Volumes and Surface Areas
|
Residue
Volume |
Surface
Area |
Side Chain
pKa |
| A | 88.6 | 115 | - |
| R | 173.4 | 225 | ~12 |
| D | 111.1 | 150 | 4.5 |
| N | 114.1 | 160 | - |
| C | 108.5 | 135 | 9.1-9.5 |
| E | 138.4 | 190 | 4.6 |
| Q | 143.8 | 180 | - |
| G | 60.1 | 75 | - |
| H | 153.2 | 195 | 6.2 |
| I | 166.7 | 175 | - |
| L | 166.7 | 170 | - |
| K | 168.6 | 200 | 10.4 |
| M | 162.9 | 185 | - |
| F | 189.9 | 210 | - |
| P | 112.7 | 145 | - |
| S | 89.0 | 115 | - |
| T | 116.1 | 140 | - |
| W | 227.8 | 255 | - |
| Y | 193.6 | 230 | 9.7 |
| V | 140.0 | 155 | - |
a-amino pKa = 6.8 - 7.9, a-carboxyl pKa = 3.5 - 4.3
References
Volume:
A.A. Zamyatin, Protein Volume in Solution, Prog. Biophys. Mol. Biol.
24(1972)107-123.
Accessible surface area:
(calculated for the residue X in the tripeptide G-X-G)
C. Chotia, The Nature of the Accessible and Buried Surfaces in
Proteins, J. Mol. Biol., 105(1975)1-14.
pKa:
C. Tandford, Adv. Protein Chem. 17(1962)69-165.