc:S000003944]
L	YLL022C	HIF1	363	-835.9	4	Non-essential component of the HAT-B histone acetyltransferase complex (Hat1p-Hat2p-Hif1p), localized to the nucleus; has a role in telomeric silencing [Source:SGD;Acc:S000003945]
L	YLL023C	POM33	634	-126.6	4	Transmembrane nucleoporin involved in nuclear pore complex (NPC) distribution, assembly or stabilization; highly conserved across species, orthologous to human TMEM33 and paralogous to Per33p [Source:SGD;Acc:S000003946]
L	YLL024C	SSA2	8279	-3755.5	4	ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% iden  with Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes [Source:SGD;Acc:S000003947]
L	YLL025W	PAU17	6	-2.5	2	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; YLL025W is not an essential gene [Source:SGD;Acc:S000003948]
L	YLL026W	HSP104	3730	-2424.7	4	Heat shock protein that cooperates with Ydj1p (Hsp40) and Ssa1p (Hsp70) to refold and reactivate previously denatured, aggregated proteins; responsive to stresses including: heat, ethanol, and sodium arsenite; involved in [PSI+] propagation [Source:SGD;Acc:S000003949]
L	YLL027W	ISA1	90	-100.5	4	Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa2p and possibly Iba57p; isa1 deletion causes loss of mitochondrial DNA and respiratory deficiency; depletion reduces growth on nonfermentable carbon s  ; functional ortholog of bacterial A-type ISC proteins [Source:SGD;Acc:S000003950]
L	YLL028W	TPO1	443	-155.5	4	Polyamine transporter that recognizes spermine, putrescine, and spermidine; catalyzes uptake of polyamines at alkaline pH and excretion at acidic pH; phosphorylation enhances activity and sorting to the plasma membrane [Source:SGD;Acc:S000003951]
L	YLL029W	FRA1	1143	-713.8	4	Protein involved in negative regulation of transcription of iron regulon; forms an iron independent complex with Fra2p, Grx3p, and Grx4p; cytosolic; mutant fails to repress transcription of iron regulon and is defective in spore formation [Source:SGD;Acc:S000003952]
L	YLL030C	RRT7	0	nf	1	Identified in a screen for mutants with increased levels of rDNA transcription; dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003953]
L	YLL031C	GPI13	265	-187.8	4	ER membrane localized phosphoryltransferase that adds phosphoethanolamine onto the third mannose residue of the glycosylphosphatidylinositol (GPI) anchor precursor; similar to human PIG-O protein [Source:SGD;Acc:S000003954]
L	YLL032C	YLL032C	446	-326.5	4	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene [Source:SGD;Acc:S000003955]
L	YLL033W	IRC19	28	-48.1	4	Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000003956]
L	YLL034C	RIX7	1163	-406.9	4	Putative ATPase of the AAA family, required for export of pre-ribosomal large subunits from the nucleus; distributed between the nucleolus, nucleoplasm, and nuclear periphery depending on growth conditions [Source:SGD;Acc:S000003957]
L	YLL035W	GRC3	149	-207.4	4	Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated [Source:SGD;Acc:S000003958]
L	YLL036C	PRP19	857	-402.6	4	Splicing factor associated with the spliceosome; contains a U-box, a motif found in a class of ubiquitin ligases, and a WD40 domain [Source:SGD;Acc:S000003959]
L	YLL037W	YLL037W	0	nf	1	Dubious open reading frame unlikely to encode a functional protein; overlaps 3' end of essential PRP19 gene encoding an RNA splicing factor [Source:SGD;Acc:S000003960]
L	YLL038C	ENT4	252	-142.2	4	Protein of unknown function, contains an N-terminal epsin-like domain; proposed to be involved in the trafficking of Arn1p in the absence of ferrichrome [Source:SGD;Acc:S000003961]
L	YLL039C	UBI4	4568	-573.8	4	Ubiquitin, becomes conjugated to proteins, marking them for selective degradation via the ubiquitin-26S proteasome system; essential for the cellular stress response; encoded as a polyubiquitin precursor comprised of 5 head-to-tail repeats [Source:SGD;Acc:S000003962]
L	YLL040C	VPS13	1600	-1982.7	4	Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; homologous to human COH1; involved in sporulation, vacuolar protein sorting and protein-Golgi retention [Source:SGD;Acc:S000003963]
L	YLL041C	SDH2	1079	-639.1	4	Iron-sulfur protein subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain [Source:SGD;Acc:S000003964]
L	YLL042C	ATG10	12	-27.1	2	Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy [Source:SGD;Acc:S000003965]
L	YLL043W	FPS1	430	-108	4	Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress [Source:SGD;Acc:S000003966]
L	YLL044W	YLL044W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLL044W and the overlapping gene RPL8B is reduced in the gcr1 null mutant [Source:SGD;Acc:S000003967]
L	YLL045C	RPL8B	4770	-1259.4	4	Ribosomal protein L4 of the large (60S) ribosomal subunit, nearly identical to Rpl8Ap and has similarity to rat L7a ribosomal protein; mutation results in decreased amounts of free 60S subunits [Source:SGD;Acc:S000003968]
L	YLL046C	RNP1	66	-16.3	2	Ribonucleoprotein that contains two RNA recognition motifs (RRM) [Source:SGD;Acc:S000003969]
L	YLL047W	YLL047W	1	0	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RNP1 [Source:SGD;Acc:S000003970]
L	YLL048C	YBT1	1942	-778.4	4	Transporter of the ATP-binding cassette (ABC) family involved in bile acid transport; similar to mammalian bile transporters [Source:SGD;Acc:S000003971]
L	YLL049W	LDB18	6	-6.4	2	Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24 [Source:SGD;Acc:S000003972]
L	YLL050C	COF1	2873	-450.9	4	Cofilin, promotes actin filament depolarization in a pH-dependent manner; binds both actin monomers and filaments and severs filaments; thought to be regulated by phosphorylation at SER4; ubiquitous and essential in eukaryotes [Source:SGD;Acc:S000003973]
L	YLL051C	FRE6	76	-102.1	4	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels [Source:SGD;Acc:S000003974]
L	YLL052C	AQY2	8	-25	3	Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains [Source:SGD;Acc:S000003975]
L	YLL053C	YLL053C	51	-15.7	3	Putative protein; in the Sigma 1278B strain background YLL053C is contiguous with AQY2 which encodes an aquaporin [Source:SGD;Acc:S000003976]
L	YLL054C	YLL054C	72	-82	4	Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene [Source:SGD;Acc:S000003977]
L	YLL055W	YCT1	30	-53.4	4	High-affinity cysteine-specific transporter with similarity to the Dal5p family of transporters; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YCT1 is not an essential gene [Source:SGD;Acc:S000003978]
L	YLL056C	YLL056C	71	-105.1	4	Putative protein of unknown function, transcription is activated by paralogous transcription factors Yrm1p and Yrr1p and genes involved in pleiotropic drug resistance (PDR); expression is induced in cells treated with the mycotoxin patulin [Source:SGD;Acc:S000003979]
L	YLL057C	JLP1	45	-227	4	Fe(II)-dependent sulfonate/alpha-ketoglutarate dioxygenase, involved in sulfonate catabolism for use as a sulfur source; contains sequence that resembles a J domain (typified by the E. coli DnaJ protein); induced by sulphur starvation [Source:SGD;Acc:S000003980]
L	YLL058W	YLL058W	170	-175.9	4	Putative protein of unknown function with similarity to Str2p, which is a cystathionine gamma-synthase important in sulfur metabolism; YLL058W is not an essential gene [Source:SGD;Acc:S000003981]
L	YLL059C	YLL059C	3	-2.5	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000003982]
L	YLL060C	GTT2	48	-51	4	Glutathione S-transferase capable of homodimerization; functional overlap with Gtt2p, Grx1p, and Grx2p [Source:SGD;Acc:S000003983]
L	YLL061W	MMP1	111	-53.4	4	High-affinity S-methylmethionine permease, required for utilization of S-methylmethionine as a sulfur source; has similarity to S-adenosylmethionine permease Sam3p [Source:SGD;Acc:S000003984]
L	YLL062C	MHT1	250	-105.4	4	S-methylmethionine-homocysteine methyltransferase, functions along with Sam4p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio [Source:SGD;Acc:S000003985]
L	YLL063C	AYT1	15	-26.9	2	Acetyltransferase; catalyzes trichothecene 3-O-acetylation, suggesting a possible role in trichothecene biosynthesis [Source:SGD;Acc:S000003986]
L	YLL064C	PAU18	0	nf	1	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau6p [Source:SGD;Acc:S000003987]
L	YLL065W	YLL065W	2	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps chromosome XII telomeric element core sequences [Source:SGD;Acc:S000003988]
L	YLL066C	YLL066C	350	-285.3	4	Putative protein of unknown function with similarity to helicases; YLL066C is not an essential gene [Source:SGD;Acc:S000003989]
L	YLL066W-A	YLL066W-A	43	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YLL066C [Source:SGD;Acc:S000028671]
L	YLL066W-B	YLL066W-B	0	nf	1	Putative protein of unknown function; overexpression causes a cell cycle delay or arrest [Source:SGD;Acc:S000028672]
L	YLL067C	YLL067C	344	-265	4	Putative protein of unknown function with similarity to helicases [Source:SGD;Acc:S000003990]
L	YLL067W-A	YLL067W-A	43	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps YLL067C [Source:SGD;Acc:S000028673]
L	YLR001C	YLR001C	212	-100.9	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; predicted to be palmitoylated [Source:SGD;Acc:S000003991]
L	YLR002C	NOC3	1186	-307.4	4	Protein that forms a nuclear complex with Noc2p that binds to 66S ribosomal precursors to mediate their intranuclear transport; also binds to chromatin to promote the association of DNA replication factors and replication initiation [Source:SGD;Acc:S000003992]
L	YLR003C	CMS1	882	-193.5	4	Subunit of U3-containing 90S preribosome processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; overexpression rescues supressor mutant of mcm10; null mutant is viable [Source:SGD;Acc:S000003993]
L	YLR004C	THI73	25	-88.9	4	Putative plasma membrane permease proposed to be involved in carboxylic acid uptake and repressed by thiamine; substrate of Dbf2p/Mob1p kinase; transcription is altered if mitochondrial dysfunction occurs [Source:SGD;Acc:S000003994]
L	YLR005W	SSL1	458	-242.5	4	Component of the core form of RNA polymerase transcription factor TFIIH, which has both protein kinase and DNA-dependent ATPase/helicase activities and is essential for transcription and nucleotide excision repair; interacts with Tfb4p [Source:SGD;Acc:S000003995]
L	YLR006C	SSK1	454	-1855.2	4	Cytoplasmic response regulator; part of a two-component signal transducer that mediates osmosensing via a phosphorelay mechanism; required for mitophagy; dephosphorylated form is degraded by the ubiquitin-proteasome system; potential Cdc28p substrate [Source:SGD;Acc:S000003996]
L	YLR007W	NSE1	123	-114.1	4	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair [Source:SGD;Acc:S000003997]
L	YLR008C	PAM18	740	-113.1	4	Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); essential J-protein cochaperone that stimulates Ssc1p ATPase activity to drive import; inhibited by Pam16p [Source:SGD;Acc:S000003998]
L	YLR009W	RLP24	863	-97.4	4	Essential protein with similarity to Rpl24Ap and Rpl24Bp, associated with pre-60S ribosomal subunits and required for ribosomal large subunit biogenesis [Source:SGD;Acc:S000003999]
L	YLR010C	TEN1	3	-1.6	1	Protein that regulates telomeric length; protects telomeric ends in a complex with Cdc13p and Stn1p [Source:SGD;Acc:S000004000]
L	YLR011W	LOT6	163	-70.3	4	FMN-dependent NAD(P)H:quinone reductase, may be involved in quinone detoxification; expression elevated at low temperature; sequesters the Cin5p transcription factor in the cytoplasm in complex with the proteasome under reducing conditions [Source:SGD;Acc:S000004001]
L	YLR012C	YLR012C	0	nf	1	Putative protein of unknown function; YLR012C is not an essential gene [Source:SGD;Acc:S000004002]
L	YLR013W	GAT3	3	-1.7	1	Protein containing GATA family zinc finger motifs [Source:SGD;Acc:S000004003]
L	YLR014C	PPR1	84	-67	4	Zinc finger transcription factor containing a Zn(2)-Cys(6) binuclear cluster domain, positively regulates transcription of genes involved in uracil biosynthesis; activity may be modulated by interaction with Tup1p [Source:SGD;Acc:S000004004]
L	YLR015W	BRE2	281	-153.6	4	Subunit of COMPASS (Set1C) complex, which methylates Lys4 of histone H3 and functions in silencing at telomeres; has a C-terminal Sdc1 Dpy-30 Interaction (SDI) domain that mediates binding to Sdc1p; similar to trithorax-group protein ASH2L [Source:SGD;Acc:S000004005]
L	YLR016C	PML1	46	-43.1	4	Subunit of the RES complex, which is required for nuclear retention of unspliced pre-mRNAs; acts in the same pathway as Pml39p and Mlp1p [Source:SGD;Acc:S000004006]
L	YLR017W	MEU1	1123	-231.4	4	Methylthioadenosine phosphorylase (MTAP), catalyzes the initial step in the methionine salvage pathway; affects polyamine biosynthesis through regulation of ornithine decarboxylase (Spe1p) activity; regulates ADH2 gene expression [Source:SGD;Acc:S000004007]
L	YLR018C	POM34	747	-224	4	Integral membrane protein of the nuclear pore; has an important role in maintaining the architecture of the pore complex [Source:SGD;Acc:S000004008]
L	YLR019W	PSR2	346	-1011.3	4	Functionally redundant Psr1p homolog, a plasma membrane phosphatase involved in the general stress response; required with Psr1p and Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p [Source:SGD;Acc:S000004009]
L	YLR020C	YEH2	385	-181.9	4	Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism [Source:SGD;Acc:S000004010]
L	YLR021W	IRC25	169	-62.7	4	Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions [Source:SGD;Acc:S000004011]
L	YLR022C	SDO1	708	-256.9	4	Essential protein involved in 60S ribosome maturation; ortholog of the human protein (SBDS) responsible for autosomal recessive Shwachman-Bodian-Diamond Syndrome; highly conserved across archae and eukaryotes [Source:SGD;Acc:S000004012]
L	YLR023C	IZH3	35	-23.2	4	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by zinc deficiency; deletion reduces sensitivity to elevated zinc and shortens lag phase, overexpression reduces Zap1p activity [Source:SGD;Acc:S000004013]
L	YLR024C	UBR2	265	-215.4	4	Cytoplasmic ubiquitin-protein ligase (E3); required for ubiquitylation of Rpn4p; mediates formation of a Mub1p-Ubr2p-Rad6p complex [Source:SGD;Acc:S000004014]
L	YLR025W	SNF7	1666	-272.2	4	One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes [Source:SGD;Acc:S000004015]
L	YLR026C	SED5	626	-233.5	4	cis-Golgi t-SNARE syntaxin required for vesicular transport between the ER and the Golgi complex, binds at least 9 SNARE proteins [Source:SGD;Acc:S000004016]
L	YLR027C	AAT2	2791	-1004.2	4	Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells [Source:SGD;Acc:S000004017]
L	YLR028C	ADE16	2689	-897	4	Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade17p; ade16 ade17 mutants require adenine and histidine [Source:SGD;Acc:S000004018]
L	YLR029C	RPL15A	3986	-536	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Bp and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA [Source:SGD;Acc:S000004019]
L	YLR030W	YLR030W	4	-2.1	2	Putative protein of unknown function [Source:SGD;Acc:S000004020]
L	YLR031W	YLR031W	6	-2.7	2	Putative protein of unknown function [Source:SGD;Acc:S000004021]
L	YLR032W	RAD5	358	-273.3	4	DNA helicase proposed to promote replication fork regression during postreplication repair by template switching; RING finger containing ubiquitin ligase; stimulates the synthesis of free and PCNA-bound polyubiquitin chains by Ubc13p-Mms2p [Source:SGD;Acc:S000004022]
L	YLR033W	RSC58	882	-377.5	4	Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance [Source:SGD;Acc:S000004023]
L	YLR034C	SMF3	452	-116.8	4	Putative divalent metal ion transporter involved in iron homeostasis; transcriptionally regulated by metal ions; member of the Nramp family of metal transport proteins [Source:SGD;Acc:S000004024]
L	YLR035C	MLH2	50	-36.3	2	Protein involved in the mismatch repair of certain frameshift intermediates and involved in meiotic recombination; forms a complex with Mlh1p [Source:SGD;Acc:S000004025]
L	YLR035C-A	YLR035C-A	2749	-905	4	Retrotransposon TYA Gag and TYB Pol genes; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); YLR035C-A is part of a mutant retrotransposon [Source:SGD;Acc:S000007225]
L	YLR036C	YLR036C	62	-21.3	4	Putative protein of unknown function predicted to have transmembrane domains; interacts with HSP90 by yeast two-hybrid analysis; YLR036C is not an essential protein [Source:SGD;Acc:S000004026]
L	YLR037C	PAU23	4	-9.3	2	Cell wall mannoprotein with similarity to Tir1p, Tir2p, Tir3p, and Tir4p; member of the seripauperin multigene family encoded mainly in subtelomeric regions; expressed under anaerobic conditions, completely repressed during aerobic growth [Source:SGD;Acc:S000004027]
L	YLR038C	COX12	1041	-332.4	4	Subunit VIb of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated [Source:SGD;Acc:S000004028]
L	YLR039C	RIC1	228	-299.3	4	Protein involved in retrograde transport to the cis-Golgi network; forms heterodimer with Rgp1p that acts as a GTP exchange factor for Ypt6p; involved in transcription of rRNA and ribosomal protein genes [Source:SGD;Acc:S000004029]
L	YLR040C	AFB1	21	-12.9	4	Putative protein of unknown function; localizes to the cell wall; predicted to be a GPI-attached protein; upregulated by Mcm1p-Alpha1p transcription factor; partially overlaps the dubious ORF YLR041W; YLR040C is not essential [Source:SGD;Acc:S000004030]
L	YLR041W	YLR041W	3	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YLR040C [Source:SGD;Acc:S000004031]
L	YLR042C	YLR042C	1	0	1	Protein of unknown function; localizes to the cytoplasm; YLL042C is not an essential gene [Source:SGD;Acc:S000004032]
L	YLR043C	TRX1	2740	-271.6	4	Cytoplasmic thioredoxin isoenzyme of the thioredoxin system which protects cells against oxidative and reductive stress, forms LMA1 complex with Pbi2p, acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance [Source:SGD;Acc:S000004033]
L	YLR044C	PDC1	6888	-4196.8	4	Major of three pyruvate decarboxylase isozymes, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde; subject to glucose-, ethanol-, and autoregulation; involved in amino acid catabolism [Source:SGD;Acc:S000004034]
L	YLR045C	STU2	798	-472.2	4	Microtubule-associated protein (MAP) of the XMAP215/Dis1 family; regulates microtubule dynamics during spindle orientation and metaphase chromosome alignment; interacts with spindle pole body component Spc72p [Source:SGD;Acc:S000004035]
L	YLR046C	YLR046C	5	-3.8	2	Putative membrane protein; member of the fungal lipid-translocating exporter (LTE) family of proteins; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance [Source:SGD;Acc:S000004036]
L	YLR047C	FRE8	48	-96.9	4	Protein with sequence similarity to iron/copper reductases, involved in iron homeostasis; deletion mutant has iron deficiency/accumulation growth defects; expression increased in the absence of copper-responsive transcription factor Mac1p [Source:SGD;Acc:S000004037]
L	YLR048W	RPS0B	4307	-964.8	4	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps0Ap; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal [Source:SGD;Acc:S000004038]
L	YLR049C	YLR049C	70	-25	4	Putative protein of unknown function [Source:SGD;Acc:S000004039]
L	YLR050C	YLR050C	116	-52	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YLR050C is not an essential gene [Source:SGD;Acc:S000004040]
L	YLR051C	FCF2	466	-185.3	4	Essential nucleolar protein involved in the early steps of 35S rRNA processing; interacts with Faf1p; member of a transcriptionally co-regulated set of genes called the RRB regulon [Source:SGD;Acc:S000004041]
L	YLR052W	IES3	359	-1384.5	4	Subunit of the INO80 chromatin remodeling complex [Source:SGD;Acc:S000004042]
L	YLR053C	YLR053C	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000004043]
L	YLR054C	OSW2	68	-7.8	2	Protein of unknown function proposed to be involved in the assembly of the spore wall [Source:SGD;Acc:S000004044]
L	YLR055C	SPT8	890	-1089.3	4	Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters [Source:SGD;Acc:S000004045]
L	YLR056W	ERG3	1142	-167.9	4	C-5 sterol desaturase, catalyzes the introduction of a C-5(6) double bond into episterol, a precursor in ergosterol biosynthesis; mutants are viable, but cannot grow on non-fermentable carbon sources [Source:SGD;Acc:S000004046]
L	YLR057W	MNL2	281	-250.7	4	Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose   es; non-essential gene [Source:SGD;Acc:S000004047]
L	YLR058C	SHM2	3754	-2254.7	4	Cytosolic serine hydroxymethyltransferase, converts serine to glycine plus 5,10 methylenetetrahydrofolate; major isoform involved in generating precursors for purine, pyrimidine, amino acid, and lipid biosynthesis [Source:SGD;Acc:S000004048]
L	YLR059C	REX2	617	-179.6	4	3'-5' RNA exonuclease; involved in 3'-end processing of U4 and U5 snRNAs, 5S and 5.8S rRNAs, and RNase P and RNase MRP RNA; localized to mitochondria and null suppresses escape of mtDNA to nucleus in yme1 yme2 mutants; RNase D exonuclease [Source:SGD;Acc:S000004049]
L	YLR060W	FRS1	2887	-1021.4	4	Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control [Source:SGD;Acc:S000004050]
L	YLR061W	RPL22A	2980	-412.9	4	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl22Bp and to rat L22 ribosomal protein [Source:SGD;Acc:S000004051]
L	YLR062C	BUD28	3	-1.4	1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene RPL22A; diploid mutant displays a weak budding pattern phenotype in a systematic assay [Source:SGD;Acc:S000004052]
L	YLR063W	BMT6	222	-127.4	4	Putative S-adenosylmethionine-dependent methyltransferase; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR063W is not an essential gene [Source:SGD;Acc:S000004053]
L	YLR064W	PER33	142	-48.3	4	Protein that localizes to the endoplasmic reticulum with some nuclear pore complex association; deletion extends chronological lifespan; highly conserved across species, orthologous to human TMEM33 and paralogous to Pom33p [Source:SGD;Acc:S000004054]
L	YLR065C	ENV10	172	-57	4	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; YLR065C is not an essential gene [Source:SGD;Acc:S000004055]
L	YLR066W	SPC3	525	-111.5	4	Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC22/23 [Source:SGD;Acc:S000004056]
L	YLR067C	PET309	93	-267.3	4	Specific translational activator for the COX1 mRNA, also influences stability of intron-containing COX1 primary transcripts; localizes to the mitochondrial inner membrane; contains seven pentatricopeptide repeats (PPRs) [Source:SGD;Acc:S000004057]
L	YLR068W	FYV7	153	-49	4	Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin [Source:SGD;Acc:S000004058]
L	YLR069C	MEF1	775	-364.8	4	Mitochondrial elongation factor involved in translational elongation [Source:SGD;Acc:S000004059]
L	YLR070C	XYL2	67	-133.2	4	Xylitol dehydrogenase, converts xylitol to D-xylulose; expression induced by xylose, even though this pentose sugar is not well utilized by S. cerevisiae; null mutant has cell wall defect [Source:SGD;Acc:S000004060]
L	YLR071C	RGR1	676	-350.1	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for glucose repression, HO repression, RME1 repression and sporulation [Source:SGD;Acc:S000004061]
L	YLR072W	YLR072W	420	-308.4	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YLR072W is not an esssential gene [Source:SGD;Acc:S000004062]
L	YLR073C	RFU1	15	-19	2	Protein that inhibits Doa4p deubiquitinating activity; contributes to ubiquitin homeostasis by regulating the conversion of free ubiquitin chains to ubiquitin monomers by Doa4p; GFP-fusion protein localizes to endosomes [Source:SGD;Acc:S000004063]
L	YLR074C	BUD20	680	-112.3	4	Protein involved in bud-site selection; diploid mutants display a random budding pattern instead of the wild-type bipolar pattern [Source:SGD;Acc:S000004064]
L	YLR075W	RPL10	4623	-979.5	4	Protein component of the large (60S) ribosomal subunit, responsible for joining the 40S and 60S subunits; regulates translation initiation; has similarity to rat L10 ribosomal protein and to members of the QM gene family [Source:SGD;Acc:S000004065]
L	YLR076C	YLR076C	6	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPL10 which encodes the ribosomal protein L10 [Source:SGD;Acc:S000004066]
L	YLR077W	FMP25	431	-285	4	Mitochondrial inner membrane protein required for an early step in assembly of respiratory complex III (cytochrome bc1 complex); mRNA is targeted to mitochondria [Source:SGD;Acc:S000004067]
L	YLR078C	BOS1	527	-174.3	4	v-SNARE (vesicle specific SNAP receptor), localized to the endoplasmic reticulum membrane and necessary for vesicular transport from the ER to the Golgi [Source:SGD;Acc:S000004068]
L	YLR079W	SIC1	474	-346	4	Inhibitor of Cdc28-Clb kinase complexes that controls G1/S phase transition, preventing premature S phase and ensuring genomic integrity; phosphorylation targets Sic1p for SCF(CDC4)-dependent turnover; functional homolog of mammalian Kip1 [Source:SGD;Acc:S000004069]
L	YLR080W	EMP46	244	-302.7	4	Integral membrane component of endoplasmic reticulum-derived COPII-coated vesicles, which function in ER to Golgi transport [Source:SGD;Acc:S000004070]
L	YLR081W	GAL2	321	-410.2	4	Galactose permease, required for utilization of galactose; also able to transport glucose [Source:SGD;Acc:S000004071]
L	YLR082C	SRL2	178	-206.1	4	Protein of unknown function; overexpression suppresses the lethality caused by a rad53 null mutation [Source:SGD;Acc:S000004072]
L	YLR083C	EMP70	927	-211	4	Protein with a role in cellular adhesion, filamentous growth, and endosome-to-vacuole sorting; similar to Tmn2p and Tmn3p; member of Transmembrane Nine family of proteins with 9 transmembrane segments [Source:SGD;Acc:S000004073]
L	YLR084C	RAX2	206	-172	4	N-glycosylated protein involved in the maintenance of bud site selection during bipolar budding; localization requires Rax1p; RAX2 mRNA stability is regulated by Mpt5p [Source:SGD;Acc:S000004074]
L	YLR085C	ARP6	140	-1200	4	Actin-related protein that binds nucleosomes; a component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A [Source:SGD;Acc:S000004075]
L	YLR086W	SMC4	420	-478.6	4	Subunit of the condensin complex; reorganizes chromosomes during cell division; forms a complex with Smc2p that has ATP-hydrolyzing and DNA-binding activity; required for tRNA gene clustering at the nucleolus; potential Cdc28p substrate [Source:SGD;Acc:S000004076]
L	YLR087C	CSF1	128	-319.2	4	Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004077]
L	YLR088W	GAA1	431	-240.1	4	Subunit of the GPI (glycosylphosphatidylinositol):protein transamidase complex, removes the GPI-anchoring signal and attaches GPI to proteins in the ER [Source:SGD;Acc:S000004078]
L	YLR089C	ALT1	1173	-668.5	4	Alanine transaminase (glutamic pyruvic transaminase); involved in alanine biosynthetic and catabolic processes; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004079]
L	YLR090W	XDJ1	292	-198.5	4	Putative chaperone, homolog of E. coli DnaJ, closely related to Ydj1p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004080]
L	YLR091W	GEP5	42	-74.6	4	Protein of unknown function, required for mitochondrial genome maintenance; detected in highly purified mitochondria in high-throughput studies; null mutant has decreased levels of cardiolipin and phosphatidylethanolamine [Source:SGD;Acc:S000004081]
L	YLR092W	SUL2	36	-86.3	4	High affinity sulfate permease; sulfate uptake is mediated by specific sulfate transporters Sul1p and Sul2p, which control the concentration of endogenous activated sulfate intermediates [Source:SGD;Acc:S000004082]
L	YLR093C	NYV1	589	-192.3	4	v-SNARE component of the vacuolar SNARE complex involved in vesicle fusion; inhibits ATP-dependent Ca(2+) transport activity of Pmc1p in the vacuolar membrane [Source:SGD;Acc:S000004083]
L	YLR094C	GIS3	55	-60.9	4	Protein of unknown function [Source:SGD;Acc:S000004084]
L	YLR095C	IOC2	631	-344.7	4	Member of a complex (Isw1b) with Isw1p and Ioc4p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PHD finger motif [Source:SGD;Acc:S000004085]
L	YLR096W	KIN2	1035	-2757.1	4	Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin1p [Source:SGD;Acc:S000004086]
L	YLR097C	HRT3	89	-156.3	4	Putative SCF-ubiquitin ligase F-box protein, based on both genetic and physical interactions and sequence similarity; identified in association with Cdc53p, Skp1p and Ubi4 in large and small-scale studies [Source:SGD;Acc:S000004087]
L	YLR098C	CHA4	236	-139.1	4	DNA binding transcriptional activator, mediates serine/threonine activation of the catabolic L-serine (L-threonine) deaminase (CHA1); Zinc-finger protein with Zn[2]-Cys[6] fungal-type binuclear cluster domain [Source:SGD;Acc:S000004088]
L	YLR099C	ICT1	52	-47.7	4	Lysophosphatidic acid acyltransferase, responsible for enhanced phospholipid synthesis during organic solvent stress; null displays increased sensitivity to Calcofluor white; highly expressed during organic solvent stress [Source:SGD;Acc:S000004089]
L	YLR099W-A	MIM2	137	-20.9	4	Putative protein of unknown function [Source:SGD;Acc:S000007618]
L	YLR100W	ERG27	1349	-471.5	4	3-keto sterol reductase, catalyzes the last of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants are sterol auxotrophs [Source:SGD;Acc:S000004090]
L	YLR101C	YLR101C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF ERG27/YLR100W [Source:SGD;Acc:S000004091]
L	YLR102C	APC9	67	-106.7	4	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition [Source:SGD;Acc:S000004092]
L	YLR103C	CDC45	164	-207.9	4	DNA replication initiation factor; recruited to MCM pre-RC complexes at replication origins; promotes release of MCM from Mcm10p, recruits elongation machinery; mutants in human homolog may cause velocardiofacial and DiGeorge syndromes [Source:SGD;Acc:S000004093]
L	YLR104W	LCL2	175	-62.9	4	Putative protein of unknown function; mutant is deficient in amounts of cell wall mannosylphosphate and has long chronological lifespan; genetic interactions suggest a role in ER-associated protein degradation (ERAD) [Source:SGD;Acc:S000004094]
L	YLR105C	SEN2	67	-116.1	4	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p; Sen2p contains the active site for tRNA 5' splice site cleavage and has similarity to Sen34p and to Archaeal tRNA splicing endonuclease [Source:SGD;Acc:S000004095]
L	YLR106C	MDN1	2273	-3339.8	4	Huge dynein-related AAA-type ATPase (midasin), forms extended pre-60S particle with the Rix1 complex (Rix1p-Ipi1p-Ipi3p); acts in removal of ribosomal biogenesis factors at successive steps of pre-60S assembly and export from nucleus [Source:SGD;Acc:S000004096]
L	YLR107W	REX3	92	-166.5	4	RNA exonuclease; required for maturation of the RNA component of RNase MRP; functions redundantly with Rnh70p and Rex2p in processing of U5 snRNA and RNase P RNA; member of RNase D family of exonucleases [Source:SGD;Acc:S000004097]
L	YLR108C	YLR108C	147	-109.5	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YLR108C is not an esssential gene [Source:SGD;Acc:S000004098]
L	YLR109W	AHP1	4398	-1089	4	Thiol-specific peroxiredoxin, reduces hydroperoxides to protect against oxidative damage; function in vivo requires covalent conjugation to Urm1p [Source:SGD;Acc:S000004099]
L	YLR110C	CCW12	215	-67.6	4	Cell wall mannoprotein with a role in maintenance of newly synthesized areas of cell wall; localizes to periphery of small buds, septum region of larger buds, and shmoo tip [Source:SGD;Acc:S000004100]
L	YLR111W	YLR111W	4	0	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004101]
L	YLR112W	YLR112W	4	-3.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004102]
L	YLR113W	HOG1	1443	-704.1	4	Mitogen-activated protein kinase involved in osmoregulation; acts via three independent osmosensors; mitophagy-specific regulator; mediates the recruitment and activation of RNA Pol II at Hot1p-dependent promoters; localization regulated by Ptp2p an  p [Source:SGD;Acc:S000004103]
L	YLR114C	AVL9	777	-437.4	4	Conserved protein involved in exocytic transport from the Golgi; mutation is synthetically lethal with apl2 vps1 double mutation; member of a protein superfamily with orthologs in diverse organisms [Source:SGD;Acc:S000004104]
L	YLR115W	CFT2	372	-374.2	4	Subunit of the mRNA cleavage and polyadenlylation factor (CPF); required for pre-mRNA cleavage, polyadenylation and poly(A) site recognition, 43% similarity with the mammalian CPSF-100 protein. [Source:SGD;Acc:S000004105]
L	YLR116W	MSL5	498	-180.6	4	Component of the commitment complex, which defines the first step in the splicing pathway; essential protein that interacts with Mud2p and Prp40p, forming a bridge between the intron ends; also involved in nuclear retention of pre-mRNA [Source:SGD;Acc:S000004106]
L	YLR117C	CLF1	164	-340	4	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins [Source:SGD;Acc:S000004107]
L	YLR118C	YLR118C	702	-147	4	Acyl-protein thioesterase responsible for depalmitoylation of Gpa1p; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000004108]
L	YLR119W	SRN2	216	-127.4	4	Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; suppressor of rna1-1 mutation; may be involved in RNA export from nucleus [Source:SGD;Acc:S000004109]
L	YLR120C	YPS1	316	-109.8	4	Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor [Source:SGD;Acc:S000004110]
L	YLR120W-A	YLR120W-A	3	-4.1	2	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified ORF YLR121C [Source:SGD;Acc:S000028674]
L	YLR121C	YPS3	106	-80.2	4	Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor [Source:SGD;Acc:S000004111]
L	YLR122C	YLR122C	2	-3.5	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR123C [Source:SGD;Acc:S000004112]
L	YLR123C	YLR123C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR122C; contains characteristic aminoacyl-tRNA motif [Source:SGD;Acc:S000004113]
L	YLR124W	YLR124W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004114]
L	YLR125W	YLR125W	17	-19.2	2	Putative protein of unknown function; mutant has decreased Ty3 transposition; YLR125W is not an essential gene [Source:SGD;Acc:S000004115]
L	YLR126C	YLR126C	399	-109.9	4	Putative protein of unknown function with similarity to glutamine amidotransferase proteins; has Aft1p-binding motif in the promoter; may be involved in copper and iron homeostasis; YLR126C is not an essential protein [Source:SGD;Acc:S000004116]
L	YLR127C	APC2	96	-401.5	4	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the catalytic core of  PC/C; has similarity to cullin Cdc53p [Source:SGD;Acc:S000004117]
L	YLR128W	DCN1	119	-120.4	4	Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation [Source:SGD;Acc:S000004118]
L	YLR129W	DIP2	1127	-516.1	4	Nucleolar protein, specifically associated with the U3 snoRNA, part of the large ribonucleoprotein complex known as the small subunit (SSU) processome, required for 18S rRNA biogenesis, part of the active pre-rRNA processing complex [Source:SGD;Acc:S000004119]
L	YLR130C	ZRT2	186	-66.9	4	Low-affinity zinc transporter of the plasma membrane; transcription is induced under low-zinc conditions by the Zap1p transcription factor [Source:SGD;Acc:S000004120]
L	YLR131C	ACE2	470	-181.1	4	Transcription factor required for septum destruction after cytokinesis; phosphorylation by Cbk1p blocks nuclear exit of Ace2p during the M-to-G1 transition, causing its specific localization to daughter cell nuclei, and also increases Ace2p activity  phorylation by Cdc28p and Pho85p prevents nuclear import during cell cycle phases other than cytokinesis; part of the RAM network that regulates cellular polarity and morphogenesis [Source:SGD;Acc:S000004121]
L	YLR132C	USB1	85	-96.3	4	Essential protein that localizes to the nucleus and mitochondria; overexpression suppresses the respiratory defects of oxa1 and mtf2 mutants [Source:SGD;Acc:S000004122]
L	YLR133W	CKI1	989	-964	4	Choline kinase, catalyzing the first step in phosphatidylcholine synthesis via the CDP-choline (Kennedy pathway); exhibits some ethanolamine kinase activity contributing to phosphatidylethanolamine synthesis via the CDP-ethanolamine pathway [Source:SGD;Acc:S000004123]
L	YLR134W	PDC5	4542	-1347.1	4	Minor isoform of pyruvate decarboxylase, key enzyme in alcoholic fermentation, decarboxylates pyruvate to acetaldehyde, regulation is glucose- and ethanol-dependent, repressed by thiamine, involved in amino acid catabolism [Source:SGD;Acc:S000004124]
L	YLR135W	SLX4	101	-111.2	4	Endonuclease involved in processing DNA during recombination and repair; cleaves branched structures in a complex with Slx1p; involved in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing [Source:SGD;Acc:S000004125]
L	YLR136C	TIS11	15	-24.3	4	mRNA-binding protein expressed during iron starvation; binds to a sequence element in the 3'-untranslated regions of specific mRNAs to mediate their degradation; involved in iron homeostasis [Source:SGD;Acc:S000004126]
L	YLR137W	RKM5	84	-128.3	4	Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species [Source:SGD;Acc:S000004127]
L	YLR138W	NHA1	403	-286.4	4	Na+/H+ antiporter involved in sodium and potassium efflux through the plasma membrane; required for alkali cation tolerance at acidic pH [Source:SGD;Acc:S000004128]
L	YLR139C	SLS1	225	-211.2	4	Mitochondrial membrane protein that coordinates expression of mitochondrially-encoded genes; may facilitate delivery of mRNA to membrane-bound translation machinery [Source:SGD;Acc:S000004129]
L	YLR140W	YLR140W	1	-1.8	1	Dubious open reading frame unlikely to encode a functional protein; overlaps essential RRN5 gene which encodes a member of the UAF transcription factor involved in transcription of rDNA by RNA polymerase I [Source:SGD;Acc:S000004130]
L	YLR141W	RRN5	51	-126.7	4	Protein involved in transcription of rDNA by RNA polymerase I; transcription factor, member of UAF (upstream activation factor) family along with Rrn9p and Rrn10p [Source:SGD;Acc:S000004131]
L	YLR142W	PUT1	174	-351.4	4	Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source [Source:SGD;Acc:S000004132]
L	YLR143W	DPH6	658	-198.8	4	Putative protein of unknown function; green fluorescent protein (GFP)-tagged protein localizes to the cytoplasm; YLR143W is not an essential gene [Source:SGD;Acc:S000004133]
L	YLR144C	ACF2	342	-382.1	4	Intracellular beta-1,3-endoglucanase, expression is induced during sporulation; may have a role in cortical actin cytoskeleton assembly [Source:SGD;Acc:S000004134]
L	YLR145W	RMP1	31	-44.3	4	Subunit of RNase MRP, which processes pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; unlike most subunits, not shared between RNase MRP and nuclear RNase P [Source:SGD;Acc:S000004135]
L	YLR146C	SPE4	299	-145.7	4	Spermine synthase, required for the biosynthesis of spermine and also involved in biosynthesis of pantothenic acid [Source:SGD;Acc:S000004136]
L	YLR146W-A	YLR146W-A	30	-31.1	4	Putative protein of unknown function [Source:SGD;Acc:S000113566]
L	YLR147C	SMD3	322	-112.4	4	Core Sm protein Sm D3; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D3 [Source:SGD;Acc:S000004137]
L	YLR148W	PEP3	512	-376.1	4	Component of CORVET tethering complex; vacuolar peripheral membrane protein that promotes vesicular docking/fusion reactions in conjunction with SNARE proteins, required for vacuolar biogenesis [Source:SGD;Acc:S000004138]
L	YLR149C	YLR149C	211	-91.6	4	Putative protein of unknown function; overexpression causes a cell cycle delay or arrest; null mutation results in a decrease in plasma membrane electron transport; YLR149C is not an essential gene [Source:SGD;Acc:S000004139]
L	YLR149C-A	YLR149C-A	2	0	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007619]
L	YLR150W	STM1	4378	-1542.8	4	Protein required for optimal translation under nutrient stress; perturbs association of Yef3p with ribosomes; involved in TOR signaling; binds G4 quadruplex and purine motif triplex nucleic acid; helps maintain telomere structure [Source:SGD;Acc:S000004140]
L	YLR151C	PCD1	108	-153.4	4	Peroxisomal nudix pyrophosphatase with specificity for coenzyme A and CoA derivatives, may function to remove potentially toxic oxidized CoA disulfide from peroxisomes to maintain the capacity for beta-oxidation of fatty acids [Source:SGD;Acc:S000004141]
L	YLR152C	YLR152C	49	-40	4	Putative protein of unknown function; YLR152C is not an essential gene [Source:SGD;Acc:S000004142]
L	YLR153C	ACS2	3407	-1850.6	4	Acetyl-coA synthetase isoform which, along with Acs1p, is the nuclear source of acetyl-coA for histone acetylation; mutants affect global transcription; required for growth on glucose; expressed under anaerobic conditions [Source:SGD;Acc:S000004143]
L	YLR154C	RNH203	89	-50.2	4	Ribonuclease H2 subunit, required for RNase H2 activity; related to human AGS3 that causes Aicardi-Goutieres syndrome [Source:SGD;Acc:S000004144]
L	YLR154C-G	YLR154C-G	1	-1.7	1	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF is contained within RDN25-2 and RDN37-2 [Source:SGD;Acc:S000028561]
L	YLR154C-H	YLR154C-H	2	-2.4	2	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-2 [Source:SGD;Acc:S000028562]
L	YLR154W-A	YLR154W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand [Source:SGD;Acc:S000028675]
L	YLR154W-B	YLR154W-B	2	-3.2	2	Dubious open reading frame unlikely to encode a protein; encoded within the the 25S rRNA gene on the opposite strand [Source:SGD;Acc:S000028563]
L	YLR154W-C	TAR1	6	-6.4	2	Mitochondrial protein potentially involved in regulation of respiratory metabolism; interacts genetically with RPO41 and physically with Coq5p; encoded within the 25S rRNA gene on the opposite strand [Source:SGD;Acc:S000028422]
L	YLR154W-E	YLR154W-E	9	-1.7	1	Dubious open reading frame unlikely to encode a protein; encoded within the the 35S rRNA gene on the opposite strand [Source:SGD;Acc:S000028676]
L	YLR154W-F	YLR154W-F	4	-2.6	2	Dubious open reading frame unlikely to encode a protein; encoded within the the 35S rRNA gene on the opposite strand [Source:SGD;Acc:S000028843]
L	YLR155C	ASP3-1	107	-177.4	4	Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3 [Source:SGD;Acc:S000004145]
L	YLR156C-A	YLR156C-A	2	-2.4	2	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-3 [Source:SGD;Acc:S000028564]
L	YLR156W	YLR156W	1	-1.1	1	Putative protein of unknown function; exhibits a two-hybrid interaction with Jsn1p in a large-scale analysis [Source:SGD;Acc:S000004146]
L	YLR157C	ASP3-2	107	-177.4	4	Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3 [Source:SGD;Acc:S000004147]
L	YLR157C-A	YLR157C-A	4728	-1742.3	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007373]
L	YLR157C-B	YLR157C-B	5026	-2554	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007374]
L	YLR157C-C	YLR157C-C	2	-2.4	2	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-4 [Source:SGD;Acc:S000028565]
L	YLR157W-D	YLR157W-D	1	-1.6	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028677]
L	YLR157W-E	YLR157W-E	2	-2.3	2	Putative protein of unknown function identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; partially overlaps a Ty1 element [Source:SGD;Acc:S000028678]
L	YLR158C	ASP3-3	107	-177.4	4	Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3 [Source:SGD;Acc:S000004148]
L	YLR159C-A	YLR159C-A	2	-2.4	2	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; this ORF partially overlaps RND5-5 [Source:SGD;Acc:S000028566]
L	YLR159W	YLR159W	1	-1.1	1	Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12 [Source:SGD;Acc:S000004149]
L	YLR160C	ASP3-4	107	-177.4	4	Cell-wall L-asparaginase II involved in asparagine catabolism; expression induced during nitrogen starvation; ORF contains a short non-coding RNA that enhances expression of full-length gene; reference strain S288C has four copies of ASP3 [Source:SGD;Acc:S000004150]
L	YLR161W	YLR161W	1	-1.1	1	Putative protein of unknown function; YLR156W, YLR159W, and YLR161W are three identical open reading frames encoded near the ribosomal DNA region of chromosome 12 [Source:SGD;Acc:S000004151]
L	YLR162W	YLR162W	18	-2.4	2	Putative protein of unknown function; overexpression confers resistance to the antimicrobial peptide MiAMP1 and causes growth arrest, apoptosis, and increased sensitivity to cobalt chloride [Source:SGD;Acc:S000004152]
L	YLR162W-A	RRT15	3	-1.9	1	Putative protein of unknown function identified by fungal homology comparisons and RT-PCR; identified in a screen for mutants with decreased levels of rDNA transcription [Source:SGD;Acc:S000028567]
L	YLR163C	MAS1	862	-253.8	4	Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins [Source:SGD;Acc:S000004153]
L	YLR163W-A	YLR163W-A	3	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data [Source:SGD;Acc:S000028844]
L	YLR164W	SHH4	53	-58.1	4	Mitochondrial inner membrane protein of unknown function; similar to Tim18p and Sdh4p; expression induced by nitrogen limitation in a GLN3, GAT1-dependent manner [Source:SGD;Acc:S000004154]
L	YLR165C	PUS5	15	-102.7	3	Pseudouridine synthase, catalyzes only the formation of pseudouridine (Psi)-2819 in mitochondrial 21S rRNA; not essential for viability [Source:SGD;Acc:S000004155]
L	YLR166C	SEC10	555	-406.2	4	Essential 100kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis [Source:SGD;Acc:S000004156]
L	YLR167W	RPS31	5105	-5999	4	Fusion protein that is cleaved to yield a ribosomal protein of the small (40S) subunit and ubiquitin; ubiquitin may facilitate assembly of the ribosomal protein into ribosomes; interacts genetically with translation factor eIF2B [Source:SGD;Acc:S000004157]
L	YLR168C	UPS2	38	-19.1	3	Mitochondrial intermembrane space protein involved in regulation of mitochondrial cardiolipin and phosphatidylethanolamine levels; null has defects in mitochondrial morphology; similar to Ups1p, Ups3p and to human PRELI [Source:SGD;Acc:S000004158]
L	YLR169W	YLR169W	1	-1.1	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004159]
L	YLR170C	APS1	124	-105.7	4	Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex [Source:SGD;Acc:S000004160]
L	YLR171W	YLR171W	8	-2.4	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004161]
L	YLR172C	DPH5	1453	-345.1	4	Methyltransferase required for synthesis of diphthamide, which is a modified histidine residue of translation elongation factor 2 (Eft1p or Eft2p); not essential for viability; GFP-Dph5p fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000004162]
L	YLR173W	YLR173W	46	-122.3	4	Putative protein of unknown function [Source:SGD;Acc:S000004163]
L	YLR174W	IDP2	1782	-858.1	4	Cytosolic NADP-specific isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate; levels are elevated during growth on non-fermentable carbon sources and reduced during growth on glucose [Source:SGD;Acc:S000004164]
L	YLR175W	CBF5	3196	-630	4	Pseudouridine synthase catalytic subunit of box H/ACA small nucleolar ribonucleoprotein particles (snoRNPs), acts on both large and small rRNAs and on snRNA U2; mutations in human ortholog dyskerin cause the disorder dyskeratosis congenita [Source:SGD;Acc:S000004165]
L	YLR176C	RFX1	189	-175.1	4	Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins [Source:SGD;Acc:S000004166]
L	YLR177W	YLR177W	520	-294.1	4	Putative protein of unknown function; phosphorylated by Dbf2p-Mob1p in vitro; some strains contain microsatellite polymophisms at this locus; YLR177W is not an essential gene [Source:SGD;Acc:S000004167]
L	YLR178C	TFS1	1270	-398.9	4	Protein that interacts with and inhibits carboxypeptidase Y and Ira2p; phosphatidylethanolamine-binding protein (PEBP) family member; targets to vacuolar membranes during stationary phase; acetylated by NatB N-terminal acetyltransferase [Source:SGD;Acc:S000004168]
L	YLR179C	YLR179C	1943	-314.9	4	Protein of unknown function with similarity to Tfs1p; transcription is activated by paralogous proteins Yrm1p and Yrr1p along with proteins involved in multidrug resistance; GFP-tagged protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000004169]
L	YLR180W	SAM1	4374	-988.3	4	S-adenosylmethionine synthetase, catalyzes transfer of the adenosyl group of ATP to the sulfur atom of methionine; one of two differentially regulated isozymes (Sam1p and Sam2p) [Source:SGD;Acc:S000004170]
L	YLR181C	VTA1	555	-187.5	4	Multivesicular body (MVB) protein involved in endosomal protein sorting; regulates Vps4p activity by promoting its oligomerization; has an N-terminal Vps60- and Did2- binding domain, a linker region, and a C-terminal Vps4p binding domain [Source:SGD;Acc:S000004171]
L	YLR182W	SWI6	812	-706.5	4	Transcription cofactor, forms complexes with Swi4p and Mbp1p to regulate transcription at the G1/S transition; involved in meiotic gene expression; cell wall stress induces phosphorylation by Mpk1p, which regulates Swi6p localization [Source:SGD;Acc:S000004172]
L	YLR183C	TOS4	140	-101.4	4	Forkhead Associated domain containing protein and putative transcription factor found associated with chromatin; target of SBF transcription factor; expression is periodic and peaks in G1; similar to PLM2 [Source:SGD;Acc:S000004173]
L	YLR184W	YLR184W	7	-1.3	1	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004174]
L	YLR185W	RPL37A	1897	-159.8	4	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl37Bp and to rat L37 ribosomal protein [Source:SGD;Acc:S000004175]
L	YLR186W	EMG1	1436	-295.2	4	Member of the alpha/beta knot fold methyltransferase superfamily; required for maturation of 18S rRNA and for 40S ribosome production; interacts with RNA and with S-adenosylmethionine; associates with spindle/microtubules; forms homodimers [Source:SGD;Acc:S000004176]
L	YLR187W	SKG3	879	-337	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; potential Cdc28p substrate; similar to Caf120p and Skg4p [Source:SGD;Acc:S000004177]
L	YLR188W	MDL1	443	-219.3	4	Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, mediates export of peptides generated upon proteolysis of mitochondrial proteins, plays a role in the regulation of cellular resistance to oxidative stress [Source:SGD;Acc:S000004178]
L	YLR189C	ATG26	403	-391.3	4	UDP-glucose:sterol glucosyltransferase, conserved enzyme involved in synthesis of sterol glucoside membrane lipids; in contrast to ATG26 from P. pastoris, S. cerevisiae ATG26 is not involved in autophagy [Source:SGD;Acc:S000004179]
L	YLR190W	MMR1	342	-160.1	4	Phosphorylated protein of the mitochondrial outer membrane, localizes only to mitochondria of the bud; interacts with Myo2p to mediate mitochondrial distribution to buds; mRNA is targeted to the bud via the transport system involving She2p [Source:SGD;Acc:S000004180]
L	YLR191W	PEX13	199	-321.2	4	Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p [Source:SGD;Acc:S000004181]
L	YLR192C	HCR1	2213	-277.7	4	Dual function protein involved in translation initiation as a substoichiometric component (eIF3j) of translation initiation factor 3 (eIF3) and required for processing of 20S pre-rRNA; binds to eIF3 subunits Rpg1p and Prt1p and 18S rRNA [Source:SGD;Acc:S000004182]
L	YLR193C	UPS1	53	-91.5	4	Mitochondrial intermembrane space protein that regulates mitochondrial cardiolipin levels, null has defects in Mgm1p processing, integrity of mitochondrial inner membrane complexes, and mitochondrial morphology; ortholog of human PRELI [Source:SGD;Acc:S000004183]
L	YLR194C	YLR194C	21	-18.6	4	Structural constituent of the cell wall attached to the plasma membrane by a GPI-anchor; expression is upregulated in response to cell wall stress [Source:SGD;Acc:S000004184]
L	YLR195C	NMT1	1185	-507.8	4	N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction [Source:SGD;Acc:S000004185]
L	YLR196W	PWP1	2097	-636.8	4	Protein with WD-40 repeats involved in rRNA processing; associates with trans-acting ribosome biogenesis factors; similar to beta-transducin superfamily [Source:SGD;Acc:S000004186]
L	YLR197W	NOP56	3988	-935.8	4	Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects [Source:SGD;Acc:S000004187]
L	YLR198C	YLR198C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SIK1/YLR197W [Source:SGD;Acc:S000004188]
L	YLR199C	PBA1	592	-140.4	4	Protein involved in 20S proteasome assembly; forms a heterodimer with Add66p that binds to proteasome precursors; similar to human PAC1 constituent of the PAC1-PAC2 complex involved in proteasome assembly [Source:SGD;Acc:S000004189]
L	YLR200W	YKE2	1253	-140.8	4	Subunit of the heterohexameric Gim/prefoldin protein complex involved in the folding of alpha-tubulin, beta-tubulin, and actin [Source:SGD;Acc:S000004190]
L	YLR201C	COQ9	301	-118.4	4	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes [Source:SGD;Acc:S000004191]
L	YLR202C	YLR202C	4	-2.5	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YLR201C; ORF contains a putative intron [Source:SGD;Acc:S000004192]
L	YLR203C	MSS51	861	-397.5	4	Specific translational activator for the mitochondrial COX1 mRNA; loosely associated with the matrix face of the mitochondrial inner membrane; influences both COX1 mRNA translation and Cox1p assembly into cytochrome c oxidase [Source:SGD;Acc:S000004193]
L	YLR204W	QRI5	6	-2	2	Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA [Source:SGD;Acc:S000004194]
L	YLR205C	HMX1	69	-198.4	4	ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants [Source:SGD;Acc:S000004195]
L	YLR206W	ENT2	1457	-405.5	4	Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus [Source:SGD;Acc:S000004196]
L	YLR207W	HRD3	265	-306.1	4	Resident protein of the ER membrane that plays a central role in ER-associated protein degradation (ERAD), forms HRD complex with Hrd1p and ERAD determinants that engages in lumen to cytosol communication and coordination of ERAD events [Source:SGD;Acc:S000004197]
L	YLR208W	SEC13	2145	-623.6	4	Component of the Nup84 nuclear pore sub-complex, the Sec13p-Sec31p complex of the COPII vesicle coat, and the SEA (Seh1-associated) complex; required for vesicle formation in ER to Golgi transport and nuclear pore complex organization; the Nup84 sub  x has a role in transcription elongation [Source:SGD;Acc:S000004198]
L	YLR209C	PNP1	861	-407	4	Purine nucleoside phosphorylase, specifically metabolizes inosine and guanosine nucleosides; involved in the nicotinamide riboside salvage pathway [Source:SGD;Acc:S000004199]
L	YLR210W	CLB4	13	-21.7	2	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the G2/M transition; may be involved in DNA replication and spindle assembly; accumulates during S phase and G2, then targeted for ubiquitin-mediated degradation [Source:SGD;Acc:S000004200]
L	YLR211C	ATG38	109	-69.9	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR211C is not an essential gene; ORF contains an intron [Source:SGD;Acc:S000004201]
L	YLR212C	TUB4	318	-136.2	4	Gamma-tubulin, involved in nucleating microtubules from both the cytoplasmic and nuclear faces of the spindle pole body [Source:SGD;Acc:S000004202]
L	YLR213C	CRR1	16	-13.5	2	Putative glycoside hydrolase of the spore wall envelope; required for normal spore wall assembly, possibly for cross-linking between the glucan and chitosan layers; expressed during sporulation [Source:SGD;Acc:S000004203]
L	YLR214W	FRE1	675	-407.8	4	Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low copper and iron levels [Source:SGD;Acc:S000004204]
L	YLR215C	CDC123	438	-116.6	4	Protein involved in nutritional control of the cell cycle; regulates abundance of the translation initiation factor eIF2; ortholog of human D123 protein [Source:SGD;Acc:S000004205]
L	YLR216C	CPR6	2531	-564	4	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds to Hsp82p and contributes to chaperone activity [Source:SGD;Acc:S000004206]
L	YLR217W	YLR217W	2	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CPR6 [Source:SGD;Acc:S000004207]
L	YLR218C	COA4	147	-75.8	4	Twin Cx(9)C protein involved in cytochrome c oxidase assembly or stability; localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; interacts genetically with CYC1 and with cytochrome c oxidase assembly factors [Source:SGD;Acc:S000004208]
L	YLR219W	MSC3	1145	-460.8	4	Protein of unknown function, green fluorescent protein (GFP)-fusion protein localizes to the cell periphery; msc3 mutants are defective in directing meiotic recombination events to homologous chromatids; potential Cdc28p substrate [Source:SGD;Acc:S000004209]
L	YLR220W	CCC1	915	-235.1	4	Putative vacuolar Fe2+/Mn2+ transporter; suppresses respiratory deficit of yfh1 mutants, which lack the ortholog of mammalian frataxin, by preventing mitochondrial iron accumulation [Source:SGD;Acc:S000004210]
L	YLR221C	RSA3	537	-94	4	Protein with a likely role in ribosomal maturation, required for accumulation of wild-type levels of large (60S) ribosomal subunits; binds to the helicase Dbp6p in pre-60S ribosomal particles in the nucleolus [Source:SGD;Acc:S000004211]
L	YLR222C	UTP13	1356	-429.1	4	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [Source:SGD;Acc:S000004212]
L	YLR222C-A	YLR222C-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene IFH1 [Source:SGD;Acc:S000028568]
L	YLR223C	IFH1	323	-211.3	4	Coactivator that regulates transcription of ribosomal protein (RP) genes; recruited to RP gene promoters during optimal growth conditions via Fhl1p; subunit of CURI, a complex that coordinates RP production and pre-rRNA processing [Source:SGD;Acc:S000004213]
L	YLR224W	YLR224W	46	-41.9	4	F-box protein and component of SCF ubiquitin ligase complexes involved in ubiquitin-dependent protein catabolism; readily monoubiquitinated in vitro by SCF-Ubc4 complexes; YLR224W is not an essential gene [Source:SGD;Acc:S000004214]
L	YLR225C	YLR225C	545	-297.6	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR225C is not an essential gene [Source:SGD;Acc:S000004215]
L	YLR226W	BUR2	334	-117.6	4	Cyclin for the Sgv1p (Bur1p) protein kinase; Sgv1p and Bur2p comprise a CDK-cyclin complex involved in transcriptional regulation through its phosphorylation of the carboxy-terminal domain of the largest subunit of RNA polymerase II [Source:SGD;Acc:S000004216]
L	YLR227C	ADY4	16	-10.8	2	Structural component of the meiotic outer plaque, which is a membrane-organizing center that assembles on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane [Source:SGD;Acc:S000004217]
L	YLR227W-A	YLR227W-A	4675	-1737.6	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007375]
L	YLR227W-B	YLR227W-B	4962	-2368.3	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007376]
L	YLR228C	ECM22	210	-251.8	4	Sterol regulatory element binding protein, regulates transcription of sterol biosynthetic genes; contains Zn[2]-Cys[6] binuclear cluster; homologous to Upc2p; relocates from intracellular membranes to perinuclear foci on sterol depletion [Source:SGD;Acc:S000004218]
L	YLR229C	CDC42	1300	-225.6	4	Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins [Source:SGD;Acc:S000004219]
L	YLR230W	YLR230W	0	nf	1	Dubious open reading frame unlikely to encode a functional protein; overlaps 5' end of essential CDC42 gene which encodes a small Rho-like GTPase essential for establishment and maintenance of cell polarity [Source:SGD;Acc:S000004220]
L	YLR231C	BNA5	823	-429.6	4	Kynureninase, required for the de novo biosynthesis of NAD from tryptophan via kynurenine; expression regulated by Hst1p [Source:SGD;Acc:S000004221]
L	YLR232W	YLR232W	1	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene BNA5 [Source:SGD;Acc:S000004222]
L	YLR233C	EST1	36	-115.7	4	TLC1 RNA-associated factor involved in telomere length regulation as recruitment subunit of telomerase; has G-quadruplex promoting activity that is required for telomere elongation; possible role in activating telomere-bound Est2p-TLC1-RNA [Source:SGD;Acc:S000004223]
L	YLR234W	TOP3	42	-41.6	2	DNA Topoisomerase III, conserved protein that functions in a complex with Sgs1p and Rmi1p to relax single-stranded negatively-supercoiled DNA preferentially, involved in telomere stability and regulation of mitotic recombination [Source:SGD;Acc:S000004224]
L	YLR235C	YLR235C	2	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene TOP3 [Source:SGD;Acc:S000004225]
L	YLR236C	YLR236C	13	-1.6	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004226]
L	YLR237W	THI7	163	-174.3	4	Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia [Source:SGD;Acc:S000004227]
L	YLR238W	FAR10	187	-94.3	4	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far11p; potential Cdc28p substrate [Source:SGD;Acc:S000004228]
L	YLR239C	LIP2	201	-207.1	4	Lipoyl ligase, involved in the modification of mitochondrial enzymes by the attachment of lipoic acid groups [Source:SGD;Acc:S000004229]
L	YLR240W	VPS34	221	-268.2	4	Phosphatidylinositol 3-kinase responsible for the synthesis of phosphatidylinositol 3-phosphate; forms membrane-associated signal transduction complex with Vps15p to regulate protein sorting; activated by the GTP-bound form of Gpa1p [Source:SGD;Acc:S000004230]
L	YLR241W	CSC1	184	-120.5	4	Putative protein of unknown function, may be involved in detoxification [Source:SGD;Acc:S000004231]
L	YLR242C	ARV1	8	-31.5	2	Protein functioning in transport of glycosylphosphatidylinositol intermediates into ER lumen; required for normal intracellular sterol distribution; human ARV1 required for normal cholesterol and bile acid homeostasis; similar to Nup120p [Source:SGD;Acc:S000004232]
L	YLR243W	GPN3	395	-120.5	4	Putative protein of unknown function; YLR243W is an essential gene [Source:SGD;Acc:S000004233]
L	YLR244C	MAP1	2269	-444.5	4	Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map2p [Source:SGD;Acc:S000004234]
L	YLR245C	CDD1	303	-148.9	4	Cytidine deaminase; catalyzes the modification of cytidine to uridine in vitro but native RNA substrates have not been identified, localizes to both the nucleus and cytoplasm [Source:SGD;Acc:S000004235]
L	YLR246W	ERF2	9	-4.2	2	Subunit of a palmitoyltransferase, composed of Erf2p and Shr5p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; mutants partially mislocalize Ras2p to the vacuole [Source:SGD;Acc:S000004236]
L	YLR247C	IRC20	213	-319	4	Putative helicase; localizes to the mitochondrion and the nucleus; YLR247C is not an essential gene; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000004237]
L	YLR248W	RCK2	1549	-596.1	4	Protein kinase involved in the response to oxidative and osmotic stress; identified as suppressor of S. pombe cell cycle checkpoint mutations; similar to CaM (calmodulin) kinases [Source:SGD;Acc:S000004238]
L	YLR249W	YEF3	6054	-3920.6	4	Gamma subunit of translational elongation factor eEF1B, stimulates the binding of aminoacyl-tRNA (AA-tRNA) to ribosomes by releasing eEF1A (Tef1p/Tef2p) from the ribosomal complex; contains two ABC cassettes; binds and hydrolyzes ATP [Source:SGD;Acc:S000004239]
L	YLR250W	SSP120	952	-200.7	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000004240]
L	YLR251W	SYM1	43	-50.1	4	Protein required for ethanol metabolism; induced by heat shock and localized to the inner mitochondrial membrane; homologous to mammalian peroxisomal membrane protein Mpv17 [Source:SGD;Acc:S000004241]
L	YLR252W	YLR252W	5	-1.9	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene SYM1, a mitochondrial protein involved in ethanol metabolism [Source:SGD;Acc:S000004242]
L	YLR253W	MCP2	219	-240.3	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; transcription is periodic during the metabolic cycle; YLR253W is not an essential gene [Source:SGD;Acc:S000004243]
L	YLR254C	NDL1	14	-16.4	3	Homolog of nuclear distribution factor NudE, NUDEL; interacts with Pac1p and regulates dynein targeting to microtubule plus ends [Source:SGD;Acc:S000004244]
L	YLR255C	YLR255C	5	-3	2	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004245]
L	YLR256W	HAP1	455	-253.6	4	Zinc finger transcription factor involved in the complex regulation of gene expression in response to levels of heme and oxygen; the S288C sequence differs from other strain backgrounds due to a Ty1 insertion in the carboxy terminus [Source:SGD;Acc:S000004246]
L	YLR256W-A	YLR256W-A	4663	-1620.4	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007377]
L	YLR257W	YLR257W	1707	-478.8	4	Putative protein of unknown function [Source:SGD;Acc:S000004247]
L	YLR258W	GSY2	1518	-1309	4	Glycogen synthase, similar to Gsy1p; expression induced by glucose limitation, nitrogen starvation, heat shock, and stationary phase; activity regulated by cAMP-dependent, Snf1p and Pho85p kinases as well as by the Gac1p-Glc7p phosphatase [Source:SGD;Acc:S000004248]
L	YLR259C	HSP60	4715	-1919	4	Tetradecameric mitochondrial chaperonin required for ATP-dependent folding of precursor polypeptides and complex assembly; prevents aggregation and mediates protein refolding after heat shock; role in mtDNA transmission; phosphorylated [Source:SGD;Acc:S000004249]
L	YLR260W	LCB5	468	-250.2	4	Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules [Source:SGD;Acc:S000004250]
L	YLR261C	VPS63	2	-2.3	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene YPT6; deletion causes a vacuolar protein sorting defect [Source:SGD;Acc:S000004251]
L	YLR262C	YPT6	1366	-153.8	4	Rab family GTPase, Ras-like GTP binding protein involved in the secretory pathway, required for fusion of endosome-derived vesicles with the late Golgi, maturation of the vacuolar carboxypeptidase Y; has similarity to the human GTPase, Rab6 [Source:SGD;Acc:S000004252]
L	YLR262C-A	TMA7	1205	-137.5	4	Protein of unknown that associates with ribosomes; null mutant exhibits translation defects, altered polyribosome profiles, and resistance to the translation inhibitor anisomcyin [Source:SGD;Acc:S000007246]
L	YLR263W	RED1	43	-31.8	2	Protein component of the synaptonemal complex axial elements, involved in chromosome segregation during the first meiotic division; critical for coupling checkpoint signaling to SC formation; interacts with Hop1p, Mec3p and Ddc1p [Source:SGD;Acc:S000004253]
L	YLR264C-A	YLR264C-A	4	-4.6	2	Putative protein of unknown function [Source:SGD;Acc:S000028808]
L	YLR264W	RPS28B	2520	-170.9	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Ap and has similarity to rat S28 ribosomal protein [Source:SGD;Acc:S000004254]
L	YLR265C	NEJ1	107	-54.5	4	Protein involved in regulation of nonhomologous end joining; interacts with DNA ligase IV components Dnl4p and Lif1p; repressed by MAT heterozygosity; regulates cellular distribution of Lif1p [Source:SGD;Acc:S000004255]
L	YLR266C	PDR8	18	-22	2	Transcription factor; targets include ATP-binding cassette (ABC) transporters, major facilitator superfamily transporters, and other genes involved in the pleiotropic drug resistance (PDR) phenomenon [Source:SGD;Acc:S000004256]
L	YLR267W	BOP2	45	-85.7	4	Protein of unknown function [Source:SGD;Acc:S000004257]
L	YLR268W	SEC22	552	-161.4	4	R-SNARE protein; assembles into SNARE complex with Bet1p, Bos1p and Sed5p; cycles between the ER and Golgi complex; involved in anterograde and retrograde transport between the ER and Golgi; synaptobrevin homolog [Source:SGD;Acc:S000004258]
L	YLR269C	YLR269C	6	-3.2	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004259]
L	YLR270W	DCS1	1938	-574.2	4	Non-essential hydrolase involved in mRNA decapping, may function in a feedback mechanism to regulate deadenylation, contains pyrophosphatase activity and a HIT (histidine triad) motif; interacts with neutral trehalase Nth1p [Source:SGD;Acc:S000004260]
L	YLR271W	YLR271W	117	-88.6	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000004261]
L	YLR272C	YCS4	240	-270.6	4	Subunit of the condensin complex; required for establishment and maintenance of chromosome condensation, chromosome segregation, chromatin binding of condensin, tRNA gene clustering at the nucleolus, and silencing at the mating type locus [Source:SGD;Acc:S000004262]
L	YLR273C	PIG1	33	-74.8	4	Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase [Source:SGD;Acc:S000004263]
L	YLR274W	MCM5	933	-982.7	4	Component of the hexameric MCM complex, which is important for priming origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation when activated by Cdc7p-Dbf4p in S-phase [Source:SGD;Acc:S000004264]
L	YLR275W	SMD2	534	-136.2	4	Core Sm protein Sm D2; part of heteroheptameric complex (with Smb1p, Smd1p, Smd3p, Sme1p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm D2 [Source:SGD;Acc:S000004265]
L	YLR276C	DBP9	1441	-355.3	4	ATP-dependent RNA helicase of the DEAD-box family involved in biogenesis of the 60S ribosomal subunit [Source:SGD;Acc:S000004266]
L	YLR277C	YSH1	389	-233.7	4	Putative endoribonuclease, subunit of the mRNA cleavage and polyadenylation specificity complex; required for 3' processing, splicing, and transcriptional termination of mRNAs and snoRNAs [Source:SGD;Acc:S000004267]
L	YLR278C	YLR278C	410	-233.7	4	Zinc-cluster protein; GFP-fusion protein localizes to the nucleus; mutant shows moderate growth defect on caffeine; has a prion-domain like fragment that increases frequency of [URE3]; YLR278C is not an essential gene [Source:SGD;Acc:S000004268]
L	YLR279W	YLR279W	4	-1.7	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004269]
L	YLR280C	YLR280C	7	-2.3	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004270]
L	YLR281C	YLR281C	23	-40.3	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR281C is not an essential gene [Source:SGD;Acc:S000004271]
L	YLR282C	YLR282C	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition [Source:SGD;Acc:S000004272]
L	YLR283W	YLR283W	85	-133.7	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YLR283W is not an essential gene [Source:SGD;Acc:S000004273]
L	YLR284C	ECI1	210	-162.8	4	Peroxisomal delta3,delta2-enoyl-CoA isomerase, hexameric protein that converts 3-hexenoyl-CoA to trans-2-hexenoyl-CoA, essential for the beta-oxidation of unsaturated fatty acids, oleate-induced [Source:SGD;Acc:S000004274]
L	YLR285C-A	YLR285C-A	0	nf	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028569]
L	YLR285W	NNT1	559	-132.6	4	S-adenosylmethionine-dependent methyltransferase; has a role in rDNA silencing and in lifespan determination [Source:SGD;Acc:S000004275]
L	YLR286C	CTS1	582	-158.6	4	Endochitinase, required for cell separation after mitosis; transcriptional activation during the G1 phase of the cell cycle is mediated by transcription factor Ace2p [Source:SGD;Acc:S000004276]
L	YLR286W-A	YLR286W-A	2	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CTS1 [Source:SGD;Acc:S000028679]
L	YLR287C	YLR287C	622	-229.9	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLR287C is not an essential gene [Source:SGD;Acc:S000004277]
L	YLR287C-A	RPS30A	2425	-177.4	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Bp and has similarity to rat S30 ribosomal protein [Source:SGD;Acc:S000004278]
L	YLR288C	MEC3	86	-80.6	4	DNA damage and meiotic pachytene checkpoint protein; subunit of a heterotrimeric complex (Rad17p-Mec3p-Ddc1p) that forms a sliding clamp, loaded onto partial duplex DNA by a clamp loader complex; homolog of human and S. pombe Hus1 [Source:SGD;Acc:S000004279]
L	YLR289W	GUF1	127	-215.2	4	Mitochondrial matrix GTPase that associates with mitochondrial ribosomes; important for translation under temperature and nutrient stress; may have a role in translational fidelity; similar to bacterial LepA elongation factor [Source:SGD;Acc:S000004280]
L	YLR290C	YLR290C	407	-230.2	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR290C is not an essential gene [Source:SGD;Acc:S000004281]
L	YLR291C	GCD7	1035	-352.9	4	Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression [Source:SGD;Acc:S000004282]
L	YLR292C	SEC72	577	-154.7	4	Non-essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER [Source:SGD;Acc:S000004283]
L	YLR293C	GSP1	3808	-527.7	4	Ran GTPase, GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; regulated by Srm1p, Rna1p, Yrb1p, Yrb2p, Yrp4p, Yrb30p, Cse1p and Kap95p; yeast Gsp2p homolog [Source:SGD;Acc:S000004284]
L	YLR294C	YLR294C	1	-1.5	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ATP14 [Source:SGD;Acc:S000004285]
L	YLR295C	ATP14	968	-216.2	4	Subunit h of the F0 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis [Source:SGD;Acc:S000004286]
L	YLR296W	YLR296W	3	-1.9	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004287]
L	YLR297W	YLR297W	23	-23.3	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YLR297W is not an essential gene; induced by treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000004288]
L	YLR298C	YHC1	148	-134.1	4	Component of the U1 snRNP complex required for pre-mRNA splicing; putative ortholog of human U1C protein, which is involved in formation of a complex between U1 snRNP and the pre-mRNA 5' splice site [Source:SGD;Acc:S000004289]
L	YLR299C-A	YLR299C-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ECM38 [Source:SGD;Acc:S000028680]
L	YLR299W	ECM38	293	-250.7	4	Gamma-glutamyltranspeptidase, major glutathione-degrading enzyme; involved in detoxification of electrophilic xenobiotics; expression induced mainly by nitrogen starvation [Source:SGD;Acc:S000004290]
L	YLR300W	EXG1	1615	-672.5	4	Major exo-1,3-beta-glucanase of the cell wall, involved in cell wall beta-glucan assembly; exists as three differentially glycosylated isoenzymes [Source:SGD;Acc:S000004291]
L	YLR301W	HRI1	1999	-430.2	4	Protein of unknown function that interacts with Sec72p and Hrr25p [Source:SGD;Acc:S000004292]
L	YLR302C	YLR302C	3	-2.2	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004293]
L	YLR303W	MET17	2232	-1115.6	4	Methionine and cysteine synthase (O-acetyl homoserine-O-acetyl serine sulfhydrylase), required for sulfur amino acid synthesis [Source:SGD;Acc:S000004294]
L	YLR304C	ACO1	3488	-2100.8	4	Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy [Source:SGD;Acc:S000004295]
L	YLR305C	STT4	737	-796.5	4	Phosphatidylinositol-4-kinase that functions in the Pkc1p protein kinase pathway; required for normal vacuole morphology, cell wall integrity, and actin cytoskeleton organization [Source:SGD;Acc:S000004296]
L	YLR306W	UBC12	112	-56.1	4	Enzyme that mediates the conjugation of Rub1p, a ubiquitin-like protein, to other proteins; related to E2 ubiquitin-conjugating enzymes [Source:SGD;Acc:S000004297]
L	YLR307C-A	YLR307C-A	17	-71.4	3	Putative protein of unknown function [Source:SGD;Acc:S000028525]
L	YLR307W	CDA1	6	-10.1	2	Chitin deacetylase, together with Cda2p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall [Source:SGD;Acc:S000004298]
L	YLR308W	CDA2	27	-14.7	4	Chitin deacetylase, together with Cda1p involved in the biosynthesis ascospore wall component, chitosan; required for proper rigidity of the ascospore wall [Source:SGD;Acc:S000004299]
L	YLR309C	IMH1	1114	-740.7	4	Protein involved in vesicular transport, mediates transport between an endosomal compartment and the Golgi, contains a Golgi-localization (GRIP) domain that interacts with activated Arl1p-GTP to localize Imh1p to the Golgi [Source:SGD;Acc:S000004300]
L	YLR310C	CDC25	842	-754	4	Membrane bound guanine nucleotide exchange factor (GEF or GDP-release factor); indirectly regulates adenylate cyclase through activation of Ras1p and Ras2p by stimulating the exchange of GDP for GTP; required for progression through G1 [Source:SGD;Acc:S000004301]
L	YLR311C	YLR311C	7	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004302]
L	YLR312C	YLR312C	48	-112.5	4	Putative protein of unknown function [Source:SGD;Acc:S000004303]
L	YLR312W-A	MRPL15	699	-134.4	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000004304]
L	YLR313C	SPH1	40	-73.5	2	Protein involved in shmoo formation and bipolar bud site selection; homologous to Spa2p, localizes to sites of polarized growth in a cell cycle dependent- and Spa2p-dependent manner, interacts with MAPKKs Mkk1p, Mkk2p, and Ste7p [Source:SGD;Acc:S000004305]
L	YLR314C	CDC3	2480	-1392.9	4	Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble with other septins into rod-like complexes that can associate with other rods to form filament polymers; septin rings at the mother-bud nec  as scaffolds for recruiting factors needed for cell division and as barriers to prevent diffusion of specific proteins between mother and daughter cells [Source:SGD;Acc:S000004306]
L	YLR315W	NKP2	35	-79.5	4	Non-essential kinetochore protein, subunit of the Ctf19 central kinetochore complex (Ctf19p-Mcm21p-Okp1p-Mcm22p-Mcm16p-Ctf3p-Chl4p-Mcm19p-Nkp1p-Nkp2p-Ame1p-Mtw1p) [Source:SGD;Acc:S000004307]
L	YLR316C	TAD3	103	-87.7	4	Subunit of tRNA-specific adenosine-34 deaminase, forms a heterodimer with Tad2p that converts adenosine to inosine at the wobble position of several tRNAs [Source:SGD;Acc:S000004308]
L	YLR317W	YLR317W	3	-1.1	1	Dubious open reading frame; may be part of a bicistronic transcript with NKP2/YLR315W; overlaps the verified ORF TAD3/YLR316C [Source:SGD;Acc:S000004309]
L	YLR318W	EST2	20	-11.2	2	Reverse transcriptase subunit of the telomerase holoenzyme, essential for telomerase core catalytic activity, involved in other aspects of telomerase assembly and function; mutations in human homolog are associated with aplastic anemia [Source:SGD;Acc:S000004310]
L	YLR319C	BUD6	850	-446.2	4	Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate [Source:SGD;Acc:S000004311]
L	YLR320W	MMS22	38	-12.1	2	Protein that acts with Mms1p in a repair pathway that may be involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; required for accurate meiotic chromosome segregation [Source:SGD;Acc:S000004312]
L	YLR321C	SFH1	860	-206.4	4	Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog [Source:SGD;Acc:S000004313]
L	YLR322W	VPS65	0	nf	1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 75% of ORF overlaps the verified gene SFH1; deletion causes a vacuolar protein sorting defect and blocks anaerobic growth [Source:SGD;Acc:S000004314]
L	YLR323C	CWC24	223	-88.9	4	Essential protein, component of a complex containing Cef1p; has similarity to S. pombe Cwf24p [Source:SGD;Acc:S000004315]
L	YLR324W	PEX30	794	-717.9	4	Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p [Source:SGD;Acc:S000004316]
L	YLR325C	RPL38	3127	-327.9	4	Protein component of the large (60S) ribosomal subunit, has similarity to rat L38 ribosomal protein [Source:SGD;Acc:S000004317]
L	YLR326W	YLR326W	194	-120.8	4	Putative protein of unknown function, predicted to be palmitoylated [Source:SGD;Acc:S000004318]
L	YLR327C	TMA10	368	-140.9	4	Protein of unknown function that associates with ribosomes; putative homolog of the F1F0-ATPase synthase regulator Stf2p [Source:SGD;Acc:S000004319]
L	YLR328W	NMA1	967	-319.8	4	Nicotinic acid mononucleotide adenylyltransferase, involved in pathways of NAD biosynthesis, including the de novo, NAD(+) salvage, and nicotinamide riboside salvage pathways [Source:SGD;Acc:S000004320]
L	YLR329W	REC102	1	-2.4	2	Protein involved in early stages of meiotic recombination; required for chromosome synapsis; forms a complex with Rec104p and Spo11p necessary during the initiation of recombination [Source:SGD;Acc:S000004321]
L	YLR330W	CHS5	1770	-583.7	4	Component of the exomer complex, which also contains Csh6p, Bch1p, Bch2p, and Bud7p and is involved in export of selected proteins, such as chitin synthase Chs3p, from the Golgi to the plasma membrane [Source:SGD;Acc:S000004322]
L	YLR331C	JIP3	14	-1.6	1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2 [Source:SGD;Acc:S000004323]
L	YLR332W	MID2	308	-58	4	O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p [Source:SGD;Acc:S000004324]
L	YLR333C	RPS25B	3312	-318.3	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps25Ap and has similarity to rat S25 ribosomal protein [Source:SGD;Acc:S000004325]
L	YLR334C	YLR334C	5	-5.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps a stand-alone long terminal repeat sequence whose presence indicates a retrotransposition event occurred here [Source:SGD;Acc:S000004326]
L	YLR335W	NUP2	2549	-794.1	4	Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization [Source:SGD;Acc:S000004327]
L	YLR336C	SGD1	681	-315.6	4	Essential nuclear protein, required for biogenesis of the small ribosomal subunit; has a possible role in the osmoregulatory glycerol response; putative homolog of human NOM1 which is implicated in acute myeloid leukemia [Source:SGD;Acc:S000004328]
L	YLR337C	VRP1	1124	-328.6	4	Proline-rich actin-associated protein involved in cytoskeletal organization and cytokinesis; related to mammalian Wiskott-Aldrich syndrome protein (WASP)-interacting protein (WIP) [Source:SGD;Acc:S000004329]
L	YLR338W	OPI9	14	-19.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF VRP1/YLR337C [Source:SGD;Acc:S000004330]
L	YLR339C	YLR339C	12	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential gene RPP0 [Source:SGD;Acc:S000004331]
L	YLR340W	RPP0	5117	-729.9	4	Conserved ribosomal protein P0 of the ribosomal stalk, which is involved in interaction between translational elongation factors and the ribosome; similar to rat P0, human P0, and E. coli L10e; phosphorylated on serine 302 [Source:SGD;Acc:S000004332]
L	YLR341W	SPO77	8	-2.1	2	Meiosis-specific protein of unknown function, required for spore wall formation during sporulation; dispensable for both nuclear divisions during meiosis [Source:SGD;Acc:S000004333]
L	YLR342W	FKS1	3097	-1501.1	4	Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling [Source:SGD;Acc:S000004334]
L	YLR342W-A	YLR342W-A	1	0	1	Putative protein of unknown function [Source:SGD;Acc:S000028571]
L	YLR343W	GAS2	27	-10.4	2	1,3-beta-glucanosyltransferase, involved with Gas4p in spore wall assembly; has similarity to Gas1p [Source:SGD;Acc:S000004335]
L	YLR344W	RPL26A	3789	-350.7	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl26Bp and has similarity to E. coli L24 and rat L26 ribosomal proteins; binds to 5.8S rRNA [Source:SGD;Acc:S000004336]
L	YLR345W	YLR345W	558	-470.3	4	Similar to 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase enzymes responsible for the metabolism of fructoso-2,6-bisphosphate; mRNA expression is repressed by the Rfx1p-Tup1p-Ssn6p repressor complex; YLR345W is not an essential gene [Source:SGD;Acc:S000004337]
L	YLR346C	YLR346C	3	-10.2	2	Putative protein of unknown function found in mitochondria; expression is regulated by transcription factors involved in pleiotropic drug resistance, Pdr1p and Yrr1p; YLR346C is not an essential gene [Source:SGD;Acc:S000004338]
L	YLR347C	KAP95	2361	-860.2	4	Karyopherin beta, forms a complex with Srp1p/Kap60p; interacts with nucleoporins to mediate nuclear import of NLS-containing cargo proteins via the nuclear pore complex; regulates PC biosynthesis; GDP-to-GTP exchange factor for Gsp1p [Source:SGD;Acc:S000004339]
L	YLR347W-A	YLR347W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF KAP95/YLR347C [Source:SGD;Acc:S000028681]
L	YLR348C	DIC1	386	-163.1	4	Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix [Source:SGD;Acc:S000004340]
L	YLR349W	YLR349W	7	-5.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified ORF DIC1/YLR348C [Source:SGD;Acc:S000004341]
L	YLR350W	ORM2	483	-140.8	4	Evolutionarily conserved protein, similar to Orm1p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control [Source:SGD;Acc:S000004342]
L	YLR351C	NIT3	1211	-278.7	4	Nit protein, one of two proteins in S. cerevisiae with similarity to the Nit domain of NitFhit from fly and worm and to the mouse and human Nit protein which interacts with the Fhit tumor suppressor; nitrilase superfamily member [Source:SGD;Acc:S000004343]
L	YLR352W	YLR352W	207	-243.3	4	Putative protein of unknown function with similarity to F-box proteins; interacts with Skp1p and Cdc53p; YLR352W is not an essential gene [Source:SGD;Acc:S000004344]
L	YLR353W	BUD8	121	-46.3	4	Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole [Source:SGD;Acc:S000004345]
L	YLR354C	TAL1	3317	-1162.8	4	Transaldolase, enzyme in the non-oxidative pentose phosphate pathway; converts sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate to erythrose 4-phosphate and fructose 6-phosphate [Source:SGD;Acc:S000004346]
L	YLR355C	ILV5	4250	-1529.6	4	Bifunctional acetohydroxyacid reductoisomerase and mtDNA binding protein; involved in branched-chain amino acid biosynthesis and maintenance of wild-type mitochondrial DNA; found in mitochondrial nucleoids [Source:SGD;Acc:S000004347]
L	YLR356W	ATG33	520	-140.5	4	Mitochondrial mitophagy-specific protein; required primarily for mitophagy induced at the post-log phase; not required for other types of selective autophagy or macroautophagy; conserved within fungi, but not in higher eukaryotes [Source:SGD;Acc:S000004348]
L	YLR357W	RSC2	1041	-574.9	4	Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; involved in telomere maintenance [Source:SGD;Acc:S000004349]
L	YLR358C	YLR358C	3	-1.7	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RSC2/YLR357W [Source:SGD;Acc:S000004350]
L	YLR359W	ADE13	2561	-1921.1	4	Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency [Source:SGD;Acc:S000004351]
L	YLR360W	VPS38	32	-174.9	4	Part of a Vps34p phosphatidylinositol 3-kinase complex that functions in carboxypeptidase Y (CPY) sorting; binds Vps30p and Vps34p to promote production of phosphatidylinositol 3-phosphate (PtdIns3P) which stimulates kinase activity [Source:SGD;Acc:S000004352]
L	YLR361C	DCR2	179	-183.3	4	Phosphoesterase involved in downregulation of the unfolded protein response, at least in part via dephosphorylation of Ire1p; dosage-dependent positive regulator of the G1/S phase transition through control of the timing of START [Source:SGD;Acc:S000004353]
L	YLR361C-A	YLR361C-A	339	-58.6	4	Putative protein of unknown function [Source:SGD;Acc:S000028845]
L	YLR362W	STE11	551	-1483.5	4	Signal transducing MEK kinase involved in pheromone response and pseudohyphal/invasive growth pathways where it phosphorylates Ste7p, and the high osmolarity response pathway, via phosphorylation of Pbs2p; regulated by Ste20p and Ste50p [Source:SGD;Acc:S000004354]
L	YLR363C	NMD4	95	-33.5	4	Protein interacting with Nam7p, may be involved in the nonsense-mediated mRNA decay pathway [Source:SGD;Acc:S000004355]
L	YLR363W-A	YLR363W-A	233	-30.6	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus [Source:SGD;Acc:S000007620]
L	YLR364C-A	YLR364C-A	3	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR366W [Source:SGD;Acc:S000028846]
L	YLR364W	GRX8	464	-57.2	4	Glutaredoxin that employs a dithiol mechanism of catalysis; monomeric; activity is low and null mutation does not affect sensitivity to oxidative stress; GFP-fusion protein localizes to the cytoplasm; expression strongly induced by arsenic [Source:SGD;Acc:S000004356]
L	YLR365W	YLR365W	9	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious gene YLR364C-A; YLR365W is not an essential gene [Source:SGD;Acc:S000004357]
L	YLR366W	YLR366W	3	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YLR364C-A [Source:SGD;Acc:S000004358]
L	YLR367W	RPS22B	4168	-653.3	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps22Ap and has similarity to E. coli S8 and rat S15a ribosomal proteins [Source:SGD;Acc:S000004359]
L	YLR368W	MDM30	49	-352.9	4	F-box component of an SCF ubiquitin protein ligase complex; associates with and is required for Fzo1p ubiquitination and for mitochondria fusion; stimulates nuclear export of specific mRNAs; promotes ubiquitin-mediated degradation of Gal4p in some strains [Source:SGD;Acc:S000004360]
L	YLR369W	SSQ1	852	-323.6	4	Mitochondrial hsp70-type molecular chaperone, required for assembly of iron/sulfur clusters into proteins at a step after cluster synthesis, and for maturation of Yfh1p, which is a homolog of human frataxin implicated in Friedreich's ataxia [Source:SGD;Acc:S000004361]
L	YLR370C	ARC18	1152	-165.6	4	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches [Source:SGD;Acc:S000004362]
L	YLR371W	ROM2	608	-846.1	4	GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF [Source:SGD;Acc:S000004363]
L	YLR372W	ELO3	1658	-198.4	4	Elongase, involved in fatty acid and sphingolipid biosynthesis; synthesizes very long chain 20-26-carbon fatty acids from C18-CoA primers; involved in regulation of sphingolipid biosynthesis [Source:SGD;Acc:S000004364]
L	YLR373C	VID22	383	-299.2	4	Glycosylated integral membrane protein localized to the plasma membrane; plays a role in fructose-1,6-bisphosphatase (FBPase) degradation; involved in FBPase transport from the cytosol to Vid (vacuole import and degradation) vesicles [Source:SGD;Acc:S000004365]
L	YLR374C	YLR374C	40	-7.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W [Source:SGD;Acc:S000004366]
L	YLR375W	STP3	203	-89.7	4	Zinc-finger protein of unknown function, possibly involved in pre-tRNA splicing and in uptake of branched-chain amino acids [Source:SGD;Acc:S000004367]
L	YLR376C	PSY3	33	-65.6	4	Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function; deletion of PSY3 results in a mutator phenotype; deletion increases sensitivity to anticancer drugs oxaliplatin and cisplatin but   tomycin C [Source:SGD;Acc:S000004368]
L	YLR377C	FBP1	354	-1052.8	4	Fructose-1,6-bisphosphatase, key regulatory enzyme in the gluconeogenesis pathway, required for glucose metabolism; undergoes either proteasome-mediated or autophagy-mediated degradation depending on growth conditions; interacts with Vid30p [Source:SGD;Acc:S000004369]
L	YLR378C	SEC61	1605	-316.8	4	Essential subunit of Sec61 complex (Sec61p, Sbh1p, and Sss1p); forms a channel for SRP-dependent protein import and retrograde transport of misfolded proteins out of the ER; with Sec63 complex allows SRP-independent protein import into ER [Source:SGD;Acc:S000004370]
L	YLR379W	YLR379W	4	-2.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the essential ORF SEC61/YLR378C [Source:SGD;Acc:S000004371]
L	YLR380W	CSR1	1283	-342.7	4	Phosphatidylinositol transfer protein with a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance [Source:SGD;Acc:S000004372]
L	YLR381W	CTF3	67	-89.2	4	Outer kinetochore protein that forms a complex with Mcm16p and Mcm22p; may bind the kinetochore to spindle microtubules [Source:SGD;Acc:S000004373]
L	YLR382C	NAM2	348	-358.3	4	Mitochondrial leucyl-tRNA synthetase, also has a direct role in splicing of several mitochondrial group I introns; indirectly required for mitochondrial genome maintenance [Source:SGD;Acc:S000004374]
L	YLR383W	SMC6	170	-310	4	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; homologous to S. pombe rad18 [Source:SGD;Acc:S000004375]
L	YLR384C	IKI3	1754	-961.5	4	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; maintains structural integrity of Elongator; homolog of human IKAP, mutations in which cause familial dysautonomia (FD) [Source:SGD;Acc:S000004376]
L	YLR385C	SWC7	84	-456.7	4	Protein of unknown function, component of the Swr1p complex that incorporates Htz1p into chromatin [Source:SGD;Acc:S000004377]
L	YLR386W	VAC14	621	-459.1	4	Protein involved in regulated synthesis of PtdIns(3,5)P(2), in control of trafficking of some proteins to the vacuole lumen via the MVB, and in maintenance of vacuole size and acidity; interacts with Fig4p; activator of Fab1p [Source:SGD;Acc:S000004378]
L	YLR387C	REH1	611	-236.2	4	Cytoplasmic 60S subunit biogenesis factor, associates with pre-60S particles; similar to Rei1p and shares partially redundant function in cytoplasmic 60S subunit maturation; contains dispersed C2H2 zinc finger domains [Source:SGD;Acc:S000004379]
L	YLR388W	RPS29A	2481	-146	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps29Bp and has similarity to rat S29 and E. coli S14 ribosomal proteins [Source:SGD;Acc:S000004380]
L	YLR389C	STE23	1272	-751.1	4	Metalloprotease involved, with homolog Axl1p, in N-terminal processing of pro-a-factor to the mature form; expressed in both haploids and diploids; member of the insulin-degrading enzyme family [Source:SGD;Acc:S000004381]
L	YLR390W	ECM19	271	-58.3	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004382]
L	YLR390W-A	CCW14	1247	-250.2	4	Covalently linked cell wall glycoprotein, present in the inner layer of the cell wall [Source:SGD;Acc:S000006429]
L	YLR392C	ART10	200	-182.4	4	Protein of unknown function that contains 2 PY motifs and is ubiquinated by Rsp5p; overexpression confers resistance to arsenite; green fluorescent protein (GFP)-fusion protein localizes it to the cytoplasm; non-essential gene [Source:SGD;Acc:S000004384]
L	YLR393W	ATP10	267	-161.2	4	Mitochondrial inner membrane protein required for assembly of the F0 sector of mitochondrial F1F0 ATP synthase, interacts genetically with ATP6 [Source:SGD;Acc:S000004385]
L	YLR394W	CST9	26	-101.8	2	SUMO E3 ligase; required for synaptonemal complex formation; localizes to synapsis initiation sites on meiotic chromosomes; potential Cdc28p substrate [Source:SGD;Acc:S000004386]
L	YLR395C	COX8	212	-64.7	4	Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain [Source:SGD;Acc:S000004387]
L	YLR396C	VPS33	387	-231.3	4	ATP-binding protein that is a subunit of the HOPS complex and of the CORVET tethering complex; essential for protein sorting, vesicle docking and fusion at the vacuole [Source:SGD;Acc:S000004388]
L	YLR397C	AFG2	826	-426.9	4	ATPase of the CDC48/PAS1/SEC18 (AAA) family, forms a hexameric complex; is essential for pre-60S maturation and release of several preribosome maturation factors; may be involved in degradation of aberrant mRNAs [Source:SGD;Acc:S000004389]
L	YLR398C	SKI2	1181	-759	4	Ski complex component and putative RNA helicase, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay [Source:SGD;Acc:S000004390]
L	YLR399C	BDF1	1343	-411.1	4	Protein involved in transcription initiation at TATA-containing promoters; associates with the basal transcription factor TFIID; contains two bromodomains; corresponds to the C-terminal region of mammalian TAF1; redundant with Bdf2p [Source:SGD;Acc:S000004391]
L	YLR399W-A	YLR399W-A	6	-2.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the characterized ORF BDF1/YLR399C [Source:SGD;Acc:S000028682]
L	YLR400W	YLR400W	2	-3.3	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004392]
L	YLR401C	DUS3	936	-592.7	4	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region [Source:SGD;Acc:S000004393]
L	YLR402W	YLR402W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004394]
L	YLR403W	SFP1	373	-89.4	4	Transcription factor that controls expression of ribosome biogenesis genes in response to nutrients and stress, regulates G2/M transitions during mitotic cell cycle and DNA-damage response, modulates cell size; regulated by TORC1 and Mrs6p; can form  ISP+] prion [Source:SGD;Acc:S000004395]
L	YLR404W	FLD1	45	-90.6	4	Seipin protein involved in lipid droplet morphology, number, and size; proposed to be involved in lipid metabolism; related to the human BSCL2 which is associated with lipodystrophy [Source:SGD;Acc:S000004396]
L	YLR405W	DUS4	169	-189.4	4	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p [Source:SGD;Acc:S000004397]
L	YLR406C	RPL31B	3579	-560.9	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl31Ap and has similarity to rat L31 ribosomal protein; associates with the karyopherin Sxm1p; loss of both Rpl31p and Rpl39p confers lethality [Source:SGD;Acc:S000004398]
L	YLR406C-A	YLR406C-A	2	-3.4	2	Putative protein of unknown function [Source:SGD;Acc:S000028683]
L	YLR407W	YLR407W	351	-83.9	4	Putative protein of unknown function; null mutant displays elongated buds and a large fraction of budded cells have only one nucleus [Source:SGD;Acc:S000004399]
L	YLR408C	BLS1	22	-24	3	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to the endosome; YLR408C is not an essential gene [Source:SGD;Acc:S000004400]
L	YLR409C	UTP21	1127	-406.5	4	Subunit of U3-containing 90S preribosome and Small Subunit (SSU) processome complexes involved in production of 18S rRNA and assembly of small ribosomal subunit; synthetic defect with STI1 Hsp90 cochaperone; human homolog linked to glaucoma [Source:SGD;Acc:S000004401]
L	YLR410W	VIP1	2061	-1218.8	4	Inositol hexakisphosphate (IP6) and inositol heptakisphosphate (IP7) kinase; IP7 production is important for phosphate signaling; involved in cortical actin cytoskeleton function, and invasive pseudohyphal growth analogous to S. pombe asp1 [Source:SGD;Acc:S000004402]
L	YLR410W-A	YLR410W-A	1072	-378	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007379]
L	YLR410W-B	YLR410W-B	2381	-831	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007380]
L	YLR411W	CTR3	46	-133.4	4	High-affinity copper transporter of the plasma membrane, acts as a trimer; gene is disrupted by a Ty2 transposon insertion in many laboratory strains of S. cerevisiae [Source:SGD;Acc:S000004403]
L	YLR412C-A	YLR412C-A	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000028572]
L	YLR412W	BER1	206	-132.4	4	Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene [Source:SGD;Acc:S000004404]
L	YLR413W	INA1	1140	-489.5	4	Putative protein of unknown function; YLR413W is not an essential gene [Source:SGD;Acc:S000004405]
L	YLR414C	PUN1	293	-53.5	4	Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress [Source:SGD;Acc:S000004406]
L	YLR415C	YLR415C	6	-2.2	2	Putative protein of unknown function; YLR415C is not an essential gene [Source:SGD;Acc:S000004407]
L	YLR416C	YLR416C	4	-2.4	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004408]
L	YLR417W	VPS36	150	-215.4	4	Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome [Source:SGD;Acc:S000004409]
L	YLR418C	CDC73	1267	-353.4	4	Component of the Paf1p complex; binds to and modulates the activity of RNA polymerases I and II; required for expression of certain genes, modification of some histones, and telomere maintenance; involved in transcription elongation as demonstrated    G-less-based run-on (GLRO) assay [Source:SGD;Acc:S000004410]
L	YLR419W	YLR419W	911	-649.5	4	Putative helicase with limited sequence similarity to human Rb protein; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YLR419W is not an essential gene [Source:SGD;Acc:S000004411]
L	YLR420W	URA4	1457	-537.9	4	Dihydroorotase, catalyzes the third enzymatic step in the de novo biosynthesis of pyrimidines, converting carbamoyl-L-aspartate into dihydroorotate [Source:SGD;Acc:S000004412]
L	YLR421C	RPN13	1831	-114.8	4	Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability [Source:SGD;Acc:S000004413]
L	YLR422W	YLR422W	275	-430.7	4	Protein of unknown function with similarity to human DOCK proteins (guanine nucleotide exchange factors); interacts with Ino4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, YLR422W is not an essential protein [Source:SGD;Acc:S000004414]
L	YLR423C	ATG17	95	-248.4	4	Scaffold protein responsible for phagophore assembly site organization; regulatory subunit of an autophagy-specific complex that includes Atg1p and Atg13p; stimulates Atg1p kinase activity; human ortholog RB1CC1/FIP200 interacts with p53, which inhi  utophagy in human cells [Source:SGD;Acc:S000004415]
L	YLR424W	SPP382	145	-191	4	Essential protein that forms a dimer with Ntr2p; also forms a trimer, with Ntr2p and Prp43p, that is involved in spliceosome disassembly; found also in a multisubunit complex with the splicing factor Clf1p; suppressor of prp38-1 mutation [Source:SGD;Acc:S000004416]
L	YLR425W	TUS1	173	-209	4	Guanine nucleotide exchange factor (GEF) that functions to modulate Rho1p activity as part of the cell integrity signaling pathway; multicopy suppressor of tor2 mutation and ypk1 ypk2 double mutation; potential Cdc28p substrate [Source:SGD;Acc:S000004417]
L	YLR426W	TDA5	73	-58.3	4	Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; proposed to be involved in resistance to mechlorethamine and streptozotocin; null mutant sensitive to expression of top1-T722A allele [Source:SGD;Acc:S000004418]
L	YLR427W	MAG2	262	-176.2	4	Cytoplasmic protein of unknown function; induced in response to mycotoxin patulin; ubiquitinated protein similar to the human ring finger motif protein RNF10; predicted to be involved in repair of alkylated DNA due to interaction with MAG1 [Source:SGD;Acc:S000004419]
L	YLR428C	YLR428C	3	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CRN1 [Source:SGD;Acc:S000004420]
L	YLR429W	CRN1	2137	-617	4	Coronin, cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly [Source:SGD;Acc:S000004421]
L	YLR430W	SEN1	977	-675.1	4	Presumed helicase required for RNA polymerase II transcription termination and processing of RNAs; homolog of Senataxin which causes Ataxia-Oculomotor Apraxia 2 and a dominant form of amyotrophic lateral sclerosis [Source:SGD;Acc:S000004422]
L	YLR431C	ATG23	170	-123.4	4	Peripheral membrane protein required for the cytoplasm-to-vacuole targeting (Cvt) pathway and efficient macroautophagy; cycles between the phagophore assembly site (PAS) and non-PAS locations; forms a complex with Atg9p and Atg27p [Source:SGD;Acc:S000004423]
L	YLR432W	IMD3	3712	-1715.1	4	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed [Source:SGD;Acc:S000004424]
L	YLR433C	CNA1	728	-942.7	4	Calcineurin A; one isoform (the other is CMP2) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 [Source:SGD;Acc:S000004425]
L	YLR434C	YLR434C	1	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF TSR2/YLR435W [Source:SGD;Acc:S000004426]
L	YLR435W	TSR2	391	-96.7	4	Protein with a potential role in pre-rRNA processing [Source:SGD;Acc:S000004427]
L	YLR436C	ECM30	417	-365.5	4	Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants have abormal relative levels of mannose and glucose and have Gap1p sorting and transport defects; (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000004428]
L	YLR437C	DIF1	74	-28.1	4	Protein that regulates the nuclear localization of ribonucleotide reductase Rnr2p and Rnr4p subunits; phosphorylated by Dun1p in response to DNA damage and degraded; N-terminal half has similarity to S. pombe Spd1 protein [Source:SGD;Acc:S000004429]
L	YLR437C-A	YLR437C-A	1	-1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CAR2/YLR438W [Source:SGD;Acc:S000028684]
L	YLR438C-A	LSM3	654	-347	4	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA [Source:SGD;Acc:S000006434]
L	YLR438W	CAR2	2257	-881.6	4	L-ornithine transaminase (OTAse), catalyzes the second step of arginine degradation, expression is dually-regulated by allophanate induction and a specific arginine induction process; not nitrogen catabolite repression sensitive [Source:SGD;Acc:S000004430]
L	YLR439W	MRPL4	535	-175.9	4	Mitochondrial ribosomal protein of the large subunit, homolog of prokaryotic L29 ribosomal protein; located at the ribosomal tunnel exit [Source:SGD;Acc:S000004431]
L	YLR440C	SEC39	320	-281.8	4	Component of the Dsl1p tethering complex that interacts with ER SNAREs Sec20p and Use1p; proposed to be involved in protein secretion; localizes to the ER and nuclear envelope [Source:SGD;Acc:S000004432]
L	YLR441C	RPS1A	4742	-1405.9	4	Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Bp and has similarity to rat S3a ribosomal protein [Source:SGD;Acc:S000004433]
L	YLR442C	SIR3	503	-361.5	4	Silencing protein that interacts with Sir2p and Sir4p, and histone H3 and H4 tails, to establish a transcriptionally silent chromatin state; required for spreading of silenced chromatin; recruited to chromatin through interaction with Rap1p [Source:SGD;Acc:S000004434]
L	YLR443W	ECM7	51	-35.1	4	Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency [Source:SGD;Acc:S000004435]
L	YLR444C	YLR444C	2	-2.4	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004436]
L	YLR445W	GMC2	11	-4.7	2	Putative protein of unknown function; transcription is regulated by Ume6p and induced in response to alpha factor [Source:SGD;Acc:S000004437]
L	YLR446W	YLR446W	27	-45.5	4	Putative protein of unknown function with similarity to hexokinases; transcript is upregulated during sporulation and the unfolded protein response; YLR446W is not an essential gene [Source:SGD;Acc:S000004438]
L	YLR447C	VMA6	1977	-417.9	4	Subunit d of the five-subunit V0 integral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found in the endomembrane system; stabilizes VO subunits; required for V1 domain assembly on the vacuolar membrane [Source:SGD;Acc:S000004439]
L	YLR448W	RPL6B	4192	-513.5	4	Protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Ap and to rat L6 ribosomal protein; binds to 5.8S rRNA [Source:SGD;Acc:S000004440]
L	YLR449W	FPR4	2181	-299.2	4	Peptidyl-prolyl cis-trans isomerase (PPIase) (proline isomerase) localized to the nucleus; catalyzes isomerization of proline residues in histones H3 and H4, which affects lysine methylation of those histones [Source:SGD;Acc:S000004441]
L	YLR450W	HMG2	1141	-437.6	4	One of two isozymes of HMG-CoA reductase that convert HMG-CoA to mevalonate, a rate-limiting step in sterol biosynthesis; overproduction induces assembly of peripheral ER membrane arrays and short nuclear-associated membrane stacks [Source:SGD;Acc:S000004442]
L	YLR451W	LEU3	135	-243	4	Zinc-finger transcription factor that regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; positively regulated by alpha-isopropylmalate, an intermediate in leucine biosynthesis [Source:SGD;Acc:S000004443]
L	YLR452C	SST2	720	-192	4	GTPase-activating protein for Gpa1p, regulates desensitization to alpha factor pheromone; also required to prevent receptor-independent signaling of the mating pathway; member of the RGS (regulator of G-protein signaling) family [Source:SGD;Acc:S000004444]
L	YLR453C	RIF2	26	-38.8	2	Protein that binds to the Rap1p C-terminus and acts synergistically with Rif1p to help control telomere length and establish telomeric silencing; deletion results in telomere elongation [Source:SGD;Acc:S000004445]
L	YLR454W	FMP27	517	-775.4	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004446]
L	YLR455W	PDP3	328	-190	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) [Source:SGD;Acc:S000004447]
L	YLR456W	YLR456W	26	-22.6	4	Putative protein of unknown function; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 [Source:SGD;Acc:S000004448]
L	YLR457C	NBP1	81	-84.1	4	Spindle pole body (SPB) component, required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex [Source:SGD;Acc:S000004449]
L	YLR458W	YLR458W	2	-10.9	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential NBP1 gene required for mitosis [Source:SGD;Acc:S000004450]
L	YLR459W	GAB1	118	-40.8	4	GPI transamidase subunit, involved in attachment of glycosylphosphatidylinositol (GPI) anchors to proteins; may have a role in recognition of the attachment signal or of the lipid portion of GPI [Source:SGD;Acc:S000004451]
L	YLR460C	YLR460C	393	-208.8	4	Member of the quinone oxidoreductase family, up-regulated in response to the fungicide mancozeb; possibly up-regulated by iodine [Source:SGD;Acc:S000004452]
L	YLR461W	PAU4	1	-0.1	1	Member of the seripauperin multigene family encoded mainly in subtelomeric regions; active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme [Source:SGD;Acc:S000004453]
L	YLR462W	YLR462W	138	-67.3	4	Putative protein of unknown function with similarity to helicases; YLR462W is within the telomere on the right arm of chromosome XII [Source:SGD;Acc:S000004454]
L	YLR463C	YLR463C	9	-2.7	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the uncharacterized ORFs YLR462W and YLR464W [Source:SGD;Acc:S000004455]
L	YLR464W	YLR464W	69	-54.1	4	Putative protein of unknown function; intron is predicted but not detected experimentally; YLR464W overlaps the verified gene YRF1-4/YLR466W and two dubious ORFs YLR463C and YLR465C [Source:SGD;Acc:S000004456]
L	YLR465C	BSC3	2	-2.1	2	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 100% of YLR465C overlaps the uncharacterized ORF YLR464W and 86% of YLR465C overlaps the verified gene YRF1-4 [Source:SGD;Acc:S000004457]
L	YLR466C-A	YLR466C-A	1	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W [Source:SGD;Acc:S000028685]
L	YLR466C-B	YLR466C-B	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000028686]
L	YLR466W	YRF1-4	329	-410.4	4	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000004458]
L	YLR467C-A	YLR467C-A	1	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YRF1-4/YLR466W [Source:SGD;Acc:S000028687]
L	YLR467W	YRF1-5	432	-490.2	4	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000004459]
M	YML001W	YPT7	1857	-430.9	4	Rab family GTPase; GTP-binding protein of the rab family; required for homotypic fusion event in vacuole inheritance, for endosome-endosome fusion, similar to mammalian Rab7 [Source:SGD;Acc:S000004460]
M	YML002W	YML002W	19	-11.2	2	Putative protein of unknown function; expression induced by heat and by calcium shortage [Source:SGD;Acc:S000004461]
M	YML003W	YML003W	17	-3	2	Putative protein of unknown function [Source:SGD;Acc:S000004462]
M	YML004C	GLO1	1161	-263.5	4	Monomeric glyoxalase I, catalyzes the detoxification of methylglyoxal (a by-product of glycolysis) via condensation with glutathione to produce S-D-lactoylglutathione; expression regulated by methylglyoxal levels and osmotic stress [Source:SGD;Acc:S000004463]
M	YML005W	TRM12	206	-202.5	4	S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; required for wybutosine formation in phenylalanine-accepting tRNA [Source:SGD;Acc:S000004464]
M	YML006C	GIS4	411	-119.4	4	CAAX box containing protein of unknown function, proposed to be involved in the RAS/cAMP signaling pathway [Source:SGD;Acc:S000004465]
M	YML007C-A	YML007C-A	0	nf	1	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria [Source:SGD;Acc:S000007621]
M	YML007W	YAP1	958	-361	4	Basic leucine zipper (bZIP) transcription factor required for oxidative stress tolerance; activated by H2O2 through the multistep formation of disulfide bonds and transit from the cytoplasm to the nucleus; mediates resistance to cadmium [Source:SGD;Acc:S000004466]
M	YML008C	ERG6	3056	-553.5	4	Delta(24)-sterol C-methyltransferase, converts zymosterol to fecosterol in the ergosterol biosynthetic pathway by methylating position C-24; localized to both lipid particles and mitochondrial outer membrane [Source:SGD;Acc:S000004467]
M	YML009C	MRPL39	188	-36.9	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000004468]
M	YML009C-A	YML009C-A	2	-2	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004469]
M	YML009W-B	YML009W-B	12	-2.3	2	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion mutation confers an increase in Ty1 transposition [Source:SGD;Acc:S000004471]
M	YML010W	SPT5	2630	-716.1	4	Protein involved in regulating Pol I and Pol II transcription and pre-mRNA processing; forms a complex with Spt4p; contains a C-terminal repeat domain that is a target for phosphorylation by Sgv1p [Source:SGD;Acc:S000004470]
M	YML011C	RAD33	114	-93.9	4	Protein involved in nucleotide excision repair; green fluorescent protein (GFP)-fusion protein localizes to the nucleus [Source:SGD;Acc:S000004472]
M	YML012C-A	YML012C-A	4	-2.8	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SEL1 [Source:SGD;Acc:S000004474]
M	YML012W	ERV25	1168	-301.3	4	Protein that forms a heterotrimeric complex with Erp1, Erp2p, and Emp24, member of the p24 family involved in endoplasmic reticulum to Golgi transport [Source:SGD;Acc:S000004473]
M	YML013W	UBX2	500	-247.4	4	Protein involved in ER-associated protein degradation; proposed to coordinate the assembly of proteins involved in ERAD; contains a UBX (ubiquitin regulatory X) domain and a ubiquitin-associated (UBA) domain [Source:SGD;Acc:S000004475]
M	YML014W	TRM9	516	-171.8	4	tRNA methyltransferase, catalyzes esterification of modified uridine nucleotides in tRNA(Arg3) and tRNA(Glu), likely as part of a complex with Trm112p; deletion confers resistance to zymocin [Source:SGD;Acc:S000004476]
M	YML015C	TAF11	280	-658	4	TFIID subunit (40 kDa), involved in RNA polymerase II transcription initiation, similar to histone H3 with atypical histone fold motif of Spt3-like transcription factors [Source:SGD;Acc:S000004477]
M	YML016C	PPZ1	1530	-1228.4	4	Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance [Source:SGD;Acc:S000004478]
M	YML017W	PSP2	1551	-560.5	4	Asn rich cytoplasmic protein that contains RGG motifs; high-copy suppressor of group II intron-splicing defects of a mutation in MRS2 and of a conditional mutation in POL1 (DNA polymerase alpha); possible role in mitochondrial mRNA splicing [Source:SGD;Acc:S000004479]
M	YML018C	YML018C	58	-42.5	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; physical interaction with Atg27p suggests a possible role in autophagy; YML018C is not an essential gene [Source:SGD;Acc:S000004480]
M	YML019W	OST6	231	-130.7	4	Subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; similar to and partially functionally redundant with Ost3p [Source:SGD;Acc:S000004481]
M	YML020W	YML020W	253	-219.2	4	Putative protein of unknown function [Source:SGD;Acc:S000004482]
M	YML021C	UNG1	279	-140	4	Uracil-DNA glycosylase, required for repair of uracil in DNA formed by spontaneous cytosine deamination, not required for strand-specific mismatch repair, cell-cycle regulated, expressed in late G1, localizes to mitochondria and nucleus [Source:SGD;Acc:S000004483]
M	YML022W	APT1	1749	-314.5	4	Adenine phosphoribosyltransferase, catalyzes the formation of AMP from adenine and 5-phosphoribosylpyrophosphate; involved in the salvage pathway of purine nucleotide biosynthesis [Source:SGD;Acc:S000004484]
M	YML023C	NSE5	60	-93.5	4	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair [Source:SGD;Acc:S000004485]
M	YML024W	RPS17A	4627	-638.4	4	Ribosomal protein 51 (rp51) of the small (40s) subunit; nearly identical to Rps17Bp and has similarity to rat S17 ribosomal protein [Source:SGD;Acc:S000004486]
M	YML025C	YML6	518	-171.4	4	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins [Source:SGD;Acc:S000004487]
M	YML026C	RPS18B	5038	-513.7	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps18Ap and has similarity to E. coli S13 and rat S18 ribosomal proteins [Source:SGD;Acc:S000004488]
M	YML027W	YOX1	117	-37.3	4	Homeodomain-containing transcriptional repressor, binds to Mcm1p and to early cell cycle boxes (ECBs) in the promoters of cell cycle-regulated genes expressed in M/G1 phase; expression is cell cycle-regulated; potential Cdc28p substrate [Source:SGD;Acc:S000004489]
M	YML028W	TSA1	4307	-1133.2	4	Thioredoxin peroxidase, acts as both a ribosome-associated and free cytoplasmic antioxidant; self-associates to form a high-molecular weight chaperone complex under oxidative stress; deletion results in mutator phenotype [Source:SGD;Acc:S000004490]
M	YML029W	USA1	525	-404.5	4	Scaffold subunit of the Hrd1p ubiquitin ligase that also promotes ligase oligomerization; involved in ER-associated protein degradation (ERAD); interacts with the U1 snRNP-specific protein, Snp1p [Source:SGD;Acc:S000004491]
M	YML030W	RCF1	224	-140	4	Putative protein of unknown function; GFP-fusion protein localizes to mitochondria; may interact with respiratory chain complexes III or IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000004492]
M	YML031C-A	YML031C-A	1	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF NDC1/YML031W; questionable ORF from MIPS [Source:SGD;Acc:S000028809]
M	YML031W	NDC1	818	-465.3	4	Nuclear envelope protein with multiple putative transmembrane domains, required for nuclear pore complex assembly and spindle pole body duplication; required for meiosis II [Source:SGD;Acc:S000004493]
M	YML032C	RAD52	395	-266.8	4	Protein that stimulates strand exchange by facilitating Rad51p binding to single-stranded DNA; anneals complementary single-stranded DNA; involved in the repair of double-strand breaks in DNA during vegetative growth and meiosis [Source:SGD;Acc:S000004494]
M	YML034C-A	YML034C-A	10	-2	2	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004499]
M	YML034W	SRC1	798	-428.8	4	Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted b  p; mutant has aneuploidy tolerance [Source:SGD;Acc:S000004497]
M	YML035C	AMD1	1418	-788.6	4	AMP deaminase, tetrameric enzyme that catalyzes the deamination of AMP to form IMP and ammonia; may be involved in regulation of intracellular adenine nucleotide pools [Source:SGD;Acc:S000004498]
M	YML036W	CGI121	656	-155.1	4	Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification [Source:SGD;Acc:S000004500]
M	YML037C	YML037C	81	-62.4	4	Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene [Source:SGD;Acc:S000004501]
M	YML038C	YMD8	75	-27.5	4	Putative nucleotide sugar transporter, has similarity to Vrg4p [Source:SGD;Acc:S000004502]
M	YML039W	YML039W	4995	-2518.7	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000004503]
M	YML040W	YML040W	4675	-1737.6	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000004504]
M	YML041C	VPS71	92	-1096.2	4	Nucleosome-binding component of the SWR1 complex, which exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; required for vacuolar protein sorting [Source:SGD;Acc:S000004505]
M	YML042W	CAT2	480	-814.1	4	Carnitine acetyl-CoA transferase present in both mitochondria and peroxisomes, transfers activated acetyl groups to carnitine to form acetylcarnitine which can be shuttled across membranes [Source:SGD;Acc:S000004506]
M	YML043C	RRN11	21	-17.7	2	Component of the core factor (CF) rDNA transcription factor complex; CF is required for transcription of 35S rRNA genes by RNA polymerase I and is composed of Rrn6p, Rrn7p, and Rrn11p [Source:SGD;Acc:S000004507]
M	YML045W	YML045W	4920	-2179.8	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000004508]
M	YML045W-A	YML045W-A	4555	-1444	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007381]
M	YML046W	PRP39	234	-618.8	4	U1 snRNP protein involved in splicing, contains multiple tetriatricopeptide repeats [Source:SGD;Acc:S000004509]
M	YML047C	PRM6	12	-2	2	Pheromone-regulated protein, predicted to have 2 transmembrane segments; regulated by Ste12p during mating [Source:SGD;Acc:S000004510]
M	YML047W-A	YML047W-A	1	-1.2	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004512]
M	YML048W	GSF2	2106	-517.4	4	ER localized integral membrane protein that may promote secretion of certain hexose transporters, including Gal2p; involved in glucose-dependent repression [Source:SGD;Acc:S000004511]
M	YML049C	RSE1	616	-575.4	4	Protein involved in pre-mRNA splicing; component of the pre-spliceosome; associates with U2 snRNA; involved in ER to Golgi transport [Source:SGD;Acc:S000004513]
M	YML050W	AIM32	195	-124.7	4	Putative protein of unknown function; null mutant is viable and displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000004514]
M	YML051W	GAL80	116	-230.9	4	Transcriptional regulator involved in the repression of GAL genes in the absence of galactose; inhibits transcriptional activation by Gal4p; inhibition relieved by Gal3p or Gal1p binding [Source:SGD;Acc:S000004515]
M	YML052W	SUR7	1042	-298.8	4	Plasma membrane protein that localizes to furrow-like invaginations (MCC patches); component of eisosomes; associated with endocytosis, along with Pil1p and Lsp1p; sporulation and plasma membrane sphingolipid content are altered in mutants [Source:SGD;Acc:S000004516]
M	YML053C	YML053C	4	-8	2	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus; overexpression causes a cell cycle delay or arrest; YML053C is not an essential gene [Source:SGD;Acc:S000004517]
M	YML054C	CYB2	664	-1735.2	4	Cytochrome b2 (L-lactate cytochrome-c oxidoreductase), component of the mitochondrial intermembrane space, required for lactate utilization; expression is repressed by glucose and anaerobic conditions [Source:SGD;Acc:S000004518]
M	YML054C-A	YML054C-A	6	-2.4	2	Putative protein of unknown function [Source:SGD;Acc:S000028573]
M	YML055W	SPC2	548	-142.2	4	Subunit of signal peptidase complex (Spc1p, Spc2p, Spc3p, Sec11p), which catalyzes cleavage of N-terminal signal sequences of proteins targeted to the secretory pathway; homologous to mammalian SPC25 [Source:SGD;Acc:S000004519]
M	YML056C	IMD4	3488	-1350.8	4	Inosine monophosphate dehydrogenase, catalyzes the first step of GMP biosynthesis, member of a four-gene family in S. cerevisiae, constitutively expressed [Source:SGD;Acc:S000004520]
M	YML057C-A	YML057C-A	9	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene CMP2/YML057W [Source:SGD;Acc:S000004522]
M	YML057W	CMP2	1296	-1525.8	4	Calcineurin A; one isoform (the other is CNA1) of the catalytic subunit of calcineurin, a Ca++/calmodulin-regulated protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is CNB1 [Source:SGD;Acc:S000004521]
M	YML058W	SML1	668	-109.6	4	Ribonucleotide reductase inhibitor involved in regulating dNTP production; regulated by Mec1p and Rad53p during DNA damage and S phase [Source:SGD;Acc:S000004523]
M	YML058W-A	HUG1	26	-102.4	4	Protein involved in the Mec1p-mediated checkpoint pathway that responds to DNA damage or replication arrest, transcription is induced by DNA damage [Source:SGD;Acc:S000007472]
M	YML059C	NTE1	758	-736.6	4	Serine esterase, homolog of human neuropathy target esterase (NTE); Nte1p-mediated phosphatidylcholine turnover influences transcription factor Opi1p localization, affecting transcriptional regulation of phospholipid biosynthesis genes [Source:SGD;Acc:S000004524]
M	YML060W	OGG1	90	-47.9	4	Mitochondrial glycosylase/lyase that specifically excises 7,8-dihydro-8-oxoguanine residues located opposite cytosine or thymine residues in DNA, repairs oxidative damage to mitochondrial DNA, contributes to UVA resistance [Source:SGD;Acc:S000004525]
M	YML061C	PIF1	312	-159.6	4	DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis [Source:SGD;Acc:S000004526]
M	YML062C	MFT1	622	-194.3	4	Subunit of the THO complex, which is a nuclear complex comprised of Hpr1p, Mft1p, Rlr1p, and Thp2p, that is involved in transcription elongation and mitotic recombination; involved in telomere maintenance [Source:SGD;Acc:S000004527]
M	YML063W	RPS1B	4807	-1433.5	4	Ribosomal protein 10 (rp10) of the small (40S) subunit; nearly identical to Rps1Ap and has similarity to rat S3a ribosomal protein [Source:SGD;Acc:S000004528]
M	YML064C	TEM1	204	-182.6	4	GTP-binding protein of the ras superfamily involved in termination of M-phase; controls actomyosin and septin dynamics during cytokinesis [Source:SGD;Acc:S000004529]
M	YML065W	ORC1	496	-345.7	4	Largest subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing; exhibits ATPase activity [Source:SGD;Acc:S000004530]
M	YML066C	SMA2	12	-4.6	2	Meiosis-specific prospore membrane protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation [Source:SGD;Acc:S000004531]
M	YML067C	ERV41	488	-159.5	4	Protein localized to COPII-coated vesicles, forms a complex with Erv46p; involved in the membrane fusion stage of transport; has homology to human ERGIC2 (PTX1) protein [Source:SGD;Acc:S000004532]
M	YML068W	ITT1	35	-54.7	3	Protein that modulates the efficiency of translation termination, interacts with translation release factors eRF1 (Sup45p) and eRF3 (Sup35p) in vitro, contains a zinc finger domain characteristic of the TRIAD class of proteins [Source:SGD;Acc:S000004533]
M	YML069W	POB3	1851	-446.3	4	Subunit of the heterodimeric FACT complex (Spt16p-Pob3p), which associates with chromatin via interaction with Nhp6Ap and Nhp6Bp, and reorganizes nucleosomes to facilitate access to DNA by RNA and DNA polymerases [Source:SGD;Acc:S000004534]
M	YML070W	DAK1	2637	-1979.4	4	Dihydroxyacetone kinase, required for detoxification of dihydroxyacetone (DHA); involved in stress adaptation [Source:SGD;Acc:S000004535]
M	YML071C	COG8	628	-366.5	4	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000004536]
M	YML072C	TCB3	2795	-2447.5	4	Lipid-binding protein, localized to the bud via specific mRNA transport; non-tagged protein detected in a phosphorylated state in mitochondria; GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact [Source:SGD;Acc:S000004537]
M	YML073C	RPL6A	4248	-478.4	4	N-terminally acetylated protein component of the large (60S) ribosomal subunit, has similarity to Rpl6Bp and to rat L6 ribosomal protein; binds to 5.8S rRNA [Source:SGD;Acc:S000004538]
M	YML074C	FPR3	2497	-437	4	Nucleolar peptidyl-prolyl cis-trans isomerase (PPIase); FK506 binding protein; phosphorylated by casein kinase II (Cka1p-Cka2p-Ckb1p-Ckb2p) and dephosphorylated by Ptp1p [Source:SGD;Acc:S000004539]
M	YML075C	HMG1	1368	-635.5	4	One of two isozymes of HMG-CoA reductase that catalyzes the conversion of HMG-CoA to mevalonate, which is a rate-limiting step in sterol biosynthesis; localizes to the nuclear envelope; overproduction induces the formation of karmellae [Source:SGD;Acc:S000004540]
M	YML076C	WAR1	256	-232.8	4	Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively [Source:SGD;Acc:S000004541]
M	YML077W	BET5	105	-56.7	4	Component of the TRAPP (transport protein particle) complex, which plays an essential role in the vesicular transport from endoplasmic reticulum to Golgi [Source:SGD;Acc:S000004542]
M	YML078W	CPR3	2149	-345.7	4	Mitochondrial peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; involved in protein refolding after import into mitochondria [Source:SGD;Acc:S000004543]
M	YML079W	YML079W	944	-274.3	4	Non-essential protein of unknown function with structural resemblance to plant storage and ligand binding proteins (canavalin, glycinin, auxin binding protein) and to some enzymes (epimerase, germin); localizes to the nucleus and cytoplasm [Source:SGD;Acc:S000004544]
M	YML080W	DUS1	420	-222.5	4	Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus3p, and Dus4p; modifies pre-tRNA(Phe) at U17 [Source:SGD;Acc:S000004545]
M	YML081C-A	ATP18	229	-59.9	4	Subunit of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; termed subunit I or subunit j; does not correspond to known ATP synthase subunits in other organisms [Source:SGD;Acc:S000007247]
M	YML081W	TDA9	304	-216.5	4	DNA-binding protein, putative transcription factor; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene [Source:SGD;Acc:S000004546]
M	YML082W	YML082W	268	-306.2	4	Putative protein predicted to have carbon-sulfur lyase activity; transcriptionally regulated by Upc2p via an upstream sterol response element; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and the cytoplasm; YML082W is not   ential gene [Source:SGD;Acc:S000004547]
M	YML083C	YML083C	14	-18.6	2	Putative protein of unknown function; transcriptionally regulated by Upc2p via an upstream sterol response element; strong increase in transcript abundance during anaerobic growth compared to aerobic growth; cells deleted for YML083C do not exhibit    defects in anerobic or anaerobic conditions [Source:SGD;Acc:S000004548]
M	YML084W	YML084W	2	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004549]
M	YML085C	TUB1	2780	-750	4	Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules [Source:SGD;Acc:S000004550]
M	YML086C	ALO1	2022	-554.3	4	D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress [Source:SGD;Acc:S000004551]
M	YML087C	AIM33	10	-33.3	2	Putative protein of unknown function, highly conserved across species and orthologous to human CYB5R4; null mutant displays reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000004552]
M	YML088W	UFO1	171	-130.2	4	F-box receptor protein, subunit of the Skp1-Cdc53-F-box receptor (SCF) E3 ubiquitin ligase complex; binds to phosphorylated Ho endonuclease, allowing its ubiquitylation by SCF and subsequent degradation [Source:SGD;Acc:S000004553]
M	YML089C	YML089C	3	-1.3	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression induced by calcium shortage [Source:SGD;Acc:S000004554]
M	YML090W	YML090W	1	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YML089C; exhibits growth defect on a non-fermentable (respiratory) carbon source [Source:SGD;Acc:S000004555]
M	YML091C	RPM2	317	-298.6	4	Protein subunit of mitochondrial RNase P, has roles in nuclear transcription, cytoplasmic and mitochondrial RNA processing, and mitochondrial translation; distributed to mitochondria, cytoplasmic processing bodies, and the nucleus [Source:SGD;Acc:S000004556]
M	YML092C	PRE8	1966	-272.5	4	Alpha 2 subunit of the 20S proteasome [Source:SGD;Acc:S000004557]
M	YML093W	UTP14	1480	-472.2	4	Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit [Source:SGD;Acc:S000004558]
M	YML094C-A	YML094C-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene GIM5/YML094W; deletion confers sensitivity to GSAO [Source:SGD;Acc:S000004561]
M	YML094W	GIM5	1066	-121.9	4	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it [Source:SGD;Acc:S000004559]
M	YML095C	RAD10	91	-68	4	Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein [Source:SGD;Acc:S000004560]
M	YML096W	YML096W	217	-225.3	4	Putative protein of unknown function with similarity to asparagine synthetases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YML096W is not an essential gene and partially overlaps the verified gene RAD10 [Source:SGD;Acc:S000004562]
M	YML097C	VPS9	493	-268.6	4	A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin [Source:SGD;Acc:S000004563]
M	YML098W	TAF13	91	-151	4	TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors [Source:SGD;Acc:S000004564]
M	YML099C	ARG81	68	-154	4	Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p [Source:SGD;Acc:S000004565]
M	YML099W-A	YML099W-A	5	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF ARG81/YML099C [Source:SGD;Acc:S000004567]
M	YML100W	TSL1	2367	-1270.2	4	Large subunit of trehalose 6-phosphate synthase (Tps1p)/phosphatase (Tps2p) complex, which converts uridine-5'-diphosphoglucose and glucose 6-phosphate to trehalose, similar to Tps3p and may share function; mutant has aneuploidy tolerance [Source:SGD;Acc:S000004566]
M	YML100W-A	YML100W-A	0	nf	1	Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028688]
M	YML101C	CUE4	482	-119.8	4	Protein of unknown function; has a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination [Source:SGD;Acc:S000004568]
M	YML101C-A	YML101C-A	5	-2.2	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004569]
M	YML102W	CAC2	281	-187.3	4	Subunit of chromatin assembly factor I (CAF-1), with Rlf2p and Msi1p; chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of  NA damage checkpoint after DNA repair; and chromatin dynamics during transcription [Source:SGD;Acc:S000004570]
M	YML103C	NUP188	1104	-1390	4	Subunit of the nuclear pore complex (NPC), involved in the structural organization of the complex and of the nuclear envelope, also involved in nuclear envelope permeability, interacts with Pom152p and Nic96p [Source:SGD;Acc:S000004571]
M	YML104C	MDM1	72	-174.5	4	Intermediate filament protein, required for nuclear and mitochondrial transmission to daughter buds; contains a Phox homology (PX) domain and specifically binds phosphatidylinositol 3-phosphate (PtdIns-3-P) [Source:SGD;Acc:S000004572]
M	YML105C	SEC65	1226	-168.1	4	Subunit of the signal recognition particle (SRP), involved in protein targeting to the ER; interacts with Srp54p; homolog of mammalian SRP19 [Source:SGD;Acc:S000004573]
M	YML106W	URA5	2071	-518.3	4	Major orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; minor OPRTase encoded by URA10 [Source:SGD;Acc:S000004574]
M	YML107C	PML39	118	-143.3	4	Protein required for nuclear retention of unspliced pre-mRNAs along with Mlp1p and Pml1p; anchored to nuclear pore complex via Mlp1p and Mlp2p; found with the subset of nuclear pores farthest from the nucleolus; may interact with ribosomes [Source:SGD;Acc:S000004575]
M	YML108W	YML108W	86	-65.4	4	Putative protein of unknown function whose structure defines a new subfamily of the split beta-alpha-beta sandwiches; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YML108W is not an essential gene [Source:SGD;Acc:S000004576]
M	YML109W	ZDS2	314	-198.5	4	Protein with a role in regulating Swe1p-dependent polarized growth; interacts with Cdc55p; interacts with silencing proteins at the telomere; implicated in the mitotic exit network through regulation of Cdc14p localization; paralog of Zds1p [Source:SGD;Acc:S000004577]
M	YML110C	COQ5	975	-224.9	4	2-hexaprenyl-6-methoxy-1,4-benzoquinone methyltransferase, involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes [Source:SGD;Acc:S000004578]
M	YML111W	BUL2	537	-2350.4	4	Component of the Rsp5p E3-ubiquitin ligase complex, involved in intracellular amino acid permease sorting, functions in heat shock element mediated gene expression, essential for growth in stress conditions, functional homolog of BUL1 [Source:SGD;Acc:S000004579]
M	YML112W	CTK3	375	-826.6	4	Gamma subunit of C-terminal domain kinase I (CTDK-I), which phosphorylates both RNA pol II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and ribosomal protein Rps2p to increase translational fidelity [Source:SGD;Acc:S000004580]
M	YML113W	DAT1	86	-24	4	DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability [Source:SGD;Acc:S000004581]
M	YML114C	TAF8	208	-149.5	4	TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation [Source:SGD;Acc:S000004582]
M	YML115C	VAN1	690	-272	4	Component of the mannan polymerase I, which contains Van1p and Mnn9p and is involved in the first steps of mannan synthesis; mutants are vanadate-resistant [Source:SGD;Acc:S000004583]
M	YML116W	ATR1	52	-33.2	3	Multidrug efflux pump of the major facilitator superfamily, required for resistance to aminotriazole and 4-nitroquinoline-N-oxide [Source:SGD;Acc:S000004584]
M	YML116W-A	YML116W-A	2	-1.2	1	Putative protein of unknown function [Source:SGD;Acc:S000004586]
M	YML117W	NAB6	1132	-462.6	4	Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP [Source:SGD;Acc:S000004585]
M	YML118W	NGL3	98	-119.6	4	3'-5' exonuclease specific for poly-A RNAs; has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; similar to Ngl1p and Ngl2p [Source:SGD;Acc:S000004587]
M	YML119W	YML119W	270	-132.2	4	Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate [Source:SGD;Acc:S000004588]
M	YML120C	NDI1	1316	-1145.4	4	NADH:ubiquinone oxidoreductase, transfers electrons from NADH to ubiquinone in the respiratory chain but does not pump protons, in contrast to the higher eukaryotic multisubunit respiratory complex I; phosphorylated; homolog of human AMID [Source:SGD;Acc:S000004589]
M	YML121W	GTR1	219	-166.6	4	Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB [Source:SGD;Acc:S000004590]
M	YML122C	YML122C	3	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004591]
M	YML123C	PHO84	1584	-379.3	4	High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p [Source:SGD;Acc:S000004592]
M	YML124C	TUB3	2416	-574.5	4	Alpha-tubulin; associates with beta-tubulin (Tub2p) to form tubulin dimer, which polymerizes to form microtubules; expressed at lower level than Tub1p [Source:SGD;Acc:S000004593]
M	YML125C	PGA3	1526	-301.2	4	Putative cytochrome b5 reductase, localized to the plasma membrane; may be involved in regulation of lifespan; required for maturation of Gas1p and Pho8p, proposed to be involved in protein trafficking [Source:SGD;Acc:S000004594]
M	YML126C	ERG13	2754	-1432.4	4	3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase, catalyzes the formation of HMG-CoA from acetyl-CoA and acetoacetyl-CoA; involved in the second step in mevalonate biosynthesis [Source:SGD;Acc:S000004595]
M	YML127W	RSC9	918	-281.4	4	Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway [Source:SGD;Acc:S000004596]
M	YML128C	MSC1	1432	-832.4	4	Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria and is phosphorylated [Source:SGD;Acc:S000004597]
M	YML129C	COX14	316	-59.8	4	Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes [Source:SGD;Acc:S000004598]
M	YML130C	ERO1	1057	-483.8	4	Thiol oxidase required for oxidative protein folding in the endoplasmic reticulum [Source:SGD;Acc:S000004599]
M	YML131W	YML131W	659	-311	4	Putative protein of unknown function with similarity to medium chain dehydrogenase/reductases; expression induced by stresses including osmotic shock, DNA damaging agents, and other chemicals; GFP-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000004600]
M	YML132W	COS3	226	-76.9	4	Protein involved in salt resistance; interacts with sodium:hydrogen antiporter Nha1p; member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000004601]
M	YML133C	YML133C	391	-336.2	4	Putative protein of unknown function with similarity to helicases; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YML133C contains an intron [Source:SGD;Acc:S000004602]
M	YML133W-A	YML133W-A	14	-25.7	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C [Source:SGD;Acc:S000028689]
M	YML133W-B	YML133W-B	43	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the uncharacterized ORF YML133C [Source:SGD;Acc:S000028690]
M	YMR001C	CDC5	326	-335.3	4	Polo-like kinase with multiple functions in mitosis and cytokinesis through substrate phosphorylation, also functions in adaptation to DNA damage during meiosis; has similarity to Xenopus Plx1 and S. pombe Plo1p; possible Cdc28p substrate [Source:SGD;Acc:S000004603]
M	YMR001C-A	YMR001C-A	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000028691]
M	YMR002W	MIX17	568	-332.2	4	Mitochondrial intermembrane space protein, required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs [Source:SGD;Acc:S000004604]
M	YMR003W	AIM34	63	-25.6	4	Protein of unknown function; GFP-fusion protein localizes to the mitochondria; null mutant is viable and displays reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000004605]
M	YMR004W	MVP1	683	-493.1	4	Protein required for sorting proteins to the vacuole; overproduction of Mvp1p suppresses several dominant VPS1 mutations; Mvp1p and Vps1p act in concert to promote membrane traffic to the vacuole; participates in transcription initiation and/or earl  gation of specific genes; interacts with foot domain of RNA polymerase II; deletion results in abnormal CTD-Ser5 phosphorylation of RNA polymerase II at specific promoter regions [Source:SGD;Acc:S000004606]
M	YMR005W	TAF4	712	-1081.5	4	TFIID subunit (48 kDa), involved in RNA polymerase II transcription initiation; potential Cdc28p substrate [Source:SGD;Acc:S000004607]
M	YMR006C	PLB2	341	-189.1	4	Phospholipase B (lysophospholipase) involved in phospholipid metabolism; displays transacylase activity in vitro; overproduction confers resistance to lysophosphatidylcholine [Source:SGD;Acc:S000004608]
M	YMR007W	YMR007W	4	-2.7	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004609]
M	YMR008C	PLB1	720	-318.2	4	Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol [Source:SGD;Acc:S000004610]
M	YMR009W	ADI1	580	-188.3	4	Acireductone dioxygenease involved in the methionine salvage pathway; ortholog of human MTCBP-1; transcribed with YMR010W and regulated post-transcriptionally by RNase III (Rnt1p) cleavage; ADI1 mRNA is induced in heat shock conditions [Source:SGD;Acc:S000004611]
M	YMR010W	YMR010W	219	-62.5	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR010W is not an essential gene; YMR010W mRNA is transcribed with ADI1 [Source:SGD;Acc:S000004612]
M	YMR011W	HXT2	1406	-151.8	4	High-affinity glucose transporter of the major facilitator superfamily, expression is induced by low levels of glucose and repressed by high levels of glucose [Source:SGD;Acc:S000004613]
M	YMR012W	CLU1	3304	-2100.4	4	eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant [Source:SGD;Acc:S000004614]
M	YMR013C	SEC59	71	-34.8	4	Dolichol kinase, catalyzes the terminal step in dolichyl monophosphate (Dol-P) biosynthesis; required for viability and for normal rates of lipid intermediate synthesis and protein N-glycosylation [Source:SGD;Acc:S000004615]
M	YMR013C-A	YMR013C-A	1	-2.6	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF SEC59/YML013C [Source:SGD;Acc:S000028847]
M	YMR013W-A	YMR013W-A	2	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the characterized snoRNA gene snR73 [Source:SGD;Acc:S000007622]
M	YMR014W	BUD22	659	-145.9	4	Protein required for 18S rRNA maturation and small ribosomal subunit biogenesis; cosediments with pre-ribosomal particles; mutation decreases efficiency of +1 Ty1 frameshifting and transposition, and affects budding pattern [Source:SGD;Acc:S000004616]
M	YMR015C	ERG5	1063	-457.4	4	C-22 sterol desaturase, a cytochrome P450 enzyme that catalyzes the formation of the C-22(23) double bond in the sterol side chain in ergosterol biosynthesis; may be a target of azole antifungal drugs [Source:SGD;Acc:S000004617]
M	YMR016C	SOK2	677	-169.1	4	Nuclear protein that plays a regulatory role in the cyclic AMP (cAMP)-dependent protein kinase (PKA) signal transduction pathway; negatively regulates pseudohyphal differentiation; homologous to several transcription factors [Source:SGD;Acc:S000004618]
M	YMR017W	SPO20	14	-15.4	2	Meiosis-specific subunit of the t-SNARE complex, required for prospore membrane formation during sporulation; similar to but not functionally redundant with Sec9p; SNAP-25 homolog [Source:SGD;Acc:S000004619]
M	YMR018W	YMR018W	12	-11.4	2	Putative protein of unknown function with similarity to human PEX5Rp (peroxin protein 5 related protein); transcription increases during colony development similar to genes involved in peroxisome biogenesis; YMR018W is not an essential gene [Source:SGD;Acc:S000004620]
M	YMR019W	STB4	328	-81.1	4	Protein that binds Sin3p in a two-hybrid assay; contains a Zn(II)2Cys6 zinc finger domain characteristic of DNA-binding proteins; computational analysis suggests a role in regulation of expression of genes encoding transporters [Source:SGD;Acc:S000004621]
M	YMR020W	FMS1	309	-299.3	4	Polyamine oxidase, converts spermine to spermidine, which is required for the essential hypusination modification of translation factor eIF-5A; also involved in pantothenic acid biosynthesis [Source:SGD;Acc:S000004622]
M	YMR021C	MAC1	101	-56	4	Copper-sensing transcription factor involved in regulation of genes required for high affinity copper transport [Source:SGD;Acc:S000004623]
M	YMR022W	UBC7	300	-46.7	4	Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly [Source:SGD;Acc:S000004624]
M	YMR023C	MSS1	115	-148.3	4	Mitochondrial protein, forms a heterodimer complex with Mto1p that performs the 5-carboxymethylaminomethyl modification of the wobble uridine base in mitochondrial tRNAs; similar to human GTPBP3 [Source:SGD;Acc:S000004625]
M	YMR024W	MRPL3	801	-452	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000004626]
M	YMR025W	CSI1	28	-118.2	4	Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling [Source:SGD;Acc:S000004627]
M	YMR026C	PEX12	186	-269.4	4	C3HC4-type RING-finger peroxin and E3 ubiquitin ligase, required for peroxisome biogenesis and peroxisomal matrix protein import; forms translocation subcomplex with Pex2p and Pex10p; mutations in human homolog cause peroxisomal disorder [Source:SGD;Acc:S000004628]
M	YMR027W	YMR027W	1353	-472.1	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR027W is not an essential gene [Source:SGD;Acc:S000004629]
M	YMR028W	TAP42	330	-261.1	4	Essential protein involved in the TOR signaling pathway; physically associates with the protein phosphatase 2A and the SIT4 protein phosphatase catalytic subunits [Source:SGD;Acc:S000004630]
M	YMR029C	FAR8	720	-204.9	4	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p [Source:SGD;Acc:S000004631]
M	YMR030W	RSF1	104	-108.1	4	Protein required for respiratory growth; localized to both the nucleus and mitochondrion; may interact with transcription factors to mediate the transition to respiratory growth and activate transcription of nuclear and mitochondrial genes [Source:SGD;Acc:S000004632]
M	YMR030W-A	YMR030W-A	1	0	1	Putative protein of unknown function [Source:SGD;Acc:S000028574]
M	YMR031C	EIS1	2377	-1090.1	4	Component of the eisosome that is required for proper eisosome assembly; similarity to Ykl050cp and Uso1p; the authentic, non-tagged protein is detected in a phosphorylated state in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004633]
M	YMR031W-A	YMR031W-A	8	-3.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C [Source:SGD;Acc:S000004634]
M	YMR032W	HOF1	173	-71.2	4	Bud neck-localized, SH3 domain-containing protein required for cytokinesis; regulates actomyosin ring dynamics and septin localization; interacts with the formins, Bni1p and Bnr1p, and with Cyk3p, Vrp1p, and Bni5p [Source:SGD;Acc:S000004635]
M	YMR033W	ARP9	803	-320.9	4	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation [Source:SGD;Acc:S000004636]
M	YMR034C	YMR034C	17	-8.6	3	Putative transporter, member of the SLC10 carrier family; identified in a transposon mutagenesis screen as a gene involved in azole resistance; YMR034C is not an essential gene [Source:SGD;Acc:S000004637]
M	YMR035W	IMP2	21	-20.5	4	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p [Source:SGD;Acc:S000004638]
M	YMR036C	MIH1	153	-1181.2	4	Protein tyrosine phosphatase involved in cell cycle control; regulates the phosphorylation state of Cdc28p; homolog of S. pombe cdc25 [Source:SGD;Acc:S000004639]
M	YMR037C	MSN2	510	-175.9	4	Transcriptional activator related to Msn4p; activated in stress conditions, which results in translocation from the cytoplasm to the nucleus; binds DNA at stress response elements of responsive genes, inducing gene expression [Source:SGD;Acc:S000004640]
M	YMR038C	CCS1	1761	-229	4	Copper chaperone for superoxide dismutase Sod1p, involved in oxidative stress protection; Met-X-Cys-X2-Cys motif within the N-terminal portion is involved in insertion of copper into Sod1p under conditions of copper deprivation [Source:SGD;Acc:S000004641]
M	YMR039C	SUB1	1166	-271.4	4	Transcriptional coactivator, facilitates elongation through factors that modify RNAP II; role in peroxide resistance involving Rad2p; role in the hyperosmotic stress response through polymerase recruitment at RNAP II and RNAP III genes [Source:SGD;Acc:S000004642]
M	YMR040W	YET2	28	-57	4	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; homolog of human BAP31 protein [Source:SGD;Acc:S000004643]
M	YMR041C	ARA2	269	-170.3	4	NAD-dependent arabinose dehydrogenase, involved in biosynthesis of dehydro-D-arabinono-1,4-lactone; similar to plant L-galactose dehydrogenase [Source:SGD;Acc:S000004644]
M	YMR042W	ARG80	73	-39	4	Transcription factor involved in regulation of arginine-responsive genes; acts with Arg81p and Arg82p [Source:SGD;Acc:S000004645]
M	YMR043W	MCM1	512	-159.9	4	Transcription factor involved in cell-type-specific transcription and pheromone response; plays a central role in the formation of both repressor and activator complexes [Source:SGD;Acc:S000004646]
M	YMR044W	IOC4	429	-148.3	4	Member of a complex (Isw1b) with Isw1p and Ioc2p that exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing, contains a PWWP motif [Source:SGD;Acc:S000004647]
M	YMR045C	YMR045C	3909	-1468.1	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000004648]
M	YMR046C	YMR046C	3017	-591.3	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000004649]
M	YMR046W-A	YMR046W-A	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007248]
M	YMR047C	NUP116	1045	-983.6	4	Subunit of the Nup82 subcomplex of the nuclear pore complex; localized to both sides of the pore; contains a repetitive GLFG motif that interacts with mRNA export factor Mex67p and with karyopherin Kap95p; homologous to Nup100p [Source:SGD;Acc:S000004650]
M	YMR048W	CSM3	108	-98.3	4	Replication fork associated factor, required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis [Source:SGD;Acc:S000004651]
M	YMR049C	ERB1	2129	-491.4	4	Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Ytm1p that is required for maturation of the large ribosomal subunit; required for maturation of the 25S and 5.8S ribosomal RNAs; homologous to mammalian Bop1 [Source:SGD;Acc:S000004652]
M	YMR050C	YMR050C	4931	-2294.2	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000004653]
M	YMR051C	YMR051C	4593	-1612.1	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000004654]
M	YMR052C-A	YMR052C-A	3	-2.1	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004655]
M	YMR052W	FAR3	99	-132.8	4	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum [Source:SGD;Acc:S000004656]
M	YMR053C	STB2	102	-113.7	4	Protein that interacts with Sin3p in a two-hybrid assay and is part of a large protein complex with Sin3p and Stb1p [Source:SGD;Acc:S000004657]
M	YMR054W	STV1	756	-342.6	4	Subunit a of the vacuolar-ATPase V0 domain, one of two isoforms (Stv1p and Vph1p); Stv1p is located in V-ATPase complexes of the Golgi and endosomes while Vph1p is located in V-ATPase complexes of the vacuole [Source:SGD;Acc:S000004658]
M	YMR055C	BUB2	65	-78.9	4	Mitotic exit network regulator, forms GTPase-activating Bfa1p-Bub2p complex that binds Tem1p and spindle pole bodies, blocks cell cycle progression before anaphase in response to spindle and kinetochore damage [Source:SGD;Acc:S000004659]
M	YMR056C	AAC1	1995	-342.8	4	Mitochondrial inner membrane ADP/ATP translocator, exchanges cytosolic ADP for mitochondrially synthesized ATP; phosphorylated; Aac1p is a minor isoform while Pet9p is the major ADP/ATP translocator [Source:SGD;Acc:S000004660]
M	YMR057C	YMR057C	1	-1.5	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF AAC1 [Source:SGD;Acc:S000004661]
M	YMR058W	FET3	986	-395.2	4	Ferro-O2-oxidoreductase required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases [Source:SGD;Acc:S000004662]
M	YMR059W	SEN15	41	-52.1	4	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p [Source:SGD;Acc:S000004663]
M	YMR060C	SAM37	385	-232.1	4	Component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; contributes to SAM complex stability [Source:SGD;Acc:S000004664]
M	YMR061W	RNA14	739	-455.4	4	Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; bridges interaction between Rna15p and Hrp1p in  F I complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; required for gene looping [Source:SGD;Acc:S000004665]
M	YMR062C	ARG7	1620	-525.8	4	Mitochondrial ornithine acetyltransferase, catalyzes the fifth step in arginine biosynthesis; also possesses acetylglutamate synthase activity, regenerates acetylglutamate while forming ornithine [Source:SGD;Acc:S000004666]
M	YMR063W	RIM9	8	-6.3	2	Protein of unknown function, involved in the proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans PalI; putative membrane protein [Source:SGD;Acc:S000004667]
M	YMR064W	AEP1	93	-119.2	4	Protein required for expression of the mitochondrial OLI1 gene encoding subunit 9 of F1-F0 ATP synthase [Source:SGD;Acc:S000004668]
M	YMR065W	KAR5	14	-21.9	2	Protein required for nuclear membrane fusion during karyogamy, localizes to the membrane with a soluble portion in the endoplasmic reticulum lumen, may form a complex with Jem1p and Kar2p; expression of the gene is regulated by pheromone [Source:SGD;Acc:S000004669]
M	YMR066W	SOV1	283	-224.5	4	Mitochondrial protein of unknown function [Source:SGD;Acc:S000004670]
M	YMR067C	UBX4	671	-273.3	4	UBX domain-containing protein that interacts with Cdc48p; involved in degradation of polyubiquitinated proteins via the ERAD (ER-associated degradation) pathway; modulates the Cdc48p-Nplp-Ufd1p AAA ATPase complex during its role in delivery of misfo  roteins to the proteasome [Source:SGD;Acc:S000004671]
M	YMR068W	AVO2	203	-53.8	4	Component of a complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth [Source:SGD;Acc:S000004672]
M	YMR069W	NAT4	57	-23.2	4	N alpha-acetyl-transferase, involved in acetylation of the N-terminal residues of histones H4 and H2A [Source:SGD;Acc:S000004673]
M	YMR070W	MOT3	357	-150.8	4	Nuclear transcription factor with two Cys2-His2 zinc fingers; involved in repression of a subset of hypoxic genes by Rox1p, repression of several DAN/TIR genes during aerobic growth, and repression of ergosterol biosynthetic genes; can form the [MOT  ion [Source:SGD;Acc:S000004674]
M	YMR071C	TVP18	631	-109.8	4	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000004675]
M	YMR072W	ABF2	1527	-271.2	4	Mitochondrial DNA-binding protein involved in mitochondrial DNA replication and recombination, member of HMG1 DNA-binding protein family; activity may be regulated by protein kinase A phosphorylation [Source:SGD;Acc:S000004676]
M	YMR073C	IRC21	207	-84.4	4	Putative protein of unknown function; may be involved in resistance to carboplatin and cisplatin; null mutant displays increase in spontaneous Rad52p foci; contains a lipid-binding domain and binds cardiolipin in a large-scale study [Source:SGD;Acc:S000004677]
M	YMR074C	YMR074C	1204	-191.1	4	Protein with homology to human PDCD5, which is involved in programmed cell death; N-terminal region forms a conserved triple-helix bundle structure; overexpression promotes H2O2-induced apoptosis; YMR074C is not an essential gene [Source:SGD;Acc:S000004678]
M	YMR075C-A	YMR075C-A	2	-1.7	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RCO1/YMR075W [Source:SGD;Acc:S000004679]
M	YMR075W	RCO1	518	-345.3	4	Essential subunit of the histone deacetylase Rpd3S complex; interacts with Eaf3p [Source:SGD;Acc:S000004680]
M	YMR076C	PDS5	677	-649.7	4	Protein required for establishment and maintenance of sister chromatid condensation and cohesion, colocalizes with cohesin on chromosomes, may function as a protein-protein interaction scaffold; also required during meiosis [Source:SGD;Acc:S000004681]
M	YMR077C	VPS20	124	-72.6	4	Myristoylated subunit of ESCRTIII, the endosomal sorting complex required for transport of transmembrane proteins into the multivesicular body pathway to the lysosomal/vacuolar lumen; cytoplasmic protein recruited to endosomal membranes [Source:SGD;Acc:S000004682]
M	YMR078C	CTF18	319	-246.3	4	Subunit of a complex with Ctf8p that shares some subunits with Replication Factor C and is required for sister chromatid cohesion; may have overlapping functions with Rad24p in the DNA damage replication checkpoint [Source:SGD;Acc:S000004683]
M	YMR079W	SEC14	2460	-659.6	4	Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; functionally homologous to mammalian PITPs [Source:SGD;Acc:S000004684]
M	YMR080C	NAM7	1244	-525.1	4	ATP-dependent RNA helicase of the SFI superfamily involved in nonsense mediated mRNA decay; required for efficient translation termination at nonsense codons and targeting of NMD substrates to P-bodies; involved in telomere maintenance [Source:SGD;Acc:S000004685]
M	YMR081C	ISF1	112	-40.4	4	Serine-rich, hydrophilic protein with similarity to Mbr1p; overexpression suppresses growth defects of hap2, hap3, and hap4 mutants; expression is under glucose control; cotranscribed with NAM7 in a cyp1 mutant [Source:SGD;Acc:S000004686]
M	YMR082C	YMR082C	7	-4.8	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004687]
M	YMR083W	ADH3	2641	-631.1	4	Mitochondrial alcohol dehydrogenase isozyme III; involved in the shuttling of mitochondrial NADH to the cytosol under anaerobic conditions and ethanol production [Source:SGD;Acc:S000004688]
M	YMR084W	YMR084W	41	-10	2	Putative protein of unknown function; YMR084W and adjacent ORF YMR085W are merged in related strains [Source:SGD;Acc:S000004689]
M	YMR085W	YMR085W	14	-12.1	2	Putative protein of unknown function; YMR085W and adjacent ORF YMR084W are merged in related strains [Source:SGD;Acc:S000004690]
M	YMR086C-A	YMR086C-A	1	-5.2	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004691]
M	YMR086W	SEG1	1432	-777.2	4	Component of the eisosome with unknown function; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the cell periphery; expression is repressed by cAMP; similar to A. gossypii SEG gene which is importa   stabilizing eisosomes [Source:SGD;Acc:S000004692]
M	YMR087W	YMR087W	196	-150.7	4	Putative ADP-ribose-1''-monophosphatase that converts ADP-ribose-1''-monophosphate to ADP-ribose; may have a role in tRNA splicing; contains an A1pp domain [Source:SGD;Acc:S000004693]
M	YMR088C	VBA1	107	-102.8	4	Permease of basic amino acids in the vacuolar membrane [Source:SGD;Acc:S000004694]
M	YMR089C	YTA12	873	-522.2	4	Component, with Afg3p, of the mitochondrial inner membrane m-AAA protease that mediates degradation of misfolded or unassembled proteins and is also required for correct assembly of mitochondrial enzyme complexes [Source:SGD;Acc:S000004695]
M	YMR090W	YMR090W	868	-264	4	Putative protein of unknown function with similarity to DTDP-glucose 4,6-dehydratases; GFP-fusion protein localizes to the cytoplasm; up-regulated in response to the fungicide mancozeb; not essential for viability [Source:SGD;Acc:S000004696]
M	YMR091C	NPL6	1211	-315.3	4	Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Ldb7p, and Htl1p to form a module important for a broad range of RSC functions; involved in nuclear protein import and maintenance of proper telomere length [Source:SGD;Acc:S000004697]
M	YMR092C	AIP1	1719	-559.2	4	Actin cortical patch component, interacts with the actin depolymerizing factor cofilin; required to restrict cofilin localization to cortical patches; contains WD repeats [Source:SGD;Acc:S000004698]
M	YMR093W	UTP15	1442	-305.2	4	Nucleolar protein, component of the small subunit (SSU) processome containing the U3 snoRNA that is involved in processing of pre-18S rRNA [Source:SGD;Acc:S000004699]
M	YMR094W	CTF13	80	-93.2	4	Subunit of the CBF3 complex, which binds to the CDE III element of centromeres, bending the DNA upon binding, and may be involved in sister chromatid cohesion during mitosis [Source:SGD;Acc:S000004700]
M	YMR095C	SNO1	62	-94	4	Protein of unconfirmed function, involved in pyridoxine metabolism; expression is induced during stationary phase; forms a putative glutamine amidotransferase complex with Snz1p, with Sno1p serving as the glutaminase [Source:SGD;Acc:S000004701]
M	YMR096W	SNZ1	608	-398.4	4	Protein involved in vitamin B6 biosynthesis; member of a stationary phase-induced gene family; coregulated with SNO1; interacts with Sno1p and with Yhr198p, perhaps as a multiprotein complex containing other Snz and Sno proteins [Source:SGD;Acc:S000004702]
M	YMR097C	MTG1	122	-98	4	Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals [Source:SGD;Acc:S000004703]
M	YMR098C	ATP25	182	-233.2	4	Mitochondrial protein required for the stability of Oli1p (Atp9p) mRNA and for the Oli1p ring formation; YMR098C is not an essential gene [Source:SGD;Acc:S000004704]
M	YMR099C	YMR099C	2208	-553.3	4	Glucose-6-phosphate 1-epimerase (hexose-6-phosphate mutarotase), likely involved in carbohydrate metabolism; GFP-fusion protein localizes to both the nucleus and cytoplasm and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000004705]
M	YMR100W	MUB1	55	-38.1	4	MYND domain-containing protein required for ubiquitination and turnover of Rpn4p; interacts with Ubr2p (E3) and indirectly with Rad6p (E2); short-lived protein degraded in a Ubr2p/Rad6p dependent manner; similar to the A. nidulans samB gene [Source:SGD;Acc:S000004706]
M	YMR101C	SRT1	11	-24	2	Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase [Source:SGD;Acc:S000004707]
M	YMR102C	YMR102C	406	-270.6	4	Protein of unknown function; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance; mutant shows increased resistance to azoles; YMR102C is not an essential gene [Source:SGD;Acc:S000004708]
M	YMR103C	YMR103C	9	-12.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004709]
M	YMR104C	YPK2	1174	-2038.1	4	Protein kinase with similarity to serine/threonine protein kinase Ypk1p; functionally redundant with YPK1 at the genetic level; participates in a signaling pathway required for optimal cell wall integrity; homolog of mammalian kinase SGK [Source:SGD;Acc:S000004710]
M	YMR105C	PGM2	2584	-1446.5	4	Phosphoglucomutase, catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase [Source:SGD;Acc:S000004711]
M	YMR105W-A	YMR105W-A	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000028692]
M	YMR106C	YKU80	202	-186.8	4	Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair [Source:SGD;Acc:S000004712]
M	YMR107W	SPG4	264	-268.7	4	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources [Source:SGD;Acc:S000004713]
M	YMR108W	ILV2	3325	-1164.9	4	Acetolactate synthase, catalyses the first common step in isoleucine and valine biosynthesis and is the target of several classes of inhibitors, localizes to the mitochondria; expression of the gene is under general amino acid control [Source:SGD;Acc:S000004714]
M	YMR109W	MYO5	2290	-1138.4	4	One of two type I myosins; contains proline-rich tail homology 2 (TH2) and SH3 domains; MYO5 deletion has little effect on growth, but myo3 myo5 double deletion causes severe defects in growth and actin cytoskeleton organization [Source:SGD;Acc:S000004715]
M	YMR110C	HFD1	915	-440.1	4	Putative fatty aldehyde dehydrogenase, located in the mitochondrial outer membrane and also in lipid particles; has similarity to human fatty aldehyde dehydrogenase (FALDH) which is implicated in Sjogren-Larsson syndrome [Source:SGD;Acc:S000004716]
M	YMR111C	YMR111C	240	-127.9	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene [Source:SGD;Acc:S000004717]
M	YMR112C	MED11	213	-67.3	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential protein [Source:SGD;Acc:S000004718]
M	YMR113W	FOL3	315	-125	4	Dihydrofolate synthetase, involved in folic acid biosynthesis; catalyzes the conversion of dihydropteroate to dihydrofolate in folate coenzyme biosynthesis [Source:SGD;Acc:S000004719]
M	YMR114C	YMR114C	247	-166.1	4	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and cytoplasm; YMR114C is not an essential gene [Source:SGD;Acc:S000004720]
M	YMR115W	MGR3	386	-293.2	4	Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA [Source:SGD;Acc:S000004721]
M	YMR116C	ASC1	4908	-1716.9	4	G-protein beta subunit and guanine nucleotide dissociation inhibitor for Gpa2p; ortholog of RACK1 that inhibits translation; core component of the small (40S) ribosomal subunit; represses Gcn4p in the absence of amino acid starvation [Source:SGD;Acc:S000004722]
M	YMR117C	SPC24	272	-108.3	4	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering [Source:SGD;Acc:S000004723]
M	YMR118C	SHH3	34	-50.6	4	Protein of unknown function with similarity to succinate dehydrogenase cytochrome b subunit; YMR118C is not an essential gene [Source:SGD;Acc:S000004724]
M	YMR119W	ASI1	86	-83.4	4	Putative integral membrane E3 ubiquitin ligase; acts with Asi2p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals [Source:SGD;Acc:S000004725]
M	YMR119W-A	YMR119W-A	9	-2.5	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004726]
M	YMR120C	ADE17	2875	-1417.6	4	Enzyme of 'de novo' purine biosynthesis containing both 5-aminoimidazole-4-carboxamide ribonucleotide transformylase and inosine monophosphate cyclohydrolase activities, isozyme of Ade16p; ade16 ade17 mutants require adenine and histidine [Source:SGD;Acc:S000004727]
M	YMR121C	RPL15B	3798	-471.8	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl15Ap and has similarity to rat L15 ribosomal protein; binds to 5.8 S rRNA [Source:SGD;Acc:S000004728]
M	YMR122C	YMR122C	4	-2.5	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004729]
M	YMR122W-A	YMR122W-A	94	-34.3	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and endoplasmic reticulum [Source:SGD;Acc:S000007524]
M	YMR123W	PKR1	88	-92.6	4	V-ATPase assembly factor, functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0) [Source:SGD;Acc:S000004730]
M	YMR124W	EPO1	886	-458.2	4	Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization [Source:SGD;Acc:S000004731]
M	YMR125W	STO1	1512	-849.3	4	Large subunit of the nuclear mRNA cap-binding protein complex, interacts with Npl3p to carry nuclear poly(A)+ mRNA to cytoplasm; also involved in nuclear mRNA degradation and telomere maintenance; orthologous to mammalian CBP80 [Source:SGD;Acc:S000004732]
M	YMR126C	DLT1	31	-58.2	2	Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA) [Source:SGD;Acc:S000004733]
M	YMR127C	SAS2	124	-59.3	4	Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family [Source:SGD;Acc:S000004734]
M	YMR128W	ECM16	1182	-634.6	4	Essential DEAH-box ATP-dependent RNA helicase specific to the U3 snoRNP, predominantly nucleolar in distribution, required for 18S rRNA synthesis [Source:SGD;Acc:S000004735]
M	YMR129W	POM152	1302	-1344.8	4	Nuclear pore membrane glycoprotein; may be involved in duplication of nuclear pores and nuclear pore complexes during S-phase; [Source:SGD;Acc:S000004736]
M	YMR130W	YMR130W	448	-195.5	4	Putative protein of unknown function; YMR130W is not an essential gene [Source:SGD;Acc:S000004737]
M	YMR131C	RRB1	1733	-388	4	Essential nuclear protein involved in early steps of ribosome biogenesis; physically interacts with the ribosomal protein Rpl3p [Source:SGD;Acc:S000004738]
M	YMR132C	JLP2	99	-74.5	4	Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein) [Source:SGD;Acc:S000004739]
M	YMR133W	REC114	13	-8	2	Protein involved in early stages of meiotic recombination; possibly involved in the coordination of recombination and meiotic division; mutations lead to premature initiation of the first meiotic division [Source:SGD;Acc:S000004740]
M	YMR134W	ERG29	178	-178.8	4	Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes [Source:SGD;Acc:S000004741]
M	YMR135C	GID8	423	-852.2	4	Protein of unknown function, involved in proteasome-dependent catabolite inactivation of fructose-1,6-bisphosphatase; contains LisH and CTLH domains, like Vid30p; dosage-dependent regulator of START [Source:SGD;Acc:S000004742]
M	YMR135W-A	YMR135W-A	2	-1	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004743]
M	YMR136W	GAT2	52	-16.4	4	Protein containing GATA family zinc finger motifs; similar to Gln3p and Dal80p; expression repressed by leucine [Source:SGD;Acc:S000004744]
M	YMR137C	PSO2	46	-81.8	3	Nuclease required for a post-incision step in the repair of DNA single and double-strand breaks that result from interstrand crosslinks produced by a variety of mono- and bi-functional psoralen derivatives; induced by UV-irradiation [Source:SGD;Acc:S000004745]
M	YMR138W	CIN4	87	-54.6	4	GTP-binding protein involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl; regulated by the GTPase-activating protein, Cin2p, the human retinitis pigmentosa 2 (RP2) homolog [Source:SGD;Acc:S000004746]
M	YMR139W	RIM11	746	-1001.1	4	Protein kinase required for signal transduction during entry into meiosis; promotes the formation of the Ime1p-Ume6p complex by phosphorylating Ime1p and Ume6p; shares similarity with mammalian glycogen synthase kinase 3-beta [Source:SGD;Acc:S000004747]
M	YMR140W	SIP5	784	-314.1	4	Protein of unknown function; interacts with both the Reg1p/Glc7p phosphatase and the Snf1p kinase [Source:SGD;Acc:S000004748]
M	YMR141C	YMR141C	5	-1.6	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004749]
M	YMR141W-A	YMR141W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene RPL13B/YMR142C [Source:SGD;Acc:S000028575]
M	YMR142C	RPL13B	4365	-664.8	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl13Ap; not essential for viability; has similarity to rat L13 ribosomal protein [Source:SGD;Acc:S000004750]
M	YMR143W	RPS16A	4294	-544.6	4	Protein component of the small (40S) ribosomal subunit; identical to Rps16Bp and has similarity to E. coli S9 and rat S16 ribosomal proteins [Source:SGD;Acc:S000004751]
M	YMR144W	YMR144W	208	-57.7	4	Putative protein of unknown function; localized to the nucleus; YMR144W is not an essential gene [Source:SGD;Acc:S000004752]
M	YMR145C	NDE1	1802	-861.5	4	Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain [Source:SGD;Acc:S000004753]
M	YMR146C	TIF34	2519	-510.2	4	eIF3i subunit of the core complex of translation initiation factor 3 (eIF3), which is essential for translation; stimulates rate of ribosomal scanning during translation reinitiation [Source:SGD;Acc:S000004754]
M	YMR147W	YMR147W	216	-87.3	4	Putative protein of unknown function [Source:SGD;Acc:S000004755]
M	YMR148W	OSW5	212	-135.4	4	Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion [Source:SGD;Acc:S000004756]
M	YMR149W	SWP1	975	-136.9	4	Delta subunit of the oligosaccharyl transferase glycoprotein complex, which is required for N-linked glycosylation of proteins in the endoplasmic reticulum [Source:SGD;Acc:S000004757]
M	YMR150C	IMP1	81	-119.6	4	Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p [Source:SGD;Acc:S000004758]
M	YMR151W	YIM2	1	-1.4	1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 [Source:SGD;Acc:S000004759]
M	YMR152W	YIM1	827	-300.2	4	Protein of unknown function; null mutant displays sensitivity to DNA damaging agents; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004760]
M	YMR153C-A	YMR153C-A	1	-2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NUP53 [Source:SGD;Acc:S000004761]
M	YMR153W	NUP53	932	-454.7	4	Subunit of the nuclear pore complex (NPC), interacts with karyopherin Kap121p or with Nup170p via overlapping regions of Nup53p, involved in activation of the spindle checkpoint mediated by the Mad1p-Mad2p complex [Source:SGD;Acc:S000004762]
M	YMR154C	RIM13	87	-112.3	4	Calpain-like cysteine protease involved in proteolytic activation of Rim101p in response to alkaline pH; has similarity to A. nidulans palB [Source:SGD;Acc:S000004763]
M	YMR155W	YMR155W	66	-105.4	4	Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen [Source:SGD;Acc:S000004764]
M	YMR156C	TPP1	124	-54.6	4	DNA 3'-phosphatase that functions in repair of endogenous damage of double-stranded DNA, activity is specific for removal of 3' phosphates at strand breaks; has similarity to the l-2-haloacid dehalogenase superfamily [Source:SGD;Acc:S000004765]
M	YMR157C	AIM36	453	-201.7	4	Protein of unknown function; null mutant displays reduced respiratory growth and elevated frequency of mitochondrial genome loss; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004766]
M	YMR158C-A	YMR158C-A	2	-2.4	2	Putative protein of unknown function, may contain a lipid attachment site; YMR158C-A is not an essential gene [Source:SGD;Acc:S000007249]
M	YMR158W	MRPS8	610	-214.7	4	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000004767]
M	YMR158W-B	YMR158W-B	3	-3.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene ATG16/YMR159C [Source:SGD;Acc:S000004768]
M	YMR159C	ATG16	44	-26.3	4	Conserved protein that interacts with Atg12p-Atg5p conjugates to form Atg12p-Atg5p-Atg16p multimers, which localize to the pre-autophagosomal structure and are required for autophagy [Source:SGD;Acc:S000004769]
M	YMR160W	YMR160W	260	-293.4	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of the vacuole; mutant has enhanced sensitivity to overexpression of mutant huntingtin; YMR160W is not an essential gene [Source:SGD;Acc:S000004770]
M	YMR161W	HLJ1	377	-108.6	4	Co-chaperone for Hsp40p, anchored in the ER membrane; with its homolog Ydj1p promotes ER-associated protein degradation (ERAD) of integral membrane substrates; similar to E. coli DnaJ [Source:SGD;Acc:S000004771]
M	YMR162C	DNF3	324	-393	4	Aminophospholipid translocase (flippase) that maintains membrane lipid asymmetry in post-Golgi secretory vesicles; localizes to the trans-Golgi network; likely involved in protein transport; type 4 P-type ATPase [Source:SGD;Acc:S000004772]
M	YMR163C	INP2	54	-36.1	4	Peroxisome-specific receptor important for peroxisome inheritance; co-fractionates with peroxisome membranes and co-localizes with peroxisomes in vivo; physically interacts with the myosin V motor Myo2p; INP2 is not an essential gene [Source:SGD;Acc:S000004773]
M	YMR164C	MSS11	55	-49.6	4	Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of MUC1 and STA2 in response to nutritional signals [Source:SGD;Acc:S000004774]
M	YMR165C	PAH1	595	-467.4	4	Mg<sup>2+</sup>-dependent phosphatidate (PA) phosphatase, catalyzes the dephosphorylation of PA to yield diacylglycerol, responsible for de novo lipid synthesis and formation of lipid droplets; homologous to mammalian lipin 1 [Source:SGD;Acc:S000004775]
M	YMR166C	YMR166C	44	-90.4	4	Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene [Source:SGD;Acc:S000004776]
M	YMR167W	MLH1	266	-234.9	4	Protein required for mismatch repair in mitosis and meiosis as well as crossing over during meiosis; forms a complex with Pms1p and Msh2p-Msh3p during mismatch repair; human homolog is associated with hereditary non-polyposis colon cancer [Source:SGD;Acc:S000004777]
M	YMR168C	CEP3	80	-114.4	4	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain [Source:SGD;Acc:S000004778]
M	YMR169C	ALD3	1235	-601.8	4	Cytoplasmic aldehyde dehydrogenase, involved in beta-alanine synthesis; uses NAD+ as the preferred coenzyme; very similar to Ald2p; expression is induced by stress and repressed by glucose [Source:SGD;Acc:S000004779]
M	YMR170C	ALD2	1201	-506.6	4	Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p [Source:SGD;Acc:S000004780]
M	YMR171C	EAR1	254	-116.2	4	Specificity factor required for Rsp5p-dependent ubiquitination and sorting of specific cargo proteins at the multivesicular body; mRNA is targeted to the bud via the mRNA transport system involving She2p [Source:SGD;Acc:S000004781]
M	YMR172C-A	YMR172C-A	2	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004782]
M	YMR172W	HOT1	221	-801.7	4	Transcription factor required for the transient induction of glycerol biosynthetic genes GPD1 and GPP2 in response to high osmolarity; targets Hog1p to osmostress responsive promoters; has similarity to Msn1p and Gcr1p [Source:SGD;Acc:S000004783]
M	YMR173W	DDR48	1866	-1407.1	4	DNA damage-responsive protein, expression is increased in response to heat-shock stress or treatments that produce DNA lesions; contains multiple repeats of the amino acid sequence NNNDSYGS [Source:SGD;Acc:S000004784]
M	YMR173W-A	YMR173W-A	198	-76.8	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene DDR48/YML173W [Source:SGD;Acc:S000004785]
M	YMR174C	PAI3	334	-73.8	4	Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact [Source:SGD;Acc:S000004786]
M	YMR175W	SIP18	136	-126.1	4	Phospholipid-binding hydrophilin with a role in dessication resistance; expression is induced by osmotic stress [Source:SGD;Acc:S000004787]
M	YMR175W-A	YMR175W-A	3	-1.3	1	Putative protein of unknown function [Source:SGD;Acc:S000028848]
M	YMR176W	ECM5	110	-88.8	4	Non-essential protein of unknown function, contains ATP/GTP-binding site motif A; null mutant exhibits cellular volume up to four times greater than wild-type, also large drooping buds with elongated necks [Source:SGD;Acc:S000004788]
M	YMR177W	MMT1	118	-99.6	4	Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt2p [Source:SGD;Acc:S000004789]
M	YMR178W	YMR178W	969	-291.9	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR178W is not an essential gene [Source:SGD;Acc:S000004790]
M	YMR179W	SPT21	66	-32.9	2	Protein with a role in transcriptional silencing; required for normal transcription at several loci including HTA2-HTB2 and HHF2-HHT2, but not required at the other histone loci; functionally related to Spt10p [Source:SGD;Acc:S000004791]
M	YMR180C	CTL1	42	-27.4	4	RNA 5'-triphosphatase, localizes to both the nucleus and cytoplasm [Source:SGD;Acc:S000004792]
M	YMR181C	YMR181C	122	-35.4	4	Protein of unknown function; mRNA transcribed as part of a bicistronic transcript with a predicted transcriptional repressor RGM1/YMR182C; mRNA is destroyed by nonsense-mediated decay (NMD); YMR181C is not an essential gene [Source:SGD;Acc:S000004793]
M	YMR182C	RGM1	13	-13.7	4	Putative transcriptional repressor with proline-rich zinc fingers; overproduction impairs cell growth [Source:SGD;Acc:S000004794]
M	YMR182W-A	YMR182W-A	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000028693]
M	YMR183C	SSO2	1512	-450.5	4	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane; syntaxin homolog that is functionally redundant with Sso1p [Source:SGD;Acc:S000004795]
M	YMR184W	ADD37	304	-75.5	4	Protein of unknown function involved in ER-associated protein degradation; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YMR184W is not an essential gene [Source:SGD;Acc:S000004796]
M	YMR185W	RTP1	138	-216	4	Putative protein of unknown function; conflicting evidence on whether null mutant is viable with elongated buds, or inviable [Source:SGD;Acc:S000004797]
M	YMR186W	HSC82	5949	-2162.8	4	Cytoplasmic chaperone of the Hsp90 family, redundant in function and nearly identical with Hsp82p, and together they are essential; expressed constitutively at 10-fold higher basal levels than HSP82 and induced 2-3 fold by heat shock [Source:SGD;Acc:S000004798]
M	YMR187C	YMR187C	68	-49.7	2	Putative protein of unknown function; YMR187C is not an essential gene [Source:SGD;Acc:S000004799]
M	YMR188C	MRPS17	517	-201.9	4	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000004800]
M	YMR189W	GCV2	1633	-1446	4	P subunit of the mitochondrial glycine decarboxylase complex, required for the catabolism of glycine to 5,10-methylene-THF; expression is regulated by levels of 5,10-methylene-THF in the cytoplasm [Source:SGD;Acc:S000004801]
M	YMR190C	SGS1	116	-97.8	4	Nucleolar DNA helicase of the RecQ family; involved in genome integrity maintenance; regulates chromosome synapsis and meiotic joint molecule/crossover formation; potential role as repressor of a subset of rapamycin responsive genes; rapidly lost in  nse to rapamycin in Rrd1p-dependent manner; similar to human BLM and WRN proteins implicated in Bloom and Werner syndromes [Source:SGD;Acc:S000004802]
M	YMR191W	SPG5	18	-33.7	2	Protein required for survival at high temperature during stationary phase; not required for growth on nonfermentable carbon sources [Source:SGD;Acc:S000004803]
M	YMR192W	GYL1	809	-542	4	Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud ti  ng polarized growth [Source:SGD;Acc:S000004804]
M	YMR193C-A	YMR193C-A	1	-1	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004805]
M	YMR193W	MRPL24	460	-174.3	4	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene [Source:SGD;Acc:S000004806]
M	YMR194C-A	YMR194C-A	1	-2.3	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007250]
M	YMR194C-B	CMC4	85	-46.4	4	Protein that localizes to the mitochondrial intermembrane space via the Mia40p-Erv1p system; contains twin cysteine-x(9)-cysteine motifs [Source:SGD;Acc:S000028514]
M	YMR194W	RPL36A	3356	-313.1	4	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Bp and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA [Source:SGD;Acc:S000004807]
M	YMR195W	ICY1	8	-5.4	3	Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation [Source:SGD;Acc:S000004808]
M	YMR196W	YMR196W	1347	-1017.4	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR196W is not an essential gene [Source:SGD;Acc:S000004809]
M	YMR197C	VTI1	833	-165.3	4	Protein involved in cis-Golgi membrane traffic; v-SNARE that interacts with two t-SNARES, Sed5p and Pep12p; required for multiple vacuolar sorting pathways [Source:SGD;Acc:S000004810]
M	YMR198W	CIK1	54	-86.8	4	Kinesin-associated protein required for both karyogamy and mitotic spindle organization, interacts stably and specifically with Kar3p and may function to target this kinesin to a specific cellular role; has similarity to Vik1p [Source:SGD;Acc:S000004811]
M	YMR199W	CLN1	63	-1476.3	4	G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) [Source:SGD;Acc:S000004812]
M	YMR200W	ROT1	248	-56.6	4	Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations [Source:SGD;Acc:S000004813]
M	YMR201C	RAD14	90	-136.5	4	Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein [Source:SGD;Acc:S000004814]
M	YMR202W	ERG2	1081	-294.2	4	C-8 sterol isomerase, catalyzes the isomerization of the delta-8 double bond to the delta-7 position at an intermediate step in ergosterol biosynthesis [Source:SGD;Acc:S000004815]
M	YMR203W	TOM40	2122	-728.3	4	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; constitutes the core element of the protein conducting pore [Source:SGD;Acc:S000004816]
M	YMR204C	INP1	67	-43.9	4	Peripheral membrane protein of peroxisomes involved in peroxisomal inheritance; recruitment to peroxisomes is mediated by interaction with Pex3p at the peroxisomal membrane [Source:SGD;Acc:S000004817]
M	YMR205C	PFK2	4350	-1667.6	4	Beta subunit of heterooctameric phosphofructokinase involved in glycolysis, indispensable for anaerobic growth, activated by fructose-2,6-bisphosphate and AMP, mutation inhibits glucose induction of cell cycle-related genes [Source:SGD;Acc:S000004818]
M	YMR206W	YMR206W	70	-91.4	4	Putative protein of unknown function; YMR206W is not an essential gene [Source:SGD;Acc:S000004819]
M	YMR207C	HFA1	1854	-369.1	4	Mitochondrial acetyl-coenzyme A carboxylase, catalyzes the production of malonyl-CoA in mitochondrial fatty acid biosynthesis [Source:SGD;Acc:S000004820]
M	YMR208W	ERG12	1177	-1125.7	4	Mevalonate kinase, acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate [Source:SGD;Acc:S000004821]
M	YMR209C	YMR209C	373	-263.8	4	Putative S-adenosylmethionine-dependent methyltransferase; YMR209C is not an essential gene [Source:SGD;Acc:S000004822]
M	YMR210W	YMR210W	134	-187.2	4	Putative acyltransferase with similarity to Eeb1p and Eht1p, has a minor role in medium-chain fatty acid ethyl ester biosynthesis; may be involved in lipid metabolism and detoxification [Source:SGD;Acc:S000004823]
M	YMR211W	DML1	169	-97.2	4	Essential protein involved in mtDNA inheritance, may also function in the partitioning of the mitochondrial organelle or in the segregation of chromosomes, exhibits regions similar to members of a GTPase family [Source:SGD;Acc:S000004824]
M	YMR212C	EFR3	1030	-451.4	4	Protein required for Stt4-containing phosphoinositide kinase patch assembly at the plasma membrane; exhibits synthetic lethal genetic interactions with PHO85; has sequence similarity to the Drosophila rolling blackout (RBO) gene [Source:SGD;Acc:S000004825]
M	YMR213W	CEF1	227	-381	4	Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p [Source:SGD;Acc:S000004826]
M	YMR214W	SCJ1	1008	-302.3	4	One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins [Source:SGD;Acc:S000004827]
M	YMR215W	GAS3	1248	-399.8	4	Low abundance, possibly inactive member of the GAS family of GPI-containing proteins; putative 1,3-beta-glucanosyltransferase with similarity to other GAS family members; localizes to the cell wall; mRNA induced during sporulation [Source:SGD;Acc:S000004828]
M	YMR216C	SKY1	955	-2337.5	4	SR protein kinase (SRPK) involved in regulating proteins involved in mRNA metabolism and cation homeostasis; similar to human SRPK1 [Source:SGD;Acc:S000004829]
M	YMR217W	GUA1	3040	-861.8	4	GMP synthase; highly conserved enzyme that catalyzes the second step in the biosynthesis of GMP from inosine 5'-phosphate (IMP); transcription is not subject to regulation by guanine but is negatively regulated by nutrient starvation; reduction-of-f  n mutation gua1-G388D causes changes in cellular guanine nucleotide pools, defects in general protein synthesis, and impaired translation of GCN4 mRNA [Source:SGD;Acc:S000004830]
M	YMR218C	TRS130	179	-292.8	4	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1 [Source:SGD;Acc:S000004831]
M	YMR219W	ESC1	1117	-909.5	4	Protein localized to the nuclear periphery, involved in telomeric silencing; interacts with PAD4-domain of Sir4p [Source:SGD;Acc:S000004832]
M	YMR220W	ERG8	898	-397.3	4	Phosphomevalonate kinase, an essential cytosolic enzyme that acts in the biosynthesis of isoprenoids and sterols, including ergosterol, from mevalonate [Source:SGD;Acc:S000004833]
M	YMR221C	YMR221C	445	-106.2	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; physical interaction with Atg27p suggests a possible role in autophagy [Source:SGD;Acc:S000004834]
M	YMR222C	FSH2	390	-61.9	4	Putative serine hydrolase that localizes to the cytoplasm; sequence is similar to S. cerevisiae Fsh1p and Fsh3p and the human candidate tumor suppressor OVCA2 [Source:SGD;Acc:S000004835]
M	YMR223W	UBP8	449	-549.8	4	Ubiquitin-specific protease that is a component of the SAGA (Spt-Ada-Gcn5-Acetyltransferase) acetylation complex; required for SAGA-mediated deubiquitination of histone H2B [Source:SGD;Acc:S000004836]
M	YMR224C	MRE11	354	-252.1	4	Subunit of a complex with Rad50p and Xrs2p (MRX complex) that functions in repair of DNA double-strand breaks and in telomere stability, exhibits nuclease activity that appears to be required for MRX function; widely conserved [Source:SGD;Acc:S000004837]
M	YMR225C	MRPL44	191	-66.5	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000004838]
M	YMR226C	YMR226C	2590	-457	4	NADP(+)-dependent dehydrogenase; acts on serine, L-allo-threonine, and other 3-hydroxy acids; green fluorescent protein fusion protein localizes to the cytoplasm and nucleus; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000004839]
M	YMR227C	TAF7	346	-817.1	4	TFIID subunit (67 kDa), involved in RNA polymerase II transcription initiation [Source:SGD;Acc:S000004840]
M	YMR228W	MTF1	266	-149.9	4	Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; binding of Mtf1p to the core polymerase (Rpo41p)-promoter complex s  zes the binding and induces DNA bending [Source:SGD;Acc:S000004841]
M	YMR229C	RRP5	3075	-1519.4	4	RNA binding protein with preference for single stranded tracts of U's involved in synthesis of both 18S and 5.8S rRNAs; component of both the ribosomal small subunit (SSU) processosome and the 90S preribosome [Source:SGD;Acc:S000004842]
M	YMR230W	RPS10B	3010	-362.2	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Ap and has similarity to rat ribosomal protein S10 [Source:SGD;Acc:S000004843]
M	YMR230W-A	YMR230W-A	18	-3.3	2	Putative protein of unknown function [Source:SGD;Acc:S000028576]
M	YMR231W	PEP5	509	-360.9	4	Component of CORVET tethering complex; peripheral vacuolar membrane protein required for protein trafficking and vacuole biogenesis; interacts with Pep7p [Source:SGD;Acc:S000004844]
M	YMR232W	FUS2	37	-13.2	2	Cytoplasmic protein localized to the shmoo tip; required for the alignment of parental nuclei before nuclear fusion during mating [Source:SGD;Acc:S000004845]
M	YMR233W	TRI1	234	-106.9	4	Non-essential sumoylated protein of unknown function with similarity to components of human SWI/SNF complex including SMRD3; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm, nucleus and nucleolus [Source:SGD;Acc:S000004846]
M	YMR234W	RNH1	98	-84.3	4	Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201) [Source:SGD;Acc:S000004847]
M	YMR235C	RNA1	2364	-657.7	4	GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport [Source:SGD;Acc:S000004848]
M	YMR236W	TAF9	549	-731.7	4	Subunit (17 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H3 [Source:SGD;Acc:S000004849]
M	YMR237W	BCH1	1159	-416.4	4	Member of the ChAPs family (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins from the Golgi to the plasma membrane; may interact with ribosomes [Source:SGD;Acc:S000004850]
M	YMR238W	DFG5	446	-147.3	4	Putative mannosidase, essential glycosylphosphatidylinositol (GPI)-anchored membrane protein required for cell wall biogenesis in bud formation, involved in filamentous growth, homologous to Dcw1p [Source:SGD;Acc:S000004851]
M	YMR239C	RNT1	517	-217.1	4	RNAase III; involved in rDNA transcription and rRNA processing; also cleaves a stem-loop structure at the 3' end of U2 snRNA to ensure formation of the correct U2 3' end; involved in polyadenylation-independent transcription termination [Source:SGD;Acc:S000004852]
M	YMR240C	CUS1	297	-222.8	4	Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p [Source:SGD;Acc:S000004853]
M	YMR241W	YHM2	1965	-404.1	4	Carrier protein that exports citrate from and imports oxoglutarate into the mitochondrion, causing net export of NADPH reducing equivalents; also associates with mt nucleoids and has a role in replication and segregation of the mt genome [Source:SGD;Acc:S000004854]
M	YMR242C	RPL20A	4112	-655.3	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Bp and has similarity to rat L18a ribosomal protein [Source:SGD;Acc:S000004855]
M	YMR242W-A	YMR242W-A	1	-1.1	1	Putative protein of unknown function [Source:SGD;Acc:S000028694]
M	YMR243C	ZRC1	1321	-298.9	4	Vacuolar membrane zinc transporter, transports zinc from the cytosol into the vacuole for storage; also has a role in resistance to zinc shock resulting from a sudden influx of zinc into the cytoplasm [Source:SGD;Acc:S000004856]
M	YMR244C-A	COA6	342	-124.4	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced in response to the DNA-damaging agent MMS; YMR244C-A is not an essential gene [Source:SGD;Acc:S000004857]
M	YMR244W	YMR244W	11	-2.7	2	Putative protein of unknown function [Source:SGD;Acc:S000004858]
M	YMR245W	YMR245W	5	-2.3	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004859]
M	YMR246W	FAA4	2197	-685.1	4	Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; important for survival during stationary phase; localized to lipid particles [Source:SGD;Acc:S000004860]
M	YMR247C	RKR1	764	-648.5	4	RING domain E3 ubiquitin ligase; involved in the ubiquitin-mediated degradation of non-stop proteins; functional connections to chromatin modification; nuclear protein that also co-localizes with ribosomes; homolog of mouse Listerin, whose mutation   en reported to cause neurodegeneration in mice [Source:SGD;Acc:S000004861]
M	YMR247W-A	YMR247W-A	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000028849]
M	YMR250W	GAD1	1165	-653.3	4	Glutamate decarboxylase, converts glutamate into gamma-aminobutyric acid (GABA) during glutamate catabolism; involved in response to oxidative stress [Source:SGD;Acc:S000004862]
M	YMR251W	GTO3	28	-131.3	4	Omega class glutathione transferase; putative cytosolic localization [Source:SGD;Acc:S000004863]
M	YMR251W-A	HOR7	158	-24.8	4	Protein of unknown function; overexpression suppresses Ca2+ sensitivity of mutants lacking inositol phosphorylceramide mannosyltransferases Csg1p and Csh1p; transcription is induced under hyperosmotic stress and repressed by alpha factor [Source:SGD;Acc:S000004864]
M	YMR252C	YMR252C	5	-13.5	2	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YMR252C is not an essential gene [Source:SGD;Acc:S000004865]
M	YMR253C	YMR253C	210	-69.8	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; YMR253C is not an essential gene [Source:SGD;Acc:S000004866]
M	YMR254C	YMR254C	2	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004867]
M	YMR255W	GFD1	559	-89.6	4	Coiled-coiled protein of unknown function, identified as a high-copy suppressor of a dbp5 mutation [Source:SGD;Acc:S000004868]
M	YMR256C	COX7	132	-46.1	4	Subunit VII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain [Source:SGD;Acc:S000004869]
M	YMR257C	PET111	50	-117.5	2	Mitochondrial translational activator specific for the COX2 mRNA; located in the mitochondrial inner membrane [Source:SGD;Acc:S000004870]
M	YMR258C	ROY1	235	-237.8	4	GTPase inhibitor with similarity to F-box proteins; inhibits Ypt52p GTPase activity by preventing Ypt52p from binding GTP; involved in regulating intracellular trafficking; physically interacts with Skp1p [Source:SGD;Acc:S000004871]
M	YMR259C	TRM732	688	-620	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YMR259C is not an essential gene [Source:SGD;Acc:S000004872]
M	YMR260C	TIF11	1866	-204.5	4	Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 [Source:SGD;Acc:S000004873]
M	YMR261C	TPS3	2167	-848.6	4	Regulatory subunit of trehalose-6-phosphate synthase/phosphatase complex, which synthesizes the storage carbohydrate trehalose; expression is induced by stress conditions and repressed by the Ras-cAMP pathway [Source:SGD;Acc:S000004874]
M	YMR262W	YMR262W	124	-196.3	4	Protein of unknown function; interacts weakly with Knr4p; YMR262W is not an essential gene [Source:SGD;Acc:S000004875]
M	YMR263W	SAP30	208	-71.2	4	Subunit of a histone deacetylase complex, along with Rpd3p and Sin3p, that is involved in silencing at telomeres, rDNA, and silent mating-type loci; involved in telomere maintenance [Source:SGD;Acc:S000004876]
M	YMR264W	CUE1	595	-240	4	Endoplasmic reticulum membrane protein that recruits the ubiquitin-conjugating enzyme Ubc7p to the ER where it functions in protein degradation; contains a CUE domain that binds ubiquitin to facilitate intramolecular monoubiquitination [Source:SGD;Acc:S000004877]
M	YMR265C	YMR265C	77	-147.5	4	Putative protein of unknown function [Source:SGD;Acc:S000004878]
M	YMR266W	RSN1	807	-338.8	4	Membrane protein of unknown function; overexpression suppresses NaCl sensitivity of sro7 mutant cells by restoring sodium pump (Ena1p) localization to the plasma membrane [Source:SGD;Acc:S000004879]
M	YMR267W	PPA2	379	-139.6	4	Mitochondrial inorganic pyrophosphatase, required for mitochondrial function and possibly involved in energy generation from inorganic pyrophosphate [Source:SGD;Acc:S000004880]
M	YMR268C	PRP24	156	-95	4	Splicing factor that reanneals U4 and U6 snRNPs during spliceosome recycling [Source:SGD;Acc:S000004881]
M	YMR269W	TMA23	621	-92.2	4	Nucleolar protein implicated in ribosome biogenesis; deletion extends chronological lifespan [Source:SGD;Acc:S000004882]
M	YMR270C	RRN9	108	-146.4	4	Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I [Source:SGD;Acc:S000004883]
M	YMR271C	URA10	981	-168.5	4	Minor orotate phosphoribosyltransferase (OPRTase) isozyme that catalyzes the fifth enzymatic step in the de novo biosynthesis of pyrimidines, converting orotate into orotidine-5'-phosphate; major OPRTase encoded by URA5 [Source:SGD;Acc:S000004884]
M	YMR272C	SCS7	948	-148.5	4	Sphingolipid alpha-hydroxylase, functions in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids, has both cytochrome b5-like and hydroxylase/desaturase domains, not essential for growth [Source:SGD;Acc:S000004885]
M	YMR272W-A	YMR272W-A	5	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene SCS7/YMR272C [Source:SGD;Acc:S000028695]
M	YMR272W-B	YMR272W-B	0	nf	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028696]
M	YMR273C	ZDS1	409	-358.1	4	Protein with a role in regulating Swe1p-dependent polarized growth; interacts with silencing proteins at the telomere; has a role in Bcy1p localization; implicated in mRNA nuclear export; involved in mitotic exit through Cdc14p regulation [Source:SGD;Acc:S000004886]
M	YMR274C	RCE1	8	-18.7	3	Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone [Source:SGD;Acc:S000004887]
M	YMR275C	BUL1	873	-341.2	4	Ubiquitin-binding component of the Rsp5p E3-ubiquitin ligase complex, functional homolog of Bul2p, disruption causes temperature-sensitive growth, overexpression causes missorting of amino acid permeases [Source:SGD;Acc:S000004888]
M	YMR276W	DSK2	1682	-315.7	4	Nuclear-enriched ubiquitin-like polyubiquitin-binding protein, required for spindle pole body (SPB) duplication and for transit through the G2/M phase of the cell cycle, involved in proteolysis, interacts with the proteasome [Source:SGD;Acc:S000004889]
M	YMR277W	FCP1	482	-313.7	4	Carboxy-terminal domain (CTD) phosphatase, essential for dephosphorylation of the repeated C-terminal domain of the RNA polymerase II large subunit (Rpo21p) [Source:SGD;Acc:S000004890]
M	YMR278W	PRM15	818	-429.5	4	Phosphoglucomutase, catalyzes interconversion of glucose-1-phosphate and glucose-6-phospate; transcription induced in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; non-essential [Source:SGD;Acc:S000004891]
M	YMR279C	YMR279C	2	-2.9	2	Putative boron transporter involved in boron efflux and resistance; overexpression mutant but not null mutant displays boron tolerance phenotype; identified as a heat-induced gene in a high-throughout screen; YMR279C is not an essential gene; paralo  he efflux pump ATR1 [Source:SGD;Acc:S000004892]
M	YMR280C	CAT8	278	-458	4	Zinc cluster transcriptional activator necessary for derepression of a variety of genes under non-fermentative growth conditions, active after diauxic shift, binds carbon source responsive elements [Source:SGD;Acc:S000004893]
M	YMR281W	GPI12	106	-54.7	4	ER membrane protein involved in the second step of glycosylphosphatidylinositol (GPI) anchor assembly, the de-N-acetylation of the N-acetylglucosaminylphosphatidylinositol intermediate; functional homolog of human PIG-Lp [Source:SGD;Acc:S000004894]
M	YMR282C	AEP2	201	-239.4	4	Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader [Source:SGD;Acc:S000004895]
M	YMR283C	RIT1	76	-98	4	2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA [Source:SGD;Acc:S000004896]
M	YMR284W	YKU70	116	-202.9	4	Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair [Source:SGD;Acc:S000004897]
M	YMR285C	NGL2	709	-290.4	4	Protein involved in 5.8S rRNA processing; Ccr4p-like RNase required for correct 3'-end formation of 5.8S rRNA at site E; similar to Ngl1p and Ngl3p [Source:SGD;Acc:S000004898]
M	YMR286W	MRPL33	310	-128	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000004899]
M	YMR287C	DSS1	219	-133.7	4	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs [Source:SGD;Acc:S000004900]
M	YMR288W	HSH155	537	-401.6	4	U2-snRNP associated splicing factor that forms extensive associations with the branch site-3' splice site-3' exon region upon prespliceosome formation; similarity to the mammalian U2 snRNP-associated splicing factor SAP155 [Source:SGD;Acc:S000004901]
M	YMR289W	ABZ2	238	-225.5	4	Aminodeoxychorismate lyase (4-amino-4-deoxychorismate lyase), catalyzes the third step in para-aminobenzoic acid biosynthesis; involved in folic acid biosynthesis [Source:SGD;Acc:S000004902]
M	YMR290C	HAS1	2193	-403.5	4	ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles [Source:SGD;Acc:S000004903]
M	YMR290W-A	YMR290W-A	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps 5' end of essential HAS1 gene which encodes an ATP-dependent RNA helicase [Source:SGD;Acc:S000004904]
M	YMR291W	TDA1	771	-817.9	4	Putative kinase of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; null mutant is sensitive to expression of the top1-T722A allele; not an essential gene [Source:SGD;Acc:S000004905]
M	YMR292W	GOT1	30	-35.8	4	Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition [Source:SGD;Acc:S000004906]
M	YMR293C	HER2	221	-238.6	4	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; required for remodeling of ER caused by Hmg2p overexpression; similar to bacterial GatA glutamyl-tRNA amidotransferase [Source:SGD;Acc:S000004907]
M	YMR294W	JNM1	118	-100.4	4	Component of the yeast dynactin complex, consisting of Nip100p, Jnm1p, and Arp1p; required for proper nuclear migration and spindle partitioning during mitotic anaphase B [Source:SGD;Acc:S000004908]
M	YMR294W-A	YMR294W-A	2	-1.3	1	Dubious open reading frame unlikely to encode a functional protein, substantially overlaps YMR295C; deletion causes sensitivity to unfolded protein response-inducing agents [Source:SGD;Acc:S000004909]
M	YMR295C	YMR295C	1331	-142.1	4	Protein of unknown function that associates with ribosomes; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and bud; YMR295C is not an essential gene [Source:SGD;Acc:S000004910]
M	YMR296C	LCB1	1596	-412.5	4	Component of serine palmitoyltransferase, responsible along with Lcb2p for the first committed step in sphingolipid synthesis, which is the condensation of serine with palmitoyl-CoA to form 3-ketosphinganine [Source:SGD;Acc:S000004911]
M	YMR297W	PRC1	1432	-715	4	Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family [Source:SGD;Acc:S000004912]
M	YMR298W	LIP1	422	-118	4	Ceramide synthase subunit; single-span ER membrane protein associated with Lag1p and Lac1p and required for ceramide synthase activity, null mutant grows extremely slowly and is defective in ceramide synthesis [Source:SGD;Acc:S000004913]
M	YMR299C	DYN3	30	-50.9	4	Dynein light intermediate chain (LIC); localizes with dynein, null mutant is defective in nuclear migration [Source:SGD;Acc:S000004914]
M	YMR300C	ADE4	2000	-825.6	4	Phosphoribosylpyrophosphate amidotransferase (PRPPAT; amidophosphoribosyltransferase), catalyzes first step of the 'de novo' purine nucleotide biosynthetic pathway [Source:SGD;Acc:S000004915]
M	YMR301C	ATM1	389	-184	4	Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol [Source:SGD;Acc:S000004916]
M	YMR302C	YME2	863	-583.5	4	Integral inner mitochondrial membrane protein with a role in maintaining mitochondrial nucleoid structure and number; mutants exhibit an increased rate of mitochondrial DNA escape; shows some sequence similarity to exonucleases [Source:SGD;Acc:S000004917]
M	YMR303C	ADH2	5629	-1277.6	4	Glucose-repressible alcohol dehydrogenase II, catalyzes the conversion of ethanol to acetaldehyde; involved in the production of certain carboxylate esters; regulated by ADR1 [Source:SGD;Acc:S000004918]
M	YMR304C-A	YMR304C-A	14	-6.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SCW10 [Source:SGD;Acc:S000004919]
M	YMR304W	UBP15	932	-843.9	4	Ubiquitin-specific protease involved in protein deubiquitination; catalytic activity regulated by an N-terminal TRAF-like domain and and C-terminal sequences; physically interacts with anaphase-promoting complex/cyclosome (APC/C) activator, Cdh1p [Source:SGD;Acc:S000004920]
M	YMR305C	SCW10	780	-209.3	4	Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p [Source:SGD;Acc:S000004921]
M	YMR306C-A	YMR306C-A	10	-2	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004922]
M	YMR306W	FKS3	847	-83	4	Protein involved in spore wall assembly, has similarity to 1,3-beta-D-glucan synthase catalytic subunits Fks1p and Gsc2p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000004923]
M	YMR307C-A	YMR307C-A	1	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GAS1/YMR307W [Source:SGD;Acc:S000028578]
M	YMR307W	GAS1	2678	-569.3	4	Beta-1,3-glucanosyltransferase, required for cell wall assembly and also has a role in transcriptional silencing; localizes to the cell surface via a glycosylphosphatidylinositol (GPI) anchor; also found at the nuclear periphery [Source:SGD;Acc:S000004924]
M	YMR308C	PSE1	1892	-728.2	4	Karyopherin/importin that interacts with the nuclear pore complex; acts as the nuclear import receptor for specific proteins, including Pdr1p, Yap1p, Ste12p, and Aft1p [Source:SGD;Acc:S000004925]
M	YMR309C	NIP1	2972	-1004.4	4	eIF3c subunit of the eukaryotic translation initiation factor 3 (eIF3), involved in the assembly of preinitiation complex and start codon selection [Source:SGD;Acc:S000004926]
M	YMR310C	YMR310C	401	-136	4	Putative S-adenosylmethionine-dependent methyltransferase; predicted to be involved in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR310C is not an essential gene [Source:SGD;Acc:S000004927]
M	YMR311C	GLC8	1080	-223.2	4	Regulatory subunit of protein phosphatase 1 (Glc7p), involved in glycogen metabolism and chromosome segregation; proposed to regulate Glc7p activity via conformational alteration; ortholog of the mammalian protein phosphatase inhibitor 2 [Source:SGD;Acc:S000004928]
M	YMR312W	ELP6	261	-83.9	4	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity [Source:SGD;Acc:S000004929]
M	YMR313C	TGL3	321	-264.3	4	Bifunctional enzyme with triacylglycerol lipase and lysophosphatidylethanolamine acyltransferase activity; responsible for all the triacylglycerol lipase activity of the lipid particle; required with Tgl4p for timely bud formation [Source:SGD;Acc:S000004930]
M	YMR314W	PRE5	2550	-403.9	4	Alpha 6 subunit of the 20S proteasome [Source:SGD;Acc:S000004931]
M	YMR315W	YMR315W	1966	-550.7	4	Protein with NADP(H) oxidoreductase activity; transcription is regulated by Stb5p in response to NADPH depletion induced by diamide; promoter contains a putative Stb5p binding site [Source:SGD;Acc:S000004932]
M	YMR315W-A	YMR315W-A	3	-4.3	2	Putative protein of unknown function [Source:SGD;Acc:S000028697]
M	YMR316C-A	YMR316C-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene DIA1/YMR316W [Source:SGD;Acc:S000004933]
M	YMR316C-B	YMR316C-B	1	-1.2	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004934]
M	YMR316W	DIA1	141	-92.8	4	Protein of unknown function, involved in invasive and pseudohyphal growth; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000004935]
M	YMR317W	YMR317W	19	-12.3	2	Putative protein of unknown function with some similarity to sialidase from Trypanosoma; YMR317W is not an essential gene [Source:SGD;Acc:S000004936]
M	YMR318C	ADH6	2177	-543.8	4	NADPH-dependent medium chain alcohol dehydrogenase with broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance [Source:SGD;Acc:S000004937]
M	YMR319C	FET4	224	-115.2	4	Low-affinity Fe(II) transporter of the plasma membrane [Source:SGD;Acc:S000004938]
M	YMR320W	YMR320W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004939]
M	YMR321C	YMR321C	621	-83	4	Putative protein of unknown function; proposed to be a palmitoylated membrane protein [Source:SGD;Acc:S000004940]
M	YMR322C	SNO4	126	-133.9	4	Possible chaperone and cysteine protease, similar to bacterial Hsp31 and yeast Hsp31p, Hsp32p, and Hsp33p; DJ-1/ThiJ/PfpI superfamily member; predicted involvement in pyridoxine metabolism; induced by mild heat stress and copper deprivation [Source:SGD;Acc:S000004941]
M	YMR323W	ERR3	395	-432	4	Protein of unknown function, has similarity to enolases [Source:SGD;Acc:S000004942]
M	YMR324C	YMR324C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; transcription is AZF1 dependent in glycerol-lactate medium and SLT2 dependent in response to the lipid hydroperoxides [Source:SGD;Acc:S000004943]
M	YMR325W	PAU19	12	-9.3	2	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions [Source:SGD;Acc:S000004944]
M	YMR326C	YMR326C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the telomere on the right arm of chromosome 13 [Source:SGD;Acc:S000004945]
N	YNL001W	DOM34	637	-692.9	4	Protein that, with binding partner Hbs1p, facilitates ribosomal subunit dissociation when translation is stalled; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog [Source:SGD;Acc:S000004946]
N	YNL002C	RLP7	1464	-171.9	4	Nucleolar protein with similarity to large ribosomal subunit L7 proteins; constituent of 66S pre-ribosomal particles; plays an essential role in processing of precursors to the large ribosomal subunit RNAs [Source:SGD;Acc:S000004947]
N	YNL003C	PET8	124	-114.2	4	S-adenosylmethionine transporter of the mitochondrial inner membrane, member of the mitochondrial carrier family; required for biotin biosynthesis and respiratory growth [Source:SGD;Acc:S000004948]
N	YNL004W	HRB1	1045	-295.7	4	Poly(A+) RNA-binding protein, involved in the export of mRNAs from the nucleus to the cytoplasm; similar to Gbp2p and Npl3p [Source:SGD;Acc:S000004949]
N	YNL005C	MRP7	568	-264.7	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000004950]
N	YNL006W	LST8	457	-124	4	Protein required for the transport of amino acid permease Gap1p from the Golgi to the cell surface; component of the TOR signaling pathway; associates with both Tor1p and Tor2p; contains a WD-repeat [Source:SGD;Acc:S000004951]
N	YNL007C	SIS1	2838	-531	4	Type II HSP40 co-chaperone that interacts with the HSP70 protein Ssa1p; not functionally redundant with Ydj1p due to due to substrate specificity; shares similarity with bacterial DnaJ proteins [Source:SGD;Acc:S000004952]
N	YNL008C	ASI3	127	-120.6	4	Putative integral membrane E3 ubiquitin ligase; acts with Asi1p and Asi2p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals [Source:SGD;Acc:S000004953]
N	YNL009W	IDP3	1859	-444.6	4	Peroxisomal NADP-dependent isocitrate dehydrogenase, catalyzes oxidation of isocitrate to alpha-ketoglutarate with the formation of NADP(H+), required for growth on unsaturated fatty acids [Source:SGD;Acc:S000004954]
N	YNL010W	YNL010W	2021	-501.1	4	Putative protein of unknown function with similarity to phosphoserine phosphatases; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; homozygous diploid mutant shows an increase in glycogen accumulation [Source:SGD;Acc:S000004955]
N	YNL011C	YNL011C	128	-182.5	4	Putative protein of unknown function; YNL011C is not an essential gene [Source:SGD;Acc:S000004956]
N	YNL012W	SPO1	29	-10.2	2	Meiosis-specific prospore protein; required for meiotic spindle pole body duplication and separation; required to produce bending force necessary for proper prospore membrane assembly during sporulation; has similarity to phospholipase B [Source:SGD;Acc:S000004957]
N	YNL013C	YNL013C	2	-1.8	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W [Source:SGD;Acc:S000004958]
N	YNL014W	HEF3	4451	-1214.3	4	Translational elongation factor EF-3; paralog of YEF3 and member of the ABC superfamily; stimulates EF-1 alpha-dependent binding of aminoacyl-tRNA by the ribosome; normally expressed in zinc deficient cells [Source:SGD;Acc:S000004959]
N	YNL015W	PBI2	1480	-212.3	4	Cytosolic inhibitor of vacuolar proteinase B (PRB1), required for efficient vacuole inheritance; with thioredoxin forms protein complex LMA1, which assists in priming SNARE molecules and promotes vacuole fusion [Source:SGD;Acc:S000004960]
N	YNL016W	PUB1	2217	-604	4	Poly (A)+ RNA-binding protein, abundant mRNP-component protein that binds mRNA and is required for stability of many mRNAs; component of glucose deprivation induced stress granules, involved in P-body-dependent granule assembly [Source:SGD;Acc:S000004961]
N	YNL017C	YNL017C	4	-1.5	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the tRNA ORF tI(AAU)N2 [Source:SGD;Acc:S000004962]
N	YNL018C	YNL018C	11	-10.9	2	Putative protein of unknown function [Source:SGD;Acc:S000004963]
N	YNL019C	YNL019C	6	-2.8	2	Putative protein of unknown function [Source:SGD;Acc:S000004964]
N	YNL020C	ARK1	292	-904.8	4	Serine/threonine protein kinase involved in regulation of the cortical actin cytoskeleton; involved in control of endocytosis [Source:SGD;Acc:S000004965]
N	YNL021W	HDA1	502	-382.4	4	Putative catalytic subunit of a class II histone deacetylase complex that also contains Hda2p and Hda3p; Hda1p interacts with the Hda2p-Hda3p subcomplex to form an active tetramer; deletion increases histone H2B, H3 and H4 acetylation [Source:SGD;Acc:S000004966]
N	YNL022C	RCM1	586	-274.3	4	Putative cytosine 5-methyltransferase, contains seven beta-strand methyltransferase motif similar to NOP2/YNL061W; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; predicted to be involved in ribosome biogenesis [Source:SGD;Acc:S000004967]
N	YNL023C	FAP1	438	-286.3	4	Protein that binds to Fpr1p, conferring rapamycin resistance by competing with rapamycin for Fpr1p binding; accumulates in the nucleus upon treatment of cells with rapamycin; has similarity to D. melanogaster shuttle craft and human NFX1 [Source:SGD;Acc:S000004968]
N	YNL024C	YNL024C	20	-26.6	4	Putative protein of unknown function with seven beta-strand methyltransferase motif; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL024C is not an essential gene [Source:SGD;Acc:S000004969]
N	YNL024C-A	KSH1	116	-31.9	4	Essential protein suggested to function early in the secretory pathway; inviability is suppressed by overexpression of Golgi protein Tvp23p; ortholog of human Kish [Source:SGD;Acc:S000028698]
N	YNL025C	SSN8	31	-493.9	4	Cyclin-like component of the RNA polymerase II holoenzyme, involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression and telomere maintenance [Source:SGD;Acc:S000004970]
N	YNL026W	SAM50	413	-365.7	4	Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85 [Source:SGD;Acc:S000004971]
N	YNL027W	CRZ1	489	-362	4	Transcription factor that activates transcription of genes involved in stress response; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation [Source:SGD;Acc:S000004972]
N	YNL028W	YNL028W	1	0	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000004973]
N	YNL029C	KTR5	25	-71	4	Putative mannosyltransferase involved in protein glycosylation; member of the KRE2/MNT1 mannosyltransferase family [Source:SGD;Acc:S000004974]
N	YNL030W	HHF2	3472	-385.3	4	Histone H4, core histone protein required for chromatin assembly and chromosome function; one of two identical histone proteins (see also HHF1); contributes to telomeric silencing; N-terminal domain involved in maintaining genomic integrity [Source:SGD;Acc:S000004975]
N	YNL031C	HHT2	1860	-246.2	4	Histone H3, core histone protein required for chromatin assembly, part of heterochromatin-mediated telomeric and HM silencing; one of two identical histone H3 proteins (see HHT1); regulated by acetylation, methylation, and phosphorylation [Source:SGD;Acc:S000004976]
N	YNL032W	SIW14	240	-155	4	Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm [Source:SGD;Acc:S000004977]
N	YNL033W	YNL033W	6	-2.8	2	Putative protein of unknown function [Source:SGD;Acc:S000004978]
N	YNL034W	YNL034W	63	-9.1	2	Putative protein of unknown function; YNL034W is not an essential gene [Source:SGD;Acc:S000004979]
N	YNL035C	YNL035C	851	-366.6	4	Putative protein of unknown function with similarity to proteins containing WD-40 domains; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YNL035C is not an essential gene [Source:SGD;Acc:S000004980]
N	YNL036W	NCE103	621	-287	4	Carbonic anhydrase; metalloenzyme that catalyzes CO2 hydration to bicarbonate and protons; poorly transcribed under aerobic conditions and at an undetectable level under anaerobic conditions; involved in non-classical protein export pathway [Source:SGD;Acc:S000004981]
N	YNL037C	IDH1	2778	-589.5	4	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle [Source:SGD;Acc:S000004982]
N	YNL038W	GPI15	17	-46.2	4	Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-H protein [Source:SGD;Acc:S000004983]
N	YNL039W	BDP1	523	-342.3	4	Essential subunit of RNA polymerase III transcription factor (TFIIIB), which is involved in transcription of genes encoding tRNAs, 5S rRNA, U6 snRNA, and other small RNAs [Source:SGD;Acc:S000004984]
N	YNL040W	YNL040W	467	-225.3	4	Putative protein of unknown function with strong similarity to alanyl-tRNA synthases from Eubacteria; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL040W is not an essential gene [Source:SGD;Acc:S000004985]
N	YNL041C	COG6	677	-387.4	4	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000004986]
N	YNL042W	BOP3	144	-77.4	4	Protein of unknown function, potential Cdc28p substrate; overproduction confers resistance to methylmercury [Source:SGD;Acc:S000004987]
N	YNL042W-B	YNL042W-B	1	-2.3	2	Putative protein of unknown function [Source:SGD;Acc:S000028850]
N	YNL043C	YNL043C	1	0	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YIP3/YNL044W [Source:SGD;Acc:S000004988]
N	YNL044W	YIP3	1255	-202.9	4	Protein localized to COPII vesicles, proposed to be involved in ER to Golgi transport; interacts with members of the Rab GTPase family and Yip1p; also interacts with Rtn1p [Source:SGD;Acc:S000004989]
N	YNL045W	LAP2	1338	-813.9	4	Leucyl aminopeptidase yscIV (leukotriene A4 hydrolase) with epoxide hydrolase activity, metalloenzyme containing one zinc atom; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000004990]
N	YNL046W	YNL046W	23	-39.7	4	Putative protein of unknown function; expression depends on Swi5p; GFP-fusion protein localizes to the endoplasmic reticulum; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) [Source:SGD;Acc:S000004991]
N	YNL047C	SLM2	277	-199.8	4	Phosphoinositide PI4,5P(2) binding protein, forms a complex with Slm1p; acts downstream of Mss4p in a pathway regulating actin cytoskeleton organization in response to stress; phosphorylated by the TORC2 complex [Source:SGD;Acc:S000004992]
N	YNL048W	ALG11	472	-265.5	4	Alpha-1,2-mannosyltransferase, catalyzes sequential addition of the two terminal alpha 1,2-mannose residues to the Man5GlcNAc2-PP-dolichol intermediate during asparagine-linked glycosylation in the ER [Source:SGD;Acc:S000004993]
N	YNL049C	SFB2	1129	-512.1	4	Component of the Sec23p-Sfb2p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb3p [Source:SGD;Acc:S000004994]
N	YNL050C	YNL050C	359	-175.1	4	Putative protein of unknown function; YNL050c is not an essential gene [Source:SGD;Acc:S000004995]
N	YNL051W	COG5	239	-215.8	4	Component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000004996]
N	YNL052W	COX5A	1010	-309.2	4	Subunit Va of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; predominantly expressed during aerobic growth while its isoform Vb (Cox5Bp) is expressed during anaerobic growth [Source:SGD;Acc:S000004997]
N	YNL053W	MSG5	143	-747.8	4	Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p [Source:SGD;Acc:S000004998]
N	YNL054W	VAC7	391	-172.5	4	Integral vacuolar membrane protein involved in vacuole inheritance and morphology; activates Fab1p kinase activity under basal conditions and also after hyperosmotic shock [Source:SGD;Acc:S000004999]
N	YNL054W-A	YNL054W-A	4539	-1579	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007384]
N	YNL055C	POR1	3980	-1144	4	Mitochondrial porin (voltage-dependent anion channel), outer membrane protein required for the maintenance of mitochondrial osmotic stability and mitochondrial membrane permeability; phosphorylated [Source:SGD;Acc:S000005000]
N	YNL056W	OCA2	118	-81.4	4	Putative protein with similarity to predicted tyrosine phosphatases Oca1p and Siw14p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YNL056W is not an essential gene [Source:SGD;Acc:S000005001]
N	YNL057W	YNL057W	6	-2.6	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005002]
N	YNL058C	YNL058C	262	-62.4	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YNL058C is not an essential gene [Source:SGD;Acc:S000005003]
N	YNL059C	ARP5	988	-1630.9	4	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes [Source:SGD;Acc:S000005004]
N	YNL061W	NOP2	2143	-586.3	4	Probable RNA m(5)C methyltransferase, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; localized to the nucleolus; constituent of 66S pre-ribosomal particles [Source:SGD;Acc:S000005005]
N	YNL062C	GCD10	570	-271	4	Subunit of tRNA (1-methyladenosine) methyltransferase with Gcd14p, required for the modification of the adenine at position 58 in tRNAs, especially tRNAi-Met; first identified as a negative regulator of GCN4 expression [Source:SGD;Acc:S000005006]
N	YNL063W	MTQ1	20	-58.9	4	S-adenosylmethionine-dependent methyltransferase; methylates translational release factor Mrf1p; similar to E.coli PrmC; is not an essential gene [Source:SGD;Acc:S000005007]
N	YNL064C	YDJ1	3740	-583	4	Type I HSP40 co-chaperone involved in regulation of the HSP90 and HSP70 functions; involved in protein translocation across membranes; member of the DnaJ family [Source:SGD;Acc:S000005008]
N	YNL065W	AQR1	83	-41.1	4	Plasma membrane multidrug transporter of the major facilitator superfamily, confers resistance to short-chain monocarboxylic acids and quinidine; involved in the excretion of excess amino acids [Source:SGD;Acc:S000005009]
N	YNL066W	SUN4	469	-144.6	4	Cell wall protein related to glucanases, possibly involved in cell wall septation; member of the SUN family [Source:SGD;Acc:S000005010]
N	YNL067W	RPL9B	4261	-586.2	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl9Ap and has similarity to E. coli L6 and rat L9 ribosomal proteins [Source:SGD;Acc:S000005011]
N	YNL067W-A	YNL067W-A	2	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007623]
N	YNL067W-B	YNL067W-B	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000028810]
N	YNL068C	FKH2	527	-219.3	4	Forkhead family transcription factor with a major role in the expression of G2/M phase genes; positively regulates transcriptional elongation; negative role in chromatin silencing at HML and HMR; substrate of the Cdc28p/Clb5p kinase [Source:SGD;Acc:S000005012]
N	YNL069C	RPL16B	4257	-527.5	4	N-terminally acetylated protein component of the large (60S) ribosomal subunit, binds to 5.8 S rRNA; has similarity to Rpl16Ap, E. coli L13 and rat L13a ribosomal proteins; transcriptionally regulated by Rap1p [Source:SGD;Acc:S000005013]
N	YNL070W	TOM7	607	-71.5	4	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex [Source:SGD;Acc:S000005014]
N	YNL071W	LAT1	2858	-966.2	4	Dihydrolipoamide acetyltransferase component (E2) of pyruvate dehydrogenase complex, which catalyzes the oxidative decarboxylation of pyruvate to acetyl-CoA [Source:SGD;Acc:S000005015]
N	YNL072W	RNH201	180	-110.7	4	Ribonuclease H2 catalytic subunit, removes RNA primers during Okazaki fragment synthesis and errant ribonucleotides misincorporated during DNA replication; homolog of RNAse HI; related to human AGS4 which causes Aicardi-Goutieres syndrome [Source:SGD;Acc:S000005016]
N	YNL073W	MSK1	235	-372.7	4	Mitochondrial lysine-tRNA synthetase, required for import of both aminoacylated and deacylated forms of tRNA(Lys) into mitochondria and for aminoacylation of mitochondrially encoded tRNA(Lys) [Source:SGD;Acc:S000005017]
N	YNL074C	MLF3	817	-338.3	4	Serine-rich protein of unknown function, predicted to be palmitoylated; overproduction suppresses the growth inhibition caused by exposure to the immunosuppressant leflunomide [Source:SGD;Acc:S000005018]
N	YNL075W	IMP4	994	-181.6	4	Component of the SSU processome, which is required for pre-18S rRNA processing; interacts with Mpp10p; member of a superfamily of proteins that contain a sigma(70)-like motif and associate with RNAs [Source:SGD;Acc:S000005019]
N	YNL076W	MKS1	594	-1171	4	Pleiotropic negative transcriptional regulator involved in Ras-CAMP and lysine biosynthetic pathways and nitrogen regulation; involved in retrograde (RTG) mitochondria-to-nucleus signaling [Source:SGD;Acc:S000005020]
N	YNL077W	APJ1	265	-108.7	4	Putative chaperone of the HSP40 (DNAJ) family; overexpression interferes with propagation of the [Psi+] prion; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005021]
N	YNL078W	NIS1	103	-54.8	4	Protein localized in the bud neck at G2/M phase; physically interacts with septins; possibly involved in a mitotic signaling network [Source:SGD;Acc:S000005022]
N	YNL079C	TPM1	2330	-643.8	4	Major isoform of tropomyosin; binds to and stabilizes actin cables and filaments, which direct polarized cell growth and the distribution of several organelles; acetylated by the NatB complex and acetylated form binds actin most efficiently [Source:SGD;Acc:S000005023]
N	YNL080C	EOS1	124	-96.2	4	Protein involved in N-glycosylation; deletion mutation confers sensitivity to exidative stress and shows synthetic lethality with mutations in the spindle checkpoint genes BUB3 and MAD1; YNL080C is not an essential gene [Source:SGD;Acc:S000005024]
N	YNL081C	SWS2	109	-62.2	4	Putative mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S13 ribosomal protein; participates in controlling sporulation efficiency [Source:SGD;Acc:S000005025]
N	YNL082W	PMS1	151	-139.3	4	ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL [Source:SGD;Acc:S000005026]
N	YNL083W	SAL1	59	-32.4	3	ADP/ATP transporter; member of the Ca2+-binding subfamily of mitochondrial carriers, with two EF-hand motifs; transport activity of either Sal1p or Pet9p is critical for viability; polymorphic in different S. cerevisiae strains [Source:SGD;Acc:S000005027]
N	YNL084C	END3	1124	-483.3	4	EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p [Source:SGD;Acc:S000005028]
N	YNL085W	MKT1	1293	-441.9	4	Protein that forms a complex with Pbp1p that may mediate posttranscriptional regulation of HO; involved in propagation of M2 dsRNA satellite of L-A virus; allelic variation affects mitochondrial genome stability, drug resistance, and more [Source:SGD;Acc:S000005029]
N	YNL086W	SNN1	38	-46.2	4	Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; green fluorescent protein (GFP)-fusion protein localizes to endosomes [Source:SGD;Acc:S000005030]
N	YNL087W	TCB2	1268	-1123.1	4	Bud-specific protein with a potential role in membrane trafficking; GFP-fusion protein migrates from the cell surface to intracellular vesicles near vacuole; contains 3 calcium and lipid binding domains; mRNA is targeted to the bud [Source:SGD;Acc:S000005031]
N	YNL088W	TOP2	1475	-758.6	4	Topoisomerase II, relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone of both positively and negatively supercoiled DNA; cleaves complementary strands; localizes to axial cores in meiosis [Source:SGD;Acc:S000005032]
N	YNL089C	YNL089C	5	-2.2	2	Dubious open reading frame unlikely to encode a functional protein; almost completely overlaps YNL090W/RHO2 which encodes a small GTPase of the Rho/Rac subfamily of Ras-like proteins [Source:SGD;Acc:S000005033]
N	YNL090W	RHO2	657	-114.6	4	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly [Source:SGD;Acc:S000005034]
N	YNL091W	NST1	495	-365.4	4	Protein of unknown function, mediates sensitivity to salt stress; interacts physically with the splicing factor Msl1p and also displays genetic interaction with MSL1 [Source:SGD;Acc:S000005035]
N	YNL092W	YNL092W	47	-55.4	2	Putative S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; YNL092W is not an essential gene [Source:SGD;Acc:S000005036]
N	YNL093W	YPT53	605	-129	4	Rab family GTPase, similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis [Source:SGD;Acc:S000005037]
N	YNL094W	APP1	86	-98.5	4	Protein of unknown function, interacts with Rvs161p and Rvs167p; computational analysis of protein-protein interactions in large-scale studies suggests a possible role in actin filament organization [Source:SGD;Acc:S000005038]
N	YNL095C	YNL095C	127	-93.5	4	Putative protein of unknown function predicted to contain a transmembrane domain; YNL095C is not an essential gene [Source:SGD;Acc:S000005039]
N	YNL096C	RPS7B	4308	-476.1	4	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Ap; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins [Source:SGD;Acc:S000005040]
N	YNL097C	PHO23	417	-90	4	Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING   its isoform ING3 [Source:SGD;Acc:S000005041]
N	YNL097C-B	YNL097C-B	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000028699]
N	YNL097W-A	YNL097W-A	2	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene PHO23/YNL097C [Source:SGD;Acc:S000028700]
N	YNL098C	RAS2	2318	-474	4	GTP-binding protein that regulates the nitrogen starvation response, sporulation, and filamentous growth; farnesylation and palmitoylation required for activity and localization to plasma membrane; homolog of mammalian Ras proto-oncogenes [Source:SGD;Acc:S000005042]
N	YNL099C	OCA1	408	-934.6	4	Putative protein tyrosine phosphatase, required for cell cycle arrest in response to oxidative damage of DNA [Source:SGD;Acc:S000005043]
N	YNL100W	MIC27	369	-304.3	4	Mitochondrial inner membrane protein; component of the mitochondrial inner membrane organizing system (MitOS, MICOS, or MINOS), a scaffold-like structure on the intermembrane space side of the inner membrane which has a role in the maintenance of cr  unctions and inner membrane architecture [Source:SGD;Acc:S000005044]
N	YNL101W	AVT4	262	-68.3	4	Vacuolar transporter, exports large neutral amino acids from the vacuole; member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters [Source:SGD;Acc:S000005045]
N	YNL102W	POL1	1145	-577.8	4	Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis [Source:SGD;Acc:S000005046]
N	YNL103W	MET4	477	-352.3	4	Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p [Source:SGD;Acc:S000005047]
N	YNL103W-A	YNL103W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MET4/YNL104C [Source:SGD;Acc:S000028701]
N	YNL104C	LEU4	2732	-1540.5	4	Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway [Source:SGD;Acc:S000005048]
N	YNL105W	RRT16	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription [Source:SGD;Acc:S000005049]
N	YNL106C	INP52	564	-284.2	4	Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain [Source:SGD;Acc:S000005050]
N	YNL107W	YAF9	203	-640.5	4	Subunit of both the NuA4 histone H4 acetyltransferase complex and the SWR1 complex, may function to antagonize silencing near telomeres; interacts directly with Swc4p, has homology to human leukemogenic protein AF9, contains a YEATS domain [Source:SGD;Acc:S000005051]
N	YNL108C	YNL108C	694	-146.7	4	Putative protein of unknown function with similarity to Tfc7p and prokaryotic phosphotransfer enzymes; null mutant shows alterations in glucose metabolism; GFP-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000005052]
N	YNL109W	YNL109W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YNL108C [Source:SGD;Acc:S000005053]
N	YNL110C	NOP15	941	-88.9	4	Constituent of 66S pre-ribosomal particles, involved in 60S ribosomal subunit biogenesis; localizes to both nucleolus and cytoplasm [Source:SGD;Acc:S000005054]
N	YNL111C	CYB5	427	-223.7	4	Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation [Source:SGD;Acc:S000005055]
N	YNL112W	DBP2	2930	-595.6	4	Essential ATP-dependent RNA helicase of the DEAD-box protein family, involved in nonsense-mediated mRNA decay and rRNA processing [Source:SGD;Acc:S000005056]
N	YNL113W	RPC19	1957	-220.2	4	RNA polymerase subunit AC19, common to RNA polymerases I and III [Source:SGD;Acc:S000005057]
N	YNL114C	YNL114C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPC19/YNL113W, an RNA polymerase subunit [Source:SGD;Acc:S000005058]
N	YNL115C	YNL115C	886	-395.2	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene [Source:SGD;Acc:S000005059]
N	YNL116W	DMA2	486	-202.2	4	Protein involved in ubiquitination; plays a role in regulating spindle position and orientation; functionally redundant with Dma1p; orthologous to human RNF8 protein, also has sequence similarity to human Chfr [Source:SGD;Acc:S000005060]
N	YNL117W	MLS1	768	-2030.3	4	Malate synthase, enzyme of the glyoxylate cycle, involved in utilization of non-fermentable carbon sources; expression is subject to carbon catabolite repression; localizes in peroxisomes during growth in oleic acid medium [Source:SGD;Acc:S000005061]
N	YNL118C	DCP2	1495	-730.5	4	Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; member of the Nudix hydrolase family [Source:SGD;Acc:S000005062]
N	YNL119W	NCS2	349	-192.5	4	Protein required for thiolation of the uridine at the wobble position of Lys(UUU) and Glu(UUC) tRNAs; has a role in urmylation and in invasive and pseudohyphal growth; inhibits replication of Brome mosaic virus in S. cerevisiae [Source:SGD;Acc:S000005063]
N	YNL120C	YNL120C	5	-4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; deletion enhances replication of Brome mosaic virus in S. cerevisiae, but likely due to effects on the overlapping gene [Source:SGD;Acc:S000005064]
N	YNL121C	TOM70	2558	-1135.5	4	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; acts as a receptor for incoming precursor proteins [Source:SGD;Acc:S000005065]
N	YNL122C	YNL122C	45	-33	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL122C is not an essential gene [Source:SGD;Acc:S000005066]
N	YNL123W	NMA111	1208	-579.1	4	Serine protease and general molecular chaperone; involved in response to heat stress and promotion of apoptosis; may contribute to lipid homeostasis; sequence similarity to the mammalian Omi/HtrA2 family of serine proteases [Source:SGD;Acc:S000005067]
N	YNL124W	NAF1	345	-133.8	4	RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p [Source:SGD;Acc:S000005068]
N	YNL125C	ESBP6	161	-99	4	Protein with similarity to monocarboxylate permeases, appears not to be involved in transport of monocarboxylates such as lactate, pyruvate or acetate across the plasma membrane [Source:SGD;Acc:S000005069]
N	YNL126W	SPC98	192	-227.1	4	Component of the microtubule-nucleating Tub4p (gamma-tubulin) complex; interacts with Spc110p at the spindle pole body (SPB) inner plaque and with Spc72p at the SPB outer plaque [Source:SGD;Acc:S000005070]
N	YNL127W	FAR11	386	-312.9	4	Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far8p, Far9p, and Far10p; has similarity to the N- and C-termini of N. crassa HAM-2 [Source:SGD;Acc:S000005071]
N	YNL128W	TEP1	21	-499.4	4	Homolog of human tumor suppressor gene PTEN/MMAC1/TEP1 that has lipid phosphatase activity and is linked to the phosphatidylinositol signaling pathway; plays a role in normal sporulation [Source:SGD;Acc:S000005072]
N	YNL129W	NRK1	286	-123.6	4	Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis [Source:SGD;Acc:S000005073]
N	YNL130C	CPT1	510	-47.3	4	Cholinephosphotransferase, required for phosphatidylcholine biosynthesis and for inositol-dependent regulation of EPT1 transcription [Source:SGD;Acc:S000005074]
N	YNL130C-A	DGR1	2	-2.3	2	Protein of unknown function; dgr1 null mutant is resistant to 2-deoxy-D-glucose [Source:SGD;Acc:S000028579]
N	YNL131W	TOM22	1670	-249.6	4	Component of the TOM (translocase of outer mitochondrial membrane) complex responsible for initial import of mitochondrially directed proteins; acts as a receptor for precursor proteins and mediates interaction between TOM and TIM complexes [Source:SGD;Acc:S000005075]
N	YNL132W	KRE33	2138	-777.5	4	Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance [Source:SGD;Acc:S000005076]
N	YNL133C	FYV6	174	-98.3	4	Protein of unknown function, required for survival upon exposure to K1 killer toxin; proposed to regulate double-strand break repair via non-homologous end-joining [Source:SGD;Acc:S000005077]
N	YNL134C	YNL134C	2503	-1118.6	4	Putative protein of unknown function with similarity to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus and is induced by the DNA-damaging agent MMS [Source:SGD;Acc:S000005078]
N	YNL135C	FPR1	2684	-244.5	4	Peptidyl-prolyl cis-trans isomerase (PPIase), binds to the drugs FK506 and rapamycin; also binds to the nonhistone chromatin binding protein Hmo1p and may regulate its assembly or function [Source:SGD;Acc:S000005079]
N	YNL136W	EAF7	193	-103.2	4	Subunit of the NuA4 histone acetyltransferase complex, which acetylates the N-terminal tails of histones H4 and H2A [Source:SGD;Acc:S000005080]
N	YNL137C	NAM9	564	-298.8	4	Mitochondrial ribosomal component of the small subunit [Source:SGD;Acc:S000005081]
N	YNL138W	SRV2	2836	-653	4	CAP (cyclase-associated protein) subunit of adenylyl cyclase complex; N-terminus binds adenylyl cyclase and facilitates activation by RAS; C-terminus binds ADP-actin monomers, facilitating regulation of actin dynamics and cell morphogenesis [Source:SGD;Acc:S000005082]
N	YNL138W-A	YSF3	49	-32.2	4	Component of the SF3b subcomplex of the U2 snRNP, essential protein required for for splicing and for assembly of SF3b [Source:SGD;Acc:S000028509]
N	YNL139C	THO2	867	-790.4	4	Subunit of the THO complex, which is required for efficient transcription elongation and involved in transcriptional elongation-associated recombination; required for LacZ RNA expression from certain plasmids [Source:SGD;Acc:S000005083]
N	YNL140C	YNL140C	13	-2.6	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene THO2/YNL139C [Source:SGD;Acc:S000005084]
N	YNL141W	AAH1	1267	-225.7	4	Adenine deaminase (adenine aminohydrolase), converts adenine to hypoxanthine; involved in purine salvage; transcriptionally regulated by nutrient levels and growth phase; Aah1p degraded upon entry into quiescence via SCF and the proteasome [Source:SGD;Acc:S000005085]
N	YNL142W	MEP2	165	-38.4	4	Ammonium permease involved in regulation of pseudohyphal growth; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation [Source:SGD;Acc:S000005086]
N	YNL143C	YNL143C	12	-9.5	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005087]
N	YNL144C	YNL144C	85	-29.3	4	Putative protein of unknown function; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; contains a PH domain and binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study [Source:SGD;Acc:S000005088]
N	YNL144W-A	YNL144W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YNL144C [Source:SGD;Acc:S000028702]
N	YNL145W	MFA2	5	-5.3	2	Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1 [Source:SGD;Acc:S000005089]
N	YNL146C-A	YNL146C-A	1	-2.5	2	Putative protein of unknown function [Source:SGD;Acc:S000028851]
N	YNL146W	YNL146W	7	-6.2	3	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNL146W is not an essential gene [Source:SGD;Acc:S000005090]
N	YNL147W	LSM7	274	-112.3	4	Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA [Source:SGD;Acc:S000005091]
N	YNL148C	ALF1	152	-55.6	4	Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance [Source:SGD;Acc:S000005092]
N	YNL149C	PGA2	866	-199.5	4	Essential protein required for maturation of Gas1p and Pho8p; involved in protein trafficking; GFP-fusion protein localizes to the ER and YFP-fusion protein to the nuclear envelope-ER network; null mutants have a cell separation defect [Source:SGD;Acc:S000005093]
N	YNL150W	YNL150W	6	-2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; extensive overlap with PGA2/YNL149C, an uncharacterized gene with a proposed role in protein trafficking [Source:SGD;Acc:S000005094]
N	YNL151C	RPC31	624	-182.3	4	RNA polymerase III subunit C31 [Source:SGD;Acc:S000005095]
N	YNL152W	INN1	213	-139.6	4	Essential protein that associates with the contractile actomyosin ring, required for ingression of the plasma membrane into the bud neck during cytokinesis; C2 domain, a membrane targeting module, is required for function [Source:SGD;Acc:S000005096]
N	YNL153C	GIM3	932	-128.5	4	Subunit of the heterohexameric cochaperone prefoldin complex which binds specifically to cytosolic chaperonin and transfers target proteins to it [Source:SGD;Acc:S000005097]
N	YNL154C	YCK2	1815	-484.1	4	Palmitoylated plasma membrane-bound casein kinase I isoform; shares redundant functions with Yck1p in morphogenesis, proper septin assembly, endocytic trafficking; provides an essential function overlapping with that of Yck1p [Source:SGD;Acc:S000005098]
N	YNL155W	CUZ1	321	-164.7	4	Putative protein of unknown function; contains a DHHC domain and an AN1-type zinc finger; predicted to have thiol-disulfide oxidoreductase active site; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of hu  RAP, which stimulates proteasome activity in response to arsenic [Source:SGD;Acc:S000005099]
N	YNL156C	NSG2	580	-159	4	Protein involved in regulation of sterol biosynthesis; specifically stabilizes Hmg2p, one of two HMG-CoA isoenzymes that catalyze the rate-limiting step in sterol biosynthesis; homolog of mammalian INSIG proteins [Source:SGD;Acc:S000005100]
N	YNL157W	IGO1	885	-126.8	4	Protein required for initiation of G0 program; prevents degradation of nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway; phosphorylated by Rim15p; GFP protein localizes to the cytoplasm and nucleus; similar to Igo2p [Source:SGD;Acc:S000005101]
N	YNL158W	PGA1	91	-81.3	4	Essential component of GPI-mannosyltransferase II, responsible for second mannose addition to GPI precursors as a partner of Gpi18p; required for maturation of Gas1p and Pho8p; has synthetic genetic interations with secretory pathway genes [Source:SGD;Acc:S000005102]
N	YNL159C	ASI2	57	-33.6	4	Integral inner nuclear membrane protein that acts with Asi1p and Asi3p to ensure the fidelity of SPS-sensor signalling by maintaining the dormant repressed state of gene expression in the absence of inducing signals [Source:SGD;Acc:S000005103]
N	YNL160W	YGP1	1661	-667.2	4	Cell wall-related secretory glycoprotein; induced by nutrient deprivation-associated growth arrest and upon entry into stationary phase; may be involved in adaptation prior to stationary phase entry; has similarity to Sps100p [Source:SGD;Acc:S000005104]
N	YNL161W	CBK1	641	-1340.8	4	Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates   zation and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization [Source:SGD;Acc:S000005105]
N	YNL162W	RPL42A	1508	-94.2	4	Protein component of the large (60S) ribosomal subunit, identical to Rpl42Bp and has similarity to rat L44 ribosomal protein [Source:SGD;Acc:S000005106]
N	YNL162W-A	YNL162W-A	21	-12.7	4	Putative protein of unknown function; identified by homology [Source:SGD;Acc:S000007624]
N	YNL163C	RIA1	893	-644	4	Cytoplasmic GTPase involved in biogenesis of the 60S ribosome; has similarity to translation elongation factor 2 (Eft1p and Eft2p) [Source:SGD;Acc:S000005107]
N	YNL164C	IBD2	179	-69.1	4	Component of the BUB2-dependent spindle checkpoint pathway, interacts with Bfa1p and functions upstream of Bub2p and Bfa1p [Source:SGD;Acc:S000005108]
N	YNL165W	YNL165W	63	-57.8	4	Putative protein of unknown function; YNL165W is not an essential gene [Source:SGD;Acc:S000005109]
N	YNL166C	BNI5	1090	-536.6	4	Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner [Source:SGD;Acc:S000005110]
N	YNL167C	SKO1	476	-299.3	4	Basic leucine zipper transcription factor of the ATF/CREB family; forms a complex with Tup1p and Cyc8p to both activate and repress transcription; cytosolic and nuclear protein involved in osmotic and oxidative stress responses [Source:SGD;Acc:S000005111]
N	YNL168C	FMP41	995	-262.7	4	Putative protein of unknown function; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005112]
N	YNL169C	PSD1	556	-338.4	4	Phosphatidylserine decarboxylase of the mitochondrial inner membrane, converts phosphatidylserine to phosphatidylethanolamine [Source:SGD;Acc:S000005113]
N	YNL170W	YNL170W	8	-2.3	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005114]
N	YNL171C	YNL171C	2	-1.2	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005115]
N	YNL172W	APC1	198	-838.9	4	Largest subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform    of the APC/C, based on structural analysis [Source:SGD;Acc:S000005116]
N	YNL173C	MDG1	1344	-392.1	4	Plasma membrane protein involved in G-protein mediated pheromone signaling pathway; overproduction suppresses bem1 mutations [Source:SGD;Acc:S000005117]
N	YNL174W	YNL174W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene NOP13/YNL175C [Source:SGD;Acc:S000005118]
N	YNL175C	NOP13	1901	-352.8	4	Nucleolar protein found in preribosomal complexes; contains an RNA recognition motif (RRM) [Source:SGD;Acc:S000005119]
N	YNL176C	TDA7	92	-61	4	Cell cycle-regulated gene of unknown function, promoter bound by Fkh2p; null mutant is sensitive to expression of the top1-T722A allele [Source:SGD;Acc:S000005120]
N	YNL177C	MRPL22	587	-196.6	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000005121]
N	YNL178W	RPS3	5724	-934	4	Protein component of the small (40S) ribosomal subunit, has apurinic/apyrimidinic (AP) endonuclease activity; essential for viability; has similarity to E. coli S3 and rat S3 ribosomal proteins [Source:SGD;Acc:S000005122]
N	YNL179C	YNL179C	4	-0.5	1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance [Source:SGD;Acc:S000005123]
N	YNL180C	RHO5	938	-281.6	4	Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, likely involved in protein kinase C (Pkc1p)-dependent signal transduction pathway that controls cell integrity [Source:SGD;Acc:S000005124]
N	YNL181W	YNL181W	489	-344.4	4	Putative oxidoreductase; required for cell viability [Source:SGD;Acc:S000005125]
N	YNL182C	IPI3	1013	-303.1	4	Essential component of the Rix1 complex (Rix1p, Ipi1p, Ipi3p) that is required for processing of ITS2 sequences from 35S pre-rRNA; highly conserved and contains WD40 motifs; Rix1 complex associates with Mdn1p in pre-60S ribosomal particles [Source:SGD;Acc:S000005126]
N	YNL183C	NPR1	913	-2771.7	4	Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p [Source:SGD;Acc:S000005127]
N	YNL184C	YNL184C	3	-12.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005128]
N	YNL185C	MRPL19	550	-106	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000005129]
N	YNL186W	UBP10	810	-399.4	4	Ubiquitin-specific protease that deubiquitinates ubiquitin-protein moieties; may regulate silencing by acting on Sir4p; involved in posttranscriptionally regulating Gap1p and possibly other transporters; primarily located in the nucleus [Source:SGD;Acc:S000005130]
N	YNL187W	SWT21	14	-78.9	3	Protein involved in mRNA splicing; contains a consensus nuclear export signal (NES) sequence similar to the consensus sequence recognized by Crm1p; interacts genetically with Prp40p and Tgs1p; contains WD40 repeats [Source:SGD;Acc:S000005131]
N	YNL188W	KAR1	73	-119.2	4	Essential protein involved in karyogamy during mating and in spindle pole body duplication during mitosis, localizes to the half-bridge of the spindle pole body, interacts with Spc72p during karyogamy, also interacts with Cdc31p [Source:SGD;Acc:S000005132]
N	YNL189W	SRP1	2515	-618.1	4	Karyopherin alpha homolog, forms a dimer with karyopherin beta Kap95p to mediate import of nuclear proteins, binds the nuclear localization signal of the substrate during import; may also play a role in regulation of protein degradation [Source:SGD;Acc:S000005133]
N	YNL190W	YNL190W	13	-25.2	4	Cell wall protein of unknown function; proposed role as a hydrophilin induced by osmotic stress; contains a putative GPI-attachment site [Source:SGD;Acc:S000005134]
N	YNL191W	DUG3	249	-213.6	4	Probable glutamine amidotransferase, forms a complex with Dug1p and Dug2p to degrade glutathione (GSH) and other peptides containing a gamma-glu-X bond in an alternative pathway to GSH degradation by gamma-glutamyl transpeptidase (Ecm38p) [Source:SGD;Acc:S000005135]
N	YNL192W	CHS1	608	-393.8	4	Chitin synthase I, requires activation from zymogenic form in order to catalyze the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for repairing the chitin septum during cytokinesis; transcription activated by mating factor [Source:SGD;Acc:S000005136]
N	YNL193W	YNL193W	255	-221.3	4	Putative protein of unknown function; exhibits a two-hybrid interaction with Yhr151cp in a large-scale analysis [Source:SGD;Acc:S000005137]
N	YNL194C	YNL194C	196	-122.2	4	Integral membrane protein required for sporulation and plasma membrane sphingolipid content; has sequence similarity to SUR7 and FMP45; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000005138]
N	YNL195C	YNL195C	183	-210.6	4	Putative protein of unknown function; shares a promoter with YNL194C; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005139]
N	YNL196C	SLZ1	13	-3.1	2	Sporulation-specific protein with a leucine zipper motif [Source:SGD;Acc:S000005140]
N	YNL197C	WHI3	673	-219	4	RNA binding protein that sequesters CLN3 mRNA in cytoplasmic foci; cytoplasmic retention factor for Cdc28p and associated cyclins; regulates cell fate and dose-dependently regulates the critical cell size required for passage through Start [Source:SGD;Acc:S000005141]
N	YNL198C	YNL198C	1	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005142]
N	YNL199C	GCR2	457	-216.3	4	Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p [Source:SGD;Acc:S000005143]
N	YNL200C	YNL200C	951	-207.3	4	NADHX epimerase; catalyzes isomerization of (R)- and (S)-NADHX; homologous to AIBP in mammals and the N- terminal domain of YjeF in E.coli; enzyme is widespread in eukaryotes, prokaryotes and archaea; the authentic, non-tagged protein is detected in  y purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005144]
N	YNL201C	PSY2	301	-363.9	4	Subunit of protein phosphatase PP4 complex; active complex is composed of catalytic subunit Pph3p and Psy2p, with Psy4p apparently providing additional substrate specificity in some cases; regulates recovery from the DNA damage checkpoint and also t  e conversion- and single-strand annealing-mediated pathways of meiotic double-strand break repair; Pph3p and Psy2p localize to foci on meiotic chromosomes; putative homolog of mammalian R3 [Source:SGD;Acc:S000005145]
N	YNL202W	SPS19	335	-139.4	4	Peroxisomal 2,4-dienoyl-CoA reductase, auxiliary enzyme of fatty acid beta-oxidation; homodimeric enzyme required for growth and sporulation on petroselineate medium; expression induced during late sporulation and in the presence of oleate [Source:SGD;Acc:S000005146]
N	YNL203C	YNL203C	1	-2	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005147]
N	YNL204C	SPS18	7	-8.5	2	Protein of unknown function, contains a putative zinc-binding domain; expressed during sporulation [Source:SGD;Acc:S000005148]
N	YNL205C	YNL205C	1	-1.3	1	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005149]
N	YNL206C	RTT106	731	-235.6	4	Histone chaperone, involved in regulation of chromatin structure in both transcribed and silenced chromosomal regions; affects transcriptional elongation; has a role in regulation of Ty1 transposition [Source:SGD;Acc:S000005150]
N	YNL207W	RIO2	999	-652.7	4	Essential serine kinase involved in the processing of the 20S pre-rRNA into mature 18S rRNA; has similarity to Rio1p [Source:SGD;Acc:S000005151]
N	YNL208W	YNL208W	2544	-685.7	4	Protein of unknown function; may interact with ribosomes, based on co-purification experiments; authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; potential orthologs found in other fungi [Source:SGD;Acc:S000005152]
N	YNL209W	SSB2	6869	-2870.5	4	Cytoplasmic ATPase that is a ribosome-associated molecular chaperone, functions with J-protein partner Zuo1p; may be involved in the folding of newly-synthesized polypeptide chains; member of the HSP70 family; homolog of SSB1 [Source:SGD;Acc:S000005153]
N	YNL210W	MER1	8	-13.9	2	Protein with RNA-binding motifs required for meiosis-specific mRNA splicing; required for chromosome pairing and meiotic recombination; Mer1p regulon embraces four essential meiotic pre-mRNAs: REC107, HFM1, AMA1 and SPO22 [Source:SGD;Acc:S000005154]
N	YNL211C	YNL211C	18	-52.3	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL211C is not an essential gene [Source:SGD;Acc:S000005155]
N	YNL212W	VID27	964	-528.3	4	Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth [Source:SGD;Acc:S000005156]
N	YNL213C	RRG9	47	-74.6	4	Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005157]
N	YNL214W	PEX17	199	-319.5	4	Peroxisomal membrane peroxin and subunit of the docking complex that facilitates the import of peroxisomal matrix proteins; required for peroxisome biogenesis [Source:SGD;Acc:S000005158]
N	YNL215W	IES2	307	-820.4	4	Protein that associates with the INO80 chromatin remodeling complex under low-salt conditions; essential for growth under anaerobic conditions [Source:SGD;Acc:S000005159]
N	YNL216W	RAP1	1494	-747.6	4	DNA-binding protein involved in either activation or repression of transcription, depending on binding site context; also binds telomere sequences and plays a role in telomeric position effect (silencing) and telomere structure [Source:SGD;Acc:S000005160]
N	YNL217W	YNL217W	130	-335.7	4	Putative protein of unknown function; weak sequence similarity to bis (5'-nucleotidyl)-tetraphosphatases; (GFP)-fusion protein localizes to the vacuole; null mutant is highly sensitive to azaserine and resistant to sodium-O-vandate [Source:SGD;Acc:S000005161]
N	YNL218W	MGS1	138	-228.1	4	Protein with DNA-dependent ATPase and ssDNA annealing activities involved in maintenance of genome; interacts functionally with DNA polymerase delta; homolog of human Werner helicase interacting protein (WHIP) [Source:SGD;Acc:S000005162]
N	YNL219C	ALG9	882	-187.7	4	Mannosyltransferase, involved in N-linked glycosylation; catalyzes the transfer of mannose from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation [Source:SGD;Acc:S000005163]
N	YNL220W	ADE12	2273	-796.9	4	Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence [Source:SGD;Acc:S000005164]
N	YNL221C	POP1	365	-222.3	4	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs; binds to the RPR1 RNA subunit in RNase P [Source:SGD;Acc:S000005165]
N	YNL222W	SSU72	526	-757.9	4	Transcription/RNA-processing factor that associates with TFIIB and cleavage/polyadenylation factor Pta1p; exhibits phosphatase activity on serine-5 of the RNA polymerase II C-terminal domain; affects start site selection in vivo [Source:SGD;Acc:S000005166]
N	YNL223W	ATG4	241	-128.4	4	Conserved cysteine protease required for autophagy; cleaves Atg8p to a form required for autophagosome and Cvt vesicle generation [Source:SGD;Acc:S000005167]
N	YNL224C	SQS1	502	-192.1	4	Stimulates the ATPase and helicase activities of Prp43p; acts with Prp43p to stimulate 18s rRNA maturation by Nob1p; overexpression antagonizes the suppression of splicing defects by spp382 mutants; component of pre-ribosomal particles [Source:SGD;Acc:S000005168]
N	YNL225C	CNM67	415	-298.4	4	Component of the spindle pole body outer plaque; required for spindle orientation and mitotic nuclear migration [Source:SGD;Acc:S000005169]
N	YNL226W	YNL226W	3	-4.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene JJJ1/YNL227C [Source:SGD;Acc:S000005170]
N	YNL227C	JJJ1	316	-148	4	Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis [Source:SGD;Acc:S000005171]
N	YNL228W	YNL228W	6	-2.3	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; almost completely overlaps ORF YNL227C/JJJ1 [Source:SGD;Acc:S000005172]
N	YNL229C	URE2	790	-325.9	4	Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion [Source:SGD;Acc:S000005173]
N	YNL230C	ELA1	78	-201.7	4	Elongin A; F-box protein that forms a heterodimer with Elc1p and is required for ubiquitin-dependent degradation of the RNA Polymerase II subunit Rpo21p; subunit of the Elongin-Cullin-Socs (ECS) ligase complex [Source:SGD;Acc:S000005174]
N	YNL231C	PDR16	1323	-514.7	4	Phosphatidylinositol transfer protein (PITP) controlled by the multiple drug resistance regulator Pdr1p, localizes to lipid particles and microsomes, controls levels of various lipids, may regulate lipid synthesis, homologous to Pdr17p [Source:SGD;Acc:S000005175]
N	YNL232W	CSL4	770	-433.4	4	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain an S1 RNA binding domain; has similarity to human hCsl4p (EXOSC1) [Source:SGD;Acc:S000005176]
N	YNL233W	BNI4	554	-564.6	4	Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p [Source:SGD;Acc:S000005177]
N	YNL234W	YNL234W	122	-68.8	4	Protein of unknown function with similarity to globins; has a functional heme-binding domain; mutant has aneuploidy tolerance; transcription induced by stress conditions; may be involved in glucose signaling or metabolism; regulated by Rgt1 [Source:SGD;Acc:S000005178]
N	YNL235C	YNL235C	2	-2.5	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SIN4/YNL236W, a subunit of the mediator complex [Source:SGD;Acc:S000005179]
N	YNL236W	SIN4	474	-433.4	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; contributes to both postive and negative transcriptional regulation; dispensible for basal transcription [Source:SGD;Acc:S000005180]
N	YNL237W	YTP1	20	-26.7	4	Probable type-III integral membrane protein of unknown function, has regions of similarity to mitochondrial electron transport proteins [Source:SGD;Acc:S000005181]
N	YNL238W	KEX2	159	-162.2	4	Subtilisin-like protease (proprotein convertase), a calcium-dependent serine protease involved in the activation of proproteins of the secretory pathway [Source:SGD;Acc:S000005182]
N	YNL239W	LAP3	1894	-923.2	4	Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH [Source:SGD;Acc:S000005183]
N	YNL240C	NAR1	320	-231	4	Component of the cytosolic iron-sulfur (FeS) protein assembly machinery, required for maturation of cytosolic and nuclear FeS proteins and for normal resistance to oxidative stress; homologous to human Narf [Source:SGD;Acc:S000005184]
N	YNL241C	ZWF1	2279	-932.8	4	Glucose-6-phosphate dehydrogenase (G6PD), catalyzes the first step of the pentose phosphate pathway; involved in adapting to oxidatve stress; homolog of the human G6PD which is deficient in patients with hemolytic anemia [Source:SGD;Acc:S000005185]
N	YNL242W	ATG2	267	-414.6	4	Peripheral membrane protein required for vesicle formation during autophagy, pexophagy, and the cytoplasm-to-vaucole targeting (Cvt) pathway; involved in Atg9p cycling between the phagophore assembly site and mitochondria [Source:SGD;Acc:S000005186]
N	YNL243W	SLA2	2161	-1197.7	4	Transmembrane actin-binding protein involved in membrane cytoskeleton assembly and cell polarization; adaptor protein that links actin to clathrin and endocytosis; present in the actin cortical patch of the emerging bud tip; dimer in vivo [Source:SGD;Acc:S000005187]
N	YNL244C	SUI1	2161	-272.4	4	Translation initiation factor eIF1; component of a complex involved in recognition of the initiator codon; modulates translation accuracy at the initiation phase [Source:SGD;Acc:S000005188]
N	YNL245C	CWC25	192	-128.3	4	Splicing factor required for the first step of pre-mRNA splicing; binding to the spliceosome requires Prp2p and Yju2p; heat-stable protein; has similarity to S. pombe Cwf25p [Source:SGD;Acc:S000005189]
N	YNL246W	VPS75	455	-118.8	4	NAP family histone chaperone; binds to histones and Rtt109p, stimulating histone acetyltransferase activity; possesses nucleosome assembly activity in vitro; proposed role in vacuolar protein sorting and in double-strand break repair [Source:SGD;Acc:S000005190]
N	YNL247W	YNL247W	2321	-1361	4	Cysteinyl-tRNA synthetase; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000005191]
N	YNL248C	RPA49	1671	-560.7	4	RNA polymerase I subunit A49 [Source:SGD;Acc:S000005192]
N	YNL249C	MPA43	130	-154.8	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005193]
N	YNL250W	RAD50	417	-463.4	4	Subunit of MRX complex, with Mre11p and Xrs2p, involved in processing double-strand DNA breaks in vegetative cells, initiation of meiotic DSBs, telomere maintenance, and nonhomologous end joining [Source:SGD;Acc:S000005194]
N	YNL251C	NRD1	1111	-364.8	4	RNA-binding protein, subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); complex mediates termination of snoRNAs and cryptic unstable transcripts (CUTs); interacts with the C-terminal domain of the RNA polymerase II large subunit (Rpo21p), preferentially a  phorylated Ser5; H3K4 trimethylation of transcribed regions by Set1p enhances recruitment of Nrd1p to those sites; required for 3' end maturation of nonpolyadenylated RNAs [Source:SGD;Acc:S000005195]
N	YNL252C	MRPL17	583	-177.7	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000005196]
N	YNL253W	TEX1	202	-89.7	4	Protein involved in mRNA export, component of the transcription export (TREX) complex [Source:SGD;Acc:S000005197]
N	YNL254C	RTC4	78	-38.6	4	Protein of unknown function; null mutation suppresses cdc13-1 temperature sensitivity; (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000005198]
N	YNL255C	GIS2	1469	-280.1	4	Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2 [Source:SGD;Acc:S000005199]
N	YNL256W	FOL1	579	-322.8	4	Multifunctional enzyme of the folic acid biosynthesis pathway, has dihydropteroate synthetase, dihydro-6-hydroxymethylpterin pyrophosphokinase, and dihydroneopterin aldolase activities [Source:SGD;Acc:S000005200]
N	YNL257C	SIP3	132	-241	4	Protein that activates transcription through interaction with DNA-bound Snf1p, C-terminal region has a putative leucine zipper motif; potential Cdc28p substrate [Source:SGD;Acc:S000005201]
N	YNL258C	DSL1	437	-415.3	4	Peripheral membrane protein needed for Golgi-to-ER retrograde traffic; forms a complex with Sec39p and Tip20p that interacts with ER SNAREs Sec20p and Use1p; component of the ER target site that interacts with coatomer; interacts with Cin5p [Source:SGD;Acc:S000005202]
N	YNL259C	ATX1	396	-86.8	4	Cytosolic copper metallochaperone that transports copper to the secretory vesicle copper transporter Ccc2p for eventual insertion into Fet3p, which is a multicopper oxidase required for high-affinity iron uptake [Source:SGD;Acc:S000005203]
N	YNL260C	LTO1	126	-64.7	4	Putative protein of unknown function with similarity to a human protein overexpressed in oral cancers; essential gene with defects in anaerobic and filamentous growth; localizes to the nucleus and cytoplasm [Source:SGD;Acc:S000005204]
N	YNL261W	ORC5	158	-179.1	4	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing [Source:SGD;Acc:S000005205]
N	YNL262W	POL2	873	-911.3	4	Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p [Source:SGD;Acc:S000005206]
N	YNL263C	YIF1	499	-181.5	4	Integral membrane protein required for the fusion of ER-derived COPII transport vesicles with the Golgi; interacts with Yip1p and Yos1p; localizes to the Golgi, the ER, and COPII vesicles; homolog of human YIPF3 [Source:SGD;Acc:S000005207]
N	YNL264C	PDR17	504	-248.7	4	Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition [Source:SGD;Acc:S000005208]
N	YNL265C	IST1	388	-150.2	4	Protein with a positive role in the multivesicular body sorting pathway; functions and forms a complex with Did2p; recruitment to endosomes is mediated by the Vps2p-Vps24p subcomplex of ESCRT-III; also interacts with Vps4p [Source:SGD;Acc:S000005209]
N	YNL266W	YNL266W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF IST1/YNL265C [Source:SGD;Acc:S000005210]
N	YNL267W	PIK1	829	-2303	4	Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton [Source:SGD;Acc:S000005211]
N	YNL268W	LYP1	455	-126	4	Lysine permease; one of three amino acid permeases (Alp1p, Can1p, Lyp1p) responsible for uptake of cationic amino acids [Source:SGD;Acc:S000005212]
N	YNL269W	BSC4	2	-2.4	2	Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression; readthrough is increased upon depletion of Sup35p [Source:SGD;Acc:S000005213]
N	YNL270C	ALP1	64	-17.9	4	Arginine transporter; expression is normally very low and it is unclear what conditions would induce significant expression [Source:SGD;Acc:S000005214]
N	YNL271C	BNI1	994	-882.2	4	Formin, nucleates the formation of linear actin filaments, involved in cell processes such as budding and mitotic spindle orientation which require the formation of polarized actin cables, functionally redundant with BNR1 [Source:SGD;Acc:S000005215]
N	YNL272C	SEC2	709	-515.1	4	Guanyl-nucleotide exchange factor for the small G-protein Sec4p; essential for post-Golgi vesicle transport and for autophagy; associates with the exocyst, via exocyst subunit Sec15p, on secretory vesicles [Source:SGD;Acc:S000005216]
N	YNL273W	TOF1	378	-296	4	Subunit of a replication-pausing checkpoint complex (Tof1p-Mrc1p-Csm3p) that acts at the stalled replication fork to promote sister chromatid cohesion after DNA damage, facilitating gap repair of damaged DNA; interacts with the MCM helicase [Source:SGD;Acc:S000005217]
N	YNL274C	GOR1	1043	-426.3	4	Glyoxylate reductase; null mutation results in increased biomass after diauxic shift; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005218]
N	YNL275W	BOR1	41	-41	4	Boron efflux transporter of the plasma membrane; binds HCO3-, I-, Br-, NO3- and Cl-; has similarity to the characterized boron efflux transporter A. thaliana BOR1 [Source:SGD;Acc:S000005219]
N	YNL276C	YNL276C	4	-6.9	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene MET2/YNL277W [Source:SGD;Acc:S000005220]
N	YNL277W	MET2	232	-174.2	4	L-homoserine-O-acetyltransferase, catalyzes the conversion of homoserine to O-acetyl homoserine which is the first step of the methionine biosynthetic pathway [Source:SGD;Acc:S000005221]
N	YNL277W-A	YNL277W-A	3	-2.1	2	Putative protein of unknown function [Source:SGD;Acc:S000028852]
N	YNL278W	CAF120	540	-311.6	4	Part of the evolutionarily-conserved CCR4-NOT transcriptional regulatory complex involved in controlling mRNA initiation, elongation, and degradation [Source:SGD;Acc:S000005222]
N	YNL279W	PRM1	21	-3.1	2	Pheromone-regulated multispanning membrane protein involved in membrane fusion during mating; predicted to have 5 transmembrane segments and a coiled coil domain; localizes to the shmoo tip; regulated by Ste12p [Source:SGD;Acc:S000005223]
N	YNL280C	ERG24	458	-95.6	4	C-14 sterol reductase, acts in ergosterol biosynthesis; mutants accumulate the abnormal sterol ignosterol (ergosta-8,14 dienol), and are viable under anaerobic growth conditions but inviable on rich medium under aerobic conditions [Source:SGD;Acc:S000005224]
N	YNL281W	HCH1	1345	-191.1	4	Heat shock protein regulator that binds to Hsp90p and may stimulate ATPase activity; originally identified as a high-copy number suppressor of a HSP90 loss-of-function mutation; GFP-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000005225]
N	YNL282W	POP3	89	-30.1	4	Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs [Source:SGD;Acc:S000005226]
N	YNL283C	WSC2	147	-46.9	4	Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity and recovery from heat shock; secretory pathway Wsc2p is required for the arrest of secretion response [Source:SGD;Acc:S000005227]
N	YNL284C	MRPL10	547	-228.8	4	Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL10 and YmL18) on two-dimensional SDS gels [Source:SGD;Acc:S000005228]
N	YNL284C-A	YNL284C-A	3324	-941.4	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007386]
N	YNL284C-B	YNL284C-B	3980	-1523.4	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007387]
N	YNL285W	YNL285W	1	-1	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005229]
N	YNL286W	CUS2	169	-67.5	4	Protein that binds to U2 snRNA and Prp11p, may be involved in U2 snRNA folding; contains two RNA recognition motifs (RRMs) [Source:SGD;Acc:S000005230]
N	YNL287W	SEC21	2893	-1299.8	4	Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo [Source:SGD;Acc:S000005231]
N	YNL288W	CAF40	442	-223.2	4	Evolutionarily conserved subunit of the CCR4-NOT complex involved in controlling mRNA initiation, elongation and degradation; binds Cdc39p [Source:SGD;Acc:S000005232]
N	YNL289W	PCL1	82	-150.6	4	Cyclin, interacts with cyclin-dependent kinase Pho85p; member of the Pcl1,2-like subfamily, involved in the regulation of polarized growth and morphogenesis and progression through the cell cycle; localizes to sites of polarized cell growth [Source:SGD;Acc:S000005233]
N	YNL290W	RFC3	1212	-325.6	4	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon [Source:SGD;Acc:S000005234]
N	YNL291C	MID1	74	-37.8	4	N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer [Source:SGD;Acc:S000005235]
N	YNL292W	PUS4	827	-337.1	4	Pseudouridine synthase, catalyzes only the formation of pseudouridine-55 (Psi55), a highly conserved tRNA modification, in mitochondrial and cytoplasmic tRNAs; PUS4 overexpression leads to translational derepression of GCN4 (Gcd- phenotype) [Source:SGD;Acc:S000005236]
N	YNL293W	MSB3	302	-180.5	4	GTPase-activating protein for Sec4p and several other Rab GTPases, regulates exocytosis via its action on Sec4p, also required for proper actin organization; similar to Msb4p; both Msb3p and Msb4p localize to sites of polarized growth [Source:SGD;Acc:S000005237]
N	YNL294C	RIM21	22	-13.5	4	Component of the RIM101 pathway, has a role in cell wall construction and alkaline pH response; has similarity to A. nidulans PalH [Source:SGD;Acc:S000005238]
N	YNL295W	YNL295W	52	-109.9	4	Putative protein of unknown function [Source:SGD;Acc:S000005239]
N	YNL296W	YNL296W	2	-1.5	1	Dubious open reading frame unlikely to encode a functional protein; deletion adversely affects sporulation; deletion mutant exhibits synthetic phenotype under expression of mutant huntingtin fragment, but gene does not have human ortholog [Source:SGD;Acc:S000005240]
N	YNL297C	MON2	840	-618.6	4	Peripheral membrane protein with a role in endocytosis and vacuole integrity, interacts with Arl1p and localizes to the endosome; member of the Sec7p family of proteins [Source:SGD;Acc:S000005241]
N	YNL298W	CLA4	871	-2210	4	Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p [Source:SGD;Acc:S000005242]
N	YNL299W	TRF5	129	-63.7	4	Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Pap2p [Source:SGD;Acc:S000005243]
N	YNL300W	TOS6	3	-2.3	2	Glycosylphosphatidylinositol-dependent cell wall protein, expression is periodic and decreases in respone to ergosterol perturbation or upon entry into stationary phase; depletion increases resistance to lactic acid [Source:SGD;Acc:S000005244]
N	YNL301C	RPL18B	3973	-363.5	4	Protein component of the large (60S) ribosomal subunit, identical to Rpl18Ap and has similarity to rat L18 ribosomal protein [Source:SGD;Acc:S000005245]
N	YNL302C	RPS19B	4282	-446.1	4	Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Ap [Source:SGD;Acc:S000005246]
N	YNL303W	YNL303W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005247]
N	YNL304W	YPT11	141	-126	4	Rab family GTPase that interacts with the C-terminal tail domain of Myo2p; mediates distribution of mitochondria and endoplasmic reticuli to daughter cells [Source:SGD;Acc:S000005248]
N	YNL305C	BXI1	130	-68.5	4	Protein involved in apoptosis; variously described as containing a BCL-2 homology (BH3) domain or as a member of the BAX inhibitor family; reported to promote apoptosis under some conditions and to inhibit it in others; localizes to ER and vacuole;   nk the unfolded protein response to apoptosis via regulation of calcium-mediated signaling; translocates to mitochondria under apoptosis-inducing conditions in a process involving Mir1p and Cor1p [Source:SGD;Acc:S000005249]
N	YNL306W	MRPS18	384	-117.5	4	Mitochondrial ribosomal protein of the small subunit; essential for viability, unlike most other mitoribosomal proteins [Source:SGD;Acc:S000005250]
N	YNL307C	MCK1	2053	-895.1	4	Protein serine/threonine/tyrosine (dual-specificity) kinase involved in control of chromosome segregation and in regulating entry into meiosis; related to mammalian glycogen synthase kinases of the GSK-3 family [Source:SGD;Acc:S000005251]
N	YNL308C	KRI1	1846	-386.4	4	Essential nucleolar protein required for 40S ribosome biogenesis; physically and functionally interacts with Krr1p [Source:SGD;Acc:S000005252]
N	YNL309W	STB1	433	-114	4	Protein with a role in regulation of MBF-specific transcription at Start, phosphorylated by Cln-Cdc28p kinases in vitro; unphosphorylated form binds Swi6p and binding is required for Stb1p function; expression is cell-cycle regulated [Source:SGD;Acc:S000005253]
N	YNL310C	ZIM17	379	-95.2	4	Heat shock protein with a zinc finger motif; essential for protein import into mitochondria; may act with Pam18p to facilitate recognition and folding of imported proteins by Ssc1p (mtHSP70) in the mitochondrial matrix [Source:SGD;Acc:S000005254]
N	YNL311C	SKP2	166	-138.8	4	F-box protein of unknown function predicted to be part of an SCF ubiquitin protease complex; involved in regulating protein levels of sulfur metabolism enzymes; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000005255]
N	YNL312W	RFA2	1328	-233.1	4	Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination [Source:SGD;Acc:S000005256]
N	YNL313C	EMW1	1246	-593.9	4	Essential conserved protein with a role in maintaining cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1 [Source:SGD;Acc:S000005257]
N	YNL314W	DAL82	63	-57.4	4	Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain [Source:SGD;Acc:S000005258]
N	YNL315C	ATP11	933	-190.6	4	Molecular chaperone, required for the assembly of alpha and beta subunits into the F1 sector of mitochondrial F1F0 ATP synthase [Source:SGD;Acc:S000005259]
N	YNL316C	PHA2	374	-159.6	4	Prephenate dehydratase, catalyzes the conversion of prephanate to phenylpyruvate, which is a step in the phenylalanine biosynthesis pathway [Source:SGD;Acc:S000005260]
N	YNL317W	PFS2	241	-161.3	4	Integral subunit of the pre-mRNA cleavage and polyadenylation factor (CPF) complex; plays an essential role in mRNA 3'-end formation by bridging different processing factors and thereby promoting the assembly of the processing complex [Source:SGD;Acc:S000005261]
N	YNL318C	HXT14	14	-2	2	Protein with similarity to hexose transporter family members, expression is induced in low glucose and repressed in high glucose; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005262]
N	YNL319W	YNL319W	2	-1.4	1	Dubious open reading frame unlikely to encode a protein; partially overlaps the verified gene HXT14 [Source:SGD;Acc:S000005263]
N	YNL320W	YNL320W	159	-73.9	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005264]
N	YNL321W	VNX1	605	-171.7	4	Calcium/H+ antiporter localized to the endoplasmic reticulum membrane; member of the calcium exchanger (CAX) family; potential Cdc28p substrate [Source:SGD;Acc:S000005265]
N	YNL322C	KRE1	1	-2.2	2	Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor [Source:SGD;Acc:S000005266]
N	YNL323W	LEM3	950	-249	4	Membrane protein of the plasma membrane and ER, interacts specifically in vivo with the phospholipid translocase (flippase) Dnf1p; involved in translocation of phospholipids and alkylphosphocholine drugs across the plasma membrane [Source:SGD;Acc:S000005267]
N	YNL324W	YNL324W	2	-1.7	1	Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005268]
N	YNL325C	FIG4	199	-81.9	4	Phosphatidylinositol 3,5-bisphosphate (PtdIns[3,5]P) phosphatase; required for efficient mating and response to osmotic shock; physically associates with and regulated by Vac14p; contains a SAC1-like domain [Source:SGD;Acc:S000005269]
N	YNL326C	PFA3	54	-79	4	Palmitoyltransferase for Vac8p, required for vacuolar membrane fusion; contains an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; autoacylates; required for vacuolar integrity under stress conditions [Source:SGD;Acc:S000005270]
N	YNL327W	EGT2	151	-226	4	Glycosylphosphatidylinositol (GPI)-anchored cell wall endoglucanase required for proper cell separation after cytokinesis, expression is activated by Swi5p and tightly regulated in a cell cycle-dependent manner [Source:SGD;Acc:S000005271]
N	YNL328C	MDJ2	56	-39.7	4	Constituent of the mitochondrial import motor associated with the presequence translocase; function overlaps with that of Pam18p; stimulates the ATPase activity of Ssc1p to drive mitochondrial import; contains a J domain [Source:SGD;Acc:S000005272]
N	YNL329C	PEX6	230	-312.7	4	AAA-peroxin that heterodimerizes with AAA-peroxin Pex1p and participates in the recycling of peroxisomal signal receptor Pex5p from the peroxisomal membrane to the cystosol [Source:SGD;Acc:S000005273]
N	YNL330C	RPD3	922	-354.3	4	Histone deacetylase; regulates transcription, silencing, and other processes by influencing chromatin remodeling; forms at least two different complexes which have distinct functions and members [Source:SGD;Acc:S000005274]
N	YNL331C	AAD14	21	-8.6	2	Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role [Source:SGD;Acc:S000005275]
N	YNL332W	THI12	51	-139.4	4	Protein involved in synthesis of the thiamine precursor hydroxymethylpyrimidine (HMP); member of a subtelomeric gene family including THI5, THI11, THI12, and THI13 [Source:SGD;Acc:S000005276]
N	YNL333W	SNZ2	489	-142.3	4	Member of a stationary phase-induced gene family; transcription of SNZ2 is induced prior to diauxic shift, and also in the absence of thiamin in a Thi2p-dependent manner; forms a coregulated gene pair with SNO2; interacts with Thi11p [Source:SGD;Acc:S000005277]
N	YNL334C	SNO2	79	-60.5	4	Protein of unknown function, nearly identical to Sno3p; expression is induced before the diauxic shift and also in the absence of thiamin [Source:SGD;Acc:S000005278]
N	YNL335W	DDI3	17	-27.9	4	Protein of unknown function; expression is induced over 100-fold by DNA damage; induction decreased in rad6 and rad18 mutants [Source:SGD;Acc:S000005279]
N	YNL336W	COS1	224	-76.9	4	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000005280]
N	YNL337W	YNL337W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005281]
N	YNL338W	YNL338W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps TEL14L-XC, which is Telomeric X element Core sequence on the left arm of Chromosome XIV [Source:SGD;Acc:S000005282]
N	YNL339C	YRF1-6	450	-491.1	4	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000005283]
N	YNL339W-A	YNL339W-A	14	-25.7	2	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028703]
N	YNL339W-B	YNL339W-B	43	-1.6	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028704]
N	YNR001C	CIT1	2774	-1489.2	4	Citrate synthase, catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate; the rate-limiting enzyme of the TCA cycle; nuclear encoded mitochondrial protein [Source:SGD;Acc:S000005284]
N	YNR001W-A	YNR001W-A	9	-4	2	Dubious open reading frame unlikely to encode a functional protein; identified by homology [Source:SGD;Acc:S000007625]
N	YNR002C	ATO2	156	-144.3	4	Putative transmembrane protein involved in export of ammonia, a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Ady2p and Y. lipolytica Gpr1p [Source:SGD;Acc:S000005285]
N	YNR003C	RPC34	434	-214.7	4	RNA polymerase III subunit C34; interacts with TFIIIB70 and is a key determinant in pol III recruitment by the preinitiation complex [Source:SGD;Acc:S000005286]
N	YNR003W-A	YNR003W-A	6	-3.5	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene RPC34/YNR003C [Source:SGD;Acc:S000028705]
N	YNR004W	SWM2	23	-40.1	4	Putative protein of unknown function; haploid disruptant exhibits cold-sensitive growth and elongated buds [Source:SGD;Acc:S000005287]
N	YNR005C	YNR005C	1	-1.6	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005288]
N	YNR006W	VPS27	944	-437.4	4	Endosomal protein that forms a complex with Hse1p; required for recycling Golgi proteins, forming lumenal membranes and sorting ubiquitinated proteins destined for degradation; has Ubiquitin Interaction Motifs which bind ubiquitin (Ubi4p) [Source:SGD;Acc:S000005289]
N	YNR007C	ATG3	306	-180.9	4	E2-like enzyme involved in autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; plays a role in formation of Atg8p-phosphatidylethanolamine conjugates, which are involved in membrane dynamics during autophagy and Cvt [Source:SGD;Acc:S000005290]
N	YNR008W	LRO1	461	-312.4	4	Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase [Source:SGD;Acc:S000005291]
N	YNR009W	NRM1	105	-47.6	4	Transcriptional co-repressor of MBF (MCB binding factor)-regulated gene expression; Nrm1p associates stably with promoters via MBF to repress transcription upon exit from G1 phase [Source:SGD;Acc:S000005292]
N	YNR010W	CSE2	169	-119.3	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; component of the Middle domain of mediator; required for regulation of RNA polymerase II activity [Source:SGD;Acc:S000005293]
N	YNR011C	PRP2	508	-216.9	4	RNA-dependent ATPase in the DEAH-box family, required for activation of the spliceosome before the first transesterification step in RNA splicing; orthologous to human protein DHX16 [Source:SGD;Acc:S000005294]
N	YNR012W	URK1	393	-1158.5	4	Uridine/cytidine kinase, component of the pyrimidine ribonucleotide salvage pathway that converts uridine into UMP and cytidine into CMP; involved in the pyrimidine deoxyribonucleotide salvage pathway, converting deoxycytidine into dCMP [Source:SGD;Acc:S000005295]
N	YNR013C	PHO91	879	-310.2	4	Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth [Source:SGD;Acc:S000005296]
N	YNR014W	YNR014W	201	-39.6	4	Putative protein of unknown function; expression is cell-cycle regulated, Azf1p-dependent, and heat-inducible [Source:SGD;Acc:S000005297]
N	YNR015W	SMM1	444	-245.5	4	Dihydrouridine synthase, member of a family of dihydrouridine synthases including Dus1p, Smm1p, Dus3p, and Dus4p; modifies uridine residues at position 20 of cytoplasmic tRNAs [Source:SGD;Acc:S000005298]
N	YNR016C	ACC1	4526	-4552.2	4	Acetyl-CoA carboxylase, biotin containing enzyme that catalyzes the carboxylation of acetyl-CoA to form malonyl-CoA; required for de novo biosynthesis of long-chain fatty acids [Source:SGD;Acc:S000005299]
N	YNR017W	TIM23	1100	-271	4	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein import into mitochondrial matrix and inner membrane; with Tim17p, contributes to architecture and function of the import channel [Source:SGD;Acc:S000005300]
N	YNR018W	RCF2	524	-132.5	4	Putative protein of unknown function; non-tagged protein is detected in purified mitochondria; may interact with respiratory chain complex IV; null mutant is viable and displays reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000005301]
N	YNR019W	ARE2	796	-293.6	4	Acyl-CoA:sterol acyltransferase, isozyme of Are1p; endoplasmic reticulum enzyme that contributes the major sterol esterification activity in the presence of oxygen [Source:SGD;Acc:S000005302]
N	YNR020C	ATP23	103	-77.7	4	Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex [Source:SGD;Acc:S000005303]
N	YNR021W	YNR021W	1849	-461.3	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YNR021W is not an essential gene [Source:SGD;Acc:S000005304]
N	YNR022C	MRPL50	279	-96.2	4	Mitochondrial ribosomal protein of the large subunit, not essential for mitochondrial translation [Source:SGD;Acc:S000005305]
N	YNR023W	SNF12	448	-212.9	4	73 kDa subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; homolog of Rsc6p subunit of the RSC chromatin remodeling complex; deletion mutants are temperature-sensitive [Source:SGD;Acc:S000005306]
N	YNR024W	MPP6	326	-116.9	4	Nuclear exosome-associated RNA binding protein; involved in surveillance of pre-rRNAs and pre-mRNAs, and the degradation of cryptic non-coding RNAs (ncRNA); copurifies with ribosomes [Source:SGD;Acc:S000005307]
N	YNR025C	YNR025C	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; deletion reduces expression of PIS1 gene encoding phosphatidylinositol synthase [Source:SGD;Acc:S000005308]
N	YNR026C	SEC12	648	-165.1	4	Guanine nucleotide exchange factor (GEF), activates Sar1p by catalyzing the exchange of GDP for GTP; required for the initiation of COPII vesicle formation in ER to Golgi transport; glycosylated integral membrane protein of the ER [Source:SGD;Acc:S000005309]
N	YNR027W	BUD17	237	-138.2	4	Putative pyridoxal kinase, a key enzyme in vitamin B6 metabolism; involved in bud-site selection; diploid mutants display a random rather than a bipolar budding pattern; similarity to yeast BUD16 and human pyridoxal kinase (PDXK) [Source:SGD;Acc:S000005310]
N	YNR028W	CPR8	141	-163.5	4	Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway [Source:SGD;Acc:S000005311]
N	YNR029C	YNR029C	514	-199.7	4	Putative protein of unknown function, deletion confers reduced fitness in saline [Source:SGD;Acc:S000005312]
N	YNR030W	ALG12	486	-184.4	4	Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation [Source:SGD;Acc:S000005313]
N	YNR031C	SSK2	419	-1528.3	4	MAP kinase kinase kinase of the HOG1 mitogen-activated signaling pathway; interacts with Ssk1p, leading to autophosphorylation and activation of Ssk2p which phosphorylates Pbs2p; also mediates actin cytoskeleton recovery from osmotic stress [Source:SGD;Acc:S000005314]
N	YNR032C-A	HUB1	391	-58.4	4	Ubiquitin-like protein modifier; promotes alternative splicing of SRC1 pre-mRNA; binds non-covalently to the HIND domain of Snu66, may function in modification of Sph1p and Hbt1p, functionally complemented by the human or S. pombe ortholog; mechanis  ub1p adduct formation not yet clear [Source:SGD;Acc:S000007251]
N	YNR032W	PPG1	114	-329.1	4	Putative serine/threonine protein phosphatase of the type 2A-like phosphatase family, required for glycogen accumulation; interacts with Tap42p, which binds to and regulates other protein phosphatases [Source:SGD;Acc:S000005315]
N	YNR033W	ABZ1	459	-217.6	4	Para-aminobenzoate (PABA) synthase, has similarity to Escherichia coli PABA synthase components PabA and PabB; required for the synthesis of para-aminobenzoic acid, an important intermediate for folate and ubiquinone Q biosynthesis [Source:SGD;Acc:S000005316]
N	YNR034W	SOL1	926	-208	4	Protein with a possible role in tRNA export; shows similarity to 6-phosphogluconolactonase non-catalytic domains but does not exhibit this enzymatic activity; homologous to Sol2p, Sol3p, and Sol4p [Source:SGD;Acc:S000005317]
N	YNR034W-A	YNR034W-A	1057	-333.7	4	Putative protein of unknown function; expression is regulated by Msn2p/Msn4p [Source:SGD;Acc:S000007525]
N	YNR035C	ARC35	1681	-442.1	4	Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; required for cortical localization of calmodulin [Source:SGD;Acc:S000005318]
N	YNR036C	MRPS12	350	-105.1	4	Mitochondrial protein; may interact with ribosomes based on co-purification experiments; similar to E. coli and human mitochondrial S12 ribosomal proteins [Source:SGD;Acc:S000005319]
N	YNR037C	RSM19	296	-75.7	4	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S19 ribosomal protein [Source:SGD;Acc:S000005320]
N	YNR038W	DBP6	996	-322.9	4	Essential protein involved in ribosome biogenesis; putative ATP-dependent RNA helicase of the DEAD-box protein family [Source:SGD;Acc:S000005321]
N	YNR039C	ZRG17	262	-163.2	4	Endoplasmic reticulum protein of unknown function, transcription is induced under conditions of zinc deficiency; mutant phenotype suggests a role in uptake of zinc [Source:SGD;Acc:S000005322]
N	YNR040W	YNR040W	337	-114.6	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005323]
N	YNR041C	COQ2	77	-84.5	4	Para hydroxybenzoate: polyprenyl transferase, catalyzes the second step in ubiquinone (coenzyme Q) biosynthesis [Source:SGD;Acc:S000005324]
N	YNR042W	YNR042W	4	-3.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2 [Source:SGD;Acc:S000005325]
N	YNR043W	MVD1	2131	-948.3	4	Mevalonate pyrophosphate decarboxylase, essential enzyme involved in the biosynthesis of isoprenoids and sterols, including ergosterol; acts as a homodimer [Source:SGD;Acc:S000005326]
N	YNR044W	AGA1	2	-1.4	1	Anchorage subunit of a-agglutinin of a-cells, highly O-glycosylated protein with N-terminal secretion signal and C-terminal signal for addition of GPI anchor to cell wall, linked to adhesion subunit Aga2p via two disulfide bonds [Source:SGD;Acc:S000005327]
N	YNR045W	PET494	146	-131.9	4	Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane [Source:SGD;Acc:S000005328]
N	YNR046W	TRM112	964	-100.7	4	Subunit of tRNA methyltransferase (MTase) complexes in combination with Trm9p and Trm11p; subunit of complex with Mtq2p that methylates Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; deletion confers resistance to zymocin [Source:SGD;Acc:S000005329]
N	YNR047W	FPK1	838	-1214.5	4	Ser/Thr protein kinase that regulates the putative phospholipid translocases Lem3p-Dnf1p/Dnf2p; phosphorylates and inhibits upstream inhibitory kinase, Ypk1p; localizes to the cytoplasm, early endosome/TGN compartments, and plasma membrane [Source:SGD;Acc:S000005330]
N	YNR048W	YNR048W	87	-102.9	4	Protein that interacts specifically in vivo with phospholipid translocase (flippase) Dnf3p; similar to Cdc50p, which is an essential interaction partner of the flippase Drs2p [Source:SGD;Acc:S000005331]
N	YNR049C	MSO1	427	-108.5	4	Probable component of the secretory vesicle docking complex, acts at a late step in secretion; shows genetic and physical interactions with Sec1p; required for prospore membrane formation during sporulation [Source:SGD;Acc:S000005332]
N	YNR050C	LYS9	1914	-555.9	4	Saccharopine dehydrogenase (NADP+, L-glutamate-forming); catalyzes the formation of saccharopine from alpha-aminoadipate 6-semialdehyde, the seventh step in lysine biosynthesis pathway; exhibits genetic and physical interactions with TRM112 [Source:SGD;Acc:S000005333]
N	YNR051C	BRE5	1405	-543.3	4	Ubiquitin protease cofactor, forms deubiquitination complex with Ubp3p that coregulates anterograde and retrograde transport between the endoplasmic reticulum and Golgi compartments; null is sensitive to brefeldin A [Source:SGD;Acc:S000005334]
N	YNR052C	POP2	818	-260.4	4	RNase of the DEDD superfamily, subunit of the Ccr4-Not complex that mediates 3' to 5' mRNA deadenylation [Source:SGD;Acc:S000005335]
N	YNR053C	NOG2	1566	-408.4	4	Putative GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation [Source:SGD;Acc:S000005336]
N	YNR054C	ESF2	628	-168.8	4	Essential nucleolar protein involved in pre-18S rRNA processing; binds to RNA and stimulates ATPase activity of Dbp8; involved in assembly of the small subunit (SSU) processome [Source:SGD;Acc:S000005337]
N	YNR055C	HOL1	51	-77.1	4	Putative transporter in the major facilitator superfamily (DHA1 family) of multidrug resistance transporters; mutations in membrane-spanning domains permit cation and histidinol uptake [Source:SGD;Acc:S000005338]
N	YNR056C	BIO5	10	-92.6	2	Putative transmembrane protein involved in the biotin biosynthesis pathway; responsible for uptake of 7-keto 8-aminopelargonic acid; BIO5 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis [Source:SGD;Acc:S000005339]
N	YNR057C	BIO4	210	-198.8	4	Dethiobiotin synthetase, catalyzes the third step in the biotin biosynthesis pathway; BIO4 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis; expression appears to be repressed at low iron levels [Source:SGD;Acc:S000005340]
N	YNR058W	BIO3	134	-576	4	7,8-diamino-pelargonic acid aminotransferase (DAPA), catalyzes the second step in the biotin biosynthesis pathway; BIO3 is in a cluster of 3 genes (BIO3, BIO4, and BIO5) that mediate biotin synthesis [Source:SGD;Acc:S000005341]
N	YNR059W	MNT4	19	-57.1	2	Putative alpha-1,3-mannosyltransferase, not required for protein O-glycosylation [Source:SGD;Acc:S000005342]
N	YNR060W	FRE4	31	-48	4	Ferric reductase, reduces a specific subset of siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels [Source:SGD;Acc:S000005343]
N	YNR061C	YNR061C	65	-22.7	4	Putative protein of unknown function [Source:SGD;Acc:S000005344]
N	YNR062C	YNR062C	12	-14.4	2	Putative membrane protein of unknown function [Source:SGD;Acc:S000005345]
N	YNR063W	YNR063W	58	-18.3	4	Putative zinc-cluster protein of unknown function [Source:SGD;Acc:S000005346]
N	YNR064C	YNR064C	32	-63.7	4	Epoxide hydrolase, member of the alpha/beta hydrolase fold family; may have a role in detoxification of epoxides [Source:SGD;Acc:S000005347]
N	YNR065C	YNR065C	496	-286.4	4	Protein of unknown function; protein-protein interactions suggest a possible role in actin patch formation; YNR065C is not an essential gene [Source:SGD;Acc:S000005348]
N	YNR066C	YNR066C	64	-196.3	4	Putative membrane-localized protein of unknown function [Source:SGD;Acc:S000005349]
N	YNR067C	DSE4	694	-534.4	4	Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother [Source:SGD;Acc:S000005350]
N	YNR068C	YNR068C	11	-8.5	2	Putative protein of unknown function [Source:SGD;Acc:S000005351]
N	YNR069C	BSC5	41	-19.6	4	Protein of unknown function, ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression [Source:SGD;Acc:S000005352]
N	YNR070W	PDR18	565	-79.1	4	Putative transporter of the ATP-binding cassette (ABC) family, implicated in pleiotropic drug resistance; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005353]
N	YNR071C	YNR071C	26	-54.4	3	Putative protein of unknown function [Source:SGD;Acc:S000005354]
N	YNR072W	HXT17	234	-22.2	2	Hexose transporter, up-regulated in media containing raffinose and galactose at pH 7.7 versus pH 4.7, repressed by high levels of glucose [Source:SGD;Acc:S000005355]
N	YNR073C	YNR073C	116	-356.6	4	Putative mannitol dehydrogenase [Source:SGD;Acc:S000005356]
N	YNR074C	AIF1	187	-221.3	4	Mitochondrial cell death effector that translocates to the nucleus in response to apoptotic stimuli, homolog of mammalian Apoptosis-Inducing Factor, putative reductase [Source:SGD;Acc:S000005357]
N	YNR075C-A	YNR075C-A	11	-10.5	2	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028706]
N	YNR075W	COS10	10	-20.4	2	Protein of unknown function, member of the DUP380 subfamily of conserved, often subtelomerically-encoded proteins [Source:SGD;Acc:S000005358]
N	YNR076W	PAU6	0	nf	1	Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme; identical to Pau18p [Source:SGD;Acc:S000005359]
N	YNR077C	YNR077C	1	-1.6	1	Protein of unknown function, abundance changes with carbon source [Source:SGD;Acc:S000005360]
O	YOL001W	PHO80	38	-523.3	4	Cyclin, interacts with cyclin-dependent kinase Pho85p; regulates the response to nutrient levels and environmental conditions, including the response to phosphate limitation and stress-dependent calcium signaling [Source:SGD;Acc:S000005361]
O	YOL002C	IZH2	96	-38.4	4	Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc [Source:SGD;Acc:S000005362]
O	YOL003C	PFA4	40	-67.1	4	Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases [Source:SGD;Acc:S000005363]
O	YOL004W	SIN3	1483	-927.6	4	Component of the Sin3p-Rpd3p histone deacetylase complex, involved in transcriptional repression and activation of diverse processes, including mating-type switching and meiosis; involved in the maintenance of chromosomal integrity [Source:SGD;Acc:S000005364]
O	YOL005C	RPB11	694	-116	4	RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit [Source:SGD;Acc:S000005365]
O	YOL006C	TOP1	1183	-391.1	4	Topoisomerase I, nuclear enzyme that relieves torsional strain in DNA by cleaving and re-sealing the phosphodiester backbone; relaxes both positively and negatively supercoiled DNA; functions in replication, transcription, and recombination [Source:SGD;Acc:S000005366]
O	YOL007C	CSI2	75	-30.7	4	Protein of unknown function; green fluorescent protein (GFP)- fusion protein localizes to the mother side of the bud neck and the vacuole; YOL007C is not an essential gene [Source:SGD;Acc:S000005367]
O	YOL008W	COQ10	144	-89.7	4	Coenzyme Q (ubiquinone) binding protein, functions in the delivery of Q<sub>6</sub> to its proper location for electron transport during respiration; START domain protein with homologs in bacteria and eukaryotes [Source:SGD;Acc:S000005368]
O	YOL009C	MDM12	135	-84	4	Mitochondrial outer membrane protein, required for transmission of mitochondria to daughter cells; component of the ERMES complex that links the ER to mitochondria; may influence import and assembly of outer membrane beta-barrel proteins [Source:SGD;Acc:S000005369]
O	YOL010W	RCL1	934	-308	4	Endonuclease that cleaves pre-rRNA at site A2 for 18S rRNA biogenesis; subunit of U3-containing 90S preribosome processome complex involved in small ribosomal subunit assembly; stimulates Bms1p GTPase and U3 binding activity; similar to RNA cyclase-  roteins but no cyclase activity detected [Source:SGD;Acc:S000005370]
O	YOL011W	PLB3	134	-115.9	4	Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro [Source:SGD;Acc:S000005371]
O	YOL012C	HTZ1	1945	-176.9	4	Histone variant H2AZ, exchanged for histone H2A in nucleosomes by the SWR1 complex; involved in transcriptional regulation through prevention of the spread of silent heterochromatin [Source:SGD;Acc:S000005372]
O	YOL013C	HRD1	132	-90.7	4	Ubiquitin-protein ligase required for endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins; genetically linked to the unfolded protein response (UPR); regulated through association with Hrd3p; contains an H2 ring finger [Source:SGD;Acc:S000005373]
O	YOL013W-A	YOL013W-A	3	-1.8	1	Putative protein of unknown function; identified by SAGE [Source:SGD;Acc:S000028811]
O	YOL013W-B	YOL013W-B	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the long terminal repeat (LTR) of a Ty1 element [Source:SGD;Acc:S000007252]
O	YOL014W	YOL014W	4	-2.6	2	Putative protein of unknown function [Source:SGD;Acc:S000005374]
O	YOL015W	IRC10	17	-4	2	Putative protein of unknown function; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000005375]
O	YOL016C	CMK2	904	-617.2	4	Calmodulin-dependent protein kinase; may play a role in stress response, many CA++/calmodulan dependent phosphorylation substrates demonstrated in vitro, amino acid sequence similar to Cmk1p and mammalian Cam Kinase II [Source:SGD;Acc:S000005376]
O	YOL017W	ESC8	66	-43.7	4	Protein involved in telomeric and mating-type locus silencing, interacts with Sir2p and also interacts with the Gal11p, which is a component of the RNA pol II mediator complex [Source:SGD;Acc:S000005377]
O	YOL018C	TLG2	369	-287.1	4	Syntaxin-like t-SNARE that forms a complex with Tlg1p and Vti1p and mediates fusion of endosome-derived vesicles with the late Golgi; binds Vps45p, which prevents Tlg2p degradation and also facilitates t-SNARE complex formation; homologous to mammal  ARE protein syntaxin 16 (Sx16) [Source:SGD;Acc:S000005378]
O	YOL019W	YOL019W	466	-253.1	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole [Source:SGD;Acc:S000005379]
O	YOL019W-A	YOL019W-A	2	-1.3	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028707]
O	YOL020W	TAT2	89	-29.2	4	High affinity tryptophan and tyrosine permease, overexpression confers FK506 and FTY720 resistance [Source:SGD;Acc:S000005380]
O	YOL021C	DIS3	1475	-2044	4	Exosome core complex catalytic subunit; possesses both endonuclease and 3'-5' exonuclease activity; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; has similarity to E. coli RNase R and to human DIS3 [Source:SGD;Acc:S000005381]
O	YOL022C	TSR4	921	-319.8	4	Cytoplasmic protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; essential gene in S288C background but not in CEN.PK2 [Source:SGD;Acc:S000005382]
O	YOL023W	IFM1	249	-340.5	4	Mitochondrial translation initiation factor 2 [Source:SGD;Acc:S000005383]
O	YOL024W	YOL024W	2	-1.8	1	Putative protein of unknown function; predicted to have thiol-disulfide oxidoreductase active site [Source:SGD;Acc:S000005384]
O	YOL025W	LAG2	244	-248.2	4	Protein that negatively regulates the SCF E3-ubiquitin ligase by interacting with and preventing neddyation of the cullin subunit, Cdc53p; longevity determinant that is preferentially expressed in young cells; similar to mammalian Cand1 [Source:SGD;Acc:S000005385]
O	YOL026C	MIM1	23	-17.8	3	Mitochondrial protein required for outer membrane protein import; cooperates with Tom70p to import the subset of proteins with multiple alpha-helical transmembrane segments, including Ugo1p, Tom20p, and others; present as an oligomer in the outer me   that may create a local environment that facilitates membrane insertion of substrate proteins; also has a role in assembly of Tom20p into the TOM complex [Source:SGD;Acc:S000005386]
O	YOL027C	MDM38	1332	-683.9	4	Mitochondrial protein, forms a complex with Mba1p to facilitate recruitment of mRNA-specific translational activators to ribosomes; roles in protein export and K+/H+ exchange; human ortholog Letm1 implicated in Wolf-Hirschhorn syndrome [Source:SGD;Acc:S000005387]
O	YOL028C	YAP7	31	-12.8	4	Putative basic leucine zipper (bZIP) transcription factor [Source:SGD;Acc:S000005388]
O	YOL029C	YOL029C	15	-2.6	2	Putative protein of unknown function; identified as interacting with Hsc82p and Hsp82p in high-throughput two-hybrid screens [Source:SGD;Acc:S000005389]
O	YOL030W	GAS5	1418	-354.3	4	1,3-beta-glucanosyltransferase, has similarity to Gas1p; localizes to the cell wall [Source:SGD;Acc:S000005390]
O	YOL031C	SIL1	616	-207.6	4	Nucleotide exchange factor for the endoplasmic reticulum (ER) lumenal Hsp70 chaperone Kar2p, required for protein translocation into the ER; homolog of Yarrowia lipolytica SLS1; GrpE-like protein [Source:SGD;Acc:S000005391]
O	YOL032W	OPI10	371	-129.6	4	Protein with a possible role in phospholipid biosynthesis, based on inositol-excreting phenotype of the null mutant and its suppression by exogenous choline [Source:SGD;Acc:S000005392]
O	YOL033W	MSE1	239	-187.7	4	Mitochondrial glutamyl-tRNA synthetase, predicted to be palmitoylated [Source:SGD;Acc:S000005393]
O	YOL034W	SMC5	155	-225.8	4	Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; binds single-stranded DNA and has ATPase activity; S. pombe homolog f   heterodimer with S. pombe Rad18p that is involved in DNA repair [Source:SGD;Acc:S000005394]
O	YOL035C	YOL035C	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005395]
O	YOL036W	YOL036W	206	-127.6	4	Protein of unknown function; potential Cdc28p substrate [Source:SGD;Acc:S000005396]
O	YOL037C	YOL037C	3	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOL036W [Source:SGD;Acc:S000005397]
O	YOL038C-A	YOL038C-A	2	-1.4	1	Putative protein of unknown function; identified by SAGE analysis [Source:SGD;Acc:S000028812]
O	YOL038W	PRE6	2048	-263.5	4	Alpha 4 subunit of the 20S proteasome; may replace alpha 3 subunit (Pre9p) under stress conditions to create a more active proteasomal isoform; GFP-fusion protein relocates from cytosol to the mitochondrial surface upon oxidative stress [Source:SGD;Acc:S000005398]
O	YOL039W	RPP2A	4054	-863.5	4	Ribosomal protein P2 alpha, a component of the ribosomal stalk, which is involved in the interaction between translational elongation factors and the ribosome; regulates the accumulation of P1 (Rpp1Ap and Rpp1Bp) in the cytoplasm [Source:SGD;Acc:S000005399]
O	YOL040C	RPS15	4026	-500.2	4	Protein component of the small (40S) ribosomal subunit; has similarity to E. coli S19 and rat S15 ribosomal proteins [Source:SGD;Acc:S000005400]
O	YOL041C	NOP12	2001	-385.4	4	Nucleolar protein involved in pre-25S rRNA processing and biogenesis of large 60S ribosomal subunit; contains an RNA recognition motif (RRM); binds to Ebp2; similar to Nop13p and Nsr1p [Source:SGD;Acc:S000005401]
O	YOL042W	NGL1	100	-96.4	4	Putative endonuclease, has a domain similar to a magnesium-dependent endonuclease motif in mRNA deadenylase Ccr4p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005402]
O	YOL043C	NTG2	37	-98.3	4	DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase involved in base excision repair, localizes to the nucleus; sumoylated [Source:SGD;Acc:S000005403]
O	YOL044W	PEX15	113	-75.4	4	Phosphorylated tail-anchored type II integral peroxisomal membrane protein required for peroxisome biogenesis, cells lacking Pex15p mislocalize peroxisomal matrix proteins to cytosol, overexpression results in impaired peroxisome assembly [Source:SGD;Acc:S000005404]
O	YOL045W	PSK2	548	-2962.6	4	One of two (see also PSK1) PAS domain containing S/T protein kinases; regulates sugar flux and translation in response to an unknown metabolite by phosphorylating Ugp1p and Gsy2p (sugar flux) and Caf20p, Tif11p and Sro9p (translation) [Source:SGD;Acc:S000005405]
O	YOL046C	YOL046C	8	-1.9	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data;almost completely overlaps the verified gene PSK2/YOL045W [Source:SGD;Acc:S000005406]
O	YOL047C	LDS2	8	-12.1	2	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000005407]
O	YOL048C	RRT8	24	-27.3	2	Putative protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles [Source:SGD;Acc:S000005408]
O	YOL049W	GSH2	1262	-444.4	4	Glutathione synthetase, catalyzes the ATP-dependent synthesis of glutathione (GSH) from gamma-glutamylcysteine and glycine; induced by oxidative stress and heat shock [Source:SGD;Acc:S000005409]
O	YOL050C	YOL050C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO) [Source:SGD;Acc:S000005410]
O	YOL051W	GAL11	1030	-274.1	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator [Source:SGD;Acc:S000005411]
O	YOL052C	SPE2	824	-266.4	4	S-adenosylmethionine decarboxylase, required for the biosynthesis of spermidine and spermine; cells lacking Spe2p require spermine or spermidine for growth in the presence of oxygen but not when grown anaerobically [Source:SGD;Acc:S000005412]
O	YOL052C-A	DDR2	2	-9.5	1	Multistress response protein, expression is activated by a variety of xenobiotic agents and environmental or physiological stresses [Source:SGD;Acc:S000005413]
O	YOL053W	AIM39	200	-250.4	4	Putative protein of unknown function; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000005414]
O	YOL054W	PSH1	497	-277.2	4	E3 ubiquitin ligase that mediates poyubiquitination and degradation of centromere-binding protein Cse4p and prevents Cse4p from mislocalizing to euchromatin; ubiquitylation of Cse4p may be antagonized by Scm3p [Source:SGD;Acc:S000005415]
O	YOL055C	THI20	630	-424.3	4	Trifunctional enzyme of thiamine biosynthesis, degradation and salvage; has hydroxymethylpyrimidine (HMP) kinase, HMP-phosphate (HMP-P) kinase and thiaminase activities; member of a gene family with THI21 and THI22; HMP and HMP-P kinase activity red   with Thi21p [Source:SGD;Acc:S000005416]
O	YOL056W	GPM3	337	-126.3	4	Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event [Source:SGD;Acc:S000005417]
O	YOL057W	YOL057W	1314	-596.6	4	Dipeptidyl-peptidase III; cleaves dipeptides from the amino terminus of target proteins; highly active on synthetic substrate Arg-Arg-2-naphthylamide; mammalian ortholog may be a biomarker for some cancers [Source:SGD;Acc:S000005418]
O	YOL058W	ARG1	2461	-856.6	4	Arginosuccinate synthetase, catalyzes the formation of L-argininosuccinate from citrulline and L-aspartate in the arginine biosynthesis pathway; potential Cdc28p substrate [Source:SGD;Acc:S000005419]
O	YOL059W	GPD2	2488	-353.5	4	NAD-dependent glycerol 3-phosphate dehydrogenase, homolog of Gpd1p, expression is controlled by an oxygen-independent signaling pathway required to regulate metabolism under anoxic conditions; located in cytosol and mitochondria [Source:SGD;Acc:S000005420]
O	YOL060C	MAM3	762	-180.8	4	Protein required for normal mitochondrial morphology, has similarity to hemolysins [Source:SGD;Acc:S000005421]
O	YOL061W	PRS5	1924	-647.3	4	5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes [Source:SGD;Acc:S000005422]
O	YOL062C	APM4	415	-196.9	4	Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport [Source:SGD;Acc:S000005423]
O	YOL063C	CRT10	114	-118	4	Protein involved in transcriptional regulation of RNR2 and RNR3; expression of the gene is induced by DNA damage and null mutations confer increased resistance to hydroxyurea; N-terminal region has a leucine repeat and a WD40 repeat [Source:SGD;Acc:S000005424]
O	YOL064C	MET22	1165	-274.1	4	Bisphosphate-3'-nucleotidase, involved in salt tolerance and methionine biogenesis; dephosphorylates 3'-phosphoadenosine-5'-phosphate and 3'-phosphoadenosine-5'-phosphosulfate, intermediates of the sulfate assimilation pathway [Source:SGD;Acc:S000005425]
O	YOL065C	INP54	311	-183.4	4	Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins [Source:SGD;Acc:S000005426]
O	YOL066C	RIB2	336	-233.6	4	Bifunctional enzyme with DRAP deaminase and tRNA:pseudouridine synthase activity; the deaminase catalyzes the third step in riboflavin biosynthesis and the synthase catalyzes formation of pseudouridine at position 32 in cytoplasmic tRNAs [Source:SGD;Acc:S000005427]
O	YOL067C	RTG1	413	-261.7	4	Transcription factor (bHLH) involved in interorganelle communication between mitochondria, peroxisomes, and nucleus [Source:SGD;Acc:S000005428]
O	YOL068C	HST1	179	-184.4	4	NAD(+)-dependent histone deacetylase; essential subunit of the Sum1p/Rfm1p/Hst1p complex required for ORC-dependent silencing and mitotic repression; non-essential subunit of the Set3C deacetylase complex; involved in telomere maintenance [Source:SGD;Acc:S000005429]
O	YOL069W	NUF2	219	-230.8	4	Component of the evolutionarily conserved kinetochore-associated Ndc80 complex (Ndc80p-Nuf2p-Spc24p-Spc25p); involved in chromosome segregation, spindle checkpoint activity and kinetochore clustering [Source:SGD;Acc:S000005430]
O	YOL070C	NBA1	836	-251.2	4	Protein of unknown function, localizes to the bud neck and cytoplasm; interacts with Nap1p; may interact with ribosomes, based on co-purification experiments; potential Cdc28p substrate [Source:SGD;Acc:S000005431]
O	YOL071W	SDH5	362	-118.2	4	Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma) [Source:SGD;Acc:S000005432]
O	YOL072W	THP1	198	-495.7	4	Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to  ascent mRNP; contains a PAM domain implicated in protein-protein binding [Source:SGD;Acc:S000005433]
O	YOL073C	DSC2	116	-73.3	4	Putative protein of unknown function [Source:SGD;Acc:S000005434]
O	YOL075C	YOL075C	103	-46.4	4	Putative ABC transporter [Source:SGD;Acc:S000005435]
O	YOL076W	MDM20	1014	-388.1	4	Non-catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes N-acetylation of proteins with specific N-terminal sequences; involved in mitochondrial inheritance and actin assembly [Source:SGD;Acc:S000005436]
O	YOL077C	BRX1	1671	-359.1	4	Nucleolar protein, constituent of 66S pre-ribosomal particles; depletion leads to defects in rRNA processing and a block in the assembly of large ribosomal subunits; possesses a sigma(70)-like RNA-binding motif [Source:SGD;Acc:S000005437]
O	YOL077W-A	ATP19	281	-64.6	4	Subunit k of the mitochondrial F1F0 ATP synthase, which is a large enzyme complex required for ATP synthesis; associated only with the dimeric form of ATP synthase [Source:SGD;Acc:S000007339]
O	YOL078W	AVO1	385	-336.1	4	Component of a membrane-bound complex containing the Tor2p kinase and other proteins, which may have a role in regulation of cell growth [Source:SGD;Acc:S000005438]
O	YOL079W	YOL079W	1	-2.3	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005439]
O	YOL080C	REX4	400	-146.5	4	Putative RNA exonuclease possibly involved in pre-rRNA processing and ribosome assembly [Source:SGD;Acc:S000005440]
O	YOL081W	IRA2	583	-715.1	4	GTPase-activating protein that negatively regulates RAS by converting it from the GTP- to the GDP-bound inactive form, required for reducing cAMP levels under nutrient limiting conditions, has similarity to Ira1p and human neurofibromin [Source:SGD;Acc:S000005441]
O	YOL082W	ATG19	260	-185.2	4	Receptor protein specific for the cytoplasm-to-vacuole targeting (Cvt) pathway; delivers cargo proteins aminopeptidase I (Lap4p) and alpha-mannosidase (Ams1p) to the phagophore assembly site for packaging into Cvt vesicles [Source:SGD;Acc:S000005442]
O	YOL083C-A	YOL083C-A	1	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028853]
O	YOL083W	ATG34	156	-303	4	Receptor protein involved in selective autophagy during starvation; specifically involved in the transport of cargo protein alpha-mannosidase (Ams1p); Atg19p paralog [Source:SGD;Acc:S000005443]
O	YOL084W	PHM7	148	-441.6	4	Protein of unknown function, expression is regulated by phosphate levels; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery and vacuole [Source:SGD;Acc:S000005444]
O	YOL085C	YOL085C	3	-2.4	2	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOL085W-A [Source:SGD;Acc:S000005445]
O	YOL085W-A	YOL085W-A	2	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF YOL085C [Source:SGD;Acc:S000028708]
O	YOL086C	ADH1	6943	-1908.9	4	Alcohol dehydrogenase, fermentative isozyme active as homo- or heterotetramers; required for the reduction of acetaldehyde to ethanol, the last step in the glycolytic pathway [Source:SGD;Acc:S000005446]
O	YOL086W-A	MHF1	128	-48.1	4	Putative protein of unknown function; mutant in a srs2 mutant background displays MMS hypersensitivity; ortholog of human MHF1, a component of the Fanconi anemia (FA) complex that is involved in maintaining genome stability [Source:SGD;Acc:S000007626]
O	YOL087C	DUF1	702	-438.2	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; deletion mutant is sensitive to various chemicals including phenanthroline, sanguinarine, and nordihydroguaiaretic acid [Source:SGD;Acc:S000005447]
O	YOL088C	MPD2	682	-188.3	4	Member of the protein disulfide isomerase (PDI) family, exhibits chaperone activity; overexpression suppresses the lethality of a pdi1 deletion but does not complement all Pdi1p functions; undergoes oxidation by Ero1p [Source:SGD;Acc:S000005448]
O	YOL089C	HAL9	226	-286.8	4	Putative transcription factor containing a zinc finger; overexpression increases salt tolerance through increased expression of the ENA1 (Na+/Li+ extrusion pump) gene while gene disruption decreases both salt tolerance and ENA1 expression [Source:SGD;Acc:S000005449]
O	YOL090W	MSH2	831	-455.7	4	Protein that forms heterodimers with Msh3p and Msh6p that bind to DNA mismatches to initiate the mismatch repair process; contains a Walker ATP-binding motif required for repair activity; Msh2p-Msh6p binds to and hydrolyzes ATP [Source:SGD;Acc:S000005450]
O	YOL091W	SPO21	45	-33.1	2	Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation [Source:SGD;Acc:S000005451]
O	YOL092W	YPQ1	381	-79.4	4	Putative protein of unknown function; predicted to contain six transmembrane domains and is 58% similar to the uncharacterized ORF YBR147W [Source:SGD;Acc:S000005452]
O	YOL093W	TRM10	430	-197.9	4	tRNA methyltransferase, methylates the N-1 position of guanosine in tRNAs [Source:SGD;Acc:S000005453]
O	YOL094C	RFC4	913	-357.3	4	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon [Source:SGD;Acc:S000005454]
O	YOL095C	HMI1	110	-124.3	4	Mitochondrial inner membrane localized ATP-dependent DNA helicase, required for the maintenance of the mitochondrial genome; not required for mitochondrial transcription; has homology to E. coli helicase uvrD [Source:SGD;Acc:S000005455]
O	YOL096C	COQ3	233	-123.4	4	O-methyltransferase, catalyzes two different O-methylation steps in ubiquinone (Coenzyme Q) biosynthesis; component of a mitochondrial ubiquinone-synthesizing complex; phosphoprotein [Source:SGD;Acc:S000005456]
O	YOL097C	WRS1	2295	-696.7	4	Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA [Source:SGD;Acc:S000005457]
O	YOL097W-A	YOL097W-A	2	-1.4	1	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028854]
O	YOL098C	YOL098C	1264	-649.1	4	Putative metalloprotease [Source:SGD;Acc:S000005458]
O	YOL099C	YOL099C	8	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes [Source:SGD;Acc:S000005459]
O	YOL100W	PKH2	524	-2089.1	4	Serine/threonine protein kinase involved in sphingolipid-mediated signaling pathway that controls endocytosis; activates Ypk1p and Ykr2p, components of signaling cascade required for maintenance of cell wall integrity; redundant with Pkh1p [Source:SGD;Acc:S000005460]
O	YOL101C	IZH4	58	-36.8	4	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family, expression induced by fatty acids and altered zinc levels; deletion reduces sensitivity to excess zinc; possible role in sterol metabolism [Source:SGD;Acc:S000005461]
O	YOL102C	TPT1	337	-113.4	4	tRNA 2'-phosphotransferase, catalyzes the final step in yeast tRNA splicing: the transfer of the 2'-PO(4) from the splice junction to NAD(+) to form ADP-ribose 1''-2''cyclic phosphate and nicotinamide [Source:SGD;Acc:S000005462]
O	YOL103W	ITR2	101	-37.2	4	Myo-inositol transporter with strong similarity to the major myo-inositol transporter Itr1p, member of the sugar transporter superfamily; expressed constitutively [Source:SGD;Acc:S000005463]
O	YOL103W-A	YOL103W-A	4633	-1637.7	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007349]
O	YOL103W-B	YOL103W-B	4966	-2417.6	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007350]
O	YOL104C	NDJ1	9	-2	2	Meiosis-specific telomere protein, required for bouquet formation, effective homolog pairing, ordered cross-over distribution, sister chromatid cohesion at meiotic telomeres, chromosomal segregation and telomere-led rapid prophase movement [Source:SGD;Acc:S000005464]
O	YOL105C	WSC3	9	-6.5	2	Partially redundant sensor-transducer of the stress-activated PKC1-MPK1 signaling pathway involved in maintenance of cell wall integrity; involved in the response to heat shock and other stressors; regulates 1,3-beta-glucan synthesis [Source:SGD;Acc:S000005465]
O	YOL106W	YOL106W	1	-1.2	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005466]
O	YOL107W	YOL107W	108	-80.9	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and colocalizes in a punctate pattern with the early golgi/COPI vesicles; YOL107W is not an essential protein [Source:SGD;Acc:S000005467]
O	YOL108C	INO4	94	-64.2	4	Transcription factor required for derepression of inositol-choline-regulated genes involved in phospholipid synthesis; forms a complex, with Ino2p, that binds the inositol-choline-responsive element through a basic helix-loop-helix domain [Source:SGD;Acc:S000005468]
O	YOL109W	ZEO1	2749	-816.2	4	Peripheral membrane protein of the plasma membrane that interacts with Mid2p; regulates the cell integrity pathway mediated by Pkc1p and Slt2p; the authentic protein is detected in a phosphorylated state in highly purified mitochondria [Source:SGD;Acc:S000005469]
O	YOL110W	SHR5	36	-21.4	2	Subunit of a palmitoyltransferase, composed of Shr5p and Erf2p, that adds a palmitoyl lipid moiety to heterolipidated substrates such as Ras1p and Ras2p through a thioester linkage; palmitoylation is required for Ras2p membrane localization [Source:SGD;Acc:S000005470]
O	YOL111C	MDY2	1776	-176.8	4	Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Get4p; required for efficient mating; involved in shmoo formation and nuclear migration in the pre-zygote; associates with ribosomes [Source:SGD;Acc:S000005471]
O	YOL112W	MSB4	94	-110.6	4	GTPase-activating protein of the Ras superfamily that acts primarily on Sec4p, localizes to the bud site and bud tip, has similarity to Msb3p; msb3 msb4 double mutation causes defects in secretion and actin organization [Source:SGD;Acc:S000005472]
O	YOL113W	SKM1	141	-1221.3	4	Member of the PAK family of serine/threonine protein kinases with similarity to Ste20p and Cla4p; involved in down-regulation of sterol uptake; proposed to be a downstream effector of Cdc42p during polarized growth [Source:SGD;Acc:S000005473]
O	YOL114C	YOL114C	26	-18.8	4	Putative protein of unknown function with similarity to human ICT1 and prokaryotic factors that may function in translation termination; YOL114C is not an essential gene [Source:SGD;Acc:S000005474]
O	YOL115W	PAP2	383	-403.7	4	Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p [Source:SGD;Acc:S000005475]
O	YOL116W	MSN1	170	-195.2	4	Transcriptional activator involved in regulation of invertase and glucoamylase expression, invasive growth and pseudohyphal differentiation, iron uptake, chromium accumulation, and response to osmotic stress; localizes to the nucleus [Source:SGD;Acc:S000005476]
O	YOL117W	RRI2	40	-67.8	4	Subunit of the COP9 signalosome (CSN) complex that cleaves the ubiquitin-like protein Nedd8 from SCF ubiquitin ligases; plays a role in the mating pheromone response [Source:SGD;Acc:S000005477]
O	YOL118C	YOL118C	2	-1.4	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005478]
O	YOL119C	MCH4	163	-61.3	4	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport [Source:SGD;Acc:S000005479]
O	YOL120C	RPL18A	3973	-363.5	4	Protein component of the large (60S) ribosomal subunit, identical to Rpl18Bp and has similarity to rat L18 ribosomal protein; intron of RPL18A pre-mRNA forms stem-loop structures that are a target for Rnt1p cleavage leading to degradation [Source:SGD;Acc:S000005480]
O	YOL121C	RPS19A	4285	-425.2	4	Protein component of the small (40S) ribosomal subunit, required for assembly and maturation of pre-40 S particles; mutations in human RPS19 are associated with Diamond Blackfan anemia; nearly identical to Rps19Bp [Source:SGD;Acc:S000005481]
O	YOL122C	SMF1	178	-82.9	4	Divalent metal ion transporter with a broad specificity for di-valent and tri-valent metals; post-translationally regulated by levels of metal ions; member of the Nramp family of metal transport proteins [Source:SGD;Acc:S000005482]
O	YOL123W	HRP1	2236	-503.3	4	Subunit of cleavage factor I, a five-subunit complex required for the cleavage and polyadenylation of pre-mRNA 3' ends; RRM-containing heteronuclear RNA binding protein and hnRNPA/B family member that binds to poly (A) signal sequences [Source:SGD;Acc:S000005483]
O	YOL124C	TRM11	403	-170.3	4	Catalytic subunit of an adoMet-dependent tRNA methyltransferase complex (Trm11p-Trm112p), required for the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs; contains a THUMP domain and a methyltransferase domain [Source:SGD;Acc:S000005484]
O	YOL125W	TRM13	247	-227.8	4	2'-O-methyltransferase responsible for modification of tRNA at position 4; C-terminal domain has similarity to Rossmann-fold (RFM) superfamily of RNA methyltransferases [Source:SGD;Acc:S000005485]
O	YOL126C	MDH2	806	-643.3	4	Cytoplasmic malate dehydrogenase, one of three isozymes that catalyze interconversion of malate and oxaloacetate; involved in the glyoxylate cycle and gluconeogenesis during growth on two-carbon compounds; interacts with Pck1p and Fbp1 [Source:SGD;Acc:S000005486]
O	YOL127W	RPL25	4338	-460.3	4	Primary rRNA-binding ribosomal protein component of the large (60S) ribosomal subunit, has similarity to E. coli L23 and rat L23a ribosomal proteins; binds to 25S rRNA via a conserved C-terminal motif [Source:SGD;Acc:S000005487]
O	YOL128C	YGK3	49	-1006.9	4	Protein kinase related to mammalian glycogen synthase kinases of the GSK-3 family; GSK-3 homologs (Mck1p, Rim11p, Mrk1p, Ygk3p) are involved in control of Msn2p-dependent transcription of stress responsive genes and in protein degradation [Source:SGD;Acc:S000005488]
O	YOL129W	VPS68	327	-48	4	Vacuolar membrane protein of unknown function involved in vacuolar protein sorting; also detected in the mitochondria [Source:SGD;Acc:S000005489]
O	YOL130W	ALR1	638	-185.9	4	Plasma membrane Mg(2+) transporter, expression and turnover are regulated by Mg(2+) concentration; overexpression confers increased tolerance to Al(3+) and Ga(3+) ions [Source:SGD;Acc:S000005490]
O	YOL131W	YOL131W	1	-1.7	1	Putative protein of unknown function [Source:SGD;Acc:S000005491]
O	YOL132W	GAS4	14	-8.3	2	1,3-beta-glucanosyltransferase, involved with Gas2p in spore wall assembly; has similarity to Gas1p; localizes to the cell wall [Source:SGD;Acc:S000005492]
O	YOL133W	HRT1	432	-131.2	4	RING finger containing subunit of Skp1-Cullin-F-box ubiquitin protein ligases (SCF); required for Gic2p, Far1p, Sic1p and Cln2p degradation; may tether Cdc34p (a ubiquitin conjugating enzyme or E2) and Cdc53p (a cullin) subunits of SCF [Source:SGD;Acc:S000005493]
O	YOL134C	YOL134C	1	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps HRT1, a verified gene that encodes an SCF ubiquitin ligase subunit [Source:SGD;Acc:S000005494]
O	YOL135C	MED7	202	-75.5	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation [Source:SGD;Acc:S000005495]
O	YOL136C	PFK27	57	-34	4	6-phosphofructo-2-kinase, catalyzes synthesis of fructose-2,6-bisphosphate; inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate, expression induced by glucose and sucrose, transcriptional regulation involves protein kinase A [Source:SGD;Acc:S000005496]
O	YOL137W	BSC6	170	-76.9	4	Protein of unknown function containing 8 putative transmembrane seqments; ORF exhibits genomic organization compatible with a translational readthrough-dependent mode of expression [Source:SGD;Acc:S000005497]
O	YOL138C	RTC1	465	-395	4	Subunit of the SEA (Seh1-associated) complex, a coatomer-related complex that associates dynamically with the vacuole; null mutation suppresses cdc13-1 temperature sensitivity; has N-terminal WD-40 repeats and a C-terminal RING motif [Source:SGD;Acc:S000005498]
O	YOL139C	CDC33	2783	-278.2	4	Cytoplasmic mRNA cap binding protein and translation initiation factor eIF4E; the eIF4E-cap complex is responsible for mediating cap-dependent mRNA translation via interactions with translation initiation factor eIF4G (Tif4631p or Tif4632p) [Source:SGD;Acc:S000005499]
O	YOL140W	ARG8	953	-524.2	4	Acetylornithine aminotransferase, catalyzes the fourth step in the biosynthesis of the arginine precursor ornithine [Source:SGD;Acc:S000005500]
O	YOL141W	PPM2	231	-169.4	4	AdoMet-dependent tRNA methyltransferase also involved in methoxycarbonylation; required for the synthesis of wybutosine (yW), a modified guanosine found at the 3'-position adjacent to the anticodon of phe-tRNA; similarity to Ppm1p [Source:SGD;Acc:S000005501]
O	YOL142W	RRP40	600	-360.9	4	Exosome non-catalytic core component; involved in 3'-5' RNA processing and degradation in both the nucleus and the cytoplasm; predicted to contain both S1 and KH RNA binding domains; has similarity to human hRrp40p (EXOSC3) [Source:SGD;Acc:S000005502]
O	YOL143C	RIB4	1697	-360	4	Lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, also known as DMRL synthase); catalyzes synthesis of immediate precursor to riboflavin [Source:SGD;Acc:S000005503]
O	YOL144W	NOP8	1011	-329.2	4	Nucleolar protein required for 60S ribosomal subunit biogenesis [Source:SGD;Acc:S000005504]
O	YOL145C	CTR9	1554	-893.7	4	Component of the Paf1p complex involved in transcription elongation; binds to and modulates the activity of RNA polymerases I and II; required for expression of a subset of genes, including cyclin genes; involved in SER3 repression by helping to mai  SRG1 transcription-dependent nucleosome occupancy; contains TPR repeats [Source:SGD;Acc:S000005505]
O	YOL146W	PSF3	201	-106.8	4	Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery [Source:SGD;Acc:S000005506]
O	YOL147C	PEX11	541	-203.1	4	Peroxisomal membrane protein required for medium-chain fatty acid oxidation and peroxisome proliferation, possibly by inducing membrane curvature; localization regulated by phosphorylation; transcription regulated by Adr1p and Pip2p-Oaf1p [Source:SGD;Acc:S000005507]
O	YOL148C	SPT20	685	-769.9	4	Subunit of the SAGA transcriptional regulatory complex; involved in maintaining the integrity of the complex; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay [Source:SGD;Acc:S000005508]
O	YOL149W	DCP1	685	-135.8	4	Subunit of the Dcp1p-Dcp2p decapping enzyme complex, which removes the 5' cap structure from mRNAs prior to their degradation; enhances the activity of catalytic subunit Dcp2p; regulated by DEAD box protein Dhh1p [Source:SGD;Acc:S000005509]
O	YOL150C	YOL150C	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005510]
O	YOL151W	GRE2	1376	-541.4	4	3-methylbutanal reductase and NADPH-dependent methylglyoxal reductase (D-lactaldehyde dehydrogenase); stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway [Source:SGD;Acc:S000005511]
O	YOL152W	FRE7	106	-103.3	4	Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels [Source:SGD;Acc:S000005512]
O	YOL154W	ZPS1	256	-611	4	Putative GPI-anchored protein; transcription is induced under low-zinc conditions, as mediated by the Zap1p transcription factor, and at alkaline pH [Source:SGD;Acc:S000005514]
O	YOL155C	HPF1	122	-195.2	4	Haze-protective mannoprotein that reduces the particle size of aggregated proteins in white wines [Source:SGD;Acc:S000005515]
O	YOL155W-A	YOL155W-A	0	nf	1	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028855]
O	YOL156W	HXT11	255	-39.7	4	Putative hexose transporter that is nearly identical to Hxt9p, has similarity to major facilitator superfamily (MFS) transporters and is involved in pleiotropic drug resistance [Source:SGD;Acc:S000005516]
O	YOL157C	IMA2	244	-352.6	4	Alpha-glucosidase with specificity for isomaltase, methyl-alpha-glucoside, and palatinose; member of IMA isomaltase family; not required for isomaltose utilization, but Ima2p overexpression allows the ima1 null mutant to grow on isomaltose [Source:SGD;Acc:S000005517]
O	YOL158C	ENB1	161	-74.3	4	Endosomal ferric enterobactin transporter, expressed under conditions of iron deprivation; member of the major facilitator superfamily; expression is regulated by Rcs1p and affected by chloroquine treatment [Source:SGD;Acc:S000005518]
O	YOL159C	YOL159C	23	-20.1	3	Soluble protein of unknown function; deletion mutants are viable and have elevated levels of Ty1 retrotransposition and Ty1 cDNA [Source:SGD;Acc:S000005519]
O	YOL159C-A	YOL159C-A	36	-34.6	4	Protein of unknown function; overexpression affects endocytic protein trafficking; identified by sequence comparison with hemiascomycetous yeast species [Source:SGD;Acc:S000007627]
O	YOL160W	YOL160W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005520]
O	YOL161C	PAU20	1	0	1	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; expression induced by low temperature and also by anaerobic conditions; induced during alcoholic fermentation [Source:SGD;Acc:S000005521]
O	YOL162W	YOL162W	2	-2.1	2	Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family [Source:SGD;Acc:S000005522]
O	YOL163W	YOL163W	5	-1.7	1	Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family [Source:SGD;Acc:S000005523]
O	YOL164W	BDS1	25	-148.6	4	Bacterially-derived sulfatase required for use of alkyl- and aryl-sulfates as sulfur sources [Source:SGD;Acc:S000005524]
O	YOL164W-A	YOL164W-A	0	nf	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028580]
O	YOL165C	AAD15	6	-1.9	1	Putative aryl-alcohol dehydrogenase; similar to P. chrysosporium aryl-alcohol dehydrogenase; mutational analysis has not yet revealed a physiological role [Source:SGD;Acc:S000005525]
O	YOL166C	YOL166C	1	-1.1	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005526]
O	YOL166W-A	YOL166W-A	4	-1.1	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028709]
O	YOR001W	RRP6	1105	-993.2	4	Nuclear exosome exonuclease component; has 3'-5' exonuclease activity; involved in RNA processing, maturation, surveillance, degradation, tethering, and export; has similarity to E. coli RNase D and to human PM-Sc1 100 (EXOSC10); mutant displays red  ranscription elongation in the G-less-based run-on (GLRO) assay [Source:SGD;Acc:S000005527]
O	YOR002W	ALG6	174	-96.8	4	Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease [Source:SGD;Acc:S000005528]
O	YOR003W	YSP3	105	-162.9	4	Putative precursor to the subtilisin-like protease III [Source:SGD;Acc:S000005529]
O	YOR004W	UTP23	685	-198	4	Essential nucleolar protein that is a component of the SSU (small subunit) processome involved in 40S ribosomal subunit biogenesis; has homology to PINc domain protein Fcf1p, although the PINc domain of Utp23p is not required for function [Source:SGD;Acc:S000005530]
O	YOR005C	DNL4	40	-39.6	3	DNA ligase required for nonhomologous end-joining (NHEJ), forms stable heterodimer with required cofactor Lif1p, interacts with Nej1p; involved in meiosis, not essential for vegetative growth [Source:SGD;Acc:S000005531]
O	YOR006C	TSR3	242	-123.5	4	Protein required for correct processing of the 20S pre-rRNA at site D to generate mature 18S rRNA; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000005532]
O	YOR007C	SGT2	2940	-617.6	4	Glutamine-rich cytoplasmic protein that serves as a scaffold for binding Get4/5p and other proteins required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; has similarity to human cochaperone SGT [Source:SGD;Acc:S000005533]
O	YOR008C	SLG1	398	-149.8	4	Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of sec   response [Source:SGD;Acc:S000005534]
O	YOR008C-A	YOR008C-A	2	-4	2	Putative protein of unknown function, includes a potential transmembrane domain; deletion results in slightly lengthened telomeres [Source:SGD;Acc:S000006431]
O	YOR008W-B	YOR008W-B	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007628]
O	YOR009W	TIR4	5	-32.2	4	Cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; expressed under anaerobic conditions and required for anaerobic growth; transcription is also induced by cold shock [Source:SGD;Acc:S000005535]
O	YOR010C	TIR2	6	-5.7	2	Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis [Source:SGD;Acc:S000005536]
O	YOR011W	AUS1	96	-153.7	4	Plasma membrane sterol transporter of the ATP-binding cassette family; required, along with Pdr11p, for uptake of exogenous sterols and their incorporation into the plasma membrane; activity is stimulated by phosphatidylserine; sterol uptake is requ  or anaerobic growth because sterol biosynthesis requires oxygen [Source:SGD;Acc:S000005537]
O	YOR011W-A	YOR011W-A	0	nf	1	Putative protein of unknown function [Source:SGD;Acc:S000028581]
O	YOR012W	YOR012W	1	-1.3	1	Putative protein of unknown function [Source:SGD;Acc:S000005538]
O	YOR013W	IRC11	9	-2.4	2	Dubious opening reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YOR012C; null mutant displays increased levels of spontaneous Rad52 foci [Source:SGD;Acc:S000005539]
O	YOR014W	RTS1	1064	-943.6	4	B-type regulatory subunit of protein phosphatase 2A (PP2A); Rts1p and Cdc55p are alternative regulatory subunits for PP2A; PP2A-Rts1p protects cohesin when recruited by Sgo1p to the pericentromere; highly enriched at centromeres in absence of Cdc55p  log of the mammalian B' subunit of PP2A [Source:SGD;Acc:S000005540]
O	YOR015W	YOR015W	3	-0.5	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005541]
O	YOR016C	ERP4	507	-176.7	4	Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport [Source:SGD;Acc:S000005542]
O	YOR017W	PET127	234	-264.4	4	Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane [Source:SGD;Acc:S000005543]
O	YOR018W	ROD1	794	-318	4	Membrane protein that binds the ubiquitin ligase Rsp5p via its 2 PY motifs; overexpression confers resistance to the GST substrate o-dinitrobenzene,zinc, and calcium; proposed to regulate the endocytosis of plasma membrane proteins [Source:SGD;Acc:S000005544]
O	YOR019W	YOR019W	78	-79.3	2	Protein of unknown function that may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000005545]
O	YOR020C	HSP10	2490	-246	4	Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES [Source:SGD;Acc:S000005546]
O	YOR020W-A	YOR020W-A	404	-47.6	4	Putative protein of unknown function, conserved in A. gossypii; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000028526]
O	YOR021C	SFM1	1347	-220.7	4	Putative protein of unknown function; YOR021C is not an essential gene; predicted to be involved in rRNA processing and ribosome biogenesis and in biopolymer catabolism [Source:SGD;Acc:S000005547]
O	YOR022C	YOR022C	261	-273.1	4	Protein with similarity to bovine phospholipase A1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005548]
O	YOR023C	AHC1	274	-141.8	4	Subunit of the Ada histone acetyltransferase complex, required for structural integrity of the complex [Source:SGD;Acc:S000005549]
O	YOR024W	YOR024W	1	0	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005550]
O	YOR025W	HST3	62	-25.2	3	Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst4p in telomeric silencing, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism [Source:SGD;Acc:S000005551]
O	YOR026W	BUB3	125	-246.5	4	Kinetochore checkpoint WD40 repeat protein that localizes to kinetochores during prophase and metaphase, delays anaphase in the presence of unattached kinetochores; forms complexes with Mad1p-Bub1p and with Cdc20p, binds Mad2p and Mad3p [Source:SGD;Acc:S000005552]
O	YOR027W	STI1	3350	-1149.6	4	Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop [Source:SGD;Acc:S000005553]
O	YOR028C	CIN5	129	-55.5	4	Basic leucine zipper (bZIP) transcription factor of the yAP-1 family; physically interacts with the Tup1-Cyc8 complex and recruits Tup1p to its targets; mediates pleiotropic drug resistance and salt tolerance; nuclearly localized under oxidative str  d sequestered in the cytoplasm by Lot6p under reducing conditions [Source:SGD;Acc:S000005554]
O	YOR029W	YOR029W	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005555]
O	YOR030W	DFG16	63	-20.4	4	Probable multiple transmembrane protein, involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; required for accumulation of processed Rim101p [Source:SGD;Acc:S000005556]
O	YOR031W	CRS5	32	-36.7	4	Copper-binding metallothionein, required for wild-type copper resistance [Source:SGD;Acc:S000005557]
O	YOR032C	HMS1	44	-90.9	4	Basic helix-loop-helix (bHLH) protein with similarity to myc-family transcription factors; overexpression confers hyperfilamentous growth and suppresses the pseudohyphal filamentation defect of a diploid mep1 mep2 homozygous null mutant [Source:SGD;Acc:S000005558]
O	YOR032W-A	YOR032W-A	0	nf	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028710]
O	YOR033C	EXO1	71	-60.6	4	5'-3' exonuclease and flap-endonuclease involved in recombination, double-strand break repair and DNA mismatch repair; member of the Rad2p nuclease family, with conserved N and I nuclease domains [Source:SGD;Acc:S000005559]
O	YOR034C	AKR2	172	-142.4	4	Ankyrin repeat-containing protein similar to Akr1p; member of a family of putative palmitoyltransferases containing an Asp-His-His-Cys-cysteine rich (DHHC-CRD) domain; possibly involved in constitutive endocytosis of Ste3p [Source:SGD;Acc:S000005560]
O	YOR034C-A	YOR034C-A	3	-1.9	1	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028856]
O	YOR035C	SHE4	524	-312.6	4	Protein containing a UCS (UNC-45/CRO1/SHE4) domain, binds to myosin motor domains to regulate myosin function; involved in endocytosis, polarization of the actin cytoskeleton, and asymmetric mRNA localization [Source:SGD;Acc:S000005561]
O	YOR036W	PEP12	286	-254.4	4	Target membrane receptor (t-SNARE) for vesicular intermediates traveling between the Golgi apparatus and the vacuole; controls entry of biosynthetic, endocytic, and retrograde traffic into the prevacuolar compartment; syntaxin [Source:SGD;Acc:S000005562]
O	YOR037W	CYC2	120	-121.4	4	Mitochondrial peripheral inner membrane protein, contains a FAD cofactor in a domain exposed in the intermembrane space; exhibits redox activity in vitro; likely participates in ligation of heme to acytochromes c and c1 (Cyc1p and Cyt1p) [Source:SGD;Acc:S000005563]
O	YOR038C	HIR2	517	-258.2	4	Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p [Source:SGD;Acc:S000005564]
O	YOR039W	CKB2	928	-155.9	4	Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase [Source:SGD;Acc:S000005565]
O	YOR040W	GLO4	191	-175.2	4	Mitochondrial glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate [Source:SGD;Acc:S000005566]
O	YOR041C	YOR041C	2	0	1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the uncharacterized gene CUE5; deletion in cyr1 mutant results in loss of stress resistance [Source:SGD;Acc:S000005567]
O	YOR042W	CUE5	1644	-484.2	4	Protein containing a CUE domain that binds ubiquitin, which may facilitate intramolecular monoubiquitination; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000005568]
O	YOR043W	WHI2	727	-244.3	4	Protein required, with binding partner Psr1p, for full activation of the general stress response, possibly through Msn2p dephosphorylation; regulates growth during the diauxic shift; negative regulator of G1 cyclin expression [Source:SGD;Acc:S000005569]
O	YOR044W	IRC23	7	-37.6	2	Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000005570]
O	YOR045W	TOM6	595	-106.5	4	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex [Source:SGD;Acc:S000005571]
O	YOR046C	DBP5	2434	-575.2	4	Cytoplasmic ATP-dependent RNA helicase of the DEAD-box family; involved in mRNA export from the nucleus; involved in translation termination; ATP/ADP cycling is regulated by Gle1p and Nup159p [Source:SGD;Acc:S000005572]
O	YOR047C	STD1	19	-11.1	3	Protein involved in control of glucose-regulated gene expression; interacts with kinase Snf1p, glucose sensors Snf3p and Rgt2p, TATA-binding Spt15p; regulator of transcription factor Rgt1p; interactions with Pma1p appear to propagate [GAR+] [Source:SGD;Acc:S000005573]
O	YOR048C	RAT1	1146	-449.1	4	Nuclear 5' to 3' single-stranded RNA exonuclease, involved in RNA metabolism, including rRNA and snRNA processing as well as poly (A+) dependent and independent mRNA transcription termination [Source:SGD;Acc:S000005574]
O	YOR049C	RSB1	16	-46.7	4	Suppressor of sphingoid long chain base (LCB) sensitivity of an LCB-lyase mutation; putative integral membrane transporter or flippase that may transport LCBs from the cytoplasmic side toward the extracytoplasmic side of the membrane [Source:SGD;Acc:S000005575]
O	YOR050C	YOR050C	2	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutation is viable [Source:SGD;Acc:S000005576]
O	YOR051C	ETT1	1434	-425	4	Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough [Source:SGD;Acc:S000005577]
O	YOR052C	TMC1	508	-82.6	4	Nuclear protein of unknown function; expression induced by nitrogen limitation in a GLN3, GAT1-independent manner and by weak acid; transcriptionally regulated by Rpn4p along with proteasome subunit genes; putative ortholog of human AIRAP, which sti  s proteasome activity in response to arsenic [Source:SGD;Acc:S000005578]
O	YOR053W	YOR053W	5	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VHS3/YOR054C [Source:SGD;Acc:S000005579]
O	YOR054C	VHS3	739	-433	4	Negative regulatory subunit of protein phosphatase 1 Ppz1p and also a subunit of the phosphopantothenoylcysteine decarboxylase (PPCDC; Cab3p, Sis2p, Vhs3p) complex, which catalyzes the third step of coenzyme A biosynthesis [Source:SGD;Acc:S000005580]
O	YOR055W	YOR055W	5	-1.8	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005581]
O	YOR056C	NOB1	979	-195.4	4	Essential nuclear protein involved in proteasome maturation and synthesis of 40S ribosomal subunits; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA [Source:SGD;Acc:S000005582]
O	YOR057W	SGT1	871	-313.9	4	Cochaperone protein; regulates activity of adenylyl cyclase Cyr1p; involved in kinetochore complex assembly; associates with the SCF (Skp1p/Cdc53p/F box protein) ubiquitin ligase complex; acts as a linker between Skp1p and HSP90 complexes [Source:SGD;Acc:S000005583]
O	YOR058C	ASE1	89	-51	4	Mitotic spindle midzone localized microtubule-associated protein (MAP) family member; required for spindle elongation and stabilization; undergoes cell cycle-regulated degradation by anaphase promoting complex; potential Cdc28p substrate [Source:SGD;Acc:S000005584]
O	YOR059C	LPL1	93	-195	4	Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor RPN4 [Source:SGD;Acc:S000005585]
O	YOR060C	SLD7	28	-27.6	3	Protein with a role in chromosomal DNA replication; interacts with Sld3p and reduces its affinity for Cdc45p; deletion mutant has aberrant mitochondria [Source:SGD;Acc:S000005586]
O	YOR061W	CKA2	1583	-654.3	4	Alpha' catalytic subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase [Source:SGD;Acc:S000005587]
O	YOR062C	YOR062C	11	-11.3	2	Protein of unknown function; similar to YKR075Cp and Reg1p; expression regulated by glucose and Rgt1p; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000005588]
O	YOR063W	RPL3	5117	-1321.1	4	Protein component of the large (60S) ribosomal subunit, has similarity to E. coli L3 and rat L3 ribosomal proteins; involved in the replication and maintenance of killer double stranded RNA virus [Source:SGD;Acc:S000005589]
O	YOR064C	YNG1	43	-44.6	4	Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3, has similarity to the human tumor suppressor ING1 [Source:SGD;Acc:S000005590]
O	YOR065W	CYT1	1192	-690.3	4	Cytochrome c1, component of the mitochondrial respiratory chain; expression is regulated by the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex [Source:SGD;Acc:S000005591]
O	YOR066W	MSA1	260	-83.5	4	Activator of G1-specific transcription factors, MBF and SBF; involved in regulation of the timing of G1-specific gene transcription and cell cycle initiation; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation [Source:SGD;Acc:S000005592]
O	YOR067C	ALG8	134	-136.7	4	Glucosyl transferase, involved in N-linked glycosylation; adds glucose to the dolichol-linked oligosaccharide precursor prior to transfer to protein during lipid-linked oligosaccharide biosynthesis; similar to Alg6p [Source:SGD;Acc:S000005593]
O	YOR068C	VAM10	4	-1.5	1	Protein involved in vacuole morphogenesis; acts at an early step of homotypic vacuole fusion that is required for vacuole tethering [Source:SGD;Acc:S000005594]
O	YOR069W	VPS5	743	-499.8	4	Nexin-1 homolog required for localizing membrane proteins from a prevacuolar/late endosomal compartment back to the late Golgi apparatus; structural component of the retromer membrane coat complex; forms a retromer subcomplex with Vps17p [Source:SGD;Acc:S000005595]
O	YOR070C	GYP1	384	-296.3	4	Cis-golgi GTPase-activating protein (GAP) for the Rab family members Ypt1p (in vivo) and for Ypt1p, Sec4p, Ypt7p, and Ypt51p (in vitro); involved in vesicle docking and fusion [Source:SGD;Acc:S000005596]
O	YOR071C	NRT1	96	-71.5	4	High-affinity nicotinamide riboside transporter; also transports thiamine with low affinity; shares sequence similarity with Thi7p and Thi72p; proposed to be involved in 5-fluorocytosine sensitivity [Source:SGD;Acc:S000005597]
O	YOR072W	YOR072W	1	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the dubious gene YOR072W-A; diploid deletion strains are methotrexate, paraquat and wortmannin sensitive [Source:SGD;Acc:S000005598]
O	YOR072W-A	YOR072W-A	2	-2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR072W; originally identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028582]
O	YOR072W-B	YOR072W-B	1	-2.5	2	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028516]
O	YOR073W	SGO1	30	-26.8	4	Component of the spindle checkpoint, involved in sensing lack of tension on mitotic chromosomes; protects centromeric Rec8p at meiosis I; required for accurate chromosomal segregation at meiosis II and for mitotic chromosome stability [Source:SGD;Acc:S000005599]
O	YOR073W-A	YOR073W-A	2	-3.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CDC21/YOR074C; identified by RT-PCR [Source:SGD;Acc:S000028583]
O	YOR074C	CDC21	917	-322.7	4	Thymidylate synthase, required for de novo biosynthesis of pyrimidine deoxyribonucleotides; expression is induced at G1/S [Source:SGD;Acc:S000005600]
O	YOR075W	UFE1	162	-203.2	4	t-SNARE required for retrograde vesicular traffic and homotypic ER membrane fusion; forms a complex with the SNAREs Sec22p, Sec20p and Use1p to mediate fusion of Golgi-derived vesicles at the ER [Source:SGD;Acc:S000005601]
O	YOR076C	SKI7	330	-944.9	4	Coupling protein that mediates interactions between the Ski complex and the cytoplasmic exosome during 3'-5' RNA degradation; eRF3-like domain targets nonstop mRNA for degradation; null mutants have superkiller phenotype [Source:SGD;Acc:S000005602]
O	YOR077W	RTS2	132	-134.9	4	Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication [Source:SGD;Acc:S000005603]
O	YOR078W	BUD21	643	-105.8	4	Component of small ribosomal subunit (SSU) processosome that contains U3 snoRNA; originally isolated as bud-site selection mutant that displays a random budding pattern [Source:SGD;Acc:S000005604]
O	YOR079C	ATX2	18	-47.2	4	Golgi membrane protein involved in manganese homeostasis; overproduction suppresses the sod1 (copper, zinc superoxide dismutase) null mutation [Source:SGD;Acc:S000005605]
O	YOR080W	DIA2	66	-131.3	4	Origin-binding F-box protein; forms an SCF ubiquitin ligase complex with Skp1p and Cdc53p; plays a role in DNA replication; plays a role in transcription; required for correct assembly of RSC complex, correct RSC-mediated transcription regulation, a  rect nucleosome positioning; involved in invasive and pseudohyphal growth [Source:SGD;Acc:S000005606]
O	YOR081C	TGL5	314	-262.6	4	Bifunctional enzyme with triacylglycerol lipase and lysophosphatidic acid acyltransferase activity; involved in triacylglycerol mobilization; localizes to lipid particles; potential Cdc28p substrate [Source:SGD;Acc:S000005607]
O	YOR082C	YOR082C	2	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene YOR083W [Source:SGD;Acc:S000005608]
O	YOR083W	WHI5	307	-176.2	4	Repressor of G1 transcription that binds to SCB binding factor (SBF) at SCB target promoters in early G1; phosphorylation of Whi5p by the CDK, Cln3p/Cdc28p relieves repression and promoter binding by Whi5; periodically expressed in G1 [Source:SGD;Acc:S000005609]
O	YOR084W	LPX1	176	-255.7	4	Oleic acid-inducible, peroxisomal matrix localized lipase; transcriptionally activated by Yrm1p along with genes involved in multidrug resistance; peroxisomal import is dependent on the PTS1 receptor, Pex5p and on self-interaction [Source:SGD;Acc:S000005610]
O	YOR085W	OST3	808	-121.8	4	Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins [Source:SGD;Acc:S000005611]
O	YOR086C	TCB1	1957	-1108.4	4	Lipid-binding protein containing three calcium and lipid binding domains; non-tagged protein localizes to mitochondria and GFP-fusion protein localizes to the cell periphery; C-termini of Tcb1p, Tcb2p and Tcb3p interact [Source:SGD;Acc:S000005612]
O	YOR087W	YVC1	430	-220.2	4	Vacuolar cation channel, mediates release of Ca(2+) from the vacuole in response to hyperosmotic shock [Source:SGD;Acc:S000005613]
O	YOR089C	VPS21	1498	-367	4	Rab family GTPase required for endocytic transport and for sorting of vacuolar hydrolases; localized in endocytic intermediates; detected in mitochondria; geranylgeranylation required for membrane association; mammalian Rab5 homolog [Source:SGD;Acc:S000005615]
O	YOR090C	PTC5	656	-1520.3	4	Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p [Source:SGD;Acc:S000005616]
O	YOR091W	TMA46	1391	-175.2	4	Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p [Source:SGD;Acc:S000005617]
O	YOR092W	ECM3	232	-78.9	4	Non-essential protein of unknown function; involved in signal transduction and the genotoxic response; induced rapidly in response to treatment with 8-methoxypsoralen and UVA irradiation [Source:SGD;Acc:S000005618]
O	YOR093C	YOR093C	459	-507.8	4	Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents [Source:SGD;Acc:S000005619]
O	YOR094W	ARF3	325	-103.1	4	Glucose-repressible ADP-ribosylation factor, GTPase of the Ras superfamily involved in development of polarity; also has mRNA binding activity [Source:SGD;Acc:S000005620]
O	YOR095C	RKI1	1437	-267	4	Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis [Source:SGD;Acc:S000005621]
O	YOR096W	RPS7A	4873	-567.8	4	Protein component of the small (40S) ribosomal subunit, nearly identical to Rps7Bp; interacts with Kti11p; deletion causes hypersensitivity to zymocin; has similarity to rat S7 and Xenopus S8 ribosomal proteins [Source:SGD;Acc:S000005622]
O	YOR097C	YOR097C	87	-97.7	4	Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen; YOR097C is not an essential gene [Source:SGD;Acc:S000005623]
O	YOR098C	NUP1	1370	-708.6	4	Nuclear pore complex (NPC) subunit, involved in protein import/export and in export of RNAs, possible karyopherin release factor that accelerates release of karyopherin-cargo complexes after transport across NPC; potential Cdc28p substrate [Source:SGD;Acc:S000005624]
O	YOR099W	KTR1	1499	-442.6	4	Alpha-1,2-mannosyltransferase involved in O- and N-linked protein glycosylation; type II membrane protein; member of the KRE2/MNT1 mannosyltransferase family [Source:SGD;Acc:S000005625]
O	YOR100C	CRC1	280	-319.4	4	Mitochondrial inner membrane carnitine transporter, required for carnitine-dependent transport of acetyl-CoA from peroxisomes to mitochondria during fatty acid beta-oxidation [Source:SGD;Acc:S000005626]
O	YOR101W	RAS1	1272	-317.1	4	GTPase involved in G-protein signaling in the adenylate cyclase activating pathway, plays a role in cell proliferation; localized to the plasma membrane; homolog of mammalian RAS proto-oncogenes [Source:SGD;Acc:S000005627]
O	YOR102W	YOR102W	2	-2.3	2	Dubious open reading frame, unlikely to encode a functional protein; extensively overlaps essential OST2 gene encoding a subunit of the ER lumen oligosaccharyltransferase complex [Source:SGD;Acc:S000005628]
O	YOR103C	OST2	697	-123.3	4	Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins [Source:SGD;Acc:S000005629]
O	YOR104W	PIN2	294	-164.5	4	Protein that induces appearance of [PIN+] prion when overproduced; predicted to be palmitoylated [Source:SGD;Acc:S000005630]
O	YOR105W	YOR105W	4	-2.5	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005631]
O	YOR106W	VAM3	211	-157.6	4	Syntaxin-like vacuolar t-SNARE that functions with Vam7p in vacuolar protein trafficking; mediates docking/fusion of late transport intermediates with the vacuole; has an acidic di-leucine sorting signal and C-terminal transmembrane region [Source:SGD;Acc:S000005632]
O	YOR107W	RGS2	14	-16	2	Negative regulator of glucose-induced cAMP signaling; directly activates the GTPase activity of the heterotrimeric G protein alpha subunit Gpa2p [Source:SGD;Acc:S000005633]
O	YOR108C-A	YOR108C-A	0	nf	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028711]
O	YOR108W	LEU9	2298	-878.3	4	Alpha-isopropylmalate synthase II (2-isopropylmalate synthase), catalyzes the first step in the leucine biosynthesis pathway; the minor isozyme, responsible for the residual alpha-IPMS activity detected in a leu4 null mutant [Source:SGD;Acc:S000005634]
O	YOR109W	INP53	1474	-2523.3	4	Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains [Source:SGD;Acc:S000005635]
O	YOR110W	TFC7	568	-182.9	4	One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA globular domain of TFIIIC that binds DNA at the BoxA promoter sites of tRNA and similar genes [Source:SGD;Acc:S000005636]
O	YOR111W	YOR111W	307	-99.1	4	Putative protein of unknown function [Source:SGD;Acc:S000005637]
O	YOR112W	CEX1	980	-469.7	4	Cytoplasmic component of the nuclear aminoacylation-dependent tRNA export pathway; interacts with nuclear pore component Nup116p; copurifies with tRNA export receptors Los1p and Msn5p, as well as eIF-1a and the RAN GTPase Gsp1p [Source:SGD;Acc:S000005638]
O	YOR113W	AZF1	307	-289.5	4	Zinc-finger transcription factor, involved in induction of CLN3 transcription in response to glucose; genetic and physical interactions indicate a possible role in mitochondrial transcription or genome maintenance [Source:SGD;Acc:S000005639]
O	YOR114W	YOR114W	12	-5.8	2	Putative protein of unknown function; null mutant is viable [Source:SGD;Acc:S000005640]
O	YOR115C	TRS33	511	-220.3	4	One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic [Source:SGD;Acc:S000005641]
O	YOR116C	RPO31	1150	-943.8	4	RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21 [Source:SGD;Acc:S000005642]
O	YOR117W	RPT5	2458	-576.2	4	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1 [Source:SGD;Acc:S000005643]
O	YOR118W	RTC5	338	-239.5	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; null mutation suppresses cdc13-1 temperature sensitivity [Source:SGD;Acc:S000005644]
O	YOR119C	RIO1	483	-565.9	4	Essential serine kinase involved in cell cycle progression and processing of the 20S pre-rRNA into mature 18S rRNA [Source:SGD;Acc:S000005645]
O	YOR120W	GCY1	1720	-365.4	4	Putative NADP(+) coupled glycerol dehydrogenase, proposed to be involved in an alternative pathway for glycerol catabolism; also has mRNA binding activity; member of the aldo-keto reductase (AKR) family [Source:SGD;Acc:S000005646]
O	YOR121C	YOR121C	2	-1.7	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GCY1/YOR120W [Source:SGD;Acc:S000005647]
O	YOR122C	PFY1	1895	-236	4	Profilin, binds actin, phosphatidylinositol 4,5-bisphosphate, and polyproline regions; involved in cytoskeleton organization; required for normal timing of actin polymerization in response to thermal stress [Source:SGD;Acc:S000005648]
O	YOR123C	LEO1	1147	-624	4	Component of the Paf1 complex; which associates with RNA polymerase II and is involved in histone methylation; plays a role in regulating Ty1 transposition; involved in transcription elongation as demonstrated by the G-less-based run-on (GLRO) assay [Source:SGD;Acc:S000005649]
O	YOR124C	UBP2	1077	-864	4	Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; interacts with Rsp5p and is required for MVB sorting of membrane proteins; can cleave polyubiquitin and has isopeptidase activity [Source:SGD;Acc:S000005650]
O	YOR125C	CAT5	277	-125.4	4	Protein required for ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes; required for gluconeogenic gene activation [Source:SGD;Acc:S000005651]
O	YOR126C	IAH1	425	-136.4	4	Isoamyl acetate-hydrolyzing esterase, required in balance with alcohol acetyltransferase to maintain optimal amounts of isoamyl acetate, which is particularly important in sake brewing [Source:SGD;Acc:S000005652]
O	YOR127W	RGA1	348	-369.3	4	GTPase-activating protein for the polarity-establishment protein Cdc42p; implicated in control of septin organization, pheromone response, and haploid invasive growth [Source:SGD;Acc:S000005653]
O	YOR128C	ADE2	1802	-965.8	4	Phosphoribosylaminoimidazole carboxylase, catalyzes a step in the 'de novo' purine nucleotide biosynthetic pathway; red pigment accumulates in mutant cells deprived of adenine [Source:SGD;Acc:S000005654]
O	YOR129C	AFI1	95	-174.7	4	Arf3p polarization-specific docking factor, required for the polarized distribution of the ADP-ribosylation factor, Arf3p; participates in polarity development and maintenance of a normal haploid budding pattern; interacts with Cnm7p [Source:SGD;Acc:S000005655]
O	YOR130C	ORT1	186	-111.6	4	Ornithine transporter of the mitochondrial inner membrane, exports ornithine from mitochondria as part of arginine biosynthesis; human ortholog is associated with hyperammonaemia-hyperornithinaemia-homocitrullinuria (HHH) syndrome [Source:SGD;Acc:S000005656]
O	YOR131C	YOR131C	616	-190	4	Putative protein of unknown function; non-essential gene; overexpression causes a cell cycle delay or arrest [Source:SGD;Acc:S000005657]
O	YOR132W	VPS17	647	-360.9	4	Subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde protein transport; peripheral membrane protein that assembles onto the membrane with Vps5p to promote vesicle formation [Source:SGD;Acc:S000005658]
O	YOR133W	EFT1	6190	-3703.6	4	Elongation factor 2 (EF-2), also encoded by EFT2; catalyzes ribosomal translocation during protein synthesis; contains diphthamide, the unique posttranslationally modified histidine residue specifically ADP-ribosylated by diphtheria toxin [Source:SGD;Acc:S000005659]
O	YOR134W	BAG7	46	-30	4	Rho GTPase activating protein (RhoGAP), stimulates the intrinsic GTPase activity of Rho1p, which plays a role in actin cytoskeleton organization and control of cell wall synthesis; structurally and functionally related to Sac7p [Source:SGD;Acc:S000005660]
O	YOR135C	IRC14	10	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YOR136W; null mutant displays increased levels of spontaneous Rad52 foci [Source:SGD;Acc:S000005661]
O	YOR136W	IDH2	2843	-634.1	4	Subunit of mitochondrial NAD(+)-dependent isocitrate dehydrogenase, which catalyzes the oxidation of isocitrate to alpha-ketoglutarate in the TCA cycle; phosphorylated [Source:SGD;Acc:S000005662]
O	YOR137C	SIA1	28	-60.5	3	Protein of unassigned function involved in activation of the Pma1p plasma membrane H+-ATPase by glucose [Source:SGD;Acc:S000005663]
O	YOR138C	RUP1	656	-398.3	4	Protein involved in regulation of Rsp5p, which is an essential HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain [Source:SGD;Acc:S000005664]
O	YOR139C	YOR139C	2	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SFL1/YOR140W [Source:SGD;Acc:S000005665]
O	YOR140W	SFL1	448	-176.8	4	Transcriptional repressor and activator; involved in repression of flocculation-related genes, and activation of stress responsive genes; negatively regulated by cAMP-dependent protein kinase A subunit Tpk2p [Source:SGD;Acc:S000005666]
O	YOR141C	ARP8	714	-3218.7	4	Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity [Source:SGD;Acc:S000005667]
O	YOR142W	LSC1	2322	-599.5	4	Alpha subunit of succinyl-CoA ligase, which is a mitochondrial enzyme of the TCA cycle that catalyzes the nucleotide-dependent conversion of succinyl-CoA to succinate; phosphorylated [Source:SGD;Acc:S000005668]
O	YOR142W-A	YOR142W-A	4514	-1620.1	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007351]
O	YOR142W-B	YOR142W-B	4884	-2251.8	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007352]
O	YOR143C	THI80	528	-189.9	4	Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate) [Source:SGD;Acc:S000005669]
O	YOR144C	ELG1	162	-91.6	4	Subunit of an alternative replication factor C complex important for DNA replication and genome integrity; suppresses spontaneous DNA damage; involved in homologous recombination-mediated repair and telomere homeostasis [Source:SGD;Acc:S000005670]
O	YOR145C	PNO1	1183	-160.6	4	Essential nucleolar protein required for pre-18S rRNA processing, interacts with Dim1p, an 18S rRNA dimethyltransferase, and also with Nob1p, which is involved in proteasome biogenesis; contains a KH domain [Source:SGD;Acc:S000005671]
O	YOR146W	YOR146W	3	-2.9	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene PNO1/YOR145C [Source:SGD;Acc:S000005672]
O	YOR147W	MDM32	99	-99.2	4	Mitochondrial inner membrane protein with similarity to Mdm31p, required for normal mitochondrial morphology and inheritance; interacts genetically with MMM1, MDM10, MDM12, and MDM34 [Source:SGD;Acc:S000005673]
O	YOR148C	SPP2	120	-81.1	4	Essential protein that promotes the first step of splicing and is required for the final stages of spliceosome maturation; interacts with Prp2p, which may release Spp2p from the spliceosome following the first cleavage reaction [Source:SGD;Acc:S000005674]
O	YOR149C	SMP3	31	-39.9	4	Alpha 1,2-mannosyltransferase involved in glycosyl phosphatidyl inositol (GPI) biosynthesis; required for addition of the fourth, side branching mannose to the GPI core structure [Source:SGD;Acc:S000005675]
O	YOR150W	MRPL23	321	-115.2	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000005676]
O	YOR151C	RPB2	2422	-1785.7	4	RNA polymerase II second largest subunit B150, part of central core; similar to bacterial beta subunit [Source:SGD;Acc:S000005677]
O	YOR152C	YOR152C	211	-155.6	4	Putative protein of unknown function; YOR152C is not an essential gene [Source:SGD;Acc:S000005678]
O	YOR153W	PDR5	2492	-2240.3	4	Plasma membrane ATP-binding cassette (ABC) transporter, multidrug transporter actively regulated by Pdr1p; also involved in steroid transport, cation resistance, and cellular detoxification during exponential growth [Source:SGD;Acc:S000005679]
O	YOR154W	SLP1	122	-93.4	4	Integral membrane protein of unknown function; member of the SUN-like family of proteins; genetic interactions suggest a role in folding of ER membrane proteins [Source:SGD;Acc:S000005680]
O	YOR155C	ISN1	595	-281.5	4	Inosine 5'-monophosphate (IMP)-specific 5'-nucleotidase, catalyzes the breakdown of IMP to inosine, does not show similarity to known 5'-nucleotidases from other organisms [Source:SGD;Acc:S000005681]
O	YOR156C	NFI1	60	-54.3	3	SUMO E3 ligase, catalyzes the covalent attachment of SUMO (Smt3p) to proteins; primary E3 ligase for Sir4p; sumoylates Yku70p/Yku80p and Sir4p in vivo to promote chromatin anchoring; promotes telomere anchoring to the nuclear envelope; involved in m  ance of proper telomere length [Source:SGD;Acc:S000005682]
O	YOR157C	PUP1	1245	-189.8	4	Beta 2 subunit of the 20S proteasome; endopeptidase with trypsin-like activity that cleaves after basic residues; synthesized as a proprotein before being proteolytically processed for assembly into 20S particle; human homolog is subunit Z [Source:SGD;Acc:S000005683]
O	YOR158W	PET123	622	-107	4	Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator [Source:SGD;Acc:S000005684]
O	YOR159C	SME1	61	-44.2	4	Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E [Source:SGD;Acc:S000005685]
O	YOR160W	MTR10	456	-352.2	4	Nuclear import receptor, mediates the nuclear localization of proteins involved in mRNA-nucleus export; promotes dissociation of mRNAs from the nucleus-cytoplasm mRNA shuttling protein Npl3p; required for retrograde import of mature tRNAs [Source:SGD;Acc:S000005686]
O	YOR161C	PNS1	196	-72.7	4	Protein of unknown function; has similarity to Torpedo californica tCTL1p, which is postulated to be a choline transporter, neither null mutation nor overexpression affects choline transport [Source:SGD;Acc:S000005687]
O	YOR161C-C	YOR161C-C	0	nf	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028712]
O	YOR161W-A	YOR161W-A	1	-1.3	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028713]
O	YOR161W-B	YOR161W-B	3	-2.1	2	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028714]
O	YOR162C	YRR1	100	-93	4	Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes [Source:SGD;Acc:S000005688]
O	YOR163W	DDP1	731	-153.3	4	Polyphosphate phosphatase; hydrolyzes diphosphorylated inositol polyphosphates and diadenosine polyphosphates; has high specificity for diadenosine hexa- and pentaphosphates; exhibits endopolyphosphatase activity with a high affinity for polyphospha  n activity also observed for its human DIPP homologs; member of the MutT family of nucleotide hydrolases [Source:SGD;Acc:S000005689]
O	YOR164C	GET4	1284	-381.2	4	Protein with a role in insertion of tail-anchored proteins into the ER membrane; forms a complex with Mdy2p; highly conserved across species and homologous to human gene C7orf20 [Source:SGD;Acc:S000005690]
O	YOR165W	SEY1	1254	-528.8	4	GTPase with a role in ER morphology; interacts physically and genetically with Yop1p and Rtn1p; possible functional ortholog of mammalian atlastins, defects in which cause a form of hereditary spastic paraplegia; homolog of Arabidopsis RHD3 [Source:SGD;Acc:S000005691]
O	YOR166C	SWT1	139	-140	4	RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain [Source:SGD;Acc:S000005692]
O	YOR167C	RPS28A	2586	-172	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps28Bp and has similarity to rat S28 ribosomal protein [Source:SGD;Acc:S000005693]
O	YOR168W	GLN4	2530	-1169.3	4	Glutamine tRNA synthetase, monomeric class I tRNA synthetase that catalyzes the specific glutaminylation of tRNA(Glu); N-terminal domain proposed to be involved in enzyme-tRNA interactions [Source:SGD;Acc:S000005694]
O	YOR169C	YOR169C	5	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W [Source:SGD;Acc:S000005695]
O	YOR170W	YOR170W	4	-2.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene LCB4 [Source:SGD;Acc:S000005696]
O	YOR171C	LCB4	955	-1312.4	4	Sphingoid long-chain base kinase, responsible for synthesis of long-chain base phosphates, which function as signaling molecules, regulates synthesis of ceramide from exogenous long-chain bases, localizes to the Golgi and late endosomes [Source:SGD;Acc:S000005697]
O	YOR172W	YRM1	37	-65.5	4	Zn2-Cys6 zinc-finger transcription factor that activates genes involved in multidrug resistance; paralog of Yrr1p, acting on an overlapping set of target genes [Source:SGD;Acc:S000005698]
O	YOR173W	DCS2	1037	-421.5	4	Non-essential, stress induced regulatory protein; modulates m7G-oligoribonucleotide metabolism; inhibits Dcs1p; regulated by Msn2p, Msn4p, and the Ras-cAMP-cAPK signaling pathway; mutant has increased aneuploidy tolerance [Source:SGD;Acc:S000005699]
O	YOR174W	MED4	374	-206	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation [Source:SGD;Acc:S000005700]
O	YOR175C	ALE1	1033	-247.9	4	Broad-specificity lysophospholipid acyltransferase, part of MBOAT family of membrane-bound O-acyltransferases; key component of Lands cycle; may have role in fatty acid exchange at sn-2 position of mature glycerophospholipids [Source:SGD;Acc:S000005701]
O	YOR176W	HEM15	1350	-478.6	4	Ferrochelatase, a mitochondrial inner membrane protein, catalyzes the insertion of ferrous iron into protoporphyrin IX, the eighth and final step in the heme biosynthetic pathway [Source:SGD;Acc:S000005702]
O	YOR177C	MPC54	22	-53.9	4	Component of the meiotic outer plaque, a membrane-organizing center which is assembled on the cytoplasmic face of the spindle pole body during meiosis II and triggers the formation of the prospore membrane; potential Cdc28p substrate [Source:SGD;Acc:S000005703]
O	YOR178C	GAC1	153	-219.1	4	Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock [Source:SGD;Acc:S000005704]
O	YOR179C	SYC1	79	-62.7	4	Subunit of the APT subcomplex of cleavage and polyadenylation factor, may have a role in 3' end formation of both polyadenylated and non-polyadenylated RNAs [Source:SGD;Acc:S000005705]
O	YOR180C	DCI1	80	-77.9	4	Peroxisomal protein; identification as a delta(3,5)-delta(2,4)-dienoyl-CoA isomerase involved in fatty acid metabolism is disputed [Source:SGD;Acc:S000005706]
O	YOR181W	LAS17	492	-229.2	4	Actin assembly factor, activates the Arp2/3 protein complex that nucleates branched actin filaments; localizes with the Arp2/3 complex to actin patches; homolog of the human Wiskott-Aldrich syndrome protein (WASP) [Source:SGD;Acc:S000005707]
O	YOR182C	RPS30B	2425	-177.4	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps30Ap and has similarity to rat S30 ribosomal protein [Source:SGD;Acc:S000005708]
O	YOR183W	FYV12	5	-1.2	1	Protein of unknown function, required for survival upon exposure to K1 killer toxin [Source:SGD;Acc:S000005709]
O	YOR184W	SER1	2354	-818.1	4	3-phosphoserine aminotransferase, catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p [Source:SGD;Acc:S000005710]
O	YOR185C	GSP2	3542	-484.3	4	GTP binding protein (mammalian Ranp homolog) involved in the maintenance of nuclear organization, RNA processing and transport; interacts with Kap121p, Kap123p and Pdr6p (karyophilin betas); Gsp1p homolog that is not required for viability [Source:SGD;Acc:S000005711]
O	YOR186C-A	YOR186C-A	2	-1.1	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028715]
O	YOR186W	YOR186W	7	-24	2	Putative protein of unknown function; proper regulation of expression during heat stress is sphingolipid-dependent [Source:SGD;Acc:S000005712]
O	YOR187W	TUF1	2610	-793.2	4	Mitochondrial translation elongation factor Tu; comprises both GTPase and guanine nucleotide exchange factor activities, while these activities are found in separate proteins in S. pombe and humans [Source:SGD;Acc:S000005713]
O	YOR188W	MSB1	659	-272.5	4	Protein involved in positive regulation of both 1,3-beta-glucan synthesis and the Pkc1p-MAPK pathway, potential Cdc28p substrate; multicopy suppressor of temperature-sensitive mutations in CDC24 and CDC42, and of mutations in BEM4 [Source:SGD;Acc:S000005714]
O	YOR189W	IES4	318	-286.5	4	Component of the INO80 chromatiin remodeling complex and target of the Mec1p/Tel1p DNA damage signaling pathway; proposed to link chromatin remodeling to replication checkpoint responses [Source:SGD;Acc:S000005715]
O	YOR190W	SPR1	31	-23.9	4	Sporulation-specific exo-1,3-beta-glucanase; contributes to ascospore thermoresistance [Source:SGD;Acc:S000005716]
O	YOR191W	ULS1	338	-295.1	4	RING finger protein involved in proteolytic control of sumoylated substrates; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching [Source:SGD;Acc:S000005717]
O	YOR192C	THI72	158	-82.9	4	Transporter of thiamine or related compound; shares sequence similarity with Thi7p [Source:SGD;Acc:S000005718]
O	YOR192C-A	YOR192C-A	1079	-376.3	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007353]
O	YOR192C-B	YOR192C-B	2364	-751.1	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007354]
O	YOR192C-C	YOR192C-C	3	-1.2	1	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028857]
O	YOR193W	PEX27	78	-101.2	4	Peripheral peroxisomal membrane protein involved in controlling peroxisome size and number, interacts with homologous protein Pex25p [Source:SGD;Acc:S000005719]
O	YOR194C	TOA1	224	-106.9	4	TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA [Source:SGD;Acc:S000005720]
O	YOR195W	SLK19	808	-533.6	4	Kinetochore-associated protein required for normal segregation of chromosomes in meiosis and mitosis; component of the FEAR regulatory network, which promotes Cdc14p release from the nucleolus during anaphase; potential Cdc28p substrate [Source:SGD;Acc:S000005721]
O	YOR196C	LIP5	685	-307.8	4	Protein involved in biosynthesis of the coenzyme lipoic acid, has similarity to E. coli lipoic acid synthase [Source:SGD;Acc:S000005722]
O	YOR197W	MCA1	1494	-295.9	4	Putative cysteine protease similar to mammalian caspases; involved in regulation of apoptosis upon H2O2 treatment; contributes to clearance of insoluble protein aggregates during normal growth; may be involved in cell cycle progression [Source:SGD;Acc:S000005723]
O	YOR198C	BFR1	3208	-951.7	4	Component of mRNP complexes associated with polyribosomes; implicated in secretion and nuclear segregation; multicopy suppressor of BFA (Brefeldin A) sensitivity [Source:SGD;Acc:S000005724]
O	YOR199W	YOR199W	1	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005725]
O	YOR200W	YOR200W	10	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MRM1/YOR201c [Source:SGD;Acc:S000005726]
O	YOR201C	MRM1	242	-122.4	4	Ribose methyltransferase that modifies a functionally critical, conserved nucleotide in mitochondrial 21S rRNA [Source:SGD;Acc:S000005727]
O	YOR202W	HIS3	521	-94	4	Imidazoleglycerol-phosphate dehydratase, catalyzes the sixth step in histidine biosynthesis; mutations cause histidine auxotrophy and sensitivity to Cu, Co, and Ni salts; transcription is regulated by general amino acid control via Gcn4p [Source:SGD;Acc:S000005728]
O	YOR203W	YOR203W	2	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps 5' end of essential DED1 gene required for translation initiation [Source:SGD;Acc:S000005729]
O	YOR204W	DED1	4290	-846.3	4	ATP-dependent DEAD (Asp-Glu-Ala-Asp)-box RNA helicase, required for translation initiation of all yeast mRNAs; mutations in human DEAD-box DBY are a frequent cause of male infertility [Source:SGD;Acc:S000005730]
O	YOR205C	GEP3	139	-189.4	4	Protein of unknown function; null mutant is defective in respiration and interacts synthetically with prohibitin (phb1); the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005731]
O	YOR206W	NOC2	1945	-389.4	4	Protein that forms a nucleolar complex with Mak21p that binds to 90S and 66S pre-ribosomes, as well as a nuclear complex with Noc3p that binds to 66S pre-ribosomes; both complexes mediate intranuclear transport of ribosomal precursors [Source:SGD;Acc:S000005732]
O	YOR207C	RET1	1160	-686.5	4	Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs [Source:SGD;Acc:S000005733]
O	YOR208W	PTP2	211	-1494	4	Phosphotyrosine-specific protein phosphatase involved in the inactivation of mitogen-activated protein kinase (MAPK) during osmolarity sensing; dephosporylates Hog1p MAPK and regulates its localization; localized to the nucleus [Source:SGD;Acc:S000005734]
O	YOR209C	NPT1	1962	-597.1	4	Nicotinate phosphoribosyltransferase, acts in the salvage pathway of NAD+ biosynthesis; required for silencing at rDNA and telomeres and has a role in silencing at mating-type loci; localized to the nucleus [Source:SGD;Acc:S000005735]
O	YOR210W	RPB10	801	-101	4	RNA polymerase subunit ABC10-beta, common to RNA polymerases I, II, and III [Source:SGD;Acc:S000005736]
O	YOR211C	MGM1	779	-604.3	4	Mitochondrial GTPase, present in complex with Ugo1p and Fzo1p; required for mt morphology and genome maintenance; exists as long and short form with different distributions; homolog of human OPA1 involved in autosomal dominant optic atrophy [Source:SGD;Acc:S000005737]
O	YOR212W	STE4	634	-187.9	4	G protein beta subunit, forms a dimer with Ste18p to activate the mating signaling pathway, forms a heterotrimer with Gpa1p and Ste18p to dampen signaling; may recruit Rho1p to the polarized growth site during mating; contains WD40 repeats [Source:SGD;Acc:S000005738]
O	YOR213C	SAS5	70	-88.2	4	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity [Source:SGD;Acc:S000005739]
O	YOR214C	SPR2	5	-2.7	2	Putative protein of unknown function; YOR214C is not an essential gene [Source:SGD;Acc:S000005740]
O	YOR215C	AIM41	758	-295.5	4	Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss [Source:SGD;Acc:S000005741]
O	YOR216C	RUD3	578	-315.3	4	Golgi matrix protein involved in the structural organization of the cis-Golgi; interacts genetically with COG3 and USO1 [Source:SGD;Acc:S000005742]
O	YOR217W	RFC1	1264	-427.2	4	Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon [Source:SGD;Acc:S000005743]
O	YOR218C	YOR218C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene RFC1/YOR217W [Source:SGD;Acc:S000005744]
O	YOR219C	STE13	248	-384	4	Dipeptidyl aminopeptidase, Golgi integral membrane protein that cleaves on the carboxyl side of repeating -X-Ala- sequences, required for maturation of alpha factor, transcription is induced by a-factor [Source:SGD;Acc:S000005745]
O	YOR220W	RCN2	1282	-267.8	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; phosphorylated in response to alpha factor [Source:SGD;Acc:S000005746]
O	YOR221C	MCT1	414	-239	4	Predicted malonyl-CoA:ACP transferase, putative component of a type-II mitochondrial fatty acid synthase that produces intermediates for phospholipid remodeling [Source:SGD;Acc:S000005747]
O	YOR222W	ODC2	750	-198.8	4	Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism [Source:SGD;Acc:S000005748]
O	YOR223W	DSC3	124	-115.6	4	Protein of unknown function found in the ER and vacuole lumen; overexpression of YOR223W affects endocytic protein trafficking [Source:SGD;Acc:S000005749]
O	YOR224C	RPB8	1586	-178.9	4	RNA polymerase subunit ABC14.5, common to RNA polymerases I, II, and III [Source:SGD;Acc:S000005750]
O	YOR225W	YOR225W	7	-4.1	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005751]
O	YOR226C	ISU2	238	-71	4	Conserved protein of the mitochondrial matrix, required for synthesis of mitochondrial and cytosolic iron-sulfur proteins, performs a scaffolding function in mitochondria during Fe/S cluster assembly; isu1 isu2 double mutant is inviable [Source:SGD;Acc:S000005752]
O	YOR227W	HER1	755	-570	4	Protein of unknown function required for proliferation or remodeling of the ER that is caused by overexpression of Hmg2p; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000005753]
O	YOR228C	MCP1	62	-64	3	Protein of unknown function, localized to the mitochondrial outer membrane [Source:SGD;Acc:S000005754]
O	YOR229W	WTM2	576	-231.9	4	Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; involved in response to replication stress; contains WD repeats [Source:SGD;Acc:S000005755]
O	YOR230W	WTM1	2864	-782.8	4	Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats [Source:SGD;Acc:S000005756]
O	YOR231C-A	YOR231C-A	7	-3.2	2	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028716]
O	YOR231W	MKK1	153	-1582.4	4	Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p [Source:SGD;Acc:S000005757]
O	YOR232W	MGE1	1488	-242.8	4	Mitochondrial matrix cochaperone, acts as a nucleotide release factor for Ssc1p in protein translocation and folding; also acts as cochaperone for Ssq1p in folding of Fe-S cluster proteins; homolog of E. coli GrpE [Source:SGD;Acc:S000005758]
O	YOR233W	KIN4	535	-1390.2	4	Serine/threonine protein kinase that inhibits the mitotic exit network (MEN) when the spindle position checkpoint is activated; localized asymmetrically to mother cell cortex, spindle pole body and bud neck [Source:SGD;Acc:S000005759]
O	YOR234C	RPL33B	3183	-201.8	4	Ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Ap and has similarity to rat L35a; rpl33b null mutant exhibits normal growth while rpl33a rpl33b double null mutant is inviable [Source:SGD;Acc:S000005760]
O	YOR235W	IRC13	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays increased levels of spontaneous Rad52 foci [Source:SGD;Acc:S000005761]
O	YOR236W	DFR1	246	-113.3	4	Dihydrofolate reductase, part of the dTTP biosynthetic pathway, involved in folate metabolism, possibly required for mitochondrial function [Source:SGD;Acc:S000005762]
O	YOR237W	HES1	39	-92.5	4	Protein implicated in the regulation of ergosterol biosynthesis; one of a seven member gene family with a common essential function and non-essential unique functions; similar to human oxysterol binding protein (OSBP) [Source:SGD;Acc:S000005763]
O	YOR238W	YOR238W	296	-162.5	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000005764]
O	YOR239W	ABP140	1609	-684.9	4	AdoMet-dependent tRNA methyltransferase and actin binding protein; C-terminal domain is responsible for 3-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA-Thr and tRNA-Ser and contains an S-adenosylmethionine (AdoMet) bin  otif; N-terminal actin binding sequence interacts with actin filaments and localizes to actin patches and cables; N- and C-terminal domains are encoded in separate ORFs that are translated into one protein via a +1 frameshift [Source:SGD;Acc:S000005765]
O	YOR241W	MET7	754	-289.2	4	Folylpolyglutamate synthetase, catalyzes extension of the glutamate chains of the folate coenzymes, required for methionine synthesis and for maintenance of mitochondrial DNA [Source:SGD;Acc:S000005767]
O	YOR242C	SSP2	10	-2.3	2	Sporulation specific protein that localizes to the spore wall; required for sporulation at a point after meiosis II and during spore wall formation; SSP2 expression is induced midway in meiosis [Source:SGD;Acc:S000005768]
O	YOR243C	PUS7	1251	-498.8	4	Pseudouridine synthase, catalyzes pseudouridylation at positions 35 and 56 in U2 snRNA, position 50 in 5S rRNA, position 13 in cytoplasmic tRNAs, and position 35 in pre-tRNA(Tyr); conserved in archaea, vertebrates, and some bacteria [Source:SGD;Acc:S000005769]
O	YOR244W	ESA1	251	-346.5	4	Catalytic subunit of the histone acetyltransferase complex (NuA4) that acetylates four conserved internal lysines of histone H4 N-terminal tail; required for cell cycle progression and transcriptional silencing at the rDNA locus [Source:SGD;Acc:S000005770]
O	YOR245C	DGA1	193	-174	4	Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles [Source:SGD;Acc:S000005771]
O	YOR246C	ENV9	205	-88	4	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevi  a model system for studying replication of positive-strand RNA viruses in their natural hosts [Source:SGD;Acc:S000005772]
O	YOR247W	SRL1	5	-45.7	4	Mannoprotein that exhibits a tight association with the cell wall, required for cell wall stability in the absence of GPI-anchored mannoproteins; has a high serine-threonine content; expression is induced in cell wall mutants [Source:SGD;Acc:S000005773]
O	YOR248W	YOR248W	2	-3.4	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005774]
O	YOR249C	APC5	97	-287.4	4	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C), which is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain o  APC/C, based on structural analysis [Source:SGD;Acc:S000005775]
O	YOR250C	CLP1	334	-186.6	4	Component of the cleavage and polyadenylation factor I (CF I); CF 1, composed of the CF 1A complex (Rna14p, Rna15p, Clp1p, Pcf11p) and Hrp1, is involved in cleavage and polyadenylation of mRNA 3' ends; involved in both the endonucleolyitc cleavage a  yadenylation steps of mRNA 3'-end maturation [Source:SGD;Acc:S000005776]
O	YOR251C	TUM1	1459	-384.8	4	Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized [Source:SGD;Acc:S000005777]
O	YOR252W	TMA16	604	-108.2	4	Protein of unknown function that associates with ribosomes [Source:SGD;Acc:S000005778]
O	YOR253W	NAT5	874	-196.6	4	Subunit of the N-terminal acetyltransferase NatA (Nat1p, Ard1p, Nat5p); N-terminally acetylates many proteins, which influences multiple processes such as the cell cycle, heat-shock resistance, mating, sporulation, and telomeric silencing [Source:SGD;Acc:S000005779]
O	YOR254C	SEC63	1991	-584.8	4	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER [Source:SGD;Acc:S000005780]
O	YOR255W	OSW1	4	-5.1	2	Protein involved in sporulation; required for the construction of the outer spore wall layers; required for proper localization of Spo14p [Source:SGD;Acc:S000005781]
O	YOR256C	TRE2	167	-109.3	4	Protein that functions with Tre1p to regulate ubiquitylation and vacuolar degradation of the metal transporter Smf1p; has similarity to transferrin receptors; inviability of null mutant in systematic studies is due to proximity to CDC31 [Source:SGD;Acc:S000005782]
O	YOR257W	CDC31	587	-229	4	Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation [Source:SGD;Acc:S000005783]
O	YOR258W	HNT3	25	-34.5	4	DNA 5' AMP hydrolase involved in DNA repair; member of the histidine triad (HIT) superfamily of nucleotide-binding proteins; homolog of Aprataxin, a Hint related protein that is mutated in individuals with ataxia with oculomotor apraxia [Source:SGD;Acc:S000005784]
O	YOR259C	RPT4	2192	-595.4	4	One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in degradation of ubiquitinated substrates; contributes preferentially to ERAD; required for spindle pole body duplication; mainly nuclear localization [Source:SGD;Acc:S000005785]
O	YOR260W	GCD1	1253	-400.6	4	Gamma subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression [Source:SGD;Acc:S000005786]
O	YOR261C	RPN8	2257	-442.4	4	Essential, non-ATPase regulatory subunit of the 26S proteasome; has similarity to the human p40 proteasomal subunit and to another S. cerevisiae regulatory subunit, Rpn11p [Source:SGD;Acc:S000005787]
O	YOR262W	GPN2	320	-153.4	4	Protein of unknown function required for establishment of sister chromatid cohesion; contains an ATP/GTP binding site motif; similar to YLR243W and is highly conserved across species and homologous to human gene GPN2/ATPBD1B [Source:SGD;Acc:S000005788]
O	YOR263C	YOR263C	4	-3.8	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF DES3/YOR264W [Source:SGD;Acc:S000005789]
O	YOR264W	DSE3	105	-84.1	4	Daughter cell-specific protein, may help establish daughter fate [Source:SGD;Acc:S000005790]
O	YOR265W	RBL2	1412	-170.8	4	Protein involved in microtubule morphogenesis, required for protection from excess free beta-tubulin; proposed to be involved the folding of beta-tubulin; similar to mouse beta-tubulin cofactor A [Source:SGD;Acc:S000005791]
O	YOR266W	PNT1	174	-142.3	4	Mitochondrial integral inner membrane protein involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p; deletion mutant sensitive to the anti-Pneumocystis carinii drug pentamidine [Source:SGD;Acc:S000005792]
O	YOR267C	HRK1	1274	-592.7	4	Protein kinase implicated in activation of the plasma membrane H(+)-ATPase Pma1p in response to glucose metabolism; plays a role in ion homeostasis [Source:SGD;Acc:S000005793]
O	YOR268C	YOR268C	0	nf	1	Putative protein of unknown function; sporulation is abnormal in homozygous diploid; YOR268C is not an essential gene [Source:SGD;Acc:S000005794]
O	YOR269W	PAC1	97	-99	4	Protein involved in nuclear migration, part of the dynein/dynactin pathway; targets dynein to microtubule tips, which is necessary for sliding of microtubules along bud cortex; synthetic lethal with bni1; homolog of human LIS1 [Source:SGD;Acc:S000005795]
O	YOR270C	VPH1	2537	-877.1	4	Subunit a of vacuolar-ATPase V0 domain, one of two isoforms (Vph1p and Stv1p); Vph1p is located in V-ATPase complexes of the vacuole while Stv1p is located in V-ATPase complexes of the Golgi and endosomes [Source:SGD;Acc:S000005796]
O	YOR271C	FSF1	1215	-418.1	4	Putative protein, predicted to be an alpha-isopropylmalate carrier; belongs to the sideroblastic-associated protein family; non-tagged protein is detected in purified mitochondria; likely to play a role in iron homeostasis [Source:SGD;Acc:S000005797]
O	YOR272W	YTM1	1552	-342.8	4	Constituent of 66S pre-ribosomal particles, forms a complex with Nop7p and Erb1p that is required for maturation of the large ribosomal subunit; has seven C-terminal WD repeats [Source:SGD;Acc:S000005798]
O	YOR273C	TPO4	471	-157.9	4	Polyamine transport protein, recognizes spermine, putrescine, and spermidine; localizes to the plasma membrane; member of the major facilitator superfamily [Source:SGD;Acc:S000005799]
O	YOR274W	MOD5	204	-220.5	4	Delta 2-isopentenyl pyrophosphate:tRNA isopentenyl transferase, required for biosynthesis of the modified base isopentenyladenosine in mitochondrial and cytoplasmic tRNAs; gene is nuclear and encodes two isozymic forms [Source:SGD;Acc:S000005800]
O	YOR275C	RIM20	302	-305.2	4	Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation [Source:SGD;Acc:S000005801]
O	YOR276W	CAF20	1832	-266.7	4	Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E [Source:SGD;Acc:S000005802]
O	YOR277C	YOR277C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20 [Source:SGD;Acc:S000005803]
O	YOR278W	HEM4	532	-188.5	4	Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria [Source:SGD;Acc:S000005804]
O	YOR279C	RFM1	163	-49.1	4	DNA-binding protein required for vegetative repression of middle sporulation genes; specificity factor that directs the Hst1p histone deacetylase to some of the promoters regulated by Sum1p; involved in telomere maintenance [Source:SGD;Acc:S000005805]
O	YOR280C	FSH3	608	-165.2	4	Putative serine hydrolase; likely target of Cyc8p-Tup1p-Rfx1p transcriptional regulation; sequence is similar to S. cerevisiae Fsh1p and Fsh2p and the human candidate tumor suppressor OVCA2 [Source:SGD;Acc:S000005806]
O	YOR281C	PLP2	1029	-154.1	4	Essential protein that interacts with the CCT (chaperonin containing TCP-1) complex to stimulate actin folding; has similarity to phosducins; null mutant lethality is complemented by mouse phosducin-like protein MgcPhLP [Source:SGD;Acc:S000005807]
O	YOR282W	YOR282W	2	-1.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C [Source:SGD;Acc:S000005808]
O	YOR283W	YOR283W	1028	-205.3	4	Phosphatase with a broad substrate specificity and some similarity to GPM1/YKL152C, a phosphoglycerate mutase; YOR283W is not an essential gene [Source:SGD;Acc:S000005809]
O	YOR284W	HUA2	128	-114.8	4	Cytoplasmic protein of unknown function; computational analysis of large-scale protein-protein interaction data suggests a possible role in actin patch assembly [Source:SGD;Acc:S000005810]
O	YOR285W	RDL1	1957	-240	4	Protein of unknown function containing a rhodanese-like domain; localized to the mitochondrial outer membrane [Source:SGD;Acc:S000005811]
O	YOR286W	RDL2	875	-103.4	4	Protein with rhodanese activity; contains a rhodanese-like domain similar to Rdl1p, Uba4p, Tum1p, and Ych1p; overexpression causes a cell cycle delay; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000005812]
O	YOR287C	RRP36	358	-85.5	4	Component of 90S preribosomes; involved in early cleavages of the 35S pre-rRNA and in production of the 40S ribosomal subunit [Source:SGD;Acc:S000005813]
O	YOR288C	MPD1	620	-286.2	4	Member of the protein disulfide isomerase (PDI) family; interacts with and inhibits the chaperone activity of Cne1p; MPD1 overexpression in a pdi1 null mutant suppresses defects in Pdi1p functions such as carboxypeptidase Y maturation [Source:SGD;Acc:S000005814]
O	YOR289W	YOR289W	452	-181.4	4	Putative protein of unknown function; transcription induced by the unfolded protein response; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000005815]
O	YOR290C	SNF2	942	-584.1	4	Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p [Source:SGD;Acc:S000005816]
O	YOR291W	YPK9	485	-301.8	4	Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome [Source:SGD;Acc:S000005817]
O	YOR292C	YOR292C	3	-5	2	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene [Source:SGD;Acc:S000005818]
O	YOR293C-A	YOR293C-A	6	-3.6	2	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028858]
O	YOR293W	RPS10A	3000	-365.9	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps10Bp and has similarity to rat ribosomal protein S10 [Source:SGD;Acc:S000005819]
O	YOR294W	RRS1	1149	-193	4	Essential protein that binds ribosomal protein L11; required for nuclear export of the 60S pre-ribosomal subunit during ribosome biogenesis; localizes to the nucleolus and in foci along nuclear periphery; cooperates with Ebp2p and Mps3p to mediate t  e clustering by binding Sir4p, but is not involved in telomere tethering; mouse homolog shows altered expression in Huntington's disease model mice [Source:SGD;Acc:S000005820]
O	YOR295W	UAF30	89	-65	4	Subunit of UAF (upstream activation factor), which is an RNA polymerase I specific transcription stimulatory factor composed of Uaf30p, Rrn5p, Rrn9p, Rrn10p, histones H3 and H4; deletion decreases cellular growth rate [Source:SGD;Acc:S000005821]
O	YOR296W	YOR296W	148	-356	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; expressed during copper starvation; YOR296W is not an essential gene [Source:SGD;Acc:S000005822]
O	YOR297C	TIM18	81	-79.2	4	Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex [Source:SGD;Acc:S000005823]
O	YOR298C-A	MBF1	2555	-283.9	4	Transcriptional coactivator that bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations [Source:SGD;Acc:S000007253]
O	YOR298W	MUM3	33	-16.2	2	Protein of unknown function involved in the organization of the outer spore wall layers; has similarity to the tafazzins superfamily of acyltransferases [Source:SGD;Acc:S000005824]
O	YOR299W	BUD7	313	-326	4	Member of the ChAPs family of proteins (Chs5p-Arf1p-binding proteins: Bch1p, Bch2p, Bud7p, Chs6p), that forms the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane [Source:SGD;Acc:S000005825]
O	YOR300W	YOR300W	1	-2.5	2	Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7 [Source:SGD;Acc:S000005826]
O	YOR301W	RAX1	235	-136.1	4	Protein involved in bud site selection during bipolar budding; localization requires Rax2p; has similarity to members of the insulin-related peptide superfamily [Source:SGD;Acc:S000005827]
O	YOR302W	YOR302W	0	nf	1	CPA1 uORF, Arginine attenuator peptide, regulates translation of the CPA1 mRNA [Source:SGD;Acc:S000005828]
O	YOR303W	CPA1	1066	-514.4	4	Small subunit of carbamoyl phosphate synthetase, which catalyzes a step in the synthesis of citrulline, an arginine precursor; translationally regulated by an attenuator peptide encoded by YOR302W within the CPA1 mRNA 5'-leader [Source:SGD;Acc:S000005829]
O	YOR304C-A	BIL1	137	-45.5	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck [Source:SGD;Acc:S000005830]
O	YOR304W	ISW2	867	-395.9	4	ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth [Source:SGD;Acc:S000005831]
O	YOR305W	RRG7	51	-117.1	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO); YOR305W is not an essential gene [Source:SGD;Acc:S000005832]
O	YOR306C	MCH5	30	-7.7	4	Plasma membrane riboflavin transporter; facilitates the uptake of vitamin B2; required for FAD-dependent processes; sequence similarity to mammalian monocarboxylate permeases, however mutants are not deficient in monocarboxylate transport [Source:SGD;Acc:S000005833]
O	YOR307C	SLY41	220	-88.5	4	Protein involved in ER-to-Golgi transport [Source:SGD;Acc:S000005834]
O	YOR308C	SNU66	323	-227.1	4	Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1 [Source:SGD;Acc:S000005835]
O	YOR309C	YOR309C	18	-27.8	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58 [Source:SGD;Acc:S000005836]
O	YOR310C	NOP58	3788	-788.6	4	Protein involved in pre-rRNA processing, 18S rRNA synthesis, and snoRNA synthesis; component of the small subunit processome complex, which is required for processing of pre-18S rRNA [Source:SGD;Acc:S000005837]
O	YOR311C	DGK1	323	-80.6	4	Diacylglycerol kinase, localized to the endoplasmic reticulum (ER); overproduction induces enlargement of ER-like membrane structures and suppresses a temperature-sensitive sly1 mutation; contains a CTP transferase domain [Source:SGD;Acc:S000005838]
O	YOR312C	RPL20B	4112	-655.3	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl20Ap and has similarity to rat L18a ribosomal protein [Source:SGD;Acc:S000005839]
O	YOR313C	SPS4	9	-12.2	2	Protein whose expression is induced during sporulation; not required for sporulation; heterologous expression in E. coli induces the SOS response that senses DNA damage [Source:SGD;Acc:S000005840]
O	YOR314W	YOR314W	3	-1.6	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005841]
O	YOR314W-A	YOR314W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007629]
O	YOR315W	SFG1	27	-31.9	4	Nuclear protein, putative transcription factor required for growth of superficial pseudohyphae (which do not invade the agar substrate) but not for invasive pseudohyphal growth; may act together with Phd1p; potential Cdc28p substrate [Source:SGD;Acc:S000005842]
O	YOR316C	COT1	491	-156.6	4	Vacuolar transporter that mediates zinc transport into the vacuole; overexpression confers resistance to cobalt and rhodium [Source:SGD;Acc:S000005843]
O	YOR316C-A	YOR316C-A	9	-2.5	2	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028584]
O	YOR317W	FAA1	3013	-1034.1	4	Long chain fatty acyl-CoA synthetase, activates imported fatty acids with a preference for C12:0-C16:0 chain lengths; functions in long chain fatty acid import; accounts for most acyl-CoA synthetase activity; localized to lipid particles [Source:SGD;Acc:S000005844]
O	YOR318C	YOR318C	5	-1.5	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo [Source:SGD;Acc:S000005845]
O	YOR319W	HSH49	198	-154.5	4	U2-snRNP associated splicing factor with similarity to the mammalian splicing factor SAP49; proposed to function as a U2-snRNP assembly factor along with Hsh155p and binding partner Cus1p; contains two RNA recognition motifs (RRM) [Source:SGD;Acc:S000005846]
O	YOR320C	GNT1	438	-283.5	4	N-acetylglucosaminyltransferase capable of modification of N-linked glycans in the Golgi apparatus [Source:SGD;Acc:S000005847]
O	YOR321W	PMT3	561	-247.9	4	Protein O-mannosyltransferase, transfers mannose residues from dolichyl phosphate-D-mannose to protein serine/threonine residues; acts in a complex with Pmt5p, can instead interact with Pmt1p in some conditions; target for new antifungals [Source:SGD;Acc:S000005848]
O	YOR322C	LDB19	516	-319.7	4	Protein involved in regulating the endocytosis of plasma membrane proteins by recruiting the ubiquitin ligase Rsp5p to its target; localization changes in response to nutrient levels; null mutant has reduced affinity for alcian blue dye [Source:SGD;Acc:S000005849]
O	YOR323C	PRO2	2346	-501.5	4	Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis [Source:SGD;Acc:S000005850]
O	YOR324C	FRT1	120	-133.6	4	Tail-anchored ER membrane protein that is a substrate of the phosphatase calcineurin; interacts with homolog Frt2p; promotes cell growth in stress conditions, possibly via a role in posttranslational translocation [Source:SGD;Acc:S000005851]
O	YOR325W	YOR325W	2	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1 [Source:SGD;Acc:S000005852]
O	YOR326W	MYO2	2339	-1576.8	4	One of two type V myosin motors (along with MYO4) involved in actin-based transport of cargos; required for the polarized delivery of secretory vesicles, the vacuole, late Golgi elements, peroxisomes, and the mitotic spindle [Source:SGD;Acc:S000005853]
O	YOR327C	SNC2	759	-128.3	4	Vesicle membrane receptor protein (v-SNARE) involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins [Source:SGD;Acc:S000005854]
O	YOR328W	PDR10	1218	-290.2	4	ATP-binding cassette (ABC) transporter, multidrug transporter involved in the pleiotropic drug resistance network; regulated by Pdr1p and Pdr3p [Source:SGD;Acc:S000005855]
O	YOR329C	SCD5	466	-229.1	4	Protein required for normal actin organization and endocytosis; targeting subunit for protein phosphatase type 1; undergoes Crm1p-dependent nuclear-cytoplasmic shuttling; multicopy suppressor of clathrin deficiency [Source:SGD;Acc:S000005856]
O	YOR329W-A	YOR329W-A	4	-8.7	2	Dubious open reading frame unlikely to encode a functional protein; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028585]
O	YOR330C	MIP1	244	-183.2	4	Catalytic subunit of the mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; related to human POLG, which has been associated with mitochondrial diseases [Source:SGD;Acc:S000005857]
O	YOR331C	YOR331C	6	-2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene VMA4/YOR332W [Source:SGD;Acc:S000005858]
O	YOR332W	VMA4	2920	-404.1	4	Subunit E of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane [Source:SGD;Acc:S000005859]
O	YOR333C	YOR333C	5	-3.1	2	Dubious open reading frame, unlikely to encode a functional protein; overlaps 5' end of MRS2 gene required for respiratory growth [Source:SGD;Acc:S000005860]
O	YOR334W	MRS2	31	-58.1	4	Mitochondrial inner membrane Mg(2+) channel, required for maintenance of intramitochondrial Mg(2+) concentrations at the correct level to support splicing of group II introns [Source:SGD;Acc:S000005861]
O	YOR335C	ALA1	3371	-1463.1	4	Cytoplasmic and mitochondrial alanyl-tRNA synthetase, required for protein synthesis; point mutation (cdc64-1 allele) causes cell cycle arrest at G1; lethality of null mutation is functionally complemented by human homolog [Source:SGD;Acc:S000005862]
O	YOR335W-A	YOR335W-A	1	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene ALA1/YOR335C [Source:SGD;Acc:S000028717]
O	YOR336W	KRE5	641	-644.4	4	Protein required for beta-1,6 glucan biosynthesis; mutations result in aberrant morphology and severe growth defects [Source:SGD;Acc:S000005863]
O	YOR337W	TEA1	145	-105	4	Ty1 enhancer activator required for full levels of Ty enhancer-mediated transcription; C6 zinc cluster DNA-binding protein [Source:SGD;Acc:S000005864]
O	YOR338W	YOR338W	66	-40.3	4	Putative protein of unknown function; YOR338W transcription is regulated by Azf1p and its transcript is a specific target of the G protein effector Scp160p; identified as being required for sporulation in a high-throughput mutant screen [Source:SGD;Acc:S000005865]
O	YOR339C	UBC11	13	-4.8	2	Ubiquitin-conjugating enzyme most similar in sequence to Xenopus ubiquitin-conjugating enzyme E2-C, but not a true functional homolog of this E2; unlike E2-C, not required for the degradation of mitotic cyclin Clb2 [Source:SGD;Acc:S000005866]
O	YOR340C	RPA43	1365	-223.5	4	RNA polymerase I subunit A43 [Source:SGD;Acc:S000005867]
O	YOR341W	RPA190	3083	-1536.4	4	RNA polymerase I largest subunit A190 [Source:SGD;Acc:S000005868]
O	YOR342C	YOR342C	19	-17.9	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus [Source:SGD;Acc:S000005869]
O	YOR343C	YOR343C	7	-15.2	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005870]
O	YOR343W-A	YOR343W-A	1046	-363.4	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007355]
O	YOR343W-B	YOR343W-B	2358	-703.8	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007356]
O	YOR344C	TYE7	118	-106.2	4	Serine-rich protein that contains a basic-helix-loop-helix (bHLH) DNA binding motif; binds E-boxes of glycolytic genes and contributes to their activation; may function as a transcriptional activator in Ty1-mediated gene expression [Source:SGD;Acc:S000005871]
O	YOR345C	YOR345C	2	-2.3	2	Dubious ORF unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps the verified gene REV1; null mutant displays increased resistance to antifungal agents gliotoxin, cycloheximide and H2O2 [Source:SGD;Acc:S000005872]
O	YOR346W	REV1	58	-43.7	4	Deoxycytidyl transferase; involved in repair of abasic sites and adducted guanines in damaged DNA by translesion synthesis (TLS); forms a complex with the subunits of DNA polymerase zeta, Rev3p and Rev7p; [Source:SGD;Acc:S000005873]
O	YOR347C	PYK2	3478	-494	4	Pyruvate kinase that appears to be modulated by phosphorylation; PYK2 transcription is repressed by glucose, and Pyk2p may be active under low glycolytic flux [Source:SGD;Acc:S000005874]
O	YOR348C	PUT4	64	-91	4	Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells [Source:SGD;Acc:S000005875]
O	YOR349W	CIN1	85	-225.4	4	Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl [Source:SGD;Acc:S000005876]
O	YOR350C	MNE1	65	-144.3	4	Mitochondrial matrix protein involved in splicing Group I aI5-beta intron from COX1 mRNA [Source:SGD;Acc:S000005877]
O	YOR351C	MEK1	15	-630.5	4	Meiosis-specific serine/threonine protein kinase, functions in meiotic checkpoint, promotes recombination between homologous chromosomes by suppressing double strand break repair between sister chromatids [Source:SGD;Acc:S000005878]
O	YOR352W	TFB6	496	-281.9	4	Putative protein of unknown function; expression levels regulated by Arg5,6p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus [Source:SGD;Acc:S000005879]
O	YOR353C	SOG2	305	-679.9	4	Key component of the RAM signaling network, required for proper cell morphogenesis and cell separation after mitosis [Source:SGD;Acc:S000005880]
O	YOR354C	MSC6	732	-694.1	4	Protein of unknown function; mutant is defective in directing meiotic recombination events to homologous chromatids; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005881]
O	YOR355W	GDS1	209	-118.2	4	Protein of unknown function, required for growth on glycerol as a carbon source; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005882]
O	YOR356W	CIR2	1185	-386.9	4	Putative ortholog of human electron transfer flavoprotein dehydrogenase (ETF-dH); found in a large supramolecular complex with other mitochondrial dehydrogenases; may have a role in oxidative stress response [Source:SGD;Acc:S000005883]
O	YOR357C	SNX3	508	-107.1	4	Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p [Source:SGD;Acc:S000005884]
O	YOR358W	HAP5	199	-123.8	4	Subunit of the heme-activated, glucose-repressed Hap2/3/4/5 CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; required for assembly and DNA binding activity of the complex [Source:SGD;Acc:S000005885]
O	YOR359W	VTS1	552	-116.2	4	Post-transcriptional gene regulator, flap-structured DNA-binding and RNA-binding protein; shows genetic interactions with Vti1p, a v-SNARE involved in cis-Golgi membrane traffic; stimulates Dna2p endonuclease activity; contains a SAM domain [Source:SGD;Acc:S000005886]
O	YOR360C	PDE2	459	-145.1	4	High-affinity cyclic AMP phosphodiesterase, component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon [Source:SGD;Acc:S000005887]
O	YOR361C	PRT1	2854	-1014.9	4	eIF3b subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a subcomplex (Prt1p-Rpg1p-Nip1p) that stimulates binding of mRNA and tRNA(i)Met to ribosomes [Source:SGD;Acc:S000005888]
O	YOR362C	PRE10	2092	-315.4	4	Alpha 7 subunit of the 20S proteasome [Source:SGD;Acc:S000005889]
O	YOR363C	PIP2	95	-75.5	4	Autoregulatory oleate-specific transcriptional activator of peroxisome proliferation, contains Zn(2)-Cys(6) cluster domain, forms heterodimer with Oaf1p, binds oleate response elements (OREs), activates beta-oxidation genes [Source:SGD;Acc:S000005890]
O	YOR364W	YOR364W	1	-2.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C [Source:SGD;Acc:S000005891]
O	YOR365C	YOR365C	37	-12.6	2	Putative protein of unknown function; YOR365C is not an essential protein [Source:SGD;Acc:S000005892]
O	YOR366W	YOR366W	15	-12.8	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR365C [Source:SGD;Acc:S000005893]
O	YOR367W	SCP1	579	-118.5	4	Component of yeast cortical actin cytoskeleton, binds and cross links actin filaments; originally identified by its homology to calponin (contains a calponin-like repeat) but the Scp1p domain structure is more similar to transgelin [Source:SGD;Acc:S000005894]
O	YOR368W	RAD17	54	-77.8	4	Checkpoint protein, involved in the activation of the DNA damage and meiotic pachytene checkpoints; with Mec3p and Ddc1p, forms a clamp that is loaded onto partial duplex DNA; homolog of human and S. pombe Rad1 and U. maydis Rec1 proteins [Source:SGD;Acc:S000005895]
O	YOR369C	RPS12	4402	-444.4	4	Protein component of the small (40S) ribosomal subunit; has similarity to rat ribosomal protein S12 [Source:SGD;Acc:S000005896]
O	YOR370C	MRS6	703	-390.4	4	Rab escort protein, forms a complex with the Ras-like small GTPase Ypt1p that is required for the prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p); sequence similarity to mammalian choroideraemia gene [Source:SGD;Acc:S000005897]
O	YOR371C	GPB1	459	-234.3	4	Multistep regulator of cAMP-PKA signaling; inhibits PKA downstream of Gpa2p and Cyr1p, thereby increasing cAMP dependency; promotes ubiquitin-dependent proteolysis of Ira2p; regulated by G-alpha protein Gpa2p; homolog of Gpb2p [Source:SGD;Acc:S000005898]
O	YOR372C	NDD1	146	-82.4	4	Transcriptional activator essential for nuclear division; localized to the nucleus; essential component of the mechanism that activates the expression of a set of late-S-phase-specific genes [Source:SGD;Acc:S000005899]
O	YOR373W	NUD1	558	-205.3	4	Component of the spindle pole body outer plaque, required for exit from mitosis [Source:SGD;Acc:S000005900]
O	YOR374W	ALD4	3265	-1493.4	4	Mitochondrial aldehyde dehydrogenase, required for growth on ethanol and conversion of acetaldehyde to acetate; phosphorylated; activity is K+ dependent; utilizes NADP+ or NAD+ equally as coenzymes; expression is glucose repressed [Source:SGD;Acc:S000005901]
O	YOR375C	GDH1	3617	-1649	4	NADP(+)-dependent glutamate dehydrogenase, synthesizes glutamate from ammonia and alpha-ketoglutarate; rate of alpha-ketoglutarate utilization differs from Gdh3p; expression regulated by nitrogen and carbon sources [Source:SGD;Acc:S000005902]
O	YOR376W	YOR376W	9	-3.6	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YOR376W is not an essential gene. [Source:SGD;Acc:S000005903]
O	YOR376W-A	YOR376W-A	0	nf	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028586]
O	YOR377W	ATF1	169	-82.1	4	Alcohol acetyltransferase with potential roles in lipid and sterol metabolism; responsible for the major part of volatile acetate ester production during fermentation [Source:SGD;Acc:S000005904]
O	YOR378W	AMF1	13	-10.7	2	Putative paralog of ATR1, but not required for boron tolerance; member of the DHA2 family of drug:H+ antiporters; YOR378W is not an essential gene [Source:SGD;Acc:S000005905]
O	YOR379C	YOR379C	3	-3.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YOR378W [Source:SGD;Acc:S000005906]
O	YOR380W	RDR1	37	-22.6	3	Transcriptional repressor involved in the control of multidrug resistance; negatively regulates expression of the PDR5 gene; member of the Gal4p family of zinc cluster proteins [Source:SGD;Acc:S000005907]
O	YOR381W	FRE3	12	-27.5	3	Ferric reductase, reduces siderophore-bound iron prior to uptake by transporters; expression induced by low iron levels [Source:SGD;Acc:S000005908]
O	YOR381W-A	YOR381W-A	23	-5.1	2	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028587]
O	YOR382W	FIT2	32	-43.6	4	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall [Source:SGD;Acc:S000005909]
O	YOR383C	FIT3	3	-2.6	2	Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall [Source:SGD;Acc:S000005910]
O	YOR384W	FRE5	27	-160.8	3	Putative ferric reductase with similarity to Fre2p; expression induced by low iron levels; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000005911]
O	YOR385W	YOR385W	176	-133.2	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YOR385W is not an essential gene [Source:SGD;Acc:S000005912]
O	YOR386W	PHR1	126	-235.6	4	DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p [Source:SGD;Acc:S000005913]
O	YOR387C	YOR387C	6	-90.1	4	Putative protein of unknown function; regulated by the metal-responsive Aft1p transcription factor; highly inducible in zinc-depleted conditions; localizes to the soluble fraction [Source:SGD;Acc:S000005914]
O	YOR388C	FDH1	131	-400.6	4	NAD(+)-dependent formate dehydrogenase, may protect cells from exogenous formate [Source:SGD;Acc:S000005915]
O	YOR389W	YOR389W	51	-150.5	4	Putative protein of unknown function; expression regulated by copper levels [Source:SGD;Acc:S000005916]
O	YOR390W	FEX1	53	-74.5	3	Putative protein of unknown function [Source:SGD;Acc:S000005917]
O	YOR391C	HSP33	126	-154.1	4	Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp32p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease [Source:SGD;Acc:S000005918]
O	YOR392W	YOR392W	1	-4.7	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; gene expression induced by heat [Source:SGD;Acc:S000005919]
O	YOR393W	ERR1	397	-415	4	Protein of unknown function, has similarity to enolases [Source:SGD;Acc:S000005920]
O	YOR394C-A	YOR394C-A	0	nf	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028718]
O	YOR394W	PAU21	17	-2.3	2	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau22p; encodes 2 proteins that are translated from 2 different start codons [Source:SGD;Acc:S000005921]
O	YOR396C-A	YOR396C-A	1	-1.8	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028719]
O	YOR396W	YRF1-8	416	-490.2	4	One of several telomeric Y' element-encoded DNA helicases, known as Y'-Help1 (Y'-HELicase Protein 1) [Source:SGD;Acc:S000007526]
P	YPL001W	HAT1	438	-1083.1	4	Catalytic subunit of the Hat1p-Hat2p histone acetyltransferase complex that uses the cofactor acetyl coenzyme A, to acetylate free nuclear and cytoplasmic histone H4; involved in telomeric silencing and DNA double-strand break repair [Source:SGD;Acc:S000005922]
P	YPL002C	SNF8	69	-98.5	4	Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression [Source:SGD;Acc:S000005923]
P	YPL003W	ULA1	94	-93.2	4	Protein that acts together with Uba3p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation [Source:SGD;Acc:S000005924]
P	YPL004C	LSP1	3626	-1050.8	4	Primary component of eisosomes, which are large immobile patch structures at the cell cortex associated with endocytosis, along with Pil1p and Sur7p; null mutants show activation of Pkc1p/Ypk1p stress resistance pathways; member of the BAR domain family [Source:SGD;Acc:S000005925]
P	YPL005W	AEP3	54	-127.5	4	Protein that may facilitate use of unformylated tRNA-Met in mitochondrial translation initiation; localized to the matrix face of the mitochondrial inner membrane; stabilizes the bicistronic AAP1-ATP6 mRNA [Source:SGD;Acc:S000005926]
P	YPL006W	NCR1	393	-447.1	4	Vacuolar membrane protein that transits through the biosynthetic vacuolar protein sorting pathway, involved in sphingolipid metabolism; glycoprotein and functional orthologue of human Niemann Pick C1 (NPC1) protein [Source:SGD;Acc:S000005927]
P	YPL007C	TFC8	150	-120.4	4	One of six subunits of RNA polymerase III transcription initiation factor complex (TFIIIC); part of TFIIIC TauB domain that binds BoxB promoter sites of tRNA and other genes; linker between TauB and TauA domains; human homolog is TFIIIC-90 [Source:SGD;Acc:S000005928]
P	YPL008W	CHL1	151	-228.9	4	Probable DNA helicase involved in sister-chromatid cohesion and genome integrity; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member [Source:SGD;Acc:S000005929]
P	YPL009C	TAE2	1599	-437.9	4	Protein of unknown function, involved in protein translation; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000005930]
P	YPL010W	RET3	1006	-164.5	4	Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER [Source:SGD;Acc:S000005931]
P	YPL011C	TAF3	420	-855.2	4	TFIID subunit (47 kDa), involved in promoter binding and RNA polymerase II transcription initiation [Source:SGD;Acc:S000005932]
P	YPL012W	RRP12	2125	-819.4	4	Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats [Source:SGD;Acc:S000005933]
P	YPL013C	MRPS16	438	-149.9	4	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000005934]
P	YPL014W	YPL014W	134	-67.6	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and to the nucleus [Source:SGD;Acc:S000005935]
P	YPL015C	HST2	467	-111.6	4	Cytoplasmic member of the silencing information regulator 2 (Sir2) family of NAD(+)-dependent protein deacetylases; modulates nucleolar (rDNA) and telomeric silencing; possesses NAD(+)-dependent histone deacetylase activity in vitro [Source:SGD;Acc:S000005936]
P	YPL016W	SWI1	649	-409.3	4	Subunit of the SWI/SNF chromatin remodeling complex, which regulates transcription by remodeling chromosomes; required for transcription of many genes, including ADH1, ADH2, GAL1, HO, INO1 and SUC2; can form the prion [SWI+]; human homolog ARID1A is  didate tumor suppressor gene in breast cancer [Source:SGD;Acc:S000005937]
P	YPL017C	IRC15	123	-141.6	4	Microtubule associated protein; regulates microtubule dynamics; required for accurate meiotic chromosome segregation; null mutant displays large budded cells due to delayed mitotic progression, increased levels of spontaneous Rad52 foci [Source:SGD;Acc:S000005938]
P	YPL018W	CTF19	59	-42.3	4	Outer kinetochore protein, required for accurate mitotic chromosome segregation; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p) that functions as a platform for kinetochore assembly [Source:SGD;Acc:S000005939]
P	YPL019C	VTC3	2159	-593.7	4	Subunit of the vacuolar transporter chaperone (VTC) complex involved in membrane trafficking, vacuolar polyphosphate accumulation, microautophagy and non-autophagic vacuolar fusion [Source:SGD;Acc:S000005940]
P	YPL020C	ULP1	491	-312.8	4	Protease that specifically cleaves Smt3p protein conjugates; required for cell cycle progression; associates with nucleoporins and may interact with septin rings during telophase; sequestered to the nucleolus under stress conditions [Source:SGD;Acc:S000005941]
P	YPL021W	ECM23	7	-2.2	2	Non-essential protein of unconfirmed function; affects pre-rRNA processing, may act as a negative regulator of the transcription of genes involved in pseudohyphal growth; homologous to Srd1p [Source:SGD;Acc:S000005942]
P	YPL022W	RAD1	272	-303.3	4	Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein [Source:SGD;Acc:S000005943]
P	YPL023C	MET12	640	-366.4	4	Protein with methylenetetrahydrofolate reductase (MTHFR) activity in vitro; null mutant has no phenotype and is prototrophic for methionine; MET13 encodes major isozyme of MTHFR [Source:SGD;Acc:S000005944]
P	YPL024W	RMI1	26	-17.7	3	Subunit of the RecQ (Sgs1p) - Topo III (Top3p) complex; stimulates superhelical relaxing and ssDNA binding activities of Top3p; involved in response to DNA damage; null mutants display increased rates of recombination and delayed S phase [Source:SGD;Acc:S000005945]
P	YPL025C	YPL025C	5	-2.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000005946]
P	YPL026C	SKS1	126	-962.2	4	Putative serine/threonine protein kinase; involved in the adaptation to low concentrations of glucose independent of the SNF3 regulated pathway [Source:SGD;Acc:S000005947]
P	YPL027W	SMA1	5	-3.4	2	Protein of unknown function involved in the assembly of the prospore membrane during sporulation; interacts with Spo14p [Source:SGD;Acc:S000005948]
P	YPL028W	ERG10	3066	-913.9	4	Acetyl-CoA C-acetyltransferase (acetoacetyl-CoA thiolase), cytosolic enzyme that transfers an acetyl group from one acetyl-CoA molecule to another, forming acetoacetyl-CoA; involved in the first step in mevalonate biosynthesis [Source:SGD;Acc:S000005949]
P	YPL029W	SUV3	118	-140.1	4	ATP-dependent RNA helicase, component of the mitochondrial degradosome along with the RNase Dss1p; the degradosome associates with the ribosome and mediates RNA turnover; also required during splicing of the COX1 AI5_beta intron [Source:SGD;Acc:S000005950]
P	YPL030W	TRM44	588	-273.9	4	tRNA(Ser) Um(44) 2'-O-methyltransferase; involved in maintaining levels of the tRNA-Ser species tS(CGA) and tS(UGA); conserved among metazoans and fungi but there does not appear to be a homolog in plants; TRM44 is a non-essential gene [Source:SGD;Acc:S000005951]
P	YPL031C	PHO85	1001	-407.9	4	Cyclin-dependent kinase, with ten cyclin partners; involved in regulating the cellular response to nutrient levels and environmental conditions and progression through the cell cycle [Source:SGD;Acc:S000005952]
P	YPL032C	SVL3	1512	-535.2	4	Protein of unknown function, mutant phenotype suggests a potential role in vacuolar function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck [Source:SGD;Acc:S000005953]
P	YPL033C	SRL4	4	-2.6	2	Protein of unknown function; involved in regulation of dNTP production; null mutant suppresses the lethality of lcd1 and rad53 mutations; expression is induced by Kar4p [Source:SGD;Acc:S000005954]
P	YPL034W	YPL034W	28	-28.5	4	Putative protein of unknown function; YPL034W is not essential gene [Source:SGD;Acc:S000005955]
P	YPL035C	YPL035C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized gene YPL034W; YPL035C is not an essential gene [Source:SGD;Acc:S000005956]
P	YPL036W	PMA2	5007	-1398.6	4	Plasma membrane H+-ATPase, isoform of Pma1p, involved in pumping protons out of the cell; regulator of cytoplasmic pH and plasma membrane potential [Source:SGD;Acc:S000005957]
P	YPL037C	EGD1	2357	-443.4	4	Subunit beta1 of the nascent polypeptide-associated complex (NAC) involved in protein targeting, associated with cytoplasmic ribosomes; enhances DNA binding of the Gal4p activator; homolog of human BTF3b [Source:SGD;Acc:S000005958]
P	YPL038W	MET31	112	-58.8	4	Zinc-finger DNA-binding protein, involved in transcriptional regulation of the methionine biosynthetic genes, similar to Met32p [Source:SGD;Acc:S000005959]
P	YPL038W-A	YPL038W-A	1	-1.6	1	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028588]
P	YPL039W	YPL039W	33	-7.8	2	Putative protein of unknown function; YPL039W is not an essential gene [Source:SGD;Acc:S000005960]
P	YPL040C	ISM1	299	-393.1	4	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth [Source:SGD;Acc:S000005961]
P	YPL041C	YPL041C	18	-19.8	2	Protein of unknown function involved in maintenance of proper telomere length [Source:SGD;Acc:S000005962]
P	YPL042C	SSN3	154	-1834.6	4	Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression [Source:SGD;Acc:S000005963]
P	YPL043W	NOP4	1394	-349.4	4	Nucleolar protein, essential for processing and maturation of 27S pre-rRNA and large ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; contains four RNA recognition motifs (RRMs) [Source:SGD;Acc:S000005964]
P	YPL044C	YPL044C	3	-6	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP4/YPL043W [Source:SGD;Acc:S000005965]
P	YPL045W	VPS16	256	-290.9	4	Subunit of the vacuole fusion and protein sorting HOPS complex and the CORVET tethering complex; part of the Class C Vps complex essential for membrane docking and fusion at Golgi-to-endosome and endosome-to-vacuole protein transport stages [Source:SGD;Acc:S000005966]
P	YPL046C	ELC1	145	-58.9	4	Elongin C, conserved among eukaryotes; forms a complex with Cul3p that polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair [Source:SGD;Acc:S000005967]
P	YPL047W	SGF11	222	-220.4	4	Integral subunit of SAGA histone acetyltransferase complex, regulates transcription of a subset of SAGA-regulated genes, required for the Ubp8p association with SAGA and for H2B deubiquitylation [Source:SGD;Acc:S000005968]
P	YPL048W	CAM1	3308	-735.3	4	Nuclear protein required for transcription of MXR1; binds the MXR1 promoter in the presence of other nuclear factors; binds calcium and phospholipids; has similarity to translational cofactor EF-1 gamma [Source:SGD;Acc:S000005969]
P	YPL049C	DIG1	1296	-800.7	4	MAP kinase-responsive inhibitor of the Ste12p transcription factor, involved in the regulation of mating-specific genes and the invasive growth pathway; related regulators Dig1p and Dig2p bind to Ste12p [Source:SGD;Acc:S000005970]
P	YPL050C	MNN9	1111	-301.5	4	Subunit of Golgi mannosyltransferase complex also containing Anp1p, Mnn10p, Mnn11p, and Hoc1p that mediates elongation of the polysaccharide mannan backbone; forms a separate complex with Van1p that is also involved in backbone elongation [Source:SGD;Acc:S000005971]
P	YPL051W	ARL3	238	-77.5	4	GTPase of the Ras superfamily required to recruit Arl1p to the Golgi; similar to ADP-ribosylation factor [Source:SGD;Acc:S000005972]
P	YPL052W	OAZ1	38	-45.8	3	Regulator of ornithine decarboxylase (Spe1p), antizyme that binds to Spe1p to stimulate ubiquitin-independent degradation by the proteasome; binding of polyamines to nascent Oaz1p during translation stimulates +1 ribosomal frameshifting, allowing tr  ion of full-length Oaz1p [Source:SGD;Acc:S000005973]
P	YPL053C	KTR6	384	-180.8	4	Probable mannosylphosphate transferase involved in the synthesis of core oligosaccharides in protein glycosylation pathway; member of the KRE2/MNT1 mannosyltransferase family [Source:SGD;Acc:S000005974]
P	YPL054W	LEE1	90	-115.4	4	Zinc-finger protein of unknown function [Source:SGD;Acc:S000005975]
P	YPL055C	LGE1	381	-131.7	4	Protein of unknown function; null mutant forms abnormally large cells, and homozygous diploid null mutant displays delayed premeiotic DNA synthesis and reduced efficiency of meiotic nuclear division [Source:SGD;Acc:S000005976]
P	YPL056C	LCL1	0	nf	1	Putative protein of unknown function; deletion mutant is fluconazole resistant and has long chronological lifespan [Source:SGD;Acc:S000005977]
P	YPL057C	SUR1	263	-93	4	Probable catalytic subunit of a mannosylinositol phosphorylceramide (MIPC) synthase, forms a complex with probable regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p [Source:SGD;Acc:S000005978]
P	YPL058C	PDR12	1047	-892.7	4	Plasma membrane ATP-binding cassette (ABC) transporter, weak-acid-inducible multidrug transporter required for weak organic acid resistance; induced by sorbate and benzoate and regulated by War1p; mutants exhibit sorbate hypersensitivity [Source:SGD;Acc:S000005979]
P	YPL059W	GRX5	1299	-273	4	Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; mitochondrial matrix protein involved in the synthesis/assembly of iron-sulfur centers; monothiol glutaredoxin subfamily member along with Grx3p and Grx4p [Source:SGD;Acc:S000005980]
P	YPL060W	MFM1	35	-99.4	4	Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p [Source:SGD;Acc:S000005981]
P	YPL061W	ALD6	4581	-1745.3	4	Cytosolic aldehyde dehydrogenase, activated by Mg2+ and utilizes NADP+ as the preferred coenzyme; required for conversion of acetaldehyde to acetate; constitutively expressed; locates to the mitochondrial outer surface upon oxidative stress [Source:SGD;Acc:S000005982]
P	YPL062W	YPL062W	8	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPL062W is not an essential gene; homozygous diploid mutant shows a decrease in glycogen accumulation [Source:SGD;Acc:S000005983]
P	YPL063W	TIM50	1616	-414.2	4	Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); acts as receptor for the TIM23 complex guiding incoming precursors from the TOM complex; may control the gating of the Tim23p-Tim17p channel [Source:SGD;Acc:S000005984]
P	YPL064C	CWC27	216	-107.5	4	Component of a complex containing Cef1p, putatively involved in pre-mRNA splicing; has similarity to S. pombe Cwf27p [Source:SGD;Acc:S000005985]
P	YPL065W	VPS28	254	-124.6	4	Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p [Source:SGD;Acc:S000005986]
P	YPL066W	RGL1	38	-45.3	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source [Source:SGD;Acc:S000005987]
P	YPL067C	YPL067C	460	-171.2	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL067C is not an essential gene [Source:SGD;Acc:S000005988]
P	YPL068C	YPL068C	45	-21.6	2	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000005989]
P	YPL069C	BTS1	221	-117.5	4	Geranylgeranyl diphosphate synthase, increases the intracellular pool of geranylgeranyl diphosphate, suppressor of bet2 mutation that causes defective geranylgeranylation of small GTP-binding proteins that mediate vesicular traffic [Source:SGD;Acc:S000005990]
P	YPL070W	MUK1	625	-282.2	4	Cytoplasmic protein of unknown function containing a Vps9 domain; computational analysis of large-scale protein-protein interaction data suggests a possible role in transcriptional regulation [Source:SGD;Acc:S000005991]
P	YPL071C	YPL071C	164	-52.8	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000005992]
P	YPL072W	UBP16	83	-152.8	4	Deubiquitinating enzyme anchored to the outer mitochondrial membrane, probably not important for general mitochondrial functioning, but may perform a more specialized function at mitochondria [Source:SGD;Acc:S000005993]
P	YPL073C	YPL073C	4	-4.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps with verified gene UBP16/YPL072W; may interact with ribosome based on co-purification experiments [Source:SGD;Acc:S000005994]
P	YPL074W	YTA6	386	-276.4	4	Putative ATPase of the CDC48/PAS1/SEC18 (AAA) family, localized to the cortex of mother cells but not to daughter cells [Source:SGD;Acc:S000005995]
P	YPL075W	GCR1	210	-276.6	4	Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p [Source:SGD;Acc:S000005996]
P	YPL076W	GPI2	15	-26.8	4	Protein involved in the synthesis of N-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the first intermediate in the synthesis of glycosylphosphatidylinositol (GPI) anchors; homologous to the human PIG-C protein [Source:SGD;Acc:S000005997]
P	YPL077C	YPL077C	197	-38.2	4	Putative protein of unknown function; regulates PIS1 expression; mutant displays spore wall assembly defect in ether sensitivity screen; YPL077C is not an essential gene [Source:SGD;Acc:S000005998]
P	YPL078C	ATP4	1785	-434.9	4	Subunit b of the stator stalk of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; contributes to the oligomerization of the complex; phosphorylated [Source:SGD;Acc:S000005999]
P	YPL079W	RPL21B	3959	-535.5	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl21Ap and has similarity to rat L21 ribosomal protein [Source:SGD;Acc:S000006000]
P	YPL080C	YPL080C	2	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006001]
P	YPL081W	RPS9A	4073	-421.2	4	Protein component of the small (40S) ribosomal subunit; nearly identical to Rps9Bp and has similarity to E. coli S4 and rat S9 ribosomal proteins [Source:SGD;Acc:S000006002]
P	YPL082C	MOT1	983	-780	4	Essential abundant protein involved in regulation of transcription, removes Spt15p (TBP) from DNA via its C-terminal ATPase activity, forms a complex with TBP that binds TATA DNA with high affinity but with altered specificity [Source:SGD;Acc:S000006003]
P	YPL083C	SEN54	99	-106.2	4	Subunit of the tRNA splicing endonuclease, which is composed of Sen2p, Sen15p, Sen34p, and Sen54p [Source:SGD;Acc:S000006004]
P	YPL084W	BRO1	985	-627.8	4	Cytoplasmic class E vacuolar protein sorting (VPS) factor that coordinates deubiquitination in the multivesicular body (MVB) pathway by recruiting Doa4p to endosomes [Source:SGD;Acc:S000006005]
P	YPL085W	SEC16	2158	-1958	4	COPII vesicle coat protein required for ER transport vesicle budding; Sec16p is bound to the periphery of ER membranes and may act to stabilize initial COPII complexes; interacts with Sec23p, Sec24p and Sec31p [Source:SGD;Acc:S000006006]
P	YPL086C	ELP3	1009	-480.2	4	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; exhibits histone acetyltransferase activity that is directed to histones H3 and H4; disruption confers resistance to K. lactis zymotoxin [Source:SGD;Acc:S000006007]
P	YPL087W	YDC1	213	-126.7	4	Alkaline dihydroceramidase, involved in sphingolipid metabolism; preferentially hydrolyzes dihydroceramide to a free fatty acid and dihydrosphingosine; has a minor reverse activity [Source:SGD;Acc:S000006008]
P	YPL088W	YPL088W	161	-142.9	4	Putative aryl alcohol dehydrogenase; transcription is activated by paralogous transcription factors Yrm1p and Yrr1p along with genes involved in multidrug resistance [Source:SGD;Acc:S000006009]
P	YPL089C	RLM1	363	-1548	4	MADS-box transcription factor, component of the protein kinase C-mediated MAP kinase pathway involved in the maintenance of cell integrity; phosphorylated and activated by the MAP-kinase Slt2p [Source:SGD;Acc:S000006010]
P	YPL090C	RPS6A	4957	-768	4	Protein component of the small (40S) ribosomal subunit; identical to Rps6Bp and has similarity to rat S6 ribosomal protein [Source:SGD;Acc:S000006011]
P	YPL091W	GLR1	2107	-701.2	4	Cytosolic and mitochondrial glutathione oxidoreductase, converts oxidized glutathione to reduced glutathione; mitochondrial but not cytosolic form has a role in resistance to hyperoxia [Source:SGD;Acc:S000006012]
P	YPL092W	SSU1	72	-78.1	4	Plasma membrane sulfite pump involved in sulfite metabolism and required for efficient sulfite efflux; major facilitator superfamily protein [Source:SGD;Acc:S000006013]
P	YPL093W	NOG1	2362	-462	4	Putative GTPase that associates with free 60S ribosomal subunits in the nucleolus and is required for 60S ribosomal subunit biogenesis; constituent of 66S pre-ribosomal particles; member of the ODN family of nucleolar G-proteins [Source:SGD;Acc:S000006014]
P	YPL094C	SEC62	607	-120.8	4	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER [Source:SGD;Acc:S000006015]
P	YPL095C	EEB1	108	-81.6	4	Acyl-coenzymeA:ethanol O-acyltransferase responsible for the major part of medium-chain fatty acid ethyl ester biosynthesis during fermentation; possesses short-chain esterase activity; may be involved in lipid metabolism and detoxification [Source:SGD;Acc:S000006016]
P	YPL096C-A	ERI1	0	nf	1	Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein [Source:SGD;Acc:S000028423]
P	YPL096W	PNG1	262	-190.1	4	Conserved peptide N-glycanase required for deglycosylation of misfolded glycoproteins during proteasome-dependent degradation; localizes to the cytoplasm and nucleus; activity is enhanced by interaction with Rad23p [Source:SGD;Acc:S000006017]
P	YPL097W	MSY1	313	-249.1	4	Mitochondrial tyrosyl-tRNA synthetase [Source:SGD;Acc:S000006018]
P	YPL098C	MGR2	351	-95.4	4	Protein required for growth of cells lacking the mitochondrial genome [Source:SGD;Acc:S000006019]
P	YPL099C	INA17	246	-152	4	Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000006020]
P	YPL100W	ATG21	417	-222.4	4	Phosphoinositide binding protein required for vesicle formation in the cytoplasm-to-vacuole targeting (Cvt) pathway; binds both phosphatidylinositol (3,5)-bisphosphate and phosphatidylinositol 3-phosphate; WD-40 repeat protein [Source:SGD;Acc:S000006021]
P	YPL101W	ELP4	363	-209.3	4	Subunit of Elongator complex, which is required for modification of wobble nucleosides in tRNA; required for Elongator structural integrity [Source:SGD;Acc:S000006022]
P	YPL102C	YPL102C	4	-1.4	1	Dubious open reading frame, not conserved in closely related Saccharomyces species; deletion mutation enhances replication of Brome mosaic virus in S. cerevisiae, but this is likely due to effects on the overlapping gene ELP4 [Source:SGD;Acc:S000006023]
P	YPL103C	FMP30	151	-160.9	4	Mitochondrial inner membrane protein with a role in maintaining mitochondrial morphology and normal cardiolipin levels; proposed to be involved in N-acylethanolamine metabolism; related to mammalian N-acylPE-specific phospholipase D [Source:SGD;Acc:S000006024]
P	YPL104W	MSD1	281	-293.6	4	Mitochondrial aspartyl-tRNA synthetase, required for acylation of aspartyl-tRNA; yeast and bacterial aspartyl-, asparaginyl-, and lysyl-tRNA synthetases contain regions with high sequence similarity, suggesting a common ancestral gene [Source:SGD;Acc:S000006025]
P	YPL105C	SYH1	1005	-479.8	4	Protein of unknown function that influences nuclear pore distribution; co-purifies with ribosomes; contains a GYF domain, which bind proline-rich sequences; deletion extends chronological lifespan [Source:SGD;Acc:S000006026]
P	YPL106C	SSE1	5321	-2291.1	4	ATPase that is a component of the heat shock protein Hsp90 chaperone complex; binds unfolded proteins; member of the heat shock protein 70 (HSP70) family; localized to the cytoplasm [Source:SGD;Acc:S000006027]
P	YPL107W	YPL107W	83	-53.3	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YPL107W is not an essential gene [Source:SGD;Acc:S000006028]
P	YPL108W	YPL108W	63	-47.3	4	Cytoplasmic protein of unknown function; non-essential gene that is induced in a GDH1 deleted strain with altered redox metabolism; GFP-fusion protein is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000006029]
P	YPL109C	YPL109C	131	-279.9	4	Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000006030]
P	YPL110C	GDE1	924	-544.5	4	Glycerophosphocholine (GroPCho) phosphodiesterase; hydrolyzes GroPCho to choline and glycerolphosphate, for use as a phosphate source and as a precursor for phosphocholine synthesis; may interact with ribosomes [Source:SGD;Acc:S000006031]
P	YPL111W	CAR1	1670	-312.9	4	Arginase, responsible for arginine degradation, expression responds to both induction by arginine and nitrogen catabolite repression; disruption enhances freeze tolerance [Source:SGD;Acc:S000006032]
P	YPL112C	PEX25	931	-280.5	4	Peripheral peroxisomal membrane peroxin required for the regulation of peroxisome size and maintenance, recruits GTPase Rho1p to peroxisomes, induced by oleate, interacts with homologous protein Pex27p [Source:SGD;Acc:S000006033]
P	YPL113C	YPL113C	112	-150.7	4	Glyoxylate reductase; acts on glyoxylate and hydroxypyruvate substrates; YPL113C is not an essential gene [Source:SGD;Acc:S000006034]
P	YPL114W	YPL114W	0	nf	1	Dubious open reading frame, unlikely to encode a functional protein; largely overlaps ORF YPL113C; diploid deletion in BY4743 strain background exhibits high budding index [Source:SGD;Acc:S000006035]
P	YPL115C	BEM3	617	-387.8	4	Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly [Source:SGD;Acc:S000006036]
P	YPL116W	HOS3	888	-334.4	4	Trichostatin A-insensitive homodimeric histone deacetylase (HDAC) with specificity in vitro for histones H3, H4, H2A, and H2B; similar to Hda1p, Rpd3p, Hos1p, and Hos2p; deletion results in increased histone acetylation at rDNA repeats [Source:SGD;Acc:S000006037]
P	YPL117C	IDI1	1810	-275.7	4	Isopentenyl diphosphate:dimethylallyl diphosphate isomerase (IPP isomerase), catalyzes an essential activation step in the isoprenoid biosynthetic pathway; required for viability [Source:SGD;Acc:S000006038]
P	YPL118W	MRP51	601	-304.1	4	Mitochondrial ribosomal protein of the small subunit; MRP51 exhibits genetic interactions with mutations in the COX2 and COX3 mRNA 5'-untranslated leader sequences [Source:SGD;Acc:S000006039]
P	YPL119C	DBP1	2509	-371.6	4	Putative ATP-dependent RNA helicase of the DEAD-box protein family; mutants show reduced stability of the 40S ribosomal subunit scanning through 5' untranslated regions of mRNAs [Source:SGD;Acc:S000006040]
P	YPL119C-A	YPL119C-A	2	-2.2	2	Putative protein of unknown function; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028859]
P	YPL120W	VPS30	272	-286.4	4	Subunit of phosphatidylinositol (PtdIns) 3-kinase complexes I and II; Complex I is essential in autophagy and Complex II is required for vacuolar protein sorting; ortholog of the higher eukaryotic gene Beclin 1 [Source:SGD;Acc:S000006041]
P	YPL121C	MEI5	68	-13	2	Meiosis specific protein involved in DMC1-dependent meiotic recombination, forms heterodimer with Sae3p; proposed to be an assembly factor for Dmc1p [Source:SGD;Acc:S000006042]
P	YPL122C	TFB2	390	-251	4	Subunit of TFIIH and nucleotide excision repair factor 3 complexes, involved in transcription initiation, required for nucleotide excision repair, similar to 52 kDa subunit of human TFIIH [Source:SGD;Acc:S000006043]
P	YPL123C	RNY1	466	-384.9	4	Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity [Source:SGD;Acc:S000006044]
P	YPL124W	SPC29	477	-142.8	4	Inner plaque spindle pole body (SPB) component, links the central plaque component Spc42p to the inner plaque component Spc110p; required for SPB duplication [Source:SGD;Acc:S000006045]
P	YPL125W	KAP120	736	-572.7	4	Karyopherin responsible for the nuclear import of ribosome maturation factor Rfp1p [Source:SGD;Acc:S000006046]
P	YPL126W	NAN1	1699	-454	4	U3 snoRNP protein, component of the small (ribosomal) subunit (SSU) processosome containing U3 snoRNA; required for the biogenesis of18S rRNA [Source:SGD;Acc:S000006047]
P	YPL127C	HHO1	1486	-335.1	4	Histone H1, a linker histone required for nucleosome packaging at restricted sites; suppresses DNA repair involving homologous recombination; not required for telomeric silencing, basal transcriptional repression, or efficient sporulation [Source:SGD;Acc:S000006048]
P	YPL128C	TBF1	647	-308.7	4	Telobox-containing general regulatory factor; binds TTAGGG repeats within subtelomeric anti-silencing regions (STARs), blocking silent chromatin propagation; binds majority of snoRNA gene promoters, required for full snoRNA expression; caps DSB flan   long T2AG3 repeats and blocks checkpoint activation [Source:SGD;Acc:S000006049]
P	YPL129W	TAF14	1459	-740.5	4	Subunit of TFIID, TFIIF, INO80, SWI/SNF, and NuA3 complexes, involved in RNA polymerase II transcription initiation and in chromatin modification; contains a YEATS domain [Source:SGD;Acc:S000006050]
P	YPL130W	SPO19	2	-4.6	2	Meiosis-specific prospore protein; required to produce bending force necessary for proper assembly of the prospore membrane during sporulation; identified as a weak high-copy suppressor of the spo1-1 ts mutation [Source:SGD;Acc:S000006051]
P	YPL131W	RPL5	4710	-1339.7	4	Protein component of the large (60S) ribosomal subunit with similarity to E. coli L18 and rat L5 ribosomal proteins; binds 5S rRNA and is required for 60S subunit assembly [Source:SGD;Acc:S000006052]
P	YPL132W	COX11	280	-211.3	4	Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p [Source:SGD;Acc:S000006053]
P	YPL133C	RDS2	173	-167.4	4	Transcription factor involved in regulating gluconeogenesis and glyoxylate cycle genes; member of the zinc cluster family of proteins; confers resistance to ketoconazole [Source:SGD;Acc:S000006054]
P	YPL134C	ODC1	415	-318.6	4	Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for lysine and glutamate biosynthesis and lysine catabolism; suppresses, in multicopy, an fmc1 null mutation [Source:SGD;Acc:S000006055]
P	YPL135C-A	YPL135C-A	0	nf	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028720]
P	YPL135W	ISU1	501	-98.1	4	Conserved protein of the mitochondrial matrix, performs a scaffolding function during assembly of iron-sulfur clusters, interacts physically and functionally with yeast frataxin (Yfh1p); isu1 isu2 double mutant is inviable [Source:SGD;Acc:S000006056]
P	YPL136W	YPL136W	11	-5.4	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene GIP3/YPL137C [Source:SGD;Acc:S000006057]
P	YPL137C	GIP3	888	-3009.9	4	Glc7-interacting protein whose overexpression relocalizes Glc7p from the nucleus and prevents chromosome segregation; may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000006058]
P	YPL138C	SPP1	202	-177.2	4	Subunit of COMPASS (Set1C), a complex which methylates histone H3 on lysine 4 and is required in telomeric transcriptional silencing; interacts with Orc2p; PHD finger domain protein similar to human CGBP, an unmethylated CpG binding protein [Source:SGD;Acc:S000006059]
P	YPL139C	UME1	561	-291.9	4	Negative regulator of meiosis, required for repression of a subset of meiotic genes during vegetative growth, binding of histone deacetylase Rpd3p required for activity, contains a NEE box and a WD repeat motif; homologous with Wtm1p, Wtm2p [Source:SGD;Acc:S000006060]
P	YPL140C	MKK2	149	-277.8	4	Mitogen-activated kinase kinase involved in protein kinase C signaling pathway that controls cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk1p [Source:SGD;Acc:S000006061]
P	YPL141C	FRK1	168	-1270.6	4	Putative protein kinase; similar to Kin4p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; interacts with rRNA transcription and ribosome biogenesis factors and the long chain fatty acyl-CoA synthetase Faa3 [Source:SGD;Acc:S000006062]
P	YPL142C	YPL142C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF RPL33A/YPL143W, a component of the large (60S) ribosomal subunit [Source:SGD;Acc:S000006063]
P	YPL143W	RPL33A	3449	-233.4	4	N-terminally acetylated ribosomal protein L37 of the large (60S) ribosomal subunit, nearly identical to Rpl33Bp and has similarity to rat L35a; rpl33a null mutant exhibits slow growth while rpl33a rpl33b double null mutant is inviable [Source:SGD;Acc:S000006064]
P	YPL144W	POC4	244	-58	4	Component of a heterodimeric Poc4p-Irc25p chaperone involved in assembly of alpha subunits into the 20S proteasome; may regulate formation of proteasome isoforms with alternative subunits under different conditions [Source:SGD;Acc:S000006065]
P	YPL145C	KES1	2238	-542.1	4	Member of the oxysterol binding protein family, which includes seven yeast homologs; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex [Source:SGD;Acc:S000006066]
P	YPL146C	NOP53	724	-202.2	4	Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired [Source:SGD;Acc:S000006067]
P	YPL147W	PXA1	72	-138.5	4	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter and ALD-related proteins [Source:SGD;Acc:S000006068]
P	YPL148C	PPT2	29	-39.2	4	Phosphopantetheine:protein transferase (PPTase), activates mitochondrial acyl carrier protein (Acp1p) by phosphopantetheinylation [Source:SGD;Acc:S000006069]
P	YPL149W	ATG5	47	-62	4	Conserved protein involved in autophagy and the Cvt pathway; undergoes conjugation with Atg12p to form a complex involved in Atg8p lipidation; conjugated Atg12p also forms a complex with Atg16p that is essential for autophagosome formation [Source:SGD;Acc:S000006070]
P	YPL150W	YPL150W	236	-709.3	4	Putative protein kinase of unknown cellular role; binds phosphatidylinositols and cardiolipin in a large-scale study [Source:SGD;Acc:S000006071]
P	YPL151C	PRP46	211	-334.1	4	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs [Source:SGD;Acc:S000006072]
P	YPL152W	RRD2	182	-122.6	4	Activator of the phosphotyrosyl phosphatase activity of PP2A,peptidyl-prolyl cis/trans-isomerase; regulates G1 phase progression, the osmoresponse, microtubule dynamics; subunit of the Tap42p-Pph21p-Rrd2p complex [Source:SGD;Acc:S000006073]
P	YPL152W-A	YPL152W-A	0	nf	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028721]
P	YPL153C	RAD53	404	-1479.1	4	Protein kinase, required for cell-cycle arrest in response to DNA damage; activated by trans autophosphorylation when interacting with hyperphosphorylated Rad9p; also interacts with ARS1 and plays a role in initiation of DNA replication [Source:SGD;Acc:S000006074]
P	YPL154C	PEP4	2868	-1036.2	4	Vacuolar aspartyl protease (proteinase A), required for the posttranslational precursor maturation of vacuolar proteinases; important for protein turnover after oxidative damage; synthesized as a zymogen, self-activates [Source:SGD;Acc:S000006075]
P	YPL155C	KIP2	208	-100.1	4	Kinesin-related motor protein involved in mitotic spindle positioning, stabilizes microtubules by targeting Bik1p to the plus end; Kip2p levels are controlled during the cell cycle [Source:SGD;Acc:S000006076]
P	YPL156C	PRM4	114	-77.9	4	Pheromone-regulated protein proposed to be involved in mating; predicted to have 1 transmembrane segment; transcriptionally regulated by Ste12p during mating and by Cat8p during the diauxic shift [Source:SGD;Acc:S000006077]
P	YPL157W	TGS1	120	-60.4	4	Trimethyl guanosine synthase, conserved nucleolar methyl transferase that converts the m(7)G cap structure of snRNAs, snoRNAs, and telomerase TLC1 RNA to m(2,2,7)G; also required for nucleolar assembly and splicing of meiotic pre-mRNAs [Source:SGD;Acc:S000006078]
P	YPL158C	AIM44	85	-52.6	4	Protein of unknown function; GFP-fusion protein localizes to the bud neck; transcription is regulated by Swi5p; null mutant displays elevated frequency of mitochondrial genome loss [Source:SGD;Acc:S000006079]
P	YPL159C	PET20	110	-26.6	3	Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome [Source:SGD;Acc:S000006080]
P	YPL160W	CDC60	3602	-1984.4	4	Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA [Source:SGD;Acc:S000006081]
P	YPL161C	BEM4	352	-228.1	4	Protein involved in establishment of cell polarity and bud emergence; interacts with the Rho1p small GTP-binding protein and with the Rho-type GTPase Cdc42p; involved in maintenance of proper telomere length [Source:SGD;Acc:S000006082]
P	YPL162C	YPL162C	20	-24.5	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the membrane of vacuole with cell cycle-correlated morphology [Source:SGD;Acc:S000006083]
P	YPL163C	SVS1	3	-13	2	Cell wall and vacuolar protein, required for wild-type resistance to vanadate [Source:SGD;Acc:S000006084]
P	YPL164C	MLH3	70	-124	3	Protein involved in DNA mismatch repair and crossing-over during meiotic recombination; forms a complex with Mlh1p; mammalian homolog is implicated mammalian microsatellite instability [Source:SGD;Acc:S000006085]
P	YPL165C	SET6	10	-2.3	2	SET domain protein of unknown function; deletion heterozygote is sensitive to compounds that target ergosterol biosynthesis, may be involved in compound availability [Source:SGD;Acc:S000006086]
P	YPL166W	ATG29	138	-69.5	4	Autophagy-specific protein that is required for recruitment of other ATG proteins to the pre-autophagosomal structure (PAS); interacts with Atg17p and localizas to the PAS in a manner interdependent with Atg17p and Cis1p; not conserved [Source:SGD;Acc:S000006087]
P	YPL167C	REV3	81	-32.7	2	Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair [Source:SGD;Acc:S000006088]
P	YPL168W	YPL168W	86	-138.4	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; expression may be cell cycle-regulated [Source:SGD;Acc:S000006089]
P	YPL169C	MEX67	1279	-798.5	4	Poly(A)RNA binding protein involved in nuclear mRNA export, component of the nuclear pore; ortholog of human TAP [Source:SGD;Acc:S000006090]
P	YPL170W	DAP1	735	-123.7	4	Heme-binding protein involved in regulation of cytochrome P450 protein Erg11p; damage response protein, related to mammalian membrane progesterone receptors; mutations lead to defects in telomeres, mitochondria, and sterol synthesis [Source:SGD;Acc:S000006091]
P	YPL171C	OYE3	1085	-375	4	Conserved NADPH oxidoreductase containing flavin mononucleotide (FMN), homologous to Oye2p with different ligand binding and catalytic properties; has potential roles in oxidative stress response and programmed cell death [Source:SGD;Acc:S000006092]
P	YPL172C	COX10	81	-82	4	Heme A:farnesyltransferase, catalyzes the first step in the conversion of protoheme to the heme A prosthetic group required for cytochrome c oxidase activity; human ortholog is associated with mitochondrial disorders [Source:SGD;Acc:S000006093]
P	YPL173W	MRPL40	676	-156.7	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000006094]
P	YPL174C	NIP100	26	-44.4	2	Large subunit of the dynactin complex, which is involved in partitioning the mitotic spindle between mother and daughter cells; putative ortholog of mammalian p150(glued) [Source:SGD;Acc:S000006095]
P	YPL175W	SPT14	97	-58.5	4	UDP-GlcNAc-binding and catalytic subunit of the enzyme that mediates the first step in glycosylphosphatidylinositol (GPI) biosynthesis, mutations cause defects in transcription and in biogenesis of cell wall proteins [Source:SGD;Acc:S000006096]
P	YPL176C	TRE1	150	-169.1	4	Plasma membrane protein that binds to Bsd2p and regulates ubiquitylation and vacuolar degradation of the metal transporter Smf1p; function is redundant with that of Tre2p; has similarity to transferrin receptors [Source:SGD;Acc:S000006097]
P	YPL177C	CUP9	53	-51.6	4	Homeodomain-containing transcriptional repressor of PTR2, which encodes a major peptide transporter; imported peptides activate ubiquitin-dependent proteolysis, resulting in degradation of Cup9p and de-repression of PTR2 transcription [Source:SGD;Acc:S000006098]
P	YPL178W	CBC2	583	-207.2	4	Small subunit of the heterodimeric cap binding complex that also contains Sto1p, component of the spliceosomal commitment complex; interacts with Npl3p, possibly to package mRNA for export from the nucleus; contains an RNA-binding motif [Source:SGD;Acc:S000006099]
P	YPL179W	PPQ1	166	-751.3	4	Putative protein serine/threonine phosphatase; null mutation enhances efficiency of translational suppressors [Source:SGD;Acc:S000006100]
P	YPL180W	TCO89	756	-1107.7	4	Subunit of TORC1 (Tor1p or Tor2p-Kog1p-Lst8p-Tco89p), a complex that regulates growth in response to nutrient availability; cooperates with Ssd1p in the maintenance of cellular integrity; deletion strains are hypersensitive to rapamycin [Source:SGD;Acc:S000006101]
P	YPL181W	CTI6	311	-379.3	4	Protein that relieves transcriptional repression by binding to the Cyc8p-Tup1p corepressor and recruiting the SAGA complex to the repressed promoter; contains a PHD finger domain [Source:SGD;Acc:S000006102]
P	YPL182C	YPL182C	7	-3.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene CTI6/YPL181W [Source:SGD;Acc:S000006103]
P	YPL183C	RTT10	675	-460.7	4	WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rrt2p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; has a role in regulation of Ty1 transposition; human ortholo  DR6 [Source:SGD;Acc:S000006104]
P	YPL183W-A	RTC6	42	-24.1	4	Protein involved translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein encoded in the nucleus [Source:SGD;Acc:S000007224]
P	YPL184C	MRN1	840	-415.8	4	RNA-binding protein proposed to be involved in translational regulation; binds specific categories of mRNAs, including those that contain upstream open reading frames (uORFs) and internal ribosome entry sites (IRES) [Source:SGD;Acc:S000006105]
P	YPL185W	YPL185W	5	-1.4	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene UIP4/YPL186C [Source:SGD;Acc:S000006106]
P	YPL186C	UIP4	458	-265.4	4	Protein that interacts with Ulp1p, a Ubl (ubiquitin-like protein)-specific protease for Smt3p protein conjugates; detected in a phosphorylated state in the mitochondrial outer membrane; also detected in ER and nuclear envelope [Source:SGD;Acc:S000006107]
P	YPL187W	MF(ALPHA)1	65	-40.5	4	MF(ALPHA)1, Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)2, although MF(ALPHA)1 produces most alpha-factor [Source:SGD;Acc:S000006108]
P	YPL188W	POS5	495	-188.5	4	Mitochondrial NADH kinase, phosphorylates NADH; also phosphorylates NAD(+) with lower specificity; required for the response to oxidative stress [Source:SGD;Acc:S000006109]
P	YPL189C-A	COA2	0	nf	1	Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p [Source:SGD;Acc:S000028527]
P	YPL189W	GUP2	45	-16.7	4	Probable membrane protein with a possible role in proton symport of glycerol; member of the MBOAT family of putative membrane-bound O-acyltransferases; Gup1p homolog [Source:SGD;Acc:S000006110]
P	YPL190C	NAB3	1149	-463	4	Single stranded RNA binding protein; subunit of Nrd1 complex (Nrd1p-Nab3p-Sen1p); acidic ribonucleoprotein; required for termination of non-poly(A) transcripts and efficient splicing [Source:SGD;Acc:S000006111]
P	YPL191C	YPL191C	98	-85.2	4	Putative protein of unknown function; diploid deletion strain exhibits high budding index; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000006112]
P	YPL192C	PRM3	22	-31.8	4	Pheromone-regulated protein required for nuclear envelope fusion during karyogamy; localizes to the outer face of the nuclear membrane; interacts with Kar5p at the spindle pole body [Source:SGD;Acc:S000006113]
P	YPL193W	RSA1	219	-118.2	4	Protein involved in the assembly of 60S ribosomal subunits; functionally interacts with Dbp6p; functions in a late nucleoplasmic step of the assembly [Source:SGD;Acc:S000006114]
P	YPL194W	DDC1	93	-224.1	4	DNA damage checkpoint protein, part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate [Source:SGD;Acc:S000006115]
P	YPL195W	APL5	1513	-626.2	4	Delta adaptin-like subunit of the clathrin associated protein complex (AP-3); functions in transport of alkaline phosphatase to the vacuole via the alternate pathway, suppressor of loss of casein kinase 1 function [Source:SGD;Acc:S000006116]
P	YPL196W	OXR1	249	-106.9	4	Protein of unknown function required for normal levels of resistance to oxidative damage, null mutants are sensitive to hydrogen peroxide; member of a conserved family of proteins found in eukaryotes [Source:SGD;Acc:S000006117]
P	YPL197C	YPL197C	3	-2.2	2	Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the ribosomal gene RPB7B [Source:SGD;Acc:S000006118]
P	YPL198W	RPL7B	4690	-745.4	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl7Ap and has similarity to E. coli L30 and rat L7 ribosomal proteins; contains a conserved C-terminal Nucleic acid Binding Domain (NDB2) [Source:SGD;Acc:S000006119]
P	YPL199C	YPL199C	627	-124.3	4	Putative protein of unknown function, predicted to be palmitoylated [Source:SGD;Acc:S000006120]
P	YPL200W	CSM4	4	-2.4	2	Protein required for accurate chromosome segregation during meiosis; involved in meiotic telomere clustering (bouquet formation) and telomere-led rapid prophase movements [Source:SGD;Acc:S000006121]
P	YPL201C	YIG1	11	-24.6	2	Protein that interacts with glycerol 3-phosphatase and plays a role in anaerobic glycerol production; localizes to the nucleus and cytosol [Source:SGD;Acc:S000006122]
P	YPL202C	AFT2	34	-26.7	4	Iron-regulated transcriptional activator; activates genes involved in intracellular iron use and required for iron homeostasis and resistance to oxidative stress; similar to Aft1p [Source:SGD;Acc:S000006123]
P	YPL203W	TPK2	505	-1136.5	4	cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk3p; localizes to P-bodies during stationary phase [Source:SGD;Acc:S000006124]
P	YPL204W	HRR25	1215	-1878.5	4	Protein kinase involved in regulating diverse events including vesicular trafficking, DNA repair, and chromosome segregation; binds the CTD of RNA pol II; homolog of mammalian casein kinase 1delta (CK1delta) [Source:SGD;Acc:S000006125]
P	YPL205C	YPL205C	4	-1.9	1	Hypothetical protein; deletion of locus affects telomere length [Source:SGD;Acc:S000006126]
P	YPL206C	PGC1	551	-178.5	4	Phosphatidyl Glycerol phospholipase C; regulates the phosphatidylglycerol (PG) content via a phospholipase C-type degradation mechanism; contains glycerophosphodiester phosphodiesterase motifs [Source:SGD;Acc:S000006127]
P	YPL207W	TYW1	901	-418	4	Iron-sulfer protein required for synthesis of Wybutosine modified tRNA; Wybutosine is a modified guanosine found at the 3'-position adjacent to the anticodon of phenylalanine tRNA which supports reading frame maintenance by stabilizing codon-anticod  eractions; induction by Yap5p in response to iron provides protection from high iron toxicity; overexpression results in increased cellular iron [Source:SGD;Acc:S000006128]
P	YPL208W	RKM1	421	-226	4	SET-domain lysine-N-methyltransferase, catalyzes the formation of dimethyllysine residues on the large ribsomal subunit protein L23a (RPL23A and RPL23B) [Source:SGD;Acc:S000006129]
P	YPL209C	IPL1	59	-480.9	4	Aurora kinase subunit of the conserved chromosomal passenger complex (CPC; Ipl1p-Sli15p-Bir1p-Nbl1p), involved in regulating kinetochore-microtubule attachments; helps maintain condensed chromosomes during anaphase and early telophase; required for   hesion and prevention of multipolar spindle formation [Source:SGD;Acc:S000006130]
P	YPL210C	SRP72	1512	-434	4	Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane [Source:SGD;Acc:S000006131]
P	YPL211W	NIP7	1076	-172.1	4	Nucleolar protein required for 60S ribosome subunit biogenesis, constituent of 66S pre-ribosomal particles; physically interacts with Nop8p and the exosome subunit Rrp43p [Source:SGD;Acc:S000006132]
P	YPL212C	PUS1	1475	-529.4	4	tRNA:pseudouridine synthase, introduces pseudouridines at positions 26-28, 34-36, 65, and 67 of tRNA; nuclear protein that appears to be involved in tRNA export; also acts on U2 snRNA [Source:SGD;Acc:S000006133]
P	YPL213W	LEA1	325	-164.7	4	Component of U2 snRNP; disruption causes reduced U2 snRNP levels; physically interacts with Msl1p; putative homolog of human U2A' snRNP protein [Source:SGD;Acc:S000006134]
P	YPL214C	THI6	456	-368.4	4	Bifunctional enzyme with thiamine-phosphate pyrophosphorylase and 4-methyl-5-beta-hydroxyethylthiazole kinase activities, required for thiamine biosynthesis; GFP-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000006135]
P	YPL215W	CBP3	684	-302	4	Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with   synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex [Source:SGD;Acc:S000006136]
P	YPL216W	YPL216W	52	-19.1	2	Putative protein of unknown function; YPL216W is not an essential gene [Source:SGD;Acc:S000006137]
P	YPL217C	BMS1	1650	-580.4	4	GTPase required for synthesis of 40S ribosomal subunits and for processing the 35S pre-rRNA at sites A0, A1, and A2; interacts with Rcl1p, which stimulates its GTPase and U3 snoRNA binding activities; has similarity to Tsr1p [Source:SGD;Acc:S000006138]
P	YPL218W	SAR1	2678	-651.3	4	GTPase, GTP-binding protein of the ARF family, component of COPII coat of vesicles; required for transport vesicle formation during ER to Golgi protein transport [Source:SGD;Acc:S000006139]
P	YPL219W	PCL8	239	-231.7	4	Cyclin, interacts with Pho85p cyclin-dependent kinase (Cdk) to phosphorylate and regulate glycogen synthase, also activates Pho85p for Glc8p phosphorylation [Source:SGD;Acc:S000006140]
P	YPL220W	RPL1A	4240	-655.3	4	N-terminally acetylated protein component of the large (60S) ribosomal subunit, nearly identical to Rpl1Bp and has similarity to E. coli L1 and rat L10a ribosomal proteins; rpl1a rpl1b double null mutation is lethal [Source:SGD;Acc:S000006141]
P	YPL221W	FLC1	496	-137.3	4	Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance [Source:SGD;Acc:S000006142]
P	YPL222C-A	YPL222C-A	0	nf	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028722]
P	YPL222W	FMP40	403	-492.2	4	Putative protein of unknown function; proposed to be involved in responding to environmental stresses; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000006143]
P	YPL223C	GRE1	327	-467.9	4	Hydrophilin of unknown function; stress induced (osmotic, ionic, oxidative, heat shock and heavy metals); regulated by the HOG pathway [Source:SGD;Acc:S000006144]
P	YPL224C	MMT2	185	-118.9	4	Putative metal transporter involved in mitochondrial iron accumulation; closely related to Mmt1p [Source:SGD;Acc:S000006145]
P	YPL225W	YPL225W	1890	-337.2	4	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000006146]
P	YPL226W	NEW1	3230	-1637.8	4	ATP binding cassette protein that cosediments with polysomes and is required for biogenesis of the small ribosomal subunit; Asn/Gln-rich rich region supports [NU+] prion formation and susceptibility to [PSI+] prion induction [Source:SGD;Acc:S000006147]
P	YPL227C	ALG5	304	-160.8	4	UDP-glucose:dolichyl-phosphate glucosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum [Source:SGD;Acc:S000006148]
P	YPL228W	CET1	964	-444.3	4	Beta (RNA 5'-triphosphatase) subunit of the mRNA capping enzyme, a heterodimer (the other subunit is CEG1, a guanylyltransferase) involved in adding the 5' cap to mRNA; the mammalian enzyme is a single bifunctional polypeptide [Source:SGD;Acc:S000006149]
P	YPL229W	YPL229W	152	-57.6	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YPL229W is not an essential gene [Source:SGD;Acc:S000006150]
P	YPL230W	USV1	120	-73.6	4	Putative transcription factor containing a C2H2 zinc finger; mutation affects transcriptional regulation of genes involved in growth on non-fermentable carbon sources, response to salt stress and cell wall biosynthesis [Source:SGD;Acc:S000006151]
P	YPL231W	FAS2	4657	-5999	4	Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities [Source:SGD;Acc:S000006152]
P	YPL232W	SSO1	1206	-375.3	4	Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p [Source:SGD;Acc:S000006153]
P	YPL233W	NSL1	108	-53.9	4	Essential component of the MIND kinetochore complex (Mtw1p Including Nnf1p-Nsl1p-Dsn1p) which joins kinetochore subunits contacting DNA to those contacting microtubules; required for accurate chromosome segregation [Source:SGD;Acc:S000006154]
P	YPL234C	VMA11	284	-61.6	4	Vacuolar ATPase V0 domain subunit c', involved in proton transport activity; hydrophobic integral membrane protein (proteolipid) containing four transmembrane segments; N and C termini are in the vacuolar lumen [Source:SGD;Acc:S000006155]
P	YPL235W	RVB2	2391	-2407.2	4	Essential protein involved in transcription regulation; component of chromatin remodeling complexes; required for assembly and function of the INO80 complex; also referred to as reptin; member of the RUVB-like protein family [Source:SGD;Acc:S000006156]
P	YPL236C	ENV7	101	-147.7	4	Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing; has sequence similarity with the human serine/threonine protein kinase STK16 [Source:SGD;Acc:S000006157]
P	YPL237W	SUI3	2756	-596.9	4	Beta subunit of the translation initiation factor eIF2, involved in the identification of the start codon; proposed to be involved in mRNA binding [Source:SGD;Acc:S000006158]
P	YPL238C	YPL238C	1	-0.7	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified essential gene SUI3/YPL237W [Source:SGD;Acc:S000006159]
P	YPL239W	YAR1	1311	-261.7	4	Cytoplasmic ankyrin-repeat containing protein of unknown function, proposed to link the processes of 40S ribosomal subunit biogenesis and adaptation to osmotic and oxidative stress; expression repressed by heat shock [Source:SGD;Acc:S000006160]
P	YPL240C	HSP82	5786	-2090.8	4	Hsp90 chaperone required for pheromone signaling and negative regulation of Hsf1p; docks with Tom70p for mitochondrial preprotein delivery; promotes telomerase DNA binding and nucleotide addition; interacts with Cns1p, Cpr6p, Cpr7p, Sti1p [Source:SGD;Acc:S000006161]
P	YPL241C	CIN2	132	-72.8	4	GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2 [Source:SGD;Acc:S000006162]
P	YPL242C	IQG1	209	-201.9	4	Essential protein required for determination of budding pattern, promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family [Source:SGD;Acc:S000006163]
P	YPL243W	SRP68	1657	-402	4	Core component of the signal recognition particle (SRP) ribonucleoprotein (RNP) complex that functions in targeting nascent secretory proteins to the endoplasmic reticulum (ER) membrane [Source:SGD;Acc:S000006164]
P	YPL244C	HUT1	37	-49.9	4	Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 [Source:SGD;Acc:S000006165]
P	YPL245W	YPL245W	578	-275.5	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the nucleus and the cytoplasm [Source:SGD;Acc:S000006166]
P	YPL246C	RBD2	191	-133.8	4	Possible rhomboid protease, has similarity to eukaryotic rhomboid proteases including Pcp1p [Source:SGD;Acc:S000006167]
P	YPL247C	YPL247C	597	-253.4	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; similar to the petunia WD repeat protein an11; overexpression causes a cell cycle delay or arrest [Source:SGD;Acc:S000006168]
P	YPL248C	GAL4	40	-83.9	4	DNA-binding transcription factor required for the activation of the GAL genes in response to galactose; repressed by Gal80p and activated by Gal3p [Source:SGD;Acc:S000006169]
P	YPL249C	GYP5	876	-484	4	GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting   p to the bud tip during polarized growth [Source:SGD;Acc:S000006170]
P	YPL249C-A	RPL36B	3457	-342.5	4	Protein component of the large (60S) ribosomal subunit, nearly identical to Rpl36Ap and has similarity to rat L36 ribosomal protein; binds to 5.8 S rRNA [Source:SGD;Acc:S000006438]
P	YPL250C	ICY2	43	-15.4	2	Protein of unknown function; mobilized into polysomes upon a shift from a fermentable to nonfermentable carbon source; potential Cdc28p substrate [Source:SGD;Acc:S000006171]
P	YPL250W-A	YPL250W-A	4	-5.6	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified ORF RPL36B/YPL249C-A; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028589]
P	YPL251W	YPL251W	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; partially overlaps 5' end of the verified, essential gene YAH1/YPL252C [Source:SGD;Acc:S000006172]
P	YPL252C	YAH1	144	-30.3	4	Ferredoxin of the mitochondrial matrix required for formation of cellular iron-sulfur proteins; involved in heme A biosynthesis; homologous to human adrenodoxin [Source:SGD;Acc:S000006173]
P	YPL253C	VIK1	86	-69.1	4	Protein that forms a complex with Kar3p at the spindle pole body, possible regulator of Kar3p function in microtubule-mediated processes; required for sister chromatid cohesion; has similarity to Cik1p [Source:SGD;Acc:S000006174]
P	YPL254W	HFI1	518	-615.7	4	Adaptor protein required for structural integrity of the SAGA complex, a histone acetyltransferase-coactivator complex that is involved in global regulation of gene expression through acetylation and transcription functions [Source:SGD;Acc:S000006175]
P	YPL255W	BBP1	264	-132.9	4	Protein required for the spindle pole body (SPB) duplication, localized at the central plaque periphery; forms a complex with a nuclear envelope protein Mps2p and SPB components Spc29p and Kar1p; required for mitotic functions of Cdc5p [Source:SGD;Acc:S000006176]
P	YPL256C	CLN2	54	-891.6	4	G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p) [Source:SGD;Acc:S000006177]
P	YPL257W	YPL257W	6	-9.2	2	Putative protein of unknown function; homozygous diploid deletion strain exhibits low budding index; physically interacts with Hsp82p; YPL257W is not an essential gene [Source:SGD;Acc:S000006178]
P	YPL257W-A	YPL257W-A	4727	-1742.3	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007357]
P	YPL257W-B	YPL257W-B	5026	-2530.1	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007358]
P	YPL258C	THI21	399	-239.7	4	Hydroxymethylpyrimidine phosphate kinase, involved in the last steps in thiamine biosynthesis; member of a gene family with THI20 and THI22; Thi20p also has this activity [Source:SGD;Acc:S000006179]
P	YPL259C	APM1	516	-206	4	Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting [Source:SGD;Acc:S000006180]
P	YPL260W	YPL260W	1683	-760.5	4	Putative substrate of cAMP-dependent protein kinase (PKA); green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; YPL260W is not an essential gene [Source:SGD;Acc:S000006181]
P	YPL261C	YPL261C	5	-2.6	2	Dubious open reading frame unlikely to encode a protein; partially overlaps the uncharacterized ORF YPL260W [Source:SGD;Acc:S000006182]
P	YPL262W	FUM1	2205	-866.4	4	Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria [Source:SGD;Acc:S000006183]
P	YPL263C	KEL3	1153	-303.2	4	Cytoplasmic protein of unknown function [Source:SGD;Acc:S000006184]
P	YPL264C	YPL264C	14	-28.7	4	Putative membrane protein of unknown function; physically interacts with Hsp82p; YPL264C is not an essential gene [Source:SGD;Acc:S000006185]
P	YPL265W	DIP5	489	-120.9	4	Dicarboxylic amino acid permease, mediates high-affinity and high-capacity transport of L-glutamate and L-aspartate; also a transporter for Gln, Asn, Ser, Ala, and Gly [Source:SGD;Acc:S000006186]
P	YPL266W	DIM1	1227	-230.7	4	Essential 18S rRNA dimethylase (dimethyladenosine transferase), responsible for conserved m6(2)Am6(2)A dimethylation in 3'-terminal loop of 18S rRNA, part of 90S and 40S pre-particles in nucleolus, involved in pre-ribosomal RNA processing [Source:SGD;Acc:S000006187]
P	YPL267W	ACM1	143	-52.4	4	Pseudosubstrate inhibitor of the anaphase-promoting complex/cyclosome (APC/C), that suppresses APC/C [Cdh1]-mediated proteolysis of mitotic cyclins; associates with Cdh1p, Bmh1p and Bmh2p; cell cycle regulated protein [Source:SGD;Acc:S000006188]
P	YPL268W	PLC1	109	-40.6	4	Phospholipase C, hydrolyzes phosphatidylinositol 4,5-biphosphate (PIP2) to generate the signaling molecules inositol 1,4,5-triphosphate (IP3) and 1,2-diacylglycerol (DAG); involved in regulating many cellular processes [Source:SGD;Acc:S000006189]
P	YPL269W	KAR9	121	-66	4	Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase [Source:SGD;Acc:S000006190]
P	YPL270W	MDL2	611	-396.7	4	Mitochondrial inner membrane half-type ATP-binding cassette (ABC) transporter, required for respiratory growth at high temperature; similar to human TAP1 and TAP2 implicated in bare lymphocyte syndrome and Wegener-like granulomatosis [Source:SGD;Acc:S000006191]
P	YPL271W	ATP15	1194	-222.6	4	Epsilon subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis; phosphorylated [Source:SGD;Acc:S000006192]
P	YPL272C	PBI1	27	-14.6	3	Putative protein of unknown function; gene expression induced in response to ketoconazole; YPL272C is not an essential gene [Source:SGD;Acc:S000006193]
P	YPL273W	SAM4	1492	-475.8	4	S-adenosylmethionine-homocysteine methyltransferase, functions along with Mht1p in the conversion of S-adenosylmethionine (AdoMet) to methionine to control the methionine/AdoMet ratio [Source:SGD;Acc:S000006194]
P	YPL274W	SAM3	471	-256.3	4	High-affinity S-adenosylmethionine permease, required for utilization of S-adenosylmethionine as a sulfur source; has similarity to S-methylmethionine permease Mmp1p [Source:SGD;Acc:S000006195]
P	YPL277C	YPL277C	59	-117.9	4	Putative protein of unknown function; localized to the membranes; gene expression regulated by copper levels [Source:SGD;Acc:S000006198]
P	YPL278C	YPL278C	7	-14.1	2	Putative protein of unknown function; gene expression regulated by copper levels [Source:SGD;Acc:S000006199]
P	YPL279C	FEX2	52	-74.5	3	Putative protein of unknown function [Source:SGD;Acc:S000006200]
P	YPL280W	HSP32	128	-154.1	4	Possible chaperone and cysteine protease with similarity to E. coli Hsp31 and S. cerevisiae Hsp31p, Hsp33p, and Sno4p; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease [Source:SGD;Acc:S000006201]
P	YPL281C	ERR2	397	-415	4	Protein of unknown function, has similarity to enolases [Source:SGD;Acc:S000006202]
P	YPL282C	PAU22	17	-2.3	2	Protein of unknown function, member of the seripauperin multigene family encoded mainly in subtelomeric regions; identical to Pau21p; encodes 2 proteins that are translated from 2 different start codons [Source:SGD;Acc:S000006203]
P	YPL283C	YRF1-7	445	-454.8	4	Helicase encoded by the Y' element of subtelomeric regions, highly expressed in the mutants lacking the telomerase component TLC1; potentially phosphorylated by Cdc28p [Source:SGD;Acc:S000006204]
P	YPL283W-A	YPL283W-A	14	-25.7	2	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028723]
P	YPL283W-B	YPL283W-B	1	-1.8	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028724]
P	YPR001W	CIT3	315	-617.2	4	Dual specificity mitochondrial citrate and methylcitrate synthase; catalyzes the condensation of acetyl-CoA and oxaloacetate to form citrate and that of propionyl-CoA and oxaloacetate to form 2-methylcitrate [Source:SGD;Acc:S000006205]
P	YPR002C-A	YPR002C-A	1	-1.5	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the Ty1 long terminal repeat, YPRWdelta12 [Source:SGD;Acc:S000007254]
P	YPR002W	PDH1	495	-884.9	4	Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate [Source:SGD;Acc:S000006206]
P	YPR003C	YPR003C	80	-81.4	4	Putative sulfate permease; physically interacts with Hsp82p; green fluorescent protein (GFP)-fusion protein localizes to the ER; YPR003C is not an essential gene [Source:SGD;Acc:S000006207]
P	YPR004C	AIM45	1556	-340.4	4	Putative ortholog of mammalian electron transfer flavoprotein complex subunit ETF-alpha; interacts with frataxin, Yfh1p; null mutant displays elevated frequency of mitochondrial genome loss; may have a role in oxidative stress response [Source:SGD;Acc:S000006208]
P	YPR005C	HAL1	64	-51.3	4	Cytoplasmic protein involved in halotolerance; decreases intracellular Na+ (via Ena1p) and increases intracellular K+ by decreasing efflux; expression repressed by Ssn6p-Tup1p and Sko1p and induced by NaCl, KCl, and sorbitol through Gcn4p [Source:SGD;Acc:S000006209]
P	YPR006C	ICL2	278	-534.4	4	2-methylisocitrate lyase of the mitochondrial matrix, functions in the methylcitrate cycle to catalyze the conversion of 2-methylisocitrate to succinate and pyruvate; ICL2 transcription is repressed by glucose and induced by ethanol [Source:SGD;Acc:S000006210]
P	YPR007C	REC8	29	-20.5	2	Meiosis-specific component of sister chromatid cohesion complex; maintains cohesion between sister chromatids during meiosis I; maintains cohesion between centromeres of sister chromatids until meiosis II; homolog of S. pombe Rec8p [Source:SGD;Acc:S000006211]
P	YPR008W	HAA1	579	-378.9	4	Transcriptional activator involved in the transcription of TPO2, YRO2, and other genes putatively encoding membrane stress proteins; involved in adaptation to weak acid stress [Source:SGD;Acc:S000006212]
P	YPR009W	SUT2	39	-10.4	3	Putative transcription factor; multicopy suppressor of mutations that cause low activity of the cAMP/protein kinase A pathway; highly similar to Sut1p [Source:SGD;Acc:S000006213]
P	YPR010C	RPA135	2682	-1135.2	4	RNA polymerase I second largest subunit A135 [Source:SGD;Acc:S000006214]
P	YPR010C-A	YPR010C-A	756	-145	4	Putative protein of unknown function; conserved among Saccharomyces sensu stricto species [Source:SGD;Acc:S000122558]
P	YPR011C	YPR011C	163	-185.9	4	Putative transporter, member of the mitochondrial carrier family; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000006215]
P	YPR012W	YPR012W	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR012W is not an essential gene [Source:SGD;Acc:S000006216]
P	YPR013C	CMR3	18	-7.2	4	Putative zinc finger protein; YPR013C is not an essential gene [Source:SGD;Acc:S000006217]
P	YPR014C	YPR014C	2	-1.3	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; YPR014C is not an essential gene [Source:SGD;Acc:S000006218]
P	YPR015C	YPR015C	6	-6.8	4	Putative protein of unknown function; overexpression causes a cell cycle delay or arrest [Source:SGD;Acc:S000006219]
P	YPR016C	TIF6	1995	-202.8	4	Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits [Source:SGD;Acc:S000006220]
P	YPR016W-A	YPR016W-A	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007630]
P	YPR017C	DSS4	146	-90.8	4	Guanine nucleotide dissociation stimulator for Sec4p, functions in the post-Golgi secretory pathway; binds zinc, found both on membranes and in the cytosol [Source:SGD;Acc:S000006221]
P	YPR018W	RLF2	599	-233.1	4	Largest subunit (p90) of the Chromatin Assembly Complex (CAF-1); chromatin assembly by CAF-1 is important for multiple processes including silencing at telomeres, mating type loci, and rDNA; maintenance of kinetochore structure; deactivation of the   mage checkpoint after DNA repair; and chromatin dynamics during transcription [Source:SGD;Acc:S000006222]
P	YPR019W	MCM4	1341	-904.2	4	Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p [Source:SGD;Acc:S000006223]
P	YPR020W	ATP20	778	-214.7	4	Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex [Source:SGD;Acc:S000006224]
P	YPR021C	AGC1	207	-446.9	4	Mitochondrial amino acid transporter, acts both as a glutamate uniporter and as an aspartate-glutamate exchanger; involved in nitrogen metabolism and nitrogen compound biosynthesis [Source:SGD;Acc:S000006225]
P	YPR022C	YPR022C	290	-140.7	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000006226]
P	YPR023C	EAF3	622	-305.9	4	Esa1p-associated factor, nonessential component of the NuA4 acetyltransferase complex, homologous to Drosophila dosage compensation protein MSL3; plays a role in regulating Ty1 transposition [Source:SGD;Acc:S000006227]
P	YPR024W	YME1	1185	-707.2	4	Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; mutation causes an elevated rate of mitochondrial turnover [Source:SGD;Acc:S000006228]
P	YPR025C	CCL1	314	-1014.9	4	Cyclin associated with protein kinase Kin28p, which is the TFIIH-associated carboxy-terminal domain (CTD) kinase involved in transcription initiation at RNA polymerase II promoters [Source:SGD;Acc:S000006229]
P	YPR026W	ATH1	248	-267	4	Acid trehalase required for utilization of extracellular trehalose [Source:SGD;Acc:S000006230]
P	YPR027C	YPR027C	8	-2.4	2	Putative protein of unknown function [Source:SGD;Acc:S000006231]
P	YPR028W	YOP1	1477	-99.3	4	Membrane protein that interacts with Yip1p to mediate membrane traffic; interacts with Sey1p to maintain ER morphology; overexpression leads to cell death and accumulation of internal cell membranes [Source:SGD;Acc:S000006232]
P	YPR029C	APL4	924	-546.2	4	Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport [Source:SGD;Acc:S000006233]
P	YPR030W	CSR2	198	-445	4	Nuclear protein proposed to regulate utilization of nonfermentable carbon sources and endocytosis of plasma membrane proteins; overproduction suppresses chs5 spa2 lethality at high temp; ubiquitinated by Rsp5p, deubiquitinated by Ubp2p [Source:SGD;Acc:S000006234]
P	YPR031W	NTO1	126	-71.5	4	Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3 [Source:SGD;Acc:S000006235]
P	YPR032W	SRO7	702	-398.4	4	Effector of Rab GTPase Sec4p, forms a complex with Sec4p and t-SNARE Sec9p; involved in exocytosis and docking and fusion of post-Golgi vesicles with plasma membrane; homolog of Sro77p and Drosophila lgl tumor suppressor [Source:SGD;Acc:S000006236]
P	YPR033C	HTS1	2787	-882.8	4	Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome [Source:SGD;Acc:S000006237]
P	YPR034W	ARP7	660	-302	4	Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation [Source:SGD;Acc:S000006238]
P	YPR035W	GLN1	2905	-950	4	Glutamine synthetase (GS), synthesizes glutamine from glutamate and ammonia; with Glt1p, forms the secondary pathway for glutamate biosynthesis from ammonia; expression regulated by nitrogen source and by amino acid limitation [Source:SGD;Acc:S000006239]
P	YPR036W	VMA13	2598	-1016.6	4	Subunit H of the eight-subunit V1 peripheral membrane domain of the vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; serves as an activator or a structural stabilizer of the V-ATPase [Source:SGD;Acc:S000006240]
P	YPR036W-A	SPO24	110	-114.9	4	Protein of unknown function; transcription is regulated by Pdr1p [Source:SGD;Acc:S000028425]
P	YPR037C	ERV2	458	-121.6	4	Flavin-linked sulfhydryl oxidase localized to the endoplasmic reticulum lumen, involved in disulfide bond formation within the ER [Source:SGD;Acc:S000006241]
P	YPR038W	IRC16	3	-2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene YPR037C; null mutant displays increased levels of spontaneous Rad52p foci [Source:SGD;Acc:S000006242]
P	YPR039W	YPR039W	3	-14.2	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified non essential genes ERV2/YPR037C and TIP41/YPR040W [Source:SGD;Acc:S000006243]
P	YPR040W	TIP41	494	-200.7	4	Protein that interacts physically and genetically with Tap42p, which regulates protein phosphatase 2A; component of the TOR (target of rapamycin) signaling pathway [Source:SGD;Acc:S000006244]
P	YPR041W	TIF5	3031	-407.4	4	Translation initiation factor eIF5; functions both as a GTPase-activating protein to mediate hydrolysis of ribosome-bound GTP and as a GDP dissociation inhibitor to prevent recycling of eIF2 [Source:SGD;Acc:S000006245]
P	YPR042C	PUF2	400	-497.7	4	Member of the PUF protein family, which is defined by the presence of Pumilio homology domains that confer RNA binding activity; preferentially binds mRNAs encoding membrane-associated proteins [Source:SGD;Acc:S000006246]
P	YPR043W	RPL43A	3055	-346.7	4	Protein component of the large (60S) ribosomal subunit, identical to Rpl43Bp and has similarity to rat L37a ribosomal protein; null mutation confers a dominant lethal phenotype [Source:SGD;Acc:S000006247]
P	YPR044C	OPI11	2	-2.7	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene RPL43A/YPR043W; deletion confers sensitivity to GSAO [Source:SGD;Acc:S000006248]
P	YPR045C	THP3	226	-259.7	4	Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes [Source:SGD;Acc:S000006249]
P	YPR046W	MCM16	42	-27.6	4	Protein involved in kinetochore-microtubule mediated chromosome segregation; binds to centromere DNA [Source:SGD;Acc:S000006250]
P	YPR047W	MSF1	305	-330.3	4	Mitochondrial phenylalanyl-tRNA synthetase, active as a monomer, unlike the cytoplasmic subunit which is active as a dimer complexed to a beta subunit dimer; similar to the alpha subunit of E. coli phenylalanyl-tRNA synthetase [Source:SGD;Acc:S000006251]
P	YPR048W	TAH18	305	-275.5	4	Conserved NAPDH-dependent diflavin reductase, component of an early step in the cytosolic Fe-S protein assembly (CIA) machinery; transfers electrons from NADPH to the Fe-S cluster of Dre2p; plays a pro-death role under oxidative stress [Source:SGD;Acc:S000006252]
P	YPR049C	ATG11	244	-372.5	4	Adapter protein for pexophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; directs receptor-bound cargo to the phagophore assembly site (PAS) for packaging into vesicles; required for recruiting other proteins to the (PAS) [Source:SGD;Acc:S000006253]
P	YPR050C	YPR050C	1	-2.6	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MAK3/YPR051W [Source:SGD;Acc:S000006254]
P	YPR051W	MAK3	302	-122.9	4	Catalytic subunit of N-terminal acetyltransferase of the NatC type; required for replication of dsRNA virus [Source:SGD;Acc:S000006255]
P	YPR052C	NHP6A	1291	-119.2	4	High-mobility group (HMG) protein that binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Bp; homologous to mammalian HMGB1 and HMGB2 [Source:SGD;Acc:S000006256]
P	YPR053C	YPR053C	1	-3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C [Source:SGD;Acc:S000006257]
P	YPR054W	SMK1	365	-316.3	4	Middle sporulation-specific mitogen-activated protein kinase (MAPK) required for production of the outer spore wall layers; negatively regulates activity of the glucan synthase subunit Gsc2p [Source:SGD;Acc:S000006258]
P	YPR055W	SEC8	592	-508.5	4	Essential 121kDa subunit of the exocyst complex (Sec3p, Sec5p, Sec6p, Sec8p, Sec10p, Sec15p, Exo70p, and Exo84p), which has the essential function of mediating polarized targeting of secretory vesicles to active sites of exocytosis [Source:SGD;Acc:S000006259]
P	YPR056W	TFB4	133	-89.3	4	Subunit of TFIIH complex, involved in transcription initiation, similar to 34 kDa subunit of human TFIIH; interacts with Ssl1p [Source:SGD;Acc:S000006260]
P	YPR057W	BRR1	83	-120	4	snRNP protein component of spliceosomal snRNPs, required for pre-mRNA splicing and snRNP biogenesis; in null mutant newly-synthesized snRNAs are destabilized and 3'-end processing is slowed [Source:SGD;Acc:S000006261]
P	YPR058W	YMC1	578	-267.2	4	Mitochondrial protein, putative inner membrane transporter with a role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; has similarity with Ymc2p [Source:SGD;Acc:S000006262]
P	YPR059C	YPR059C	7	-2.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YMC1/YPR058W [Source:SGD;Acc:S000006263]
P	YPR060C	ARO7	1179	-251.2	4	Chorismate mutase, catalyzes the conversion of chorismate to prephenate to initiate the tyrosine/phenylalanine-specific branch of aromatic amino acid biosynthesis [Source:SGD;Acc:S000006264]
P	YPR061C	JID1	32	-50.1	3	Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae [Source:SGD;Acc:S000006265]
P	YPR062W	FCY1	1369	-176.5	4	Cytosine deaminase, zinc metalloenzyme that catalyzes the hydrolytic deamination of cytosine to uracil; of biomedical interest because it also catalyzes the deamination of 5-fluorocytosine (5FC) to form anticancer drug 5-fluorouracil (5FU) [Source:SGD;Acc:S000006266]
P	YPR063C	YPR063C	730	-145.8	4	ER-localized protein of unknown function [Source:SGD;Acc:S000006267]
P	YPR064W	YPR064W	2	-1.1	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006268]
P	YPR065W	ROX1	221	-95	4	Heme-dependent repressor of hypoxic genes; contains an HMG domain that is responsible for DNA bending activity [Source:SGD;Acc:S000006269]
P	YPR066W	UBA3	64	-57	4	Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000006270]
P	YPR067W	ISA2	232	-104.7	4	Protein required for maturation of mitochondrial [4Fe-4S] proteins; functions in a complex with Isa1p and possibly Iba57p; localizes to the mitochondrial intermembrane space, overexpression of ISA2 suppresses grx5 mutations [Source:SGD;Acc:S000006271]
P	YPR068C	HOS1	39	-156.4	4	Class I histone deacetylase (HDAC) family member that deacetylates Smc3p on lysine residues at anaphase onset; has sequence similarity to Hda1p, Rpd3p, Hos2p, and Hos3p; interacts with the Tup1p-Ssn6p corepressor complex [Source:SGD;Acc:S000006272]
P	YPR069C	SPE3	2421	-582.5	4	Spermidine synthase, involved in biosynthesis of spermidine and also in biosynthesis of pantothenic acid; spermidine is required for growth of wild-type cells [Source:SGD;Acc:S000006273]
P	YPR070W	MED1	397	-359.8	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation [Source:SGD;Acc:S000006274]
P	YPR071W	YPR071W	23	-23.5	4	Putative membrane protein; YPR071W is not an essential gene [Source:SGD;Acc:S000006275]
P	YPR072W	NOT5	1233	-526.8	4	Subunit of the CCR4-NOT complex, which is a global transcriptional regulator with roles in transcription initiation and elongation and in mRNA degradation [Source:SGD;Acc:S000006276]
P	YPR073C	LTP1	556	-99.6	4	Protein phosphotyrosine phosphatase of unknown cellular role; activated by adenine [Source:SGD;Acc:S000006277]
P	YPR074C	TKL1	3727	-1681.8	4	Transketolase, similar to Tkl2p; catalyzes conversion of xylulose-5-phosphate and ribose-5-phosphate to sedoheptulose-7-phosphate and glyceraldehyde-3-phosphate in the pentose phosphate pathway; needed for synthesis of aromatic amino acids [Source:SGD;Acc:S000006278]
P	YPR074W-A	YPR074W-A	2	-2.3	2	Hypothetical protein identified by homology [Source:SGD;Acc:S000007631]
P	YPR075C	OPY2	168	-136.2	4	Integral membrane protein that functions in the signaling branch of the high-osmolarity glycerol (HOG) pathway; interacts with Ste50p; overproduction blocks cell cycle arrest in the presence of mating pheromone [Source:SGD;Acc:S000006279]
P	YPR076W	YPR076W	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006280]
P	YPR077C	YPR077C	6	-12.1	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; expression increased by deletion of NAP1 [Source:SGD;Acc:S000006281]
P	YPR078C	YPR078C	13	-15.1	2	Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible [Source:SGD;Acc:S000006282]
P	YPR079W	MRL1	304	-113.6	4	Membrane protein with similarity to mammalian mannose-6-phosphate receptors, possibly functions as a sorting receptor in the delivery of vacuolar hydrolases [Source:SGD;Acc:S000006283]
P	YPR080W	TEF1	7994	-2657.5	4	Translational elongation factor EF-1 alpha; also encoded by TEF2; functions in the binding reaction of aminoacyl-tRNA (AA-tRNA) to ribosomes; may also have a role in tRNA re-export from the nucleus [Source:SGD;Acc:S000006284]
P	YPR081C	GRS2	381	-438.9	4	Protein with sequence similarity to Grs1p, which is a glycyl-tRNA synthetase; cannot substitute for Grs1p; possible pseudogene that is expressed at very low levels [Source:SGD;Acc:S000006285]
P	YPR082C	DIB1	164	-128.6	4	17-kDa component of the U4/U6aU5 tri-snRNP, plays an essential role in pre-mRNA splicing, orthologue of hDIM1, the human U5-specific 15-kDa protein [Source:SGD;Acc:S000006286]
P	YPR083W	MDM36	154	-170.9	4	Mitochondrial protein required for normal mitochondrial morphology and inheritance; proposed involvement in the formation of Dnm1p and Num1p-containing cortical anchor complexes that promote mitochondrial fission [Source:SGD;Acc:S000006287]
P	YPR084W	YPR084W	147	-95.7	4	Putative protein of unknown function [Source:SGD;Acc:S000006288]
P	YPR085C	ASA1	56	-71.4	4	Putative protein of unknown function; subunit of the ASTRA complex (Rvb1p, Rvb2p, Tra1p, Tti1p, Tti2, Asa1p and Tra1p) which is part of the chromatin remodeling machinery [Source:SGD;Acc:S000006289]
P	YPR086W	SUA7	939	-186.2	4	Transcription factor TFIIB, a general transcription factor required for transcription initiation and start site selection by RNA polymerase II [Source:SGD;Acc:S000006290]
P	YPR087W	VPS69	0	nf	1	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 85% of ORF overlaps the verified gene SRP54; deletion causes a vacuolar protein sorting defect [Source:SGD;Acc:S000006291]
P	YPR088C	SRP54	1724	-346.6	4	Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain [Source:SGD;Acc:S000006292]
P	YPR089W	YPR089W	572	-307.6	4	Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p [Source:SGD;Acc:S000006293]
P	YPR091C	NVJ2	1426	-523	4	Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; GFP-fusion protein localizes to the ER; contains a PH domain and binds phosphatidylinositols and other lipids in a large-scale study [Source:SGD;Acc:S000006295]
P	YPR092W	YPR092W	3	-1.6	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006296]
P	YPR093C	ASR1	25	-65.4	4	Ubiquitin ligase that modifies and regulates RNA Pol II; involved in a putative alcohol-responsive signaling pathway; accumulates in the nucleus under alcohol stress; contains a Ring/PHD finger domain similar to the mammalian rA9 protein [Source:SGD;Acc:S000006297]
P	YPR094W	RDS3	155	-56.3	4	Component of the SF3b subcomplex of the U2 snRNP, zinc cluster protein involved in pre-mRNA splicing and cycloheximide resistance [Source:SGD;Acc:S000006298]
P	YPR095C	SYT1	217	-205.9	4	Guanine nucleotide exchange factor (GEF) for Arf proteins; promotes activation of Arl1p, which recruits Imh1p to the Golgi; involved in vesicular transport; member of the Sec7-domain family; contains a PH domain [Source:SGD;Acc:S000006299]
P	YPR096C	YPR096C	2	-1.6	1	Protein of unknown function that may interact with ribosomes, based on co-purification experiments [Source:SGD;Acc:S000006300]
P	YPR097W	YPR097W	635	-547.8	4	Protein that contains a Phox homology (PX) domain and binds phosphoinositides; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies [Source:SGD;Acc:S000006301]
P	YPR098C	YPR098C	130	-69.8	4	Protein of unknown function, localized to the mitochondrial outer membrane [Source:SGD;Acc:S000006302]
P	YPR099C	YPR099C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene MRPL51/YPR100W [Source:SGD;Acc:S000006303]
P	YPR100W	MRPL51	302	-87.8	4	Mitochondrial ribosomal protein of the large subunit [Source:SGD;Acc:S000006304]
P	YPR101W	SNT309	78	-188.6	4	Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; interacts physically and genetically with Prp19p [Source:SGD;Acc:S000006305]
P	YPR102C	RPL11A	4482	-409.9	4	Protein of the large 60S ribosomal subunit, nearly identical to Rpl11Bp but expressed at twice the level; involved in ribosomal assembly; depletion causes degradation of 60S proteins and RNA; similar to E. coli L5 and rat L11 [Source:SGD;Acc:S000006306]
P	YPR103W	PRE2	1336	-321.6	4	Beta 5 subunit of the 20S proteasome, responsible for the chymotryptic activity of the proteasome [Source:SGD;Acc:S000006307]
P	YPR104C	FHL1	616	-387.7	4	Regulator of ribosomal protein transcription; has forkhead associated domain that binds phosphorylated proteins; also has forkhead DNA-binding domain but does not bind DNA in vitro; suppresses RNA pol III and splicing factor prp4 mutants [Source:SGD;Acc:S000006308]
P	YPR105C	COG4	454	-356.9	4	Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments [Source:SGD;Acc:S000006309]
P	YPR106W	ISR1	75	-1696.3	4	Predicted protein kinase, overexpression causes sensitivity to staurosporine, which is a potent inhibitor of protein kinase C [Source:SGD;Acc:S000006310]
P	YPR107C	YTH1	92	-77.5	4	Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation [Source:SGD;Acc:S000006311]
P	YPR108W	RPN7	1804	-466.4	4	Essential, non-ATPase regulatory subunit of the 26S proteasome, similar to another S. cerevisiae regulatory subunit, Rpn5p, as well as to mammalian proteasome subunits [Source:SGD;Acc:S000006312]
P	YPR108W-A	YPR108W-A	7	-2	2	Putative protein of unknown function; identified by fungal homology and RT-PCR [Source:SGD;Acc:S000028590]
P	YPR109W	YPR109W	59	-79.9	4	Predicted membrane protein; dipoid deletion strain has high budding index [Source:SGD;Acc:S000006313]
P	YPR110C	RPC40	2385	-300.8	4	RNA polymerase subunit AC40, common to RNA polymerase I and III [Source:SGD;Acc:S000006314]
P	YPR111W	DBF20	280	-1241.1	4	Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis [Source:SGD;Acc:S000006315]
P	YPR112C	MRD1	1548	-439.9	4	Essential conserved protein that is part of the 90S preribosome; required for production of 18S rRNA and small ribosomal subunit; contains five consensus RNA-binding domains [Source:SGD;Acc:S000006316]
P	YPR113W	PIS1	812	-154.7	4	Phosphatidylinositol synthase, required for biosynthesis of phosphatidylinositol, which is a precursor for polyphosphoinositides, sphingolipids, and glycolipid anchors for some of the plasma membrane proteins [Source:SGD;Acc:S000006317]
P	YPR114W	YPR114W	396	-53.3	4	Putative protein of unknown function [Source:SGD;Acc:S000006318]
P	YPR115W	RGC1	900	-2192.8	4	Pleckstrin homology domain containing protein proposed to function as a glycerol channel activator; paralogous to Ask10p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm [Source:SGD;Acc:S000006319]
P	YPR116W	RRG8	47	-47.1	4	Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport [Source:SGD;Acc:S000006320]
P	YPR117W	YPR117W	129	-149.3	4	Putative protein of unknown function [Source:SGD;Acc:S000006321]
P	YPR118W	MRI1	1449	-329.5	4	5'-methylthioribose-1-phosphate isomerase; catalyzes the isomerization of 5-methylthioribose-1-phosphate to 5-methylthioribulose-1-phosphate in the methionine salvage pathway [Source:SGD;Acc:S000006322]
P	YPR119W	CLB2	162	-1129.6	4	B-type cyclin involved in cell cycle progression; activates Cdc28p to promote the transition from G2 to M phase; accumulates during G2 and M, then targeted via a destruction box motif for ubiquitin-mediated degradation by the proteasome [Source:SGD;Acc:S000006323]
P	YPR120C	CLB5	58	-685.4	4	B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase [Source:SGD;Acc:S000006324]
P	YPR121W	THI22	135	-28.7	2	Protein with similarity to hydroxymethylpyrimidine phosphate kinases; member of a gene family with THI20 and THI21; not required for thiamine biosynthesis [Source:SGD;Acc:S000006325]
P	YPR122W	AXL1	166	-164.5	4	Haploid specific endoprotease that performs one of two N-terminal cleavages during maturation of a-factor mating pheromone; required for axial budding pattern of haploid cells [Source:SGD;Acc:S000006326]
P	YPR123C	YPR123C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially/completely overlaps the verified ORF CTR [Source:SGD;Acc:S000006327]
P	YPR124W	CTR1	894	-187.1	4	High-affinity copper transporter of the plasma membrane, mediates nearly all copper uptake under low copper conditions; transcriptionally induced at low copper levels and degraded at high copper levels [Source:SGD;Acc:S000006328]
P	YPR125W	YLH47	576	-320.1	4	Mitochondrial inner membrane protein exposed to the mitochondrial matrix, associates with mitochondrial ribosomes, NOT required for respiratory growth; homolog of human Letm1, a protein implicated in Wolf-Hirschhorn syndrome [Source:SGD;Acc:S000006329]
P	YPR126C	YPR126C	11	-1.9	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006330]
P	YPR127W	YPR127W	861	-387.7	4	Protein of unknown function, differentially expressed during alcoholic fermentation; expression activated by transcription factor YRM1/YOR172W; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus [Source:SGD;Acc:S000006331]
P	YPR128C	ANT1	459	-151.3	4	Peroxisomal adenine nucleotide transporter; involved in beta-oxidation of medium-chain fatty acid; required for peroxisome proliferation [Source:SGD;Acc:S000006332]
P	YPR129W	SCD6	1265	-347.6	4	Protein containing an Lsm domain; negatively regulates translation initiation via 48S preinitiation complex assembly; may bind RNA and have a role in RNA processing; overproduction suppresses null mutation in clathrin heavy chain gene CHC1 [Source:SGD;Acc:S000006333]
P	YPR130C	YPR130C	2	-1.2	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006334]
P	YPR131C	NAT3	329	-146.2	4	Catalytic subunit of the NatB N-terminal acetyltransferase, which catalyzes acetylation of the amino-terminal methionine residues of all proteins beginning with Met-Asp or Met-Glu and of some proteins beginning with Met-Asn or Met-Met [Source:SGD;Acc:S000006335]
P	YPR132W	RPS23B	3313	-300	4	Ribosomal protein 28 (rp28) of the small (40S) ribosomal subunit, required for translational accuracy; nearly identical to Rps23Ap and similar to E. coli S12 and rat S23 ribosomal proteins; deletion of both RPS23A and RPS23B is lethal [Source:SGD;Acc:S000006336]
P	YPR133C	SPN1	2113	-457.4	4	Protein involved in RNA polymerase II transcription; interacts genetically or physically with RNAP II, TBP, TFIIS, and chromatin remodelling factors; central domain highly conserved throughout eukaryotes; mutations confer an Spt- phenotype [Source:SGD;Acc:S000006337]
P	YPR133W-A	TOM5	653	-81.5	4	Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore [Source:SGD;Acc:S000006433]
P	YPR134W	MSS18	81	-148.1	4	Nuclear encoded protein needed for efficient splicing of mitochondrial COX1 aI5beta intron; mss18 mutations block cleavage of 5' exon - intron junction; phenotype of intronless strain suggests additional functions [Source:SGD;Acc:S000006338]
P	YPR135W	CTF4	966	-965.3	4	Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion [Source:SGD;Acc:S000006339]
P	YPR136C	YPR136C	3	-3.2	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9 [Source:SGD;Acc:S000006340]
P	YPR137C-A	YPR137C-A	4693	-1783.9	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007359]
P	YPR137C-B	YPR137C-B	5022	-2475.7	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007360]
P	YPR137W	RRP9	977	-270.4	4	Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein [Source:SGD;Acc:S000006341]
P	YPR138C	MEP3	54	-17.3	3	Ammonium permease of high capacity and low affinity; belongs to a ubiquitous family of cytoplasmic membrane proteins that transport only ammonium (NH4+); expression is under the nitrogen catabolite repression regulation ammonia permease [Source:SGD;Acc:S000006342]
P	YPR139C	LOA1	571	-211.9	4	lysophosphatidic acid acyltransferase; involved in triacelglyceride homeostasis and lipid droplet formation; localized to lipid droplets and the ER; specificity for oleoyl-CoA [Source:SGD;Acc:S000006343]
P	YPR140W	TAZ1	137	-160.8	4	Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome [Source:SGD;Acc:S000006344]
P	YPR141C	KAR3	227	-195.6	4	Minus-end-directed microtubule motor that functions in mitosis and meiosis, localizes to the spindle pole body and localization is dependent on functional Cik1p, required for nuclear fusion during mating; potential Cdc28p substrate [Source:SGD;Acc:S000006345]
P	YPR142C	YPR142C	7	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RRP15, which is required for ribosomal RNA processing [Source:SGD;Acc:S000006346]
P	YPR143W	RRP15	839	-100.7	4	Nucleolar protein, constituent of pre-60S ribosomal particles; required for proper processing of the 27S pre-rRNA at the A3 and B1 sites to yield mature 5.8S and 25S rRNAs [Source:SGD;Acc:S000006347]
P	YPR144C	NOC4	540	-253.1	4	Nucleolar protein, forms a complex with Nop14p that mediates maturation and nuclear export of 40S ribosomal subunits [Source:SGD;Acc:S000006348]
P	YPR145C-A	YPR145C-A	1	-2.2	2	Putative protein of unknown function [Source:SGD;Acc:S000113589]
P	YPR145W	ASN1	3323	-1046.6	4	Asparagine synthetase, isozyme of Asn2p; catalyzes the synthesis of L-asparagine from L-aspartate in the asparagine biosynthetic pathway [Source:SGD;Acc:S000006349]
P	YPR146C	YPR146C	2	-1.4	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006350]
P	YPR147C	YPR147C	123	-77.4	4	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS [Source:SGD;Acc:S000006351]
P	YPR148C	YPR148C	1572	-386.5	4	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern [Source:SGD;Acc:S000006352]
P	YPR149W	NCE102	1189	-185.6	4	Protein of unknown function; contains transmembrane domains; involved in secretion of proteins that lack classical secretory signal sequences; component of the detergent-insoluble glycolipid-enriched complexes (DIGs) [Source:SGD;Acc:S000006353]
P	YPR150W	YPR150W	3	-1.7	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene SUE1/YPR151C [Source:SGD;Acc:S000006354]
P	YPR151C	SUE1	7	-43.5	2	Mitochondrial protein required for degradation of unstable forms of cytochrome c [Source:SGD;Acc:S000006355]
P	YPR152C	URN1	157	-157.9	4	Putative protein of unknown function containing WW and FF domains; overexpression causes accumulation of cells in G1 phase [Source:SGD;Acc:S000006356]
P	YPR153W	YPR153W	4	-28.6	4	Putative protein of unknown function [Source:SGD;Acc:S000006357]
P	YPR154W	PIN3	920	-125.1	4	Protein that induces appearance of [PIN+] prion when overproduced [Source:SGD;Acc:S000006358]
P	YPR155C	NCA2	289	-350.1	4	Protein involved in regulation of mitochondrial expression of subunits 6 (Atp6p) and 8 (Atp8p) of the Fo-F1 ATP synthase; functions with Nca3p [Source:SGD;Acc:S000006359]
P	YPR156C	TPO3	921	-195.5	4	Polyamine transport protein specific for spermine; localizes to the plasma membrane; member of the major facilitator superfamily [Source:SGD;Acc:S000006360]
P	YPR157W	TDA6	11	-5.6	2	Putative protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; null mutant is sensitive to expression of the top1-T722A allele [Source:SGD;Acc:S000006361]
P	YPR158C-C	YPR158C-C	4687	-1617.6	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007361]
P	YPR158C-D	YPR158C-D	5041	-2257	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007362]
P	YPR158W	CUR1	8	-22.8	2	Protein of unknown function involved in destabilization of [URE3] prions; similar in sequence to Btn2p [Source:SGD;Acc:S000006362]
P	YPR158W-A	YPR158W-A	4516	-1620.1	4	Retrotransposon TYA Gag gene co-transcribed with TYB Pol; translated as TYA or TYA-TYB polyprotein; Gag is a nucleocapsid protein that is the structural constituent of virus-like particles (VLPs); similar to retroviral Gag [Source:SGD;Acc:S000007363]
P	YPR158W-B	YPR158W-B	4891	-2356.2	4	Retrotransposon TYA Gag and TYB Pol genes; transcribed/translated as one unit; polyprotein is processed to make a nucleocapsid-like protein (Gag), reverse transcriptase (RT), protease (PR), and integrase (IN); similar to retroviral genes [Source:SGD;Acc:S000007364]
P	YPR159C-A	YPR159C-A	1	-3.1	2	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028725]
P	YPR159W	KRE6	1409	-265.6	4	Type II integral membrane protein required for beta-1,6 glucan biosynthesis; putative beta-glucan synthase; localizes to the ER, plasma membrane, sites of polarized growth and secretory vesicles; functionally redundant with Skn1p [Source:SGD;Acc:S000006363]
P	YPR160C-A	YPR160C-A	4	-1.6	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028726]
P	YPR160W	GPH1	2055	-1805.8	4	Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway [Source:SGD;Acc:S000006364]
P	YPR160W-A	YPR160W-A	2	-2.3	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028860]
P	YPR161C	SGV1	861	-671	4	Cyclin (Bur2p)-dependent protein kinase that functions in transcriptional regulation; phosphorylates the carboxy-terminal domain of Rpo21p and the C-terminal repeat domain of Spt5p; regulated by Cak1p; similar to metazoan CDK9 proteins [Source:SGD;Acc:S000006365]
P	YPR162C	ORC4	302	-284.9	4	Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing [Source:SGD;Acc:S000006366]
P	YPR163C	TIF3	2514	-571.8	4	Translation initiation factor eIF-4B, has RNA annealing activity; contains an RNA recognition motif and binds to single-stranded RNA [Source:SGD;Acc:S000006367]
P	YPR164W	MMS1	341	-277.3	4	Subunit of an E3 ubiquitin ligase complex involved in resolving replication intermediates or preventing the damage caused by blocked replication forks; regulates Ty1 transposition; involved with Rtt101p in nonfunctional rRNA decay [Source:SGD;Acc:S000006368]
P	YPR165W	RHO1	2161	-421	4	GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p) [Source:SGD;Acc:S000006369]
P	YPR166C	MRP2	110	-65.8	4	Mitochondrial ribosomal protein of the small subunit [Source:SGD;Acc:S000006370]
P	YPR167C	MET16	184	-184.8	4	3'-phosphoadenylsulfate reductase, reduces 3'-phosphoadenylyl sulfate to adenosine-3',5'-bisphosphate and free sulfite using reduced thioredoxin as cosubstrate, involved in sulfate assimilation and methionine metabolism [Source:SGD;Acc:S000006371]
P	YPR168W	NUT2	187	-59.2	4	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; required for transcriptional activation and has a role in basal transcription [Source:SGD;Acc:S000006372]
P	YPR169W	JIP5	713	-168.1	4	Essential protein required for biogenesis of the large ribosomal subunit; interacts with proteins involved in RNA processing, ribosome biogenesis, ubiquitination and demethylation; similar to WDR55, a human WD repeat protein [Source:SGD;Acc:S000006373]
P	YPR169W-A	YPR169W-A	16	-7.4	3	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps two other dubious ORFs: YPR170C and YPR170W-B [Source:SGD;Acc:S000028591]
P	YPR170C	YPR170C	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORFs YPR169W-A and YPR170W-B [Source:SGD;Acc:S000006374]
P	YPR170W-A	YPR170W-A	0	nf	1	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; identified by expression profiling and mass spectrometry [Source:SGD;Acc:S000028861]
P	YPR170W-B	YPR170W-B	24	-25.2	4	Putative protein of unknown function, conserved in fungi; partially overlaps the dubious genes YPR169W-A, YPR170W-A and YRP170C [Source:SGD;Acc:S000028515]
P	YPR171W	BSP1	511	-354.4	4	Adapter that links synaptojanins Inp52p and Inp53p to the cortical actin cytoskeleton [Source:SGD;Acc:S000006375]
P	YPR172W	YPR172W	850	-140.8	4	Protein of unknown function, transcriptionally activated by Yrm1p along with genes involved in multidrug resistance [Source:SGD;Acc:S000006376]
P	YPR173C	VPS4	966	-374.7	4	AAA-ATPase involved in multivesicular body (MVB) protein sorting, ATP-bound Vps4p localizes to endosomes and catalyzes ESCRT-III disassembly and membrane release; ATPase activity is activated by Vta1p; regulates cellular sterol metabolism [Source:SGD;Acc:S000006377]
P	YPR174C	YPR174C	342	-130	4	Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nuclear periphery; potential Cdc28p substrate; binds phosphatidylinositols and phosphatidylethanolamine in a large-scale study [Source:SGD;Acc:S000006378]
P	YPR175W	DPB2	297	-226.3	4	Second largest subunit of DNA polymerase II (DNA polymerase epsilon), required for normal yeast chromosomal replication; expression peaks at the G1/S phase boundary; potential Cdc28p substrate [Source:SGD;Acc:S000006379]
P	YPR176C	BET2	193	-116	4	Beta subunit of Type II geranylgeranyltransferase required for vesicular transport between the endoplasmic reticulum and the Golgi; provides a membrane attachment moiety to Rab-like proteins Ypt1p and Sec4p [Source:SGD;Acc:S000006380]
P	YPR177C	YPR177C	17	-2.1	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the 5' end of the essential PRP4 gene encoding a component of the U4/U6-U5 snRNP complex [Source:SGD;Acc:S000006381]
P	YPR178W	PRP4	296	-97.7	4	Splicing factor, component of the U4/U6-U5 snRNP complex [Source:SGD;Acc:S000006382]
P	YPR179C	HDA3	377	-462.2	4	Subunit of a possibly tetrameric trichostatin A-sensitive class II histone deacetylase complex that contains an Hda1p homodimer and an Hda2p-Hda3p heterodimer; required for the activity of the complex; has similarity to Hda2p [Source:SGD;Acc:S000006383]
P	YPR180W	AOS1	578	-166.6	4	Subunit of a heterodimeric nuclear SUMO activating enzyme (E1) with Uba2p; activates Smt3p (SUMO) before its conjugation to proteins (sumoylation), which may play a role in protein targeting; essential for viability [Source:SGD;Acc:S000006384]
P	YPR181C	SEC23	2855	-1145.2	4	GTPase-activating protein, stimulates the GTPase activity of Sar1p; component of the Sec23p-Sec24p heterodimer of the COPII vesicle coat, involved in ER to Golgi transport; substrate of Ubp3/Bre5 complex; ubiquitylated by Ub-ligase Rsp5p; proteasome  ted degradation of Sec23p is regulated by Cdc48p [Source:SGD;Acc:S000006385]
P	YPR182W	SMX3	322	-51.5	4	Core Sm protein Sm F; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Sme1p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm F [Source:SGD;Acc:S000006386]
P	YPR183W	DPM1	2519	-528.6	4	Dolichol phosphate mannose (Dol-P-Man) synthase of the ER membrane, catalyzes the formation of Dol-P-Man from Dol-P and GDP-Man; required for glycosyl phosphatidylinositol membrane anchoring, O mannosylation, and protein glycosylation [Source:SGD;Acc:S000006387]
P	YPR184W	GDB1	896	-1142.1	4	Glycogen debranching enzyme containing glucanotranferase and alpha-1,6-amyloglucosidase activities, required for glycogen degradation; phosphorylated in mitochondria; activity is inhibited by Igd1p [Source:SGD;Acc:S000006388]
P	YPR185W	ATG13	560	-285.9	4	Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling [Source:SGD;Acc:S000006389]
P	YPR186C	PZF1	94	-253	4	Transcription factor IIIA (TFIIIA); essential DNA binding protein required for transcription of 5S rRNA by RNA polymerase III; not involved in transcription of other RNAP III genes; nine conserved zinc fingers; may also bind 5S rRNA [Source:SGD;Acc:S000006390]
P	YPR187W	RPO26	940	-133.8	4	RNA polymerase subunit ABC23, common to RNA polymerases I, II, and III; part of central core; similar to bacterial omega subunit [Source:SGD;Acc:S000006391]
P	YPR188C	MLC2	404	-121.1	4	Regulatory light chain for the type II myosin, Myo1p; binds to an IQ motif of Myo1p, localization to the bud neck depends on Myo1p; involved in the disassembly of the Myo1p ring [Source:SGD;Acc:S000006392]
P	YPR189W	SKI3	1064	-790.5	4	Ski complex component and TPR protein, mediates 3'-5' RNA degradation by the cytoplasmic exosome; null mutants have superkiller phenotype of increased viral dsRNAs and are synthetic lethal with mutations in 5'-3' mRNA decay [Source:SGD;Acc:S000006393]
P	YPR190C	RPC82	966	-389.6	4	RNA polymerase III subunit C82 [Source:SGD;Acc:S000006394]
P	YPR191W	QCR2	2643	-935.3	4	Subunit 2 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; phosphorylated; transcription is regulated by Hap1p, Hap2p/Hap3p, and heme [Source:SGD;Acc:S000006395]
P	YPR192W	AQY1	29	-16.6	2	Spore-specific water channel that mediates the transport of water across cell membranes, developmentally controlled; may play a role in spore maturation, probably by allowing water outflow, may be involved in freeze tolerance [Source:SGD;Acc:S000006396]
P	YPR193C	HPA2	25	-35.1	4	Tetrameric histone acetyltransferase with similarity to Gcn5p, Hat1p, Elp3p, and Hpa3p; acetylates histones H3 and H4 in vitro and exhibits autoacetylation activity [Source:SGD;Acc:S000006397]
P	YPR194C	OPT2	21	-21.2	2	Oligopeptide transporter; member of the OPT family, with potential orthologs in S. pombe and C. albicans; also plays a role in formation of mature vacuoles [Source:SGD;Acc:S000006398]
P	YPR195C	YPR195C	6	-2.3	2	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006399]
P	YPR196W	YPR196W	15	-48.3	2	Putative maltose activator [Source:SGD;Acc:S000006400]
P	YPR197C	YPR197C	18	-2.9	2	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000006401]
P	YPR198W	SGE1	28	-25.2	4	Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations [Source:SGD;Acc:S000006402]
P	YPR199C	ARR1	8	-20.2	2	Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds [Source:SGD;Acc:S000006403]
P	YPR200C	ARR2	8	-69.8	4	Arsenate reductase required for arsenate resistance; converts arsenate to arsenite which can then be exported from cells by Arr3p [Source:SGD;Acc:S000006404]
P	YPR201W	ARR3	39	-21	4	Plasma membrane metalloid/H+ antiporter; transports arsenite and antimonite; required for resistance to arsenic compounds; transcription is activated by Arr1p in the presence of arsenite [Source:SGD;Acc:S000006405]
P	YPR202W	YPR202W	118	-71.4	4	Putative protein of unknown function with similarity to telomere-encoded helicases; YPR202W is not an essential gene; transcript is predicted to be spliced but there is no evidence that it is spliced in vivo [Source:SGD;Acc:S000006406]
P	YPR203W	YPR203W	51	-21.4	4	Putative protein of unknown function [Source:SGD;Acc:S000006407]
P	YPR204C-A	YPR204C-A	1	-1.8	1	Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching [Source:SGD;Acc:S000028727]
P	YPR204W	YPR204W	307	-244.1	4	Helicase-like protein encoded within the telomeric Y' element [Source:SGD;Acc:S000006408]
Q	Q0010	Q0010	0	nf	1	Dubious mitochondrial open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF Q0017 [Source:SGD;Acc:S000007257]
Q	Q0017	Q0017	0	nf	1	Dubious mitochondrial open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the dubious ORF Q0010 [Source:SGD;Acc:S000007258]
Q	Q0032	Q0032	3	-1.1	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007259]
Q	Q0045	COX1	408	-225.3	4	Subunit I of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits [Source:SGD;Acc:S000007260]
Q	Q0050	AI1	69	-149.8	4	Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene [Source:SGD;Acc:S000007261]
Q	Q0055	AI2	44	-115.2	3	Reverse transcriptase required for splicing of the COX1 pre-mRNA, encoded by a mobile group II intron within the mitochondrial COX1 gene [Source:SGD;Acc:S000007262]
Q	Q0060	AI3	19	-57.8	2	Endonuclease I-SceIII, encoded by a mobile group I intron within the mitochondrial COX1 gene [Source:SGD;Acc:S000007263]
Q	Q0065	AI4	34	-76	4	Endonuclease I-SceII, encoded by a mobile group I intron within the mitochondrial COX1 gene; intron is normally spliced by the BI4p maturase but AI4p can mutate to acquire the same maturase activity [Source:SGD;Acc:S000007264]
Q	Q0070	AI5_ALPHA	22	-61.1	3	Endonuclease I-SceIV, involved in intron mobility; encoded by a mobile group I intron within the mitochondrial COX1 gene [Source:SGD;Acc:S000007265]
Q	Q0075	AI5_BETA	11	-3.6	2	Protein of unknown function, encoded within an intron of the mitochondrial COX1 gene; translational initiation codon is predicted to be ATA rather than ATG [Source:SGD;Acc:S000007266]
Q	Q0080	ATP8	0	nf	1	Subunit 8 of the F0 sector of mitochondrial inner membrane F1-F0 ATP synthase, encoded on the mitochondrial genome; ATP8 and ATP6 mRNAs are not translated in the absence of the F1 sector of ATPase [Source:SGD;Acc:S000007267]
Q	Q0085	ATP6	233	-110.5	4	Mitochondrially encoded subunit a of the F0 sector of mitochondrial F1F0 ATP synthase; translation is specifically activated by Atp22p; ATP6 and ATP8 mRNAs are not translated in the absence of the F1 sector of ATPase [Source:SGD;Acc:S000007268]
Q	Q0092	Q0092	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007269]
Q	Q0105	COB	89	-54.1	3	Cytochrome b, mitochondrially encoded subunit of the ubiquinol-cytochrome c reductase complex which includes Cobp, Rip1p, Cyt1p, Cor1p, Qcr2p, Qcr6p, Qcr7p, Qcr8p, Qcr9p, and Qcr10p [Source:SGD;Acc:S000007270]
Q	Q0110	BI2	89	-68.6	3	Mitochondrial mRNA maturase with a role in splicing, encoded by both exon and intron sequences of partially processed COB mRNA [Source:SGD;Acc:S000007271]
Q	Q0115	BI3	82	-36.6	3	Mitochondrial mRNA maturase, forms a complex with Mrs1p to mediate splicing of the bI3 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA [Source:SGD;Acc:S000007272]
Q	Q0120	BI4	92	-83.2	3	Mitochondrial mRNA maturase, forms a complex with Nam2p to mediate splicing of the bI4 intron of the COB gene; encoded by both exon and intron sequences of partially processed COB mRNA [Source:SGD;Acc:S000007273]
Q	Q0130	OLI1	18	-30	4	F0-ATP synthase subunit c (ATPase-associated proteolipid), encoded on the mitochondrial genome; mutation confers oligomycin resistance; expression is specifically dependent on the nuclear genes AEP1 and AEP2 [Source:SGD;Acc:S000007274]
Q	Q0140	VAR1	603	-356.3	4	Mitochondrial ribosomal protein of the small subunit, mitochondrially-encoded; polymorphic in different strains due to variation in number of AAT (asparagine) codons; translated near the mitochondrial inner membrane [Source:SGD;Acc:S000007275]
Q	Q0142	Q0142	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps dubious open reading frame Q0143 [Source:SGD;Acc:S000007276]
Q	Q0143	Q0143	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007277]
Q	Q0144	Q0144	0	nf	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007278]
Q	Q0160	SCEI	8	-31.1	4	I-SceI DNA endonuclease, encoded by the mitochondrial group I intron of the 21S_rRNA gene; mediates gene conversion that propagates the intron into intron-less copies of the 21S_rRNA gene [Source:SGD;Acc:S000007279]
Q	Q0182	Q0182	1	-1.7	1	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data [Source:SGD;Acc:S000007280]
Q	Q0250	COX2	690	-326	4	Subunit II of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits [Source:SGD;Acc:S000007281]
Q	Q0255	Q0255	10	-99.2	2	Maturase-like protein [Source:SGD;Acc:S000007282]
Q	Q0275	COX3	18	-31.6	4	Subunit III of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain; one of three mitochondrially-encoded subunits [Source:SGD;Acc:S000007283]
Q	Q0297	Q0297	5	-2.5	2	Dubious open reading frame of the mitochondrial genome; unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene RPM1 [Source:SGD;Acc:S000007284]